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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs6916394
log Bayes Factor = 61.9927
Chromosome 6   position 31,464,050  (GRCh37) Explore rs6916394 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
1.000 0.000 0.000
M45 Ankylosing spondylitis
0.999 0.001 0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.998 0.002 0.000
E10 Insulin-dependent diabetes mellitus
0.000 0.005 0.995
R31 Unspecified haematuria
0.994 0.006 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.013 0.987
E05.9 Thyrotoxicosis, unspecified
0.000 0.015 0.985
E10-E14 Diabetes mellitus
0.000 0.017 0.983
E00-E07 Disorders of thyroid gland
0.000 0.023 0.977
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.023 0.977
E10.2 With renal complications
0.000 0.030 0.970
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.032 0.968
E10.9 Without complications
0.000 0.033 0.967
M45.X2 Ankylosing spondylitis (Cervical region)
0.951 0.049 0.000
I25 Chronic ischaemic heart disease
0.949 0.051 0.000
I20-I25 Ischaemic heart diseases
0.947 0.053 0.000
I20 Angina pectoris
0.945 0.055 0.000
I25.1 Atherosclerotic heart disease
0.943 0.057 0.000
I20.0 Unstable angina
0.937 0.063 0.000
G35 Multiple sclerosis
0.000 0.064 0.936
E10.1 With ketoacidosis
0.000 0.066 0.934
E10.3 With ophthalmic complications
0.000 0.069 0.931
K90 Intestinal malabsorption
0.000 0.073 0.927
I24 Other acute ischaemic heart diseases
0.920 0.080 0.000
K90.9 Intestinal malabsorption, unspecified
0.000 0.093 0.907
E20-E35 Disorders of other endocrine glands
0.000 0.110 0.890
E10.4 With neurological complications
0.000 0.113 0.887
E27 Other disorders of adrenal gland
0.000 0.114 0.886
I20.9 Angina pectoris, unspecified
0.886 0.114 0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.883 0.117 0.000
E50-E64 Other nutritional deficiencies
0.000 0.125 0.875
E27.1 Primary adrenocortical insufficiency
0.000 0.128 0.872
E10.8 With unspecified complications
0.000 0.137 0.863
I25.5 Ischaemic cardiomyopathy
0.861 0.139 0.000
I25.9 Chronic ischaemic heart disease, unspecified
0.854 0.146 0.000
I20.1 Angina pectoris with documented spasm
0.845 0.155 0.000
E05.8 Other thyrotoxicosis
0.000 0.156 0.844
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.157 0.843
M45.X6 Ankylosing spondylitis (Lumbar region)
0.843 0.157 0.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.173 0.827
G37 Other demyelinating diseases of central nervous system
0.000 0.174 0.826
I24.8 Other forms of acute ischaemic heart disease
0.825 0.175 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.182 0.818
E10.5 With peripheral circulatory complications
0.000 0.203 0.797
E06 Thyroiditis
0.000 0.203 0.797
I25.2 Old myocardial infarction
0.797 0.203 0.000
E11.5 With peripheral circulatory complications
0.000 0.204 0.796
E27.8 Other specified disorders of adrenal gland
0.000 0.221 0.779
E10.6 With other specified complications
0.000 0.222 0.778
E61 Deficiency of other nutrient elements
0.000 0.222 0.778
E53 Deficiency of other B group vitamins
0.000 0.225 0.775
I23 Certain current complications following acute myocardial infarction
0.762 0.238 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.245 0.755
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.260 0.740
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.262 0.738
E34 Other endocrine disorders
0.000 0.281 0.719
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.281 0.718
