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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs6457374
log Bayes Factor = 249.684
Chromosome 6   position 31,272,261  (GRCh37) Explore rs6457374 on Ensembl!
Variant rs6457374 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
D69.6 Thrombocytopenia, unspecified
1.000 0.000 0.000
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
E05.0 Thyrotoxicosis with diffuse goitre
1.000 0.000 0.000
K90.0 Coeliac disease
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
M35.0 Sicca syndrome [Sjogren]
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
G35 Multiple sclerosis
1.000 0.000 0.000
R31 Unspecified haematuria
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
E10.9 Without complications
1.000 0.000 0.000
D69 Purpura and other haemorrhagic conditions
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
E03 Other hypothyroidism
1.000 0.000 0.000
D80-D89 Certain disorders involving the immune mechanism
1.000 0.000 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
1.000 0.000 0.000
E27.1 Primary adrenocortical insufficiency
1.000 0.000 0.000
M35 Other systemic involvement of connective tissue
1.000 0.000 0.000
G35-G37 Demyelinating diseases of the central nervous system
1.000 0.000 0.000
Chapter VI Diseases of the nervous system
0.999 0.001 0.000
E10.3 With ophthalmic complications
0.999 0.001 0.000
M20-M25 Other joint disorders
0.999 0.001 0.000
Chapter I Certain infectious and parasitic diseases
0.999 0.001 0.000
L40 Psoriasis
0.000 0.001 0.999
D50-D53 Nutritional anaemias
0.999 0.001 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.998 0.002 0.000
E27 Other disorders of adrenal gland
0.997 0.003 0.000
E20-E35 Disorders of other endocrine glands
0.997 0.003 0.000
H36.0 Diabetic retinopathy
0.997 0.003 0.000
D86 Sarcoidosis
0.996 0.004 0.000
E50-E64 Other nutritional deficiencies
0.996 0.004 0.000
H36 Retinal disorders in diseases classified elsewhere
0.996 0.004 0.000
Chapter VII Diseases of the eye and adnexa
0.996 0.004 0.000
H30-H36 Disorders of choroid and retina
0.995 0.005 0.000
L40.5 Arthropathic psoriasis
0.000 0.006 0.994
D86.9 Sarcoidosis, unspecified
0.994 0.006 0.000
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.006 0.994
E53 Deficiency of other B group vitamins
0.992 0.008 0.000
K90 Intestinal malabsorption
0.990 0.010 0.000
E53.8 Deficiency of other specified B group vitamins
0.987 0.013 0.000
M60-M63 Disorders of muscles
0.986 0.014 0.000
E10.1 With ketoacidosis
0.984 0.016 0.000
D51 Vitamin B12 deficiency anaemia
0.984 0.016 0.000
E14 Unspecified diabetes mellitus
0.980 0.020 0.000
E10.2 With renal complications
0.978 0.022 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.976 0.024 0.000
E14.3 With ophthalmic complications
0.975 0.025 0.000
D50 Iron deficiency anaemia
0.973 0.027 0.000
K90-K93 Other diseases of the digestive system
0.973 0.027 0.000
Chapter XI Diseases of the digestive system
0.973 0.027 0.000
K70-K77 Diseases of liver
0.971 0.029 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.969 0.031 0.000
K75 Other inflammatory liver diseases
0.968 0.032 0.000
B35-B49 Mycoses
0.967 0.033 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.966 0.034 0.000
E89.0 Postprocedural hypothyroidism
0.965 0.035 0.000
K75.4 Autoimmune hepatitis
0.964 0.036 0.000
M62 Other disorders of muscle
0.961 0.039 0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.960 0.040 0.000
