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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs62235665
log Bayes Factor = 13.4781
Chromosome 21   position 41,534,335  (GRCh37) Explore rs62235665 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter XX External causes of morbidity and mortality
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
Chapter V Mental and behavioural disorders
1.000 0.000 0.000
J40-J47 Chronic lower respiratory diseases
1.000 0.000 0.000
J44 Other chronic obstructive pulmonary disease
1.000 0.000 0.000
I30-I52 Other forms of heart disease
1.000 0.000 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.998 0.002 0.000
J44.9 Chronic obstructive pulmonary disease, unspecified
0.998 0.002 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.998 0.002 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.998 0.002 0.000
F10 Mental and behavioural disorders due to use of alcohol
0.997 0.003 0.000
Chapter X Diseases of the respiratory system
0.995 0.005 0.000
Y83.1 Surgical operation with implant of artificial internal device
0.994 0.006 0.000
J40 Bronchitis, not specified as acute or chronic
0.994 0.006 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.994 0.006 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.990 0.010 0.000
I45 Other conduction disorders
0.986 0.014 0.000
F30-F39 Mood [affective] disorders
0.983 0.017 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.983 0.017 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.982 0.018 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.980 0.020 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.978 0.022 0.000
I51 Complications and ill-defined descriptions of heart disease
0.973 0.027 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.971 0.029 0.000
I20-I25 Ischaemic heart diseases
0.971 0.029 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.967 0.033 0.000
V20-V29 Motorcycle rider injured in transport accident
0.965 0.035 0.000
F10.0 Acute intoxication
0.963 0.037 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.962 0.038 0.000
T51 Toxic effect of alcohol
0.953 0.047 0.000
I21 Acute myocardial infarction
0.948 0.052 0.000
I34 Nonrheumatic mitral valve disorders
0.948 0.052 0.000
I05-I09 Chronic rheumatic heart diseases
0.942 0.058 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.939 0.061 0.000
I21.9 Acute myocardial infarction, unspecified
0.936 0.064 0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts
0.935 0.065 0.000
T39.1 4-Aminophenol derivatives
0.933 0.067 0.000
V23 Motorcycle rider injured in collision with car, pick-up truck or van
0.930 0.070 0.000
F31 Bipolar affective disorder
0.930 0.070 0.000
Chapter VIII Diseases of the ear and mastoid process
0.928 0.072 0.000
I51.8 Other ill-defined heart diseases
0.927 0.073 0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts
0.923 0.077 0.000
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.921 0.079 0.000
T43.2 Other and unspecified antidepressants
0.920 0.080 0.000
I45.1 Other and unspecified right bundle-branch block
0.920 0.080 0.000
F10.1 Harmful use
0.918 0.082 0.000
T51.0 Ethanol
0.910 0.090 0.000
F10.2 Dependence syndrome
0.906 0.094 0.000
V23.4 Driver injured in traffic accident
0.905 0.095 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.904 0.096 0.000
Q60-Q64 Congenital malformations of the urinary system
0.902 0.098 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.894 0.106 0.000
I34.0 Mitral (valve) insufficiency
0.893 0.107 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.890 0.110 0.000
Chapter VI Diseases of the nervous system
0.875 0.125 0.000
X20-X29 Contact with venomous animals and plants
0.874 0.126 0.000
J42 Unspecified chronic bronchitis
0.871 0.129 0.000
G40-G47 Episodic and paroxysmal disorders
0.870 0.130 0.000
S10-S19 Injuries to the neck
0.868 0.132 0.000
F10.4 Withdrawal state with delirium
