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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3811319
log Bayes Factor = 19.9487
Chromosome 14   position 22,482,497  (GRCh37) Explore rs3811319 on Ensembl!
Variant rs3811319 is part of Cluster X0246

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
I30-I52 Other forms of heart disease
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter XIV Diseases of the genitourinary system
0.999 0.001 0.000
Chapter VI Diseases of the nervous system
0.999 0.001 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.997 0.003 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.997 0.003 0.000
M20-M25 Other joint disorders
0.993 0.007 0.000
N17-N19 Renal failure
0.989 0.011 0.000
I50 Heart failure
0.985 0.015 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.984 0.016 0.000
G90-G99 Other disorders of the nervous system
0.977 0.023 0.000
G40-G47 Episodic and paroxysmal disorders
0.976 0.024 0.000
M20 Acquired deformities of fingers and toes
0.975 0.025 0.000
G40 Epilepsy
0.970 0.030 0.000
N17 Acute renal failure
0.967 0.033 0.000
M45-M49 Spondylopathies
0.962 0.038 0.000
I51 Complications and ill-defined descriptions of heart disease
0.961 0.039 0.000
Chapter XXI Factors influencing health status and contact with health services
0.960 0.040 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.958 0.042 0.000
M20.5 Other deformities of toe(s) (acquired)
0.957 0.043 0.000
G40.9 Epilepsy, unspecified
0.957 0.043 0.000
N40-N51 Diseases of male genital organs
0.954 0.046 0.000
S60-S69 Injuries to the wrist and hand
0.952 0.048 0.000
N17.9 Acute renal failure, unspecified
0.951 0.049 0.000
G93 Other disorders of brain
0.948 0.052 0.000
E65-E68 Obesity and other hyperalimentation
0.940 0.060 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.939 0.061 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.939 0.061 0.000
Z92 Personal history of medical treatment
0.938 0.062 0.000
I34 Nonrheumatic mitral valve disorders
0.937 0.063 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.937 0.063 0.000
N25-N29 Other disorders of kidney and ureter
0.927 0.073 0.000
Z95 Presence of cardiac and vascular implants and grafts
0.926 0.074 0.000
E70-E90 Metabolic disorders
0.924 0.076 0.000
I50.0 Congestive heart failure
0.923 0.077 0.000
Z93 Artificial opening status
0.914 0.086 0.000
Z92.1 Personal history of long-term (current) use of anticoagulants
0.914 0.086 0.000
R50-R69 General symptoms and signs
0.911 0.089 0.000
E66 Obesity
0.909 0.091 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.904 0.096 0.000
I05-I09 Chronic rheumatic heart diseases
0.902 0.098 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.902 0.098 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.902 0.098 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.898 0.102 0.000
I51.8 Other ill-defined heart diseases
0.897 0.103 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.894 0.106 0.000
E66.9 Obesity, unspecified
0.891 0.109 0.000
R10-R19 Symptoms and signs involving the digestive system and abdomen
0.891 0.109 0.000
G35 Multiple sclerosis
0.891 0.109 0.000
M23 Internal derangement of knee
0.888 0.112 0.000
Chapter V Mental and behavioural disorders
0.888 0.112 0.000
I42 Cardiomyopathy
0.886 0.114 0.000
E78.0 Pure hypercholesterolaemia
0.886 0.114 0.000
M20.2 Hallux rigidus
0.885 0.115 0.000
I46 Cardiac arrest
0.884 0.116 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.880 0.120 0.000
N10-N16 Renal tubulo-interstitial diseases
0.879 0.121 0.000
I50.9 Heart failure, unspecified
0.877 0.123 0.000
N28 Other disorders of kidney and ureter, not elsewhere classified
0.875 0.125 0.000