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.716 0.283 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.716 0.283 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.716 0.283 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.716 0.283 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.716 0.283 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.716 0.283 0.000
E20 Hypoparathyroidism
0.000 0.284 0.716
E10.7 With multiple complications
0.000 0.286 0.713
E27.2 Addisonian crisis
0.000 0.291 0.709
E05.5 Thyroid crisis or storm
0.000 0.292 0.707
E05.4 Thyrotoxicosis factitia
0.000 0.292 0.707
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.292 0.707
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.292 0.707
E06.9 Thyroiditis, unspecified
0.000 0.293 0.707
E12 Malnutrition-related diabetes mellitus
0.000 0.295 0.705
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.299 0.701
E00 Congenital iodine-deficiency syndrome
0.000 0.299 0.701
I25.6 Silent myocardial ischaemia
0.694 0.305 0.000
E07 Other disorders of thyroid
0.000 0.306 0.694
I25.8 Other forms of chronic ischaemic heart disease
0.693 0.307 0.000
E61.1 Iron deficiency
0.000 0.315 0.685
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.316 0.684
I25.4 Coronary artery aneurysm
0.683 0.317 0.000
E53.8 Deficiency of other specified B group vitamins
0.000 0.322 0.678
I24.9 Acute ischaemic heart disease, unspecified
0.667 0.333 0.000
K90.3 Pancreatic steatorrhoea
0.000 0.335 0.665
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.335 0.665
K90.1 Tropical sprue
0.000 0.335 0.665
E11.4 With neurological complications
0.000 0.336 0.664
E40-E46 Malnutrition
0.000 0.342 0.658
K90.8 Other intestinal malabsorption
0.000 0.350 0.649
E11.6 With other specified complications
0.000 0.353 0.647
E11.1 With ketoacidosis
0.000 0.356 0.644
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.362 0.638
E32 Diseases of thymus
0.000 0.362 0.638
E31 Polyglandular dysfunction
0.000 0.362 0.638
E30 Disorders of puberty, not elsewhere classified
0.000 0.362 0.638
E51 Thiamine deficiency
0.000 0.363 0.637
E27.5 Adrenomedullary hyperfunction
0.000 0.365 0.635
E27.0 Other adrenocortical overactivity
0.000 0.365 0.635
E25 Adrenogenital disorders
0.000 0.369 0.631
E11.3 With ophthalmic complications
0.000 0.370 0.630
I23.8 Other current complications following acute myocardial infarction
0.629 0.371 0.000
E10.0 With coma
0.000 0.372 0.628
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.373 0.627
E63 Other nutritional deficiencies
0.000 0.373 0.627
E50 Vitamin A deficiency
0.000 0.373 0.627
E60 Dietary zinc deficiency
0.000 0.373 0.627
E59 Dietary selenium deficiency
0.000 0.373 0.627
E54 Ascorbic acid deficiency
0.000 0.373 0.627
E52 Niacin deficiency [pellagra]
0.000 0.373 0.627
I25.3 Aneurysm of heart
0.626 0.374 0.000
E61.2 Magnesium deficiency
0.000 0.386 0.614
E53.9 Vitamin B deficiency, unspecified
0.000 0.386 0.614
E14 Unspecified diabetes mellitus
0.000 0.394 0.606
E34.9 Endocrine disorder, unspecified
0.000 0.396 0.604
E56 Other vitamin deficiencies
0.000 0.401 0.599
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.402 0.598
E11.7 With multiple complications
0.000 0.407 0.593
G37.5 Concentric sclerosis [Balo]
0.000 0.407 0.592
G37.4 Subacute necrotising myelitis
0.000 0.407 0.592
G37.2 Central pontine myelinolysis
0.000 0.407 0.592
G37.1 Central demyelination of corpus callosum
0.000 0.407 0.592
G37.0 Diffuse sclerosis
0.000 0.407 0.592
E20.9 Hypoparathyroidism, unspecified
0.000 0.409 0.591
G36 Other acute disseminated demyelination
0.000 0.412 0.588
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.427 0.573
