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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3831366
log Bayes Factor = 12.5792
Chromosome 1   position 1,334,052  (GRCh37) Explore rs3831366 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
J30-J39 Other diseases of upper respiratory tract
1.000 0.000 0.000
Chapter X Diseases of the respiratory system
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.999 0.001 0.000
J34 Other disorders of nose and nasal sinuses
0.999 0.001 0.000
Chapter XX External causes of morbidity and mortality
0.998 0.002 0.000
Chapter VIII Diseases of the ear and mastoid process
0.998 0.002 0.000
M50-M54 Other dorsopathies
0.998 0.002 0.000
J34.2 Deviated nasal septum
0.997 0.003 0.000
M54 Dorsalgia
0.997 0.003 0.000
M20-M25 Other joint disorders
0.995 0.005 0.000
K51 Ulcerative colitis
0.993 0.007 0.000
Chapter XI Diseases of the digestive system
0.993 0.007 0.000
M54.5 Low back pain
0.993 0.007 0.000
M45-M49 Spondylopathies
0.992 0.008 0.000
K50-K52 Noninfective enteritis and colitis
0.992 0.008 0.000
K51.9 Ulcerative colitis, unspecified
0.992 0.008 0.000
H65-H75 Diseases of middle ear and mastoid
0.988 0.012 0.000
M80-M85 Disorders of bone density and structure
0.985 0.015 0.000
M54.59 Low back pain (Site unspecified)
0.978 0.022 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.978 0.022 0.000
M47 Spondylosis
0.978 0.022 0.000
M24 Other specific joint derangements
0.975 0.025 0.000
J40-J47 Chronic lower respiratory diseases
0.974 0.026 0.000
J33 Nasal polyp
0.974 0.026 0.000
J44 Other chronic obstructive pulmonary disease
0.973 0.027 0.000
J44.9 Chronic obstructive pulmonary disease, unspecified
0.968 0.032 0.000
M23 Internal derangement of knee
0.967 0.033 0.000
M81 Osteoporosis without pathological fracture
0.964 0.036 0.000
S80-S89 Injuries to the knee and lower leg
0.963 0.037 0.000
J33.0 Polyp of nasal cavity
0.960 0.040 0.000
M47.9 Spondylosis, unspecified
0.953 0.047 0.000
M40-M43 Deforming dorsopathies
0.953 0.047 0.000
M24.1 Other articular cartilage disorders
0.948 0.052 0.000
M81.9 Osteoporosis, unspecified
0.945 0.055 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.945 0.055 0.000
K40-K46 Hernia
0.944 0.056 0.000
H74 Other disorders of middle ear and mastoid
0.944 0.056 0.000
K51.3 Ulcerative (chronic) rectosigmoiditis
0.941 0.059 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.936 0.064 0.000
K43 Ventral hernia
0.933 0.067 0.000
K43.9 Ventral hernia without obstruction or gangrene
0.926 0.074 0.000
Chapter VI Diseases of the nervous system
0.926 0.074 0.000
M24.16 Other articular cartilage disorders (Lower leg)
0.922 0.078 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.920 0.080 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.917 0.083 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.914 0.086 0.000
J34.3 Hypertrophy of nasal turbinates
0.911 0.089 0.000
J44.8 Other specified chronic obstructive pulmonary disease
0.910 0.090 0.000
H60-H62 Diseases of external ear
0.910 0.090 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.909 0.091 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.908 0.092 0.000
J34.8 Other specified disorders of nose and nasal sinuses
0.908 0.092 0.000
M47.97 Spondylosis, unspecified (Lumbosacral region)
0.900 0.100 0.000
M43 Other deforming dorsopathies
0.898 0.102 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.898 0.102 0.000
M81.99 Osteoporosis, unspecified (Site unspecified)
0.897 0.103 0.000
M23.23 Derangement of meniscus due to old tear or injury (Medial collateral ligament or Other and unspecified medial meniscus)
0.897 0.103 0.000
M81.90 Osteoporosis, unspecified (Multiple sites)
0.896 0.104 0.000
S40-S49 Injuries to the shoulder and upper arm
0.891 0.109 0.000
M54.50 Low back pain (Multiple sites in spine)