Z92.6 Personal history of chemotherapy for neoplastic disease
0.873 0.127 0.000
I34.0 Mitral (valve) insufficiency
0.872 0.128 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.872 0.128 0.000
M48 Other spondylopathies
0.870 0.130 0.000
I71 Aortic aneurysm and dissection
0.870 0.130 0.000
M15-M19 Arthrosis
0.869 0.131 0.000
N19 Unspecified renal failure
0.869 0.131 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.869 0.131 0.000
I50.1 Left ventricular failure
0.866 0.134 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.856 0.144 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.854 0.146 0.000
Chapter VIII Diseases of the ear and mastoid process
0.851 0.149 0.000
M65-M68 Disorders of synovium and tendon
0.850 0.150 0.000
I51.7 Cardiomegaly
0.848 0.152 0.000
I31 Other diseases of pericardium
0.846 0.154 0.000
M40-M43 Deforming dorsopathies
0.844 0.156 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.841 0.159 0.000
M47 Spondylosis
0.840 0.160 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.838 0.162 0.000
I44 Atrioventricular and left bundle-branch block
0.837 0.163 0.000
Z95.1 Presence of aortocoronary bypass graft
0.837 0.163 0.000
Z87 Personal history of other diseases and conditions
0.835 0.165 0.000
N70-N77 Inflammatory diseases of female pelvic organs
0.832 0.168 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.831 0.169 0.000
Z85 Personal history of malignant neoplasm
0.831 0.169 0.000
Chapter XX External causes of morbidity and mortality
0.830 0.170 0.000
G93.3 Postviral fatigue syndrome
0.830 0.170 0.000
I49 Other cardiac arrhythmias
0.829 0.171 0.000
N41 Inflammatory diseases of prostate
0.826 0.174 0.000
S90-S99 Injuries to the ankle and foot
0.826 0.174 0.000
M25 Other joint disorders, not elsewhere classified
0.825 0.175 0.000
N47 Redundant prepuce, phimosis and paraphimosis
0.825 0.175 0.000
G95 Other diseases of spinal cord
0.822 0.178 0.000
G93.6 Cerebral oedema
0.819 0.181 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.819 0.181 0.000
Chapter XXII Codes for special purposes
0.817 0.183 0.000
R47-R49 Symptoms and signs involving speech and voice
0.816 0.184 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.816 0.184 0.000
M50-M54 Other dorsopathies
0.816 0.184 0.000
I95 Hypotension
0.815 0.185 0.000
I10-I15 Hypertensive diseases
0.815 0.185 0.000
Chapter I Certain infectious and parasitic diseases
0.815 0.185 0.000
Z93.6 Other artificial openings of urinary tract status
0.815 0.185 0.000
S64 Injury of nerves at wrist and hand level
0.814 0.186 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.812 0.188 0.000
Z88 Personal history of allergy to drugs, medicaments and biologocal substances
0.812 0.188 0.000
M70-M79 Other soft tissue disorders
0.812 0.188 0.000
S20-S29 Injuries to the thorax
0.811 0.189 0.000
Z95.2 Presence of prosthetic heart valve
0.811 0.189 0.000
N28.1 Cyst of kidney, acquired
0.810 0.190 0.000
R87 Abnormal findings in specimens from female genital organs
0.810 0.190 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.807 0.193 0.000
M48.0 Spinal stenosis
0.805 0.195 0.000
G93.0 Cerebral cysts
0.804 0.196 0.000
I08 Multiple valve diseases
0.802 0.198 0.000
N50 Other disorders of male genital organs
0.801 0.199 0.000
Z94 Transplanted organ and tissue status
0.796 0.204 0.000
I47 Paroxysmal tachycardia
0.792 0.208 0.000
G40.2 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
0.790 0.210 0.000
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness
0.786 0.214 0.000
T66-T78 Other and unspecified effects of external causes
0.786 0.214 0.000
Chapter II Neoplasms
0.785 0.215 0.000
M46 Other inflammatory spondylopathies
0.782 0.218 0.000
T79-T79 Certain early complications of trauma
