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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs61944384
log Bayes Factor = 10.148
Chromosome 12   position 111,952,215  (GRCh37) Explore rs61944384 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
I21 Acute myocardial infarction
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
I20 Angina pectoris
0.000 0.001 0.999
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.001 0.999
I25.1 Atherosclerotic heart disease
0.000 0.002 0.998
E70-E90 Metabolic disorders
0.000 0.005 0.995
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.008 0.992
I20.0 Unstable angina
0.000 0.010 0.990
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.011 0.989
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.013 0.987
E78.5 Hyperlipidaemia, unspecified
0.000 0.014 0.986
Chapter IX Diseases of the circulatory system
0.000 0.019 0.981
I30-I52 Other forms of heart disease
0.000 0.020 0.980
Z88.8 Personal history of allergy to other drugs, medicaments and biological substances
0.000 0.020 0.980
I20.9 Angina pectoris, unspecified
0.000 0.021 0.979
Z88 Personal history of allergy to drugs, medicaments and biologocal substances
0.000 0.027 0.973
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.030 0.970
E87.2 Acidosis
0.000 0.034 0.966
I45 Other conduction disorders
0.000 0.038 0.962
E83 Disorders of mineral metabolism
0.000 0.045 0.955
I25.2 Old myocardial infarction
0.000 0.049 0.951
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.052 0.948
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.052 0.948
E00-E07 Disorders of thyroid gland
0.000 0.053 0.947
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.055 0.945
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.000 0.057 0.943
Z72.0 Tobacco use
0.000 0.064 0.936
Chapter XXI Factors influencing health status and contact with health services
0.000 0.064 0.936
Z72 Problems related to lifestyle
0.000 0.066 0.934
E03 Other hypothyroidism
0.000 0.066 0.934
Z70-Z76 Persons encountering health services in other circumstances
0.000 0.066 0.934
I45.1 Other and unspecified right bundle-branch block
0.000 0.068 0.932
E83.5 Disorders of calcium metabolism
0.000 0.070 0.930
E03.9 Hypothyroidism, unspecified
0.000 0.074 0.926
Z95.8 Presence of other cardiac and vascular implants and grafts
0.000 0.077 0.923
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.083 0.917
Z88.3 Personal history of allergy to other anti-infective agents
0.000 0.084 0.916
I44 Atrioventricular and left bundle-branch block
0.000 0.086 0.914
Z83 Family history of other specific disorders
0.000 0.087 0.913
I21.9 Acute myocardial infarction, unspecified
0.000 0.089 0.911
E89.0 Postprocedural hypothyroidism
0.000 0.092 0.908
# Top node
0.000 0.093 0.907
E87.7 Fluid overload
0.000 0.096 0.904
E87.5 Hyperkalaemia
0.000 0.097 0.903
I38 Endocarditis, valve unspecified
0.000 0.100 0.900
Z95.4 Presence of other heart-valve replacement
0.000 0.102 0.898
Z83.7 Family history of diseases of the digestive system
0.000 0.106 0.894
I44.7 Left bundle-branch block, unspecified
0.000 0.107 0.893
Z88.6 Personal history of allergy to analgesic agent
0.000 0.121 0.879
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.121 0.879
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.000 0.123 0.877
Chapter V Mental and behavioural disorders
0.000 0.125 0.875
F17 Mental and behavioural disorders due to use of tobacco
0.000 0.138 0.862
F10 Mental and behavioural disorders due to use of alcohol
0.000 0.143 0.857
I20.1 Angina pectoris with documented spasm
0.000 0.153 0.847
I35 Nonrheumatic aortic valve disorders
0.000 0.162 0.838
I46 Cardiac arrest
0.000 0.162 0.838
I24 Other acute ischaemic heart diseases
0.000 0.165 0.835
I21.4 Acute subendocardial myocardial infarction
