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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs4766578
log Bayes Factor = 133.156
Chromosome 12   position 111,904,371  (GRCh37) Explore rs4766578 on Ensembl!
Variant rs4766578 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
C77.3 Axillary and upper limb lymph nodes
1.000 0.000 0.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.000 1.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.000 1.000
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.000 1.000
I10 Essential (primary) hypertension
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
I21 Acute myocardial infarction
0.000 0.000 1.000
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
Chapter IX Diseases of the circulatory system
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
I25.2 Old myocardial infarction
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
I20.9 Angina pectoris, unspecified
0.000 0.000 1.000
Z95.1 Presence of aortocoronary bypass graft
0.000 0.000 1.000
I10-I15 Hypertensive diseases
0.000 0.000 1.000
E20-E35 Disorders of other endocrine glands
0.000 0.000 1.000
I20 Angina pectoris
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.999 0.001 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.998 0.002 0.000
Z95.2 Presence of prosthetic heart valve
0.000 0.002 0.998
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.004 0.996
E05.9 Thyrotoxicosis, unspecified
0.000 0.004 0.996
C50 Malignant neoplasm of breast
0.995 0.005 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.006 0.994
Z95.4 Presence of other heart-valve replacement
0.000 0.008 0.992
I21.9 Acute myocardial infarction, unspecified
0.000 0.008 0.992
C50.9 Breast, unspecified
0.991 0.009 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.009 0.991
I22 Subsequent myocardial infarction
0.000 0.010 0.990
# Top node
0.000 0.010 0.990
G80-G83 Cerebral palsy and other paralytic syndromes
0.000 0.015 0.985
D55-D59 Haemolytic anaemias
0.000 0.015 0.985
I74 Arterial embolism and thrombosis
0.000 0.015 0.985
G81 Hemiplegia
0.000 0.016 0.984
Chapter VI Diseases of the nervous system
0.000 0.016 0.984
E27 Other disorders of adrenal gland
0.000 0.017 0.983
G81.9 Hemiplegia, unspecified
0.000 0.017 0.983
E10.5 With peripheral circulatory complications
0.000 0.020 0.980
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.021 0.979
C79 Secondary malignant neoplasm of other sites
0.979 0.021 0.000
D75 Other diseases of blood and blood-forming organs
0.000 0.021 0.979
E06 Thyroiditis
0.000 0.021 0.979
C50.4 Upper-outer quadrant of breast
0.976 0.024 0.000
E23 Hypofunction and other disorders of pituitary gland
0.000 0.026 0.974
E10.9 Without complications
0.000 0.027 0.973
I25.5 Ischaemic cardiomyopathy
0.000 0.028 0.972
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.029 0.971
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.969 0.031 0.000
D75.1 Secondary polycythaemia
0.000 0.032 0.968
G20-G26 Extrapyramidal and movement disorders
0.000 0.033 0.967
E27.1 Primary adrenocortical insufficiency
0.000 0.034 0.966
C50-C50 Malignant neoplasm of breast
0.964 0.036 0.000
C78.7 Secondary malignant neoplasm of liver
0.962 0.038 0.000
E10.1 With ketoacidosis
0.000 0.041 0.959
D59 Acquired haemolytic anaemia
0.000 0.041 0.959
G24 Dystonia
0.000 0.042 0.958
E10.4 With neurological complications
0.000 0.045 0.955
C50.8 Overlapping lesion of breast
0.950 0.050 0.000
Z95.8 Presence of other cardiac and vascular implants and grafts
0.000 0.051 0.949
E10.3 With ophthalmic complications
0.000 0.052 0.948
E06.3 Autoimmune thyroiditis
0.000 0.054 0.946
G24.9 Dystonia, unspecified
0.000 0.057 0.943
Chapter II Neoplasms
0.943 0.057 0.000
G83 Other paralytic syndromes
0.000 0.058 0.942
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.060 0.940
D75.2 Essential thrombocytosis
0.000 0.063 0.937
K90 Intestinal malabsorption
0.000 0.063 0.937
I73 Other peripheral vascular diseases
0.000 0.065 0.935