E06.4 Drug-induced thyroiditis
0.000 0.428 0.572
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.428 0.572
E06.1 Subacute thyroiditis
0.000 0.428 0.572
E06.0 Acute thyroiditis
0.000 0.428 0.572
E11.8 With unspecified complications
0.000 0.430 0.570
E58 Dietary calcium deficiency
0.000 0.436 0.564
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.437 0.563
E61.9 Deficiency of nutrient element, unspecified
0.000 0.442 0.558
E61.8 Deficiency of other specified nutrient elements
0.000 0.442 0.558
E61.7 Deficiency of multiple nutrient elements
0.000 0.442 0.558
E61.6 Vanadium deficiency
0.000 0.442 0.558
E61.5 Molybdenum deficiency
0.000 0.442 0.558
E61.4 Chromium deficiency
0.000 0.442 0.558
E61.3 Manganese deficiency
0.000 0.442 0.558
E61.0 Copper deficiency
0.000 0.442 0.558
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.443 0.557
E53.1 Pyridoxine deficiency
0.000 0.444 0.556
E53.0 Riboflavin deficiency
0.000 0.444 0.556
E27.9 Disorder of adrenal gland, unspecified
0.000 0.451 0.549
E26 Hyperaldosteronism
0.000 0.454 0.546
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.546 0.454 0.000
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.546 0.454 0.000
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.546 0.454 0.000
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.546 0.454 0.000
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.546 0.454 0.000
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.546 0.454 0.000
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.546 0.454 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.454 0.546
I24.1 Dressler's syndrome
0.545 0.455 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.541 0.459 0.000
E29 Testicular dysfunction
0.000 0.464 0.536
E07.9 Disorder of thyroid, unspecified
0.000 0.465 0.535
E06.5 Other chronic thyroiditis
0.000 0.466 0.534
E55 Vitamin D deficiency
0.000 0.469 0.531
E21.0 Primary hyperparathyroidism
0.000 0.477 0.523
E06.3 Autoimmune thyroiditis
0.000 0.480 0.520
E34.5 Androgen resistance syndrome
0.000 0.484 0.516
E34.4 Constitutional tall stature
0.000 0.484 0.516
E34.3 Short stature, not elsewhere classified
0.000 0.484 0.516
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.484 0.516
E34.1 Other hypersecretion of intestinal hormones
0.000 0.484 0.516
E34.0 Carcinoid syndrome
0.000 0.485 0.515
E20.8 Other hypoparathyroidism
0.000 0.487 0.513
E20.1 Pseudohypoparathyroidism
0.000 0.487 0.513
E20.0 Idiopathic hypoparathyroidism
0.000 0.487 0.513
E24 Cushing's syndrome
0.000 0.488 0.512
E12.9 Without complications
0.000 0.494 0.505
E12.8 With unspecified complications
0.000 0.494 0.505
E12.7 With multiple complications
0.000 0.494 0.505
E12.6 With other specified complications
0.000 0.494 0.505
E12.5 With peripheral circulatory complications
0.000 0.494 0.505
E12.4 With neurological complications
0.000 0.494 0.505
E12.3 With ophthalmic complications
0.000 0.494 0.505
E12.2 With renal complications
0.000 0.494 0.505
E12.1 With ketoacidosis
0.000 0.494 0.505
E12.0 With coma
0.000 0.494 0.505
E34.8 Other specified endocrine disorders
0.000 0.495 0.504
I22 Subsequent myocardial infarction
0.503 0.497 0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.497 0.502
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.497 0.502
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.497 0.502
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.497 0.502
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.497 0.502
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.497 0.502
