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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs483574
log Bayes Factor = 26.3655
Chromosome 6   position 32,194,956  (GRCh37) Explore rs483574 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
G35 Multiple sclerosis
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.001 0.999
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.004 0.996
E10.1 With ketoacidosis
0.000 0.006 0.994
D50-D53 Nutritional anaemias
0.000 0.008 0.992
D50 Iron deficiency anaemia
0.000 0.009 0.991
L40.9 Psoriasis, unspecified
0.000 0.013 0.987
D50.9 Iron deficiency anaemia, unspecified
0.000 0.014 0.986
D51 Vitamin B12 deficiency anaemia
0.000 0.018 0.982
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.020 0.980
M06.9 Rheumatoid arthritis, unspecified
0.000 0.021 0.979
E14 Unspecified diabetes mellitus
0.000 0.022 0.978
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.023 0.977
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.023 0.977
E05.9 Thyrotoxicosis, unspecified
0.000 0.033 0.967
D80-D89 Certain disorders involving the immune mechanism
0.000 0.037 0.963
D86 Sarcoidosis
0.000 0.038 0.962
D86.9 Sarcoidosis, unspecified
0.000 0.046 0.954
E14.9 Without complications
0.000 0.055 0.945
D50.8 Other iron deficiency anaemias
0.000 0.082 0.918
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.085 0.915
E50-E64 Other nutritional deficiencies
0.000 0.085 0.915
E14.3 With ophthalmic complications
0.000 0.087 0.913
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.091 0.909
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.105 0.895
E10.4 With neurological complications
0.000 0.112 0.888
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.117 0.883
D86.1 Sarcoidosis of lymph nodes
0.000 0.137 0.863
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.140 0.860
D68 Other coagulation defects
0.000 0.142 0.858
E10.5 With peripheral circulatory complications
0.000 0.142 0.858
E10.2 With renal complications
0.000 0.144 0.856
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.000 0.154 0.846
E10.0 With coma
0.000 0.160 0.840
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.165 0.835
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.172 0.828
D86.8 Sarcoidosis of other and combined sites
0.000 0.173 0.827
E53 Deficiency of other B group vitamins
0.000 0.175 0.825
D60-D64 Aplastic and other anaemias
0.000 0.179 0.821
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.180 0.820
E55 Vitamin D deficiency
0.000 0.196 0.804
D68.0 Von Willebrand's disease
0.000 0.202 0.798
D64 Other anaemias
0.000 0.216 0.784
D53 Other nutritional anaemias
0.000 0.223 0.777
E16 Other disorders of pancreatic internal secretion
0.000 0.240 0.760
D86.0 Sarcoidosis of lung
0.000 0.241 0.759
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.242 0.758
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.243 0.757
D64.9 Anaemia, unspecified
0.000 0.254 0.746
E53.8 Deficiency of other specified B group vitamins
0.000 0.255 0.745
E10.6 With other specified complications
0.000 0.255 0.745
D52 Folate deficiency anaemia
0.000 0.260 0.740
E06 Thyroiditis
0.000 0.269 0.731
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.274 0.726
E55.9 Vitamin D deficiency, unspecified
0.000 0.276 0.724
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.284 0.716
E05.4 Thyrotoxicosis factitia
0.000 0.284 0.716
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.284 0.716
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.284 0.716
E14.4 With neurological complications
0.000 0.287 0.713
D50.1 Sideropenic dysphagia
0.000 0.289 0.711
E16.2 Hypoglycaemia, unspecified
0.000 0.290 0.710
E20-E35 Disorders of other endocrine glands
0.000 0.290 0.710
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.292 0.708
E27 Other disorders of adrenal gland
0.000 0.292 0.708
D68.9 Coagulation defect, unspecified
0.000 0.295 0.705
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.295 0.705
D66 Hereditary factor VIII deficiency
0.000 0.295 0.705
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.296 0.704
D51.2 Transcobalamin II deficiency
0.000 0.296 0.704
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.296 0.704
E27.1 Primary adrenocortical insufficiency
0.000 0.296 0.704
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.297 0.703
E14.7 With multiple complications
0.000 0.298 0.701
E14.6 With other specified complications
0.000 0.298 0.701