0.000 0.166 0.834
Z99 Dependence on enabling machines and devices, not elsewhere classified
0.000 0.170 0.830
Z88.4 Personal history of allergy to anaesthetic agent
0.000 0.173 0.827
F17.1 Harmful use
0.000 0.173 0.827
F10.1 Harmful use
0.000 0.179 0.821
Z74 Problems related to care-provider dependency
0.000 0.185 0.815
E20-E35 Disorders of other endocrine glands
0.000 0.192 0.808
Z97 Presence of other devices
0.000 0.196 0.804
I51 Complications and ill-defined descriptions of heart disease
0.000 0.208 0.792
E07 Other disorders of thyroid
0.000 0.211 0.789
F17.2 Dependence syndrome
0.000 0.211 0.789
I47 Paroxysmal tachycardia
0.000 0.217 0.782
I30 Acute pericarditis
0.000 0.222 0.778
I45.9 Conduction disorder, unspecified
0.000 0.222 0.778
Z99.1 Dependence on respirator
0.000 0.225 0.775
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.227 0.773
I31 Other diseases of pericardium
0.000 0.227 0.773
Z72.2 Drug use
0.000 0.227 0.773
I25.5 Ischaemic cardiomyopathy
0.000 0.230 0.770
I45.6 Preexcitation syndrome
0.000 0.232 0.768
Z40-Z54 Persons encountering health services for specific procedures and health care
0.000 0.234 0.766
E78.8 Other disorders of lipoprotein metabolism
0.000 0.238 0.762
Z88.9 Personal history of allergy to unspecified drugs, medicaments and biological substances
0.000 0.240 0.760
Z83.3 Family history of diabetes mellitus
0.000 0.244 0.756
I46.9 Cardiac arrest, unspecified
0.000 0.244 0.756
Z50 Care involving use of rehabilitation procedures
0.000 0.244 0.756
I25.3 Aneurysm of heart
0.000 0.257 0.742
I45.5 Other specified heart block
0.000 0.262 0.738
I05-I09 Chronic rheumatic heart diseases
0.000 0.264 0.736
Z50.9 Care involving use of rehabilitation procedure, unspecified
0.000 0.264 0.736
Z42 Follow-up care involving plastic surgery
0.000 0.264 0.736
Z81 Family history of mental and behavioural disorders
0.000 0.268 0.732
Z74.0 Reduced mobility
0.000 0.270 0.730
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.272 0.728
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.275 0.725
E06 Thyroiditis
0.000 0.281 0.719
E89.2 Postprocedural hypoparathyroidism
0.000 0.283 0.717
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.283 0.717
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.283 0.717
I23 Certain current complications following acute myocardial infarction
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.283 0.717
I47.2 Ventricular tachycardia
0.000 0.284 0.716
E83.1 Disorders of iron metabolism
0.000 0.285 0.715
E84 Cystic fibrosis
0.000 0.286 0.713
E79 Disorders of purine and pyrimidine metabolism
0.000 0.286 0.713
E77 Disorders of glycoprotein metabolism
0.000 0.286 0.713
E76 Disorders of glycosaminoglycan metabolism
0.000 0.286 0.713
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.286 0.713
E74 Other disorders of carbohydrate metabolism
0.000 0.286 0.713
E72 Other disorders of amino-acid metabolism
0.000 0.286 0.713
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.286 0.713
E70 Disorders of aromatic amino-acid metabolism
0.000 0.286 0.713
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.286 0.713
Z97.8 Presence of other specified devices
0.000 0.288 0.712
E87.4 Mixed disorder of acid-base balance
0.000 0.289 0.711
Z89 Acquired absence of limb
0.000 0.292 0.708
E78.6 Lipoprotein deficiency
0.000 0.292 0.708
E78.3 Hyperchylomicronaemia
0.000 0.292 0.708
E78.1 Pure hyperglyceridaemia
0.000 0.292 0.708
F10.0 Acute intoxication
0.000 0.293 0.707
Z88.7 Personal history of allergy to serum and vaccine
0.000 0.293 0.707
I00-I02 Acute rheumatic fever
0.000 0.297 0.703
I52 Other heart disorders in diseases classified elsewhere
0.000 0.297 0.703
I48 Atrial fibrillation and flutter
0.000 0.297 0.703
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.297 0.703