D59.1 Other autoimmune haemolytic anaemias
0.000 0.066 0.934
C79.8 Secondary malignant neoplasm of other specified sites
0.931 0.069 0.000
C50.1 Central portion of breast
0.930 0.070 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.076 0.924
G70-G73 Diseases of myoneural junction and muscle
0.000 0.077 0.923
C50.0 Nipple and areola
0.919 0.081 0.000
I73.9 Peripheral vascular disease, unspecified
0.000 0.082 0.918
K74 Fibrosis and cirrhosis of liver
0.000 0.082 0.918
I74.5 Embolism and thrombosis of iliac artery
0.000 0.084 0.916
K74.3 Primary biliary cirrhosis
0.000 0.085 0.915
K70-K77 Diseases of liver
0.000 0.085 0.915
K90-K93 Other diseases of the digestive system
0.000 0.087 0.913
Chapter XI Diseases of the digestive system
0.000 0.088 0.912
E10.2 With renal complications
0.000 0.089 0.910
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.909 0.091 0.000
C77.9 Lymph node, unspecified
0.906 0.094 0.000
E10.0 With coma
0.000 0.094 0.906
I77 Other disorders of arteries and arterioles
0.000 0.095 0.905
E23.6 Other disorders of pituitary gland
0.000 0.101 0.899
G80 Infantile cerebral palsy
0.000 0.101 0.898
E23.2 Diabetes insipidus
0.000 0.103 0.897
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.105 0.895
E50-E64 Other nutritional deficiencies
0.000 0.105 0.895
G83.4 Cauda equina syndrome
0.000 0.107 0.893
C79.1 Secondary malignant neoplasm of bladder and other and unspecified urinary organs
0.889 0.111 0.000
I25.3 Aneurysm of heart
0.000 0.114 0.886
I23 Certain current complications following acute myocardial infarction
0.000 0.116 0.884
C78.2 Secondary malignant neoplasm of pleura
0.883 0.117 0.000
D58 Other hereditary haemolytic anaemias
0.000 0.117 0.883
I21.4 Acute subendocardial myocardial infarction
0.000 0.121 0.879
K73 Chronic hepatitis, not elsewhere classified
0.000 0.124 0.876
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.125 0.875
E28 Ovarian dysfunction
0.000 0.125 0.875
C50.2 Upper-inner quadrant of breast
0.871 0.129 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.130 0.870
D56 Thalassaemia
0.000 0.134 0.866
E07 Other disorders of thyroid
0.000 0.136 0.864
E22 Hyperfunction of pituitary gland
0.000 0.139 0.861
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.149 0.851
D69 Purpura and other haemorrhagic conditions
0.000 0.151 0.849
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.849 0.151 0.000
I77.6 Arteritis, unspecified
0.000 0.155 0.845
C77.8 Lymph nodes of multiple regions
0.842 0.158 0.000
E21.3 Hyperparathyroidism, unspecified
0.000 0.158 0.842
E06.9 Thyroiditis, unspecified
0.000 0.158 0.842
G25 Other extrapyramidal and movement disorders
0.000 0.161 0.839
E34 Other endocrine disorders
0.000 0.161 0.839
G24.5 Blepharospasm
0.000 0.163 0.837
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system
0.836 0.164 0.000
C79.7 Secondary malignant neoplasm of adrenal gland
0.836 0.164 0.000
E27.2 Addisonian crisis
0.000 0.166 0.834
G80.9 Infantile cerebral palsy, unspecified
0.000 0.170 0.830
C84 Peripheral and cutaneous T-cell lymphomas
0.828 0.172 0.000
I05-I09 Chronic rheumatic heart diseases
0.000 0.173 0.827
E23.0 Hypopituitarism
0.000 0.176 0.824
K75 Other inflammatory liver diseases
0.000 0.177 0.823
D60-D64 Aplastic and other anaemias
0.000 0.178 0.822
I77.1 Stricture of artery
0.000 0.180 0.820
C76 Malignant neoplasm of other and ill-defined sites
0.820 0.180 0.000
I12 Hypertensive renal disease
0.000 0.182 0.818
G71 Primary disorders of muscles
0.000 0.182 0.818
E20 Hypoparathyroidism
0.000 0.183 0.817
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.184 0.816
K74.0 Hepatic fibrosis
0.000 0.185 0.815
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum
0.813 0.187 0.000
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.188 0.812
K73.2 Chronic active hepatitis, not elsewhere classified
0.000 0.189 0.811
E27.8 Other specified disorders of adrenal gland
0.000 0.190 0.810
D63 Anaemia in chronic diseases classified elsewhere
0.000 0.192 0.808
