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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs739496
log Bayes Factor = 22.8103
Chromosome 12   position 111,887,659  (GRCh37) Explore rs739496 on Ensembl!
Variant rs739496 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
I10 Essential (primary) hypertension
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
I21 Acute myocardial infarction
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.000 1.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.001 0.999
I25.1 Atherosclerotic heart disease
0.000 0.001 0.999
E00-E07 Disorders of thyroid gland
0.000 0.001 0.999
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.003 0.997
E20-E35 Disorders of other endocrine glands
0.000 0.003 0.997
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.005 0.995
I10-I15 Hypertensive diseases
0.000 0.006 0.994
Chapter IX Diseases of the circulatory system
0.000 0.006 0.994
E27 Other disorders of adrenal gland
0.000 0.008 0.992
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.011 0.989
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.011 0.989
Z95.1 Presence of aortocoronary bypass graft
0.000 0.013 0.987
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.018 0.982
E05.9 Thyrotoxicosis, unspecified
0.000 0.024 0.976
E27.1 Primary adrenocortical insufficiency
0.000 0.033 0.967
I22 Subsequent myocardial infarction
0.000 0.036 0.964
E10-E14 Diabetes mellitus
0.000 0.039 0.961
E10 Insulin-dependent diabetes mellitus
0.000 0.042 0.958
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.047 0.953
Z95.3 Presence of xenogenic heart valve
0.000 0.053 0.947
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.057 0.943
I30-I52 Other forms of heart disease
0.000 0.064 0.936
I25.5 Ischaemic cardiomyopathy
0.000 0.067 0.933
I49 Other cardiac arrhythmias
0.000 0.069 0.931
I49.9 Cardiac arrhythmia, unspecified
0.000 0.075 0.925
I35 Nonrheumatic aortic valve disorders
0.000 0.076 0.924
E10.3 With ophthalmic complications
0.000 0.080 0.920
E10.9 Without complications
0.000 0.085 0.915
I49.3 Ventricular premature depolarisation
0.000 0.089 0.911
I35.0 Aortic (valve) stenosis
0.000 0.090 0.910
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.094 0.906
E28 Ovarian dysfunction
0.000 0.096 0.904
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.100 0.900
E23 Hypofunction and other disorders of pituitary gland
0.000 0.102 0.898
I99 Other and unspecified disorders of circulatory system
0.000 0.117 0.883
I35.2 Aortic (valve) stenosis with insufficiency
0.000 0.118 0.882
E50-E64 Other nutritional deficiencies
0.000 0.118 0.882
I21.9 Acute myocardial infarction, unspecified
0.000 0.119 0.881
I47 Paroxysmal tachycardia
0.000 0.121 0.879
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.134 0.866
I47.2 Ventricular tachycardia
0.000 0.143 0.857
I20 Angina pectoris
0.000 0.148 0.852
I25.2 Old myocardial infarction
0.000 0.153 0.847
Z95.2 Presence of prosthetic heart valve
0.000 0.159 0.841
E27.8 Other specified disorders of adrenal gland
0.000 0.160 0.840
I20.8 Other forms of angina pectoris
0.000 0.160 0.840
E21.0 Primary hyperparathyroidism
0.000 0.167 0.833
I42 Cardiomyopathy
0.000 0.171 0.829
I97.1 Other functional disturbances following cardiac surgery
0.000 0.177 0.823
E23.2 Diabetes insipidus
0.000 0.183 0.817
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.185 0.815
E28.2 Polycystic ovarian syndrome
0.000 0.186 0.814
E22 Hyperfunction of pituitary gland
0.000 0.190 0.810
E34 Other endocrine disorders
0.000 0.207 0.793
E06 Thyroiditis
0.000 0.210 0.790