I41 Myocarditis in diseases classified elsewhere
0.000 0.297 0.703
I40 Acute myocarditis
0.000 0.297 0.703
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.297 0.703
I36 Nonrheumatic tricuspid valve disorders
0.000 0.297 0.703
I32 Pericarditis in diseases classified elsewhere
0.000 0.297 0.703
Z50.0 Cardiac rehabilitation
0.000 0.298 0.702
I24.8 Other forms of acute ischaemic heart disease
0.000 0.298 0.702
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.300 0.700
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.302 0.698
I37 Pulmonary valve disorders
0.000 0.303 0.697
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.306 0.694
Z50.8 Care involving use of rehabilitation procedures
0.000 0.307 0.693
Z95.3 Presence of xenogenic heart valve
0.000 0.307 0.693
E78.0 Pure hypercholesterolaemia
0.000 0.307 0.693
I45.4 Nonspecific intraventricular block
0.000 0.310 0.689
I45.2 Bifascicular block
0.000 0.310 0.689
I45.0 Right fascicular block
0.000 0.310 0.689
I35.0 Aortic (valve) stenosis
0.000 0.311 0.689
Z91 Personal history of risk-factors, not elsewhere classified
0.000 0.312 0.688
I22 Subsequent myocardial infarction
0.000 0.313 0.687
E78.4 Other hyperlipidaemia
0.000 0.315 0.685
Z42.1 Follow-up care involving plastic surgery of breast
0.000 0.315 0.685
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.315 0.685
E83.8 Other disorders of mineral metabolism
0.000 0.315 0.685
E83.2 Disorders of zinc metabolism
0.000 0.315 0.685
E83.0 Disorders of copper metabolism
0.000 0.315 0.685
F10.3 Withdrawal state
0.000 0.316 0.684
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.000 0.317 0.683
I45.3 Trifascicular block
0.000 0.318 0.682
E86 Volume depletion
0.000 0.319 0.681
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.320 0.679
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.320 0.679
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.320 0.679
E89.5 Postprocedural testicular hypofunction
0.000 0.320 0.679
E89.4 Postprocedural ovarian failure
0.000 0.320 0.679
E89.3 Postprocedural hypopituitarism
0.000 0.320 0.679
E89.1 Postprocedural hypoinsulinaemia
0.000 0.320 0.679
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.321 0.679
E00 Congenital iodine-deficiency syndrome
0.000 0.321 0.679
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.321 0.679
Z88.2 Personal history of allergy to sulphonamides
0.000 0.322 0.678
I51.7 Cardiomegaly
0.000 0.322 0.678
I35.1 Aortic (valve) insufficiency
0.000 0.322 0.678
E87.0 Hyperosmolality and hypernatraemia
0.000 0.322 0.678
I44.0 Atrioventricular block, first degree
0.000 0.322 0.678
Z84 Family history of other conditions
0.000 0.324 0.676
E07.9 Disorder of thyroid, unspecified
0.000 0.324 0.676
Z76 Persons encountering health services in other circumstances
0.000 0.325 0.675
Z72.9 Problem related to lifestyle, unspecified
0.000 0.330 0.670
Z72.8 Other problems related to lifestyle
0.000 0.330 0.670
Z72.6 Gambling and betting
0.000 0.330 0.670
Z72.5 High-risk sexual behaviour
0.000 0.330 0.670
Z72.4 Inappropriate diet and eating habits
0.000 0.330 0.670
Z72.3 Lack of physical exercise
0.000 0.330 0.670
E03.5 Myxoedema coma
0.000 0.330 0.670
E03.4 Atrophy of thyroid (acquired)
0.000 0.330 0.670
E03.3 Postinfectious hypothyroidism
0.000 0.330 0.670
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.330 0.670
E03.1 Congenital hypothyroidism without goitre
0.000 0.330 0.670
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.330 0.670
Z70 Counselling related to sexual attitude, behaviour and orientation
0.000 0.331 0.669
I44.1 Atrioventricular block, second degree
0.000 0.331 0.669
E83.3 Disorders of phosphorus metabolism
0.000 0.333 0.667
F60-F69 Disorders of adult personality and behaviour
0.000 0.340 0.660
