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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3849590
log Bayes Factor = 13.7301
Chromosome 4   position 40,837,655  (GRCh37) Explore rs3849590 on Ensembl!
Variant rs3849590 is part of Cluster X0243

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter II Neoplasms
1.000 0.000 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
1.000 0.000 0.000
I84 Haemorrhoids
1.000 0.000 0.000
D10-D36 Benign neoplasms
0.999 0.001 0.000
I84.6 Residual haemorrhoidal skin tags
0.998 0.002 0.000
D25 Leiomyoma of uterus
0.998 0.002 0.000
D25.9 Leiomyoma of uterus, unspecified
0.997 0.003 0.000
M15-M19 Arthrosis
0.996 0.004 0.000
M20-M25 Other joint disorders
0.994 0.006 0.000
Chapter VII Diseases of the eye and adnexa
0.994 0.006 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.993 0.007 0.000
H30-H36 Disorders of choroid and retina
0.988 0.012 0.000
M19 Other arthrosis
0.975 0.025 0.000
Chapter VI Diseases of the nervous system
0.973 0.027 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.972 0.028 0.000
I30-I52 Other forms of heart disease
0.968 0.032 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.965 0.035 0.000
T81 Complications of procedures, not elsewhere classified
0.955 0.045 0.000
M25 Other joint disorders, not elsewhere classified
0.953 0.047 0.000
M19.9 Arthrosis, unspecified
0.952 0.048 0.000
I05-I09 Chronic rheumatic heart diseases
0.951 0.049 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.951 0.049 0.000
C64-C68 Malignant neoplasms of urinary tract
0.947 0.053 0.000
H33 Retinal detachments and breaks
0.945 0.055 0.000
H35 Other retinal disorders
0.943 0.057 0.000
I10-I15 Hypertensive diseases
0.941 0.059 0.000
M17 Gonarthrosis [arthrosis of knee]
0.932 0.068 0.000
D27 Benign neoplasm of ovary
0.930 0.070 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.928 0.072 0.000
I77 Other disorders of arteries and arterioles
0.924 0.076 0.000
Chapter I Certain infectious and parasitic diseases
0.921 0.079 0.000
I74 Arterial embolism and thrombosis
0.919 0.081 0.000
I84.8 Unspecified haemorrhoids with other complications
0.918 0.082 0.000
G55.1 Nerve root and plexus compressions in intervertebral disk disorders
0.914 0.086 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.909 0.091 0.000
M23 Internal derangement of knee
0.905 0.095 0.000
C67 Malignant neoplasm of bladder
0.904 0.096 0.000
I08 Multiple valve diseases
0.902 0.098 0.000
I10 Essential (primary) hypertension
0.900 0.100 0.000
T81.4 Infection following a procedure, not elsewhere classified
0.898 0.102 0.000
D00-D09 In situ neoplasms
0.896 0.104 0.000
M16 Coxarthrosis [arthrosis of hip]
0.892 0.108 0.000
M19.91 Arthrosis, unspecified (Shoulder region)
0.890 0.110 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.887 0.113 0.000
T81.3 Disruption of operation wound, not elsewhere classified
0.886 0.114 0.000
I84.2 Internal haemorrhoids without complication
0.886 0.114 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.884 0.116 0.000
M25.7 Osteophyte
0.882 0.118 0.000
I08.0 Disorders of both mitral and aortic valves
0.881 0.119 0.000
M70-M79 Other soft tissue disorders
0.881 0.119 0.000
H33.0 Retinal detachment with retinal break
0.880 0.120 0.000
M16.9 Coxarthrosis, unspecified
0.875 0.125 0.000
M17.0 Primary gonarthrosis, bilateral
0.874 0.126 0.000
I35 Nonrheumatic aortic valve disorders
0.871 0.129 0.000
M65-M68 Disorders of synovium and tendon
0.868 0.132 0.000
M45-M49 Spondylopathies
0.862 0.138 0.000
I34 Nonrheumatic mitral valve disorders
0.862 0.138 0.000
I51 Complications and ill-defined descriptions of heart disease
0.858 0.142 0.000
M24 Other specific joint derangements
