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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs510321
log Bayes Factor = 26.4361
Chromosome 6   position 32,194,392  (GRCh37) Explore rs510321 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
G35 Multiple sclerosis
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.001 0.999
E10.1 With ketoacidosis
0.000 0.005 0.995
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.006 0.994
D50 Iron deficiency anaemia
0.000 0.006 0.994
D50-D53 Nutritional anaemias
0.000 0.007 0.993
D50.9 Iron deficiency anaemia, unspecified
0.000 0.008 0.992
L40.9 Psoriasis, unspecified
0.000 0.015 0.985
E14 Unspecified diabetes mellitus
0.000 0.019 0.981
D51 Vitamin B12 deficiency anaemia
0.000 0.023 0.977
E05.9 Thyrotoxicosis, unspecified
0.000 0.029 0.971
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.030 0.970
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.031 0.969
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.034 0.966
M06.9 Rheumatoid arthritis, unspecified
0.000 0.036 0.964
E14.9 Without complications
0.000 0.052 0.948
D80-D89 Certain disorders involving the immune mechanism
0.000 0.058 0.942
D86 Sarcoidosis
0.000 0.059 0.941
D50.8 Other iron deficiency anaemias
0.000 0.066 0.934
D86.9 Sarcoidosis, unspecified
0.000 0.068 0.932
E14.3 With ophthalmic complications
0.000 0.082 0.918
E50-E64 Other nutritional deficiencies
0.000 0.094 0.906
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.099 0.901
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.104 0.895
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.113 0.887
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.113 0.887
E10.4 With neurological complications
0.000 0.116 0.884
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.000 0.136 0.864
E10.2 With renal complications
0.000 0.143 0.857
D86.1 Sarcoidosis of lymph nodes
0.000 0.150 0.850
D68 Other coagulation defects
0.000 0.151 0.849
D60-D64 Aplastic and other anaemias
0.000 0.155 0.845
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.159 0.841
E10.0 With coma
0.000 0.159 0.841
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.177 0.823
E16 Other disorders of pancreatic internal secretion
0.000 0.179 0.821
E10.5 With peripheral circulatory complications
0.000 0.182 0.818
D64 Other anaemias
0.000 0.186 0.814
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.190 0.810
E53 Deficiency of other B group vitamins
0.000 0.193 0.806
E55 Vitamin D deficiency
0.000 0.200 0.800
D68.0 Von Willebrand's disease
0.000 0.211 0.789
D86.8 Sarcoidosis of other and combined sites
0.000 0.215 0.785
E16.2 Hypoglycaemia, unspecified
0.000 0.216 0.784
D64.9 Anaemia, unspecified
0.000 0.219 0.781
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.219 0.781
D53 Other nutritional anaemias
0.000 0.222 0.778
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.241 0.759
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.246 0.754
E10.6 With other specified complications
0.000 0.254 0.746
D52 Folate deficiency anaemia
0.000 0.257 0.743
E06 Thyroiditis
0.000 0.258 0.741
E55.9 Vitamin D deficiency, unspecified
0.000 0.276 0.724
E10.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E53.8 Deficiency of other specified B group vitamins
0.000 0.283 0.717
D86.0 Sarcoidosis of lung
0.000 0.284 0.716
E05.5 Thyroid crisis or storm
0.000 0.284 0.716
E05.4 Thyrotoxicosis factitia
0.000 0.284 0.716
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.284 0.716
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.284 0.716
E14.4 With neurological complications
0.000 0.284 0.715
E20-E35 Disorders of other endocrine glands
0.000 0.286 0.714
D50.1 Sideropenic dysphagia
0.000 0.287 0.712
E27 Other disorders of adrenal gland
0.000 0.288 0.712
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.291 0.709
D66 Hereditary factor VIII deficiency
0.000 0.293 0.707
E27.1 Primary adrenocortical insufficiency
0.000 0.293 0.707
E14.7 With multiple complications
0.000 0.297 0.703
E14.6 With other specified complications
0.000 0.297 0.703
E14.1 With ketoacidosis
0.000 0.297 0.703
E14.0 With coma
0.000 0.297 0.703
D55-D59 Haemolytic anaemias
0.000 0.298 0.702
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.299 0.701
D51.2 Transcobalamin II deficiency
0.000 0.299 0.701
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.299 0.701
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.302 0.698