0.863 0.137 0.000
F33 Recurrent depressive disorder
0.862 0.138 0.000
I42 Cardiomyopathy
0.858 0.142 0.000
G45 Transient cerebral ischaemic attacks and related syndromes
0.857 0.143 0.000
I51.7 Cardiomegaly
0.854 0.146 0.000
H80-H83 Diseases of inner ear
0.852 0.148 0.000
I45.9 Conduction disorder, unspecified
0.852 0.148 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.851 0.149 0.000
G45.9 Transient cerebral ischaemic attack, unspecified
0.851 0.149 0.000
I08 Multiple valve diseases
0.850 0.150 0.000
S80-S89 Injuries to the knee and lower leg
0.846 0.154 0.000
I71 Aortic aneurysm and dissection
0.844 0.156 0.000
T86 Failure and rejection of transplanted organs and tissues
0.842 0.158 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.842 0.158 0.000
I46 Cardiac arrest
0.841 0.159 0.000
I50 Heart failure
0.840 0.160 0.000
H65-H75 Diseases of middle ear and mastoid
0.838 0.162 0.000
F31.3 Bipolar affective disorder, current episode mild or moderate depression
0.836 0.164 0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants
0.835 0.165 0.000
X60-X84 Intentional self-harm
0.832 0.168 0.000
Y48 Anaesthetics and therapeutic gases
0.827 0.173 0.000
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.826 0.174 0.000
I73 Other peripheral vascular diseases
0.823 0.176 0.000
Chapter II Neoplasms
0.820 0.180 0.000
T84.1 Mechanical complication of internal fixation device of bones of limb
0.819 0.181 0.000
I45.2 Bifascicular block
0.818 0.182 0.000
T51.9 Alcohol, unspecified
0.817 0.183 0.000
H81 Disorders of vestibular function
0.815 0.185 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.815 0.185 0.000
I07 Rheumatic tricuspid valve diseases
0.814 0.186 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.813 0.187 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.812 0.188 0.000
S90-S99 Injuries to the ankle and foot
0.812 0.188 0.000
D00-D09 In situ neoplasms
0.811 0.189 0.000
J44.8 Other specified chronic obstructive pulmonary disease
0.809 0.191 0.000
T58 Toxic effect of carbon monoxide
0.809 0.191 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.808 0.192 0.000
F32 Depressive episode
0.807 0.193 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.806 0.194 0.000
J47 Bronchiectasis
0.806 0.194 0.000
V10-V19 Pedal cyclist injured in transport accident
0.806 0.194 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.805 0.195 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.805 0.195 0.000
Y45.1 Salicylates
0.803 0.197 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.803 0.197 0.000
F80-F89 Disorders of psychological development
0.803 0.197 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.799 0.201 0.000
I22 Subsequent myocardial infarction
0.798 0.202 0.000
J43 Emphysema
0.796 0.204 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.794 0.206 0.000
T63 Toxic effect of contact with venomous animals
0.793 0.207 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.792 0.208 0.000
I45.4 Nonspecific intraventricular block
0.791 0.209 0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts
0.790 0.210 0.000
I70 Atherosclerosis
0.789 0.211 0.000
D05 Carcinoma in situ of breast
0.789 0.211 0.000
F10.3 Withdrawal state
0.789 0.211 0.000
J46 Status asthmaticus
0.788 0.211 0.000
I30 Acute pericarditis
0.787 0.213 0.000
J95-J99 Other diseases of the respiratory system
0.787 0.213 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.786 0.214 0.000
I45.6 Preexcitation syndrome
0.785 0.215 0.000
F11 Mental and behavioural disorders due to use of opioids
0.783 0.216 0.000
X23 Contact with hornets, wasps and bees
0.783 0.217 0.000
I36 Nonrheumatic tricuspid valve disorders
0.779 0.221 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.777 0.223 0.000
I51.0 Cardiac septal defect, acquired
0.776 0.224 0.000
G40 Epilepsy
0.776 0.224 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.776 0.224 0.000