E03.8 Other specified hypothyroidism
0.000 0.193 0.807
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.807 0.193 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.197 0.803
D63.8 Anaemia in other chronic diseases classified elsewhere
0.000 0.197 0.803
G72 Other myopathies
0.000 0.198 0.802
I23.8 Other current complications following acute myocardial infarction
0.000 0.200 0.800
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.800 0.200 0.000
E07.9 Disorder of thyroid, unspecified
0.000 0.207 0.793
E31 Polyglandular dysfunction
0.000 0.207 0.793
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.209 0.791
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.209 0.791
C79.0 Secondary malignant neoplasm of kidney and renal pelvis
0.790 0.210 0.000
K74.5 Biliary cirrhosis, unspecified
0.000 0.212 0.788
E21.0 Primary hyperparathyroidism
0.000 0.214 0.786
G83.9 Paralytic syndrome, unspecified
0.000 0.216 0.784
I22.8 Subsequent myocardial infarction of other sites
0.000 0.218 0.782
E58 Dietary calcium deficiency
0.000 0.219 0.781
D69.4 Other primary thrombocytopenia
0.000 0.227 0.773
C79.5 Secondary malignant neoplasm of bone and bone marrow
0.771 0.229 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.766 0.234 0.000
D56.3 Thalassaemia trait
0.000 0.234 0.766
M06.9 Rheumatoid arthritis, unspecified
0.000 0.236 0.764
I25.6 Silent myocardial ischaemia
0.000 0.237 0.763
C77.4 Inguinal and lower limb lymph nodes
0.763 0.237 0.000
E03.1 Congenital hypothyroidism without goitre
0.000 0.238 0.762
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.238 0.762
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.239 0.761
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.240 0.760
E22.1 Hyperprolactinaemia
0.000 0.240 0.760
E28.3 Primary ovarian failure
0.000 0.241 0.759
G83.1 Monoplegia of lower limb
0.000 0.246 0.754
G25.0 Essential tremor
0.000 0.246 0.754
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.246 0.754
E14 Unspecified diabetes mellitus
0.000 0.247 0.753
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.250 0.750
E40-E46 Malnutrition
0.000 0.250 0.750
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.251 0.749
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.253 0.747
E06.1 Subacute thyroiditis
0.000 0.254 0.746
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.257 0.743
C90 Multiple myeloma and malignant plasma cell neoplasms
0.743 0.257 0.000
C85.7 Other specified types of non-Hodgkin's lymphoma
0.740 0.260 0.000
C78.4 Secondary malignant neoplasm of small intestine
0.735 0.265 0.000
K75.4 Autoimmune hepatitis
0.000 0.265 0.735
C77.2 Intra-abdominal lymph nodes
0.734 0.266 0.000
I25.4 Coronary artery aneurysm
0.000 0.266 0.734
G24.1 Idiopathic familial dystonia
0.000 0.268 0.732
E10.8 With unspecified complications
0.000 0.268 0.731
I07 Rheumatic tricuspid valve diseases
0.000 0.269 0.731
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.270 0.730
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.270 0.730
C84.0 Mycosis fungoides
0.728 0.272 0.000
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.725 0.275 0.000
G80.2 Infantile hemiplegia
0.000 0.277 0.723
D73 Diseases of spleen
0.000 0.278 0.722
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.278 0.722
K73.9 Chronic hepatitis, unspecified
0.000 0.281 0.719
G71.1 Myotonic disorders
0.000 0.283 0.717
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.283 0.717
E30 Disorders of puberty, not elsewhere classified
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
I15 Secondary hypertension
0.000 0.284 0.716
I05 Rheumatic mitral valve diseases
0.000 0.284 0.716
C51-C58 Malignant neoplasms of female genital organs
0.716 0.284 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.715 0.285 0.000
E05.5 Thyroid crisis or storm
0.000 0.286 0.714
E05.4 Thyrotoxicosis factitia
0.000 0.286 0.714
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.286 0.714
G72.9 Myopathy, unspecified