0.886 0.114 0.000
S20-S29 Injuries to the thorax
0.885 0.115 0.000
M47.2 Other spondylosis with radiculopathy
0.882 0.118 0.000
Y42.5 Other oestrogens and progestogens
0.879 0.121 0.000
M54.57 Low back pain (Lumbosacral region)
0.873 0.127 0.000
H65 Nonsuppurative otitis media
0.872 0.128 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.870 0.130 0.000
M47.99 Spondylosis, unspecified (Site unspecified)
0.870 0.130 0.000
M21 Other acquired deformities of limbs
0.853 0.147 0.000
K10 Other diseases of jaws
0.852 0.148 0.000
S82 Fracture of lower leg, including ankle
0.851 0.149 0.000
J32 Chronic sinusitis
0.850 0.150 0.000
M54.9 Dorsalgia, unspecified
0.847 0.152 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.845 0.155 0.000
M45 Ankylosing spondylitis
0.845 0.155 0.000
H72 Perforation of tympanic membrane
0.844 0.156 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.843 0.157 0.000
G30-G32 Other degenerative diseases of the nervous system
0.842 0.158 0.000
M54.1 Radiculopathy
0.841 0.159 0.000
M43.1 Spondylolisthesis
0.839 0.161 0.000
Q60-Q64 Congenital malformations of the urinary system
0.836 0.164 0.000
S50-S59 Injuries to the elbow and forearm
0.834 0.166 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.833 0.167 0.000
K02 Dental caries
0.832 0.168 0.000
S90-S99 Injuries to the ankle and foot
0.829 0.171 0.000
H80-H83 Diseases of inner ear
0.827 0.173 0.000
Y86 Sequelae of other accidents
0.827 0.173 0.000
S40 Superficial injury of shoulder and upper arm
0.827 0.173 0.000
M46 Other inflammatory spondylopathies
0.825 0.175 0.000
M47.26 Other spondylosis with radiculopathy (Lumbar region)
0.825 0.175 0.000
V80-V89 Other land transport accidents
0.824 0.176 0.000
H74.9 Disorder of middle ear and mastoid, unspecified
0.824 0.176 0.000
M54.4 Lumbago with sciatica
0.822 0.178 0.000
H60 Otitis externa
0.813 0.187 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.809 0.191 0.000
J60-J70 Lung diseases due to external agents
0.806 0.194 0.000
M54.3 Sciatica
0.802 0.198 0.000
T79-T79 Certain early complications of trauma
0.801 0.199 0.000
M54.2 Cervicalgia
0.800 0.200 0.000
J34.0 Abscess, furuncle and carbuncle of nose
0.798 0.202 0.000
K51.5 Mucosal proctocolitis
0.796 0.204 0.000
H90-H95 Other disorders of ear
0.796 0.204 0.000
H74.0 Tympanosclerosis
0.795 0.205 0.000
H65.9 Nonsuppurative otitis media, unspecified
0.795 0.205 0.000
M24.13 Other articular cartilage disorders (Forearm)
0.794 0.206 0.000
G20-G26 Extrapyramidal and movement disorders
0.794 0.206 0.000
S82.1 Fracture of upper end of tibia
0.794 0.206 0.000
M47.90 Spondylosis, unspecified (Multiple sites in spine)
0.793 0.206 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.793 0.207 0.000
M80 Osteoporosis with pathological fracture
0.790 0.210 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.789 0.211 0.000
J33.9 Nasal polyp, unspecified
0.789 0.211 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.788 0.212 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.788 0.212 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.787 0.213 0.000
G90-G99 Other disorders of the nervous system
0.787 0.213 0.000
M22 Disorders of patella
0.786 0.214 0.000
Y45.1 Salicylates
0.786 0.214 0.000
S81 Open wound of lower leg
0.785 0.215 0.000
S40.9 Superficial injury of shoulder and upper arm, unspecified
0.785 0.215 0.000
K02.9 Dental caries, unspecified
0.785 0.215 0.000
W20-W49 Exposure to inanimate mechanical forces
0.784 0.216 0.000
K10.8 Other specified diseases of jaws
0.784 0.216 0.000
M60-M63 Disorders of muscles
0.784 0.216 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.784 0.216 0.000
M23.25 Derangement of meniscus due to old tear or injury (Posterior horn of lateral meniscus)
0.782 0.218 0.000