E70-E90 Metabolic disorders
0.958 0.042 0.000
B37 Candidiasis
0.957 0.043 0.000
B25-B34 Other viral diseases
0.956 0.044 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.956 0.044 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.946 0.054 0.000
I25 Chronic ischaemic heart disease
0.000 0.054 0.946
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.945 0.055 0.000
B37.8 Candidiasis of other sites
0.945 0.055 0.000
E06 Thyroiditis
0.944 0.056 0.000
D50.9 Iron deficiency anaemia, unspecified
0.942 0.058 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.940 0.060 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.940 0.060 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.938 0.062 0.000
B07 Viral warts
0.938 0.062 0.000
I20-I25 Ischaemic heart diseases
0.000 0.065 0.935
M34 Systemic sclerosis
0.933 0.067 0.000
B25 Cytomegaloviral disease
0.932 0.068 0.000
I25.1 Atherosclerotic heart disease
0.000 0.069 0.931
M45 Ankylosing spondylitis
0.002 0.069 0.929
H34 Retinal vascular occlusions
0.930 0.070 0.000
I20 Angina pectoris
0.000 0.070 0.930
A30-A49 Other bacterial diseases
0.929 0.071 0.000
B37.9 Candidiasis, unspecified
0.928 0.072 0.000
R30-R39 Symptoms and signs involving the urinary system
0.000 0.074 0.926
G00 Bacterial meningitis, not elsewhere classified
0.925 0.075 0.000
M62.8 Other specified disorders of muscle
0.924 0.076 0.000
I20.0 Unstable angina
0.000 0.078 0.922
R30.0 Dysuria
0.000 0.078 0.922
R30 Pain associated with micturition
0.000 0.078 0.922
K73 Chronic hepatitis, not elsewhere classified
0.917 0.083 0.000
M21 Other acquired deformities of limbs
0.909 0.091 0.000
M40-M43 Deforming dorsopathies
0.909 0.091 0.000
B25.9 Cytomegaloviral disease, unspecified
0.908 0.092 0.000
K70 Alcoholic liver disease
0.906 0.094 0.000
M32 Systemic lupus erythematosus
0.903 0.097 0.000
D80 Immunodeficiency with predominantly antibody defects
0.903 0.097 0.000
A63 Other predominantly sexually transmitted diseases, not elsewhere classified
0.902 0.098 0.000
L40.8 Other psoriasis
0.000 0.098 0.902
M35.3 Polymyalgia rheumatica
0.898 0.102 0.000
G30-G32 Other degenerative diseases of the nervous system
0.898 0.102 0.000
D55-D59 Haemolytic anaemias
0.898 0.102 0.000
E16 Other disorders of pancreatic internal secretion
0.897 0.103 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.897 0.103 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.109 0.891
M60 Myositis
0.890 0.110 0.000
E06.3 Autoimmune thyroiditis
0.890 0.110 0.000
I25.2 Old myocardial infarction
0.000 0.115 0.885
D89.2 Hypergammaglobulinaemia, unspecified
0.885 0.115 0.000
M35.7 Hypermobility syndrome
0.884 0.116 0.000
K75.8 Other specified inflammatory liver diseases
0.880 0.120 0.000
A41 Other septicaemia
0.879 0.121 0.000
H05 Disorders of orbit
0.876 0.124 0.000
D60-D64 Aplastic and other anaemias
0.875 0.125 0.000
A63.0 Anogenital (venereal) warts
0.875 0.125 0.000
G09 Sequelae of inflammatory diseases of central nervous system
0.874 0.126 0.000
K70.9 Alcoholic liver disease, unspecified
0.873 0.127 0.000
I25.5 Ischaemic cardiomyopathy
0.000 0.128 0.872
B20-B24 Human immunodeficiency virus [HIV] disease
0.872 0.128 0.000
E55 Vitamin D deficiency
0.871 0.128 0.000
L40.0 Psoriasis vulgaris
0.000 0.130 0.870
M21.0 Valgus deformity, not elsewhere classified
0.870 0.130 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.869 0.131 0.000