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.304 0.696
D68.6 Other Thrombophilia
0.000 0.308 0.692
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.309 0.691
E10.8 With unspecified complications
0.000 0.312 0.688
E14.5 With peripheral circulatory complications
0.000 0.314 0.686
D61 Other aplastic anaemias
0.000 0.316 0.684
M06 Other rheumatoid arthritis
0.000 0.319 0.681
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.324 0.676
D82 Immunodeficiency associated with other major defects
0.000 0.324 0.676
D81 Combined immunodeficiencies
0.000 0.324 0.676
D86.3 Sarcoidosis of skin
0.000 0.325 0.675
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.325 0.675
E03.8 Other specified hypothyroidism
0.000 0.327 0.673
D68.9 Coagulation defect, unspecified
0.000 0.330 0.670
D68.8 Other specified coagulation defects
0.000 0.332 0.668
E14.8 With unspecified complications
0.000 0.332 0.668
E05.8 Other thyrotoxicosis
0.000 0.334 0.665
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.000 0.337 0.663
D64.8 Other specified anaemias
0.000 0.344 0.656
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.350 0.650
E63 Other nutritional deficiencies
0.000 0.350 0.650
E56 Other vitamin deficiencies
0.000 0.350 0.650
E50 Vitamin A deficiency
0.000 0.350 0.650
E60 Dietary zinc deficiency
0.000 0.350 0.650
E59 Dietary selenium deficiency
0.000 0.350 0.650
E54 Ascorbic acid deficiency
0.000 0.350 0.650
E52 Niacin deficiency [pellagra]
0.000 0.350 0.650
E15 Nondiabetic hypoglycaemic coma
0.000 0.358 0.642
D67 Hereditary factor IX deficiency
0.000 0.364 0.636
E07 Other disorders of thyroid
0.000 0.366 0.634
L40 Psoriasis
0.000 0.369 0.631
D53.9 Nutritional anaemia, unspecified
0.000 0.375 0.625
E53.9 Vitamin B deficiency, unspecified
0.000 0.376 0.624
E51 Thiamine deficiency
0.000 0.376 0.624
D68.1 Hereditary factor XI deficiency
0.000 0.381 0.619
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.384 0.615
E61 Deficiency of other nutrient elements
0.000 0.385 0.615
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.389 0.610
R31 Unspecified haematuria
0.610 0.390 0.000
D68.4 Acquired coagulation factor deficiency
0.000 0.391 0.609
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.394 0.606
E27.2 Addisonian crisis
0.000 0.398 0.601
M06.3 Rheumatoid nodule
0.000 0.400 0.600
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.408 0.592
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.411 0.588
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.411 0.588
E16.4 Abnormal secretion of gastrin
0.000 0.411 0.588
E16.3 Increased secretion of glucagon
0.000 0.411 0.588
D64.4 Congenital dyserythropoietic anaemia
0.000 0.416 0.584
D64.3 Other sideroblastic anaemias
0.000 0.416 0.584
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.416 0.584
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.416 0.584
D64.0 Hereditary sideroblastic anaemia
0.000 0.416 0.584
E53.1 Pyridoxine deficiency
0.000 0.422 0.578
E53.0 Riboflavin deficiency
0.000 0.422 0.578
D61.9 Aplastic anaemia, unspecified
0.000 0.423 0.577
E58 Dietary calcium deficiency
0.000 0.424 0.576
D83 Common variable immunodeficiency
0.000 0.425 0.575
D59 Acquired haemolytic anaemia
0.000 0.425 0.575
M06.4 Inflammatory polyarthropathy
0.000 0.426 0.574
E55.0 Rickets, active
0.000 0.426 0.573
G37 Other demyelinating diseases of central nervous system
0.000 0.428 0.572
E04 Other non-toxic goitre
0.000 0.430 0.570
D68.5 Primary Thrombophilia
0.000 0.430 0.570
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.434 0.566
D52.9 Folate deficiency anaemia, unspecified
0.000 0.436 0.564
E06.9 Thyroiditis, unspecified
0.000 0.440 0.560
D53.8 Other specified nutritional anaemias
0.000 0.442 0.558
D53.2 Scorbutic anaemia
0.000 0.442 0.558
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.442 0.558
D53.0 Protein deficiency anaemia
0.000 0.442 0.558
E14.2 Withrenal complications
0.000 0.457 0.542
E20 Hypoparathyroidism
0.000 0.458 0.542
E70-E90 Metabolic disorders
0.000 0.464 0.536
D84 Other immunodeficiencies
0.001 0.467 0.533
D52.8 Other folate deficiency anaemias
0.000 0.467 0.533
D52.1 Drug-induced folate deficiency anaemia
0.000 0.467 0.533
D52.0 Dietary folate deficiency anaemia
0.000 0.467 0.533
E27.9 Disorder of adrenal gland, unspecified
0.000 0.467 0.533
E06.5 Other chronic thyroiditis
0.000 0.468 0.532
E06.4 Drug-induced thyroiditis
0.000 0.468 0.532
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.468 0.532
