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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs74357743
log Bayes Factor = 13.6586
Chromosome 8   position 74,712,506  (GRCh37) Explore rs74357743 on Ensembl!
Variant rs74357743 is part of Cluster X0021

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
0.999 0.001 0.000
M50-M54 Other dorsopathies
0.996 0.004 0.000
Chapter XX External causes of morbidity and mortality
0.996 0.004 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.994 0.006 0.000
M54 Dorsalgia
0.992 0.008 0.000
M70-M79 Other soft tissue disorders
0.991 0.009 0.000
M45-M49 Spondylopathies
0.989 0.011 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.986 0.014 0.000
I30-I52 Other forms of heart disease
0.975 0.025 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.974 0.026 0.000
T81 Complications of procedures, not elsewhere classified
0.973 0.027 0.000
T81.4 Infection following a procedure, not elsewhere classified
0.961 0.039 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.960 0.040 0.000
M54.5 Low back pain
0.958 0.042 0.000
M47 Spondylosis
0.957 0.043 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.956 0.044 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.955 0.045 0.000
I60-I69 Cerebrovascular diseases
0.946 0.054 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.946 0.054 0.000
M15-M19 Arthrosis
0.945 0.055 0.000
I49 Other cardiac arrhythmias
0.939 0.061 0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts
0.925 0.075 0.000
M19 Other arthrosis
0.924 0.076 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.915 0.085 0.000
M79.8 Other specified soft tissue disorders
0.910 0.090 0.000
M54.9 Dorsalgia, unspecified
0.909 0.091 0.000
M19.9 Arthrosis, unspecified
0.909 0.091 0.000
M48 Other spondylopathies
0.907 0.093 0.000
M20-M25 Other joint disorders
0.906 0.094 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.905 0.095 0.000
W20-W49 Exposure to inanimate mechanical forces
0.903 0.097 0.000
I51 Complications and ill-defined descriptions of heart disease
0.901 0.099 0.000
Chapter I Certain infectious and parasitic diseases
0.897 0.103 0.000
M19.97 Arthrosis, unspecified (Ankle and foot)
0.892 0.108 0.000
Chapter XXI Factors influencing health status and contact with health services
0.891 0.109 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.890 0.110 0.000
I83 Varicose veins of lower extremities
0.890 0.110 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.889 0.111 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.885 0.115 0.000
I74 Arterial embolism and thrombosis
0.882 0.118 0.000
M05-M14 Inflammatory polyarthropathies
0.881 0.119 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.881 0.119 0.000
T83.0 Mechanical complication of urinary (indwelling) catheter
0.878 0.122 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.878 0.122 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.876 0.124 0.000
M79.6 Pain in limb
0.874 0.126 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.873 0.127 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.870 0.130 0.000
M47.2 Other spondylosis with radiculopathy
0.870 0.130 0.000
I80 Phlebitis and thrombophlebitis
0.870 0.130 0.000
Chapter VIII Diseases of the ear and mastoid process
0.866 0.134 0.000
M47.9 Spondylosis, unspecified
0.866 0.134 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.864 0.136 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.862 0.138 0.000
M54.56 Low back pain (Lumbar region)
0.855 0.145 0.000
M79.9 Soft tissue disorder, unspecified
0.854 0.145 0.000
Z96 Presence of other functional implants
0.851 0.149 0.000
M54.99 Dorsalgia, unspecified (Site unspecified)
0.849 0.151 0.000
I51.8 Other ill-defined heart diseases
0.848 0.152 0.000
M48.0 Spinal stenosis
0.848 0.152 0.000