0.000 0.288 0.712
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.290 0.710
K73.8 Other chronic hepatitis, not elsewhere classified
0.000 0.290 0.710
E25 Adrenogenital disorders
0.000 0.291 0.708
D55 Anaemia due to enzyme disorders
0.000 0.294 0.706
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.294 0.706
G81.0 Flaccid hemiplegia
0.000 0.295 0.705
E27.5 Adrenomedullary hyperfunction
0.000 0.295 0.705
E27.0 Other adrenocortical overactivity
0.000 0.295 0.705
C94 Other leukaemias of specified cell type
0.703 0.297 0.000
D74 Methaemoglobinaemia
0.000 0.298 0.702
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.298 0.702
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.298 0.702
E06.4 Drug-induced thyroiditis
0.000 0.298 0.702
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.298 0.702
E06.0 Acute thyroiditis
0.000 0.298 0.702
E53 Deficiency of other B group vitamins
0.000 0.299 0.701
E61 Deficiency of other nutrient elements
0.000 0.299 0.701
K75.3 Granulomatous hepatitis, not elsewhere classified
0.000 0.299 0.701
C79.2 Secondary malignant neoplasm of skin
0.700 0.300 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.302 0.698
E23.1 Drug-induced hypopituitarism
0.000 0.302 0.698
D57 Sickle-cell disorders
0.000 0.302 0.698
G70 Myasthenia gravis and other myoneural disorders
0.000 0.305 0.695
C86 Other specified types of T/NK-cell lymphoma
0.695 0.305 0.000
E34.0 Carcinoid syndrome
0.000 0.305 0.695
G24.8 Other dystonia
0.000 0.306 0.694
G26 Extrapyramidal and movement disorders in diseases classified elsewhere
0.000 0.307 0.693
G22 Parkinsonism in diseases classified elsewhere
0.000 0.307 0.693
E55 Vitamin D deficiency
0.000 0.307 0.693
G25.2 Other specified forms of tremor
0.000 0.308 0.692
E32 Diseases of thymus
0.000 0.309 0.691
I13 Hypertensive heart and renal disease
0.000 0.309 0.691
G24.3 Spasmodic torticollis
0.000 0.312 0.688
D59.8 Other acquired haemolytic anaemias
0.000 0.313 0.687
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.313 0.687
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.313 0.687
D59.3 Haemolytic-uraemic syndrome
0.000 0.313 0.687
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.313 0.687
G24.4 Idiopathic orofacial dystonia
0.000 0.313 0.687
G24.2 Idiopathic nonfamilial dystonia
0.000 0.313 0.687
E20.9 Hypoparathyroidism, unspecified
0.000 0.314 0.686
Z95.3 Presence of xenogenic heart valve
0.000 0.316 0.684
E10.6 With other specified complications
0.000 0.317 0.683
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.317 0.683
E28.2 Polycystic ovarian syndrome
0.000 0.318 0.682
G23 Other degenerative diseases of basal ganglia
0.000 0.320 0.680
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.323 0.677
C84.4 Peripheral T-cell lymphoma
0.677 0.323 0.000
G24.0 Drug-induced dystonia
0.000 0.323 0.677
C76.0 Head, face and neck
0.677 0.323 0.000
G81.1 Spastic hemiplegia
0.000 0.323 0.677
G83.5 Locked-in syndrome
0.000 0.324 0.676
G83.3 Monoplegia, unspecified
0.000 0.324 0.676
G83.0 Diplegia of upper limbs
0.000 0.324 0.676
I77.2 Rupture of artery
0.000 0.324 0.676
D75.0 Familial erythrocytosis
0.000 0.324 0.675
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.325 0.675
D58.0 Hereditary spherocytosis
0.000 0.327 0.673
E14.3 With ophthalmic complications
0.000 0.327 0.673
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.327 0.673
I77.0 Arteriovenous fistula, acquired
0.000 0.327 0.673
K90.3 Pancreatic steatorrhoea
0.000 0.328 0.671
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.328 0.671
K90.1 Tropical sprue
0.000 0.328 0.671
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.329 0.671
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.330 0.670
K71 Toxic liver disease
0.000 0.332 0.668
I12.9 Hypertensive renal disease without renal failure
0.000 0.333 0.667
I00-I02 Acute rheumatic fever
0.000 0.333 0.667
C82.0 Small cleaved cell, follicular
0.667 0.333 0.000
E51 Thiamine deficiency
0.000 0.335 0.665