0.781 0.219 0.000
N41.9 Inflammatory disease of prostate, unspecified
0.779 0.221 0.000
M20.0 Deformity of finger(s)
0.779 0.221 0.000
N18 Chronic renal failure
0.778 0.222 0.000
I46.0 Cardiac arrest with successful resuscitation
0.777 0.223 0.000
I45 Other conduction disorders
0.776 0.224 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.775 0.225 0.000
G81 Hemiplegia
0.775 0.225 0.000
R51 Headache
0.774 0.226 0.000
I77 Other disorders of arteries and arterioles
0.772 0.228 0.000
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.770 0.230 0.000
G40.1 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
0.770 0.230 0.000
S61 Open wound of wrist and hand
0.768 0.232 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.766 0.234 0.000
R41.0 Disorientation, unspecified
0.765 0.235 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.765 0.235 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.764 0.235 0.000
M16 Coxarthrosis [arthrosis of hip]
0.764 0.236 0.000
G40.6 Grand mal seizures, unspecified (with or without petit mal)
0.764 0.236 0.000
Z87.2 Personal history of diseases of the skin and subcutaneous tissue
0.762 0.238 0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.761 0.239 0.000
S60 Superficial injury of wrist and hand
0.761 0.239 0.000
I71.0 Dissection of aorta [any part]
0.759 0.241 0.000
I33 Acute and subacute endocarditis
0.758 0.242 0.000
N42 Other disorders of prostate
0.757 0.243 0.000
R52 Pain, not elsewhere classified
0.756 0.244 0.000
I34.1 Mitral (valve) prolapse
0.756 0.244 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.755 0.245 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.755 0.245 0.000
G93.8 Other specified disorders of brain
0.754 0.246 0.000
Z88.1 Personal history of allergy to other antibiotic agents
0.753 0.247 0.000
I60-I69 Cerebrovascular diseases
0.753 0.247 0.000
S69 Other and unspecified injuries of wrist and hand
0.752 0.248 0.000
N00-N08 Glomerular diseases
0.752 0.248 0.000
M86-M90 Other osteopathies
0.751 0.249 0.000
I08.1 Disorders of both mitral and tricuspid valves
0.750 0.249 0.000
Chapter XI Diseases of the digestive system
0.750 0.250 0.000
I44.7 Left bundle-branch block, unspecified
0.750 0.250 0.000
M65 Synovitis and tenosynovitis
0.749 0.251 0.000
N13 Obstructive and reflux uropathy
0.748 0.252 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.748 0.252 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.747 0.253 0.000
R87.6 Abnormal cytological findings
0.746 0.254 0.000
I42.0 Dilated cardiomyopathy
0.746 0.254 0.000
R54 Senility
0.744 0.256 0.000
L40-L45 Papulosquamous disorders
0.743 0.257 0.000
M24 Other specific joint derangements
0.743 0.257 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.742 0.257 0.000
L50-L54 Urticaria and erythema
0.740 0.260 0.000
Z92.3 Personal history of irradiation
0.740 0.260 0.000
Z89 Acquired absence of limb
0.739 0.260 0.000
M23.3 Other meniscus derangements
0.739 0.261 0.000
R15 Faecal incontinence
0.738 0.262 0.000
E86 Volume depletion
0.737 0.263 0.000
M22 Disorders of patella
0.736 0.264 0.000
Z93.2 Ileostomy status
0.736 0.264 0.000
S00-S09 Injuries to the head
0.735 0.265 0.000
R18 Ascites
0.734 0.266 0.000
I31.3 Pericardial effusion (noninflammatory)
0.733 0.267 0.000
R10 Abdominal and pelvic pain
0.732 0.268 0.000
E20-E35 Disorders of other endocrine glands
0.732 0.268 0.000
E00-E07 Disorders of thyroid gland
0.731 0.269 0.000
N99-N99 Other disorders of the genitourinary system
0.731 0.269 0.000
L97 Ulcer of lower limb, not elsewhere classified
0.730 0.270 0.000
Z85.6 Personal history of leukaemia
0.730 0.270 0.000
I38 Endocarditis, valve unspecified
0.729 0.271 0.000
M43 Other deforming dorsopathies