I23 Certain current complications following acute myocardial infarction
0.000 0.213 0.787
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.217 0.783
E27.2 Addisonian crisis
0.000 0.218 0.782
E10.5 With peripheral circulatory complications
0.000 0.219 0.781
E10.4 With neurological complications
0.000 0.219 0.781
Z95.4 Presence of other heart-valve replacement
0.000 0.224 0.776
Z95.8 Presence of other cardiac and vascular implants and grafts
0.000 0.224 0.776
E10.0 With coma
0.000 0.226 0.774
I47.9 Paroxysmal tachycardia, unspecified
0.000 0.227 0.773
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.232 0.768
I97.2 Postmastectomy lymphoedema syndrome
0.000 0.239 0.761
I50 Heart failure
0.000 0.240 0.760
I49.0 Ventricular fibrillation and flutter
0.000 0.244 0.756
E61 Deficiency of other nutrient elements
0.000 0.245 0.755
E03.8 Other specified hypothyroidism
0.000 0.250 0.750
I24 Other acute ischaemic heart diseases
0.000 0.255 0.745
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.257 0.743
I25.4 Coronary artery aneurysm
0.000 0.259 0.741
E53 Deficiency of other B group vitamins
0.000 0.263 0.736
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.267 0.733
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.267 0.733
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.269 0.731
I42.9 Cardiomyopathy, unspecified
0.000 0.270 0.730
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.277 0.723
I98 Other disorders of circulatory system in diseases classified elsewhere
0.000 0.279 0.721
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.282 0.718
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.284 0.716
E03.4 Atrophy of thyroid (acquired)
0.000 0.284 0.716
E03.3 Postinfectious hypothyroidism
0.000 0.284 0.716
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.284 0.716
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.284 0.716
E00 Congenital iodine-deficiency syndrome
0.000 0.284 0.716
E28.3 Primary ovarian failure
0.000 0.285 0.715
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.285 0.714
E32 Diseases of thymus
0.000 0.285 0.714
E31 Polyglandular dysfunction
0.000 0.285 0.714
E30 Disorders of puberty, not elsewhere classified
0.000 0.285 0.714
I13 Hypertensive heart and renal disease
0.000 0.287 0.713
E23.6 Other disorders of pituitary gland
0.000 0.287 0.712
I00-I02 Acute rheumatic fever
0.000 0.287 0.712
E27.5 Adrenomedullary hyperfunction
0.000 0.289 0.711
E27.0 Other adrenocortical overactivity
0.000 0.289 0.711
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.290 0.710
E10.2 With renal complications
0.000 0.295 0.705
E05.5 Thyroid crisis or storm
0.000 0.296 0.704
E05.4 Thyrotoxicosis factitia
0.000 0.296 0.704
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.296 0.704
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.296 0.704
E10.8 With unspecified complications
0.000 0.297 0.703
I42.1 Obstructive hypertrophic cardiomyopathy
0.000 0.299 0.701
E27.9 Disorder of adrenal gland, unspecified
0.000 0.302 0.698
E10.6 With other specified complications
0.000 0.304 0.696
E06.9 Thyroiditis, unspecified
0.000 0.306 0.694
E20 Hypoparathyroidism
0.000 0.306 0.694
E12 Malnutrition-related diabetes mellitus
0.000 0.311 0.689
I25.3 Aneurysm of heart
0.000 0.312 0.688
E10.1 With ketoacidosis
0.000 0.313 0.687
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.320 0.680
E23.7 Disorder of pituitary gland, unspecified
0.000 0.323 0.677
I24.8 Other forms of acute ischaemic heart disease
0.000 0.323 0.677
I42.0 Dilated cardiomyopathy
0.000 0.327 0.673