0.857 0.143 0.000
D35 Benign neoplasm of other and unspecified endocrine glands
0.856 0.144 0.000
D11 Benign neoplasm of major salivary glands
0.856 0.144 0.000
C50-C50 Malignant neoplasm of breast
0.853 0.147 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.852 0.148 0.000
D26 Other benign neoplasms of uterus
0.850 0.150 0.000
I72 Other aneurysm
0.850 0.150 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.847 0.153 0.000
T87 Complications peculiar to reattachment and amputation
0.846 0.154 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.844 0.156 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.842 0.158 0.000
M23.8 Other internal derangements of knee
0.839 0.161 0.000
M19.97 Arthrosis, unspecified (Ankle and foot)
0.838 0.162 0.000
D30 Benign neoplasm of urinary organs
0.838 0.162 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.837 0.163 0.000
D25.2 Subserosal leiomyoma of uterus
0.835 0.165 0.000
M21 Other acquired deformities of limbs
0.835 0.165 0.000
H34 Retinal vascular occlusions
0.834 0.166 0.000
M35 Other systemic involvement of connective tissue
0.833 0.167 0.000
I44 Atrioventricular and left bundle-branch block
0.831 0.169 0.000
H35.3 Degeneration of macula and posterior pole
0.822 0.178 0.000
I51.8 Other ill-defined heart diseases
0.821 0.179 0.000
H33.3 Retinal breaks without detachment
0.819 0.181 0.000
I84.7 Unspecified thrombosed haemorrhoids
0.817 0.183 0.000
I78 Diseases of capillaries
0.815 0.185 0.000
B35-B49 Mycoses
0.814 0.186 0.000
H10-H13 Disorders of conjunctiva
0.814 0.186 0.000
I84.0 Internal thrombosed haemorrhoids
0.813 0.187 0.000
I05 Rheumatic mitral valve diseases
0.812 0.188 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.808 0.192 0.000
M40-M43 Deforming dorsopathies
0.805 0.194 0.000
I71 Aortic aneurysm and dissection
0.805 0.195 0.000
I83 Varicose veins of lower extremities
0.804 0.196 0.000
C79 Secondary malignant neoplasm of other sites
0.802 0.198 0.000
D14 Benign neoplasm of middle ear and respiratory system
0.802 0.198 0.000
S50-S59 Injuries to the elbow and forearm
0.802 0.198 0.000
M25.77 Osteophyte (Ankle and foot)
0.801 0.199 0.000
C34 Malignant neoplasm of bronchus and lung
0.800 0.199 0.000
Chapter XX External causes of morbidity and mortality
0.800 0.200 0.000
I84.5 External haemorrhoids without complication
0.799 0.201 0.000
H35.8 Other specified retinal disorders
0.795 0.205 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.795 0.205 0.000
M31 Other necrotising vasculopathies
0.794 0.206 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.793 0.207 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.792 0.208 0.000
I77.8 Other specified disorders of arteries and arterioles
0.790 0.210 0.000
M19.0 Primary arthrosis of other joints
0.787 0.213 0.000
G50 Disorders of trigeminal nerve
0.786 0.214 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.784 0.216 0.000
M25.9 Joint disorder, unspecified
0.783 0.217 0.000
I84.1 Internal haemorrhoids with other complications
0.783 0.217 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.781 0.219 0.000
H55-H59 Other disorders of eye and adnexa
0.778 0.222 0.000
T81.1 Shock during or resulting from a procedure, not elsewhere classified
0.777 0.223 0.000
M19.99 Arthrosis, unspecified (Site unspecified)
0.776 0.224 0.000
H53-H54 Visual disturbances and blindness
0.775 0.225 0.000
I77.1 Stricture of artery
0.774 0.226 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.772 0.228 0.000
B95-B98 Bacterial, viral and other infectious agents
0.772 0.228 0.000
C51-C58 Malignant neoplasms of female genital organs
0.771 0.229 0.000
C67.3 Anterior wall of bladder
0.771 0.229 0.000