I45.8 Other specified conduction disorders
0.775 0.225 0.000
V28 Motorcycle rider injured in noncollision transport accident
0.775 0.225 0.000
Q60 Renal agenesis and other reduction defects of kidney
0.775 0.225 0.000
T82.4 Mechanical complication of vascular dialysis catheter
0.774 0.226 0.000
D05.1 Intraductal carcinoma in situ
0.773 0.227 0.000
Q80-Q89 Other congenital malformations
0.772 0.228 0.000
T82.3 Mechanical complication of other vascular grafts
0.770 0.230 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.769 0.231 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.768 0.232 0.000
F10.5 Psychotic disorder
0.766 0.234 0.000
F30 Manic episode
0.764 0.235 0.000
I31 Other diseases of pericardium
0.764 0.236 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.764 0.236 0.000
S50-S59 Injuries to the elbow and forearm
0.763 0.237 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.761 0.239 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.761 0.239 0.000
V40-V49 Car occupant injured in transport accident
0.760 0.240 0.000
I20 Angina pectoris
0.760 0.240 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.758 0.242 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.758 0.242 0.000
Y00-Y09 Assault
0.757 0.243 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.753 0.247 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.753 0.247 0.000
I74 Arterial embolism and thrombosis
0.752 0.248 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.749 0.250 0.000
F33.2 Recurrent depressive disorder, current episode severe without psychotic symptoms
0.749 0.251 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.748 0.252 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.748 0.252 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.747 0.253 0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.746 0.254 0.000
S12 Fracture of neck
0.745 0.255 0.000
D03 Melanoma in situ
0.745 0.255 0.000
I50.1 Left ventricular failure
0.744 0.256 0.000
T79-T79 Certain early complications of trauma
0.743 0.257 0.000
F31.6 Bipolar affective disorder, current episode mixed
0.743 0.257 0.000
Q61 Cystic kidney disease
0.740 0.260 0.000
T56 Toxic effect of metals
0.740 0.260 0.000
Y83.0 Surgical operation with transplant of whole organ
0.739 0.261 0.000
V80-V89 Other land transport accidents
0.738 0.261 0.000
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.738 0.262 0.000
C50-C50 Malignant neoplasm of breast
0.738 0.262 0.000
S89 Other and unspecified injuries of lower leg
0.734 0.266 0.000
F12 Mental and behavioural disorders due to use of cannabinoids
0.733 0.267 0.000
H81.2 Vestibular neuronitis
0.732 0.268 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.731 0.269 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.729 0.270 0.000
Q63 Other congenital malformations of kidney
0.729 0.271 0.000
I73.9 Peripheral vascular disease, unspecified
0.729 0.271 0.000
F31.0 Bipolar affective disorder, current episode hypomanic
0.728 0.272 0.000
H71 Cholesteatoma of middle ear
0.727 0.273 0.000
Y40 Systemic antibiotics
0.727 0.273 0.000
I46.0 Cardiac arrest with successful resuscitation
0.727 0.273 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.726 0.274 0.000
I72 Other aneurysm
0.726 0.274 0.000
F60-F69 Disorders of adult personality and behaviour
0.725 0.275 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.725 0.275 0.000
T00-T07 Injuries involving multiple body regions
0.724 0.276 0.000
T39.0 Salicylates
0.724 0.276 0.000
G40.9 Epilepsy, unspecified
0.723 0.277 0.000
Y83.9 Surgical procedure, unspecified
0.723 0.277 0.000
I07.1 Tricuspid insufficiency
0.722 0.277 0.000
I21.4 Acute subendocardial myocardial infarction
0.721 0.279 0.000
J20-J22 Other acute lower respiratory infections
0.721 0.279 0.000
Y45.0 Opioids and related analgesics
0.720 0.280 0.000
I08.1 Disorders of both mitral and tricuspid valves
