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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs4959027
log Bayes Factor = 230.102
Chromosome 6   position 32,383,050  (GRCh37) Explore rs4959027 on Ensembl!
Variant rs4959027 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
L40 Psoriasis
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
# Top node
0.000 0.000 1.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E16.2 Hypoglycaemia, unspecified
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
I10-I15 Hypertensive diseases
0.000 0.000 1.000
Chapter IX Diseases of the circulatory system
0.000 0.000 1.000
L40-L45 Papulosquamous disorders
0.000 0.000 1.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E14.9 Without complications
0.000 0.000 1.000
E10.4 With neurological complications
0.000 0.000 1.000
M05 Seropositive rheumatoid arthritis
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
I10 Essential (primary) hypertension
0.000 0.000 1.000
E16 Other disorders of pancreatic internal secretion
0.000 0.000 1.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.000 1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.001 0.999
E11.3 With ophthalmic complications
0.000 0.001 0.999
I22 Subsequent myocardial infarction
0.000 0.001 0.999
M35.3 Polymyalgia rheumatica
0.000 0.001 0.999
E70-E90 Metabolic disorders
0.000 0.001 0.999
J33.9 Nasal polyp, unspecified
0.000 0.001 0.999
J33 Nasal polyp
0.000 0.001 0.999
E14.3 With ophthalmic complications
0.000 0.001 0.999
E10.5 With peripheral circulatory complications
0.000 0.002 0.998
H36 Retinal disorders in diseases classified elsewhere
0.000 0.002 0.998
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.003 0.997
H30-H36 Disorders of choroid and retina
0.000 0.003 0.997
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.003 0.997
G35-G37 Demyelinating diseases of the central nervous system
0.995 0.003 0.002
L40.9 Psoriasis, unspecified
0.000 0.004 0.996
Chapter VII Diseases of the eye and adnexa
0.000 0.004 0.996
M35 Other systemic involvement of connective tissue
0.000 0.006 0.994
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.006 0.994
G37 Other demyelinating diseases of central nervous system
0.993 0.006 0.000
J33.0 Polyp of nasal cavity
0.000 0.007 0.993
M20-M25 Other joint disorders
0.000 0.009 0.991
G37.9 Demyelinating disease of central nervous system, unspecified
0.991 0.009 0.000
L43 Lichen planus
0.000 0.009 0.991
J33.8 Other polyp of sinus
0.000 0.011 0.989
Chapter VIII Diseases of the ear and mastoid process
0.000 0.012 0.988
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.013 0.987
M07 Psoriatic and enteropathic arthropathies
0.000 0.014 0.986
E11.1 With ketoacidosis
0.000 0.015 0.985
I12 Hypertensive renal disease
0.000 0.015 0.985
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.017 0.983
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.018 0.982
E06 Thyroiditis
0.000 0.019 0.981
M07.3 Other psoriatic arthropathies
0.000 0.023 0.977
E10.2 With renal complications
0.000 0.023 0.977
L43.9 Lichen planus, unspecified
0.000 0.023 0.977
H60-H62 Diseases of external ear
0.000 0.024 0.976
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.025 0.975
E06.3 Autoimmune thyroiditis
0.000 0.031 0.969
I12.9 Hypertensive renal disease without renal failure
0.000 0.031 0.969
I20 Angina pectoris
0.000 0.031 0.969
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.035 0.965
H40-H42 Glaucoma
0.000 0.042 0.958
H61 Other disorders of external ear
0.000 0.045 0.955
M45-M49 Spondylopathies
0.000 0.047 0.953
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.047 0.953
M45 Ankylosing spondylitis
0.000 0.047 0.953
M06.0 Seronegative rheumatoid arthritis
0.000 0.053 0.947
