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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs434841
log Bayes Factor = 249.848
Chromosome 6   position 32,191,041  (GRCh37) Explore rs434841 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
E10.9 Without complications
1.000 0.000 0.000
E10.3 With ophthalmic complications
1.000 0.000 0.000
E10.1 With ketoacidosis
1.000 0.000 0.000
E16.2 Hypoglycaemia, unspecified
1.000 0.000 0.000
H36.0 Diabetic retinopathy
1.000 0.000 0.000
K90.0 Coeliac disease
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
E11 Non-insulin-dependent diabetes mellitus
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
L40 Psoriasis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
E14 Unspecified diabetes mellitus
1.000 0.000 0.000
L40.5 Arthropathic psoriasis
1.000 0.000 0.000
N17-N19 Renal failure
1.000 0.000 0.000
Chapter VII Diseases of the eye and adnexa
1.000 0.000 0.000
E16 Other disorders of pancreatic internal secretion
1.000 0.000 0.000
E20-E35 Disorders of other endocrine glands
1.000 0.000 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
1.000 0.000 0.000
D80-D89 Certain disorders involving the immune mechanism
1.000 0.000 0.000
N18 Chronic renal failure
1.000 0.000 0.000
E11.9 Without complications
1.000 0.000 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
1.000 0.000 0.000
H36 Retinal disorders in diseases classified elsewhere
1.000 0.000 0.000
H30-H36 Disorders of choroid and retina
1.000 0.000 0.000
E05.0 Thyrotoxicosis with diffuse goitre
1.000 0.000 0.000
D86 Sarcoidosis
1.000 0.000 0.000
E14.3 With ophthalmic complications
1.000 0.000 0.000
Chapter XIV Diseases of the genitourinary system
1.000 0.000 0.000
K90 Intestinal malabsorption
1.000 0.000 0.000
N18.9 Chronic renal failure, unspecified
0.999 0.001 0.000
N00-N08 Glomerular diseases
0.999 0.001 0.000
D60-D64 Aplastic and other anaemias
0.999 0.001 0.000
E11.3 With ophthalmic complications
0.999 0.001 0.000
D64 Other anaemias
0.999 0.001 0.000
D64.9 Anaemia, unspecified
0.999 0.001 0.000
E03 Other hypothyroidism
0.998 0.002 0.000
E10.4 With neurological complications
0.998 0.002 0.000
L40-L45 Papulosquamous disorders
0.998 0.002 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.997 0.003 0.000
E03.9 Hypothyroidism, unspecified
0.997 0.003 0.000
K70-K77 Diseases of liver
0.996 0.004 0.000
Chapter XI Diseases of the digestive system
0.995 0.005 0.000
D86.9 Sarcoidosis, unspecified
0.995 0.005 0.000
E27 Other disorders of adrenal gland
0.995 0.005 0.000
K90-K93 Other diseases of the digestive system
0.995 0.005 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.994 0.006 0.000
N04 Nephrotic syndrome
0.994 0.006 0.000
N17 Acute renal failure
0.993 0.007 0.000
K75 Other inflammatory liver diseases
0.992 0.008 0.000
Chapter II Neoplasms
0.992 0.008 0.000
E27.1 Primary adrenocortical insufficiency
0.991 0.009 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.989 0.011 0.000
K75.4 Autoimmune hepatitis
0.987 0.013 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.986 0.014 0.000
N17.9 Acute renal failure, unspecified
0.985 0.015 0.000
Q60-Q64 Congenital malformations of the urinary system
0.984 0.016 0.000
E11.1 With ketoacidosis
0.984 0.016 0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.983 0.017 0.000
N04.9 Unspecified
0.983 0.017 0.000
E10.2 With renal complications
0.980 0.020 0.000
C15-C26 Malignant neoplasms of digestive organs
0.979 0.021 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.978 0.022 0.000