M23 Internal derangement of knee
0.844 0.156 0.000
S60-S69 Injuries to the wrist and hand
0.843 0.157 0.000
Chapter XXII Codes for special purposes
0.843 0.157 0.000
T83.1 Mechanical complication of other urinary devices and implants
0.839 0.161 0.000
I49.8 Other specified cardiac arrhythmias
0.839 0.161 0.000
B95-B98 Bacterial, viral and other infectious agents
0.839 0.161 0.000
I71 Aortic aneurysm and dissection
0.837 0.163 0.000
M79.5 Residual foreign body in soft tissue
0.835 0.164 0.000
I05-I09 Chronic rheumatic heart diseases
0.834 0.166 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.834 0.166 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.830 0.170 0.000
I83.1 Varicose veins of lower extremities with inflammation
0.829 0.171 0.000
M54.57 Low back pain (Lumbosacral region)
0.827 0.173 0.000
S40-S49 Injuries to the shoulder and upper arm
0.826 0.174 0.000
I49.9 Cardiac arrhythmia, unspecified
0.825 0.175 0.000
M25 Other joint disorders, not elsewhere classified
0.825 0.175 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.824 0.176 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.822 0.178 0.000
M54.3 Sciatica
0.821 0.179 0.000
M77 Other enthesopathies
0.815 0.185 0.000
I63 Cerebral infarction
0.814 0.186 0.000
I34 Nonrheumatic mitral valve disorders
0.810 0.190 0.000
Z96.0 Presence of urogenital implants
0.809 0.191 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.808 0.192 0.000
M79.7 Fibromyalgia
0.807 0.193 0.000
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities
0.806 0.194 0.000
Z86 Personal history of certain other diseases
0.805 0.195 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.804 0.196 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.803 0.197 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.803 0.197 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.800 0.200 0.000
M50 Cervical disk disorders
0.797 0.203 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.797 0.203 0.000
Z86.7 Personal history of diseases of the circulatory system
0.797 0.203 0.000
V10-V19 Pedal cyclist injured in transport accident
0.797 0.203 0.000
M54.2 Cervicalgia
0.794 0.206 0.000
M79.89 Other specified soft tissue disorders (Site unspecified)
0.793 0.207 0.000
Z82 Family history of certain disabilities and chronic diseases leading to disablement
0.792 0.208 0.000
M79.1 Myalgia
0.791 0.209 0.000
M54.1 Radiculopathy
0.790 0.210 0.000
M19.93 Arthrosis, unspecified (Forearm)
0.790 0.210 0.000
M23.3 Other meniscus derangements
0.790 0.210 0.000
Z93 Artificial opening status
0.790 0.210 0.000
S90-S99 Injuries to the ankle and foot
0.787 0.213 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.785 0.215 0.000
M19.94 Arthrosis, unspecified (Hand)
0.784 0.216 0.000
L08 Other local infections of skin and subcutaneous tissue
0.784 0.216 0.000
O60-O75 Complications of labour and delivery
0.783 0.217 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.781 0.219 0.000
Z40-Z54 Persons encountering health services for specific procedures and health care
0.781 0.219 0.000
M54.59 Low back pain (Site unspecified)
0.781 0.219 0.000
S70-S79 Injuries to the hip and thigh
0.780 0.219 0.000
Y95 Nosocomial condition
0.780 0.220 0.000
T66-T78 Other and unspecified effects of external causes
0.778 0.222 0.000
O26 Maternal care for other conditions predominantly related to pregnancy
0.777 0.223 0.000
E65-E68 Obesity and other hyperalimentation
0.776 0.223 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.776 0.224 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.775 0.225 0.000
M47.99 Spondylosis, unspecified (Site unspecified)
0.774 0.226 0.000
S50-S59 Injuries to the elbow and forearm
0.773 0.227 0.000
M45 Ankylosing spondylitis
0.772 0.228 0.000
I46 Cardiac arrest
0.768 0.232 0.000
Z98 Other postsurgical states
