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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs74880545
log Bayes Factor = 7.69301
Chromosome 21   position 29,997,493  (GRCh37) Explore rs74880545 on Ensembl!
Variant rs74880545 is part of Cluster X0160

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
M79 Other soft tissue disorders, not elsewhere classified
1.000 0.000 0.000
M70-M79 Other soft tissue disorders
1.000 0.000 0.000
M50-M54 Other dorsopathies
1.000 0.000 0.000
M79.66 Pain in limb (Lower leg)
1.000 0.000 0.000
M79.6 Pain in limb
1.000 0.000 0.000
M54 Dorsalgia
0.999 0.001 0.000
M54.5 Low back pain
0.997 0.003 0.000
M50 Cervical disk disorders
0.994 0.006 0.000
M54.57 Low back pain (Lumbosacral region)
0.970 0.030 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.946 0.054 0.000
M54.59 Low back pain (Site unspecified)
0.945 0.055 0.000
M20-M25 Other joint disorders
0.943 0.057 0.000
M79.1 Myalgia
0.928 0.072 0.000
M50.3 Other cervical disk degeneration
0.925 0.075 0.000
M86-M90 Other osteopathies
0.921 0.079 0.000
M91-M94 Chondropathies
0.919 0.081 0.000
M79.5 Residual foreign body in soft tissue
0.907 0.093 0.000
M54.9 Dorsalgia, unspecified
0.905 0.095 0.000
M54.1 Radiculopathy
0.902 0.098 0.000
M50.0 Cervical disk disorder with myelopathy
0.901 0.099 0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.890 0.110 0.000
M22 Disorders of patella
0.890 0.110 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.888 0.112 0.000
M65-M68 Disorders of synovium and tendon
0.881 0.119 0.000
M24 Other specific joint derangements
0.881 0.119 0.000
M79.61 Pain in limb (Shoulder region)
0.874 0.126 0.000
M50.2 Other cervical disk displacement
0.873 0.127 0.000
M05-M14 Inflammatory polyarthropathies
0.866 0.134 0.000
M79.9 Soft tissue disorder, unspecified
0.864 0.136 0.000
M50.1 Cervical disk disorder with radiculopathy
0.861 0.139 0.000
M15-M19 Arthrosis
0.860 0.140 0.000
M22.4 Chondromalacia patellae
0.853 0.147 0.000
M16 Coxarthrosis [arthrosis of hip]
0.845 0.155 0.000
M96.0 Pseudarthrosis after fusion or arthrodesis
0.842 0.158 0.000
M67 Other disorders of synovium and tendon
0.842 0.158 0.000
M79.54 Residual foreign body in soft tissue (Hand)
0.841 0.159 0.000
M54.16 Radiculopathy (Lumbar region)
0.841 0.159 0.000
M16.1 Other primary coxarthrosis
0.839 0.161 0.000
M05 Seropositive rheumatoid arthritis
0.835 0.165 0.000
M54.3 Sciatica
0.835 0.165 0.000
M54.58 Low back pain (Sacral and sacrococcygeal region)
0.834 0.166 0.000
M94 Other disorders of cartilage
0.831 0.169 0.000
M79.60 Pain in limb (Multiple sites)
0.827 0.173 0.000
M80-M85 Disorders of bone density and structure
0.823 0.177 0.000
M79.65 Pain in limb (Pelvic region and thigh)
0.822 0.178 0.000
M89 Other disorders of bone
0.816 0.184 0.000
M25 Other joint disorders, not elsewhere classified
0.814 0.186 0.000
M77 Other enthesopathies
0.814 0.186 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.813 0.187 0.000
M54.56 Low back pain (Lumbar region)
0.794 0.206 0.000
M79.62 Pain in limb (Upper arm)
0.793 0.207 0.000
M71 Other bursopathies
0.789 0.211 0.000
M54.50 Low back pain (Multiple sites in spine)
0.788 0.212 0.000
M79.18 Myalgia (Other)
0.787 0.213 0.000
M24.2 Disorder of ligament
0.782 0.218 0.000
M79.11 Myalgia (Shoulder region)
