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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs4389167
log Bayes Factor = 5.82795
Chromosome 16   position 74,592,132  (GRCh37) Explore rs4389167 on Ensembl!
Variant rs4389167 is part of Cluster X0278

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
0.999 0.001 0.000
M45-M49 Spondylopathies
0.997 0.003 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.997 0.003 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.996 0.004 0.000
E11 Non-insulin-dependent diabetes mellitus
0.995 0.005 0.000
Chapter XX External causes of morbidity and mortality
0.994 0.006 0.000
# Top node
0.994 0.006 0.000
E10.9 Without complications
0.992 0.008 0.000
E11.3 With ophthalmic complications
0.990 0.010 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.985 0.015 0.000
M50-M54 Other dorsopathies
0.985 0.015 0.000
M40-M43 Deforming dorsopathies
0.984 0.016 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.981 0.019 0.000
C91 Lymphoid leukaemia
0.978 0.022 0.000
M47 Spondylosis
0.973 0.027 0.000
Chapter VII Diseases of the eye and adnexa
0.971 0.029 0.000
C83.3 Large cell (diffuse)
0.968 0.032 0.000
C91.1 Chronic lymphocytic leukaemia
0.967 0.033 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.963 0.037 0.000
Y43 Primarily systemic agents
0.962 0.038 0.000
M54 Dorsalgia
0.958 0.042 0.000
M86-M90 Other osteopathies
0.956 0.044 0.000
Chapter II Neoplasms
0.949 0.051 0.000
M80-M85 Disorders of bone density and structure
0.948 0.052 0.000
H30-H36 Disorders of choroid and retina
0.942 0.058 0.000
H36.0 Diabetic retinopathy
0.941 0.059 0.000
H36 Retinal disorders in diseases classified elsewhere
0.941 0.059 0.000
M47.9 Spondylosis, unspecified
0.934 0.066 0.000
M54.5 Low back pain
0.925 0.075 0.000
E14 Unspecified diabetes mellitus
0.924 0.076 0.000
Y43.3 Other antineoplastic drugs
0.924 0.076 0.000
M81 Osteoporosis without pathological fracture
0.919 0.081 0.000
M43 Other deforming dorsopathies
0.917 0.083 0.000
E10.4 With neurological complications
0.916 0.084 0.000
Y45.0 Opioids and related analgesics
0.906 0.094 0.000
M46 Other inflammatory spondylopathies
0.902 0.098 0.000
M86 Osteomyelitis
0.901 0.099 0.000
M48 Other spondylopathies
0.900 0.100 0.000
M81.9 Osteoporosis, unspecified
0.899 0.101 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.896 0.104 0.000
M47.96 Spondylosis, unspecified (Lumbar region)
0.895 0.105 0.000
E10.3 With ophthalmic complications
0.893 0.107 0.000
M41 Scoliosis
0.892 0.108 0.000
M51 Other intervertebral disk disorders
0.891 0.109 0.000
M81.99 Osteoporosis, unspecified (Site unspecified)
0.888 0.112 0.000
Y45.1 Salicylates
0.888 0.112 0.000
H10-H13 Disorders of conjunctiva
0.884 0.116 0.000
C64-C68 Malignant neoplasms of urinary tract
0.882 0.118 0.000
C83.0 Small cell (diffuse)
0.880 0.120 0.000
H53-H54 Visual disturbances and blindness
0.879 0.121 0.000
C92 Myeloid leukaemia
0.879 0.121 0.000
M54.59 Low back pain (Site unspecified)
0.879 0.121 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.874 0.126 0.000
M47.90 Spondylosis, unspecified (Multiple sites in spine)
0.871 0.129 0.000
X60-X84 Intentional self-harm
0.866 0.134 0.000
V20-V29 Motorcycle rider injured in transport accident
0.864 0.136 0.000
M54.9 Dorsalgia, unspecified
0.864 0.136 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.864 0.136 0.000
E11.9 Without complications
0.863 0.137 0.000
M86.9 Osteomyelitis, unspecified
0.863 0.137 0.000
M85 Other disorders of bone density and structure
0.859 0.141 0.000
M43.1 Spondylolisthesis
0.858 0.142 0.000
Y57 Other and unspecified drugs and medicaments
0.852 0.148 0.000
E11.4 With neurological complications
0.848 0.152 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.848 0.152 0.000
M40 Kyphosis and lordosis
0.848 0.152 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.846 0.154 0.000