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.056 0.944
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.060 0.940
E10.8 With unspecified complications
0.000 0.064 0.936
H40 Glaucoma
0.000 0.068 0.932
L57 Skin changes due to chronic exposure to nonionising radiation
0.000 0.070 0.930
H40.9 Glaucoma, unspecified
0.000 0.070 0.930
M06.3 Rheumatoid nodule
0.000 0.070 0.930
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.072 0.928
H65-H75 Diseases of middle ear and mastoid
0.000 0.076 0.924
I20.9 Angina pectoris, unspecified
0.000 0.078 0.922
E78.2 Mixed hyperlipidaemia
0.000 0.084 0.916
L57.0 Actinic keratosis
0.000 0.085 0.915
M65-M68 Disorders of synovium and tendon
0.000 0.086 0.914
H35 Other retinal disorders
0.000 0.087 0.913
H61.0 Perichondritis of external ear
0.000 0.092 0.908
M31 Other necrotising vasculopathies
0.000 0.096 0.904
H43-H45 Disorders of vitreous body and globe
0.000 0.097 0.903
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.099 0.901
H35.8 Other specified retinal disorders
0.000 0.102 0.898
M34 Systemic sclerosis
0.000 0.103 0.897
E11.5 With peripheral circulatory complications
0.000 0.104 0.896
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.106 0.894
E11.2 With renal complications
0.000 0.108 0.892
I20.0 Unstable angina
0.000 0.111 0.889
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.112 0.888
M65 Synovitis and tenosynovitis
0.000 0.117 0.883
M06.4 Inflammatory polyarthropathy
0.000 0.117 0.883
E89.0 Postprocedural hypothyroidism
0.000 0.117 0.883
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.122 0.878
H43 Disorders of vitreous body
0.000 0.123 0.877
H34 Retinal vascular occlusions
0.000 0.125 0.875
E07 Other disorders of thyroid
0.000 0.130 0.870
H60 Otitis externa
0.000 0.132 0.868
H61.8 Other specified disorders of external ear
0.000 0.137 0.863
E78.1 Pure hyperglyceridaemia
0.000 0.138 0.862
L43.8 Other lichen planus
0.000 0.140 0.860
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.141 0.859
M31.6 Other giant cell arteritis
0.000 0.142 0.858
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.143 0.857
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.144 0.856
H72 Perforation of tympanic membrane
0.000 0.144 0.856
L80-L99 Other disorders of the skin and subcutaneous tissue
0.000 0.147 0.853
H35.4 Peripheral retinal degeneration
0.000 0.150 0.850
Chapter VI Diseases of the nervous system
0.023 0.153 0.824
M65.9 Synovitis and tenosynovitis, unspecified
0.000 0.154 0.846
L97 Ulcer of lower limb, not elsewhere classified
0.000 0.157 0.843
L40.8 Other psoriasis
0.000 0.163 0.837
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.166 0.834
I20.1 Angina pectoris with documented spasm
0.000 0.168 0.832
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.168 0.832
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.169 0.831
M65.4 Radial styloid tenosynovitis [de Quervain]
0.000 0.171 0.829
I15 Secondary hypertension
0.000 0.173 0.827
M35.7 Hypermobility syndrome
0.000 0.177 0.823
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.178 0.822
E10.6 With other specified complications
0.000 0.179 0.821
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.002 0.183 0.815
G50-G59 Nerve, nerve root and plexus disorders
0.002 0.184 0.814
I25 Chronic ischaemic heart disease
0.000 0.185 0.815
M06.34 Rheumatoid nodule (Hand)
0.000 0.185 0.815
G56.0 Carpal tunnel syndrome
0.000 0.188 0.812
G37.8 Other specified demyelinating diseases of central nervous system
0.810 0.190 0.000
M35.1 Other overlap syndromes
0.000 0.191 0.809
G59 Mononeuropathy in diseases classified elsewhere
0.001 0.192 0.807
G56 Mononeuropathies of upper limb
0.000 0.192 0.807
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.805 0.195 0.000
E11.8 With unspecified complications