E10.8 With unspecified complications
0.977 0.023 0.000
C18 Malignant neoplasm of colon
0.972 0.028 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.970 0.030 0.000
C18.7 Sigmoid colon
0.967 0.033 0.000
D50-D53 Nutritional anaemias
0.965 0.035 0.000
C91 Lymphoid leukaemia
0.965 0.035 0.000
K74 Fibrosis and cirrhosis of liver
0.964 0.036 0.000
K90.9 Intestinal malabsorption, unspecified
0.964 0.036 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.958 0.042 0.000
C02 Malignant neoplasm of other and unspecified parts of tongue
0.957 0.043 0.000
D86.8 Sarcoidosis of other and combined sites
0.953 0.047 0.000
N18.0 End-stage renal disease
0.952 0.048 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.949 0.051 0.000
K75.8 Other specified inflammatory liver diseases
0.949 0.051 0.000
C04 Malignant neoplasm of floor of mouth
0.947 0.053 0.000
K74.6 Other and unspecified cirrhosis of liver
0.945 0.055 0.000
D50 Iron deficiency anaemia
0.942 0.058 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.937 0.063 0.000
N08 Glomerular disorders in diseases classified elsewhere
0.935 0.065 0.000
C91.1 Chronic lymphocytic leukaemia
0.935 0.065 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.932 0.068 0.000
L10-L14 Bullous disorders
0.931 0.068 0.000
E10.5 With peripheral circulatory complications
0.931 0.069 0.000
H50 Other strabismus
0.931 0.069 0.000
H53-H54 Visual disturbances and blindness
0.931 0.069 0.000
K72 Hepatic failure, not elsewhere classified
0.924 0.076 0.000
D50.9 Iron deficiency anaemia, unspecified
0.924 0.076 0.000
Q43 Other congenital malformations of intestine
0.922 0.078 0.000
C18.9 Colon, unspecified
0.920 0.080 0.000
C84.5 Other and unspecified T-cell lymphomas
0.919 0.081 0.000
Q61 Cystic kidney disease
0.919 0.081 0.000
E10.0 With coma
0.917 0.083 0.000
C02.1 Border of tongue
0.914 0.086 0.000
N05 Unspecified nephritic syndrome
0.913 0.087 0.000
C04.9 Floor of mouth, unspecified
0.911 0.089 0.000
H50.0 Convergent concomitant strabismus
0.911 0.089 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.910 0.090 0.000
C20 Malignant neoplasm of rectum
0.909 0.091 0.000
E21.3 Hyperparathyroidism, unspecified
0.909 0.091 0.000
D86.3 Sarcoidosis of skin
0.908 0.092 0.000
H30 Chorioretinal inflammation
0.907 0.092 0.000
H46 Optic neuritis
0.902 0.098 0.000
L13 Other bullous disorders
0.900 0.100 0.000
E24 Cushing's syndrome
0.899 0.101 0.000
Q60 Renal agenesis and other reduction defects of kidney
0.897 0.103 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.896 0.104 0.000
K72.9 Hepatic failure, unspecified
0.887 0.113 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.884 0.116 0.000
E14.9 Without complications
0.882 0.118 0.000
Q43.9 Congenital malformation of intestine, unspecified
0.882 0.118 0.000
E14.8 With unspecified complications
0.882 0.118 0.000
N08.3 Glomerular disorders in diabetes mellitus
0.881 0.119 0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver
0.880 0.120 0.000
L13.0 Dermatitis herpetiformis
0.878 0.122 0.000
C02.9 Tongue, unspecified
0.875 0.125 0.000
K73 Chronic hepatitis, not elsewhere classified
0.874 0.125 0.000
E27.8 Other specified disorders of adrenal gland
0.873 0.127 0.000
E06 Thyroiditis
0.873 0.127 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.871 0.129 0.000
H34 Retinal vascular occlusions
0.865 0.135 0.000
N18.4 Chronic kidney disease, stage 4
0.864 0.136 0.000
E23 Hypofunction and other disorders of pituitary gland
0.863 0.137 0.000
D55-D59 Haemolytic anaemias