E10.6 With other specified complications
0.842 0.158 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.841 0.159 0.000
M53 Other dorsopathies, not elsewhere classified
0.840 0.160 0.000
C91.4 Hairy-cell leukaemia
0.831 0.169 0.000
M54.1 Radiculopathy
0.824 0.176 0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified
0.823 0.177 0.000
M41.9 Scoliosis, unspecified
0.822 0.178 0.000
M47.2 Other spondylosis with radiculopathy
0.820 0.180 0.000
M54.58 Low back pain (Sacral and sacrococcygeal region)
0.819 0.181 0.000
V80-V89 Other land transport accidents
0.817 0.183 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.815 0.185 0.000
H11 Other disorders of conjunctiva
0.813 0.187 0.000
E10.0 With coma
0.811 0.189 0.000
Y43.0 Antiallergic and antiemetic drugs
0.810 0.190 0.000
M90 Osteopathies in diseases classified elsewhere
0.810 0.190 0.000
H54 Blindness and low vision
0.805 0.195 0.000
E11.1 With ketoacidosis
0.802 0.198 0.000
E14.3 With ophthalmic complications
0.802 0.198 0.000
C88 Malignant immunoproliferative diseases
0.801 0.199 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.801 0.199 0.000
E10.5 With peripheral circulatory complications
0.801 0.199 0.000
M46.9 Inflammatory spondylopathy, unspecified
0.797 0.203 0.000
M45 Ankylosing spondylitis
0.795 0.205 0.000
E50-E64 Other nutritional deficiencies
0.795 0.205 0.000
M54.57 Low back pain (Lumbosacral region)
0.795 0.205 0.000
M85.8 Other specified disorders of bone density and structure
0.790 0.210 0.000
M91-M94 Chondropathies
0.788 0.212 0.000
Chapter XXII Codes for special purposes
0.787 0.213 0.000
E16 Other disorders of pancreatic internal secretion
0.786 0.214 0.000
E14.4 With neurological complications
0.785 0.215 0.000
M65-M68 Disorders of synovium and tendon
0.784 0.216 0.000
M48.5 Collapsed vertebra, not elsewhere classified
0.780 0.220 0.000
C83.8 Other types of diffuse non-Hodgkin's lymphoma
0.780 0.220 0.000
M47.8 Other spondylosis
0.780 0.220 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.773 0.227 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.772 0.228 0.000
X63 Intentional self-poisoning by and exposure to other drugs acting on the autonomic nervous system
0.772 0.228 0.000
X10-X19 Contact with heat and hot substances
0.771 0.229 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.767 0.233 0.000
M87 Osteonecrosis
0.767 0.233 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.764 0.236 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.764 0.236 0.000
C66 Malignant neoplasm of ureter
0.761 0.239 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.760 0.240 0.000
Y00-Y09 Assault
0.759 0.241 0.000
H40-H42 Glaucoma
0.759 0.241 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.758 0.242 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.757 0.243 0.000
C92.1 Chronic myeloid leukaemia
0.753 0.246 0.000
M48.0 Spinal stenosis
0.753 0.247 0.000
M60-M63 Disorders of muscles
0.753 0.247 0.000
M51.2 Other specified intervertebral disk displacement
0.751 0.249 0.000
Y44 Agents primarily affecting blood constituents
0.750 0.250 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.750 0.250 0.000
V01-V09 Pedestrian injured in transport accident
0.748 0.252 0.000
M43.16 Spondylolisthesis (Lumbar region)
0.744 0.256 0.000
Y42.7 Androgens and anabolic congeners
0.743 0.257 0.000
C95 Leukaemia of unspecified cell type
0.743 0.257 0.000
C83.1 Small cleaved cell (diffuse)
0.742 0.258 0.000
M43.17 Spondylolisthesis (Lumbosacral region)
0.742 0.258 0.000
C91.9 Lymphoid leukaemia, unspecified
0.742 0.258 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.738 0.261 0.000
M46.4 Discitis, unspecified
0.738 0.262 0.000
V98-V99 Other and unspecified transport accidents
0.734 0.266 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.733 0.267 0.000