I52 Other heart disorders in diseases classified elsewhere
0.000 0.329 0.671
I48 Atrial fibrillation and flutter
0.000 0.329 0.671
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.329 0.671
I41 Myocarditis in diseases classified elsewhere
0.000 0.329 0.671
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.329 0.671
I32 Pericarditis in diseases classified elsewhere
0.000 0.329 0.671
I22.8 Subsequent myocardial infarction of other sites
0.000 0.329 0.670
I49.2 Junctional premature depolarisation
0.000 0.332 0.668
I37 Pulmonary valve disorders
0.000 0.336 0.664
Z95.0 Presence of cardiac pacemaker
0.000 0.345 0.655
E25 Adrenogenital disorders
0.000 0.346 0.654
I97.9 Postprocedural disorder of circulatory system, unspecified
0.000 0.351 0.649
I97.0 Postcardiotomy syndrome
0.000 0.351 0.649
E28.9 Ovarian dysfunction, unspecified
0.000 0.352 0.648
E28.8 Other ovarian dysfunction
0.000 0.352 0.648
E28.1 Androgen excess
0.000 0.352 0.648
E28.0 Oestrogen excess
0.000 0.352 0.648
I50.1 Left ventricular failure
0.000 0.354 0.646
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.354 0.646
E21.4 Other specified disorders of parathyroid gland
0.000 0.355 0.645
E21.2 Other hyperparathyroidism
0.000 0.355 0.645
I33 Acute and subacute endocarditis
0.000 0.355 0.645
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.356 0.644
E23.1 Drug-induced hypopituitarism
0.000 0.356 0.644
E07 Other disorders of thyroid
0.000 0.361 0.639
E26 Hyperaldosteronism
0.000 0.365 0.635
I23.8 Other current complications following acute myocardial infarction
0.000 0.365 0.635
E34.9 Endocrine disorder, unspecified
0.000 0.367 0.633
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.367 0.632
E63 Other nutritional deficiencies
0.000 0.367 0.632
E56 Other vitamin deficiencies
0.000 0.367 0.632
E51 Thiamine deficiency
0.000 0.367 0.632
E50 Vitamin A deficiency
0.000 0.367 0.632
E60 Dietary zinc deficiency
0.000 0.367 0.632
E59 Dietary selenium deficiency
0.000 0.367 0.632
E58 Dietary calcium deficiency
0.000 0.367 0.632
E54 Ascorbic acid deficiency
0.000 0.367 0.632
E52 Niacin deficiency [pellagra]
0.000 0.367 0.632
E03.1 Congenital hypothyroidism without goitre
0.000 0.369 0.630
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.373 0.627
E05.8 Other thyrotoxicosis
0.000 0.373 0.626
E61.1 Iron deficiency
0.000 0.374 0.626
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.389 0.611
I42.2 Other hypertrophic cardiomyopathy
0.000 0.390 0.609
E55 Vitamin D deficiency
0.000 0.395 0.605
E53.8 Deficiency of other specified B group vitamins
0.000 0.395 0.605
E61.2 Magnesium deficiency
0.000 0.396 0.604
E34.0 Carcinoid syndrome
0.000 0.399 0.601
I21.4 Acute subendocardial myocardial infarction
0.000 0.399 0.601
E21.3 Hyperparathyroidism, unspecified
0.000 0.404 0.596
I42.5 Other restrictive cardiomyopathy
0.000 0.406 0.594
I42.4 Endocardial fibroelastosis
0.000 0.406 0.594
I42.3 Endomyocardial (eosinophilic) disease
0.000 0.406 0.594
I49.4 Other and unspecified premature depolarisation
0.000 0.408 0.592
E14 Unspecified diabetes mellitus
0.000 0.411 0.589
I50.9 Heart failure, unspecified
0.000 0.413 0.587
I11 Hypertensive heart disease
0.000 0.413 0.586
I35.8 Other aortic valve disorders
0.000 0.414 0.586
I42.6 Alcoholic cardiomyopathy
0.000 0.418 0.582
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.419 0.581
E22.8 Other hyperfunction of pituitary gland
0.000 0.419 0.581
I36 Nonrheumatic tricuspid valve disorders
0.000 0.420 0.580
I35.9 Aortic valve disorder, unspecified
0.000 0.424 0.576
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.429 0.571