E14.1 With ketoacidosis
0.000 0.298 0.701
E14.0 With coma
0.000 0.298 0.701
D68.6 Other Thrombophilia
0.000 0.301 0.699
D55-D59 Haemolytic anaemias
0.000 0.302 0.698
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.304 0.696
E07 Other disorders of thyroid
0.000 0.307 0.693
D82 Immunodeficiency associated with other major defects
0.000 0.310 0.690
D81 Combined immunodeficiencies
0.000 0.310 0.690
D86.3 Sarcoidosis of skin
0.000 0.310 0.690
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.310 0.690
E10.8 With unspecified complications
0.000 0.313 0.687
D68.8 Other specified coagulation defects
0.000 0.327 0.673
E03.8 Other specified hypothyroidism
0.000 0.329 0.671
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.000 0.330 0.669
M06 Other rheumatoid arthritis
0.000 0.332 0.668
E14.8 With unspecified complications
0.000 0.334 0.665
E05.8 Other thyrotoxicosis
0.000 0.335 0.665
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.344 0.656
E63 Other nutritional deficiencies
0.000 0.344 0.656
E56 Other vitamin deficiencies
0.000 0.344 0.656
E50 Vitamin A deficiency
0.000 0.344 0.656
E60 Dietary zinc deficiency
0.000 0.344 0.656
E59 Dietary selenium deficiency
0.000 0.344 0.656
E54 Ascorbic acid deficiency
0.000 0.344 0.656
E52 Niacin deficiency [pellagra]
0.000 0.344 0.656
D61 Other aplastic anaemias
0.000 0.345 0.655
E14.5 With peripheral circulatory complications
0.000 0.345 0.654
D67 Hereditary factor IX deficiency
0.000 0.358 0.642
E53.9 Vitamin B deficiency, unspecified
0.000 0.362 0.638
D64.8 Other specified anaemias
0.000 0.368 0.632
L40 Psoriasis
0.000 0.370 0.630
E51 Thiamine deficiency
0.000 0.371 0.629
R31 Unspecified haematuria
0.629 0.371 0.000
D68.1 Hereditary factor XI deficiency
0.000 0.374 0.626
E61 Deficiency of other nutrient elements
0.000 0.376 0.624
D53.9 Nutritional anaemia, unspecified
0.000 0.377 0.623
E15 Nondiabetic hypoglycaemic coma
0.000 0.383 0.616
D68.4 Acquired coagulation factor deficiency
0.000 0.384 0.615
D83 Common variable immunodeficiency
0.000 0.386 0.613
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.387 0.613
G37 Other demyelinating diseases of central nervous system
0.000 0.402 0.598
E27.2 Addisonian crisis
0.000 0.402 0.598
E53.1 Pyridoxine deficiency
0.000 0.408 0.592
E53.0 Riboflavin deficiency
0.000 0.408 0.592
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.410 0.590
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.411 0.589
M06.3 Rheumatoid nodule
0.000 0.415 0.584
E58 Dietary calcium deficiency
0.000 0.419 0.581
E55.0 Rickets, active
0.000 0.424 0.576
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.431 0.569
D59 Acquired haemolytic anaemia
0.000 0.434 0.566
D68.5 Primary Thrombophilia
0.000 0.434 0.566
D84 Other immunodeficiencies
0.000 0.434 0.565
E07.8 Other specified disorders of thyroid
0.000 0.435 0.565
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.437 0.563
D64.4 Congenital dyserythropoietic anaemia
0.000 0.438 0.562
D64.3 Other sideroblastic anaemias
0.000 0.438 0.562
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.438 0.562
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.438 0.562
D64.0 Hereditary sideroblastic anaemia
0.000 0.438 0.562
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.439 0.561
D52.9 Folate deficiency anaemia, unspecified
0.000 0.440 0.560
D53.8 Other specified nutritional anaemias
0.000 0.443 0.557
D53.2 Scorbutic anaemia
0.000 0.443 0.557
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.443 0.557
D53.0 Protein deficiency anaemia
0.000 0.443 0.557
M06.4 Inflammatory polyarthropathy
0.000 0.444 0.556
D61.9 Aplastic anaemia, unspecified
0.000 0.451 0.549
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.454 0.546
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.455 0.545
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.455 0.545
E16.4 Abnormal secretion of gastrin
0.000 0.455 0.545
E16.3 Increased secretion of glucagon
0.000 0.455 0.545
E06.9 Thyroiditis, unspecified
0.000 0.456 0.544
E14.2 Withrenal complications
0.000 0.459 0.541
E20 Hypoparathyroidism
0.000 0.461 0.539
D52.8 Other folate deficiency anaemias
0.000 0.469 0.530
D52.1 Drug-induced folate deficiency anaemia
0.000 0.469 0.530
D52.0 Dietary folate deficiency anaemia
0.000 0.469 0.530
E27.9 Disorder of adrenal gland, unspecified
0.000 0.471 0.529
E04 Other non-toxic goitre
0.000 0.474 0.526
E06.5 Other chronic thyroiditis
0.000 0.476 0.524