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.497 0.502
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.497 0.502
E13 Other specified diabetes mellitus
0.000 0.500 0.500
E07.1 Dyshormogenetic goitre
0.000 0.502 0.498
E07.0 Hypersecretion of calcitonin
0.000 0.502 0.498
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.503 0.497
E21.4 Other specified disorders of parathyroid gland
0.000 0.509 0.491
E14.1 With ketoacidosis
0.000 0.517 0.483
E14.3 With ophthalmic complications
0.000 0.522 0.478
E14.5 With peripheral circulatory complications
0.000 0.527 0.473
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.528 0.472
E45 Retarded development following protein-energy malnutrition
0.000 0.528 0.472
E43 Unspecified severe protein-energy malnutrition
0.000 0.528 0.472
E42 Marasmic kwashiorkor
0.000 0.528 0.472
E41 Nutritional marasmus
0.000 0.528 0.472
E40 Kwashiorkor
0.000 0.528 0.472
E21.2 Other hyperparathyroidism
0.000 0.533 0.467
E51.2 Wernicke's encephalopathy
0.000 0.533 0.467
E11.2 With renal complications
0.000 0.540 0.460
E30.9 Disorder of puberty, unspecified
0.000 0.542 0.457
E30.8 Other disorders of puberty
0.000 0.542 0.457
E30.1 Precocious puberty
0.000 0.542 0.457
E30.0 Delayed puberty
0.000 0.542 0.457
E31.9 Polyglandular dysfunction, unspecified
0.000 0.542 0.457
E31.8 Other polyglandular dysfunction
0.000 0.542 0.457
E31.1 Polyglandular hyperfunction
0.000 0.542 0.457
E31.0 Autoimmune polyglandular failure
0.000 0.542 0.457
E32.9 Disease of thymus, unspecified
0.000 0.542 0.457
E32.8 Other diseases of thymus
0.000 0.542 0.457
E32.1 Abscess of thymus
0.000 0.542 0.457
E32.0 Persistent hyperplasia of thymus
0.000 0.542 0.457
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.542 0.457
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.542 0.457
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.542 0.457
E51.9 Thiamine deficiency, unspecified
0.000 0.543 0.457
E51.8 Other manifestations of thiamine deficiency
0.000 0.543 0.457
E51.1 Beriberi
0.000 0.543 0.457
I22.1 Subsequent myocardial infarction of inferior wall
0.456 0.544 0.000
E25.9 Adrenogenital disorder, unspecified
0.000 0.547 0.452
E25.8 Other adrenogenital disorders
0.000 0.547 0.452
E50.9 Vitamin A deficiency, unspecified
0.000 0.550 0.450
E50.8 Other manifestations of vitamin A deficiency
0.000 0.550 0.450
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.550 0.450
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.550 0.450
E50.5 Vitamin A deficiency with night blindness
0.000 0.550 0.450
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.550 0.450
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.550 0.450
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.550 0.450
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.550 0.450
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.550 0.450
E63.9 Nutritional deficiency, unspecified
0.000 0.550 0.450
E63.8 Other specified nutritional deficiencies
0.000 0.550 0.450
E63.1 Imbalance of constituents of food intake
0.000 0.550 0.450
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.550 0.450
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.550 0.450
E64.8 Sequelae of other nutritional deficiencies
0.000 0.550 0.450
E64.3 Sequelae of rickets
0.000 0.550 0.450
E64.2 Sequelae of vitamin C deficiency
0.000 0.550 0.450
E64.1 Sequelae of vitamin A deficiency
0.000 0.550 0.450
E64.0 Sequelae of protein-energy malnutrition
0.000 0.550 0.450
M25.55 Pain in joint (Pelvic region and thigh)