Z42.0 Follow-up care involving plastic surgery of head and neck
0.000 0.340 0.660
I45.8 Other specified conduction disorders
0.000 0.341 0.659
I49 Other cardiac arrhythmias
0.000 0.344 0.656
I44.5 Left posterior fascicular block
0.000 0.344 0.656
I44.4 Left anterior fascicular block
0.000 0.344 0.656
Z83.6 Family history of diseases of the respiratory system
0.000 0.345 0.655
Z83.2 Family history of diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.345 0.655
Z83.1 Family history of other infectious and parasitic diseases
0.000 0.345 0.655
Z83.0 Family history of human immunodeficiency virus [HIV]
0.000 0.345 0.655
E73 Lactose intolerance
0.000 0.349 0.651
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.350 0.650
I33 Acute and subacute endocarditis
0.000 0.351 0.648
E88 Other metabolic disorders
0.000 0.353 0.647
I44.6 Other and unspecified fascicular block
0.000 0.354 0.646
Z95.2 Presence of prosthetic heart valve
0.000 0.355 0.645
E03.8 Other specified hypothyroidism
0.000 0.357 0.643
Z99.3 Dependence on wheelchair
0.000 0.358 0.642
E50-E64 Other nutritional deficiencies
0.000 0.361 0.638
E83.4 Disorders of magnesium metabolism
0.000 0.362 0.638
Z83.4 Family history of other endocrine, nutritional and metabolic diseases
0.000 0.364 0.636
I47.9 Paroxysmal tachycardia, unspecified
0.000 0.366 0.634
E87.3 Alkalosis
0.000 0.366 0.634
Z91.5 Personal history of self-harm
0.000 0.366 0.634
I07 Rheumatic tricuspid valve diseases
0.000 0.366 0.634
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.366 0.633
I30.9 Acute pericarditis, unspecified
0.000 0.368 0.632
E40-E46 Malnutrition
0.000 0.370 0.630
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances
0.000 0.371 0.629
F18 Mental and behavioural disorders due to use of volatile solvents
0.000 0.371 0.629
F16 Mental and behavioural disorders due to use of hallucinogens
0.000 0.371 0.629
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine
0.000 0.371 0.629
F14 Mental and behavioural disorders due to use of cocaine
0.000 0.371 0.629
F13 Mental and behavioural disorders due to use of sedatives or hypnotics
0.000 0.371 0.629
F12 Mental and behavioural disorders due to use of cannabinoids
0.000 0.371 0.629
F11 Mental and behavioural disorders due to use of opioids
0.000 0.371 0.629
F99-F99 Unspecified mental disorder
0.000 0.371 0.629
E23 Hypofunction and other disorders of pituitary gland
0.000 0.371 0.628
I35.8 Other aortic valve disorders
0.000 0.372 0.628
F10.2 Dependence syndrome
0.000 0.372 0.628
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.000 0.372 0.627
F70-F79 Mental retardation
0.000 0.372 0.627
Z73 Problems related to life-management difficulty
0.000 0.381 0.618
F17.9 Unspecified mental and behavioural disorder
0.000 0.382 0.618
F17.8 Other mental and behavioural disorders
0.000 0.382 0.618
F17.7 Residual and late-onset psychotic disorder
0.000 0.382 0.618
F17.6 Amnesic syndrome
0.000 0.382 0.618
F17.5 Psychotic disorder
0.000 0.382 0.618
F17.4 Withdrawal state with delirium
0.000 0.382 0.618
F17.3 Withdrawal state
0.000 0.382 0.618
F17.0 Acute intoxication
0.000 0.382 0.618
F10.4 Withdrawal state with delirium
0.000 0.383 0.617
F10.9 Unspecified mental and behavioural disorder
0.000 0.386 0.614
F10.8 Other mental and behavioural disorders
0.000 0.386 0.614
F10.7 Residual and late-onset psychotic disorder
0.000 0.386 0.614
F10.6 Amnesic syndrome
0.000 0.386 0.614
F10.5 Psychotic disorder
0.000 0.386 0.614
I25.4 Coronary artery aneurysm
0.000 0.389 0.610
Z75 Problems related to medical facilities and other health care
0.000 0.390 0.610
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.000 0.392 0.607
I51.8 Other ill-defined heart diseases
0.000 0.394 0.606
Z97.5 Presence of (intra-uterine) contraceptive device
0.000 0.394 0.605
Z72.1 Alcohol use
0.000 0.397 0.603