0.719 0.281 0.000
X23.9 Unspecified place
0.719 0.281 0.000
T87 Complications peculiar to reattachment and amputation
0.718 0.282 0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.718 0.282 0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts
0.717 0.283 0.000
Z95 Presence of cardiac and vascular implants and grafts
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
Y35-Y36 Legal intervention and operations of war
0.717 0.283 0.000
Y10-Y34 Event of undetermined intent
0.717 0.283 0.000
X85-X99 Assault
0.717 0.283 0.000
X30-X39 Exposure to forces of nature
0.717 0.283 0.000
X10-X19 Contact with heat and hot substances
0.717 0.283 0.000
X00-X09 Exposure to smoke, fire and flames
0.717 0.283 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.717 0.283 0.000
W75-W84 Other accidental threats to breathing
0.717 0.283 0.000
W65-W74 Accidental drowning and submersion
0.717 0.283 0.000
V98-V99 Other and unspecified transport accidents
0.717 0.283 0.000
V95-V97 Air and space transport accidents
0.717 0.283 0.000
V90-V94 Water transport accidents
0.717 0.283 0.000
V70-V79 Bus occupant injured in transport accident
0.717 0.283 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.717 0.283 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.717 0.283 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.717 0.283 0.000
V01-V09 Pedestrian injured in transport accident
0.717 0.283 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.717 0.283 0.000
F70-F79 Mental retardation
0.717 0.283 0.000
J41 Simple and mucopurulent chronic bronchitis
0.717 0.283 0.000
I52 Other heart disorders in diseases classified elsewhere
0.717 0.283 0.000
I48 Atrial fibrillation and flutter
0.717 0.283 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.717 0.283 0.000
I41 Myocarditis in diseases classified elsewhere
0.717 0.283 0.000
I40 Acute myocarditis
0.717 0.283 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.717 0.283 0.000
I32 Pericarditis in diseases classified elsewhere
0.717 0.283 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.716 0.284 0.000
Z95.5 Presence of coronary angioplasty implant and graft
0.716 0.284 0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances
0.716 0.284 0.000
F18 Mental and behavioural disorders due to use of volatile solvents
0.716 0.284 0.000
F16 Mental and behavioural disorders due to use of hallucinogens
0.716 0.284 0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine
0.716 0.284 0.000
F14 Mental and behavioural disorders due to use of cocaine
0.716 0.284 0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics
0.716 0.284 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.716 0.284 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.716 0.284 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.716 0.284 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.716 0.284 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.716 0.284 0.000
T36 Poisoning by systemic antibiotics
0.716 0.284 0.000
F10.9 Unspecified mental and behavioural disorder
0.715 0.285 0.000
F10.8 Other mental and behavioural disorders
0.715 0.285 0.000
F10.7 Residual and late-onset psychotic disorder
0.715 0.285 0.000
F10.6 Amnesic syndrome
0.715 0.285 0.000
Q00-Q07 Congenital malformations of the nervous system
0.714 0.285 0.000
T88.6 Anaphylactic shock due to adverse effect of correct drug or medicament properly administered
0.713 0.287 0.000
W50-W64 Exposure to animate mechanical forces
0.713 0.287 0.000
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms
0.712 0.288 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.710 0.290 0.000
F43 Reaction to severe stress, and adjustment disorders
0.710 0.290 0.000
Chapter XXI Factors influencing health status and contact with health services
0.709 0.291 0.000
T42.4 Benzodiazepines
0.708 0.292 0.000
I45.0 Right fascicular block
0.707 0.293 0.000