0.000 0.550 0.450
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.554 0.445
E07.8 Other specified disorders of thyroid
0.000 0.555 0.445
E14.8 With unspecified complications
0.000 0.555 0.445
M25.5 Pain in joint
0.000 0.557 0.443
M25.54 Pain in joint (Hand)
0.000 0.560 0.440
I21 Acute myocardial infarction
0.440 0.560 0.000
E14.7 With multiple complications
0.000 0.566 0.434
E14.2 Withrenal complications
0.000 0.566 0.434
E14.0 With coma
0.000 0.566 0.434
E14.6 With other specified complications
0.000 0.569 0.431
E56.9 Vitamin deficiency, unspecified
0.000 0.570 0.430
E56.8 Deficiency of other vitamins
0.000 0.570 0.430
E56.0 Deficiency of vitamin E
0.000 0.570 0.430
E46 Unspecified protein-energy malnutrition
0.000 0.570 0.430
I21.2 Acute transmural myocardial infarction of other sites
0.426 0.574 0.000
G36.9 Acute disseminated demyelination, unspecified
0.000 0.578 0.422
G36.8 Other specified acute disseminated demyelination
0.000 0.578 0.422
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.578 0.422
M25 Other joint disorders, not elsewhere classified
0.000 0.588 0.412
E14.4 With neurological complications
0.000 0.594 0.406
G36.0 Neuromyelitis optica [Devic]
0.000 0.594 0.405
M25.6 Stiffness of joint, not elsewhere classified
0.000 0.595 0.405
M25.7 Osteophyte
0.000 0.597 0.403
E56.1 Deficiency of vitamin K
0.000 0.598 0.402
E21.3 Hyperparathyroidism, unspecified
0.000 0.600 0.400
M25.53 Pain in joint (Forearm)
0.000 0.600 0.400
E28 Ovarian dysfunction
0.000 0.606 0.394
E26.9 Hyperaldosteronism, unspecified
0.000 0.608 0.392
E26.8 Other hyperaldosteronism
0.000 0.608 0.392
E26.1 Secondary hyperaldosteronism
0.000 0.608 0.392
E15 Nondiabetic hypoglycaemic coma
0.000 0.609 0.391
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)
0.000 0.612 0.388
E29.9 Testicular dysfunction, unspecified
0.000 0.615 0.385
E29.8 Other testicular dysfunction
0.000 0.615 0.385
E29.0 Testicular hyperfunction
0.000 0.615 0.385
E55.0 Rickets, active
0.000 0.619 0.381
E11.0 With coma
0.000 0.630 0.370
M25.58 Pain in joint (Other)
0.000 0.630 0.370
E24.8 Other Cushing's syndrome
0.000 0.633 0.367
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.633 0.367
E24.3 Ectopic ACTH syndrome
0.000 0.633 0.367
E24.1 Nelson's syndrome
0.000 0.633 0.367
M25.71 Osteophyte (Shoulder region)
0.000 0.636 0.364
M25.64 Stiffness of joint, not elsewhere classified (Hand)
0.000 0.638 0.362
M25.77 Osteophyte (Ankle and foot)
0.000 0.640 0.360
M25.76 Osteophyte (Lower leg)
0.000 0.640 0.360
E13.8 With unspecified complications
0.000 0.641 0.358
E13.7 With multiple complications
0.000 0.641 0.358
E13.6 With other specified complications
0.000 0.641 0.358
E13.5 With peripheral circulatory complications
0.000 0.641 0.358
E13.4 With neurological complications
0.000 0.641 0.358
E13.2 With renal complications
0.000 0.641 0.358
E13.1 With ketoacidosis
0.000 0.641 0.358
E13.0 With coma
0.000 0.641 0.358
E24.0 Pituitary-dependent Cushing's disease
0.000 0.647 0.353
E22 Hyperfunction of pituitary gland
0.000 0.655 0.345
E65-E68 Obesity and other hyperalimentation
0.000 0.655 0.345
E13.3 With ophthalmic complications
0.000 0.657 0.343
M25.9 Joint disorder, unspecified
0.000 0.660 0.340
E24.2 Drug-induced Cushing's syndrome
0.000 0.661 0.339
M25.72 Osteophyte (Upper arm)
0.000 0.661 0.339
E44.1 Mild protein-energy malnutrition
0.000 0.661 0.338
E44.0 Moderate protein-energy malnutrition
0.000 0.661 0.338
M25.68 Stiffness of joint, not elsewhere classified (Other)
0.000 0.671 0.329
M25.52 Pain in joint (Upper arm)
0.000 0.674 0.326