E16.2 Hypoglycaemia, unspecified
0.869 0.131 0.000
D69.4 Other primary thrombocytopenia
0.865 0.134 0.000
E73 Lactose intolerance
0.864 0.136 0.000
D69.2 Other nonthrombocytopenic purpura
0.863 0.137 0.000
H06.2 Dysthyroid exophthalmos
0.862 0.138 0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.001 0.141 0.859
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.859 0.141 0.000
H10-H13 Disorders of conjunctiva
0.859 0.141 0.000
D72 Other disorders of white blood cells
0.858 0.142 0.000
K73.2 Chronic active hepatitis, not elsewhere classified
0.858 0.142 0.000
D59 Acquired haemolytic anaemia
0.855 0.145 0.000
H30 Chorioretinal inflammation
0.854 0.146 0.000
M86-M90 Other osteopathies
0.851 0.149 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.851 0.149 0.000
E53.9 Vitamin B deficiency, unspecified
0.850 0.150 0.000
M21.06 Valgus deformity, not elsewhere classified (Lower leg)
0.849 0.151 0.000
B01 Varicella [chickenpox]
0.845 0.155 0.000
E20 Hypoparathyroidism
0.844 0.156 0.000
G08 Intracranial and intraspinal phlebitis and thrombophlebitis
0.844 0.156 0.000
M43 Other deforming dorsopathies
0.843 0.157 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.843 0.157 0.000
I20.9 Angina pectoris, unspecified
0.000 0.157 0.843
L10-L14 Bullous disorders
0.843 0.157 0.000
H16 Keratitis
0.842 0.158 0.000
M62.85 Other specified disorders of muscle (Pelvic region and thigh)
0.840 0.160 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.840 0.160 0.000
D70 Agranulocytosis
0.839 0.161 0.000
M34.8 Other forms of systemic sclerosis
0.839 0.161 0.000
M21.8 Other specified acquired deformities of limbs
0.838 0.162 0.000
M32.1 Systemic lupus erythematosus with organ or system involvement
0.837 0.163 0.000
I22 Subsequent myocardial infarction
0.000 0.165 0.835
D61 Other aplastic anaemias
0.835 0.165 0.000
R39 Other symptoms and signs involving the urinary system
0.000 0.167 0.833
E27.2 Addisonian crisis
0.831 0.169 0.000
D69.5 Secondary thrombocytopenia
0.831 0.169 0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.831 0.169 0.000
A41.5 Septicaemia due to other Gram-negative organisms
0.827 0.173 0.000
E31 Polyglandular dysfunction
0.824 0.176 0.000
A41.9 Septicaemia, unspecified
0.822 0.178 0.000
B44 Aspergillosis
0.822 0.178 0.000
D50.1 Sideropenic dysphagia
0.822 0.178 0.000
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.179 0.821
D89.9 Disorder involving the immune mechanism, unspecified
0.820 0.180 0.000
D86.3 Sarcoidosis of skin
0.819 0.181 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.818 0.182 0.000
H34.8 Other retinal vascular occlusions
0.817 0.183 0.000
G00.9 Bacterial meningitis, unspecified
0.816 0.184 0.000
R39.8 Other and unspecified symptoms and signs involving the urinary system
0.000 0.185 0.815
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.814 0.186 0.000
G06 Intracranial and intraspinal abscess and granuloma
0.812 0.188 0.000
M62.80 Other specified disorders of muscle (Multiple sites)
0.811 0.189 0.000
B27 Infectious mononucleosis
0.810 0.190 0.000
D61.9 Aplastic anaemia, unspecified
0.810 0.190 0.000
H16.0 Corneal ulcer
0.806 0.194 0.000
E03.8 Other specified hypothyroidism
0.805 0.195 0.000
H05.2 Exophthalmic conditions
0.804 0.196 0.000
E83 Disorders of mineral metabolism
0.803 0.197 0.000
G31.9 Degenerative disease of nervous system, unspecified
0.802 0.198 0.000
H34.2 Other retinal artery occlusions