0.777 0.223 0.000
M88 Paget's disease of bone [osteitis deformans]
0.769 0.231 0.000
M94.8 Other specified disorders of cartilage
0.769 0.231 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.767 0.233 0.000
M79.96 Soft tissue disorder, unspecified (Lower leg)
0.767 0.233 0.000
M67.1 Other contracture of tendon (sheath)
0.763 0.237 0.000
M70.6 Trochanteric bursitis
0.757 0.243 0.000
M54.90 Dorsalgia, unspecified (Multiple sites in spine)
0.757 0.243 0.000
M70.4 Prepatellar bursitis
0.757 0.243 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.756 0.244 0.000
M54.93 Dorsalgia, unspecified (Cervicothoracic region)
0.753 0.247 0.000
M79.19 Myalgia (Site unspecified)
0.748 0.252 0.000
M16.0 Primary coxarthrosis, bilateral
0.746 0.254 0.000
M89.0 Algoneurodystrophy
0.746 0.254 0.000
M79.4 Hypertrophy of (infrapatellar) fat pad
0.745 0.255 0.000
M24.5 Contracture of joint
0.743 0.257 0.000
M10 Gout
0.742 0.258 0.000
M79.0 Rheumatism, unspecified
0.740 0.260 0.000
M76 Enthesopathies of lower limb, excluding foot
0.740 0.260 0.000
M00-M03 Infectious arthropathies
0.736 0.263 0.000
M87 Osteonecrosis
0.732 0.268 0.000
M30 Polyarteritis nodosa and related conditions
0.729 0.271 0.000
M34 Systemic sclerosis
0.718 0.282 0.000
M79.3 Panniculitis, unspecified
0.717 0.283 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.717 0.283 0.000
M79.68 Pain in limb (Other)
0.717 0.283 0.000
M54.55 Low back pain (Thoracolumbar region)
0.717 0.283 0.000
M54.8 Other dorsalgia
0.716 0.284 0.000
M54.0 Panniculitis affecting regions of neck and back
0.716 0.284 0.000
M54.54 Low back pain-Thoracic
0.715 0.285 0.000
M54.53 Low back pain-Cervicothoracic
0.715 0.285 0.000
M54.52 Low back pain-Cervical
0.715 0.285 0.000
M54.51 Low back pain-Occipit-atl-axl
0.715 0.285 0.000
M93 Other osteochondropathies
0.713 0.287 0.000
M60-M63 Disorders of muscles
0.713 0.287 0.000
M50.9 Cervical disk disorder, unspecified
0.712 0.288 0.000
M50.8 Other cervical disk disorders
0.712 0.288 0.000
M80 Osteoporosis with pathological fracture
0.709 0.291 0.000
M79.67 Pain in limb (Ankle and foot)
0.708 0.292 0.000
M24.1 Other articular cartilage disorders
0.708 0.292 0.000
M33 Dermatopolymyositis
0.708 0.292 0.000
M22.0 Recurrent dislocation of patella
0.706 0.294 0.000
M54.97 Dorsalgia, unspecified (Lumbosacral region)
0.703 0.297 0.000
M92 Other juvenile osteochondrosis
0.702 0.298 0.000
M67.2 Synovial hypertrophy, not elsewhere classified
0.701 0.299 0.000
M45-M49 Spondylopathies
0.701 0.299 0.000
M54.18 Radiculopathy (Sacral and sacrococcygeal region)
0.700 0.300 0.000
M94.88 Other specified disorders of cartilage (Other)
0.700 0.300 0.000
M67.8 Other specified disorders of synovium and tendon
0.699 0.301 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.697 0.303 0.000
M77.1 Lateral epicondylitis
0.693 0.307 0.000
M54.39 Sciatica (Site unspecified)
0.692 0.308 0.000
M54.19 Radiculopathy (Site unspecified)
0.690 0.310 0.000
M24.24 Disorder of ligament (Hand)
0.690 0.310 0.000
M22.2 Patellofemoral disorders
0.686 0.314 0.000
M53 Other dorsopathies, not elsewhere classified
0.685 0.315 0.000
M96.8 Other postprocedural musculoskeletal disorders
0.685 0.315 0.000
M79.10 Myalgia (Multiple sites)
0.679 0.321 0.000
M99 Biomechanical lesions, not elsewhere classified