I21.9 Acute myocardial infarction, unspecified
0.324 0.676 0.000
M25.0 Haemarthrosis
0.000 0.684 0.316
I21.X Presumed acute myicardial infaction (unconfirmed)
0.315 0.684 0.000
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)
0.000 0.690 0.310
M25.74 Osteophyte (Hand)
0.000 0.691 0.309
M25.73 Osteophyte (Forearm)
0.000 0.692 0.308
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)
0.000 0.694 0.306
E24.9 Cushing's syndrome, unspecified
0.000 0.695 0.305
M25.79 Osteophyte (Site unspecified)
0.000 0.698 0.302
E26.0 Primary hyperaldosteronism
0.000 0.700 0.300
M25.96 Joint disorder, unspecified (Lower leg)
0.000 0.703 0.297
M25.2 Flail joint
0.000 0.704 0.296
M25.1 Fistula of joint
0.000 0.704 0.296
R30.0 Dysuria
0.294 0.706 0.000
R30-R39 Symptoms and signs involving the urinary system
0.293 0.707 0.000
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)
0.000 0.710 0.290
R30 Pain associated with micturition
0.290 0.710 0.000
I22.8 Subsequent myocardial infarction of other sites
0.290 0.710 0.000
M25.70 Osteophyte (Multiple sites)
0.000 0.711 0.289
M25.57 Pain in joint (Ankle and foot)
0.000 0.713 0.287
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)
0.000 0.714 0.286
E55.9 Vitamin D deficiency, unspecified
0.000 0.715 0.285
M25.63 Stiffness of joint, not elsewhere classified (Forearm)
0.000 0.717 0.283
E28.9 Ovarian dysfunction, unspecified
0.000 0.717 0.283
E28.8 Other ovarian dysfunction
0.000 0.717 0.283
E28.1 Androgen excess
0.000 0.717 0.283
E28.0 Oestrogen excess
0.000 0.717 0.283
E29.1 Testicular hypofunction
0.000 0.717 0.283
E23 Hypofunction and other disorders of pituitary gland
0.000 0.723 0.276
M25.50 Pain in joint (Multiple sites)
0.000 0.728 0.272
M25.91 Joint disorder, unspecified (Shoulder region)
0.000 0.729 0.271
R34 Anuria and oliguria
0.269 0.731 0.000
E03 Other hypothyroidism
0.000 0.739 0.261
E28.3 Primary ovarian failure
0.000 0.743 0.257
M25.94 Joint disorder, unspecified (Hand)
0.000 0.743 0.257
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)
0.000 0.743 0.257
M25.06 Haemarthrosis (Lower leg)
0.000 0.752 0.248
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.752 0.248
E22.8 Other hyperfunction of pituitary gland
0.000 0.752 0.248
E67 Other hyperalimentation
0.000 0.753 0.247
E68 Sequelae of hyperalimentation
0.000 0.753 0.247
M25.59 Pain in joint (Site unspecified)
0.000 0.756 0.244
M25.98 Joint disorder, unspecified (Other)
0.000 0.756 0.244
M25.92 Joint disorder, unspecified (Upper arm)
0.000 0.756 0.244
M25.90 Joint disorder, unspecified (Multiple sites)
0.000 0.756 0.244
I21.3 Acute transmural myocardial infarction of unspecified site
0.244 0.756 0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)
0.000 0.758 0.242
M25.78 Osteophyte (Other)
0.000 0.760 0.240
E16 Other disorders of pancreatic internal secretion
0.000 0.763 0.237
M25.99 Joint disorder, unspecified (Site unspecified)
0.000 0.766 0.234
M25.93 Joint disorder, unspecified (Forearm)
0.000 0.767 0.233
I22.0 Subsequent myocardial infarction of anterior wall
0.229 0.770 0.000
M25.95 Joint disorder, unspecified (Pelvic region and thigh)
0.000 0.770 0.229
M25.09 Haemarthrosis (Site unspecified)
0.000 0.773 0.227
M25.08 Haemarthrosis (Other)
0.000 0.773 0.227
M25.07 Haemarthrosis (Ankle and foot)
0.000 0.773 0.227
M25.05 Haemarthrosis (Pelvic region and thigh)
0.000 0.773 0.227
M25.04 Haemarthrosis (Hand)
0.000 0.773 0.227
M25.03 Haemarthrosis (Forearm)
0.000 0.773 0.227
M25.02 Haemarthrosis (Upper arm)
0.000 0.773 0.227
M25.01 Haemarthrosis (Shoulder region)
0.000 0.773 0.227