0.802 0.198 0.000
E10.4 With neurological complications
0.801 0.199 0.000
M62.5 Muscle wasting and atrophy, not elsewhere classified
0.801 0.199 0.000
D80.1 Nonfamilial hypogammaglobulinaemia
0.798 0.202 0.000
D83 Common variable immunodeficiency
0.798 0.202 0.000
D69.8 Other specified haemorrhagic conditions
0.797 0.203 0.000
E73.9 Lactose intolerance, unspecified
0.796 0.204 0.000
M86 Osteomyelitis
0.793 0.207 0.000
H31 Other disorders of choroid
0.793 0.207 0.000
L50-L54 Urticaria and erythema
0.793 0.207 0.000
L13 Other bullous disorders
0.793 0.207 0.000
G37 Other demyelinating diseases of central nervous system
0.791 0.209 0.000
M60.9 Myositis, unspecified
0.790 0.210 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.789 0.211 0.000
K90.9 Intestinal malabsorption, unspecified
0.787 0.213 0.000
M45.X2 Ankylosing spondylitis (Cervical region)
0.001 0.214 0.785
G00.1 Pneumococcal meningitis
0.784 0.216 0.000
E55.9 Vitamin D deficiency, unspecified
0.782 0.218 0.000
M34.0 Progressive systemic sclerosis
0.782 0.218 0.000
D86.1 Sarcoidosis of lymph nodes
0.780 0.220 0.000
E10.7 With multiple complications
0.780 0.220 0.000
M62.83 Other specified disorders of muscle (Forearm)
0.777 0.223 0.000
L20-L30 Dermatitis and eczema
0.774 0.226 0.000
I25.3 Aneurysm of heart
0.000 0.229 0.771
E83.1 Disorders of iron metabolism
0.770 0.230 0.000
M43.0 Spondylolysis
0.769 0.231 0.000
L40.1 Generalised pustular psoriasis
0.000 0.232 0.768
D59.9 Acquired haemolytic anaemia, unspecified
0.768 0.232 0.000
D72.8 Other specified disorders of white blood cells
0.768 0.232 0.000
D64 Other anaemias
0.766 0.234 0.000
D84 Other immunodeficiencies
0.765 0.235 0.000
B24 Unspecified human immunodeficiency virus [HIV] disease
0.762 0.237 0.000
D89.0 Polyclonal hypergammaglobulinaemia
0.762 0.238 0.000
G00.2 Streptococcal meningitis
0.762 0.238 0.000
K73.9 Chronic hepatitis, unspecified
0.762 0.238 0.000
M62.2 Ischaemic infarction of muscle
0.762 0.238 0.000
H11 Other disorders of conjunctiva
0.761 0.239 0.000
D53 Other nutritional anaemias
0.761 0.239 0.000
M31 Other necrotising vasculopathies
0.760 0.240 0.000
E14.2 Withrenal complications
0.758 0.242 0.000
M34.9 Systemic sclerosis, unspecified
0.757 0.243 0.000
L13.0 Dermatitis herpetiformis
0.757 0.243 0.000
H46 Optic neuritis
0.757 0.243 0.000
B25.0 Cytomegaloviral pneumonitis
0.757 0.243 0.000
B37.2 Candidiasis of skin and nail
0.757 0.243 0.000
A48 Other bacterial diseases, not elsewhere classified
0.756 0.244 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.756 0.244 0.000
E10.8 With unspecified complications
0.754 0.246 0.000
M62.81 Other specified disorders of muscle (Shoulder region)
0.754 0.246 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.754 0.246 0.000
M21.86 Other specified acquired deformities of limbs (Lower leg)
0.753 0.247 0.000
D51.8 Other vitamin B12 deficiency anaemias
0.752 0.248 0.000
K70.2 Alcoholic fibrosis and sclerosis of liver
0.751 0.249 0.000
H18 Other disorders of cornea
0.750 0.250 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.749 0.251 0.000
E10.6 With other specified complications
0.749 0.251 0.000
I23 Certain current complications following acute myocardial infarction
0.000 0.253 0.747
D66 Hereditary factor VIII deficiency
0.746 0.254 0.000
E51 Thiamine deficiency
0.746 0.254 0.000
D59.1 Other autoimmune haemolytic anaemias
0.745 0.255 0.000
E06.9 Thyroiditis, unspecified