E06.4 Drug-induced thyroiditis
0.000 0.476 0.524
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.476 0.524
E06.1 Subacute thyroiditis
0.000 0.476 0.524
E06.0 Acute thyroiditis
0.000 0.476 0.524
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.480 0.520
L40.0 Psoriasis vulgaris
0.000 0.482 0.518
E06.3 Autoimmune thyroiditis
0.000 0.483 0.517
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E70-E90 Metabolic disorders
0.000 0.488 0.512
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.491 0.509
E32 Diseases of thymus
0.000 0.491 0.509
E31 Polyglandular dysfunction
0.000 0.491 0.509
E30 Disorders of puberty, not elsewhere classified
0.000 0.491 0.509
E25 Adrenogenital disorders
0.000 0.491 0.509
D56 Thalassaemia
0.000 0.491 0.509
E40-E46 Malnutrition
0.001 0.491 0.508
E27.5 Adrenomedullary hyperfunction
0.000 0.492 0.508
E27.0 Other adrenocortical overactivity
0.000 0.492 0.508
G36 Other acute disseminated demyelination
0.000 0.494 0.506
E86 Volume depletion
0.000 0.495 0.505
D55 Anaemia due to enzyme disorders
0.000 0.499 0.500
E07.1 Dyshormogenetic goitre
0.000 0.503 0.497
E07.0 Hypersecretion of calcitonin
0.000 0.503 0.497
D81.9 Combined immunodeficiency, unspecified
0.000 0.505 0.495
D81.8 Other combined immunodeficiencies
0.000 0.505 0.495
D81.7 Major histocompatibility complex class II deficiency
0.000 0.505 0.495
D81.6 Major histocompatibility complex class I deficiency
0.000 0.505 0.495
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.505 0.495
D81.4 Nezelof's syndrome
0.000 0.505 0.495
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.505 0.495
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.505 0.495
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.505 0.495
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.505 0.495
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.505 0.495
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.505 0.495
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.505 0.495
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.505 0.495
D82.2 Immunodeficiency with short-limbed stature
0.000 0.505 0.495
D82.1 Di George's syndrome
0.000 0.505 0.495
D82.0 Wiskott-Aldrich syndrome
0.000 0.505 0.495
E27.8 Other specified disorders of adrenal gland
0.000 0.508 0.492
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.511 0.489
D68.2 Hereditary deficiency of other clotting factors
0.000 0.513 0.487
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.519 0.481
E13 Other specified diabetes mellitus
0.001 0.519 0.479
M06.2 Rheumatoid bursitis
0.000 0.521 0.479
M06.1 Adult-onset Still's disease
0.000 0.521 0.479
D61.1 Drug-induced aplastic anaemia
0.000 0.521 0.479
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.524 0.476
E50.9 Vitamin A deficiency, unspecified
0.000 0.530 0.470
E50.8 Other manifestations of vitamin A deficiency
0.000 0.530 0.470
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.530 0.470
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.530 0.470
E50.5 Vitamin A deficiency with night blindness
0.000 0.530 0.470
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.530 0.470
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.530 0.470
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.530 0.470
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.530 0.470
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.530 0.470
E56.9 Vitamin deficiency, unspecified
0.000 0.530 0.470
E56.8 Deficiency of other vitamins
0.000 0.530 0.470
E56.1 Deficiency of vitamin K
0.000 0.530 0.470
E56.0 Deficiency of vitamin E
0.000 0.530 0.470
E63.9 Nutritional deficiency, unspecified
0.000 0.530 0.470
E63.8 Other specified nutritional deficiencies
0.000 0.530 0.470
E63.1 Imbalance of constituents of food intake
0.000 0.530 0.470
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.530 0.470
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.530 0.470
E64.8 Sequelae of other nutritional deficiencies
0.000 0.530 0.470
E64.3 Sequelae of rickets
0.000 0.530 0.470
E64.2 Sequelae of vitamin C deficiency
0.000 0.530 0.470
E64.1 Sequelae of vitamin A deficiency
0.000 0.530 0.470
E64.0 Sequelae of protein-energy malnutrition
0.000 0.530 0.470
D61.8 Other specified aplastic anaemias
0.000 0.530 0.470
D61.3 Idiopathic aplastic anaemia
0.000 0.530 0.470
D61.2 Aplastic anaemia due to other external agents
0.000 0.530 0.470
E61.1 Iron deficiency
0.000 0.540 0.460
D59.1 Other autoimmune haemolytic anaemias