0.000 0.197 0.803
M65.94 Synovitis and tenosynovitis, unspecified (Hand)
0.000 0.197 0.803
G59.0 Diabetic mononeuropathy
0.000 0.197 0.803
E88 Other metabolic disorders
0.000 0.198 0.802
E78.6 Lipoprotein deficiency
0.000 0.199 0.801
E14.4 With neurological complications
0.000 0.199 0.800
H61.1 Non-infective disorders of pinna
0.000 0.201 0.799
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.202 0.798
L80 Vitiligo
0.000 0.202 0.798
I12.0 Hypertensive renal disease with renal failure
0.000 0.202 0.798
H43.8 Other disorders of vitreous body
0.000 0.204 0.796
G63 Polyneuropathy in diseases classified elsewhere
0.001 0.205 0.794
I21 Acute myocardial infarction
0.000 0.206 0.794
E11.4 With neurological complications
0.000 0.208 0.792
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.212 0.788
I24 Other acute ischaemic heart diseases
0.000 0.217 0.783
M34.1 CR(E)ST syndrome
0.000 0.217 0.783
M80-M85 Disorders of bone density and structure
0.000 0.220 0.780
H43.3 Other vitreous opacities
0.000 0.220 0.780
G63.2 Diabetic polyneuropathy
0.000 0.221 0.779
H72.0 Central perforation of tympanic membrane
0.000 0.221 0.779
L85 Other epidermal thickening
0.000 0.222 0.778
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.224 0.776
I05-I09 Chronic rheumatic heart diseases
0.000 0.225 0.775
E11.6 With other specified complications
0.000 0.225 0.775
M35.2 Behcet's disease
0.000 0.228 0.772
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.228 0.772
I25.5 Ischaemic cardiomyopathy
0.000 0.229 0.771
E03.8 Other specified hypothyroidism
0.000 0.230 0.770
E14.5 With peripheral circulatory complications
0.000 0.231 0.768
M65.43 Radial styloid tenosynovitis [de Quervain] (Forearm)
0.000 0.232 0.768
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.233 0.767
L92 Granulomatous disorders of skin and subcutaneous tissue
0.000 0.233 0.767
G61 Inflammatory polyneuropathy
0.001 0.237 0.763
I25.1 Atherosclerotic heart disease
0.000 0.237 0.763
I22.8 Subsequent myocardial infarction of other sites
0.000 0.238 0.762
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.238 0.762
E07.9 Disorder of thyroid, unspecified
0.000 0.241 0.759
M34.9 Systemic sclerosis, unspecified
0.000 0.246 0.754
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.247 0.753
L85.8 Other specified epidermal thickening
0.000 0.249 0.751
H60.3 Other infective otitis externa
0.000 0.250 0.750
H74 Other disorders of middle ear and mastoid
0.000 0.253 0.747
M30 Polyarteritis nodosa and related conditions
0.000 0.254 0.746
H66 Suppurative and unspecified otitis media
0.000 0.256 0.744
E83 Disorders of mineral metabolism
0.249 0.259 0.492
H34.8 Other retinal vascular occlusions
0.000 0.260 0.740
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.262 0.737
H40.4 Glaucoma secondary to eye inflammation
0.000 0.264 0.736
E89.2 Postprocedural hypoparathyroidism
0.000 0.265 0.735
M65.93 Synovitis and tenosynovitis, unspecified (Forearm)
0.000 0.265 0.735
M80 Osteoporosis with pathological fracture
0.000 0.266 0.734
H66.3 Other chronic suppurative otitis media
0.000 0.269 0.731
H35.2 Other proliferative retinopathy
0.000 0.271 0.729
E13 Other specified diabetes mellitus
0.000 0.272 0.728
E20-E35 Disorders of other endocrine glands
0.000 0.272 0.728
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.273 0.727
H72.9 Perforation of tympanic membrane, unspecified
0.000 0.273 0.727
H40.5 Glaucoma secondary to other eye disorders
0.000 0.276 0.724
E14.2 Withrenal complications
0.000 0.279 0.721
D64.9 Anaemia, unspecified
0.000 0.282 0.718
E16.1 Other hypoglycaemia
0.000 0.283 0.717
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.283 0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.283 0.717
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E10.0 With coma