Y45.5 4-Aminophenol derivatives
0.732 0.268 0.000
M47.27 Other spondylosis with radiculopathy (Lumbosacral region)
0.730 0.270 0.000
Y43.1 Antineoplastic antimetabolites
0.730 0.270 0.000
M86.95 Osteomyelitis, unspecified (Pelvic region and thigh)
0.729 0.271 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.729 0.271 0.000
M54.6 Pain in thoracic spine
0.728 0.272 0.000
C92.0 Acute myeloid leukaemia
0.727 0.273 0.000
H18 Other disorders of cornea
0.727 0.273 0.000
Y40 Systemic antibiotics
0.725 0.275 0.000
E16.2 Hypoglycaemia, unspecified
0.724 0.276 0.000
M86.94 Osteomyelitis, unspecified (Hand)
0.724 0.276 0.000
X69 Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
0.724 0.276 0.000
C81 Hodgkin's disease
0.724 0.276 0.000
M48.07 Spinal stenosis (Lumbosacral region)
0.723 0.277 0.000
E65-E68 Obesity and other hyperalimentation
0.723 0.277 0.000
E61 Deficiency of other nutrient elements
0.722 0.278 0.000
E40-E46 Malnutrition
0.721 0.279 0.000
M49 Spondylopathies in diseases classified elsewhere
0.721 0.279 0.000
X20-X29 Contact with venomous animals and plants
0.721 0.279 0.000
M40.2 Other and unspecified kyphosis
0.720 0.279 0.000
H21 Other disorders of iris and ciliary body
0.720 0.280 0.000
C67 Malignant neoplasm of bladder
0.720 0.280 0.000
W50-W64 Exposure to animate mechanical forces
0.719 0.281 0.000
H54.7 Unspecified visual loss
0.718 0.282 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
E10.8 With unspecified complications
0.716 0.284 0.000
E10.7 With multiple complications
0.716 0.284 0.000
M51.0 Lumbar and other intervertebral disk disorders with myelopathy
0.715 0.285 0.000
H54.0 Blindness, both eyes
0.715 0.285 0.000
Y59 Other and unspecified vaccines and biological substances
0.714 0.285 0.000
Y58 Bacterial vaccines
0.714 0.285 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.714 0.285 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.714 0.285 0.000
M81.95 Osteoporosis, unspecified (Pelvic region and thigh)
0.715 0.285 0.000
E11.7 With multiple complications
0.714 0.286 0.000
M85.6 Other cyst of bone
0.713 0.287 0.000
Y35-Y36 Legal intervention and operations of war
0.713 0.287 0.000
Y10-Y34 Event of undetermined intent
0.713 0.287 0.000
X85-X99 Assault
0.713 0.287 0.000
X30-X39 Exposure to forces of nature
0.713 0.287 0.000
X00-X09 Exposure to smoke, fire and flames
0.713 0.287 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.713 0.287 0.000
W75-W84 Other accidental threats to breathing
0.713 0.287 0.000
W65-W74 Accidental drowning and submersion
0.713 0.287 0.000
V95-V97 Air and space transport accidents
0.713 0.287 0.000
V90-V94 Water transport accidents
0.713 0.287 0.000
V70-V79 Bus occupant injured in transport accident
0.713 0.287 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.713 0.287 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.713 0.287 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.713 0.287 0.000
M51.4 Schmorl's nodes
0.713 0.287 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.713 0.287 0.000
M48.54 Collapsed vertebra, not elsewhere classified (Thoracic region)
0.711 0.289 0.000
M53.3 Sacrococcygeal disorders, not elsewhere classified
0.711 0.289 0.000
H11.0 Pterygium
0.708 0.292 0.000
E14.9 Without complications
0.708 0.292 0.000
M51.9 Intervertebral disk disorder, unspecified
0.708 0.292 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.706 0.294 0.000
C94 Other leukaemias of specified cell type
0.706 0.294 0.000
C93 Monocytic leukaemia
0.706 0.294 0.000
C86 Other specified types of T/NK-cell lymphoma
0.706 0.294 0.000
M42 Spinal osteochondrosis
0.706 0.294 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.705 0.295 0.000
M43.0 Spondylolysis
0.705 0.295 0.000
X63.0 Home
0.705 0.295 0.000
Q50-Q56 Congenital malformations of genital organs
0.704 0.296 0.000
C83.7 Burkitt's tumour