0.000 0.543 0.457
D57 Sickle-cell disorders
0.000 0.544 0.456
L40.1 Generalised pustular psoriasis
0.000 0.544 0.456
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.545 0.454
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.547 0.453
M06.34 Rheumatoid nodule (Hand)
0.000 0.547 0.452
L40.3 Pustulosis palmaris et plantaris
0.000 0.548 0.452
L40.2 Acrodermatitis continua
0.000 0.548 0.452
E51.9 Thiamine deficiency, unspecified
0.000 0.549 0.451
E51.8 Other manifestations of thiamine deficiency
0.000 0.549 0.451
E51.1 Beriberi
0.000 0.549 0.451
M06.8 Other specified rheumatoid arthritis
0.000 0.549 0.451
L40.8 Other psoriasis
0.000 0.551 0.448
E61.9 Deficiency of nutrient element, unspecified
0.000 0.552 0.447
E61.8 Deficiency of other specified nutrient elements
0.000 0.552 0.447
E61.7 Deficiency of multiple nutrient elements
0.000 0.552 0.447
E61.6 Vanadium deficiency
0.000 0.552 0.447
E61.5 Molybdenum deficiency
0.000 0.552 0.447
E61.4 Chromium deficiency
0.000 0.552 0.447
E61.3 Manganese deficiency
0.000 0.552 0.447
E61.0 Copper deficiency
0.000 0.552 0.447
E73 Lactose intolerance
0.000 0.556 0.444
D58 Other hereditary haemolytic anaemias
0.000 0.557 0.443
E34 Other endocrine disorders
0.000 0.558 0.441
E65-E68 Obesity and other hyperalimentation
0.000 0.558 0.441
D83.8 Other common variable immunodeficiencies
0.000 0.560 0.440
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.560 0.440
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.560 0.440
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.560 0.440
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.561 0.439
E04.0 Non-toxic diffuse goitre
0.000 0.561 0.439
L40.5 Arthropathic psoriasis
0.000 0.562 0.438
D61.0 Constitutional aplastic anaemia
0.000 0.562 0.437
G37.5 Concentric sclerosis [Balo]
0.000 0.571 0.429
G37.4 Subacute necrotising myelitis
0.000 0.571 0.429
G37.2 Central pontine myelinolysis
0.000 0.571 0.429
G37.1 Central demyelination of corpus callosum
0.000 0.571 0.429
G37.0 Diffuse sclerosis
0.000 0.571 0.429
D62 Acute posthaemorrhagic anaemia
0.000 0.572 0.428
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.573 0.427
E26 Hyperaldosteronism
0.000 0.574 0.426
E51.2 Wernicke's encephalopathy
0.000 0.575 0.425
D60.9 Acquired pure red cell aplasia, unspecified
0.000 0.578 0.422
D60.8 Other acquired pure red cell aplasias
0.000 0.578 0.422
D60.1 Transient acquired pure red cell aplasia
0.000 0.578 0.422
D60.0 Chronic acquired pure red cell aplasia
0.000 0.578 0.422
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.581 0.419
M06.38 Rheumatoid nodule (Other)
0.000 0.581 0.419
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.581 0.419
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.581 0.419
M06.33 Rheumatoid nodule (Forearm)
0.000 0.581 0.419
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.581 0.419
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.581 0.419
E20.9 Hypoparathyroidism, unspecified
0.000 0.584 0.416
E16.1 Other hypoglycaemia
0.000 0.593 0.407
D72 Other disorders of white blood cells
0.000 0.593 0.407
D59.8 Other acquired haemolytic anaemias
0.000 0.594 0.406
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.594 0.406
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.594 0.406
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.594 0.406
D59.3 Haemolytic-uraemic syndrome
0.000 0.594 0.406
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.594 0.406
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.594 0.406
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.594 0.406
D84.8 Other specified immunodeficiencies
0.000 0.594 0.405
D84.1 Defects in the complement system
0.000 0.594 0.405
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.594 0.405
E28 Ovarian dysfunction
0.000 0.599 0.401
E61.2 Magnesium deficiency
0.000 0.600 0.399
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.601 0.399
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.601 0.399
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.601 0.399
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.601 0.399
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.601 0.399
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.601 0.399
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.601 0.399
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.601 0.399
D80 Immunodeficiency with predominantly antibody defects
0.001 0.602 0.397