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.6 With other specified complications
0.000 0.283 0.717
E14.1 With ketoacidosis
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.3 Pustulosis palmaris et plantaris
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
I13 Hypertensive heart and renal disease
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
L44 Other papulosquamous disorders
0.000 0.283 0.717
L41 Parapsoriasis
0.000 0.283 0.717
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
M05.8 Other seropositive rheumatoid arthritis
0.000 0.283 0.717
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.283 0.717
M05.2 Rheumatoid vasculitis
0.000 0.283 0.717
M05.1 Rheumatoid lung disease
0.000 0.283 0.717
M05.0 Felty's syndrome
0.000 0.283 0.717
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.283 0.717
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.283 0.717
E16.4 Abnormal secretion of gastrin
0.000 0.283 0.717
E16.3 Increased secretion of glucagon
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.283 0.717
E78.3 Hyperchylomicronaemia
0.000 0.283 0.716
E77 Disorders of glycoprotein metabolism
0.000 0.284 0.716
E76 Disorders of glycosaminoglycan metabolism
0.000 0.284 0.716
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.284 0.716
E70 Disorders of aromatic amino-acid metabolism
0.000 0.284 0.716
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.284 0.716
J33.1 Polypoid sinus degeneration
0.000 0.284 0.716
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.284 0.715
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.285 0.715
G36 Other acute disseminated demyelination
0.713 0.285 0.002
M82 Osteoporosis in diseases classified elsewhere
0.000 0.287 0.713
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.287 0.713
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.287 0.713
M35.5 Multifocal fibrosclerosis
0.000 0.287 0.713
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.287 0.713
M80.9 Unspecified osteoporosis with pathological fracture
0.000 0.287 0.713
G37.5 Concentric sclerosis [Balo]
0.712 0.287 0.000
G37.4 Subacute necrotising myelitis
0.712 0.287 0.000
G37.2 Central pontine myelinolysis
0.712 0.287 0.000
G37.1 Central demyelination of corpus callosum
0.712 0.287 0.000
G37.0 Diffuse sclerosis
0.712 0.287 0.000
H73 Other disorders of tympanic membrane
0.000 0.288 0.711
M65.90 Synovitis and tenosynovitis, unspecified (Multiple sites)
0.000 0.289 0.711
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.289 0.711
L43.3 Subacute (active) lichen planus
0.000 0.290 0.710
L43.2 Lichenoid drug reaction
0.000 0.290 0.710
L43.1 Bullous lichen planus
0.000 0.290 0.710
L43.0 Hypertrophic lichen planus
0.000 0.290 0.710
M49 Spondylopathies in diseases classified elsewhere
0.000 0.291 0.709
E74 Other disorders of carbohydrate metabolism
0.000 0.292 0.708
M31.3 Wegener's granulomatosis
0.000 0.293 0.707
M07.5 Arthropathy in ulcerative colitis
0.000 0.293 0.707
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.293 0.707
M07.2 Psoriatic spondylitis
0.000 0.293 0.707
M07.1 Arthritis mutilans
0.000 0.293 0.707
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.293 0.707
H60.9 Otitis externa, unspecified
0.000 0.293 0.707
H43.9 Disorder of vitreous body, unspecified
0.000 0.293 0.706
M14 Arthropathies in other diseases classified elsewhere
0.000 0.294 0.705
M65.92 Synovitis and tenosynovitis, unspecified (Upper arm)
0.000 0.295 0.705
H61.3 Acquired stenosis of external ear canal
0.000 0.295 0.705
L92.3 Foreign body granuloma of skin and subcutaneous tissue
0.000 0.296 0.704
L40.0 Psoriasis vulgaris
0.000 0.296 0.704
I21.9 Acute myocardial infarction, unspecified
0.000 0.296 0.704
E06.5 Other chronic thyroiditis
0.000 0.296 0.703