G73 Disorders of myoneural junction and muscle in diseases classified elsewhere
0.000 0.338 0.662
I07.1 Tricuspid insufficiency
0.000 0.338 0.662
E06.5 Other chronic thyroiditis
0.000 0.338 0.662
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.662 0.338 0.000
G21 Secondary Parkinsonism
0.000 0.341 0.659
E34.9 Endocrine disorder, unspecified
0.000 0.341 0.659
G25.3 Myoclonus
0.000 0.341 0.659
E26 Hyperaldosteronism
0.000 0.342 0.658
K74.4 Secondary biliary cirrhosis
0.000 0.342 0.658
K74.2 Hepatic fibrosis with hepatic sclerosis
0.000 0.342 0.658
D56.1 Beta thalassaemia
0.000 0.343 0.657
K77 Liver disorders in diseases classified elsewhere
0.000 0.344 0.656
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.345 0.655
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.345 0.655
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.346 0.654
G80.0 Spastic cerebral palsy
0.000 0.348 0.652
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.652 0.348 0.000
E21.2 Other hyperparathyroidism
0.000 0.349 0.651
I77.5 Necrosis of artery
0.000 0.351 0.649
I77.4 Coeliac artery compression syndrome
0.000 0.351 0.649
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs
0.648 0.352 0.000
G25.9 Extrapyramidal and movement disorder, unspecified
0.000 0.353 0.647
D58.2 Other haemoglobinopathies
0.000 0.353 0.647
C49 Malignant neoplasm of other connective and soft tissue
0.646 0.354 0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts
0.000 0.355 0.645
C51 Malignant neoplasm of vulva
0.645 0.355 0.000
E31.0 Autoimmune polyglandular failure
0.000 0.355 0.644
G80.4 Ataxic cerebral palsy
0.000 0.356 0.644
G80.3 Dyskinetic cerebral palsy
0.000 0.356 0.644
C95 Leukaemia of unspecified cell type
0.644 0.356 0.000
G72.8 Other specified myopathies
0.000 0.357 0.643
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.357 0.642
K74.6 Other and unspecified cirrhosis of liver
0.000 0.358 0.642
I05.0 Mitral stenosis
0.000 0.358 0.642
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.359 0.641
E63 Other nutritional deficiencies
0.000 0.359 0.641
E50 Vitamin A deficiency
0.000 0.359 0.641
E60 Dietary zinc deficiency
0.000 0.359 0.641
E59 Dietary selenium deficiency
0.000 0.359 0.641
E52 Niacin deficiency [pellagra]
0.000 0.359 0.641
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.000 0.360 0.640
C97 Malignant neoplasms of independent (primary) multiple sites
0.639 0.361 0.000
G25.1 Drug-induced tremor
0.000 0.364 0.636
C15-C26 Malignant neoplasms of digestive organs
0.636 0.364 0.000
C81 Hodgkin's disease
0.636 0.364 0.000
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.366 0.633
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.366 0.633
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.366 0.633
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.366 0.633
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.366 0.633
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.366 0.633
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.366 0.633
C76.1 Thorax
0.633 0.367 0.000
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.367 0.633
D58.1 Hereditary elliptocytosis
0.000 0.367 0.633
C93 Monocytic leukaemia
0.633 0.367 0.000
I72 Other aneurysm
0.000 0.367 0.633
C90.1 Plasma cell leukaemia
0.631 0.369 0.000
G71.3 Mitochondrial myopathy, not elsewhere classified
0.000 0.369 0.631
K73.1 Chronic lobular hepatitis, not elsewhere classified
0.000 0.372 0.628
K73.0 Chronic persistent hepatitis, not elsewhere classified
0.000 0.372 0.628
C84.5 Other and unspecified T-cell lymphomas
0.628 0.372 0.000
G83.2 Monoplegia of upper limb
0.000 0.372 0.628
E28.9 Ovarian dysfunction, unspecified
0.000 0.373 0.627
E28.8 Other ovarian dysfunction
0.000 0.373 0.627
E28.1 Androgen excess
0.000 0.373 0.627
E28.0 Oestrogen excess
0.000 0.373 0.627
E21.4 Other specified disorders of parathyroid gland
0.000 0.374 0.626
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.374 0.626
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.374 0.626