I84.4 External haemorrhoids with other complications
0.770 0.230 0.000
H31 Other disorders of choroid
0.770 0.230 0.000
D10 Benign neoplasm of mouth and pharynx
0.769 0.231 0.000
M25.75 Osteophyte (Pelvic region and thigh)
0.769 0.231 0.000
H35.7 Separation of retinal layers
0.768 0.232 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.767 0.233 0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.767 0.233 0.000
A30-A49 Other bacterial diseases
0.766 0.234 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.765 0.235 0.000
C66 Malignant neoplasm of ureter
0.765 0.235 0.000
C67.9 Bladder, unspecified
0.765 0.235 0.000
E70-E90 Metabolic disorders
0.765 0.235 0.000
C67.0 Trigone of bladder
0.764 0.236 0.000
I31 Other diseases of pericardium
0.763 0.237 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.762 0.238 0.000
D28 Benign neoplasm of other and unspecified female genital organs
0.761 0.239 0.000
D05 Carcinoma in situ of breast
0.760 0.240 0.000
G70-G73 Diseases of myoneural junction and muscle
0.758 0.242 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.754 0.246 0.000
I46 Cardiac arrest
0.754 0.246 0.000
D11.0 Parotid gland
0.753 0.247 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.753 0.247 0.000
M19.98 Arthrosis, unspecified (Other)
0.753 0.247 0.000
M25.8 Other specified joint disorders
0.752 0.248 0.000
I82 Other venous embolism and thrombosis
0.751 0.249 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.751 0.249 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.751 0.249 0.000
S20-S29 Injuries to the thorax
0.751 0.249 0.000
C43 Malignant melanoma of skin
0.750 0.250 0.000
M19.94 Arthrosis, unspecified (Hand)
0.749 0.251 0.000
M25.4 Effusion of joint
0.749 0.251 0.000
C50 Malignant neoplasm of breast
0.748 0.252 0.000
I72.4 Aneurysm of artery of lower extremity
0.748 0.252 0.000
M35.0 Sicca syndrome [Sjogren]
0.747 0.253 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.746 0.254 0.000
T81.9 Unspecified complication of procedure
0.745 0.255 0.000
I85 Oesophageal varices
0.745 0.255 0.000
D26.1 Corpus uteri
0.744 0.256 0.000
Chapter XXII Codes for special purposes
0.743 0.257 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.741 0.259 0.000
I35.9 Aortic valve disorder, unspecified
0.740 0.259 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.740 0.260 0.000
I77.9 Disorder of arteries and arterioles, unspecified
0.739 0.260 0.000
M86-M90 Other osteopathies
0.739 0.261 0.000
D21 Other benign neoplasms of connective and other soft tissue
0.738 0.262 0.000
H35.5 Hereditary retinal dystrophy
0.738 0.262 0.000
M05-M14 Inflammatory polyarthropathies
0.737 0.263 0.000
S10-S19 Injuries to the neck
0.737 0.263 0.000
S40-S49 Injuries to the shoulder and upper arm
0.733 0.267 0.000
E87.6 Hypokalaemia
0.732 0.268 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.730 0.269 0.000
M91-M94 Chondropathies
0.729 0.270 0.000
D24 Benign neoplasm of breast
0.729 0.271 0.000
I35.8 Other aortic valve disorders
0.728 0.271 0.000
D07 Carcinoma in situ of other and unspecified genital organs
0.728 0.272 0.000
I86 Varicose veins of other sites
0.727 0.273 0.000
D03 Melanoma in situ
0.727 0.273 0.000
I34.0 Mitral (valve) insufficiency
0.727 0.273 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.726 0.273 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.726 0.274 0.000
D35.0 Adrenal gland
0.726 0.274 0.000
D12 Benign neoplasm of colon, rectum, anus and anal canal
0.724 0.276 0.000
I34.1 Mitral (valve) prolapse
0.724 0.276 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.723 0.277 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.723 0.277 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.722 0.277 0.000