I71.0 Dissection of aorta [any part]
0.706 0.294 0.000
T88.8 Other specified complications of surgical and medical care, not elsewhere classified
0.706 0.294 0.000
I20.8 Other forms of angina pectoris
0.706 0.294 0.000
F38 Other mood [affective] disorders
0.705 0.295 0.000
F34 Persistent mood [affective] disorders
0.705 0.295 0.000
F39 Unspecified mood [affective] disorder
0.705 0.295 0.000
T65 Toxic effect of other and unspecified substances
0.705 0.295 0.000
T62 Toxic effect of other noxious substances eaten as food
0.705 0.295 0.000
T61 Toxic effect of noxious substances eaten as seafood
0.705 0.295 0.000
T60 Toxic effect of pesticides
0.705 0.295 0.000
T57 Toxic effect of other inorganic substances
0.705 0.295 0.000
T54 Toxic effect of corrosive substances
0.705 0.295 0.000
T53 Toxic effect of halogen derivatives of aliphatic and aromatic hydrocarbone
0.705 0.295 0.000
T52 Toxic effect of organic solvents
0.705 0.295 0.000
T64 Toxic effect of aflatoxin and other mycotoxin food contaminants
0.705 0.295 0.000
T55 Toxic effect of soaps and detergents
0.705 0.295 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.705 0.295 0.000
I44 Atrioventricular and left bundle-branch block
0.705 0.295 0.000
T86.4 Liver transplant failure and rejection
0.704 0.296 0.000
T84.3 Mechanical complication of other bone devices, implants and grafts
0.704 0.296 0.000
S80 Superficial injury of lower leg
0.704 0.296 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.703 0.297 0.000
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft
0.703 0.297 0.000
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis
0.703 0.297 0.000
I34.1 Mitral (valve) prolapse
0.703 0.297 0.000
T82.0 Mechanical complication of heart valve prosthesis
0.702 0.298 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.701 0.299 0.000
Q35-Q37 Cleft lip and cleft palate
0.701 0.299 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.701 0.299 0.000
W20-W49 Exposure to inanimate mechanical forces
0.701 0.299 0.000
Z91 Personal history of risk-factors, not elsewhere classified
0.701 0.299 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.700 0.300 0.000
Z91.5 Personal history of self-harm
0.700 0.300 0.000
I37 Pulmonary valve disorders
0.699 0.300 0.000
Chapter I Certain infectious and parasitic diseases
0.697 0.303 0.000
I51.6 Cardiovascular disease, unspecified
0.697 0.303 0.000
I51.5 Myocardial degeneration
0.697 0.303 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.697 0.303 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.697 0.303 0.000
T39.4 Antirheumatics, not elsewhere classified
0.696 0.304 0.000
T39.2 Pyrazolone derivatives
0.696 0.304 0.000
I23 Certain current complications following acute myocardial infarction
0.696 0.304 0.000
G47 Sleep disorders
0.696 0.304 0.000
T43.9 Psychotropic drug, unspecified
0.694 0.306 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.694 0.306 0.000
T43.6 Psychostimulants with abuse potential
0.694 0.306 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.694 0.306 0.000
Y48.4 Anaesthetic, unspecified
0.693 0.307 0.000
V29 Motorcycle rider injured in other and unspecified transport accidents
0.692 0.308 0.000
V27 Motorcycle rider injured in collision with fixed or stationary object
0.692 0.308 0.000
V26 Motorcycle rider injured in collision with other nonmotor vehicle
0.692 0.308 0.000
V25 Motorcycle rider injured in collision with railway train or railway vehicle
0.692 0.308 0.000
V24 Motorcycle rider injured in collision with heavy transport vehicle or bus
0.692 0.308 0.000
V22 Motorcycle rider injured in collision with two- or three-wheeled motor vehicle
0.692 0.308 0.000
V21 Motorcycle rider injured in collision with pedal cycle
0.692 0.308 0.000
V20 Motorcycle rider injured in collision with pedestrian or animal
0.692 0.308 0.000
I22.9 Subsequent myocardial infarction of unspecified site
0.692 0.308 0.000