I46.1 Sudden cardiac death, so described
0.000 0.399 0.601
E28 Ovarian dysfunction
0.000 0.400 0.600
Z88.0 Personal history of allergy to penicillin
0.000 0.401 0.599
I24.1 Dressler's syndrome
0.000 0.401 0.599
I35.9 Aortic valve disorder, unspecified
0.000 0.403 0.597
E21.0 Primary hyperparathyroidism
0.000 0.404 0.596
I31.3 Pericardial effusion (noninflammatory)
0.000 0.404 0.596
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.404 0.595
Z99.9 Dependence on unspecified enabling machine and device
0.000 0.405 0.595
Z99.4 Dependence on artificial heart
0.000 0.405 0.595
Z99.0 Dependence on aspirator
0.000 0.405 0.595
I31.9 Disease of pericardium, unspecified
0.000 0.410 0.590
Z52 Donors of organs and tissues
0.000 0.411 0.589
Z54 Convalescence
0.000 0.411 0.589
Z97.4 Presence of external hearing-aid
0.000 0.413 0.587
Z50.7 Occupational therapy and vocational rehabilitation, not elsewhere classified
0.000 0.413 0.587
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.415 0.585
Z74.9 Problem related to care-provider dependency, unspecified
0.000 0.415 0.584
Z74.8 Other problems related to care-provider dependency
0.000 0.415 0.584
Z74.3 Need for continuous supervision
0.000 0.415 0.584
Z74.2 Need for assistance at home and no other household member able to render care
0.000 0.415 0.584
Z74.1 Need for assistance with personal care
0.000 0.415 0.584
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.000 0.416 0.584
Z81.8 Family history of other mental and behavioural disorders
0.000 0.419 0.581
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.421 0.579
E32 Diseases of thymus
0.000 0.421 0.579
E31 Polyglandular dysfunction
0.000 0.421 0.579
E30 Disorders of puberty, not elsewhere classified
0.000 0.421 0.579
E26 Hyperaldosteronism
0.000 0.421 0.579
E25 Adrenogenital disorders
0.000 0.421 0.579
E20 Hypoparathyroidism
0.000 0.421 0.579
Z97.3 Presence of spectacles and contact lenses
0.000 0.423 0.577
Z97.2 Presence of dental prosthetic device (complete)(partial)
0.000 0.423 0.577
Z97.1 Presence of artificial limb (complete)(partial)
0.000 0.423 0.577
I35.2 Aortic (valve) stenosis with insufficiency
0.000 0.425 0.574
E22 Hyperfunction of pituitary gland
0.000 0.426 0.574
E34 Other endocrine disorders
0.000 0.426 0.574
Z99.2 Dependence on renal dialysis
0.000 0.429 0.570
Z89.6 Acquired absence of leg above knee
0.000 0.430 0.570
F52 Sexual dysfunction, not caused by organic disorder or disease
0.000 0.430 0.570
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.431 0.569
I51.6 Cardiovascular disease, unspecified
0.000 0.432 0.568
I51.5 Myocardial degeneration
0.000 0.432 0.568
I51.4 Myocarditis, unspecified
0.000 0.432 0.568
I51.3 Intracardiac thrombosis, not elsewhere classified
0.000 0.432 0.568
I51.2 Rupture of papillary muscle, not elsewhere classified
0.000 0.432 0.568
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.000 0.432 0.568
I51.0 Cardiac septal defect, acquired
0.000 0.432 0.568
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.000 0.433 0.567
E07.8 Other specified disorders of thyroid
0.000 0.434 0.566
E07.1 Dyshormogenetic goitre
0.000 0.434 0.566
E07.0 Hypersecretion of calcitonin
0.000 0.434 0.566
F80-F89 Disorders of psychological development
0.000 0.435 0.565
I44.3 Other and unspecified atrioventricular block
0.000 0.438 0.562
I07.1 Tricuspid insufficiency
0.000 0.439 0.561
I30.8 Other forms of acute pericarditis
0.000 0.442 0.558
I30.1 Infective pericarditis
0.000 0.442 0.558
I30.0 Acute nonspecific idiopathic pericarditis
0.000 0.442 0.558
I99 Other and unspecified disorders of circulatory system
0.000 0.443 0.557
E24 Cushing's syndrome
0.000 0.443 0.556
I47.0 Reentry ventricular arrhythmia
0.000 0.444 0.556
E06.3 Autoimmune thyroiditis
0.000 0.444 0.556