E06.4 Drug-induced thyroiditis
0.000 0.296 0.703
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.296 0.703
E06.1 Subacute thyroiditis
0.000 0.296 0.703
E06.0 Acute thyroiditis
0.000 0.296 0.703
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.298 0.702
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.298 0.702
M07.38 Other psoriatic arthropathies (Other)
0.000 0.299 0.701
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.299 0.701
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.299 0.701
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.299 0.701
H62 Disorders of external ear in diseases classified elsewhere
0.000 0.300 0.700
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.000 0.300 0.699
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.301 0.699
I00-I02 Acute rheumatic fever
0.000 0.302 0.698
D64 Other anaemias
0.000 0.305 0.695
H43.2 Crystalline deposits in vitreous body
0.000 0.307 0.693
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.307 0.693
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.309 0.690
H65 Nonsuppurative otitis media
0.000 0.310 0.690
M65.1 Other infective (teno)synovitis
0.000 0.313 0.687
H42 Glaucoma in diseases classified elsewhere
0.000 0.313 0.687
D60-D64 Aplastic and other anaemias
0.000 0.313 0.687
H60.1 Cellulitis of external ear
0.000 0.313 0.687
H30 Chorioretinal inflammation
0.000 0.315 0.685
E89.4 Postprocedural ovarian failure
0.000 0.315 0.685
L55 Sunburn
0.000 0.316 0.683
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.316 0.683
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.316 0.683
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.316 0.683
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.316 0.683
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.316 0.683
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.316 0.683
H80-H83 Diseases of inner ear
0.000 0.317 0.683
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified
0.000 0.319 0.681
H34.2 Other retinal artery occlusions
0.000 0.320 0.680
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.321 0.679
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.321 0.679
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.321 0.679
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.321 0.679
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.321 0.679
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.321 0.679
E84 Cystic fibrosis
0.000 0.321 0.679
M65.44 Radial styloid tenosynovitis [de Quervain] (Hand)
0.000 0.323 0.677
H35.6 Retinal haemorrhage
0.000 0.324 0.676
I15.1 Hypertension secondary to other renal disorders
0.000 0.326 0.674
L10-L14 Bullous disorders
0.000 0.326 0.673
E06.9 Thyroiditis, unspecified
0.000 0.327 0.673
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.331 0.669
E28 Ovarian dysfunction
0.000 0.332 0.668
H40.6 Glaucoma secondary to drugs
0.000 0.332 0.668
H40.3 Glaucoma secondary to eye trauma
0.000 0.332 0.668
I23 Certain current complications following acute myocardial infarction
0.000 0.332 0.668
E11.0 With coma
0.000 0.332 0.668
L57.5 Actinic granuloma
0.000 0.333 0.667
L57.3 Poikiloderma of Civatte
0.000 0.333 0.667
L57.2 Cutis rhomboidalis nuchae
0.000 0.333 0.667
L57.1 Actinic reticuloid
0.000 0.333 0.667
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.333 0.667
M06.38 Rheumatoid nodule (Other)
0.000 0.333 0.667
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.333 0.667
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.333 0.667
M06.33 Rheumatoid nodule (Forearm)
0.000 0.333 0.667
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.333 0.667
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.333 0.667
E40-E46 Malnutrition
0.000 0.334 0.666