0.678 0.322 0.000
M54.94 Dorsalgia, unspecified (Thoracic region)
0.677 0.323 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.676 0.324 0.000
M32 Systemic lupus erythematosus
0.676 0.324 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.675 0.325 0.000
M79.2 Neuralgia and neuritis, unspecified
0.671 0.329 0.000
M79.16 Myalgia (Lower leg)
0.668 0.332 0.000
M79.7 Fibromyalgia
0.666 0.334 0.000
M79.17 Myalgia (Ankle and foot)
0.665 0.335 0.000
M79.15 Myalgia (Pelvic region and thigh)
0.665 0.335 0.000
M79.14 Myalgia (Hand)
0.665 0.335 0.000
M79.13 Myalgia (Forearm)
0.665 0.335 0.000
M79.12 Myalgia (Upper arm)
0.665 0.335 0.000
M70.65 Trochanteric bursitis-Pelvic/Thigh
0.664 0.336 0.000
M25.0 Haemarthrosis
0.663 0.337 0.000
M25.8 Other specified joint disorders
0.663 0.337 0.000
M70.46 Prepatellar bursitis-Lower Leg
0.663 0.337 0.000
M54.98 Dorsalgia, unspecified (Sacral and sacrococcygeal region)
0.661 0.339 0.000
M71.2 Synovial cyst of popliteal space [Baker]
0.661 0.339 0.000
M88.9 Paget's disease of bone, unspecified
0.661 0.339 0.000
M91 Juvenile osteochondrosis of hip and pelvis
0.659 0.341 0.000
M21 Other acquired deformities of limbs
0.653 0.347 0.000
M10.9 Gout, unspecified
0.653 0.347 0.000
M79.59 Residual foreign body in soft tissue (Site unspecified)
0.650 0.349 0.000
M79.58 Residual foreign body in soft tissue (Other)
0.650 0.349 0.000
M79.57 Residual foreign body in soft tissue (Ankle and foot)
0.650 0.349 0.000
M79.56 Residual foreign body in soft tissue (Lower leg)
0.650 0.349 0.000
M79.55 Residual foreign body in soft tissue (Pelvic region and thigh)
0.650 0.349 0.000
M79.53 Residual foreign body in soft tissue (Forearm)
0.650 0.349 0.000
M79.52 Residual foreign body in soft tissue (Upper arm)
0.650 0.349 0.000
M79.51 Residual foreign body in soft tissue (Shoulder region)
0.650 0.349 0.000
M79.50 Residual foreign body in soft tissue (Multiple sites)
0.650 0.349 0.000
M25.4 Effusion of joint
0.650 0.350 0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.650 0.350 0.000
M54.95 Dorsalgia, unspecified (Thoracolumbar region)
0.649 0.351 0.000
M54.92 Dorsalgia, unspecified (Cervical region)
0.649 0.351 0.000
M54.91 Dorsalgia, unspecified (Occipito-atlanto-axial region)
0.649 0.351 0.000
M54.99 Dorsalgia, unspecified (Site unspecified)
0.649 0.351 0.000
M54.15 Radiculopathy (Thoracolumbar region)
0.646 0.354 0.000
M54.14 Radiculopathy (Thoracic region)
0.646 0.354 0.000
M54.13 Radiculopathy (Cervicothoracic region)
0.646 0.354 0.000
M54.11 Radiculopathy (Occipito-atlanto-axial region)
0.646 0.354 0.000
M54.10 Radiculopathy (Multiple sites in spine)
0.646 0.354 0.000
M89.06 Algoneurodystrophy (Lower leg)
0.645 0.355 0.000
M89.5 Osteolysis
0.642 0.357 0.000
M79.63 Pain in limb (Forearm)
0.641 0.359 0.000
M54.37 Sciatica (Lumbosacral region)
0.640 0.360 0.000
M96.6 Fracture of bone following insertion of orthopaedic implant, joint prosthesis or bone plate
0.638 0.361 0.000
M96.9 Postprocedural musculoskeletal disorder, unspecified
0.638 0.361 0.000
M96.5 Postradiation scoliosis
0.638 0.361 0.000
M96.4 Postsurgical lordosis
0.638 0.361 0.000
M96.3 Postlaminectomy kyphosis
0.638 0.361 0.000
M96.2 Postradiation kyphosis
0.638 0.361 0.000
M96.1 Postlaminectomy syndrome, not elsewhere classified