I31.8 Other specified diseases of pericardium
0.000 0.446 0.554
I31.2 Haemopericardium, not elsewhere classified
0.000 0.446 0.554
I31.1 Chronic constrictive pericarditis
0.000 0.446 0.554
I31.0 Chronic adhesive pericarditis
0.000 0.446 0.554
E21.3 Hyperparathyroidism, unspecified
0.000 0.446 0.554
Chapter XXII Codes for special purposes
0.000 0.446 0.553
Z88.1 Personal history of allergy to other antibiotic agents
0.000 0.448 0.552
E29 Testicular dysfunction
0.000 0.451 0.549
Z50.4 Psychotherapy, not elsewhere classified
0.000 0.451 0.549
E16 Other disorders of pancreatic internal secretion
0.000 0.451 0.548
Z89.5 Acquired absence of leg at or below knee
0.000 0.455 0.545
Chapter VIII Diseases of the ear and mastoid process
0.000 0.456 0.544
Z49 Care involving dialysis
0.000 0.458 0.542
Z50.6 Orthoptic training
0.000 0.458 0.542
Z50.3 Drug rehabilitation
0.000 0.458 0.542
I46.0 Cardiac arrest with successful resuscitation
0.000 0.458 0.542
S00-S09 Injuries to the head
0.000 0.459 0.541
Z40 Prophylactic surgery
0.000 0.459 0.541
S50-S59 Injuries to the elbow and forearm
0.000 0.461 0.539
E27 Other disorders of adrenal gland
0.000 0.463 0.537
E23.0 Hypopituitarism
0.000 0.463 0.537
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.463 0.537
I60-I69 Cerebrovascular diseases
0.000 0.464 0.536
F60 Specific personality disorders
0.000 0.469 0.531
Z50.2 Alcohol rehabilitation
0.000 0.470 0.530
Z41 Procedures for purposes other than remedying health state
0.000 0.471 0.529
I09 Other rheumatic heart diseases
0.000 0.472 0.528
I06 Rheumatic aortic valve diseases
0.000 0.472 0.528
S70-S79 Injuries to the hip and thigh
0.000 0.472 0.528
Z42.9 Follow-up care involving plastic surgery, unspecified
0.000 0.472 0.527
Z42.8 Follow-up care involving plastic surgery of other body part
0.000 0.472 0.527
Z42.4 Follow-up care involving plastic surgery of lower extremity
0.000 0.472 0.527
Z42.3 Follow-up care involving plastic surgery of upper extremity
0.000 0.472 0.527
Z53 Persons encountering health services for specifie procedures, not carried out
0.000 0.473 0.527
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.474 0.526
F00-F09 Organic, including symptomatic, mental disorders
0.000 0.474 0.526
Z44 Fitting and adjustment of external prosthetic device
0.000 0.475 0.525
Z81.4 Family history of other substance abuse
0.000 0.475 0.525
Z81.3 Family history of other psychoactive substance abuse
0.000 0.475 0.525
Z81.2 Family history of tobacco abuse
0.000 0.475 0.525
Z81.1 Family history of alcohol abuse
0.000 0.475 0.525
Z81.0 Family history of mental retardation
0.000 0.475 0.525
E87.6 Hypokalaemia
0.000 0.477 0.523
E05.8 Other thyrotoxicosis
0.000 0.478 0.522
E05.5 Thyroid crisis or storm
0.000 0.478 0.522
E05.4 Thyrotoxicosis factitia
0.000 0.478 0.522
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.478 0.522
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.478 0.522
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.478 0.522
I08 Multiple valve diseases
0.000 0.478 0.522
I49.8 Other specified cardiac arrhythmias
0.000 0.478 0.522
E55 Vitamin D deficiency
0.000 0.478 0.521
E85 Amyloidosis
0.001 0.479 0.521
E15 Nondiabetic hypoglycaemic coma
0.000 0.480 0.519
E06.9 Thyroiditis, unspecified
0.000 0.484 0.516
E06.5 Other chronic thyroiditis
0.000 0.484 0.516
E06.4 Drug-induced thyroiditis
0.000 0.484 0.516
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.484 0.516
E06.1 Subacute thyroiditis
0.000 0.484 0.516
E06.0 Acute thyroiditis
0.000 0.484 0.516
I23.8 Other current complications following acute myocardial infarction
0.000 0.486 0.514
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.486 0.514
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.486 0.514
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.486 0.514