0.729 0.271 0.000
E50-E64 Other nutritional deficiencies
0.728 0.272 0.000
Z99 Dependence on enabling machines and devices, not elsewhere classified
0.728 0.272 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.728 0.272 0.000
I27 Other pulmonary heart diseases
0.728 0.272 0.000
Q60-Q64 Congenital malformations of the urinary system
0.727 0.273 0.000
Z97 Presence of other devices
0.727 0.273 0.000
N40 Hyperplasia of prostate
0.726 0.274 0.000
R79 Other abnormal findings of blood chemistry
0.726 0.274 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.725 0.275 0.000
I05 Rheumatic mitral valve diseases
0.725 0.275 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.725 0.275 0.000
Z95.8 Presence of other cardiac and vascular implants and grafts
0.724 0.276 0.000
G70-G73 Diseases of myoneural junction and muscle
0.724 0.276 0.000
M21 Other acquired deformities of limbs
0.723 0.277 0.000
A30-A49 Other bacterial diseases
0.722 0.278 0.000
M47.8 Other spondylosis
0.721 0.279 0.000
I42.9 Cardiomyopathy, unspecified
0.719 0.281 0.000
N28.9 Disorder of kidney and ureter, unspecified
0.719 0.281 0.000
R47 Speech disturbances, not elsewhere classified
0.718 0.282 0.000
R14 Flatulence and related conditions
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I52 Other heart disorders in diseases classified elsewhere
0.717 0.283 0.000
I48 Atrial fibrillation and flutter
0.717 0.283 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.717 0.283 0.000
I41 Myocarditis in diseases classified elsewhere
0.717 0.283 0.000
I40 Acute myocarditis
0.717 0.283 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.717 0.283 0.000
I37 Pulmonary valve disorders
0.717 0.283 0.000
I36 Nonrheumatic tricuspid valve disorders
0.717 0.283 0.000
I32 Pericarditis in diseases classified elsewhere
0.717 0.283 0.000
I30 Acute pericarditis
0.717 0.283 0.000
Chapter X Diseases of the respiratory system
0.717 0.283 0.000
M91-M94 Chondropathies
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.717 0.283 0.000
N12 Tubulo-interstitial nephritis, not specified as acute or chronic
0.717 0.283 0.000
R68 Other general symptoms and signs
0.717 0.283 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.716 0.283 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.716 0.283 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.716 0.284 0.000
Z95.4 Presence of other heart-valve replacement
0.716 0.284 0.000
M48.09 Spinal stenosis (Site unspecified)
0.716 0.284 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.716 0.284 0.000
S64.4 Injury of digital nerve of other finger
0.715 0.285 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.715 0.285 0.000
T33-T35 Frostbite
0.715 0.285 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.715 0.285 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.715 0.285 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.715 0.285 0.000
T00-T07 Injuries involving multiple body regions
0.715 0.285 0.000
S10-S19 Injuries to the neck
0.715 0.285 0.000
R50 Fever of unknown origin
0.713 0.287 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.713 0.287 0.000
G91 Hydrocephalus
0.713 0.287 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.712 0.288 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.712 0.288 0.000
M34 Systemic sclerosis
0.712 0.288 0.000
M33 Dermatopolymyositis
0.712 0.288 0.000
M32 Systemic lupus erythematosus
0.712 0.288 0.000
M30 Polyarteritis nodosa and related conditions
0.712 0.288 0.000
Z93.4 Other artificial openings of gastro-intestinal tract status
0.712 0.288 0.000
E78.2 Mixed hyperlipidaemia
0.712 0.288 0.000
G30-G32 Other degenerative diseases of the nervous system
0.711 0.288 0.000