0.766 0.234 0.000
M79.86 Other specified soft tissue disorders (Lower leg)
0.766 0.234 0.000
T86 Failure and rejection of transplanted organs and tissues
0.764 0.236 0.000
I72 Other aneurysm
0.761 0.239 0.000
I49.3 Ventricular premature depolarisation
0.761 0.239 0.000
M54.4 Lumbago with sciatica
0.761 0.239 0.000
M79.96 Soft tissue disorder, unspecified (Lower leg)
0.760 0.240 0.000
Z96.1 Presence of intraocular lens
0.760 0.240 0.000
S10-S19 Injuries to the neck
0.760 0.240 0.000
L03 Cellulitis
0.759 0.241 0.000
M48.02 Spinal stenosis (Cervical region)
0.759 0.241 0.000
I61 Intracerebral haemorrhage
0.758 0.242 0.000
S20-S29 Injuries to the thorax
0.756 0.244 0.000
E20-E35 Disorders of other endocrine glands
0.755 0.245 0.000
A30-A49 Other bacterial diseases
0.755 0.245 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.754 0.246 0.000
M19.95 Arthrosis, unspecified (Pelvic region and thigh)
0.754 0.246 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.754 0.246 0.000
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified
0.753 0.247 0.000
M54.58 Low back pain (Sacral and sacrococcygeal region)
0.751 0.249 0.000
T81.2 Accidental puncture and laceration during a procedure, not elsewhere classified
0.751 0.249 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.751 0.249 0.000
S61 Open wound of wrist and hand
0.751 0.249 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.750 0.250 0.000
T81.5 Foreign body accidentally left in body cavity or operation wound following a procedure
0.750 0.250 0.000
I78 Diseases of capillaries
0.750 0.250 0.000
I31 Other diseases of pericardium
0.747 0.253 0.000
W22 Striking against or struck by other objects
0.746 0.254 0.000
I50 Heart failure
0.745 0.255 0.000
M05 Seropositive rheumatoid arthritis
0.745 0.255 0.000
M72 Fibroblastic disorders
0.744 0.256 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.742 0.258 0.000
Y83.3 Surgical operation with formation of external stoma
0.742 0.258 0.000
I69 Sequelae of cerebrovascular disease
0.742 0.258 0.000
Z47 Other orthopaedic follow-up care
0.742 0.258 0.000
O80-O84 Delivery
0.740 0.260 0.000
Q80-Q89 Other congenital malformations
0.739 0.261 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.738 0.262 0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.737 0.263 0.000
Z82.3 Family history of stroke
0.737 0.263 0.000
Y43 Primarily systemic agents
0.735 0.265 0.000
M13 Other arthritis
0.735 0.265 0.000
V80-V89 Other land transport accidents
0.733 0.267 0.000
I49.0 Ventricular fibrillation and flutter
0.733 0.267 0.000
B96.2 Escherichia coli [E. coli] as the cause of diseases classified to other chapters
0.733 0.267 0.000
H90-H95 Other disorders of ear
0.732 0.268 0.000
L08.9 Local infection of skin and subcutaneous tissue, unspecified
0.730 0.270 0.000
Y83.6 Removal of other organ (partial) (total)
0.730 0.270 0.000
M86-M90 Other osteopathies
0.729 0.271 0.000
I74.5 Embolism and thrombosis of iliac artery
0.729 0.271 0.000
M79.54 Residual foreign body in soft tissue (Hand)
0.728 0.272 0.000
W44 Foreign body entering into or through eye or natural orifice
0.728 0.272 0.000
E10-E14 Diabetes mellitus
0.727 0.273 0.000
M25.4 Effusion of joint
0.724 0.276 0.000
W00-W19 Falls
0.723 0.277 0.000
H80-H83 Diseases of inner ear
0.722 0.277 0.000
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.722 0.278 0.000
I08 Multiple valve diseases
0.722 0.278 0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.721 0.279 0.000
M47.1 Other spondylosis with myelopathy
0.720 0.280 0.000
M91-M94 Chondropathies
0.719 0.281 0.000
I63.9 Cerebral infarction, unspecified
0.719 0.281 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.719 0.281 0.000
O26.8 Other specified pregnancy-related conditions