0.703 0.297 0.000
C83.6 Undifferentiated (diffuse)
0.703 0.297 0.000
C83.5 Lymphoblastic (diffuse)
0.703 0.297 0.000
C83.4 Immunoblastic (diffuse)
0.703 0.297 0.000
C83.2 Mixed small and large cell (diffuse)
0.703 0.297 0.000
C90 Multiple myeloma and malignant plasma cell neoplasms
0.703 0.297 0.000
M00-M03 Infectious arthropathies
0.702 0.297 0.000
E10.2 With renal complications
0.701 0.299 0.000
C91.8 Mature B-cell leukaemia Burkitt-type
0.701 0.299 0.000
C91.7 Other lymphoid leukaemia
0.701 0.299 0.000
C91.6 Prolymphocytic leukaemia of T-cell type
0.701 0.299 0.000
C91.5 Adult T-cell leukaemia
0.701 0.299 0.000
C91.3 Prolymphocytic leukaemia
0.701 0.299 0.000
C91.2 Subacute lymphocytic leukaemia
0.701 0.299 0.000
H34 Retinal vascular occlusions
0.701 0.299 0.000
M86.96 Osteomyelitis, unspecified (Lower leg)
0.701 0.299 0.000
M86.97 Osteomyelitis, unspecified (Ankle and foot)
0.700 0.300 0.000
M41.96 Scoliosis, unspecified (Lumbar region)
0.699 0.301 0.000
V23 Motorcycle rider injured in collision with car, pick-up truck or van
0.698 0.302 0.000
M47.0 Anterior spinal and vertebral artery compression syndromes
0.698 0.302 0.000
M54.99 Dorsalgia, unspecified (Site unspecified)
0.698 0.302 0.000
X50-X57 Overexertion, travel and privation
0.696 0.304 0.000
M54.90 Dorsalgia, unspecified (Multiple sites in spine)
0.695 0.305 0.000
M47.98 Spondylosis, unspecified (Sacral and sacrococcygeal region)
0.693 0.307 0.000
Y54.1 Mineralocorticoid antagonists [aldosterone antagonists]
0.693 0.307 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.693 0.307 0.000
M85.85 Other specified disorders of bone density and structure (Pelvic region and thigh)
0.691 0.309 0.000
M54.16 Radiculopathy (Lumbar region)
0.691 0.309 0.000
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified
0.691 0.309 0.000
Y45.8 Other analgesics and antipyretics
0.691 0.309 0.000
Y45.4 Antirheumatics
0.691 0.309 0.000
M54.97 Dorsalgia, unspecified (Lumbosacral region)
0.690 0.310 0.000
V89 Motor- or nonmotor-vehicle accident, type of vehicle unspecified
0.690 0.310 0.000
Y43.9 Primarily systemic agent, unspecified
0.690 0.310 0.000
Y43.8 Other primarily systemic agents, not elsewhere classified
0.690 0.310 0.000
Y43.6 Enzymes, not elsewhere classified
0.690 0.310 0.000
Y43.5 Acidifying and alkalising agents
0.690 0.310 0.000
Y43.2 Antineoplastic natural products
0.690 0.310 0.000
H31 Other disorders of choroid
0.690 0.310 0.000
C65 Malignant neoplasm of renal pelvis
0.690 0.310 0.000
M54.8 Other dorsalgia
0.687 0.313 0.000
M54.0 Panniculitis affecting regions of neck and back
0.687 0.313 0.000
C15-C26 Malignant neoplasms of digestive organs
0.687 0.313 0.000
C91.0 Acute lymphoblastic leukaemia
0.686 0.314 0.000
Y48 Anaesthetics and therapeutic gases
0.686 0.314 0.000
Y54.4 Loop [high-ceiling] diuretics
0.685 0.314 0.000
C64 Malignant neoplasm of kidney, except renal pelvis
0.685 0.315 0.000
V29 Motorcycle rider injured in other and unspecified transport accidents
0.683 0.317 0.000
E13 Other specified diabetes mellitus
0.682 0.318 0.000
M54.12 Radiculopathy (Cervical region)
0.681 0.319 0.000
M83 Adult osteomalacia
0.680 0.320 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.679 0.321 0.000
M47.86 Other spondylosis (Lumbar region)
0.679 0.321 0.000
V28 Motorcycle rider injured in noncollision transport accident
0.679 0.321 0.000
M41.95 Scoliosis, unspecified (Thoracolumbar region)
0.678 0.322 0.000
Y54.3 Benzothiadiazine derivatives
0.677 0.323 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.675 0.325 0.000
H30 Chorioretinal inflammation
0.675 0.325 0.000
M87.9 Osteonecrosis, unspecified
0.675 0.325 0.000
Y57.8 Other drugs and medicaments
0.675 0.325 0.000
H36.8 Other retinal disorders in diseases classified elsewhere
0.675 0.325 0.000
M46.92 Inflammatory spondylopathy, unspecified (Cervical region)