E06.1 Subacute thyroiditis
0.000 0.468 0.532
E06.0 Acute thyroiditis
0.000 0.468 0.532
E86 Volume depletion
0.000 0.469 0.531
E06.3 Autoimmune thyroiditis
0.000 0.472 0.528
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.476 0.524
L40.0 Psoriasis vulgaris
0.000 0.480 0.520
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
D56 Thalassaemia
0.000 0.488 0.512
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.488 0.512
E32 Diseases of thymus
0.000 0.488 0.512
E31 Polyglandular dysfunction
0.000 0.488 0.512
E30 Disorders of puberty, not elsewhere classified
0.000 0.488 0.512
E25 Adrenogenital disorders
0.000 0.488 0.512
E27.5 Adrenomedullary hyperfunction
0.000 0.490 0.510
E27.0 Other adrenocortical overactivity
0.000 0.490 0.510
E40-E46 Malnutrition
0.001 0.490 0.509
D61.1 Drug-induced aplastic anaemia
0.000 0.493 0.507
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.493 0.506
D55 Anaemia due to enzyme disorders
0.000 0.497 0.503
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.498 0.502
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.502 0.498
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.503 0.497
E27.8 Other specified disorders of adrenal gland
0.000 0.504 0.496
G36 Other acute disseminated demyelination
0.000 0.504 0.495
D68.2 Hereditary deficiency of other clotting factors
0.000 0.505 0.495
E07.8 Other specified disorders of thyroid
0.000 0.508 0.492
D61.8 Other specified aplastic anaemias
0.000 0.509 0.490
D61.3 Idiopathic aplastic anaemia
0.000 0.509 0.490
D61.2 Aplastic anaemia due to other external agents
0.000 0.509 0.490
M06.2 Rheumatoid bursitis
0.000 0.511 0.488
M06.1 Adult-onset Still's disease
0.000 0.511 0.488
E04.0 Non-toxic diffuse goitre
0.000 0.512 0.488
D81.9 Combined immunodeficiency, unspecified
0.000 0.515 0.484
D81.8 Other combined immunodeficiencies
0.000 0.515 0.484
D81.7 Major histocompatibility complex class II deficiency
0.000 0.515 0.484
D81.6 Major histocompatibility complex class I deficiency
0.000 0.515 0.484
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.515 0.484
D81.4 Nezelof's syndrome
0.000 0.515 0.484
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.515 0.484
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.515 0.484
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.515 0.484
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.515 0.484
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.515 0.484
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.515 0.484
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.515 0.484
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.515 0.484
D82.2 Immunodeficiency with short-limbed stature
0.000 0.515 0.484
D82.1 Di George's syndrome
0.000 0.515 0.484
D82.0 Wiskott-Aldrich syndrome
0.000 0.515 0.484
E13 Other specified diabetes mellitus
0.002 0.526 0.473
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.528 0.472
E65-E68 Obesity and other hyperalimentation
0.000 0.529 0.471
D59.1 Other autoimmune haemolytic anaemias
0.000 0.530 0.470
E50.9 Vitamin A deficiency, unspecified
0.000 0.534 0.466
E50.8 Other manifestations of vitamin A deficiency
0.000 0.534 0.466
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.534 0.466
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.534 0.466
E50.5 Vitamin A deficiency with night blindness
0.000 0.534 0.466
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.534 0.466
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.534 0.466
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.534 0.466
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.534 0.466
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.534 0.466
E56.9 Vitamin deficiency, unspecified
0.000 0.534 0.466
E56.8 Deficiency of other vitamins
0.000 0.534 0.466
E56.1 Deficiency of vitamin K
0.000 0.534 0.466
E56.0 Deficiency of vitamin E
0.000 0.534 0.466
E63.9 Nutritional deficiency, unspecified
0.000 0.534 0.466
E63.8 Other specified nutritional deficiencies
0.000 0.534 0.466
E63.1 Imbalance of constituents of food intake
0.000 0.534 0.466
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.534 0.466
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.534 0.466
E64.8 Sequelae of other nutritional deficiencies
0.000 0.534 0.466
E64.3 Sequelae of rickets
0.000 0.534 0.466
E64.2 Sequelae of vitamin C deficiency
0.000 0.534 0.466
E64.1 Sequelae of vitamin A deficiency
0.000 0.534 0.466
E64.0 Sequelae of protein-energy malnutrition