T87.4 Infection of amputation stump
0.722 0.278 0.000
C67.5 Bladder neck
0.722 0.278 0.000
D30.3 Bladder
0.722 0.278 0.000
I38 Endocarditis, valve unspecified
0.722 0.278 0.000
M19.95 Arthrosis, unspecified (Pelvic region and thigh)
0.721 0.279 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.721 0.279 0.000
I44.6 Other and unspecified fascicular block
0.720 0.280 0.000
M67 Other disorders of synovium and tendon
0.719 0.281 0.000
I45 Other conduction disorders
0.718 0.282 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.718 0.282 0.000
I87 Other disorders of veins
0.717 0.283 0.000
M17.3 Other posttraumatic gonarthrosis
0.717 0.283 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.717 0.283 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.717 0.283 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I88 Nonspecific lymphadenitis
0.717 0.283 0.000
I81 Portal vein thrombosis
0.717 0.283 0.000
I70 Atherosclerosis
0.717 0.283 0.000
D31 Benign neoplasm of eye and adnexa
0.716 0.284 0.000
D29 Benign neoplasm of male genital organs
0.716 0.284 0.000
D20 Benign neoplasm of soft tissue of retroperitoneum and peritoneum
0.716 0.284 0.000
D19 Benign neoplasm of mesothelial tissue
0.716 0.284 0.000
D16 Benign neoplasm of bone and articular cartilage
0.716 0.284 0.000
D15 Benign neoplasm of other and unspecified intrathoracic organs
0.716 0.284 0.000
Chapter X Diseases of the respiratory system
0.716 0.284 0.000
I74.5 Embolism and thrombosis of iliac artery
0.715 0.285 0.000
M15 Polyarthrosis
0.714 0.286 0.000
T81.2 Accidental puncture and laceration during a procedure, not elsewhere classified
0.713 0.287 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.713 0.287 0.000
M34 Systemic sclerosis
0.713 0.287 0.000
M33 Dermatopolymyositis
0.713 0.287 0.000
M32 Systemic lupus erythematosus
0.713 0.287 0.000
M30 Polyarteritis nodosa and related conditions
0.713 0.287 0.000
S70-S79 Injuries to the hip and thigh
0.713 0.287 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.712 0.288 0.000
M65 Synovitis and tenosynovitis
0.711 0.289 0.000
T81.0 Haemorrhage and haematoma complicating a procedure, not elsewhere classified
0.711 0.289 0.000
H35.4 Peripheral retinal degeneration
0.709 0.291 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.709 0.291 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.708 0.292 0.000
H30 Chorioretinal inflammation
0.708 0.292 0.000
H52 Disorders of refraction and accommodation
0.708 0.292 0.000
M23.89 Other internal derangements of knee (Unspecified ligament or Unspecified meniscus)
0.708 0.292 0.000
G58 Other mononeuropathies
0.707 0.293 0.000
I47 Paroxysmal tachycardia
0.706 0.294 0.000
B37 Candidiasis
0.706 0.294 0.000
M50-M54 Other dorsopathies
0.704 0.296 0.000
M46 Other inflammatory spondylopathies
0.703 0.297 0.000
M22 Disorders of patella
0.702 0.298 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.702 0.298 0.000
H40-H42 Glaucoma
0.702 0.298 0.000
C77.5 Intrapelvic lymph nodes
0.702 0.298 0.000
M45 Ankylosing spondylitis
0.700 0.300 0.000
M23.83 Other internal derangements of knee (Medial collateral ligament or Other and unspecified medial meniscus)
0.700 0.300 0.000
M17.1 Other primary gonarthrosis
0.700 0.300 0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters
0.699 0.301 0.000
M19.8 Other specified arthrosis
0.699 0.301 0.000
M19.2 Other secondary arthrosis
0.699 0.301 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.697 0.302 0.000
T79-T79 Certain early complications of trauma
0.697 0.303 0.000
T33-T35 Frostbite
0.697 0.303 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.697 0.303 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.697 0.303 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.697 0.303 0.000