0.744 0.256 0.000
M40 Kyphosis and lordosis
0.742 0.258 0.000
E14.6 With other specified complications
0.741 0.259 0.000
R34 Anuria and oliguria
0.000 0.259 0.741
B00 Herpesviral [herpes simplex] infections
0.741 0.259 0.000
D52 Folate deficiency anaemia
0.740 0.259 0.000
G70-G73 Diseases of myoneural junction and muscle
0.740 0.260 0.000
H02 Other disorders of eyelid
0.739 0.261 0.000
M62.86 Other specified disorders of muscle (Lower leg)
0.738 0.262 0.000
B08 Other viral infections characterised by skin and mucous membrane lesions, not elsewhere classified
0.737 0.262 0.000
D75 Other diseases of blood and blood-forming organs
0.737 0.263 0.000
E20.9 Hypoparathyroidism, unspecified
0.735 0.265 0.000
B01.9 Varicella without complications
0.733 0.267 0.000
E05.8 Other thyrotoxicosis
0.732 0.268 0.000
K44.9 Diaphragmatic hernia without obstruction or gangrene
0.000 0.270 0.730
H11.0 Pterygium
0.729 0.271 0.000
H30.9 Chorioretinal inflammation, unspecified
0.728 0.271 0.000
E10.5 With peripheral circulatory complications
0.728 0.272 0.000
A46 Erysipelas
0.728 0.272 0.000
D89.1 Cryoglobulinaemia
0.728 0.272 0.000
M00-M03 Infectious arthropathies
0.728 0.272 0.000
A40 Streptococcal septicaemia
0.727 0.273 0.000
R35 Polyuria
0.000 0.274 0.726
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.726 0.274 0.000
H16.9 Keratitis, unspecified
0.725 0.275 0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.723 0.277 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.277 0.723
E07 Other disorders of thyroid
0.721 0.279 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.721 0.279 0.000
H02.5 Other disorders affecting eyelid function
0.720 0.280 0.000
A41.2 Septicaemia due to unspecified staphylococcus
0.720 0.280 0.000
M43.02 Spondylolysis (Cervical region)
0.719 0.281 0.000
H34.9 Retinal vascular occlusion, unspecified
0.719 0.281 0.000
D69.1 Qualitative platelet defects
0.717 0.283 0.000
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
E03.5 Myxoedema coma
0.717 0.283 0.000
E03.4 Atrophy of thyroid (acquired)
0.717 0.283 0.000
E03.3 Postinfectious hypothyroidism
0.717 0.283 0.000
E03.1 Congenital hypothyroidism without goitre
0.717 0.283 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.717 0.283 0.000
D67 Hereditary factor IX deficiency
0.717 0.283 0.000
D82 Immunodeficiency associated with other major defects
0.717 0.283 0.000
D81 Combined immunodeficiencies
0.717 0.283 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.717 0.283 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.717 0.283 0.000
M35.5 Multifocal fibrosclerosis
0.717 0.283 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.717 0.283 0.000
L52 Erythema nodosum
0.716 0.283 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.716 0.284 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.716 0.284 0.000
A75-A79 Rickettsioses
0.716 0.284 0.000
A70-A74 Other diseases caused by chlamydiae
0.716 0.284 0.000
A20-A28 Certain zoonotic bacterial diseases
0.716 0.284 0.000
L40.4 Guttate psoriasis
0.000 0.284 0.716
L40.2 Acrodermatitis continua
0.000 0.284 0.716
E14.5 With peripheral circulatory complications
0.715 0.285 0.000
E27.5 Adrenomedullary hyperfunction
0.715 0.285 0.000
E27.0 Other adrenocortical overactivity
0.715 0.285 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.715 0.285 0.000
E32 Diseases of thymus
0.715 0.285 0.000
E30 Disorders of puberty, not elsewhere classified