L94 Other localised connective tissue disorders
0.000 0.334 0.666
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.335 0.665
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.335 0.665
E89.5 Postprocedural testicular hypofunction
0.000 0.335 0.665
E89.1 Postprocedural hypoinsulinaemia
0.000 0.335 0.665
M82.1 Osteoporosis in endocrine disorders
0.000 0.335 0.665
E79 Disorders of purine and pyrimidine metabolism
0.000 0.336 0.664
E07.8 Other specified disorders of thyroid
0.000 0.336 0.664
M12 Other specific arthropathies
0.000 0.337 0.663
L57.8 Other skin changes due to chronic exposure to nonionising radiation
0.000 0.337 0.663
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.000 0.337 0.662
H68 Eustachian salpingitis and obstruction
0.000 0.337 0.662
H67 Otitis media in diseases classified elsewhere
0.000 0.337 0.662
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)
0.000 0.340 0.660
H72.8 Other perforations of tympanic membrane
0.000 0.341 0.659
E73 Lactose intolerance
0.000 0.343 0.656
M07.6 Other enteropathic arthropathies
0.000 0.344 0.656
E72 Other disorders of amino-acid metabolism
0.000 0.344 0.655
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.000 0.345 0.655
H34.9 Retinal vascular occlusion, unspecified
0.000 0.345 0.655
H60.4 Cholesteatoma of external ear
0.000 0.345 0.655
H35.1 Retinopathy of prematurity
0.000 0.345 0.654
I15.9 Seconday hypertension, unspecified
0.000 0.346 0.654
L42 Pityriasis rosea
0.000 0.347 0.653
I24.8 Other forms of acute ischaemic heart disease
0.000 0.348 0.652
L57.4 Cutis laxa senilis
0.000 0.348 0.652
M65.95 Synovitis and tenosynovitis, unspecified (Pelvic region and thigh)
0.000 0.348 0.652
G52 Disorders of other cranial nerves
0.001 0.348 0.651
M60-M63 Disorders of muscles
0.000 0.350 0.650
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.350 0.650
M31.9 Necrotising vasculopathy, unspecified
0.000 0.351 0.649
E89.3 Postprocedural hypopituitarism
0.000 0.351 0.649
I05 Rheumatic mitral valve diseases
0.000 0.352 0.648
M31.8 Other specified necrotising vasculopathies
0.000 0.352 0.648
M31.7 Microscopic polyangiitis
0.000 0.352 0.648
M31.4 Aortic arch syndrome [Takayasu]
0.000 0.352 0.648
M31.2 Lethal midline granuloma
0.000 0.352 0.648
H60.5 Acute otitis externa, non-infective
0.000 0.352 0.648
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.352 0.648
G61.8 Other inflammatory polyneuropathies
0.000 0.354 0.646
H34.1 Central retinal artery occlusion
0.000 0.356 0.644
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.357 0.643
M34.0 Progressive systemic sclerosis
0.000 0.357 0.643
G61.9 Inflammatory polyneuropathy, unspecified
0.000 0.358 0.642
G51 Facial nerve disorders
0.001 0.358 0.641
G61.0 Guillain-Barre syndrome
0.000 0.361 0.639
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.362 0.638
G60 Hereditary and idiopathic neuropathy
0.001 0.363 0.636
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.363 0.636
L83 Acanthosis nigricans
0.000 0.364 0.636
E86 Volume depletion
0.000 0.364 0.636
M34.8 Other forms of systemic sclerosis
0.000 0.366 0.634
M65.2 Calcific tendinitis
0.000 0.366 0.633
M65.0 Abscess of tendon sheath
0.000 0.366 0.633
M66 Spontaneous rupture of synovium and tendon
0.000 0.367 0.633
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.367 0.633
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.367 0.633
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.367 0.633
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.367 0.633
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.367 0.633
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.367 0.633
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.367 0.633
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.367 0.633