T00-T07 Injuries involving multiple body regions
0.697 0.303 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.697 0.303 0.000
G62 Other polyneuropathies
0.696 0.304 0.000
M19.1 Posttraumatic arthrosis of other joints
0.695 0.305 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.695 0.305 0.000
D05.9 Carcinoma in situ of breast, unspecified
0.694 0.306 0.000
I52 Other heart disorders in diseases classified elsewhere
0.694 0.306 0.000
I48 Atrial fibrillation and flutter
0.694 0.306 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.694 0.306 0.000
I41 Myocarditis in diseases classified elsewhere
0.694 0.306 0.000
I40 Acute myocarditis
0.694 0.306 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.694 0.306 0.000
I37 Pulmonary valve disorders
0.694 0.306 0.000
I36 Nonrheumatic tricuspid valve disorders
0.694 0.306 0.000
I32 Pericarditis in diseases classified elsewhere
0.694 0.306 0.000
I30 Acute pericarditis
0.694 0.306 0.000
I05.9 Mitral valve disease, unspecified
0.693 0.307 0.000
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.693 0.307 0.000
T82.0 Mechanical complication of heart valve prosthesis
0.692 0.308 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.692 0.308 0.000
T86 Failure and rejection of transplanted organs and tissues
0.692 0.308 0.000
M75 Shoulder lesions
0.692 0.308 0.000
M71 Other bursopathies
0.690 0.310 0.000
I77.6 Arteritis, unspecified
0.690 0.310 0.000
M31.3 Wegener's granulomatosis
0.690 0.310 0.000
M16.7 Other secondary coxarthrosis
0.689 0.310 0.000
H34.8 Other retinal vascular occlusions
0.689 0.311 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.688 0.312 0.000
M16.3 Other dysplastic coxarthrosis
0.688 0.312 0.000
C77.0 Lymph nodes of head, face and neck
0.687 0.313 0.000
I78.1 Naevus, nonneoplastic
0.687 0.313 0.000
M80-M85 Disorders of bone density and structure
0.686 0.314 0.000
H11 Other disorders of conjunctiva
0.685 0.314 0.000
T81.7 Vascular complications following a procedure, not elsewhere classified
0.685 0.315 0.000
T81.6 Acute reaction to foreign substance accidentally left during a procedure
0.685 0.315 0.000
T81.5 Foreign body accidentally left in body cavity or operation wound following a procedure
0.685 0.315 0.000
M25.3 Other instability of joint
0.684 0.316 0.000
M25.2 Flail joint
0.684 0.316 0.000
M25.1 Fistula of joint
0.684 0.316 0.000
M25.0 Haemarthrosis
0.684 0.316 0.000
A80-A89 Viral infections of the central nervous system
0.683 0.317 0.000
S52 Fracture of forearm
0.682 0.318 0.000
D35.2 Pituitary gland
0.682 0.318 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.682 0.318 0.000
I09 Other rheumatic heart diseases
0.682 0.318 0.000
I06 Rheumatic aortic valve diseases
0.682 0.318 0.000
G54 Nerve root and plexus disorders
0.682 0.318 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.682 0.318 0.000
G52 Disorders of other cranial nerves
0.682 0.318 0.000
M19.96 Arthrosis, unspecified-Lower leg
0.681 0.319 0.000
G20-G26 Extrapyramidal and movement disorders
0.681 0.319 0.000
D04 Carcinoma in situ of skin
0.680 0.320 0.000
T87.6 Other and unspecified complications of amputation stump
0.680 0.320 0.000
C68 Malignant neoplasm of other and unspecified urinary organs
0.679 0.321 0.000
C65 Malignant neoplasm of renal pelvis
0.679 0.321 0.000
Y43 Primarily systemic agents
0.679 0.321 0.000
M24.1 Other articular cartilage disorders
0.679 0.321 0.000
H33.5 Other retinal detachments
0.677 0.322 0.000
H33.4 Traction detachment of retina
0.677 0.322 0.000
H33.1 Retinoschisis and retinal cysts
0.677 0.322 0.000
I11 Hypertensive heart disease