E53.9 Vitamin B deficiency, unspecified
0.000 0.429 0.571
E22.1 Hyperprolactinaemia
0.000 0.429 0.570
E34.5 Androgen resistance syndrome
0.000 0.431 0.568
E34.4 Constitutional tall stature
0.000 0.431 0.568
E34.3 Short stature, not elsewhere classified
0.000 0.431 0.568
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.431 0.568
E34.1 Other hypersecretion of intestinal hormones
0.000 0.431 0.568
I47.0 Reentry ventricular arrhythmia
0.000 0.432 0.568
E06.4 Drug-induced thyroiditis
0.000 0.433 0.567
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.433 0.567
E06.1 Subacute thyroiditis
0.000 0.433 0.567
E06.0 Acute thyroiditis
0.000 0.433 0.567
I15 Secondary hypertension
0.000 0.435 0.564
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.435 0.564
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.435 0.564
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.435 0.564
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.435 0.564
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.435 0.564
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.435 0.564
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.435 0.564
E34.8 Other specified endocrine disorders
0.000 0.447 0.553
I24.1 Dressler's syndrome
0.000 0.448 0.552
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.000 0.448 0.552
E23.0 Hypopituitarism
0.000 0.448 0.552
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.450 0.550
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.000 0.453 0.547
E40-E46 Malnutrition
0.000 0.456 0.544
E61.9 Deficiency of nutrient element, unspecified
0.000 0.458 0.541
E61.8 Deficiency of other specified nutrient elements
0.000 0.458 0.541
E61.7 Deficiency of multiple nutrient elements
0.000 0.458 0.541
E61.6 Vanadium deficiency
0.000 0.458 0.541
E61.5 Molybdenum deficiency
0.000 0.458 0.541
E61.4 Chromium deficiency
0.000 0.458 0.541
E61.3 Manganese deficiency
0.000 0.458 0.541
E61.0 Copper deficiency
0.000 0.458 0.541
E16 Other disorders of pancreatic internal secretion
0.000 0.459 0.541
E24 Cushing's syndrome
0.000 0.461 0.539
E29 Testicular dysfunction
0.000 0.467 0.533
E06.3 Autoimmune thyroiditis
0.000 0.467 0.533
E53.1 Pyridoxine deficiency
0.000 0.472 0.528
E53.0 Riboflavin deficiency
0.000 0.472 0.528
I98.2 Oesophageal varices in diseases classified elsewhere
0.000 0.473 0.527
I40 Acute myocarditis
0.000 0.475 0.524
E15 Nondiabetic hypoglycaemic coma
0.000 0.476 0.524
E10.7 With multiple complications
0.000 0.479 0.521
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.000 0.483 0.517
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.483 0.517
I98.0 Cardiovascular syphilis
0.000 0.483 0.517
I49.5 Sick sinus syndrome
0.000 0.483 0.517
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.513
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.513
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.513
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.513
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.513
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.513
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.513
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.513
E30.9 Disorder of puberty, unspecified
0.000 0.487 0.512
E30.8 Other disorders of puberty
0.000 0.487 0.512
E30.1 Precocious puberty
0.000 0.487 0.512
E30.0 Delayed puberty
0.000 0.487 0.512
E31.9 Polyglandular dysfunction, unspecified
0.000 0.487 0.512
E31.8 Other polyglandular dysfunction
0.000 0.487 0.512
E31.1 Polyglandular hyperfunction
0.000 0.487 0.512
E31.0 Autoimmune polyglandular failure