0.675 0.325 0.000
Q28 Other congenital malformations of circulatory system
0.674 0.326 0.000
Y57.9 Drug or medicament, unspecified
0.673 0.327 0.000
V40-V49 Car occupant injured in transport accident
0.673 0.327 0.000
M81.4 Drug-induced osteoporosis
0.672 0.328 0.000
M47.1 Other spondylosis with myelopathy
0.672 0.328 0.000
M81.98 Osteoporosis, unspecified (Other)
0.670 0.330 0.000
M47.88 Other spondylosis (Sacral and sacrococcygeal region)
0.670 0.330 0.000
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified
0.670 0.330 0.000
M47.95 Spondylosis, unspecified (Thoracolumbar region)
0.669 0.331 0.000
M47.94 Spondylosis, unspecified (Thoracic region)
0.669 0.331 0.000
M47.93 Spondylosis, unspecified (Cervicothoracic region)
0.669 0.331 0.000
M47.91 Spondylosis, unspecified (Occipito-atlanto-axial region)
0.669 0.331 0.000
C88.0 Waldenstrom's macroglobulinaemia
0.669 0.331 0.000
M41.99 Scoliosis, unspecified (Site unspecified)
0.669 0.331 0.000
H10 Conjunctivitis
0.668 0.331 0.000
Q27 Other congenital malformations of peripheral vascular system
0.668 0.332 0.000
W20-W49 Exposure to inanimate mechanical forces
0.668 0.332 0.000
M43.19 Spondylolisthesis (Site unspecified)
0.668 0.332 0.000
Chapter I Certain infectious and parasitic diseases
0.667 0.333 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.666 0.334 0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.666 0.334 0.000
E11.0 With coma
0.665 0.335 0.000
M54.54 Low back pain-Thoracic
0.663 0.337 0.000
M54.53 Low back pain-Cervicothoracic
0.663 0.337 0.000
M54.52 Low back pain-Cervical
0.663 0.337 0.000
M54.51 Low back pain-Occipit-atl-axl
0.663 0.337 0.000
M54.55 Low back pain (Thoracolumbar region)
0.663 0.337 0.000
E14.8 With unspecified complications
0.663 0.337 0.000
E14.7 With multiple complications
0.663 0.337 0.000
E14.6 With other specified complications
0.663 0.337 0.000
E14.5 With peripheral circulatory complications
0.663 0.337 0.000
E14.2 Withrenal complications
0.663 0.337 0.000
E14.1 With ketoacidosis
0.663 0.337 0.000
E14.0 With coma
0.663 0.337 0.000
M40.5 Lordosis, unspecified
0.663 0.337 0.000
Chapter VIII Diseases of the ear and mastoid process
0.663 0.337 0.000
Y57.5 X-ray contrast media
0.662 0.338 0.000
H18.4 Corneal degeneration
0.662 0.338 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.661 0.339 0.000
Y56.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified
0.661 0.339 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.661 0.339 0.000
M90.7 Fracture of bone in neoplastic disease
0.661 0.339 0.000
H54.5 Low vision, one eye
0.660 0.340 0.000
H11.4 Other conjunctival vascular disorders and cysts
0.660 0.340 0.000
H11.8 Other specified disorders of conjunctiva
0.660 0.340 0.000
M86.99 Osteomyelitis, unspecified (Site unspecified)
0.659 0.340 0.000
M46.97 Inflammatory spondylopathy, unspecified (Lumbosacral region)
0.659 0.341 0.000
C67.4 Posterior wall of bladder
0.659 0.341 0.000
E11.5 With peripheral circulatory complications
0.659 0.341 0.000
E61.1 Iron deficiency
0.659 0.341 0.000
H53 Visual disturbances
0.659 0.341 0.000
M81.8 Other osteoporosis
0.659 0.341 0.000
M81.6 Localised osteoporosis [Lequesne]
0.659 0.341 0.000
M81.5 Idiopathic osteoporosis
0.659 0.341 0.000
M81.3 Postsurgical malabsorption osteoporosis
0.659 0.341 0.000
M81.1 Postoophorectomy osteoporosis
0.659 0.341 0.000
M81.0 Postmenopausal osteoporosis
0.659 0.341 0.000
M43.9 Deforming dorsopathy, unspecified
0.657 0.342 0.000
M43.8 Other specified deforming dorsopathies
0.657 0.342 0.000
M43.6 Torticollis
0.657 0.342 0.000
M43.5 Other recurrent vertebral subluxation
0.657 0.342 0.000
M43.4 Other recurrent atlantoaxial subluxation
0.657 0.342 0.000
M43.3 Recurrent atlantoaxial subluxation with myelopathy
0.657 0.342 0.000
M43.2 Other fusion of spine
0.657 0.342 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.657 0.343 0.000