M23.22 Derangement of meniscus due to old tear or injury (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.782 0.218 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.781 0.219 0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.781 0.219 0.000
M23.4 Loose body in knee
0.780 0.220 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.778 0.222 0.000
M43.17 Spondylolisthesis (Lumbosacral region)
0.778 0.222 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.776 0.224 0.000
X60-X84 Intentional self-harm
0.776 0.224 0.000
H72.9 Perforation of tympanic membrane, unspecified
0.775 0.225 0.000
M47.1 Other spondylosis with myelopathy
0.775 0.225 0.000
K51.2 Ulcerative (chronic) proctitis
0.775 0.225 0.000
M23.0 Cystic meniscus
0.773 0.227 0.000
M84 Disorders of continuity of bone
0.771 0.229 0.000
V40-V49 Car occupant injured in transport accident
0.769 0.231 0.000
H73 Other disorders of tympanic membrane
0.768 0.232 0.000
V20-V29 Motorcycle rider injured in transport accident
0.767 0.233 0.000
H74.3 Other acquired abnormalities of ear ossicles
0.766 0.234 0.000
M35 Other systemic involvement of connective tissue
0.766 0.234 0.000
M53 Other dorsopathies, not elsewhere classified
0.764 0.236 0.000
M41 Scoliosis
0.761 0.239 0.000
X50-X57 Overexertion, travel and privation
0.759 0.241 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.759 0.241 0.000
S80 Superficial injury of lower leg
0.757 0.243 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.757 0.243 0.000
K11 Diseases of salivary glands
0.755 0.245 0.000
M81.4 Drug-induced osteoporosis
0.755 0.245 0.000
Q61 Cystic kidney disease
0.754 0.246 0.000
M24.2 Disorder of ligament
0.753 0.247 0.000
S82.10 Fracture of upper end of tibia (closed)
0.752 0.248 0.000
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.752 0.248 0.000
M23.9 Internal derangement of knee, unspecified
0.750 0.250 0.000
K51.4 Pseudopolyposis of colon
0.750 0.250 0.000
H74.4 Polyp of middle ear
0.748 0.252 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.748 0.252 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.748 0.252 0.000
J39 Other diseases of upper respiratory tract
0.748 0.252 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.747 0.252 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.747 0.253 0.000
H83 Other diseases of inner ear
0.747 0.253 0.000
K55-K64 Other diseases of intestines
0.746 0.254 0.000
T39.1 4-Aminophenol derivatives
0.746 0.254 0.000
H90 Conductive and sensorineural hearing loss
0.745 0.255 0.000
Chapter I Certain infectious and parasitic diseases
0.745 0.255 0.000
Q80-Q89 Other congenital malformations
0.744 0.256 0.000
H61 Other disorders of external ear
0.744 0.256 0.000
S89 Other and unspecified injuries of lower leg
0.742 0.258 0.000
T36 Poisoning by systemic antibiotics
0.740 0.259 0.000
K05 Gingivitis and periodontal diseases
0.740 0.260 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.740 0.260 0.000
K51.8 Other ulcerative colitis
0.738 0.262 0.000
Y88 Sequelae of surgical and medical care as external cause
0.735 0.265 0.000
M86-M90 Other osteopathies
0.734 0.266 0.000
M00-M03 Infectious arthropathies
0.734 0.266 0.000
M54.58 Low back pain (Sacral and sacrococcygeal region)
0.733 0.267 0.000
M21.2 Flexion deformity
0.732 0.268 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.732 0.268 0.000
S82.2 Fracture of shaft of tibia
0.732 0.268 0.000
K80-K87 Disorders of gallbladder, biliary tract and pancreas
0.731 0.269 0.000
S29 Other and unspecified injuries of thorax
0.728 0.272 0.000
S20 Superficial injury of thorax
0.727 0.273 0.000
T66-T78 Other and unspecified effects of external causes
0.726 0.274 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.726 0.274 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.725 0.275 0.000
M40 Kyphosis and lordosis