0.859 0.141 0.000
E14.1 With ketoacidosis
0.856 0.144 0.000
C88 Malignant immunoproliferative diseases
0.856 0.144 0.000
Q80-Q89 Other congenital malformations
0.855 0.145 0.000
L40.0 Psoriasis vulgaris
0.849 0.151 0.000
N04.2 Diffuse membranous glomerulonephritis
0.848 0.152 0.000
D64.8 Other specified anaemias
0.841 0.159 0.000
E50-E64 Other nutritional deficiencies
0.838 0.162 0.000
N17.0 Acute renal failure with tubular necrosis
0.837 0.163 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.836 0.164 0.000
E10.7 With multiple complications
0.835 0.164 0.000
H55-H59 Other disorders of eye and adnexa
0.832 0.168 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.832 0.168 0.000
N05.2 Diffuse membranous glomerulonephritis
0.832 0.168 0.000
C85.1 B-cell lymphoma, unspecified
0.831 0.169 0.000
E40-E46 Malnutrition
0.829 0.171 0.000
H54 Blindness and low vision
0.829 0.171 0.000
D80 Immunodeficiency with predominantly antibody defects
0.829 0.171 0.000
C95 Leukaemia of unspecified cell type
0.827 0.173 0.000
E10.6 With other specified complications
0.827 0.173 0.000
H30.9 Chorioretinal inflammation, unspecified
0.827 0.173 0.000
E07 Other disorders of thyroid
0.826 0.174 0.000
D50.8 Other iron deficiency anaemias
0.825 0.175 0.000
C08 Malignant neoplasm of other and unspecified major salivary glands
0.818 0.182 0.000
C81 Hodgkin's disease
0.815 0.185 0.000
E21.0 Primary hyperparathyroidism
0.811 0.189 0.000
E11.7 With multiple complications
0.811 0.189 0.000
E14.5 With peripheral circulatory complications
0.811 0.189 0.000
H50.5 Heterophoria
0.810 0.190 0.000
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified
0.808 0.192 0.000
N18.3 Chronic kidney disease, stage 3
0.806 0.194 0.000
H49 Paralytic strabismus
0.806 0.194 0.000
E06.3 Autoimmune thyroiditis
0.806 0.194 0.000
N04.1 Focal and segmental glomerular lesions
0.804 0.196 0.000
H53 Visual disturbances
0.803 0.197 0.000
C17 Malignant neoplasm of small intestine
0.802 0.198 0.000
K73.2 Chronic active hepatitis, not elsewhere classified
0.800 0.200 0.000
C18.0 Caecum
0.799 0.201 0.000
C91.9 Lymphoid leukaemia, unspecified
0.798 0.202 0.000
Q61.2 Polycystic kidney, adult type
0.796 0.204 0.000
C92 Myeloid leukaemia
0.794 0.206 0.000
N25-N29 Other disorders of kidney and ureter
0.794 0.206 0.000
D68 Other coagulation defects
0.793 0.207 0.000
D86.1 Sarcoidosis of lymph nodes
0.791 0.209 0.000
H50.3 Intermittent heterotropia
0.790 0.210 0.000
K71 Toxic liver disease
0.789 0.211 0.000
Q64 Other congenital malformations of urinary system
0.786 0.214 0.000
E21.2 Other hyperparathyroidism
0.783 0.217 0.000
Q60.2 Renal agenesis, unspecified
0.782 0.218 0.000
E70-E90 Metabolic disorders
0.782 0.218 0.000
N05.1 Focal and segmental glomerular lesions
0.779 0.221 0.000
E07.8 Other specified disorders of thyroid
0.778 0.222 0.000
C07 Malignant neoplasm of parotid gland
0.778 0.222 0.000
E23.7 Disorder of pituitary gland, unspecified
0.776 0.224 0.000
H55 Nystagmus and other irregular eye movements
0.773 0.227 0.000
K74.5 Biliary cirrhosis, unspecified
0.772 0.228 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.771 0.229 0.000
E53 Deficiency of other B group vitamins
0.771 0.229 0.000
E14.2 Withrenal complications
0.766 0.234 0.000
E11.5 With peripheral circulatory complications
0.765 0.235 0.000
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
0.765 0.235 0.000
C09 Malignant neoplasm of tonsil
0.763 0.237 0.000
Q00-Q07 Congenital malformations of the nervous system
0.760 0.240 0.000