0.718 0.282 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.718 0.282 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T87 Complications peculiar to reattachment and amputation
0.717 0.283 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
M47.22 Other spondylosis with radiculopathy (Cervical region)
0.717 0.283 0.000
M47.8 Other spondylosis
0.716 0.284 0.000
M53 Other dorsopathies, not elsewhere classified
0.716 0.284 0.000
M47.26 Other spondylosis with radiculopathy (Lumbar region)
0.716 0.284 0.000
M48.09 Spinal stenosis (Site unspecified)
0.715 0.284 0.000
M71 Other bursopathies
0.715 0.285 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.715 0.285 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.714 0.286 0.000
Y35-Y36 Legal intervention and operations of war
0.714 0.286 0.000
Y10-Y34 Event of undetermined intent
0.714 0.286 0.000
Y00-Y09 Assault
0.714 0.286 0.000
X85-X99 Assault
0.714 0.286 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.714 0.286 0.000
X50-X57 Overexertion, travel and privation
0.714 0.286 0.000
X30-X39 Exposure to forces of nature
0.714 0.286 0.000
X20-X29 Contact with venomous animals and plants
0.714 0.286 0.000
X10-X19 Contact with heat and hot substances
0.714 0.286 0.000
X00-X09 Exposure to smoke, fire and flames
0.714 0.286 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.714 0.286 0.000
W75-W84 Other accidental threats to breathing
0.714 0.286 0.000
W65-W74 Accidental drowning and submersion
0.714 0.286 0.000
W50-W64 Exposure to animate mechanical forces
0.714 0.286 0.000
V98-V99 Other and unspecified transport accidents
0.714 0.286 0.000
V95-V97 Air and space transport accidents
0.714 0.286 0.000
V90-V94 Water transport accidents
0.714 0.286 0.000
V70-V79 Bus occupant injured in transport accident
0.714 0.286 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.714 0.286 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.714 0.286 0.000
V40-V49 Car occupant injured in transport accident
0.714 0.286 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.714 0.286 0.000
V01-V09 Pedestrian injured in transport accident
0.714 0.286 0.000
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities
0.714 0.286 0.000
X60-X84 Intentional self-harm
0.713 0.287 0.000
T79-T79 Certain early complications of trauma
0.713 0.287 0.000
I47 Paroxysmal tachycardia
0.713 0.287 0.000
M40-M43 Deforming dorsopathies
0.713 0.287 0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft
0.712 0.288 0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts
0.712 0.288 0.000
T84.3 Mechanical complication of other bone devices, implants and grafts
0.712 0.288 0.000
M79.64 Pain in limb (Hand)
0.712 0.288 0.000
D68 Other coagulation defects
0.712 0.288 0.000
M54.8 Other dorsalgia
0.711 0.288 0.000
M54.6 Pain in thoracic spine
0.711 0.288 0.000
M54.0 Panniculitis affecting regions of neck and back
0.711 0.288 0.000
M76 Enthesopathies of lower limb, excluding foot
0.710 0.290 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.710 0.290 0.000
Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device
0.710 0.290 0.000
M49 Spondylopathies in diseases classified elsewhere
0.709 0.291 0.000
M47.27 Other spondylosis with radiculopathy (Lumbosacral region)
0.709 0.291 0.000
M19.92 Arthrosis, unspecified (Upper arm)
0.709 0.291 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.708 0.291 0.000
I20-I25 Ischaemic heart diseases
0.709 0.291 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.708 0.292 0.000
Z96.6 Presence of orthopaedic joint implants
0.708 0.292 0.000
E66 Obesity
0.708 0.292 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.707 0.293 0.000
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)
0.707 0.293 0.000
M79.0 Rheumatism, unspecified
0.707 0.293 0.000
M79.4 Hypertrophy of (infrapatellar) fat pad
0.707 0.293 0.000
M79.3 Panniculitis, unspecified