R82 Other abnormal findings in urine
0.711 0.289 0.000
G95.2 Cord compression, unspecified
0.711 0.289 0.000
Z93.0 Tracheostomy status
0.708 0.291 0.000
Z93.5 Cystostomy status
0.708 0.292 0.000
N50.8 Other specified disorders of male genital organs
0.708 0.292 0.000
R61 Hyperhidrosis
0.707 0.293 0.000
I95.2 Hypotension due to drugs
0.706 0.294 0.000
E40-E46 Malnutrition
0.705 0.294 0.000
G81.9 Hemiplegia, unspecified
0.705 0.295 0.000
I26 Pulmonary embolism
0.705 0.295 0.000
E88 Other metabolic disorders
0.704 0.296 0.000
R10.1 Pain localised to upper abdomen
0.704 0.296 0.000
G93.9 Disorder of brain, unspecified
0.704 0.296 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.703 0.297 0.000
Z88.5 Personal history of allergy to narcotic agent
0.702 0.298 0.000
N60-N64 Disorders of breast
0.702 0.298 0.000
Z95.5 Presence of coronary angioplasty implant and graft
0.702 0.298 0.000
M31 Other necrotising vasculopathies
0.702 0.298 0.000
M50 Cervical disk disorders
0.700 0.300 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.700 0.300 0.000
G96 Other disorders of central nervous system
0.700 0.300 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.700 0.300 0.000
G90 Disorders of autonomic nervous system
0.700 0.300 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.700 0.300 0.000
G92 Toxic encephalopathy
0.700 0.300 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.700 0.300 0.000
G41 Status epilepticus
0.700 0.300 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.699 0.301 0.000
M20.3 Other deformity of hallux (acquired)
0.699 0.301 0.000
G45 Transient cerebral ischaemic attacks and related syndromes
0.699 0.301 0.000
G40.3 Generalised idiopathic epilepsy and epileptic syndromes
0.699 0.301 0.000
C91 Lymphoid leukaemia
0.698 0.302 0.000
I95.1 Orthostatic hypotension
0.698 0.302 0.000
I70 Atherosclerosis
0.698 0.302 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.697 0.303 0.000
M16.1 Other primary coxarthrosis
0.697 0.303 0.000
G40.8 Other epilepsy
0.695 0.304 0.000
G40.7 Petit mal, unspecified, without grand mal seizures
0.695 0.304 0.000
G40.5 Special epileptic syndromes
0.695 0.304 0.000
G40.4 Other generalised epilepsy and epileptic syndromes
0.695 0.304 0.000
G40.0 Localisation-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localised onset
0.695 0.304 0.000
I72 Other aneurysm
0.695 0.305 0.000
I98 Other disorders of circulatory system in diseases classified elsewhere
0.695 0.305 0.000
F30-F39 Mood [affective] disorders
0.695 0.305 0.000
S62 Fracture at wrist and hand level
0.695 0.305 0.000
M05-M14 Inflammatory polyarthropathies
0.694 0.306 0.000
N17.8 Other acute renal failure
0.693 0.307 0.000
N17.2 Acute renal failure with medullary necrosis
0.693 0.307 0.000
N17.1 Acute renal failure with acute cortical necrosis
0.693 0.307 0.000
N17.0 Acute renal failure with tubular necrosis
0.693 0.307 0.000
R85 Abnormal findings in specimens from digestive organs and abdominal cavity
0.693 0.307 0.000
I49.4 Other and unspecified premature depolarisation
0.693 0.307 0.000
R55 Syncope and collapse
0.693 0.307 0.000
M25.4 Effusion of joint
0.692 0.307 0.000
M48.07 Spinal stenosis (Lumbosacral region)
0.692 0.308 0.000
Z85.7 Personal history of other malignant neoplasms of lymphoid, haematopoietic and related tissues
0.691 0.309 0.000
M18 Arthrosis of first carpometacarpal joint
0.690 0.310 0.000
M49 Spondylopathies in diseases classified elsewhere
0.690 0.310 0.000
I46.9 Cardiac arrest, unspecified
0.689 0.311 0.000
I51.6 Cardiovascular disease, unspecified
0.689 0.311 0.000
I51.5 Myocardial degeneration
0.689 0.311 0.000
I51.4 Myocarditis, unspecified