S20-S29 Injuries to the thorax
0.000 0.488 0.512
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.488 0.511
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.488 0.511
E70.3 Albinism
0.000 0.488 0.511
E70.2 Disorders of tyrosine metabolism
0.000 0.488 0.511
E70.1 Other hyperphenylalaninaemias
0.000 0.488 0.511
E70.0 Classical phenylketonuria
0.000 0.488 0.511
E71.3 Disorders of fatty-acid metabolism
0.000 0.488 0.511
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.488 0.511
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.488 0.511
E71.0 Maple-syrup-urine disease
0.000 0.488 0.511
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.488 0.511
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.488 0.511
E72.5 Disorders of glycine metabolism
0.000 0.488 0.511
E72.4 Disorders of ornithine metabolism
0.000 0.488 0.511
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.488 0.511
E72.2 Disorders of urea cycle metabolism
0.000 0.488 0.511
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.488 0.511
E72.0 Disorders of amino-acid transport
0.000 0.488 0.511
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.488 0.511
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.488 0.511
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.488 0.511
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.488 0.511
E74.2 Disorders of galactose metabolism
0.000 0.488 0.511
E74.1 Disorders of fructose metabolism
0.000 0.488 0.511
E74.0 Glycogen storage disease
0.000 0.488 0.511
E75.6 Lipid storage disorder, unspecified
0.000 0.488 0.511
E75.5 Other lipid storage disorders
0.000 0.488 0.511
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.488 0.511
E75.3 Sphingolipidosis, unspecified
0.000 0.488 0.511
E75.2 Other sphingolipidosis
0.000 0.488 0.511
E75.1 Other gangliosidosis
0.000 0.488 0.511
E75.0 GM2 gangliosidosis
0.000 0.488 0.511
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.488 0.511
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.488 0.511
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.488 0.511
E76.2 Other mucopolysaccharidoses
0.000 0.488 0.511
E76.1 Mucopolysaccharidosis, type II
0.000 0.488 0.511
E76.0 Mucopolysaccharidosis, type I
0.000 0.488 0.511
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.488 0.511
E77.8 Other disorders of glycoprotein metabolism
0.000 0.488 0.511
E77.1 Defects in glycoprotein degradation
0.000 0.488 0.511
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.488 0.511
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.488 0.511
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.488 0.511
E79.1 Lesch-Nyhan syndrome
0.000 0.488 0.511
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.488 0.511
E84.9 Cystic fibrosis, unspecified
0.000 0.488 0.511
E84.8 Cystic fibrosis with other manifestations
0.000 0.488 0.511
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.488 0.511
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.488 0.511
S72 Fracture of femur
0.000 0.491 0.509
Z97.0 Presence of artificial eye
0.000 0.491 0.509
Z89.9 Acquired absence of limb, unspecified
0.000 0.492 0.508
Z89.8 Acquired absence of upper and lower limbs [any level]
0.000 0.492 0.508
Z89.7 Acquired absence of both lower limbs [any level, except toes alone]
0.000 0.492 0.508
Z89.3 Acquired absence of both upper limbs [any level]
0.000 0.492 0.508
Z89.2 Acquired absence of upper limb above wrist
0.000 0.492 0.508
Z89.1 Acquired absence of hand and wrist
0.000 0.492 0.508
Z89.0 Acquired absence of finger(s) [including thumb], unilateral
0.000 0.492 0.508
I50 Heart failure
0.000 0.493 0.507
I02 Rheumatic chorea
0.000 0.496 0.504
I01 Rheumatic fever with heart involvement
0.000 0.496 0.504
I00 Rheumatic fever without mention of heart involvement
0.000 0.496 0.504