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.369 0.631
G53 Cranial nerve disorders in diseases classified elsewhere
0.001 0.369 0.629
H43.0 Vitreous prolapse
0.000 0.371 0.629
H74.4 Polyp of middle ear
0.000 0.372 0.628
I09 Other rheumatic heart diseases
0.000 0.372 0.628
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.372 0.628
H34.0 Transient retinal artery occlusion
0.000 0.373 0.627
H74.0 Tympanosclerosis
0.000 0.374 0.626
E07.1 Dyshormogenetic goitre
0.000 0.376 0.624
E07.0 Hypersecretion of calcitonin
0.000 0.376 0.624
H60.2 Malignant otitis externa
0.000 0.377 0.622
L58 Radiodermatitis
0.000 0.379 0.621
E05.8 Other thyrotoxicosis
0.000 0.380 0.619
E23 Hypofunction and other disorders of pituitary gland
0.000 0.381 0.618
L92.0 Granuloma annulare
0.000 0.384 0.616
E03.1 Congenital hypothyroidism without goitre
0.000 0.386 0.614
H55-H59 Other disorders of eye and adnexa
0.000 0.387 0.613
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.388 0.612
H71 Cholesteatoma of middle ear
0.000 0.388 0.612
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere
0.000 0.388 0.611
L87 Transepidermal elimination disorders
0.000 0.388 0.611
L86 Keratoderma in diseases classified elsewhere
0.000 0.388 0.611
H72.1 Attic perforation of tympanic membrane
0.000 0.389 0.611
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)
0.000 0.389 0.611
E88.8 Other specified metabolic disorders
0.000 0.391 0.609
M65.98 Synovitis and tenosynovitis, unspecified (Other)
0.000 0.393 0.607
L56.9 Acute skin change due to ultraviolet radiation, unspecified
0.000 0.394 0.606
M11 Other crystal arthropathies
0.000 0.394 0.606
E88.2 Lipomatosis, not elsewhere classified
0.000 0.397 0.603
M10 Gout
0.000 0.398 0.602
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.400 0.600
M82.10 Osteoporosis in endocrine disorders (Multiple sites)
0.000 0.400 0.600
M15-M19 Arthrosis
0.000 0.401 0.599
M91-M94 Chondropathies
0.000 0.402 0.598
L92.9 Granulomatous disorder of skin and subcutaneous tissue, unspecified
0.000 0.403 0.597
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.404 0.596
M32 Systemic lupus erythematosus
0.000 0.405 0.595
M65.49 Radial styloid tenosynovitis [de Quervain]-Site unspec
0.000 0.406 0.594
M65.48 Radial styloid tenosynovitis [de Quervain]-Other
0.000 0.406 0.594
M65.47 Radial styloid tenosynovitis [de Quervain]-Ankle/foot
0.000 0.406 0.594
M65.46 Radial styloid tenosynovitis [de Quervain]-Lower leg
0.000 0.406 0.594
M65.45 Radial styloid tenosynovitis [de Quervain]-Pelvic/thigh
0.000 0.406 0.594
M65.42 Radial styloid tenosynovitis [de Quervain]-Upper arm
0.000 0.406 0.594
M65.41 Radial styloid tenosynovitis [de Quervain]-Shldr region
0.000 0.406 0.594
M65.40 Radial styloid tenosynovitis [de Quervain] (Multiple sites)
0.000 0.406 0.594
H61.2 Impacted cerumen
0.000 0.406 0.594
H83 Other diseases of inner ear
0.000 0.406 0.594
M31.1 Thrombotic microangiopathy
0.000 0.406 0.593
I15.8 Other secondary hypertension
0.000 0.407 0.593
I15.2 Hypertension secondary to endocrine disorders
0.000 0.407 0.593
M80.98 Unspecified osteoporosis with pathological fracture (Other)
0.000 0.407 0.593
E88.3 Tumour lysis syndrome
0.000 0.407 0.593
G56.8 Other mononeuropathies of upper limb
0.000 0.408 0.592
G56.9 Mononeuropathy of upper limb, unspecified
0.000 0.409 0.591
H69 Other disorders of Eustachian tube
0.000 0.410 0.590
H40.1 Primary open-angle glaucoma
0.000 0.410 0.590
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.411 0.589
E28.3 Primary ovarian failure
0.000 0.412 0.588
M33 Dermatopolymyositis
0.000 0.414 0.586
G64 Other disorders of peripheral nervous system
0.002 0.414 0.584
E29 Testicular dysfunction
0.000 0.414 0.586

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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