0.715 0.285 0.000
E25 Adrenogenital disorders
0.715 0.285 0.000
E14.8 With unspecified complications
0.715 0.285 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.714 0.286 0.000
E63 Other nutritional deficiencies
0.714 0.286 0.000
E56 Other vitamin deficiencies
0.714 0.286 0.000
E50 Vitamin A deficiency
0.714 0.286 0.000
E60 Dietary zinc deficiency
0.714 0.286 0.000
E59 Dietary selenium deficiency
0.714 0.286 0.000
E54 Ascorbic acid deficiency
0.714 0.286 0.000
E52 Niacin deficiency [pellagra]
0.714 0.286 0.000
H36.8 Other retinal disorders in diseases classified elsewhere
0.714 0.286 0.000
K75.3 Granulomatous hepatitis, not elsewhere classified
0.714 0.286 0.000
G31.2 Degeneration of nervous system due to alcohol
0.714 0.286 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.714 0.286 0.000
M60.99 Myositis, unspecified (Site unspecified)
0.713 0.287 0.000
M24 Other specific joint derangements
0.713 0.287 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.713 0.287 0.000
H05.0 Acute inflammation of orbit
0.712 0.288 0.000
E53.1 Pyridoxine deficiency
0.711 0.289 0.000
E53.0 Riboflavin deficiency
0.711 0.289 0.000
K90.3 Pancreatic steatorrhoea
0.710 0.290 0.000
K90.2 Blind loop syndrome, not elsewhere classified
0.710 0.290 0.000
K90.1 Tropical sprue
0.710 0.290 0.000
M63 Disorders of muscle in diseases classified elsewhere
0.707 0.293 0.000
M61 Calcification and ossification of muscle
0.707 0.293 0.000
D51.3 Other dietary vitamin B12 deficiency anaemia
0.705 0.294 0.000
D51.2 Transcobalamin II deficiency
0.705 0.294 0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.705 0.294 0.000
M62.6 Muscle strain
0.704 0.296 0.000
L11 Other acantholytic disorders
0.703 0.296 0.000
E14.7 With multiple complications
0.703 0.297 0.000
E14.0 With coma
0.703 0.297 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.703 0.297 0.000
L21 Seborrhoeic dermatitis
0.702 0.298 0.000
M23 Internal derangement of knee
0.701 0.299 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.700 0.299 0.000
M30 Polyarteritis nodosa and related conditions
0.700 0.300 0.000
E31.0 Autoimmune polyglandular failure
0.700 0.300 0.000
G07 Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere
0.700 0.300 0.000
B27.9 Infectious mononucleosis, unspecified
0.699 0.301 0.000
B33 Other viral diseases, not elsewhere classified
0.699 0.301 0.000
E14.1 With ketoacidosis
0.698 0.302 0.000
E34 Other endocrine disorders
0.698 0.302 0.000
G36 Other acute disseminated demyelination
0.698 0.302 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.698 0.302 0.000
K77 Liver disorders in diseases classified elsewhere
0.696 0.304 0.000
K71 Toxic liver disease
0.696 0.304 0.000
A31 Infection due to other mycobacteria
0.696 0.304 0.000
G06.0 Intracranial abscess and granuloma
0.695 0.305 0.000
B06 Rubella [German measles]
0.695 0.305 0.000
B05 Measles
0.695 0.305 0.000
B09 Unspecified viral infection characterised by skin and mucous membrane lesions
0.695 0.305 0.000
B04 Monkeypox
0.695 0.305 0.000
B03 Smallpox
0.695 0.305 0.000
K90.8 Other intestinal malabsorption
0.694 0.306 0.000
B44.9 Aspergillosis, unspecified
0.694 0.306 0.000
K75.2 Nonspecific reactive hepatitis
0.694 0.306 0.000
K75.1 Phlebitis of portal vein
0.694 0.306 0.000
M90 Osteopathies in diseases classified elsewhere
0.694 0.306 0.000
B48 Other mycoses, not elsewhere classified
0.693 0.306 0.000
B47 Mycetoma