0.724 0.276 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.723 0.277 0.000
S50 Superficial injury of forearm
0.723 0.277 0.000
S10-S19 Injuries to the neck
0.721 0.278 0.000
K46 Unspecified abdominal hernia
0.721 0.279 0.000
V10-V19 Pedal cyclist injured in transport accident
0.721 0.279 0.000
J47 Bronchiectasis
0.718 0.282 0.000
Y40 Systemic antibiotics
0.718 0.282 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
J37 Chronic laryngitis and laryngotracheitis
0.717 0.283 0.000
H71 Cholesteatoma of middle ear
0.717 0.283 0.000
T33-T35 Frostbite
0.716 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.716 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.716 0.283 0.000
T90 Sequelae of injuries of head
0.716 0.283 0.000
Y35-Y36 Legal intervention and operations of war
0.716 0.284 0.000
Y10-Y34 Event of undetermined intent
0.716 0.284 0.000
Y00-Y09 Assault
0.716 0.284 0.000
X85-X99 Assault
0.716 0.284 0.000
X30-X39 Exposure to forces of nature
0.716 0.284 0.000
X10-X19 Contact with heat and hot substances
0.716 0.284 0.000
X00-X09 Exposure to smoke, fire and flames
0.716 0.284 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.716 0.284 0.000
W75-W84 Other accidental threats to breathing
0.716 0.284 0.000
W65-W74 Accidental drowning and submersion
0.716 0.284 0.000
W50-W64 Exposure to animate mechanical forces
0.716 0.284 0.000
V98-V99 Other and unspecified transport accidents
0.716 0.284 0.000
V95-V97 Air and space transport accidents
0.716 0.284 0.000
V90-V94 Water transport accidents
0.716 0.284 0.000
V70-V79 Bus occupant injured in transport accident
0.716 0.284 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.716 0.284 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.716 0.284 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.716 0.284 0.000
V01-V09 Pedestrian injured in transport accident
0.716 0.284 0.000
Chapter XXII Codes for special purposes
0.715 0.284 0.000
M54.8 Other dorsalgia
0.715 0.285 0.000
M54.0 Panniculitis affecting regions of neck and back
0.715 0.285 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.714 0.286 0.000
M33 Dermatopolymyositis
0.714 0.286 0.000
M32 Systemic lupus erythematosus
0.714 0.286 0.000
M30 Polyarteritis nodosa and related conditions
0.714 0.286 0.000
S86 Injury of muscle and tendon at lower leg level
0.714 0.286 0.000
M46.4 Discitis, unspecified
0.714 0.286 0.000
M81.95 Osteoporosis, unspecified (Pelvic region and thigh)
0.713 0.287 0.000
K57 Diverticular disease of intestine
0.713 0.287 0.000
J32.2 Chronic ethmoidal sinusitis
0.712 0.288 0.000
K51.1 Ulcerative (chronic) ileocolitis
0.712 0.288 0.000
M54.55 Low back pain (Thoracolumbar region)
0.712 0.288 0.000
M54.54 Low back pain-Thoracic
0.712 0.288 0.000
M54.53 Low back pain-Cervicothoracic
0.712 0.288 0.000
M54.52 Low back pain-Cervical
0.712 0.288 0.000
M54.51 Low back pain-Occipit-atl-axl
0.712 0.288 0.000
M49 Spondylopathies in diseases classified elsewhere
0.711 0.288 0.000
M85 Other disorders of bone density and structure
0.711 0.289 0.000
J32.0 Chronic maxillary sinusitis
0.711 0.289 0.000
M54.98 Dorsalgia, unspecified (Sacral and sacrococcygeal region)
0.710 0.290 0.000
M47.96 Spondylosis, unspecified (Lumbar region)
0.710 0.290 0.000
M24.5 Contracture of joint
0.709 0.290 0.000
Y45.2 Propionic acid derivatives
0.709 0.291 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.709 0.291 0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.708 0.292 0.000
H70 Mastoiditis and related conditions
0.708 0.292 0.000
H68 Eustachian salpingitis and obstruction
0.708 0.292 0.000
H67 Otitis media in diseases classified elsewhere
0.708 0.292 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.707 0.293 0.000
H66 Suppurative and unspecified otitis media
0.707 0.293 0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.707 0.293 0.000