0.000 0.487 0.512
E32.9 Disease of thymus, unspecified
0.000 0.487 0.512
E32.8 Other diseases of thymus
0.000 0.487 0.512
E32.1 Abscess of thymus
0.000 0.487 0.512
E32.0 Persistent hyperplasia of thymus
0.000 0.487 0.512
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.487 0.512
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.487 0.512
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.487 0.512
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.489 0.511
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.489 0.511
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.489 0.511
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.489 0.511
I02 Rheumatic chorea
0.000 0.489 0.511
I01 Rheumatic fever with heart involvement
0.000 0.489 0.511
I00 Rheumatic fever without mention of heart involvement
0.000 0.489 0.511
E20.8 Other hypoparathyroidism
0.000 0.502 0.498
E20.1 Pseudohypoparathyroidism
0.000 0.502 0.498
E20.0 Idiopathic hypoparathyroidism
0.000 0.502 0.498
E13 Other specified diabetes mellitus
0.000 0.502 0.497
E12.9 Without complications
0.000 0.506 0.494
E12.8 With unspecified complications
0.000 0.506 0.494
E12.7 With multiple complications
0.000 0.506 0.494
E12.6 With other specified complications
0.000 0.506 0.494
E12.5 With peripheral circulatory complications
0.000 0.506 0.494
E12.4 With neurological complications
0.000 0.506 0.494
E12.3 With ophthalmic complications
0.000 0.506 0.494
E12.2 With renal complications
0.000 0.506 0.494
E12.1 With ketoacidosis
0.000 0.506 0.494
E12.0 With coma
0.000 0.506 0.494
I20.0 Unstable angina
0.000 0.507 0.493
E06.5 Other chronic thyroiditis
0.000 0.511 0.489
I42.8 Other cardiomyopathies
0.000 0.517 0.483
I32.8 Pericarditis in other diseases classified elsewhere
0.000 0.519 0.481
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.519 0.481
I32.0 Pericarditis in bacterial diseases classified elsewhere
0.000 0.519 0.481
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere
0.000 0.519 0.481
I39.4 Multiple valve disorders in diseases classified elsewhere
0.000 0.519 0.481
I39.3 Pulmonary valve disorders in diseases classified elsewhere
0.000 0.519 0.481
I39.2 Tricuspid valve disorders in diseases classified elsewhere
0.000 0.519 0.481
I39.1 Aortic valve disorders in diseases classified elsewhere
0.000 0.519 0.481
I39.0 Mitral valve disorders in diseases classified elsewhere
0.000 0.519 0.481
I41.8 Myocarditis in other diseases classified elsewhere
0.000 0.519 0.481
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.519 0.481
I41.1 Myocarditis in viral diseases classified elsewhere
0.000 0.519 0.481
I41.0 Myocarditis in bacterial diseases classified elsewhere
0.000 0.519 0.481
I43.8 Cardiomyopathy in other diseases classified elsewhere
0.000 0.519 0.481
I43.2 Cardiomyopathy in nutritional diseases
0.000 0.519 0.481
I43.1 Cardiomyopathy in metabolic diseases
0.000 0.519 0.481
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere
0.000 0.519 0.481
I48.9 Atrial fibrillation and atrial flutter, unspecified
0.000 0.519 0.481
I48.4 Atypical atrial flutter
0.000 0.519 0.481
I48.3 Typical atrial flutter
0.000 0.519 0.481
I48.2 Chronic atrial fibrillation
0.000 0.519 0.481
I48.1 Persistent atrial fibrillation
0.000 0.519 0.481
I48.0 Paroxysmal atrial fibrillation
0.000 0.519 0.481
I52.8 Other heart disorders in other diseases classified elsewhere
0.000 0.519 0.481
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.519 0.481
I52.0 Other heart disorders in bacterial diseases classified elsewhere
0.000 0.519 0.481