0.000 0.534 0.466
E73 Lactose intolerance
0.000 0.534 0.465
M06.34 Rheumatoid nodule (Hand)
0.000 0.535 0.465
M06.8 Other specified rheumatoid arthritis
0.000 0.540 0.459
D57 Sickle-cell disorders
0.000 0.541 0.459
L40.1 Generalised pustular psoriasis
0.000 0.543 0.457
D61.0 Constitutional aplastic anaemia
0.000 0.543 0.457
E07.1 Dyshormogenetic goitre
0.000 0.545 0.455
E07.0 Hypersecretion of calcitonin
0.000 0.545 0.455
L40.3 Pustulosis palmaris et plantaris
0.000 0.547 0.452
L40.2 Acrodermatitis continua
0.000 0.547 0.452
E61.1 Iron deficiency
0.000 0.550 0.450
L40.8 Other psoriasis
0.000 0.550 0.450
E51.9 Thiamine deficiency, unspecified
0.000 0.552 0.447
E51.8 Other manifestations of thiamine deficiency
0.000 0.552 0.447
E51.1 Beriberi
0.000 0.552 0.447
D58 Other hereditary haemolytic anaemias
0.000 0.554 0.446
E34 Other endocrine disorders
0.000 0.555 0.445
D62 Acute posthaemorrhagic anaemia
0.000 0.555 0.445
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.558 0.442
E61.9 Deficiency of nutrient element, unspecified
0.000 0.559 0.441
E61.8 Deficiency of other specified nutrient elements
0.000 0.559 0.441
E61.7 Deficiency of multiple nutrient elements
0.000 0.559 0.441
E61.6 Vanadium deficiency
0.000 0.559 0.441
E61.5 Molybdenum deficiency
0.000 0.559 0.441
E61.4 Chromium deficiency
0.000 0.559 0.441
E61.3 Manganese deficiency
0.000 0.559 0.441
E61.0 Copper deficiency
0.000 0.559 0.441
E16.1 Other hypoglycaemia
0.000 0.559 0.440
D60.9 Acquired pure red cell aplasia, unspecified
0.000 0.565 0.434
D60.8 Other acquired pure red cell aplasias
0.000 0.565 0.434
D60.1 Transient acquired pure red cell aplasia
0.000 0.565 0.434
D60.0 Chronic acquired pure red cell aplasia
0.000 0.565 0.434
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.566 0.434
L40.5 Arthropathic psoriasis
0.000 0.568 0.432
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.570 0.430
M06.38 Rheumatoid nodule (Other)
0.000 0.570 0.430
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.570 0.430
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.570 0.430
M06.33 Rheumatoid nodule (Forearm)
0.000 0.570 0.430
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.570 0.430
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.570 0.430
E26 Hyperaldosteronism
0.000 0.575 0.425
E51.2 Wernicke's encephalopathy
0.000 0.578 0.421
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.580 0.420
E20.9 Hypoparathyroidism, unspecified
0.000 0.581 0.419
E73.9 Lactose intolerance, unspecified
0.000 0.585 0.415
D83.8 Other common variable immunodeficiencies
0.000 0.587 0.412
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.587 0.412
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.587 0.412
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.587 0.412
D59.8 Other acquired haemolytic anaemias
0.000 0.588 0.412
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.588 0.412
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.588 0.412
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.588 0.412
D59.3 Haemolytic-uraemic syndrome
0.000 0.588 0.412
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.588 0.412
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.588 0.412
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.588 0.411
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.588 0.411
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.588 0.411
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.588 0.411
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.588 0.411
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.588 0.411
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.588 0.411
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.588 0.411
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.589 0.411
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.589 0.411
G37.5 Concentric sclerosis [Balo]
0.000 0.589 0.410
G37.4 Subacute necrotising myelitis
0.000 0.589 0.410
G37.2 Central pontine myelinolysis
0.000 0.589 0.410
G37.1 Central demyelination of corpus callosum
0.000 0.589 0.410
G37.0 Diffuse sclerosis
0.000 0.589 0.410
E04.8 Other specified non-toxic goitre
0.000 0.591 0.409
E28 Ovarian dysfunction
0.000 0.596 0.404
E24 Cushing's syndrome
0.000 0.605 0.395
E61.2 Magnesium deficiency
0.000 0.606 0.394
E79 Disorders of purine and pyrimidine metabolism
0.000 0.608 0.392
E20.8 Other hypoparathyroidism
0.000 0.611 0.389
E20.1 Pseudohypoparathyroidism