E29 Testicular dysfunction
0.760 0.240 0.000
Q60.0 Renal agenesis, unilateral
0.760 0.240 0.000
Q67 Congenital musculoskeletal deformities of head, face, spine and chest
0.758 0.242 0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.757 0.243 0.000
Q44.6 Cystic disease of liver
0.755 0.245 0.000
H34.8 Other retinal vascular occlusions
0.754 0.246 0.000
D73 Diseases of spleen
0.753 0.247 0.000
Q63 Other congenital malformations of kidney
0.753 0.247 0.000
E31 Polyglandular dysfunction
0.752 0.248 0.000
H43-H45 Disorders of vitreous body and globe
0.750 0.250 0.000
E24.0 Pituitary-dependent Cushing's disease
0.750 0.250 0.000
Q75 Other congenital malformations of skull and face bones
0.750 0.250 0.000
Q61.3 Polycystic kidney, unspecified
0.749 0.251 0.000
Q43.8 Other specified congenital malformations of intestine
0.749 0.251 0.000
Q76 Congenital malformations of spine and bony thorax
0.747 0.253 0.000
E24.2 Drug-induced Cushing's syndrome
0.747 0.253 0.000
E11.2 With renal complications
0.747 0.253 0.000
L40.3 Pustulosis palmaris et plantaris
0.746 0.254 0.000
E25 Adrenogenital disorders
0.746 0.254 0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.746 0.254 0.000
C18.1 Appendix
0.744 0.256 0.000
E34 Other endocrine disorders
0.741 0.259 0.000
C84.8 Cutaneous T-cell lymphoma, unspecified
0.741 0.259 0.000
C04.0 Anterior floor of mouth
0.741 0.259 0.000
C91.4 Hairy-cell leukaemia
0.740 0.260 0.000
D62 Acute posthaemorrhagic anaemia
0.740 0.260 0.000
H54.0 Blindness, both eyes
0.740 0.260 0.000
E22 Hyperfunction of pituitary gland
0.740 0.260 0.000
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.737 0.263 0.000
E28 Ovarian dysfunction
0.735 0.265 0.000
L50-L54 Urticaria and erythema
0.734 0.266 0.000
L40.1 Generalised pustular psoriasis
0.733 0.267 0.000
N18.2 Chronic kidney disease, stage 2
0.733 0.267 0.000
Q61.9 Cystic kidney disease, unspecified
0.732 0.268 0.000
E27.9 Disorder of adrenal gland, unspecified
0.732 0.268 0.000
Q40 Other congenital malformations of upper alimentary tract
0.731 0.269 0.000
Q39 Congenital malformations of oesophagus
0.731 0.269 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.731 0.269 0.000
D52 Folate deficiency anaemia
0.730 0.270 0.000
N05.8 Other
0.729 0.271 0.000
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter
0.728 0.272 0.000
E16.1 Other hypoglycaemia
0.728 0.272 0.000
C00 Malignant neoplasm of lip
0.728 0.272 0.000
N08.5 Glomerular disorders in systemic connective tissue disorders
0.728 0.272 0.000
D51 Vitamin B12 deficiency anaemia
0.727 0.273 0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.726 0.274 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.724 0.276 0.000
D72 Other disorders of white blood cells
0.724 0.276 0.000
Q61.5 Medullary cystic kidney
0.723 0.277 0.000
C84.0 Mycosis fungoides
0.723 0.277 0.000
N04.0 Minor glomerular abnormality
0.722 0.277 0.000
D89.9 Disorder involving the immune mechanism, unspecified
0.722 0.278 0.000
Q38 Other congenital malformations of tongue, mouth and pharynx
0.722 0.278 0.000
C06 Malignant neoplasm of other and unspecified parts of mouth
0.721 0.279 0.000
N02 Recurrent and persistent haematuria
0.721 0.279 0.000
Q85 Phakomatoses, not elsewhere classified
0.720 0.280 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.719 0.281 0.000
H54.9 Unspecified visual impairment (binocular)
0.719 0.281 0.000
C03 Malignant neoplasm of gum
0.718 0.282 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.718 0.282 0.000
D82 Immunodeficiency associated with other major defects