0.693 0.306 0.000
B46 Zygomycosis
0.693 0.306 0.000
B45 Cryptococcosis
0.693 0.306 0.000
B43 Chromomycosis and phaeomycotic abscess
0.693 0.306 0.000
B42 Sporotrichosis
0.693 0.306 0.000
B41 Paracoccidioidomycosis
0.693 0.306 0.000
B40 Blastomycosis
0.693 0.306 0.000
B39 Histoplasmosis
0.693 0.306 0.000
B38 Coccidioidomycosis
0.693 0.306 0.000
D89.3 Immune reconstitution syndrome
0.692 0.308 0.000
M35.8 Other specified systemic involvement of connective tissue
0.691 0.309 0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.691 0.309 0.000
B37.4 Candidiasis of other urogenital sites
0.690 0.310 0.000
L40-L45 Papulosquamous disorders
0.237 0.310 0.453
M62.4 Contracture of muscle
0.689 0.311 0.000
M62.3 Immobility syndrome (paraplegic)
0.689 0.311 0.000
D72.1 Eosinophilia
0.689 0.311 0.000
B37.7 Candidal septicaemia
0.688 0.312 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.688 0.312 0.000
B36 Other superficial mycoses
0.688 0.312 0.000
D69.9 Haemorrhagic condition, unspecified
0.687 0.312 0.000
E77 Disorders of glycoprotein metabolism
0.687 0.313 0.000
E76 Disorders of glycosaminoglycan metabolism
0.687 0.313 0.000
E72 Other disorders of amino-acid metabolism
0.687 0.313 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.687 0.313 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.687 0.313 0.000
B37.6 Candidal endocarditis
0.686 0.314 0.000
B37.5 Candidal meningitis
0.686 0.314 0.000
B30 Viral conjunctivitis
0.686 0.314 0.000
B26 Mumps
0.686 0.314 0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.685 0.314 0.000
E89.8 Other postprocedural endocrine and metabolic disorders
0.685 0.314 0.000
E89.5 Postprocedural testicular hypofunction
0.685 0.314 0.000
E89.1 Postprocedural hypoinsulinaemia
0.685 0.314 0.000
M22 Disorders of patella
0.686 0.314 0.000
H18.6 Keratoconus
0.685 0.315 0.000
E10.0 With coma
0.684 0.316 0.000
M62.82 Other specified disorders of muscle (Upper arm)
0.683 0.317 0.000
M23.4 Loose body in knee
0.683 0.317 0.000
E24 Cushing's syndrome
0.681 0.319 0.000
H02.0 Entropion and trichiasis of eyelid
0.680 0.320 0.000
E70 Disorders of aromatic amino-acid metabolism
0.679 0.320 0.000
D74 Methaemoglobinaemia
0.679 0.321 0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.679 0.321 0.000
D71 Functional disorders of polymorphonuclear neutrophils
0.679 0.321 0.000
M86.9 Osteomyelitis, unspecified
0.679 0.321 0.000
A15-A19 Tuberculosis
0.678 0.322 0.000
A39 Meningococcal infection
0.678 0.322 0.000
E84 Cystic fibrosis
0.677 0.323 0.000
H18.1 Bullous keratopathy
0.677 0.323 0.000
E06.5 Other chronic thyroiditis
0.677 0.323 0.000
E06.4 Drug-induced thyroiditis
0.677 0.323 0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.677 0.323 0.000
E06.1 Subacute thyroiditis
0.677 0.323 0.000
E06.0 Acute thyroiditis
0.677 0.323 0.000
M62.0 Diastasis of muscle
0.676 0.324 0.000
M62.9 Disorder of muscle, unspecified
0.676 0.324 0.000
M23.49 Loose body in knee-Unspec lig/men
0.675 0.325 0.000
M21.6 Other acquired deformities of ankle and foot
0.675 0.325 0.000
M60.0 Infective myositis
0.675 0.325 0.000
M21.85 Other specified acquired deformities of limbs (Pelvic region and thigh)
0.674 0.325 0.000
E15 Nondiabetic hypoglycaemic coma
0.674 0.326 0.000
A65-A69 Other spirochaetal diseases
0.674 0.326 0.000
A59 Trichomoniasis
0.674 0.326 0.000
A56 Other sexually transmitted chlamydial diseases
0.674 0.326 0.000
A54 Gonococcal infection