T59 Toxic effect of other gases, fumes and vapours
0.692 0.308 0.000
I45.3 Trifascicular block
0.690 0.310 0.000
Y59 Other and unspecified vaccines and biological substances
0.689 0.311 0.000
Y58 Bacterial vaccines
0.689 0.311 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.689 0.311 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.689 0.311 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.689 0.311 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.689 0.311 0.000
T88.7 Unspecified adverse effect of drug or medicament
0.689 0.311 0.000
I05 Rheumatic mitral valve diseases
0.689 0.311 0.000
H81.0 Meniere's disease
0.688 0.312 0.000
S14 Injury of nerves and spinal cord at neck level
0.688 0.312 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.687 0.313 0.000
D03.5 Melanoma in situ of trunk
0.686 0.314 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.686 0.314 0.000
Chapter XXII Codes for special purposes
0.685 0.315 0.000
H73 Other disorders of tympanic membrane
0.685 0.315 0.000
Q60.0 Renal agenesis, unilateral
0.684 0.316 0.000
T51.8 Other alcohols
0.683 0.317 0.000
T51.3 Fusel oil
0.683 0.317 0.000
T51.2 2-Propanol
0.683 0.317 0.000
T51.1 Methanol
0.683 0.317 0.000
Y49.2 Other and unspecified antidepressants
0.683 0.317 0.000
H81.9 Disorder of vestibular function, unspecified
0.682 0.318 0.000
T86.1 Kidney transplant failure and rejection
0.682 0.318 0.000
X50-X57 Overexertion, travel and privation
0.682 0.318 0.000
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms
0.681 0.319 0.000
I42.8 Other cardiomyopathies
0.680 0.320 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.680 0.320 0.000
Q50-Q56 Congenital malformations of genital organs
0.680 0.320 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.679 0.320 0.000
I34.8 Other nonrheumatic mitral valve disorders
0.679 0.321 0.000
I34.2 Nonrheumatic mitral (valve) stenosis
0.679 0.321 0.000
Y45.8 Other analgesics and antipyretics
0.679 0.321 0.000
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified
0.679 0.321 0.000
C50 Malignant neoplasm of breast
0.679 0.321 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.679 0.321 0.000
H72 Perforation of tympanic membrane
0.678 0.322 0.000
J99 Respiratory disorders in diseases classified elsewhere
0.678 0.322 0.000
Y95 Nosocomial condition
0.677 0.323 0.000
I35 Nonrheumatic aortic valve disorders
0.677 0.323 0.000
Y83.5 Amputation of limb(s)
0.677 0.323 0.000
I09 Other rheumatic heart diseases
0.675 0.325 0.000
I06 Rheumatic aortic valve diseases
0.675 0.325 0.000
F31.9 Bipolar affective disorder, unspecified
0.674 0.325 0.000
I24 Other acute ischaemic heart diseases
0.674 0.326 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.673 0.327 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.671 0.329 0.000
Z82 Family history of certain disabilities and chronic diseases leading to disablement
0.671 0.329 0.000
I42.0 Dilated cardiomyopathy
0.670 0.330 0.000
J60-J70 Lung diseases due to external agents
0.669 0.331 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.668 0.332 0.000
I70.1 Atherosclerosis of renal artery
0.667 0.333 0.000
V23.9 Unspecified motorcycle rider injured in traffic accident
0.667 0.333 0.000
V23.5 Passenger injured in traffic accident
0.667 0.333 0.000
V23.3 Person injured while boarding or alighting
0.667 0.333 0.000
V23.2 Unspecified motorcycle rider injured in nontraffic accident
0.667 0.333 0.000
V23.1 Passenger injured in nontraffic accident
0.667 0.333 0.000
V23.0 Driver injured in nontraffic accident
0.667 0.333 0.000
F31.8 Other bipolar affective disorders
0.666 0.333 0.000
F31.7 Bipolar affective disorder, currently in remission
0.666 0.333 0.000
F31.5 Bipolar affective disorder, current episode severe depression with psychotic symptoms
0.666 0.333 0.000
F31.4 Bipolar affective disorder, current episode severe depression without psychotic symptoms