M54.98 Dorsalgia, unspecified (Sacral and sacrococcygeal region)
0.657 0.343 0.000
E11.8 With unspecified complications
0.655 0.344 0.000
M41.8 Other forms of scoliosis
0.655 0.345 0.000
Y46.6 Other and unspecified antiepileptics
0.654 0.346 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.652 0.348 0.000
M90.1 Periostitis in other infectious diseases classified elsewhere
0.651 0.349 0.000
M47.84 Other spondylosis (Thoracic region)
0.648 0.351 0.000
M53.8 Other specified dorsopathies
0.648 0.352 0.000
Y42.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.647 0.353 0.000
M46.8 Other specified inflammatory spondylopathies
0.647 0.353 0.000
M46.5 Other infective spondylopathies
0.647 0.353 0.000
M46.3 Infection of intervertebral disk (pyogenic)
0.647 0.353 0.000
M46.2 Osteomyelitis of vertebra
0.647 0.353 0.000
M46.1 Sacro-iliitis, not elsewhere classified
0.647 0.353 0.000
M46.0 Spinal enthesopathy
0.647 0.353 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.646 0.353 0.000
M86.8 Other osteomyelitis
0.646 0.354 0.000
M86.6 Other chronic osteomyelitis
0.646 0.354 0.000
M86.5 Other chronic haematogenous osteomyelitis
0.646 0.354 0.000
M86.4 Chronic osteomyelitis with draining sinus
0.646 0.354 0.000
M86.3 Chronic multifocal osteomyelitis
0.646 0.354 0.000
M86.2 Subacute osteomyelitis
0.646 0.354 0.000
M86.1 Other acute osteomyelitis
0.646 0.354 0.000
M86.0 Acute haematogenous osteomyelitis
0.646 0.354 0.000
M54.19 Radiculopathy (Site unspecified)
0.646 0.354 0.000
M48.9 Spondylopathy, unspecified
0.645 0.354 0.000
M48.8 Other specified spondylopathies
0.645 0.354 0.000
M48.4 Fatigue fracture of vertebra
0.645 0.354 0.000
M48.3 Traumatic spondylopathy
0.645 0.354 0.000
M48.2 Kissing spine
0.645 0.354 0.000
M48.1 Ankylosing hyperostosis [Forestier]
0.645 0.354 0.000
Y52 Agents primarily affecting the cardiovascular system
0.645 0.355 0.000
M81.96 Osteoporosis, unspecified (Lower leg)
0.645 0.355 0.000
M81.94 Osteoporosis, unspecified (Hand)
0.645 0.355 0.000
M81.93 Osteoporosis, unspecified (Forearm)
0.645 0.355 0.000
M81.92 Osteoporosis, unspecified (Upper arm)
0.645 0.355 0.000
M81.91 Osteoporosis, unspecified (Shoulder region)
0.645 0.355 0.000
Y51.9 Other and unspecified drugs primarily affecting the autonomic nervous system
0.642 0.358 0.000
Y51.8 Centrally acting and adrenergic-neuron-blocking agents, not elsewhere classified
0.642 0.358 0.000
Y51.6 @-Adrenoreceptor antagonists, not elsewhere classified
0.642 0.358 0.000
Y51.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified
0.642 0.358 0.000
Y51.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified
0.642 0.358 0.000
Y51.3 Other parasympatholytics [anticholinergics and antimuscarinics] and spasmolytics, not elsewhere classified
0.642 0.358 0.000
Y51.2 Ganglionic blocking drugs, not elsewhere classified
0.642 0.358 0.000
Y51.1 Other parasympathomimetics [cholinergics]
0.642 0.358 0.000
Y51.0 Anticholinesterase agents
0.642 0.358 0.000
M41.5 Other secondary scoliosis
0.640 0.360 0.000
M41.4 Neuromuscular scoliosis
0.640 0.360 0.000
M41.3 Thoracogenic scoliosis
0.640 0.360 0.000
M41.2 Other idiopathic scoliosis
0.640 0.360 0.000
M41.1 Juvenile idiopathic scoliosis
0.640 0.360 0.000
M41.0 Infantile idiopathic scoliosis
0.640 0.360 0.000
M51.3 Other specified intervertebral disk degeneration
0.639 0.361 0.000
M51.1 Lumbar and other intervertebral disk disorders with radiculopathy
0.639 0.361 0.000
M54.96 Dorsalgia, unspecified (Lumbar region)
0.638 0.362 0.000
M82 Osteoporosis in diseases classified elsewhere
0.635 0.364 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.635 0.365 0.000
C37 Malignant neoplasm of thymus
0.635 0.365 0.000
H11.1 Conjunctival degenerations and deposits
0.634 0.366 0.000
H13 Disorders of conjunctiva in diseases classified elsewhere