0.718 0.282 0.000
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.717 0.283 0.000
L40.2 Acrodermatitis continua
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
E14.7 With multiple complications
0.717 0.283 0.000
E14.0 With coma
0.717 0.283 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.717 0.283 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.717 0.283 0.000
E16.4 Abnormal secretion of gastrin
0.717 0.283 0.000
E16.3 Increased secretion of glucagon
0.717 0.283 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.717 0.283 0.000
E32 Diseases of thymus
0.717 0.283 0.000
E30 Disorders of puberty, not elsewhere classified
0.717 0.283 0.000
E15 Nondiabetic hypoglycaemic coma
0.717 0.283 0.000
D81 Combined immunodeficiencies
0.717 0.283 0.000
H36.8 Other retinal disorders in diseases classified elsewhere
0.717 0.283 0.000
C12 Malignant neoplasm of pyriform sinus
0.717 0.283 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.717 0.283 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.717 0.283 0.000
K90.3 Pancreatic steatorrhoea
0.717 0.283 0.000
K90.2 Blind loop syndrome, not elsewhere classified
0.717 0.283 0.000
K90.1 Tropical sprue
0.717 0.283 0.000
N07 Hereditary nephropathy, not elsewhere classified
0.716 0.284 0.000
N06 Isolated proteinuria with specified morphological lesion
0.716 0.284 0.000
N01 Rapidly progressive nephritic syndrome
0.716 0.284 0.000
N00 Acute nephritic syndrome
0.716 0.284 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.716 0.284 0.000
D64.4 Congenital dyserythropoietic anaemia
0.716 0.284 0.000
D64.3 Other sideroblastic anaemias
0.716 0.284 0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.716 0.284 0.000
D64.1 Secondary sideroblastic anaemia due to disease
0.716 0.284 0.000
D64.0 Hereditary sideroblastic anaemia
0.716 0.284 0.000
E14.6 With other specified complications
0.716 0.284 0.000
E03.5 Myxoedema coma
0.716 0.284 0.000
E03.4 Atrophy of thyroid (acquired)
0.716 0.284 0.000
E03.3 Postinfectious hypothyroidism
0.716 0.284 0.000
E53.8 Deficiency of other specified B group vitamins
0.715 0.285 0.000
L44 Other papulosquamous disorders
0.715 0.285 0.000
L41 Parapsoriasis
0.715 0.285 0.000
L45 Papulosquamous disorders in diseases classified elsewhere
0.715 0.285 0.000
C11 Malignant neoplasm of nasopharynx
0.715 0.285 0.000
K77 Liver disorders in diseases classified elsewhere
0.714 0.286 0.000
D84 Other immunodeficiencies
0.714 0.286 0.000
E27.5 Adrenomedullary hyperfunction
0.713 0.287 0.000
E27.0 Other adrenocortical overactivity
0.713 0.287 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.713 0.287 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.713 0.287 0.000
C94 Other leukaemias of specified cell type
0.713 0.287 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.713 0.287 0.000
H53.8 Other visual disturbances
0.713 0.287 0.000
H50.4 Other and unspecified heterotropia
0.713 0.287 0.000
N04.8 Other
0.713 0.287 0.000
N04.7 Diffuse crescentic glomerulonephritis
0.713 0.287 0.000
N04.6 Dense deposit disease
0.713 0.287 0.000
N04.5 Diffuse mesangiocapillary glomerulonephritis
0.713 0.287 0.000
N04.4 Diffuse endocapillary proliferative glomerulonephritis
0.713 0.287 0.000
N04.3 Diffuse mesangial proliferative glomerulonephritis
0.713 0.287 0.000
E21.4 Other specified disorders of parathyroid gland
0.712 0.288 0.000
N17.2 Acute renal failure with medullary necrosis
0.712 0.288 0.000
N17.1 Acute renal failure with acute cortical necrosis
0.712 0.288 0.000