G70-G73 Diseases of myoneural junction and muscle
0.706 0.294 0.000
M83 Adult osteomalacia
0.706 0.294 0.000
M82 Osteoporosis in diseases classified elsewhere
0.706 0.294 0.000
Y52 Agents primarily affecting the cardiovascular system
0.704 0.296 0.000
K10.2 Inflammatory conditions of jaws
0.704 0.296 0.000
M23.5 Chronic instability of knee
0.704 0.296 0.000
S70-S79 Injuries to the hip and thigh
0.703 0.297 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.703 0.297 0.000
M54.19 Radiculopathy (Site unspecified)
0.703 0.297 0.000
K57.9 Diverticular disease of intestine, part unspecified, without perforation or abscess
0.703 0.297 0.000
K63 Other diseases of intestine
0.703 0.297 0.000
X59 Exposure to unspecified factor
0.702 0.298 0.000
K42 Umbilical hernia
0.702 0.298 0.000
Y59 Other and unspecified vaccines and biological substances
0.701 0.298 0.000
Y58 Bacterial vaccines
0.701 0.298 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.701 0.298 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.701 0.298 0.000
Y48 Anaesthetics and therapeutic gases
0.701 0.298 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.701 0.298 0.000
H69 Other disorders of Eustachian tube
0.701 0.299 0.000
M47.0 Anterior spinal and vertebral artery compression syndromes
0.701 0.299 0.000
M24.9 Joint derangement, unspecified
0.699 0.301 0.000
M24.7 Protrusio acetabuli
0.699 0.301 0.000
M24.6 Ankylosis of joint
0.699 0.301 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.699 0.301 0.000
M15-M19 Arthrosis
0.699 0.301 0.000
T98 Sequelae of other and unspecified effects of external causes
0.699 0.301 0.000
J69 Pneumonitis due to solids and liquids
0.699 0.301 0.000
V89 Motor- or nonmotor-vehicle accident, type of vehicle unspecified
0.699 0.301 0.000
J35 Chronic diseases of tonsils and adenoids
0.699 0.301 0.000
X20-X29 Contact with venomous animals and plants
0.699 0.301 0.000
J41 Simple and mucopurulent chronic bronchitis
0.698 0.301 0.000
J33.1 Polypoid sinus degeneration
0.698 0.301 0.000
M24.17 Other articular cartilage disorders (Ankle and foot)
0.698 0.302 0.000
H65.2 Chronic serous otitis media
0.698 0.302 0.000
M43.6 Torticollis
0.697 0.303 0.000
G25 Other extrapyramidal and movement disorders
0.697 0.303 0.000
M54.99 Dorsalgia, unspecified (Site unspecified)
0.697 0.303 0.000
W00-W19 Falls
0.696 0.304 0.000
M23.1 Discoid meniscus (congenital)
0.693 0.307 0.000
M91-M94 Chondropathies
0.693 0.307 0.000
K85 Acute pancreatitis
0.692 0.308 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.692 0.308 0.000
G30 Alzheimer's disease
0.692 0.308 0.000
K45 Other abdominal hernia
0.692 0.308 0.000
M23.24 Derangement of meniscus due to old tear or injury (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.691 0.308 0.000
M81.8 Other osteoporosis
0.691 0.309 0.000
M81.6 Localised osteoporosis [Lequesne]
0.691 0.309 0.000
M81.5 Idiopathic osteoporosis
0.691 0.309 0.000
M81.3 Postsurgical malabsorption osteoporosis
0.691 0.309 0.000
M81.2 Osteoporosis of disuse
0.691 0.309 0.000
M81.1 Postoophorectomy osteoporosis
0.691 0.309 0.000
M81.0 Postmenopausal osteoporosis
0.691 0.309 0.000
S88 Traumatic amputation of lower leg
0.691 0.309 0.000
S87 Crushing injury of lower leg
0.691 0.309 0.000
S85 Injury of blood vessels at lower leg level
0.691 0.309 0.000
S84 Injury of nerves at lower leg level
0.691 0.309 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.690 0.310 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.690 0.310 0.000
K06 Other disorders of gingiva and edentulous alveolar ridge
0.690 0.310 0.000
H83.0 Labyrinthitis
0.689 0.311 0.000
Y49.0 Tricyclic and tetracyclic antidepressants
0.688 0.312 0.000
H60.9 Otitis externa, unspecified
0.687 0.313 0.000
S41 Open wound of shoulder and upper arm
0.685 0.315 0.000
M24.0 Loose body in joint