I32.8 Pericarditis in other diseases classified elsewhere
0.000 0.496 0.504
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.496 0.504
I32.0 Pericarditis in bacterial diseases classified elsewhere
0.000 0.496 0.504
I36.9 Nonrheumatic tricuspid valve disorder, unspecified
0.000 0.496 0.504
I36.8 Other nonrheumatic tricuspid valve disorders
0.000 0.496 0.504
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency
0.000 0.496 0.504
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.000 0.496 0.504
I36.0 Nonrheumatic tricuspid (valve) stenosis
0.000 0.496 0.504
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere
0.000 0.496 0.504
I39.4 Multiple valve disorders in diseases classified elsewhere
0.000 0.496 0.504
I39.3 Pulmonary valve disorders in diseases classified elsewhere
0.000 0.496 0.504
I39.2 Tricuspid valve disorders in diseases classified elsewhere
0.000 0.496 0.504
I39.1 Aortic valve disorders in diseases classified elsewhere
0.000 0.496 0.504
I39.0 Mitral valve disorders in diseases classified elsewhere
0.000 0.496 0.504
I40.9 Acute myocarditis, unspecified
0.000 0.496 0.504
I40.8 Other acute myocarditis
0.000 0.496 0.504
I40.1 Isolated myocarditis
0.000 0.496 0.504
I40.0 Infective myocarditis
0.000 0.496 0.504
I41.8 Myocarditis in other diseases classified elsewhere
0.000 0.496 0.504
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.496 0.504
I41.1 Myocarditis in viral diseases classified elsewhere
0.000 0.496 0.504
I41.0 Myocarditis in bacterial diseases classified elsewhere
0.000 0.496 0.504
I43.8 Cardiomyopathy in other diseases classified elsewhere
0.000 0.496 0.504
I43.2 Cardiomyopathy in nutritional diseases
0.000 0.496 0.504
I43.1 Cardiomyopathy in metabolic diseases
0.000 0.496 0.504
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere
0.000 0.496 0.504
I48.9 Atrial fibrillation and atrial flutter, unspecified
0.000 0.496 0.504
I48.4 Atypical atrial flutter
0.000 0.496 0.504
I48.3 Typical atrial flutter
0.000 0.496 0.504
I48.2 Chronic atrial fibrillation
0.000 0.496 0.504
I48.1 Persistent atrial fibrillation
0.000 0.496 0.504
I48.0 Paroxysmal atrial fibrillation
0.000 0.496 0.504
I52.8 Other heart disorders in other diseases classified elsewhere
0.000 0.496 0.504
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.496 0.504
I52.0 Other heart disorders in bacterial diseases classified elsewhere
0.000 0.496 0.504
S52 Fracture of forearm
0.000 0.497 0.503
Z95.0 Presence of cardiac pacemaker
0.000 0.497 0.503
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.498 0.502
E21.4 Other specified disorders of parathyroid gland
0.000 0.498 0.502
E21.2 Other hyperparathyroidism
0.000 0.498 0.502
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.498 0.502
E05.9 Thyrotoxicosis, unspecified
0.000 0.498 0.502
E65-E68 Obesity and other hyperalimentation
0.000 0.499 0.501
I49.1 Atrial premature depolarisation
0.000 0.500 0.500
I37.9 Pulmonary valve disorder, unspecified
0.000 0.500 0.500
I37.8 Other pulmonary valve disorders
0.000 0.500 0.500
I37.2 Pulmonary valve stenosis with insufficiency
0.000 0.500 0.500
I37.0 Pulmonary valve stenosis
0.000 0.500 0.500
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.500 0.500
I49.0 Ventricular fibrillation and flutter
0.000 0.502 0.498
I98 Other disorders of circulatory system in diseases classified elsewhere
0.000 0.504 0.496
I37.1 Pulmonary valve insufficiency
0.000 0.506 0.494
Z53.2 Procedure not carried out because of patient's decision for other and unspecified reasons
0.000 0.506 0.494
Z91.7 Personal history of female genital mutilation
0.000 0.506 0.493
Z91.4 Personal history of psychological trauma, not elsewhere classified
0.000 0.506 0.493

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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