0.000 0.611 0.389
E20.0 Idiopathic hypoparathyroidism
0.000 0.611 0.389
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.611 0.389
E77 Disorders of glycoprotein metabolism
0.000 0.616 0.384
E76 Disorders of glycosaminoglycan metabolism
0.000 0.616 0.384
E72 Other disorders of amino-acid metabolism
0.000 0.616 0.384
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.616 0.384
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.616 0.384
D84.8 Other specified immunodeficiencies
0.001 0.617 0.382
D84.1 Defects in the complement system
0.001 0.617 0.382
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.001 0.617 0.382
E04.2 Non-toxic multinodular goitre
0.000 0.618 0.382
L40.4 Guttate psoriasis
0.000 0.621 0.379
E22 Hyperfunction of pituitary gland
0.000 0.621 0.378
E29 Testicular dysfunction
0.000 0.623 0.376
D56.3 Thalassaemia trait
0.000 0.624 0.376
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.624 0.376
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.624 0.376
D89.3 Immune reconstitution syndrome
0.000 0.624 0.376
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.624 0.376
L40-L45 Papulosquamous disorders
0.001 0.630 0.369
E74 Other disorders of carbohydrate metabolism
0.000 0.631 0.369
D56.9 Thalassaemia, unspecified
0.000 0.633 0.367
D56.8 Other thalassaemias
0.000 0.633 0.367
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.000 0.633 0.367
D56.2 Delta-beta thalassaemia
0.000 0.633 0.367
D56.1 Beta thalassaemia
0.000 0.633 0.367
D56.0 Alpha thalassaemia
0.000 0.633 0.367
E25.9 Adrenogenital disorder, unspecified
0.000 0.633 0.367
E25.8 Other adrenogenital disorders
0.000 0.633 0.367
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.633 0.367
E30.9 Disorder of puberty, unspecified
0.000 0.633 0.367
E30.8 Other disorders of puberty
0.000 0.633 0.367
E30.1 Precocious puberty
0.000 0.633 0.367
E30.0 Delayed puberty
0.000 0.633 0.367
E31.9 Polyglandular dysfunction, unspecified
0.000 0.633 0.367
E31.8 Other polyglandular dysfunction
0.000 0.633 0.367
E31.1 Polyglandular hyperfunction
0.000 0.633 0.367
E31.0 Autoimmune polyglandular failure
0.000 0.633 0.367
E32.9 Disease of thymus, unspecified
0.000 0.633 0.367
E32.8 Other diseases of thymus
0.000 0.633 0.367
E32.1 Abscess of thymus
0.000 0.633 0.367
E32.0 Persistent hyperplasia of thymus
0.000 0.633 0.367
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.633 0.367
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.633 0.367
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.633 0.367
E44 Protein-energy malnutrition of moderate and mild degree
0.001 0.634 0.365
E45 Retarded development following protein-energy malnutrition
0.001 0.634 0.365
E43 Unspecified severe protein-energy malnutrition
0.001 0.634 0.365
E42 Marasmic kwashiorkor
0.001 0.634 0.365
E41 Nutritional marasmus
0.001 0.634 0.365
E40 Kwashiorkor
0.001 0.634 0.365
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.639 0.361
D55.8 Other anaemias due to enzyme disorders
0.000 0.639 0.361
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.639 0.361
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.639 0.361
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.639 0.361
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.639 0.361
E70 Disorders of aromatic amino-acid metabolism
0.000 0.640 0.360
E88 Other metabolic disorders
0.000 0.641 0.359
E84 Cystic fibrosis
0.000 0.641 0.359
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.644 0.356
G36.9 Acute disseminated demyelination, unspecified
0.000 0.645 0.355
G36.8 Other specified acute disseminated demyelination
0.000 0.645 0.355
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.645 0.355
G36.0 Neuromyelitis optica [Devic]
0.000 0.645 0.355
D72 Other disorders of white blood cells
0.000 0.648 0.352
E04.1 Non-toxic single thyroid nodule
0.000 0.649 0.351
D89.1 Cryoglobulinaemia
0.000 0.649 0.351
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.650 0.350
M06.18 Adult-onset Still's disease (Other)
0.000 0.650 0.350
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.650 0.350
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.650 0.350
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.650 0.350
M06.14 Adult-onset Still's disease (Hand)
0.000 0.650 0.350
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.650 0.350
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.650 0.350
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.650 0.350