0.674 0.326 0.000
A53 Other and unspecified syphilis
0.674 0.326 0.000
A52 Late syphilis
0.674 0.326 0.000
A51 Early syphilis
0.674 0.326 0.000
A50 Congenital syphilis
0.674 0.326 0.000
A64 Unspecified sexually transmitted disease
0.674 0.326 0.000
A58 Granuloma inguinale
0.674 0.326 0.000
A57 Chancroid
0.674 0.326 0.000
A55 Chlamydial lymphogranuloma (venereum)
0.674 0.326 0.000
M62.1 Other rupture of muscle (nontraumatic)
0.673 0.326 0.000
M60.2 Foreign body granuloma of soft tissue, not elsewhere classified
0.672 0.328 0.000
H05.8 Other disorders of orbit
0.671 0.329 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.670 0.330 0.000
M33 Dermatopolymyositis
0.669 0.331 0.000
M34.2 Systemic sclerosis induced by drugs and chemicals
0.669 0.331 0.000
L12 Pemphigoid
0.669 0.331 0.000
H16.8 Other keratitis
0.669 0.331 0.000
M45.X6 Ankylosing spondylitis (Lumbar region)
0.001 0.332 0.667
B25.2 Cytomegaloviral pancreatitis
0.668 0.332 0.000
B25.1 Cytomegaloviral hepatitis
0.668 0.332 0.000
G37.8 Other specified demyelinating diseases of central nervous system
0.668 0.332 0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.002 0.333 0.666
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.002 0.333 0.666
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.002 0.333 0.666
M45.X4 Ankylosing spondylitis (Thoracic region)
0.002 0.333 0.666
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.002 0.333 0.666
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.002 0.333 0.666
H34.0 Transient retinal artery occlusion
0.667 0.333 0.000
H05.4 Enophthalmos
0.666 0.334 0.000
B23 Human immunodeficiency virus [HIV] disease resulting in other conditions
0.666 0.334 0.000
A44 Bartonellosis
0.666 0.334 0.000
A43 Nocardiosis
0.666 0.334 0.000
A42 Actinomycosis
0.666 0.334 0.000
A37 Whooping cough
0.666 0.334 0.000
A36 Diphtheria
0.666 0.334 0.000
A32 Listeriosis
0.666 0.334 0.000
A30 Leprosy [Hansen's disease]
0.666 0.334 0.000
A38 Scarlet fever
0.666 0.334 0.000
A35 Other tetanus
0.666 0.334 0.000
A34 Obstetrical tetanus
0.666 0.334 0.000
A33 Tetanus neonatorum
0.666 0.334 0.000
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.666 0.334 0.000
D59.0 Drug-induced autoimmune haemolytic anaemia
0.664 0.336 0.000
G00.8 Other bacterial meningitis
0.663 0.337 0.000
G00.3 Staphylococcal meningitis
0.663 0.337 0.000
G00.0 Haemophilus meningitis
0.663 0.337 0.000
E58 Dietary calcium deficiency
0.663 0.337 0.000
M62.87 Other specified disorders of muscle (Ankle and foot)
0.662 0.338 0.000
M62.84 Other specified disorders of muscle (Hand)
0.662 0.338 0.000
A40.8 Other streptococcal septicaemia
0.662 0.338 0.000
M86.6 Other chronic osteomyelitis
0.660 0.340 0.000
D58 Other hereditary haemolytic anaemias
0.660 0.340 0.000
M43.9 Deforming dorsopathy, unspecified
0.660 0.340 0.000
H30.2 Posterior cyclitis
0.659 0.341 0.000
M60.8 Other myositis
0.659 0.341 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.657 0.343 0.000
M21.7 Unequal limb length (acquired)
0.657 0.343 0.000
K73.1 Chronic lobular hepatitis, not elsewhere classified
0.657 0.343 0.000
K73.0 Chronic persistent hepatitis, not elsewhere classified
0.657 0.343 0.000
M43.1 Spondylolisthesis
0.657 0.343 0.000
I20.8 Other forms of angina pectoris
0.000 0.343 0.657
B01.2 Varicella pneumonia
0.656 0.344 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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