0.689 0.311 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.689 0.311 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.689 0.311 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.689 0.311 0.000
I51.0 Cardiac septal defect, acquired
0.689 0.311 0.000
M45 Ankylosing spondylitis
0.689 0.311 0.000
R56 Convulsions, not elsewhere classified
0.688 0.311 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.688 0.312 0.000
Z84 Family history of other conditions
0.687 0.313 0.000
Z81 Family history of mental and behavioural disorders
0.687 0.313 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.686 0.314 0.000
S70-S79 Injuries to the hip and thigh
0.686 0.314 0.000
Z95.3 Presence of xenogenic heart valve
0.685 0.315 0.000
N48 Other disorders of penis
0.685 0.315 0.000
Z87.4 Personal history of diseases of the genito-urinary system
0.685 0.315 0.000
N51 Disorders of male genital organs in diseases classified elsewhere
0.684 0.316 0.000
N49 Inflammatory disorders of male genital organs, not elsewhere classified
0.684 0.316 0.000
N46 Male infertility
0.684 0.316 0.000
N44 Torsion of testis
0.684 0.316 0.000
Q50-Q56 Congenital malformations of genital organs
0.684 0.316 0.000
L20-L30 Dermatitis and eczema
0.684 0.316 0.000
S66.2 Injury of extensor muscle and tendon of thumb at wrist and hand level
0.683 0.317 0.000
S67 Crushing injury of wrist and hand
0.683 0.317 0.000
S65 Injury of blood vessels at wrist and hand level
0.683 0.317 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.683 0.317 0.000
G37 Other demyelinating diseases of central nervous system
0.682 0.318 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.681 0.319 0.000
K70-K77 Diseases of liver
0.681 0.319 0.000
I51.9 Heart disease, unspecified
0.681 0.319 0.000
H60-H62 Diseases of external ear
0.680 0.320 0.000
G93.7 Reye's syndrome
0.680 0.320 0.000
G93.5 Compression of brain
0.680 0.320 0.000
G93.4 Encephalopathy, unspecified
0.680 0.320 0.000
G93.2 Benign intracranial hypertension
0.680 0.320 0.000
G93.1 Anoxic brain damage, not elsewhere classified
0.680 0.320 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.680 0.320 0.000
G20-G26 Extrapyramidal and movement disorders
0.679 0.320 0.000
I78 Diseases of capillaries
0.678 0.322 0.000
N72 Inflammatory disease of cervix uteri
0.678 0.322 0.000
R63 Symptoms and signs concerning food and fluid intake
0.677 0.323 0.000
T93 Sequelae of injuries of lower limb
0.677 0.323 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.676 0.324 0.000
S61.0 Open wound of finger(s) without damage to nail
0.676 0.324 0.000
Z98 Other postsurgical states
0.676 0.324 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.676 0.324 0.000
F60-F69 Disorders of adult personality and behaviour
0.675 0.325 0.000
C92 Myeloid leukaemia
0.675 0.325 0.000
Z00-Z13 Persons encountering health services for examination and investigation
0.674 0.326 0.000
E67 Other hyperalimentation
0.674 0.326 0.000
E68 Sequelae of hyperalimentation
0.674 0.326 0.000
E65 Localised adiposity
0.674 0.326 0.000
Z93.3 Colostomy status
0.674 0.326 0.000
Z88.2 Personal history of allergy to sulphonamides
0.674 0.326 0.000
M47.82 Other spondylosis (Cervical region)
0.674 0.326 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.673 0.326 0.000
L10-L14 Bullous disorders
0.673 0.326 0.000
I10 Essential (primary) hypertension
0.673 0.327 0.000
Z92.9 Personal history of medical treatment, unspecified
0.673 0.327 0.000
Z92.8 Personal history of other medical treatment
0.673 0.327 0.000
Z92.5 Personal history of rehabilitation measures
0.673 0.327 0.000
Z92.0 Personal history of contraception
0.673 0.327 0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.672 0.328 0.000
I34.8 Other nonrheumatic mitral valve disorders