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.650 0.350
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.650 0.350
M06.28 Rheumatoid bursitis (Other)
0.000 0.650 0.350
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.650 0.350
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.650 0.350
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.650 0.350
M06.24 Rheumatoid bursitis (Hand)
0.000 0.650 0.350
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.650 0.350
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.650 0.350
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.650 0.350
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.650 0.350
E34.0 Carcinoid syndrome
0.000 0.658 0.341
E13.8 With unspecified complications
0.001 0.660 0.339
E13.7 With multiple complications
0.001 0.660 0.339
E13.6 With other specified complications
0.001 0.660 0.339
E13.5 With peripheral circulatory complications
0.001 0.660 0.339
E13.4 With neurological complications
0.001 0.660 0.339
E13.3 With ophthalmic complications
0.001 0.660 0.339
E13.2 With renal complications
0.001 0.660 0.339
E13.1 With ketoacidosis
0.001 0.660 0.339
E13.0 With coma
0.001 0.660 0.339
E67 Other hyperalimentation
0.000 0.662 0.338
E68 Sequelae of hyperalimentation
0.000 0.662 0.338
M06.0 Seronegative rheumatoid arthritis
0.000 0.664 0.336
E73.8 Other lactose intolerance
0.000 0.666 0.334
E73.1 Secondary lactase deficiency
0.000 0.666 0.334
E73.0 Congenital lactase deficiency
0.000 0.666 0.334
E85 Amyloidosis
0.000 0.669 0.331
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.669 0.331
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.670 0.329
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.670 0.329
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.670 0.329
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.670 0.329
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.670 0.329
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.670 0.329
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.670 0.329
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.670 0.329
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.670 0.329
D57.8 Other sickle-cell disorders
0.000 0.671 0.329
D57.3 Sickle-cell trait
0.000 0.671 0.329
D57.2 Double heterozygous sickling disorders
0.000 0.671 0.329
D57.0 Sickle-cell anaemia with crisis
0.000 0.671 0.329
Chapter VI Diseases of the nervous system
0.000 0.673 0.327
G90-G99 Other disorders of the nervous system
0.000 0.680 0.320
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.680 0.320
D58.2 Other haemoglobinopathies
0.000 0.680 0.320
D58.1 Hereditary elliptocytosis
0.000 0.680 0.320
E34.5 Androgen resistance syndrome
0.000 0.680 0.319
E34.4 Constitutional tall stature
0.000 0.680 0.319
E34.3 Short stature, not elsewhere classified
0.000 0.680 0.319
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.680 0.319
E34.1 Other hypersecretion of intestinal hormones
0.000 0.680 0.319
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.681 0.319
E89.0 Postprocedural hypothyroidism
0.000 0.681 0.319
G91 Hydrocephalus
0.000 0.682 0.318
# Top node
0.000 0.683 0.317
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.685 0.315
D83.9 Common variable immunodeficiency, unspecified
0.001 0.688 0.311
E23 Hypofunction and other disorders of pituitary gland
0.000 0.688 0.312
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.691 0.309
E34.8 Other specified endocrine disorders
0.000 0.694 0.306
E22.0 Acromegaly and pituitary gigantism
0.000 0.694 0.305
E26.9 Hyperaldosteronism, unspecified
0.000 0.695 0.305
E26.8 Other hyperaldosteronism
0.000 0.695 0.305
E26.1 Secondary hyperaldosteronism
0.000 0.695 0.305
D58.0 Hereditary spherocytosis
0.000 0.696 0.304
G91.9 Hydrocephalus, unspecified
0.000 0.696 0.304
E07.9 Disorder of thyroid, unspecified
0.000 0.697 0.303
D74 Methaemoglobinaemia
0.000 0.698 0.302
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.698 0.302
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.698 0.302
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.699 0.301
D72.8 Other specified disorders of white blood cells
0.000 0.701 0.299
D75 Other diseases of blood and blood-forming organs
0.000 0.708 0.292
E28.9 Ovarian dysfunction, unspecified
0.000 0.710 0.290
E28.8 Other ovarian dysfunction
0.000 0.710 0.290

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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