I42.7 Cardiomyopathy due to drugs and other external agents
0.000 0.520 0.480
E20.9 Hypoparathyroidism, unspecified
0.000 0.523 0.477
I37.9 Pulmonary valve disorder, unspecified
0.000 0.524 0.476
I37.8 Other pulmonary valve disorders
0.000 0.524 0.476
I37.2 Pulmonary valve stenosis with insufficiency
0.000 0.524 0.476
I37.0 Pulmonary valve stenosis
0.000 0.524 0.476
E25.9 Adrenogenital disorder, unspecified
0.000 0.531 0.469
E25.8 Other adrenogenital disorders
0.000 0.531 0.469
I37.1 Pulmonary valve insufficiency
0.000 0.531 0.469
I50.0 Congestive heart failure
0.000 0.533 0.467
E14.3 With ophthalmic complications
0.000 0.534 0.466
I33.9 Acute endocarditis, unspecified
0.000 0.537 0.463
E07.1 Dyshormogenetic goitre
0.000 0.541 0.458
E07.0 Hypersecretion of calcitonin
0.000 0.541 0.458
E14.4 With neurological complications
0.000 0.543 0.457
E26.8 Other hyperaldosteronism
0.000 0.544 0.455
E26.1 Secondary hyperaldosteronism
0.000 0.544 0.455
E50.9 Vitamin A deficiency, unspecified
0.000 0.546 0.453
E50.8 Other manifestations of vitamin A deficiency
0.000 0.546 0.453
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.546 0.453
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.546 0.453
E50.5 Vitamin A deficiency with night blindness
0.000 0.546 0.453
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.546 0.453
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.546 0.453
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.546 0.453
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.546 0.453
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.546 0.453
E51.9 Thiamine deficiency, unspecified
0.000 0.546 0.453
E51.8 Other manifestations of thiamine deficiency
0.000 0.546 0.453
E51.2 Wernicke's encephalopathy
0.000 0.546 0.453
E51.1 Beriberi
0.000 0.546 0.453
E56.9 Vitamin deficiency, unspecified
0.000 0.546 0.453
E56.8 Deficiency of other vitamins
0.000 0.546 0.453
E56.1 Deficiency of vitamin K
0.000 0.546 0.453
E56.0 Deficiency of vitamin E
0.000 0.546 0.453
E63.9 Nutritional deficiency, unspecified
0.000 0.546 0.453
E63.8 Other specified nutritional deficiencies
0.000 0.546 0.453
E63.1 Imbalance of constituents of food intake
0.000 0.546 0.453
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.546 0.453
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.546 0.453
E64.8 Sequelae of other nutritional deficiencies
0.000 0.546 0.453
E64.3 Sequelae of rickets
0.000 0.546 0.453
E64.2 Sequelae of vitamin C deficiency
0.000 0.546 0.453
E64.1 Sequelae of vitamin A deficiency
0.000 0.546 0.453
E64.0 Sequelae of protein-energy malnutrition
0.000 0.546 0.453
I30 Acute pericarditis
0.001 0.550 0.449
I49.1 Atrial premature depolarisation
0.000 0.553 0.447
E14.6 With other specified complications
0.000 0.555 0.445
E14.1 With ketoacidosis
0.000 0.558 0.442
E07.8 Other specified disorders of thyroid
0.000 0.562 0.438
I33.0 Acute and subacute infective endocarditis
0.000 0.563 0.437
E16.1 Other hypoglycaemia
0.000 0.565 0.435
E55.0 Rickets, active
0.000 0.566 0.434
E22.0 Acromegaly and pituitary gigantism
0.000 0.569 0.431
E26.9 Hyperaldosteronism, unspecified
0.000 0.570 0.429
E14.7 With multiple complications
0.000 0.577 0.423
E14.2 Withrenal complications
0.000 0.577 0.423
E14.0 With coma
0.000 0.577 0.423
E14.5 With peripheral circulatory complications
0.000 0.578 0.422
I36.9 Nonrheumatic tricuspid valve disorder, unspecified
0.000 0.584 0.416
I36.8 Other nonrheumatic tricuspid valve disorders
0.000 0.584 0.416
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency
0.000 0.584 0.416
I36.0 Nonrheumatic tricuspid (valve) stenosis