M25.00 Haemarthrosis (Multiple sites)
0.000 0.773 0.227
E22.1 Hyperprolactinaemia
0.000 0.786 0.213
R30.1 Vesical tenesmus
0.212 0.787 0.000
M25.19 Fistula of joint (Site unspecified)
0.000 0.788 0.212
M25.18 Fistula of joint (Other)
0.000 0.788 0.212
M25.17 Fistula of joint (Ankle and foot)
0.000 0.788 0.212
M25.16 Fistula of joint (Lower leg)
0.000 0.788 0.212
M25.15 Fistula of joint (Pelvic region and thigh)
0.000 0.788 0.212
M25.14 Fistula of joint (Hand)
0.000 0.788 0.212
M25.13 Fistula of joint (Forearm)
0.000 0.788 0.212
M25.12 Fistula of joint (Upper arm)
0.000 0.788 0.212
M25.11 Fistula of joint (Shoulder region)
0.000 0.788 0.212
M25.10 Fistula of joint (Multiple sites)
0.000 0.788 0.212
M25.29 Flail joint (Site unspecified)
0.000 0.788 0.212
M25.28 Flail joint (Other)
0.000 0.788 0.212
M25.27 Flail joint (Ankle and foot)
0.000 0.788 0.212
M25.26 Flail joint (Lower leg)
0.000 0.788 0.212
M25.25 Flail joint (Pelvic region and thigh)
0.000 0.788 0.212
M25.24 Flail joint (Hand)
0.000 0.788 0.212
M25.23 Flail joint (Forearm)
0.000 0.788 0.212
M25.22 Flail joint (Upper arm)
0.000 0.788 0.212
M25.21 Flail joint (Shoulder region)
0.000 0.788 0.212
M25.20 Flail joint (Multiple sites)
0.000 0.788 0.212
E23.7 Disorder of pituitary gland, unspecified
0.000 0.792 0.208
M25.97 Joint disorder, unspecified (Ankle and foot)
0.000 0.795 0.205
I20.8 Other forms of angina pectoris
0.199 0.801 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.801 0.198
E23.1 Drug-induced hypopituitarism
0.000 0.801 0.198
R36 Urethral discharge
0.194 0.805 0.000
E13.9 Without complications
0.001 0.811 0.189
E03.5 Myxoedema coma
0.000 0.812 0.187
E03.4 Atrophy of thyroid (acquired)
0.000 0.812 0.187
E03.3 Postinfectious hypothyroidism
0.000 0.812 0.187
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.812 0.187
E22.0 Acromegaly and pituitary gigantism
0.000 0.813 0.187
E03.1 Congenital hypothyroidism without goitre
0.000 0.816 0.183
E67.8 Other specified hyperalimentation
0.000 0.822 0.177
E67.3 Hypervitaminosis D
0.000 0.822 0.177
E67.2 Megavitamin-B6 syndrome
0.000 0.822 0.177
E67.1 Hypercarotenaemia
0.000 0.822 0.177
E67.0 Hypervitaminosis A
0.000 0.822 0.177
E65 Localised adiposity
0.000 0.825 0.175
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.830 0.170
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.830 0.170
E16.4 Abnormal secretion of gastrin
0.000 0.830 0.170
E16.3 Increased secretion of glucagon
0.000 0.830 0.170
E03.8 Other specified hypothyroidism
0.000 0.831 0.169
I22.9 Subsequent myocardial infarction of unspecified site
0.168 0.831 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.833 0.167
E23.2 Diabetes insipidus
0.000 0.834 0.166
E04 Other non-toxic goitre
0.000 0.837 0.163
M25.3 Other instability of joint
0.000 0.843 0.157
I21.0 Acute transmural myocardial infarction of anterior wall
0.154 0.846 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.001 0.849 0.150
I21.1 Acute transmural myocardial infarction of inferior wall
0.146 0.854 0.000
E16.1 Other hypoglycaemia
0.000 0.855 0.145
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.859 0.141
M25.8 Other specified joint disorders
0.000 0.864 0.136
R30.9 Painful micturition, unspecified
0.133 0.866 0.000
E11.9 Without complications
0.000 0.874 0.126
E16.2 Hypoglycaemia, unspecified
0.000 0.876 0.124
C71 Malignant neoplasm of brain
0.121 0.879 0.000
E04.0 Non-toxic diffuse goitre
0.000 0.879 0.120
C71.9 Brain, unspecified
0.119 0.881 0.000
C71.2 Temporal lobe
0.118 0.882 0.000
E04.8 Other specified non-toxic goitre