0.685 0.315 0.000
A30-A49 Other bacterial diseases
0.684 0.316 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.684 0.316 0.000
Y76 Obstetric and gynaecological devices associated with adverse incidents
0.684 0.316 0.000
T93 Sequelae of injuries of lower limb
0.684 0.316 0.000
M47.98 Spondylosis, unspecified (Sacral and sacrococcygeal region)
0.683 0.316 0.000
M47.95 Spondylosis, unspecified (Thoracolumbar region)
0.683 0.316 0.000
M47.94 Spondylosis, unspecified (Thoracic region)
0.683 0.316 0.000
M47.93 Spondylosis, unspecified (Cervicothoracic region)
0.683 0.316 0.000
M47.91 Spondylosis, unspecified (Occipito-atlanto-axial region)
0.683 0.316 0.000
M43.0 Spondylolysis
0.683 0.316 0.000
M42 Spinal osteochondrosis
0.683 0.316 0.000
H74.8 Other specified disorders of middle ear and mastoid
0.683 0.317 0.000
Y45.0 Opioids and related analgesics
0.681 0.319 0.000
Y79 Orthopaedic devices associated with adverse incidents
0.681 0.319 0.000
M24.19 Other articular cartilage disorders (Site unspecified)
0.680 0.320 0.000
M24.18 Other articular cartilage disorders (Other)
0.680 0.320 0.000
M24.14 Other articular cartilage disorders (Hand)
0.680 0.320 0.000
M24.12 Other articular cartilage disorders (Upper arm)
0.680 0.320 0.000
M24.10 Other articular cartilage disorders (Multiple sites)
0.680 0.320 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.679 0.321 0.000
S90 Superficial injury of ankle and foot
0.678 0.322 0.000
S82.0 Fracture of patella
0.678 0.322 0.000
Q61.2 Polycystic kidney, adult type
0.678 0.322 0.000
M81.97 Osteoporosis, unspecified (Ankle and foot)
0.677 0.323 0.000
M81.96 Osteoporosis, unspecified (Lower leg)
0.677 0.323 0.000
M81.94 Osteoporosis, unspecified (Hand)
0.677 0.323 0.000
M81.93 Osteoporosis, unspecified (Forearm)
0.677 0.323 0.000
M81.92 Osteoporosis, unspecified (Upper arm)
0.677 0.323 0.000
M81.91 Osteoporosis, unspecified (Shoulder region)
0.677 0.323 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.677 0.323 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.677 0.323 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.677 0.323 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.677 0.323 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.677 0.323 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.677 0.323 0.000
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.677 0.323 0.000
H74.2 Discontinuity and dislocation of ear ossicles
0.677 0.323 0.000
H74.1 Adhesive middle ear disease
0.677 0.323 0.000
J32.8 Other chronic sinusitis
0.675 0.325 0.000
Y57 Other and unspecified drugs and medicaments
0.674 0.326 0.000
M21.3 Wrist or foot drop (acquired)
0.674 0.326 0.000
J38.3 Other diseases of vocal cords
0.673 0.327 0.000
M54.39 Sciatica (Site unspecified)
0.673 0.327 0.000
Q21 Congenital malformations of cardiac septa
0.671 0.329 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.671 0.329 0.000
Q35-Q37 Cleft lip and cleft palate
0.671 0.329 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.671 0.329 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.670 0.329 0.000
G12 Spinal muscular atrophy and related syndromes
0.670 0.330 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.670 0.330 0.000
G91 Hydrocephalus
0.669 0.331 0.000
K43.7 Other and unspecified ventral hernia with gangrene
0.669 0.331 0.000
K43.6 Other and unspecified ventral hernia with obstruction, without gangrene
0.669 0.331 0.000
K43.5 Parastomal hernia without obstruction or gangrene
0.669 0.331 0.000
K43.4 Parastomal hernia with gangrene
0.669 0.331 0.000
K43.3 Parastomal hernia with obstruction, without gangrene
0.669 0.331 0.000
K43.2 Incisional hernia without obstruction or gangrene
0.669 0.331 0.000
K43.1 Ventral hernia with gangrene
0.669 0.331 0.000
M35.0 Sicca syndrome [Sjogren]