D86.0 Sarcoidosis of lung
0.712 0.288 0.000
K75.2 Nonspecific reactive hepatitis
0.711 0.289 0.000
K75.1 Phlebitis of portal vein
0.711 0.289 0.000
D59 Acquired haemolytic anaemia
0.710 0.290 0.000
N25 Disorders resulting from impaired renal tubular function
0.710 0.290 0.000
D50.1 Sideropenic dysphagia
0.709 0.291 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.709 0.291 0.000
C85.0 Lymphosarcoma
0.709 0.291 0.000
N10-N16 Renal tubulo-interstitial diseases
0.709 0.291 0.000
E20 Hypoparathyroidism
0.709 0.291 0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.709 0.291 0.000
D69 Purpura and other haemorrhagic conditions
0.708 0.292 0.000
Q35-Q37 Cleft lip and cleft palate
0.707 0.292 0.000
E46 Unspecified protein-energy malnutrition
0.707 0.293 0.000
C13 Malignant neoplasm of hypopharynx
0.705 0.295 0.000
Q70 Syndactyly
0.705 0.295 0.000
D58 Other hereditary haemolytic anaemias
0.704 0.296 0.000
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.000 0.298 0.702
N05.5 Diffuse mesangiocapillary glomerulonephritis
0.701 0.299 0.000
Q42 Congenital absence, atresia and stenosis of large intestine
0.701 0.299 0.000
Q41 Congenital absence, atresia and stenosis of small intestine
0.701 0.299 0.000
E03.8 Other specified hypothyroidism
0.701 0.299 0.000
Q44.7 Other congenital malformations of liver
0.700 0.300 0.000
L40.4 Guttate psoriasis
0.699 0.301 0.000
K72.1 Chronic hepatic failure
0.699 0.301 0.000
H30.2 Posterior cyclitis
0.698 0.302 0.000
E11.8 With unspecified complications
0.698 0.302 0.000
K74.0 Hepatic fibrosis
0.696 0.304 0.000
E13 Other specified diabetes mellitus
0.696 0.304 0.000
Q43.1 Hirschsprung's disease
0.695 0.305 0.000
E24.9 Cushing's syndrome, unspecified
0.693 0.307 0.000
C84.4 Peripheral T-cell lymphoma
0.692 0.308 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.692 0.308 0.000
C91.8 Mature B-cell leukaemia Burkitt-type
0.692 0.308 0.000
C91.7 Other lymphoid leukaemia
0.692 0.308 0.000
C91.6 Prolymphocytic leukaemia of T-cell type
0.692 0.308 0.000
C91.5 Adult T-cell leukaemia
0.692 0.308 0.000
C91.3 Prolymphocytic leukaemia
0.692 0.308 0.000
C91.2 Subacute lymphocytic leukaemia
0.692 0.308 0.000
K74.4 Secondary biliary cirrhosis
0.691 0.309 0.000
K74.2 Hepatic fibrosis with hepatic sclerosis
0.691 0.309 0.000
K74.1 Hepatic sclerosis
0.691 0.309 0.000
N02.2 Diffuse membranous glomerulonephritis
0.691 0.309 0.000
C08.0 Submandibular gland
0.691 0.309 0.000
E88 Other metabolic disorders
0.689 0.311 0.000
H53.1 Subjective visual disturbances
0.689 0.311 0.000
Q44.5 Other congenital malformations of bile ducts
0.688 0.312 0.000
C84.9 Mature T/NK-cell lymphoma, unspecified
0.687 0.313 0.000
C84.7 Anaplastic large cell lymphoma, ALK-negative
0.687 0.313 0.000
C84.6 Anaplastic large cell lymphoma, ALK-positive
0.687 0.313 0.000
C84.3 Lymphoepithelioid lymphoma
0.687 0.313 0.000
C84.2 T-zone lymphoma
0.687 0.313 0.000
C84.1 Sezary's diease
0.687 0.313 0.000
C02.8 Overlapping lesion of tongue
0.686 0.314 0.000
C02.3 Anterior two-thirds of tongue, part unspecified
0.686 0.314 0.000
C02.0 Dorsal surface of tongue
0.686 0.314 0.000
Q45 Other congenital malformations of digestive system
0.686 0.314 0.000
E14.4 With neurological complications
0.685 0.315 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.685 0.315 0.000
D83 Common variable immunodeficiency
0.683 0.317 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.681 0.319 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.680 0.320 0.000