0.634 0.366 0.000
M85.89 Other specified disorders of bone density and structure (Site unspecified)
0.634 0.366 0.000
C68 Malignant neoplasm of other and unspecified urinary organs
0.632 0.368 0.000
E11.6 With other specified complications
0.631 0.369 0.000
C92.9 Myeloid leukaemia, unspecified
0.630 0.370 0.000
C92.8 Acute myeloid leukaemia with multilineage dysplasia
0.630 0.370 0.000
C92.7 Other myeloid leukaemia
0.630 0.370 0.000
C92.6 Acute myeloid leukaemia with 11q23-abnormality
0.630 0.370 0.000
C92.5 Acute myelomonocytic leukaemia
0.630 0.370 0.000
C92.4 Acute promyelocytic leukaemia
0.630 0.370 0.000
C92.3 Myeloid sarcoma
0.630 0.370 0.000
C92.2 Subacute myeloid leukaemia
0.630 0.370 0.000
Y46.4 Iminostilbenes
0.628 0.372 0.000
H16 Keratitis
0.627 0.373 0.000
M81.97 Osteoporosis, unspecified (Ankle and foot)
0.627 0.373 0.000
M92 Other juvenile osteochondrosis
0.626 0.373 0.000
E15 Nondiabetic hypoglycaemic coma
0.626 0.374 0.000
M89 Other disorders of bone
0.626 0.374 0.000
M48.09 Spinal stenosis (Site unspecified)
0.626 0.374 0.000
M54.50 Low back pain (Multiple sites in spine)
0.626 0.374 0.000
M46.99 Inflammatory spondylopathy, unspecified (Site unspecified)
0.625 0.374 0.000
M66 Spontaneous rupture of synovium and tendon
0.624 0.376 0.000
M47.97 Spondylosis, unspecified (Lumbosacral region)
0.623 0.376 0.000
X60 Intentional self-poisoning by and exposure to nonopioid analgesics, antipyretics and antirheumatics
0.623 0.377 0.000
M85.87 Other specified disorders of bone density and structure (Ankle and foot)
0.623 0.377 0.000
X69.0 Home
0.622 0.378 0.000
M81.2 Osteoporosis of disuse
0.622 0.378 0.000
X84 Intentional self-harm by unspecified means
0.621 0.379 0.000
X83 Intentional self-harm by other specified means
0.621 0.379 0.000
X82 Intentional self-harm by crashing of motor vehicle
0.621 0.379 0.000
X81 Intentional self-harm by jumping or lying before moving object
0.621 0.379 0.000
X80 Intentional self-harm by jumping from a high place
0.621 0.379 0.000
X79 Intentional self-harm by blunt object
0.621 0.379 0.000
X77 Intentional self-harm by steam, hot vapours and hot objects
0.621 0.379 0.000
X76 Intentional self-harm by smoke, fire and flames
0.621 0.379 0.000
X75 Intentional self-harm by explosive material
0.621 0.379 0.000
X74 Intentional self-harm by other and unspecified firearm discharge
0.621 0.379 0.000
X73 Intentional self-harm by rifle, shotgun and larger firearm discharge
0.621 0.379 0.000
X72 Intentional self-harm by handgun discharge
0.621 0.379 0.000
X71 Intentional self-harm by drowning and submersion
0.621 0.379 0.000
X70 Intentional self-harm by hanging, strangulation and suffocation
0.621 0.379 0.000
X68 Intentional self-poisoning by and exposure to pesticides
0.621 0.379 0.000
X67 Intentional self-poisoning by and exposure to other gases and vapours
0.621 0.379 0.000
X66 Intentional self-poisoning by and exposure to organic solvents and halogenated hydrocarbons and their vapours
0.621 0.379 0.000
X65 Intentional self-poisoning by and exposure to alcohol
0.621 0.379 0.000
X64 Intentional self-poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
0.621 0.379 0.000
X61 Intentional self-poisoning by and exposure to antiepileptic, sedative-hypnotic, anti-Parkinsonism and psychotropic drugs, not elsewhere classified
0.621 0.379 0.000
Q00-Q07 Congenital malformations of the nervous system
0.621 0.379 0.000
H17 Corneal scars and opacities
0.620 0.380 0.000
V26 Motorcycle rider injured in collision with other nonmotor vehicle
0.620 0.380 0.000
V25 Motorcycle rider injured in collision with railway train or railway vehicle
0.620 0.380 0.000
V24 Motorcycle rider injured in collision with heavy transport vehicle or bus
0.620 0.380 0.000
V22 Motorcycle rider injured in collision with two- or three-wheeled motor vehicle
0.620 0.380 0.000