0.666 0.333 0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft
0.666 0.334 0.000
V18 Pedal cyclist injured in noncollision transport accident
0.666 0.334 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.665 0.335 0.000
F17 Mental and behavioural disorders due to use of tobacco
0.664 0.336 0.000
X78 Intentional self-harm by sharp object
0.663 0.337 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.663 0.337 0.000
Z95.8 Presence of other cardiac and vascular implants and grafts
0.663 0.337 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.662 0.338 0.000
C64-C68 Malignant neoplasms of urinary tract
0.660 0.340 0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified
0.659 0.341 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.659 0.341 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.659 0.341 0.000
Y48.3 Local anaesthetics
0.658 0.342 0.000
T63.4 Venom of other arthropods
0.657 0.343 0.000
S12.2 Fracture of other specified cervical vertebra
0.657 0.343 0.000
Q65 Congenital deformities of hip
0.655 0.345 0.000
I42.6 Alcoholic cardiomyopathy
0.655 0.345 0.000
S89.9 Unspecified injury of lower leg
0.654 0.346 0.000
G45.8 Other transient cerebral ischaemic attacks and related syndromes
0.654 0.346 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.653 0.347 0.000
D05.7 Other carcinoma in situ of breast
0.652 0.348 0.000
H74 Other disorders of middle ear and mastoid
0.651 0.349 0.000
I33 Acute and subacute endocarditis
0.651 0.349 0.000
Y52 Agents primarily affecting the cardiovascular system
0.650 0.349 0.000
C50.8 Overlapping lesion of breast
0.649 0.351 0.000
X62 Intentional self-poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified
0.648 0.352 0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.648 0.352 0.000
I08.8 Other multiple valve diseases
0.648 0.352 0.000
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified
0.648 0.352 0.000
Y45.5 4-Aminophenol derivatives
0.648 0.352 0.000
Y45.4 Antirheumatics
0.648 0.352 0.000
Q61.0 Congenital single renal cyst
0.647 0.353 0.000
Q64 Other congenital malformations of urinary system
0.647 0.353 0.000
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter
0.647 0.353 0.000
S90 Superficial injury of ankle and foot
0.646 0.354 0.000
I51.4 Myocarditis, unspecified
0.646 0.354 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.646 0.354 0.000
Y45.2 Propionic acid derivatives
0.645 0.355 0.000
T82.1 Mechanical complication of cardiac electronic device
0.645 0.355 0.000
Y57 Other and unspecified drugs and medicaments
0.645 0.355 0.000
S50 Superficial injury of forearm
0.645 0.355 0.000
J43.2 Centrilobular emphysema
0.644 0.356 0.000
F32.1 Moderate depressive episode
0.644 0.356 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.644 0.356 0.000
F32.9 Depressive episode, unspecified
0.643 0.357 0.000
I45.5 Other specified heart block
0.643 0.357 0.000
F45 Somatoform disorders
0.643 0.357 0.000
F33.1 Recurrent depressive disorder, current episode moderate
0.642 0.358 0.000
Z95.2 Presence of prosthetic heart valve
0.642 0.358 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.641 0.359 0.000
T92 Sequelae of injuries of upper limb
0.640 0.360 0.000
F33.3 Recurrent depressive disorder, current episode severe with psychotic symptoms
0.640 0.360 0.000
T93 Sequelae of injuries of lower limb
0.640 0.360 0.000
B35-B49 Mycoses
0.639 0.361 0.000
V28.9 Unspecified motorcycle rider injured in traffic accident
0.639 0.361 0.000
G40.6 Grand mal seizures, unspecified (with or without petit mal)
0.639 0.361 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.638 0.361 0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.638 0.362 0.000
T42.5 Mixed antiepileptics, not elsewhere classified
0.638 0.362 0.000
T42.3 Barbiturates
0.638 0.362 0.000
T42.2 Succinimides and oxazolidinediones
0.638 0.362 0.000
T42.1 Iminostilbenes
0.638 0.362 0.000
T42.0 Hydantoin derivatives