0.707 0.293 0.000
M79.2 Neuralgia and neuritis, unspecified
0.707 0.293 0.000
M79.80 Other specified soft tissue disorders (Multiple sites)
0.706 0.294 0.000
M79.65 Pain in limb (Pelvic region and thigh)
0.706 0.294 0.000
W29 Contact with other powered hand tools and household machinery
0.705 0.295 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.704 0.295 0.000
S80-S89 Injuries to the knee and lower leg
0.704 0.296 0.000
I70 Atherosclerosis
0.704 0.296 0.000
I30 Acute pericarditis
0.703 0.297 0.000
W21 Striking against or struck by sports equipment
0.701 0.299 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.701 0.299 0.000
M16 Coxarthrosis [arthrosis of hip]
0.701 0.299 0.000
I45 Other conduction disorders
0.701 0.299 0.000
M79.69 Pain in limb (Site unspecified)
0.701 0.299 0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.700 0.300 0.000
M46 Other inflammatory spondylopathies
0.699 0.300 0.000
I52 Other heart disorders in diseases classified elsewhere
0.699 0.301 0.000
I48 Atrial fibrillation and flutter
0.699 0.301 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.699 0.301 0.000
I41 Myocarditis in diseases classified elsewhere
0.699 0.301 0.000
I40 Acute myocarditis
0.699 0.301 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.699 0.301 0.000
I37 Pulmonary valve disorders
0.699 0.301 0.000
I36 Nonrheumatic tricuspid valve disorders
0.699 0.301 0.000
I33 Acute and subacute endocarditis
0.699 0.301 0.000
I32 Pericarditis in diseases classified elsewhere
0.699 0.301 0.000
I80.8 Phlebitis and thrombophlebitis of other sites
0.698 0.302 0.000
M54.39 Sciatica (Site unspecified)
0.698 0.302 0.000
T81.9 Unspecified complication of procedure
0.697 0.302 0.000
T81.7 Vascular complications following a procedure, not elsewhere classified
0.697 0.302 0.000
T81.6 Acute reaction to foreign substance accidentally left during a procedure
0.697 0.302 0.000
T81.1 Shock during or resulting from a procedure, not elsewhere classified
0.697 0.302 0.000
Chapter X Diseases of the respiratory system
0.696 0.304 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.695 0.304 0.000
M22 Disorders of patella
0.695 0.305 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.694 0.306 0.000
T83.8 Other complications of genito-urinary prosthetic devices, implants and grafts
0.693 0.306 0.000
M48.00 Spinal stenosis (Multiple sites in spine)
0.692 0.308 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.691 0.309 0.000
Z98.0 Intestinal bypass and anastomosis status
0.691 0.309 0.000
T83.3 Mechanical complication of intra-uterine contraceptive device
0.690 0.310 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.688 0.312 0.000
L03.2 Cellulitis of face
0.688 0.312 0.000
T82.1 Mechanical complication of cardiac electronic device
0.687 0.312 0.000
M21 Other acquired deformities of limbs
0.687 0.313 0.000
M54.55 Low back pain (Thoracolumbar region)
0.687 0.313 0.000
M54.54 Low back pain-Thoracic
0.687 0.313 0.000
M54.53 Low back pain-Cervicothoracic
0.687 0.313 0.000
M54.52 Low back pain-Cervical
0.687 0.313 0.000
M54.51 Low back pain-Occipit-atl-axl
0.687 0.313 0.000
M54.50 Low back pain (Multiple sites in spine)
0.687 0.313 0.000
M47.0 Anterior spinal and vertebral artery compression syndromes
0.686 0.314 0.000
Y52 Agents primarily affecting the cardiovascular system
0.685 0.315 0.000
T83.9 Unspecified complication of genito-urinary prosthetic device, implant and graft
0.685 0.315 0.000
T83.6 Infection and inflammatory reaction due to prosthetic device, implant and graft in genital tract
0.685 0.315 0.000
T83.5 Infection and inflammatory reaction due to prosthetic device, implant and graft in urinary system
0.685 0.315 0.000
T83.4 Mechanical complication of other prosthetic devices, implants and grafts in genital tract
0.685 0.315 0.000