0.668 0.332 0.000
G03 Meningitis due to other and unspecified causes
0.667 0.333 0.000
M24.11 Other articular cartilage disorders (Shoulder region)
0.667 0.333 0.000
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
0.665 0.335 0.000
K09 Cysts of oral region, not elsewhere classified
0.664 0.336 0.000
M54.46 Lumbago with sciatica (Lumbar region)
0.663 0.337 0.000
K51.0 Ulcerative (chronic) enterocolitis
0.663 0.337 0.000
M48 Other spondylopathies
0.662 0.338 0.000
M45.X9 Ankylosing spondylitis (Site unspecified)
0.660 0.340 0.000
S83.3 Tear of articular cartilage of knee, current
0.660 0.340 0.000
M43.19 Spondylolisthesis (Site unspecified)
0.660 0.340 0.000
M23.27 Derangement of meniscus due to old tear or injury-Capsular
0.659 0.341 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.659 0.341 0.000
H61.2 Impacted cerumen
0.658 0.342 0.000
Y42.9 Other and unspecified hormone antagonists
0.657 0.342 0.000
Y42.8 Other and unspecified hormones and their synthetic substitutes
0.657 0.342 0.000
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified
0.657 0.342 0.000
Y42.4 Oral contraceptives
0.657 0.342 0.000
Y42.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.657 0.342 0.000
Y42.2 Antithyroid drugs
0.657 0.342 0.000
Y42.1 Thyroid hormones and substitutes
0.657 0.342 0.000
Y42.0 Glucocorticoids and synthetic analogs
0.657 0.342 0.000
Y44 Agents primarily affecting blood constituents
0.657 0.343 0.000
S56 Injury of muscle and tendon at forearm level
0.657 0.343 0.000
K01 Embedded and impacted teeth
0.655 0.345 0.000
Y89 Sequelae of other external causes
0.655 0.345 0.000
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent
0.655 0.345 0.000
J32.4 Chronic pansinusitis
0.654 0.345 0.000
K63.9 Disease of intestine, unspecified
0.654 0.346 0.000
H60.3 Other infective otitis externa
0.654 0.346 0.000
H62 Disorders of external ear in diseases classified elsewhere
0.653 0.347 0.000
M19 Other arthrosis
0.652 0.348 0.000
K03 Other diseases of hard tissues of teeth
0.652 0.348 0.000
Y85 Sequelae of transport accidents
0.652 0.348 0.000
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified
0.651 0.349 0.000
Y45.8 Other analgesics and antipyretics
0.651 0.349 0.000
Y45.5 4-Aminophenol derivatives
0.651 0.349 0.000
Y45.4 Antirheumatics
0.651 0.349 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.650 0.350 0.000
Y53.1 Other antacids and anti-gastric-secretion drugs
0.650 0.350 0.000
K04 Diseases of pulp and periapical tissues
0.650 0.350 0.000
Q00-Q07 Congenital malformations of the nervous system
0.649 0.351 0.000
Q50-Q56 Congenital malformations of genital organs
0.649 0.351 0.000
M54.94 Dorsalgia, unspecified (Thoracic region)
0.648 0.351 0.000
M22.2 Patellofemoral disorders
0.648 0.352 0.000
M80.8 Other osteoporosis with pathological fracture
0.647 0.352 0.000
G31.9 Degenerative disease of nervous system, unspecified
0.647 0.353 0.000
M23.49 Loose body in knee-Unspec lig/men
0.647 0.353 0.000
K85.1 Biliary acute pancreatitis
0.646 0.354 0.000
M54.6 Pain in thoracic spine
0.646 0.354 0.000
G90 Disorders of autonomic nervous system
0.646 0.354 0.000
E00-E07 Disorders of thyroid gland
0.644 0.356 0.000
M23.3 Other meniscus derangements
0.644 0.356 0.000
M43.9 Deforming dorsopathy, unspecified
0.644 0.356 0.000
M43.8 Other specified deforming dorsopathies
0.644 0.356 0.000
M43.5 Other recurrent vertebral subluxation
0.644 0.356 0.000
M43.4 Other recurrent atlantoaxial subluxation
0.644 0.356 0.000
M43.3 Recurrent atlantoaxial subluxation with myelopathy
0.644 0.356 0.000
M43.2 Other fusion of spine
0.644 0.356 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.644 0.356 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.644 0.356 0.000
T39.4 Antirheumatics, not elsewhere classified
0.644 0.356 0.000
T39.2 Pyrazolone derivatives