0.000 0.584 0.416
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.590 0.409
E26.0 Primary hyperaldosteronism
0.000 0.591 0.409
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.591 0.409
E07.9 Disorder of thyroid, unspecified
0.000 0.592 0.408
E55.9 Vitamin D deficiency, unspecified
0.000 0.593 0.407
I05-I09 Chronic rheumatic heart diseases
0.000 0.594 0.406
E16.2 Hypoglycaemia, unspecified
0.000 0.594 0.406
I15.8 Other secondary hypertension
0.000 0.595 0.405
I15.2 Hypertension secondary to endocrine disorders
0.000 0.595 0.405
I15.0 Renovascular hypertension
0.000 0.595 0.405
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.598 0.402
E24.0 Pituitary-dependent Cushing's disease
0.000 0.608 0.391
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.610 0.390
E45 Retarded development following protein-energy malnutrition
0.000 0.610 0.390
E43 Unspecified severe protein-energy malnutrition
0.000 0.610 0.390
E42 Marasmic kwashiorkor
0.000 0.610 0.390
E41 Nutritional marasmus
0.000 0.610 0.390
E40 Kwashiorkor
0.000 0.610 0.390
I35.1 Aortic (valve) insufficiency
0.000 0.611 0.389
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.612 0.388
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.612 0.388
E16.4 Abnormal secretion of gastrin
0.000 0.612 0.388
E16.3 Increased secretion of glucagon
0.000 0.612 0.388
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.613 0.387
E24.3 Ectopic ACTH syndrome
0.000 0.613 0.387
E24.1 Nelson's syndrome
0.000 0.613 0.387
E29.9 Testicular dysfunction, unspecified
0.000 0.617 0.382
E29.8 Other testicular dysfunction
0.000 0.617 0.382
E29.0 Testicular hyperfunction
0.000 0.617 0.382
I38 Endocarditis, valve unspecified
0.000 0.621 0.379
I40.8 Other acute myocarditis
0.000 0.623 0.376
I40.1 Isolated myocarditis
0.000 0.623 0.376
I20.1 Angina pectoris with documented spasm
0.000 0.627 0.372
E65-E68 Obesity and other hyperalimentation
0.000 0.630 0.370
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.633 0.366
I01.8 Other acute rheumatic heart disease
0.000 0.633 0.366
I01.2 Acute rheumatic myocarditis
0.000 0.633 0.366
I01.1 Acute rheumatic endocarditis
0.000 0.633 0.366
I01.0 Acute rheumatic pericarditis
0.000 0.633 0.366
I02.9 Rheumatic chorea without heart involvement
0.000 0.633 0.366
I02.0 Rheumatic chorea with heart involvement
0.000 0.633 0.366
E13.8 With unspecified complications
0.000 0.643 0.357
E13.7 With multiple complications
0.000 0.643 0.357
E13.6 With other specified complications
0.000 0.643 0.357
E13.5 With peripheral circulatory complications
0.000 0.643 0.357
E13.4 With neurological complications
0.000 0.643 0.357
E13.2 With renal complications
0.000 0.643 0.357
E13.1 With ketoacidosis
0.000 0.643 0.357
E13.0 With coma
0.000 0.643 0.357
I40.9 Acute myocarditis, unspecified
0.001 0.643 0.356
E24.2 Drug-induced Cushing's syndrome
0.000 0.645 0.355
E24.8 Other Cushing's syndrome
0.000 0.653 0.347
I15.1 Hypertension secondary to other renal disorders
0.000 0.653 0.347
I12 Hypertensive renal disease
0.000 0.660 0.340
I15.9 Seconday hypertension, unspecified
0.000 0.662 0.338
I31 Other diseases of pericardium
0.000 0.666 0.334
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.000 0.675 0.324
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.676 0.324
I45 Other conduction disorders
0.000 0.677 0.323
E13.3 With ophthalmic complications
0.000 0.677 0.323
I30.8 Other forms of acute pericarditis
0.001 0.677 0.322
I30.0 Acute nonspecific idiopathic pericarditis
0.001 0.677 0.322
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.683 0.317