0.672 0.328 0.000
I34.2 Nonrheumatic mitral (valve) stenosis
0.672 0.328 0.000
R17 Unspecified jaundice
0.672 0.328 0.000
G36 Other acute disseminated demyelination
0.672 0.328 0.000
Z91 Personal history of risk-factors, not elsewhere classified
0.672 0.328 0.000
R94 Abnormal results of function studies
0.672 0.328 0.000
M23.20 Derangement of meniscus due to old tear or injury (Multiple sites)
0.669 0.331 0.000
M23.4 Loose body in knee
0.669 0.331 0.000
H80-H83 Diseases of inner ear
0.669 0.331 0.000
M77 Other enthesopathies
0.669 0.331 0.000
I49.9 Cardiac arrhythmia, unspecified
0.668 0.332 0.000
E78.9 Disorder of lipoprotein metabolism, unspecified
0.668 0.332 0.000
L91 Hypertrophic disorders of skin
0.668 0.332 0.000
I42.2 Other hypertrophic cardiomyopathy
0.667 0.333 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.667 0.333 0.000
M47.9 Spondylosis, unspecified
0.666 0.334 0.000
N29 Other disorders of kidney and ureter in diseases classified elsewhere
0.664 0.335 0.000
N27 Small kidney of unknown cause
0.664 0.335 0.000
N25 Disorders resulting from impaired renal tubular function
0.664 0.335 0.000
N26 Unspecified contracted kidney
0.664 0.335 0.000
M80-M85 Disorders of bone density and structure
0.663 0.336 0.000
R45 Symptoms and signs involving emotional state
0.663 0.337 0.000
T59 Toxic effect of other gases, fumes and vapours
0.663 0.337 0.000
Z94.8 Other transplanted organ and tissue status
0.663 0.337 0.000
C91.1 Chronic lymphocytic leukaemia
0.663 0.337 0.000
N76 Other inflammation of vagina and vulva
0.663 0.337 0.000
N20-N23 Urolithiasis
0.663 0.337 0.000
E85 Amyloidosis
0.663 0.337 0.000
E84 Cystic fibrosis
0.663 0.337 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.663 0.337 0.000
E79 Disorders of purine and pyrimidine metabolism
0.663 0.337 0.000
E77 Disorders of glycoprotein metabolism
0.663 0.337 0.000
E76 Disorders of glycosaminoglycan metabolism
0.663 0.337 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.663 0.337 0.000
E74 Other disorders of carbohydrate metabolism
0.663 0.337 0.000
E73 Lactose intolerance
0.663 0.337 0.000
E72 Other disorders of amino-acid metabolism
0.663 0.337 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.663 0.337 0.000
E70 Disorders of aromatic amino-acid metabolism
0.663 0.337 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.663 0.337 0.000
I47.9 Paroxysmal tachycardia, unspecified
0.662 0.338 0.000
R59 Enlarged lymph nodes
0.662 0.338 0.000
S80-S89 Injuries to the knee and lower leg
0.662 0.338 0.000
I69 Sequelae of cerebrovascular disease
0.662 0.338 0.000
R90 Abnormal findings on diagnostic imaging of central nervous system
0.661 0.338 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.661 0.339 0.000
S32 Fracture of lumbar spine and pelvis
0.660 0.340 0.000
H90-H95 Other disorders of ear
0.660 0.340 0.000
M19 Other arthrosis
0.658 0.342 0.000
R74 Abnormal serum enzyme levels
0.657 0.343 0.000
M65.9 Synovitis and tenosynovitis, unspecified
0.657 0.343 0.000
Z88.3 Personal history of allergy to other anti-infective agents
0.656 0.344 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.655 0.345 0.000
Z93.9 Artificial opening status, unspecified
0.655 0.345 0.000
Z93.8 Other artificial opening status
0.655 0.345 0.000
N75 Diseases of Bartholin's gland
0.655 0.345 0.000
M48.02 Spinal stenosis (Cervical region)
0.655 0.345 0.000
K90-K93 Other diseases of the digestive system
0.654 0.345 0.000
M46.9 Inflammatory spondylopathy, unspecified
0.654 0.346 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.653 0.347 0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]
0.653 0.347 0.000
R62 Lack of expected normal physiological development
0.653 0.347 0.000