C04.8 Overlapping lesion of floor of mouth
0.679 0.321 0.000
C04.1 Lateral floor of mouth
0.679 0.321 0.000
E23.6 Other disorders of pituitary gland
0.679 0.321 0.000
H49.1 Fourth [trochlear] nerve palsy
0.676 0.324 0.000
Q68 Other congenital musculoskeletal deformities
0.674 0.325 0.000
H50.8 Other specified strabismus
0.674 0.326 0.000
C95.9 Leukaemia, unspecified
0.673 0.327 0.000
N17.8 Other acute renal failure
0.672 0.328 0.000
D68.6 Other Thrombophilia
0.672 0.328 0.000
D80.1 Nonfamilial hypogammaglobulinaemia
0.672 0.328 0.000
H48 Disorders of optic [2nd] nerve and visual pathways in diseases classified elsewhere
0.672 0.328 0.000
K90.8 Other intestinal malabsorption
0.671 0.329 0.000
C17.1 Jejunum
0.671 0.329 0.000
N08.8 Glomerular disorders in other diseases classified elsewhere
0.671 0.329 0.000
N08.2 Glomerular disorders in blood diseases and disorders involving the immune mechanism
0.671 0.329 0.000
N08.1 Glomerular disorders in neoplastic diseases
0.671 0.329 0.000
N08.0 Glomerular disorders in infectious and parasitic diseases classified elsewhere
0.671 0.329 0.000
D70 Agranulocytosis
0.669 0.331 0.000
Q77 Osteochondrodysplasia with defects of growth of tubular bones and spine
0.668 0.332 0.000
Q73 Reduction defects of unspecified limb
0.668 0.332 0.000
Q72 Reduction defects of lower limb
0.668 0.332 0.000
Q71 Reduction defects of upper limb
0.668 0.332 0.000
Q69 Polydactyly
0.668 0.332 0.000
Q89 Other congenital malformations, not elsewhere classified
0.668 0.332 0.000
L10 Pemphigus
0.668 0.332 0.000
L14 Bullous disorders in diseases classified elsewhere
0.668 0.332 0.000
H50.6 Mechanical strabismus
0.668 0.332 0.000
E03.1 Congenital hypothyroidism without goitre
0.666 0.333 0.000
H50.2 Vertical strabismus
0.666 0.334 0.000
C90 Multiple myeloma and malignant plasma cell neoplasms
0.665 0.335 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.664 0.336 0.000
H49.4 Progressive external ophthalmoplegia
0.663 0.337 0.000
C86 Other specified types of T/NK-cell lymphoma
0.663 0.337 0.000
Q79.0 Congenital diaphragmatic hernia
0.662 0.338 0.000
D73.5 Infarction of spleen
0.662 0.338 0.000
Q65 Congenital deformities of hip
0.662 0.338 0.000
H58 Other disorders of eye and adnexa in diseases classified elsewhere
0.662 0.338 0.000
H43 Disorders of vitreous body
0.662 0.338 0.000
E89.0 Postprocedural hypothyroidism
0.661 0.339 0.000
Q43.7 Persistent cloaca
0.661 0.339 0.000
Q43.6 Congenital fistula of rectum and anus
0.661 0.339 0.000
Q43.5 Ectopic anus
0.661 0.339 0.000
Q43.4 Duplication of intestine
0.661 0.339 0.000
Q43.2 Other congenital functional disorders of colon
0.661 0.339 0.000
D68.5 Primary Thrombophilia
0.660 0.340 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.660 0.340 0.000
Q61.8 Other cystic kidney diseases
0.659 0.341 0.000
Q61.4 Renal dysplasia
0.659 0.341 0.000
Q61.1 Polycystic kidney, infantile type
0.659 0.341 0.000
N11 Chronic tubulo-interstitial nephritis
0.658 0.342 0.000
N05.6 Dense deposit disease
0.655 0.345 0.000
N05.4 Diffuse endocapillary proliferative glomerulonephritis
0.655 0.345 0.000
N05.3 Diffuse mesangial proliferative glomerulonephritis
0.655 0.345 0.000
N05.0 Minor glomerular abnormality
0.655 0.345 0.000
N08.4 Glomerular disorders in other endocrine, nutritional and metabolic diseases
0.653 0.347 0.000
C23 Malignant neoplasm of gallbladder
0.653 0.347 0.000
C25 Malignant neoplasm of pancreas
0.653 0.347 0.000
Q50-Q56 Congenital malformations of genital organs
0.653 0.347 0.000
H53.5 Colour vision deficiencies
0.652 0.348 0.000