E24.9 Cushing's syndrome, unspecified
0.000 0.683 0.316
I30.1 Infective pericarditis
0.001 0.683 0.316
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.688 0.312
E14.8 With unspecified complications
0.000 0.692 0.307
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.000 0.705 0.295
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.001 0.714 0.285
I06 Rheumatic aortic valve diseases
0.000 0.719 0.280
E44.1 Mild protein-energy malnutrition
0.000 0.720 0.280
E44.0 Moderate protein-energy malnutrition
0.000 0.720 0.280
I07 Rheumatic tricuspid valve diseases
0.000 0.721 0.279
I78 Diseases of capillaries
0.000 0.722 0.278
I46 Cardiac arrest
0.000 0.723 0.277
E67 Other hyperalimentation
0.000 0.734 0.266
E68 Sequelae of hyperalimentation
0.000 0.734 0.266
I40.0 Infective myocarditis
0.001 0.735 0.264
I05 Rheumatic mitral valve diseases
0.000 0.737 0.263
I73 Other peripheral vascular diseases
0.000 0.739 0.261
I80 Phlebitis and thrombophlebitis
0.000 0.743 0.257
I45.6 Preexcitation syndrome
0.000 0.747 0.253
I45.4 Nonspecific intraventricular block
0.000 0.748 0.252
I31.1 Chronic constrictive pericarditis
0.000 0.749 0.251
I09 Other rheumatic heart diseases
0.000 0.749 0.250
I45.9 Conduction disorder, unspecified
0.000 0.752 0.248
I31.0 Chronic adhesive pericarditis
0.000 0.753 0.247
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.754 0.246
I73.0 Raynaud's syndrome
0.000 0.759 0.241
I85 Oesophageal varices
0.000 0.759 0.241
I45.8 Other specified conduction disorders
0.000 0.759 0.241
E14.9 Without complications
0.000 0.760 0.240
I31.8 Other specified diseases of pericardium
0.000 0.760 0.239
I31.2 Haemopericardium, not elsewhere classified
0.000 0.760 0.239
I45.0 Right fascicular block
0.000 0.768 0.232
I86 Varicose veins of other sites
0.000 0.769 0.231
I80.1 Phlebitis and thrombophlebitis of femoral vein
0.000 0.770 0.230
E13.9 Without complications
0.000 0.770 0.229
I95 Hypotension
0.000 0.773 0.227
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.773 0.227
I80.9 Phlebitis and thrombophlebitis of unspecified site
0.000 0.774 0.226
I78.8 Other diseases of capillaries
0.000 0.775 0.224
I82 Other venous embolism and thrombosis
0.000 0.778 0.222
E46 Unspecified protein-energy malnutrition
0.001 0.781 0.219
I86.4 Gastric varices
0.000 0.781 0.219
I85.0 Oesophageal varices with bleeding
0.000 0.784 0.216
E65 Localised adiposity
0.000 0.784 0.215
I05.0 Mitral stenosis
0.000 0.795 0.205
I45.5 Other specified heart block
0.000 0.798 0.202
I80.3 Phlebitis and thrombophlebitis of lower extremities, unspecified
0.000 0.798 0.202
I45.2 Bifascicular block
0.000 0.798 0.202
I06.9 Rheumatic aortic valve disease, unspecified
0.000 0.799 0.201
I06.8 Other rheumatic aortic valve diseases
0.000 0.799 0.201
I06.2 Rheumatic aortic stenosis with insufficiency
0.000 0.799 0.201
I06.0 Rheumatic aortic stenosis
0.000 0.799 0.201
E29.1 Testicular hypofunction
0.001 0.799 0.201
I07.9 Tricuspid valve disease, unspecified
0.000 0.800 0.200
I07.8 Other tricuspid valve diseases
0.000 0.800 0.200
I07.2 Tricuspid stenosis with insufficiency
0.000 0.800 0.200
I07.0 Tricuspid stenosis
0.000 0.800 0.200
I05.2 Mitral stenosis with insufficiency
0.000 0.800 0.200
I08 Multiple valve diseases
0.000 0.800 0.200
I78.9 Disease of capillaries, unspecified
0.000 0.800 0.200
I46.1 Sudden cardiac death, so described
0.000 0.801 0.199
I44 Atrioventricular and left bundle-branch block
0.000 0.803 0.197
I72 Other aneurysm
0.000 0.804 0.196

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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