0.677 0.323 0.000
G30-G32 Other degenerative diseases of the nervous system
0.677 0.323 0.000
D12.4 Descending colon
0.676 0.324 0.000
H35.9 Retinal disorder, unspecified
0.676 0.324 0.000
H35.6 Retinal haemorrhage
0.676 0.324 0.000
H35.2 Other proliferative retinopathy
0.676 0.324 0.000
H35.1 Retinopathy of prematurity
0.676 0.324 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.675 0.325 0.000
I15 Secondary hypertension
0.674 0.325 0.000
I13 Hypertensive heart and renal disease
0.674 0.325 0.000
C34.3 Lower lobe, bronchus or lung
0.674 0.325 0.000
H33.2 Serous retinal detachment
0.674 0.326 0.000
M77 Other enthesopathies
0.674 0.326 0.000
C34.9 Bronchus or lung, unspecified
0.673 0.327 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.673 0.327 0.000
M19.92 Arthrosis, unspecified (Upper arm)
0.670 0.330 0.000
D09 Carcinoma in situ of other and unspecified sites
0.670 0.330 0.000
M17.5 Other secondary gonarthrosis
0.668 0.332 0.000
M17.4 Other secondary gonarthrosis, bilateral
0.668 0.332 0.000
M17.2 Posttraumatic gonarthrosis, bilateral
0.668 0.332 0.000
G50.0 Trigeminal neuralgia
0.668 0.332 0.000
T82.3 Mechanical complication of other vascular grafts
0.667 0.333 0.000
C67.6 Ureteric orifice
0.666 0.334 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.666 0.334 0.000
C85.1 B-cell lymphoma, unspecified
0.665 0.335 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.665 0.335 0.000
G55.8 Nerve root and plexus compressions in other diseases classified elsewhere
0.665 0.335 0.000
G55.0 Nerve root and plexus compressions in neoplastic disease
0.665 0.335 0.000
C50.4 Upper-outer quadrant of breast
0.665 0.335 0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.664 0.336 0.000
G56 Mononeuropathies of upper limb
0.664 0.336 0.000
M21.2 Flexion deformity
0.664 0.336 0.000
M06 Other rheumatoid arthritis
0.663 0.337 0.000
I77.5 Necrosis of artery
0.663 0.337 0.000
I77.4 Coeliac artery compression syndrome
0.663 0.337 0.000
I77.3 Arterial fibromuscular dysplasia
0.663 0.337 0.000
I77.2 Rupture of artery
0.663 0.337 0.000
I77.0 Arteriovenous fistula, acquired
0.663 0.337 0.000
S90-S99 Injuries to the ankle and foot
0.663 0.337 0.000
M47 Spondylosis
0.663 0.337 0.000
I12 Hypertensive renal disease
0.662 0.338 0.000
M23.4 Loose body in knee
0.662 0.338 0.000
D14.0 Middle ear, nasal cavity and accessory sinuses
0.661 0.339 0.000
M25.96 Joint disorder, unspecified (Lower leg)
0.661 0.339 0.000
B99-B99 Other infectious diseases
0.660 0.339 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.660 0.339 0.000
B65-B83 Helminthiases
0.660 0.339 0.000
B50-B64 Protozoal diseases
0.660 0.339 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.660 0.339 0.000
B15-B19 Viral hepatitis
0.660 0.339 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.660 0.339 0.000
A75-A79 Rickettsioses
0.660 0.339 0.000
A70-A74 Other diseases caused by chlamydiae
0.660 0.339 0.000
A65-A69 Other spirochaetal diseases
0.660 0.339 0.000
A20-A28 Certain zoonotic bacterial diseases
0.660 0.339 0.000
A15-A19 Tuberculosis
0.660 0.339 0.000
B95.8 Unspecified staphylococcus as the cause of diseases classified to other chapters
0.660 0.340 0.000
I74.9 Embolism and thrombosis of unspecified artery
0.659 0.341 0.000
I74.8 Embolism and thrombosis of other arteries
0.659 0.341 0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.659 0.341 0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.659 0.341 0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.659 0.341 0.000
I74.0 Embolism and thrombosis of abdominal aorta
0.659 0.341 0.000
C43.5 Malignant melanoma of trunk
0.658 0.342 0.000
G61 Inflammatory polyneuropathy
0.657 0.343 0.000