T83.2 Mechanical complication of graft of urinary organ
0.685 0.315 0.000
O85-O92 Complications predominantly related to the puerperium
0.685 0.315 0.000
Z48 Other surgical follow-up care
0.684 0.316 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.682 0.317 0.000
Z96.8 Presence of other specified functional implants
0.682 0.318 0.000
V20-V29 Motorcycle rider injured in transport accident
0.682 0.318 0.000
S61.9 Open wound of wrist and hand, part unspecified
0.682 0.318 0.000
M79.60 Pain in limb (Multiple sites)
0.681 0.318 0.000
I50.9 Heart failure, unspecified
0.681 0.319 0.000
M51 Other intervertebral disk disorders
0.681 0.319 0.000
M25.8 Other specified joint disorders
0.680 0.319 0.000
O24 Diabetes mellitus in pregnancy
0.680 0.320 0.000
M79.62 Pain in limb (Upper arm)
0.680 0.320 0.000
M79.79 Fibromyalgia (Site unspecified)
0.679 0.321 0.000
Q00-Q07 Congenital malformations of the nervous system
0.679 0.321 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.678 0.322 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.678 0.322 0.000
L20-L30 Dermatitis and eczema
0.678 0.322 0.000
I88 Nonspecific lymphadenitis
0.678 0.322 0.000
I82 Other venous embolism and thrombosis
0.678 0.322 0.000
I81 Portal vein thrombosis
0.678 0.322 0.000
I73 Other peripheral vascular diseases
0.678 0.322 0.000
M15 Polyarthrosis
0.677 0.323 0.000
M19.1 Posttraumatic arthrosis of other joints
0.675 0.325 0.000
I87 Other disorders of veins
0.675 0.325 0.000
D60-D64 Aplastic and other anaemias
0.674 0.326 0.000
M19.0 Primary arthrosis of other joints
0.673 0.327 0.000
M80-M85 Disorders of bone density and structure
0.673 0.327 0.000
I49.2 Junctional premature depolarisation
0.673 0.327 0.000
I49.1 Atrial premature depolarisation
0.673 0.327 0.000
O23 Infections of genito-urinary tract in pregnancy
0.673 0.327 0.000
M77.5 Other enthesopathy of foot
0.673 0.327 0.000
I51.9 Heart disease, unspecified
0.672 0.328 0.000
I86 Varicose veins of other sites
0.671 0.329 0.000
M65-M68 Disorders of synovium and tendon
0.670 0.330 0.000
O43 Placental disorders
0.670 0.330 0.000
I60 Subarachnoid haemorrhage
0.670 0.330 0.000
Z82.7 Family history of congenital malformations, deformations and chromosomal abnormalities
0.669 0.331 0.000
H60-H62 Diseases of external ear
0.669 0.331 0.000
Z93.4 Other artificial openings of gastro-intestinal tract status
0.669 0.331 0.000
O35 Maternal care for known or suspected foetal abnormality and damage
0.669 0.331 0.000
B96.4 Proteus (mirabilis)(morganii) as the cause of diseases classified to other chapters
0.668 0.331 0.000
M10 Gout
0.667 0.333 0.000
Y40 Systemic antibiotics
0.666 0.334 0.000
Q21 Congenital malformations of cardiac septa
0.665 0.335 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.663 0.337 0.000
Z40 Prophylactic surgery
0.663 0.337 0.000
M19.8 Other specified arthrosis
0.663 0.337 0.000
M19.2 Other secondary arthrosis
0.663 0.337 0.000
D70 Agranulocytosis
0.663 0.337 0.000
M47.96 Spondylosis, unspecified (Lumbar region)
0.662 0.338 0.000
I49.4 Other and unspecified premature depolarisation
0.662 0.338 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.661 0.338 0.000
T85.4 Mechanical complication of breast prosthesis and implant
0.661 0.339 0.000
Z83 Family history of other specific disorders
0.660 0.340 0.000
D75 Other diseases of blood and blood-forming organs
0.660 0.340 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.658 0.342 0.000
M48.07 Spinal stenosis (Lumbosacral region)
0.658 0.342 0.000
M31 Other necrotising vasculopathies
0.657 0.343 0.000
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)
0.657 0.343 0.000
M77.9 Enthesopathy, unspecified
0.657 0.343 0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.656 0.343 0.000
M50.2 Other cervical disk displacement