0.638 0.362 0.000
I42.1 Obstructive hypertrophic cardiomyopathy
0.637 0.363 0.000
F84 Pervasive developmental disorders
0.636 0.364 0.000
F33.0 Recurrent depressive disorder, current episode mild
0.636 0.364 0.000
I30.9 Acute pericarditis, unspecified
0.635 0.365 0.000
S10 Superficial injury of neck
0.634 0.366 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.633 0.367 0.000
F25 Schizoaffective disorders
0.633 0.367 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.631 0.369 0.000
Q27 Other congenital malformations of peripheral vascular system
0.631 0.369 0.000
Q23 Congenital malformations of aortic and mitral valves
0.630 0.370 0.000
F11.2 Dependence syndrome
0.629 0.370 0.000
Z89 Acquired absence of limb
0.629 0.371 0.000
Q24 Other congenital malformations of heart
0.629 0.371 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.628 0.372 0.000
Q76 Congenital malformations of spine and bony thorax
0.628 0.372 0.000
D03.6 Melanoma in situ of upper limb, including shoulder
0.627 0.373 0.000
X29 Contact with unspecified venomous animal or plant
0.626 0.373 0.000
X28 Contact with other specified venomous plants
0.626 0.373 0.000
X27 Contact with other specified venomous animals
0.626 0.373 0.000
X26 Contact with venomous marine animals and plants
0.626 0.373 0.000
X25 Contact with other specified venomous arthropods
0.626 0.373 0.000
X24 Contact with centipedes and venomous millipedes (tropical)
0.626 0.373 0.000
X22 Contact with scorpions
0.626 0.373 0.000
X21 Contact with venomous spiders
0.626 0.373 0.000
X20 Contact with venomous snakes and lizards
0.626 0.373 0.000
Z90 Acquired absence of organs, not elsewhere classified
0.625 0.375 0.000
F99-F99 Unspecified mental disorder
0.625 0.375 0.000
I42.2 Other hypertrophic cardiomyopathy
0.625 0.375 0.000
G70-G73 Diseases of myoneural junction and muscle
0.625 0.375 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.624 0.376 0.000
S17 Crushing injury of neck
0.623 0.377 0.000
S15 Injury of blood vessels at neck level
0.623 0.377 0.000
S13 Dislocation, sprain and strain of joints and ligaments at neck level
0.623 0.377 0.000
S11 Open wound of neck
0.623 0.377 0.000
S18 Traumatic amputation at neck level
0.623 0.377 0.000
S16 Injury of muscle and tendon at neck level
0.623 0.377 0.000
F81 Specific developmental disorders of scholastic skills
0.622 0.378 0.000
S86 Injury of muscle and tendon at lower leg level
0.622 0.378 0.000
G43 Migraine
0.621 0.378 0.000
S99 Other and unspecified injuries of ankle and foot
0.620 0.379 0.000
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.620 0.379 0.000
H69 Other disorders of Eustachian tube
0.620 0.380 0.000
T80.2 Infections following infusion, transfusion and therapeutic injection
0.619 0.381 0.000
I73.0 Raynaud's syndrome
0.619 0.381 0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level
0.618 0.382 0.000
I50.0 Congestive heart failure
0.618 0.382 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.618 0.382 0.000
F33.8 Other recurrent depressive disorders
0.618 0.382 0.000
F33.4 Recurrent depressive disorder, currently in remission
0.618 0.382 0.000
Y53.4 Other laxatives
0.618 0.382 0.000
Z82.4 Family history of ischaemic heart disease and other diseases of the circulatory system
0.617 0.383 0.000
X63 Intentional self-poisoning by and exposure to other drugs acting on the autonomic nervous system
0.616 0.384 0.000
I42.7 Cardiomyopathy due to drugs and other external agents
0.615 0.384 0.000
I42.5 Other restrictive cardiomyopathy
0.615 0.384 0.000
I42.4 Endocardial fibroelastosis
0.615 0.384 0.000
I42.3 Endomyocardial (eosinophilic) disease
0.615 0.384 0.000
I42.9 Cardiomyopathy, unspecified
0.615 0.385 0.000
F40 Phobic anxiety disorders
0.615 0.385 0.000
I70.2 Atherosclerosis of arteries of the extremities
0.615 0.385 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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