H30.8 Other chorioretinal inflammations
0.651 0.349 0.000
H30.1 Disseminated chorioretinal inflammation
0.651 0.349 0.000
H30.0 Focal chorioretinal inflammation
0.651 0.349 0.000
E27.2 Addisonian crisis
0.650 0.350 0.000
E51 Thiamine deficiency
0.650 0.350 0.000
Q66 Congenital deformities of feet
0.650 0.350 0.000
N03 Chronic nephritic syndrome
0.648 0.352 0.000
E86 Volume depletion
0.647 0.353 0.000
Q74 Other congenital malformations of limb(s)
0.647 0.353 0.000
K71.9 Toxic liver disease, unspecified
0.647 0.353 0.000
Q67.5 Congenital deformity of spine
0.646 0.353 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.646 0.354 0.000
L40.8 Other psoriasis
0.645 0.354 0.000
L13.9 Bullous disorder, unspecified
0.645 0.354 0.000
L13.8 Other specified bullous disorders
0.645 0.354 0.000
L13.1 Subcorneal pustular dermatitis
0.645 0.354 0.000
Q64.7 Other congenital malformations of bladder and urethra
0.645 0.354 0.000
K76 Other diseases of liver
0.645 0.355 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.645 0.355 0.000
E24.8 Other Cushing's syndrome
0.645 0.355 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.645 0.355 0.000
E24.3 Ectopic ACTH syndrome
0.645 0.355 0.000
E24.1 Nelson's syndrome
0.645 0.355 0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.644 0.355 0.000
C18.8 Overlapping lesion of colon
0.644 0.356 0.000
D89.0 Polyclonal hypergammaglobulinaemia
0.644 0.356 0.000
Q60.6 Potter's syndrome
0.643 0.356 0.000
Q60.5 Renal hypoplasia, unspecified
0.643 0.356 0.000
Q60.4 Renal hypoplasia, bilateral
0.643 0.356 0.000
Q60.3 Renal hypoplasia, unilateral
0.643 0.356 0.000
Q60.1 Renal agenesis, bilateral
0.643 0.356 0.000
Q83 Congenital malformations of breast
0.643 0.357 0.000
H54.2 Low vision, both eyes
0.643 0.357 0.000
D74 Methaemoglobinaemia
0.642 0.358 0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.642 0.358 0.000
D71 Functional disorders of polymorphonuclear neutrophils
0.642 0.358 0.000
C81.0 Lymphocytic predominance
0.641 0.359 0.000
D68.4 Acquired coagulation factor deficiency
0.641 0.359 0.000
H34.1 Central retinal artery occlusion
0.641 0.359 0.000
Q82 Other congenital malformations of skin
0.640 0.360 0.000
Q63.8 Other specified congenital malformations of kidney
0.639 0.361 0.000
G56.0 Carpal tunnel syndrome
0.637 0.363 0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.637 0.363 0.000
Q43.3 Congenital malformations of intestinal fixation
0.636 0.364 0.000
Q79.8 Other congenital malformations of musculoskeletal system
0.636 0.364 0.000
C05 Malignant neoplasm of palate
0.636 0.364 0.000
D89.1 Cryoglobulinaemia
0.635 0.365 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.635 0.365 0.000
N18.1 Chronic kidney disease, stage 1
0.634 0.366 0.000
D67 Hereditary factor IX deficiency
0.634 0.366 0.000
Q61.0 Congenital single renal cyst
0.634 0.366 0.000
E05.8 Other thyrotoxicosis
0.633 0.366 0.000
G56 Mononeuropathies of upper limb
0.632 0.368 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.632 0.368 0.000
Q44.4 Choledochal cyst
0.631 0.369 0.000
Q44.3 Congenital stenosis and stricture of bile ducts
0.631 0.369 0.000
Q44.2 Atresia of bile ducts
0.631 0.369 0.000
Q44.1 Other congenital malformations of gallbladder
0.631 0.369 0.000
Q44.0 Agenesis, aplasia and hypoplasia of gallbladder
0.631 0.369 0.000
C81.1 Nodular sclerosis
0.630 0.370 0.000
E34.8 Other specified endocrine disorders
0.630 0.370 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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