E05.8 Other thyrotoxicosis
0.000 0.376 0.624
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.377 0.623
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.377 0.623
D56.9 Thalassaemia, unspecified
0.000 0.379 0.621
D56.8 Other thalassaemias
0.000 0.379 0.621
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.000 0.379 0.621
D56.2 Delta-beta thalassaemia
0.000 0.379 0.621
D56.0 Alpha thalassaemia
0.000 0.379 0.621
C88 Malignant immunoproliferative diseases
0.620 0.380 0.000
E07.1 Dyshormogenetic goitre
0.000 0.381 0.619
E07.0 Hypersecretion of calcitonin
0.000 0.381 0.619
K74.1 Hepatic sclerosis
0.000 0.381 0.619
E34.3 Short stature, not elsewhere classified
0.000 0.382 0.618
I12.0 Hypertensive renal disease with renal failure
0.000 0.382 0.618
C55 Malignant neoplasm of uterus, part unspecified
0.618 0.382 0.000
E22.8 Other hyperfunction of pituitary gland
0.000 0.382 0.618
K90.8 Other intestinal malabsorption
0.000 0.382 0.617
D73.3 Abscess of spleen
0.000 0.383 0.617
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.384 0.616
E10.7 With multiple complications
0.000 0.385 0.615
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.000 0.386 0.614
I77.3 Arterial fibromuscular dysplasia
0.000 0.387 0.613
I05.2 Mitral stenosis with insufficiency
0.000 0.387 0.613
C82.4 Follicular lymphoma grade IIIb
0.610 0.390 0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.391 0.609
C85.0 Lymphosarcoma
0.608 0.391 0.000
G83.8 Other specified paralytic syndromes
0.000 0.393 0.607
T82.1 Mechanical complication of cardiac electronic device
0.000 0.393 0.607
G80.8 Other infantile cerebral palsy
0.000 0.394 0.606
I20.0 Unstable angina
0.000 0.394 0.606
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.606 0.394 0.000
C80 Malignant neoplasm without specification of site
0.603 0.397 0.000
D69.8 Other specified haemorrhagic conditions
0.000 0.397 0.603
C82.1 Mixed small cleaved and large cell, follicular
0.602 0.398 0.000
G25.6 Drug-induced tics and other tics of organic origin
0.000 0.398 0.602
G25.4 Drug-induced chorea
0.000 0.398 0.602
E34.5 Androgen resistance syndrome
0.000 0.398 0.602
E34.4 Constitutional tall stature
0.000 0.398 0.602
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.398 0.602
E34.1 Other hypersecretion of intestinal hormones
0.000 0.398 0.602
G71.0 Muscular dystrophy
0.000 0.399 0.601
C20 Malignant neoplasm of rectum
0.601 0.399 0.000
C49.3 Connective and soft tissue of thorax
0.599 0.401 0.000
E56 Other vitamin deficiencies
0.000 0.401 0.598
C51.9 Vulva, unspecified
0.598 0.402 0.000
I60-I69 Cerebrovascular diseases
0.000 0.403 0.597
G80.1 Spastic diplegia
0.000 0.403 0.597
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.404 0.596
Chapter XXII Codes for special purposes
0.000 0.404 0.596
I63 Cerebral infarction
0.000 0.405 0.595
I70 Atherosclerosis
0.000 0.405 0.595
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
0.000 0.406 0.594
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.406 0.594
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.406 0.594
C84.9 Mature T/NK-cell lymphoma, unspecified
0.593 0.407 0.000
C84.7 Anaplastic large cell lymphoma, ALK-negative
0.593 0.407 0.000
C84.6 Anaplastic large cell lymphoma, ALK-positive
0.593 0.407 0.000
C84.3 Lymphoepithelioid lymphoma
0.593 0.407 0.000
C84.2 T-zone lymphoma
0.593 0.407 0.000
C84.1 Sezary's diease
0.593 0.407 0.000
D66 Hereditary factor VIII deficiency
0.000 0.409 0.591
C76.2 Abdomen
0.591 0.409 0.000
K75.9 Inflammatory liver disease, unspecified
0.000 0.409 0.591
K75.2 Nonspecific reactive hepatitis
0.000 0.410 0.590
K75.1 Phlebitis of portal vein
0.000 0.410 0.590
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.410 0.590
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.412 0.588
C76.8 Overlapping lesion of other and ill-defined sites
0.588 0.412 0.000
C76.7 Other ill-defined sites
0.588 0.412 0.000
C76.5 Lower limb
0.588 0.412 0.000
C76.4 Upper limb
0.588 0.412 0.000