V21 Motorcycle rider injured in collision with pedal cycle
0.620 0.380 0.000
V20 Motorcycle rider injured in collision with pedestrian or animal
0.620 0.380 0.000
M54.95 Dorsalgia, unspecified (Thoracolumbar region)
0.619 0.380 0.000
M54.93 Dorsalgia, unspecified (Cervicothoracic region)
0.619 0.380 0.000
M54.92 Dorsalgia, unspecified (Cervical region)
0.619 0.380 0.000
M54.91 Dorsalgia, unspecified (Occipito-atlanto-axial region)
0.619 0.380 0.000
Y54.9 Mineral salts, not elsewhere classified
0.619 0.381 0.000
Y54.8 Agents affecting uric acid metabolism
0.619 0.381 0.000
Y54.7 Agents affecting calcification
0.619 0.381 0.000
Y54.6 Electrolytic, caloric and water-balance agents
0.619 0.381 0.000
Y54.5 Other diuretics
0.619 0.381 0.000
Y54.2 Carbonic-anhydrase inhibitors
0.619 0.381 0.000
Y54.0 Mineralocorticoids
0.619 0.381 0.000
M86.98 Osteomyelitis, unspecified (Other)
0.618 0.381 0.000
M86.93 Osteomyelitis, unspecified (Forearm)
0.618 0.381 0.000
M86.92 Osteomyelitis, unspecified (Upper arm)
0.618 0.381 0.000
M86.91 Osteomyelitis, unspecified (Shoulder region)
0.618 0.381 0.000
M86.90 Osteomyelitis, unspecified (Multiple sites)
0.618 0.381 0.000
V27 Motorcycle rider injured in collision with fixed or stationary object
0.618 0.381 0.000
M93 Other osteochondropathies
0.617 0.382 0.000
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified
0.617 0.383 0.000
Q51 Congenital malformations of uterus and cervix
0.617 0.383 0.000
Y42.0 Glucocorticoids and synthetic analogs
0.616 0.384 0.000
M85.9 Disorder of bone density and structure, unspecified
0.616 0.384 0.000
M85.5 Aneurysmal bone cyst
0.616 0.384 0.000
M85.4 Solitary bone cyst
0.616 0.384 0.000
M85.3 Osteitis condensans
0.616 0.384 0.000
M85.2 Hyperostosis of skull
0.616 0.384 0.000
M85.1 Skeletal fluorosis
0.616 0.384 0.000
M43.18 Spondylolisthesis (Sacral and sacrococcygeal region)
0.615 0.385 0.000
M43.15 Spondylolisthesis (Thoracolumbar region)
0.615 0.385 0.000
M43.14 Spondylolisthesis (Thoracic region)
0.615 0.385 0.000
M43.13 Spondylolisthesis (Cervicothoracic region)
0.615 0.385 0.000
M43.12 Spondylolisthesis (Cervical region)
0.615 0.385 0.000
M43.11 Spondylolisthesis (Occipito-atlanto-axial region)
0.615 0.385 0.000
M43.10 Spondylolisthesis (Multiple sites in spine)
0.615 0.385 0.000
Y42.5 Other oestrogens and progestogens
0.613 0.387 0.000
Y57.7 Vitamins, not elsewhere classified
0.611 0.389 0.000
Y57.6 Other diagnostic agents
0.611 0.389 0.000
Y57.4 Pharmaceutical excipients
0.611 0.389 0.000
Y57.3 Alcohol deterrents
0.611 0.389 0.000
Y57.2 Antidotes and chelating agents, not elsewhere classified
0.611 0.389 0.000
Y57.1 Lipotropic drugs
0.611 0.389 0.000
Y57.0 Appetite depressants [anorectics]
0.611 0.389 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.611 0.389 0.000
X10 Contact with hot drinks, food, fats and cooking oils
0.611 0.389 0.000
C82.3 Follicular lymphoma grade IIIa
0.609 0.391 0.000
M88 Paget's disease of bone [osteitis deformans]
0.609 0.391 0.000
C41 Malignant neoplasm of bone and articular cartilage of other and unspecified sites
0.608 0.392 0.000
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.608 0.392 0.000
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.608 0.392 0.000
H15 Disorders of sclera
0.608 0.392 0.000
M54.94 Dorsalgia, unspecified (Thoracic region)
0.608 0.392 0.000
M40.4 Other lordosis
0.608 0.392 0.000
M40.3 Flatback syndrome
0.608 0.392 0.000
M40.1 Other secondary kyphosis
0.608 0.392 0.000
M40.0 Postural kyphosis
0.608 0.392 0.000
H53.0 Amblyopia ex anopsia
0.608 0.392 0.000
M46.49 Discitis, unspecified (Site unspecified)
0.607 0.393 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.607 0.393 0.000
Q35-Q37 Cleft lip and cleft palate
0.607 0.393 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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