E73.9 Lactose intolerance, unspecified
0.000 0.604 0.396
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.608 0.392
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.608 0.392
D89.3 Immune reconstitution syndrome
0.000 0.608 0.392
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.608 0.392
E24 Cushing's syndrome
0.000 0.609 0.391
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.612 0.387
E20.8 Other hypoparathyroidism
0.000 0.613 0.386
E20.1 Pseudohypoparathyroidism
0.000 0.613 0.386
E20.0 Idiopathic hypoparathyroidism
0.000 0.613 0.386
L40.4 Guttate psoriasis
0.000 0.622 0.378
E04.8 Other specified non-toxic goitre
0.000 0.622 0.377
E79 Disorders of purine and pyrimidine metabolism
0.000 0.625 0.374
D56.3 Thalassaemia trait
0.000 0.626 0.374
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.626 0.374
E22 Hyperfunction of pituitary gland
0.000 0.626 0.373
E77 Disorders of glycoprotein metabolism
0.000 0.633 0.367
E76 Disorders of glycosaminoglycan metabolism
0.000 0.633 0.367
E72 Other disorders of amino-acid metabolism
0.000 0.633 0.367
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.633 0.367
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.633 0.367
D89.1 Cryoglobulinaemia
0.000 0.634 0.365
E25.9 Adrenogenital disorder, unspecified
0.000 0.635 0.365
E25.8 Other adrenogenital disorders
0.000 0.635 0.365
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.635 0.365
E30.9 Disorder of puberty, unspecified
0.000 0.635 0.365
E30.8 Other disorders of puberty
0.000 0.635 0.365
E30.1 Precocious puberty
0.000 0.635 0.365
E30.0 Delayed puberty
0.000 0.635 0.365
E31.9 Polyglandular dysfunction, unspecified
0.000 0.635 0.365
E31.8 Other polyglandular dysfunction
0.000 0.635 0.365
E31.1 Polyglandular hyperfunction
0.000 0.635 0.365
E31.0 Autoimmune polyglandular failure
0.000 0.635 0.365
E32.9 Disease of thymus, unspecified
0.000 0.635 0.365
E32.8 Other diseases of thymus
0.000 0.635 0.365
E32.1 Abscess of thymus
0.000 0.635 0.365
E32.0 Persistent hyperplasia of thymus
0.000 0.635 0.365
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.635 0.365
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.635 0.365
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.635 0.365
D56.9 Thalassaemia, unspecified
0.000 0.635 0.365
D56.8 Other thalassaemias
0.000 0.635 0.365
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.000 0.635 0.365
D56.2 Delta-beta thalassaemia
0.000 0.635 0.365
D56.1 Beta thalassaemia
0.000 0.635 0.365
D56.0 Alpha thalassaemia
0.000 0.635 0.365
E44 Protein-energy malnutrition of moderate and mild degree
0.001 0.635 0.364
E45 Retarded development following protein-energy malnutrition
0.001 0.635 0.364
E43 Unspecified severe protein-energy malnutrition
0.001 0.635 0.364
E42 Marasmic kwashiorkor
0.001 0.635 0.364
E41 Nutritional marasmus
0.001 0.635 0.364
E40 Kwashiorkor
0.001 0.635 0.364
D83.9 Common variable immunodeficiency, unspecified
0.000 0.637 0.363
G36.9 Acute disseminated demyelination, unspecified
0.000 0.637 0.363
G36.8 Other specified acute disseminated demyelination
0.000 0.637 0.363
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.637 0.363
G36.0 Neuromyelitis optica [Devic]
0.000 0.637 0.363
L40-L45 Papulosquamous disorders
0.001 0.640 0.360
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.641 0.359
D55.8 Other anaemias due to enzyme disorders
0.000 0.641 0.359
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.641 0.359
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.641 0.359
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.641 0.359
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.641 0.359
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.642 0.358
E07.9 Disorder of thyroid, unspecified
0.000 0.643 0.357
E29 Testicular dysfunction
0.000 0.644 0.356
D72.8 Other specified disorders of white blood cells
0.000 0.646 0.354
E74 Other disorders of carbohydrate metabolism
0.000 0.648 0.352
E88 Other metabolic disorders
0.000 0.652 0.348
D75 Other diseases of blood and blood-forming organs
0.000 0.653 0.347
E13.8 With unspecified complications
0.001 0.655 0.344
E13.7 With multiple complications
0.001 0.655 0.344
E13.6 With other specified complications
0.001 0.655 0.344
E13.5 With peripheral circulatory complications
0.001 0.655 0.344
E13.4 With neurological complications
0.001 0.655 0.344
E13.3 With ophthalmic complications
0.001 0.655 0.344
E13.2 With renal complications
0.001 0.655 0.344