R57 Shock, not elsewhere classified
0.653 0.347 0.000
R64 Cachexia
0.653 0.347 0.000
R58 Haemorrhage, not elsewhere classified
0.653 0.347 0.000
S90 Superficial injury of ankle and foot
0.653 0.347 0.000
Z93.1 Gastrostomy status
0.653 0.347 0.000
I74 Arterial embolism and thrombosis
0.653 0.347 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.652 0.348 0.000
C15-C26 Malignant neoplasms of digestive organs
0.652 0.348 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.652 0.348 0.000
E66.1 Drug-induced obesity
0.652 0.348 0.000
E66.0 Obesity due to excess calories
0.652 0.348 0.000
M54 Dorsalgia
0.652 0.348 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.650 0.349 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.649 0.351 0.000
N28.8 Other specified disorders of kidney and ureter
0.649 0.351 0.000
R46 Symptoms and signs involving appearance and behaviour
0.648 0.352 0.000
R43 Disturbances of smell and taste
0.648 0.352 0.000
L98 Other disorders of skin and subcutaneous tissue, not elsewhere classified
0.648 0.352 0.000
T92 Sequelae of injuries of upper limb
0.648 0.352 0.000
A41 Other septicaemia
0.648 0.352 0.000
R79.8 Other specified abnormal findings of blood chemistry
0.648 0.352 0.000
G43 Migraine
0.647 0.353 0.000
M25.5 Pain in joint
0.647 0.353 0.000
I09 Other rheumatic heart diseases
0.647 0.353 0.000
I07 Rheumatic tricuspid valve diseases
0.647 0.353 0.000
I06 Rheumatic aortic valve diseases
0.647 0.353 0.000
M43.1 Spondylolisthesis
0.647 0.353 0.000
N18.9 Chronic renal failure, unspecified
0.647 0.353 0.000
S91 Open wound of ankle and foot
0.647 0.353 0.000
E78.8 Other disorders of lipoprotein metabolism
0.647 0.353 0.000
E78.6 Lipoprotein deficiency
0.647 0.353 0.000
E78.4 Other hyperlipidaemia
0.647 0.353 0.000
E78.3 Hyperchylomicronaemia
0.647 0.353 0.000
E78.1 Pure hyperglyceridaemia
0.647 0.353 0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.647 0.353 0.000
I99 Other and unspecified disorders of circulatory system
0.647 0.353 0.000
N30-N39 Other diseases of urinary system
0.645 0.355 0.000
T75 Effects of other external causes
0.645 0.355 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.645 0.355 0.000
R89 Abnormal findings in specimens from other organs, systems and tissues
0.644 0.356 0.000
R86 Abnormal findings in specimens from male genital organs
0.644 0.356 0.000
R84 Abnormal findings in specimens from respiratory organs and thorax
0.644 0.356 0.000
R83 Abnormal findings in cerebrospinal fluid
0.644 0.356 0.000
R47.8 Other and unspecified speech disturbances
0.643 0.357 0.000
R16 Hepatomegaly and splenomegaly, not elsewhere classified
0.643 0.357 0.000
M50.2 Other cervical disk displacement
0.643 0.357 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.642 0.358 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.641 0.359 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.641 0.359 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.641 0.359 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.641 0.359 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.641 0.359 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.641 0.359 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.641 0.359 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.641 0.359 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.641 0.359 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.641 0.359 0.000
T36 Poisoning by systemic antibiotics
0.641 0.359 0.000
G44 Other headache syndromes
0.640 0.359 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

This website was created, designed, and edited by ORCID iD iconPatrick K. Albers

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