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.657 0.343 0.000
M19.07 Primary arthrosis of other joints (Ankle and foot)
0.657 0.343 0.000
T66-T78 Other and unspecified effects of external causes
0.655 0.344 0.000
C77.1 Intrathoracic lymph nodes
0.656 0.344 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.655 0.345 0.000
H34.2 Other retinal artery occlusions
0.654 0.346 0.000
B35 Dermatophytosis
0.652 0.348 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.652 0.348 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.651 0.348 0.000
C95 Leukaemia of unspecified cell type
0.651 0.348 0.000
C94 Other leukaemias of specified cell type
0.651 0.348 0.000
C93 Monocytic leukaemia
0.651 0.348 0.000
C88 Malignant immunoproliferative diseases
0.651 0.348 0.000
C86 Other specified types of T/NK-cell lymphoma
0.651 0.348 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.651 0.348 0.000
C81 Hodgkin's disease
0.651 0.348 0.000
G55.3 Nerve root and plexus compressions in other dorsopathies
0.651 0.349 0.000
I44.7 Left bundle-branch block, unspecified
0.650 0.350 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.649 0.350 0.000
M23.9 Internal derangement of knee, unspecified
0.649 0.351 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.649 0.351 0.000
M23.5 Chronic instability of knee
0.649 0.351 0.000
M23.1 Discoid meniscus (congenital)
0.649 0.351 0.000
M23.0 Cystic meniscus
0.649 0.351 0.000
Q50-Q56 Congenital malformations of genital organs
0.649 0.351 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.649 0.351 0.000
C67.8 Overlapping lesion of bladder
0.648 0.352 0.000
C67.7 Urachus
0.648 0.352 0.000
C67.1 Dome of bladder
0.648 0.352 0.000
D13 Benign neoplasm of other and ill-defined parts of digestive system
0.647 0.352 0.000
C77.9 Lymph node, unspecified
0.647 0.353 0.000
M25.76 Osteophyte (Lower leg)
0.647 0.353 0.000
I08.9 Multiple valve disease, unspecified
0.647 0.353 0.000
I08.8 Other multiple valve diseases
0.647 0.353 0.000
I08.2 Disorders of both aortic and tricuspid valves
0.647 0.353 0.000
H50 Other strabismus
0.646 0.353 0.000
G55.2 Nerve root and plexus compressions in spondylosis
0.645 0.355 0.000
D33 Benign neoplasm of brain and other parts of central nervous system
0.645 0.355 0.000
C79.1 Secondary malignant neoplasm of bladder and other and unspecified urinary organs
0.645 0.355 0.000
H35.0 Background retinopathy and retinal vascular changes
0.644 0.355 0.000
M41 Scoliosis
0.644 0.356 0.000
I44.3 Other and unspecified atrioventricular block
0.644 0.356 0.000
D02 Carcinoma in situ of middle ear and respiratory system
0.643 0.357 0.000
D01 Carcinoma in situ of other and unspecified digestive organs
0.643 0.357 0.000
D00 Carcinoma in situ of oral cavity, oesophagus and stomach
0.643 0.357 0.000
D36 Benign neoplasm of other and unspecified sites
0.642 0.358 0.000
B37.8 Candidiasis of other sites
0.642 0.358 0.000
Q60-Q64 Congenital malformations of the urinary system
0.641 0.359 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.641 0.359 0.000
E20-E35 Disorders of other endocrine glands
0.641 0.359 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.641 0.359 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.641 0.359 0.000
C91 Lymphoid leukaemia
0.640 0.360 0.000
M16.6 Other secondary coxarthrosis, bilateral
0.640 0.360 0.000
M16.5 Other posttraumatic coxarthrosis
0.640 0.360 0.000
M16.4 Posttraumatic coxarthrosis, bilateral
0.640 0.360 0.000
M16.2 Coxarthrosis resulting from dysplasia, bilateral
0.640 0.360 0.000
D32 Benign neoplasm of meninges
0.639 0.360 0.000
I35.1 Aortic (valve) insufficiency
0.639 0.361 0.000
I33 Acute and subacute endocarditis