E13.1 With ketoacidosis
0.001 0.655 0.344
E13.0 With coma
0.001 0.655 0.344
E70 Disorders of aromatic amino-acid metabolism
0.000 0.656 0.344
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.656 0.344
M06.18 Adult-onset Still's disease (Other)
0.000 0.656 0.344
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.656 0.344
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.656 0.344
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.656 0.344
M06.14 Adult-onset Still's disease (Hand)
0.000 0.656 0.344
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.656 0.344
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.656 0.344
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.656 0.344
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.656 0.344
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.656 0.344
M06.28 Rheumatoid bursitis (Other)
0.000 0.656 0.344
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.656 0.344
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.656 0.344
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.656 0.344
M06.24 Rheumatoid bursitis (Hand)
0.000 0.656 0.344
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.656 0.344
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.656 0.344
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.656 0.344
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.656 0.344
E84 Cystic fibrosis
0.000 0.657 0.342
D74 Methaemoglobinaemia
0.000 0.659 0.341
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.659 0.341
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.659 0.341
E34.0 Carcinoid syndrome
0.000 0.662 0.338
E04.2 Non-toxic multinodular goitre
0.000 0.667 0.333
E04.1 Non-toxic single thyroid nodule
0.000 0.668 0.332
E89.0 Postprocedural hypothyroidism
0.000 0.672 0.328
D57.8 Other sickle-cell disorders
0.000 0.673 0.327
D57.3 Sickle-cell trait
0.000 0.673 0.327
D57.2 Double heterozygous sickling disorders
0.000 0.673 0.327
D57.0 Sickle-cell anaemia with crisis
0.000 0.673 0.327
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.677 0.323
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.677 0.323
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.677 0.323
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.677 0.323
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.677 0.323
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.677 0.323
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.677 0.323
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.677 0.323
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.677 0.323
M06.0 Seronegative rheumatoid arthritis
0.000 0.678 0.321
E73.8 Other lactose intolerance
0.000 0.681 0.319
E73.1 Secondary lactase deficiency
0.000 0.681 0.319
E73.0 Congenital lactase deficiency
0.000 0.681 0.319
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.682 0.317
D58.2 Other haemoglobinopathies
0.000 0.682 0.317
D58.1 Hereditary elliptocytosis
0.000 0.682 0.317
E23 Hypofunction and other disorders of pituitary gland
0.000 0.683 0.317
E34.5 Androgen resistance syndrome
0.000 0.683 0.317
E34.4 Constitutional tall stature
0.000 0.683 0.317
E34.3 Short stature, not elsewhere classified
0.000 0.683 0.317
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.683 0.317
E34.1 Other hypersecretion of intestinal hormones
0.000 0.683 0.317
E67 Other hyperalimentation
0.000 0.683 0.317
E68 Sequelae of hyperalimentation
0.000 0.683 0.317
Chapter VI Diseases of the nervous system
0.000 0.687 0.313
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.688 0.312
E85 Amyloidosis
0.000 0.689 0.311
# Top node
0.000 0.694 0.306
E26.9 Hyperaldosteronism, unspecified
0.000 0.694 0.305
E26.8 Other hyperaldosteronism
0.000 0.694 0.305
E26.1 Secondary hyperaldosteronism
0.000 0.694 0.305
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.695 0.305
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.695 0.305
E34.8 Other specified endocrine disorders
0.000 0.696 0.303
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.698 0.302
G90-G99 Other disorders of the nervous system
0.000 0.698 0.302
D58.0 Hereditary spherocytosis
0.000 0.698 0.301
E22.0 Acromegaly and pituitary gigantism
0.000 0.699 0.301
D76.3 Other histiocytosis syndromes
0.000 0.699 0.301
G91 Hydrocephalus
0.000 0.701 0.299
D72.1 Eosinophilia
0.000 0.702 0.298

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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