C79.6 Secondary malignant neoplasm of ovary
0.588 0.412 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.412 0.588
I20.1 Angina pectoris with documented spasm
0.000 0.413 0.587
G71.9 Primary disorder of muscle, unspecified
0.000 0.414 0.586
G71.8 Other primary disorders of muscles
0.000 0.414 0.586
G71.2 Congenital myopathies
0.000 0.414 0.586
E20.8 Other hypoparathyroidism
0.000 0.414 0.586
E20.1 Pseudohypoparathyroidism
0.000 0.414 0.586
E20.0 Idiopathic hypoparathyroidism
0.000 0.414 0.586
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.416 0.584
M06 Other rheumatoid arthritis
0.000 0.416 0.584
E14.1 With ketoacidosis
0.000 0.417 0.583
C82.3 Follicular lymphoma grade IIIa
0.582 0.418 0.000
E14.4 With neurological complications
0.000 0.418 0.582
G00-G09 Inflammatory diseases of the central nervous system
0.000 0.418 0.582
C40-C41 Malignant neoplasms of bone and articular cartilage
0.580 0.420 0.000
K90.9 Intestinal malabsorption, unspecified
0.000 0.420 0.580
I72.4 Aneurysm of artery of lower extremity
0.000 0.420 0.580
C50.5 Lower-outer quadrant of breast
0.580 0.420 0.000
D63.1 Anaemia in other chronic diseases classified elsewhere
0.000 0.421 0.579
C82.6 Cutaneous follicle centre lymphoma
0.578 0.422 0.000
C82.5 Diffuse follicle centre lymphoma
0.578 0.422 0.000
I78 Diseases of capillaries
0.000 0.423 0.577
C84.8 Cutaneous T-cell lymphoma, unspecified
0.576 0.424 0.000
G72.3 Periodic paralysis
0.000 0.425 0.575
G72.2 Myopathy due to other toxic agents
0.000 0.425 0.575
C78.5 Secondary malignant neoplasm of large intestine and rectum
0.575 0.425 0.000
E53.9 Vitamin B deficiency, unspecified
0.000 0.426 0.574
I77.8 Other specified disorders of arteries and arterioles
0.000 0.426 0.573
E61.1 Iron deficiency
0.000 0.427 0.573
E34.8 Other specified endocrine disorders
0.000 0.428 0.571
K75.8 Other specified inflammatory liver diseases
0.000 0.429 0.571
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.429 0.571
E46 Unspecified protein-energy malnutrition
0.000 0.430 0.570
I73.8 Other specified peripheral vascular diseases
0.000 0.431 0.569
C21 Malignant neoplasm of anus and anal canal
0.569 0.431 0.000
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.568 0.431 0.000
E31.9 Polyglandular dysfunction, unspecified
0.000 0.431 0.568
E31.8 Other polyglandular dysfunction
0.000 0.431 0.568
E31.1 Polyglandular hyperfunction
0.000 0.431 0.568
C90.2 Plasmacytoma, extramedullary
0.568 0.432 0.000
C77.1 Intrathoracic lymph nodes
0.567 0.433 0.000
D67 Hereditary factor IX deficiency
0.000 0.435 0.565
D73.4 Cyst of spleen
0.000 0.435 0.565
G36 Other acute disseminated demyelination
0.000 0.437 0.563
C49.1 Connective and soft tissue of upper limb, including shoulder
0.563 0.437 0.000
D73.1 Hypersplenism
0.000 0.438 0.562
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.440 0.560
L40.5 Arthropathic psoriasis
0.000 0.440 0.560
D72 Other disorders of white blood cells
0.000 0.440 0.560
C76.3 Pelvis
0.559 0.441 0.000
E16 Other disorders of pancreatic internal secretion
0.000 0.441 0.559
L40 Psoriasis
0.000 0.443 0.557
C94.4 Acute panmyelosis
0.555 0.445 0.000
E27.9 Disorder of adrenal gland, unspecified
0.000 0.447 0.553
G72.4 Inflammatory myopathy, not elsewhere classified
0.000 0.447 0.553
I99 Other and unspecified disorders of circulatory system
0.000 0.447 0.553
G72.0 Drug-induced myopathy
0.000 0.447 0.553
E54 Ascorbic acid deficiency
0.000 0.448 0.552
D80-D89 Certain disorders involving the immune mechanism
0.000 0.448 0.552
D73.9 Disease of spleen, unspecified
0.000 0.449 0.551
L40-L45 Papulosquamous disorders
0.000 0.451 0.549
E55.9 Vitamin D deficiency, unspecified
0.000 0.452 0.548
D69.9 Haemorrhagic condition, unspecified
0.000 0.454 0.546
E14.5 With peripheral circulatory complications
0.000 0.454 0.546
E14.6 With other specified complications
0.000 0.455 0.545
C82.2 Large cell, follicular
0.545 0.455 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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