0.000 0.883 0.117
E23.6 Other disorders of pituitary gland
0.001 0.883 0.116
C71.0 Cerebrum, except lobes and ventricles
0.116 0.884 0.000
M25.31 Other instability of joint (Shoulder region)
0.000 0.884 0.115
M25.39 Other instability of joint (Site unspecified)
0.000 0.887 0.113
M25.38 Other instability of joint (Other)
0.000 0.887 0.113
M25.35 Other instability of joint (Pelvic region and thigh)
0.000 0.887 0.113
M25.32 Other instability of joint (Upper arm)
0.000 0.887 0.113
M25.30 Other instability of joint (Multiple sites)
0.000 0.887 0.113
M25.37 Other instability of joint (Ankle and foot)
0.000 0.893 0.107
E28.2 Polycystic ovarian syndrome
0.001 0.894 0.105
C71.3 Parietal lobe
0.104 0.896 0.000
E23.0 Hypopituitarism
0.000 0.896 0.103
M25.33 Other instability of joint (Forearm)
0.000 0.898 0.102
M25.84 Other specified joint disorders (Hand)
0.000 0.898 0.102
M25.89 Other specified joint disorders (Site unspecified)
0.000 0.902 0.097
M25.82 Other specified joint disorders (Upper arm)
0.000 0.902 0.097
M25.80 Other specified joint disorders (Multiple sites)
0.000 0.902 0.097
M25.86 Other specified joint disorders (Lower leg)
0.000 0.905 0.095
M25.85 Other specified joint disorders (Pelvic region and thigh)
0.000 0.906 0.094
R39 Other symptoms and signs involving the urinary system
0.093 0.907 0.000
M25.75 Osteophyte (Pelvic region and thigh)
0.000 0.910 0.090
M25.83 Other specified joint disorders (Forearm)
0.000 0.910 0.089
C71.8 Overlapping lesion of brain
0.088 0.912 0.000
C71.7 Brain stem
0.087 0.913 0.000
C71.6 Cerebellum
0.087 0.913 0.000
C71.5 Cerebral ventricle
0.087 0.913 0.000
E66 Obesity
0.000 0.916 0.084
C71.4 Occipital lobe
0.082 0.918 0.000
M25.34 Other instability of joint (Hand)
0.001 0.920 0.080
M25.87 Other specified joint disorders (Ankle and foot)
0.000 0.920 0.080
M25.36 Other instability of joint (Lower leg)
0.001 0.921 0.079
M25.51 Pain in joint (Shoulder region)
0.000 0.925 0.075
C71.1 Frontal lobe
0.074 0.926 0.000
M25.81 Other specified joint disorders (Shoulder region)
0.000 0.928 0.071
M25.88 Other specified joint disorders (Other)
0.000 0.929 0.071
E04.2 Non-toxic multinodular goitre
0.000 0.932 0.068
R39.2 Extrarenal uraemia
0.067 0.933 0.000
K90-K93 Other diseases of the digestive system
0.000 0.933 0.067
I21.4 Acute subendocardial myocardial infarction
0.063 0.937 0.000
R39.0 Extravasation of urine
0.063 0.937 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.938 0.062
M45-M49 Spondylopathies
0.061 0.939 0.000
E66.1 Drug-induced obesity
0.000 0.939 0.061
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.057 0.943 0.000
H20.9 Iridocyclitis, unspecified
0.057 0.943 0.000
R39.8 Other and unspecified symptoms and signs involving the urinary system
0.056 0.944 0.000
N93.8 Other specified abnormal uterine and vaginal bleeding
0.000 0.945 0.055
S02.40 Fracture of malar and maxillary bones (closed)
0.000 0.948 0.052
E66.8 Other obesity
0.000 0.950 0.050
R32 Unspecified urinary incontinence
0.049 0.951 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.952 0.048
C69 Malignant neoplasm of eye and adnexa
0.046 0.954 0.000
E66.0 Obesity due to excess calories
0.000 0.955 0.045
M25.4 Effusion of joint
0.000 0.955 0.045
E04.9 Non-toxic goitre, unspecified
0.000 0.955 0.045
E04.1 Non-toxic single thyroid nodule
0.000 0.957 0.043
C70 Malignant neoplasm of meninges
0.043 0.957 0.000
M49 Spondylopathies in diseases classified elsewhere
0.042 0.958 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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