0.656 0.344 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.656 0.344 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.656 0.344 0.000
Q50-Q56 Congenital malformations of genital organs
0.656 0.344 0.000
Q35-Q37 Cleft lip and cleft palate
0.656 0.344 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.656 0.344 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.656 0.344 0.000
O20 Haemorrhage in early pregnancy
0.656 0.344 0.000
I34.0 Mitral (valve) insufficiency
0.656 0.344 0.000
M07 Psoriatic and enteropathic arthropathies
0.655 0.345 0.000
V18 Pedal cyclist injured in noncollision transport accident
0.654 0.346 0.000
M54.96 Dorsalgia, unspecified (Lumbar region)
0.654 0.346 0.000
J95-J99 Other diseases of the respiratory system
0.654 0.346 0.000
M79.88 Other specified soft tissue disorders (Other)
0.653 0.347 0.000
M79.85 Other specified soft tissue disorders (Pelvic region and thigh)
0.653 0.347 0.000
M79.84 Other specified soft tissue disorders (Hand)
0.653 0.347 0.000
M79.83 Other specified soft tissue disorders (Forearm)
0.653 0.347 0.000
M79.82 Other specified soft tissue disorders (Upper arm)
0.653 0.347 0.000
M79.81 Other specified soft tissue disorders (Shoulder region)
0.653 0.347 0.000
M54.98 Dorsalgia, unspecified (Sacral and sacrococcygeal region)
0.652 0.348 0.000
M54.97 Dorsalgia, unspecified (Lumbosacral region)
0.652 0.348 0.000
M54.95 Dorsalgia, unspecified (Thoracolumbar region)
0.652 0.348 0.000
M54.94 Dorsalgia, unspecified (Thoracic region)
0.652 0.348 0.000
M54.93 Dorsalgia, unspecified (Cervicothoracic region)
0.652 0.348 0.000
M54.92 Dorsalgia, unspecified (Cervical region)
0.652 0.348 0.000
M54.91 Dorsalgia, unspecified (Occipito-atlanto-axial region)
0.652 0.348 0.000
M54.90 Dorsalgia, unspecified (Multiple sites in spine)
0.652 0.348 0.000
M54.22 Cervicalgia (Cervical region)
0.651 0.349 0.000
M79.10 Myalgia (Multiple sites)
0.651 0.349 0.000
T85.5 Mechanical complication of gastro-intestinal prosthetic devices, implants and grafts
0.651 0.349 0.000
M47.92 Spondylosis, unspecified (Cervical region)
0.651 0.349 0.000
M48.9 Spondylopathy, unspecified
0.650 0.350 0.000
M48.8 Other specified spondylopathies
0.650 0.350 0.000
M48.5 Collapsed vertebra, not elsewhere classified
0.650 0.350 0.000
M48.4 Fatigue fracture of vertebra
0.650 0.350 0.000
M48.3 Traumatic spondylopathy
0.650 0.350 0.000
M48.2 Kissing spine
0.650 0.350 0.000
M48.1 Ankylosing hyperostosis [Forestier]
0.650 0.350 0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]
0.650 0.350 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.649 0.350 0.000
M34 Systemic sclerosis
0.649 0.350 0.000
M33 Dermatopolymyositis
0.649 0.350 0.000
M32 Systemic lupus erythematosus
0.649 0.350 0.000
M30 Polyarteritis nodosa and related conditions
0.649 0.350 0.000
Z93.1 Gastrostomy status
0.649 0.350 0.000
D55-D59 Haemolytic anaemias
0.649 0.351 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.649 0.351 0.000
S40 Superficial injury of shoulder and upper arm
0.648 0.352 0.000
W49 Exposure to other and unspecified inanimate mechanical forces
0.648 0.352 0.000
W46 Contact with hypodermic needle
0.648 0.352 0.000
W45 Foreign body or object entering through skin
0.648 0.352 0.000
W43 Exposure to vibration
0.648 0.352 0.000
W42 Exposure to noise
0.648 0.352 0.000
W41 Exposure to high-pressure jet
0.648 0.352 0.000
W40 Explosion of other materials
0.648 0.352 0.000
W39 Discharge of firework
0.648 0.352 0.000
W38 Explosion and rupture of other specified pressurised devices
0.648 0.352 0.000
W37 Explosion and rupture of pressurised tyre, pipe or hose
0.648 0.352 0.000
W36 Explosion and rupture of gas cylinder
0.648 0.352 0.000
W35 Explosion and rupture of boiler
0.648 0.352 0.000
W34 Discharge from other and unspecified firearms
0.648 0.352 0.000
W33 Rifle, shotgun and larger firearm discharge