0.644 0.356 0.000
T39.0 Salicylates
0.644 0.356 0.000
M54.29 Cervicalgia-Site unspe
0.644 0.356 0.000
S50.9 Superficial injury of forearm, unspecified
0.642 0.357 0.000
M34 Systemic sclerosis
0.642 0.358 0.000
Q61.3 Polycystic kidney, unspecified
0.641 0.359 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.641 0.359 0.000
Y46.4 Iminostilbenes
0.640 0.360 0.000
M54.18 Radiculopathy (Sacral and sacrococcygeal region)
0.639 0.361 0.000
S48 Traumatic amputation of shoulder and upper arm
0.639 0.361 0.000
S45 Injury of blood vessels at shoulder and upper arm level
0.639 0.361 0.000
S44 Injury of nerves at shoulder and upper arm level
0.639 0.361 0.000
S47 Crushing injury of shoulder and upper arm
0.639 0.361 0.000
Q63 Other congenital malformations of kidney
0.639 0.361 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.637 0.363 0.000
M54.49 Lumbago with sciatica (Site unspecified)
0.637 0.363 0.000
M22.8 Other disorders of patella
0.635 0.365 0.000
S28 Crushing injury of thorax and traumatic amputation of part of thorax
0.634 0.365 0.000
S26 Injury of heart
0.634 0.365 0.000
S25 Injury of blood vessels of thorax
0.634 0.365 0.000
S24 Injury of nerves and spinal cord at thorax level
0.634 0.365 0.000
S23 Dislocation, sprain and strain of joints and ligaments of thorax
0.634 0.365 0.000
S21 Open wound of thorax
0.634 0.365 0.000
M46.46 Discitis, unspecified (Lumbar region)
0.634 0.366 0.000
H65.4 Other chronic nonsuppurative otitis media
0.634 0.366 0.000
M23.06 Cystic meniscus (Other and unspecified lateral meniscus)
0.633 0.366 0.000
M47.29 Other spondylosis with radiculopathy (Site unspecified)
0.632 0.368 0.000
M47.28 Other spondylosis with radiculopathy (Sacral and sacrococcygeal region)
0.632 0.368 0.000
M47.27 Other spondylosis with radiculopathy (Lumbosacral region)
0.632 0.368 0.000
M47.25 Other spondylosis with radiculopathy (Thoracolumbar region)
0.632 0.368 0.000
M47.24 Other spondylosis with radiculopathy (Thoracic region)
0.632 0.368 0.000
M47.23 Other spondylosis with radiculopathy (Cervicothoracic region)
0.632 0.368 0.000
M47.21 Other spondylosis with radiculopathy (Occipito-atlanto-axial region)
0.632 0.368 0.000
M47.20 Other spondylosis with radiculopathy (Multiple sites in spine)
0.632 0.368 0.000
H60.8 Other otitis externa
0.631 0.369 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.630 0.370 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.630 0.370 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.630 0.370 0.000
M47.12 Other spondylosis with myelopathy (Cervical region)
0.630 0.370 0.000
M62 Other disorders of muscle
0.629 0.371 0.000
M21.26 Flexion deformity (Lower leg)
0.629 0.371 0.000
K42.0 Umbilical hernia with obstruction, without gangrene
0.628 0.372 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.626 0.374 0.000
J43 Emphysema
0.626 0.374 0.000
S99 Other and unspecified injuries of ankle and foot
0.626 0.374 0.000
T14 Injury of unspecified body region
0.626 0.374 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.626 0.374 0.000
H65.1 Other acute nonsuppurative otitis media
0.625 0.375 0.000
H65.0 Acute serous otitis media
0.625 0.375 0.000
M54.16 Radiculopathy (Lumbar region)
0.625 0.375 0.000
Chapter VII Diseases of the eye and adnexa
0.624 0.376 0.000
M35.1 Other overlap syndromes
0.624 0.376 0.000
T95 Sequelae of burns, corrosions and frostbite
0.624 0.376 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.624 0.376 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.624 0.376 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.624 0.376 0.000
M84.1 Nonunion of fracture [pseudarthrosis]
0.624 0.376 0.000
S42 Fracture of shoulder and upper arm
0.623 0.377 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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