0.638 0.362 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.638 0.362 0.000
M17.9 Gonarthrosis, unspecified
0.638 0.362 0.000
M21.0 Valgus deformity, not elsewhere classified
0.638 0.362 0.000
I83.0 Varicose veins of lower extremities with ulcer
0.638 0.362 0.000
B95.5 Unspecified streptococcus as the cause of diseases classified to other chapters
0.636 0.364 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.636 0.364 0.000
C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs
0.634 0.366 0.000
C38 Malignant neoplasm of heart, mediastinum and pleura
0.634 0.366 0.000
C32 Malignant neoplasm of larynx
0.634 0.366 0.000
C31 Malignant neoplasm of accessory sinuses
0.634 0.366 0.000
C30 Malignant neoplasm of nasal cavity and middle ear
0.634 0.366 0.000
C37 Malignant neoplasm of thymus
0.634 0.366 0.000
C33 Malignant neoplasm of trachea
0.634 0.366 0.000
G59.0 Diabetic mononeuropathy
0.632 0.367 0.000
M25.79 Osteophyte (Site unspecified)
0.632 0.368 0.000
M25.73 Osteophyte (Forearm)
0.632 0.368 0.000
M25.72 Osteophyte (Upper arm)
0.632 0.368 0.000
M25.71 Osteophyte (Shoulder region)
0.632 0.368 0.000
M25.70 Osteophyte (Multiple sites)
0.632 0.368 0.000
C67.4 Posterior wall of bladder
0.632 0.368 0.000
J40-J47 Chronic lower respiratory diseases
0.632 0.368 0.000
M76 Enthesopathies of lower limb, excluding foot
0.631 0.369 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.631 0.369 0.000
I84.3 External thrombosed haemorrhoids
0.631 0.369 0.000
C79.6 Secondary malignant neoplasm of ovary
0.631 0.369 0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts
0.631 0.369 0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.630 0.369 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.630 0.370 0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts
0.630 0.370 0.000
M19.93 Arthrosis, unspecified (Forearm)
0.630 0.370 0.000
M21.3 Wrist or foot drop (acquired)
0.630 0.370 0.000
W20-W49 Exposure to inanimate mechanical forces
0.628 0.372 0.000
A46 Erysipelas
0.628 0.372 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.627 0.373 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.627 0.373 0.000
M19.09 Primary arthrosis of other joints (Site unspecified)
0.626 0.374 0.000
M24.41 Recurrent dislocation and subluxation of joint (Shoulder region)
0.626 0.374 0.000
I31.9 Disease of pericardium, unspecified
0.626 0.374 0.000
C43.7 Malignant melanoma of lower limb, including hip
0.624 0.376 0.000
C67.2 Lateral wall of bladder
0.623 0.377 0.000
C34.0 Main bronchus
0.623 0.377 0.000
B25-B34 Other viral diseases
0.622 0.378 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.622 0.378 0.000
M66 Spontaneous rupture of synovium and tendon
0.622 0.378 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.622 0.378 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.622 0.378 0.000
I05.0 Mitral stenosis
0.621 0.378 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.621 0.379 0.000
T81.8 Other complications of procedures, not elsewhere classified
0.619 0.381 0.000
M49 Spondylopathies in diseases classified elsewhere
0.618 0.382 0.000
C43.9 Malignant melanoma of skin, unspecified
0.618 0.382 0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.618 0.382 0.000
I34.8 Other nonrheumatic mitral valve disorders
0.618 0.382 0.000
I34.2 Nonrheumatic mitral (valve) stenosis
0.618 0.382 0.000
Y43.3 Other antineoplastic drugs
0.618 0.382 0.000
M21.1 Varus deformity, not elsewhere classified
0.617 0.383 0.000
M25.74 Osteophyte (Hand)
0.616 0.384 0.000
I51.6 Cardiovascular disease, unspecified
0.615 0.384 0.000
I51.5 Myocardial degeneration
0.615 0.384 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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