0.648 0.352 0.000
W32 Handgun discharge
0.648 0.352 0.000
W31 Contact with other and unspecified machinery
0.648 0.352 0.000
W30 Contact with agricultural machinery
0.648 0.352 0.000
W28 Contact with powered lawn mower
0.648 0.352 0.000
W27 Contact with nonpowered hand tool
0.648 0.352 0.000
W26 Contact with knife, sword or dagger
0.648 0.352 0.000
W25 Contact with sharp glass
0.648 0.352 0.000
W24 Contact with lifting and transmission devices, not elsewhere classified
0.648 0.352 0.000
W23 Caught, crushed, jammed or pinched in or between objects
0.648 0.352 0.000
W20 Struck by thrown, projected or falling object
0.648 0.352 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.647 0.353 0.000
I51.6 Cardiovascular disease, unspecified
0.646 0.354 0.000
I51.5 Myocardial degeneration
0.646 0.354 0.000
I51.4 Myocarditis, unspecified
0.646 0.354 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.646 0.354 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.646 0.354 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.646 0.354 0.000
I51.0 Cardiac septal defect, acquired
0.646 0.354 0.000
M47.82 Other spondylosis (Cervical region)
0.646 0.354 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.646 0.354 0.000
Q23 Congenital malformations of aortic and mitral valves
0.646 0.354 0.000
L08.8 Other specified local infections of skin and subcutaneous tissue
0.646 0.354 0.000
M23.8 Other internal derangements of knee
0.646 0.354 0.000
O34 Maternal care for known or suspected abnormality of pelvic organs
0.644 0.356 0.000
B99-B99 Other infectious diseases
0.643 0.356 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.643 0.356 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.643 0.356 0.000
B65-B83 Helminthiases
0.643 0.356 0.000
B50-B64 Protozoal diseases
0.643 0.356 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.643 0.356 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.643 0.356 0.000
A80-A89 Viral infections of the central nervous system
0.643 0.356 0.000
A75-A79 Rickettsioses
0.643 0.356 0.000
A70-A74 Other diseases caused by chlamydiae
0.643 0.356 0.000
A65-A69 Other spirochaetal diseases
0.643 0.356 0.000
A20-A28 Certain zoonotic bacterial diseases
0.643 0.356 0.000
A15-A19 Tuberculosis
0.643 0.356 0.000
O44 Placenta praevia
0.643 0.357 0.000
I46.0 Cardiac arrest with successful resuscitation
0.643 0.357 0.000
M79.87 Other specified soft tissue disorders (Ankle and foot)
0.642 0.358 0.000
M19.96 Arthrosis, unspecified-Lower leg
0.641 0.359 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.640 0.359 0.000
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft
0.638 0.362 0.000
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis
0.638 0.362 0.000
T82.4 Mechanical complication of vascular dialysis catheter
0.638 0.362 0.000
T82.3 Mechanical complication of other vascular grafts
0.638 0.362 0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts
0.638 0.362 0.000
T82.0 Mechanical complication of heart valve prosthesis
0.638 0.362 0.000
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.638 0.362 0.000
I83.0 Varicose veins of lower extremities with ulcer
0.638 0.362 0.000
S61.1 Open wound of finger(s) with damage to nail
0.638 0.362 0.000
I44 Atrioventricular and left bundle-branch block
0.637 0.362 0.000
Y85 Sequelae of transport accidents
0.637 0.363 0.000
O46 Antepartum haemorrhage, not elsewhere classified
0.637 0.363 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.636 0.364 0.000
M24 Other specific joint derangements
0.636 0.364 0.000
E28 Ovarian dysfunction
0.636 0.364 0.000
M79.67 Pain in limb (Ankle and foot)
0.635 0.364 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

This website was created, designed, and edited by ORCID iD iconPatrick K. Albers

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