0.638 0.361 0.000
M22.1 Recurrent subluxation of patella
0.638 0.362 0.000
M22.9 Disorder of patella, unspecified
0.638 0.362 0.000
M70.9 Unspecified soft tissue disorder related to use, overuse and pressure
0.636 0.364 0.000
M70.8 Other soft tissue disorders related to use, overuse and pressure
0.636 0.364 0.000
M70.7 Other bursitis of hip
0.636 0.364 0.000
M70.5 Other bursitis of knee
0.636 0.364 0.000
M70.3 Other bursitis of elbow
0.636 0.364 0.000
M70.1 Bursitis of hand
0.636 0.364 0.000
M70.0 Chronic crepitant synovitis of hand and wrist
0.636 0.364 0.000
M25.9 Joint disorder, unspecified
0.636 0.364 0.000
M54.6 Pain in thoracic spine
0.633 0.367 0.000
M15 Polyarthrosis
0.633 0.367 0.000
M90 Osteopathies in diseases classified elsewhere
0.633 0.367 0.000
M77.0 Medial epicondylitis
0.633 0.367 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.632 0.368 0.000
M24.9 Joint derangement, unspecified
0.632 0.368 0.000
M24.7 Protrusio acetabuli
0.632 0.368 0.000
M24.6 Ankylosis of joint
0.632 0.368 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.632 0.368 0.000
M23 Internal derangement of knee
0.628 0.372 0.000
M16.7 Other secondary coxarthrosis
0.624 0.376 0.000
M82 Osteoporosis in diseases classified elsewhere
0.624 0.376 0.000
M25.7 Osteophyte
0.623 0.377 0.000
M86 Osteomyelitis
0.621 0.378 0.000
M12 Other specific arthropathies
0.621 0.379 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.621 0.379 0.000
M08 Juvenile arthritis
0.621 0.379 0.000
M87.9 Osteonecrosis, unspecified
0.620 0.380 0.000
M85 Other disorders of bone density and structure
0.620 0.380 0.000
M79.99 Soft tissue disorder, unspecified (Site unspecified)
0.620 0.380 0.000
M79.98 Soft tissue disorder, unspecified (Other)
0.620 0.380 0.000
M79.97 Soft tissue disorder, unspecified (Ankle and foot)
0.620 0.380 0.000
M79.95 Soft tissue disorder, unspecified (Pelvic region and thigh)
0.620 0.380 0.000
M79.94 Soft tissue disorder, unspecified (Hand)
0.620 0.380 0.000
M79.93 Soft tissue disorder, unspecified (Forearm)
0.620 0.380 0.000
M79.92 Soft tissue disorder, unspecified (Upper arm)
0.620 0.380 0.000
M79.91 Soft tissue disorder, unspecified (Shoulder region)
0.620 0.380 0.000
M79.90 Soft tissue disorder, unspecified (Multiple sites)
0.620 0.380 0.000
M25.3 Other instability of joint
0.619 0.381 0.000
M54.96 Dorsalgia, unspecified (Lumbar region)
0.616 0.384 0.000
M24.26 Disorder of ligament (Lower leg)
0.609 0.391 0.000
M45 Ankylosing spondylitis
0.608 0.392 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.608 0.392 0.000
M54.17 Radiculopathy (Lumbosacral region)
0.607 0.392 0.000
M25.75 Osteophyte (Pelvic region and thigh)
0.607 0.392 0.000
M77.12 Lateral epicondylitis (Upper arm)
0.607 0.393 0.000
M16.6 Other secondary coxarthrosis, bilateral
0.606 0.394 0.000
M16.4 Posttraumatic coxarthrosis, bilateral
0.606 0.394 0.000
M16.2 Coxarthrosis resulting from dysplasia, bilateral
0.606 0.394 0.000
M40-M43 Deforming dorsopathies
0.606 0.394 0.000
M89.09 Algoneurodystrophy (Site unspecified)
0.604 0.396 0.000
M67.9 Disorder of synovium and tendon, unspecified
0.603 0.396 0.000
M67.3 Transient synovitis
0.603 0.396 0.000
M67.0 Short Achilles tendon (acquired)
0.603 0.396 0.000
M54.38 Sciatica (Sacral and sacrococcygeal region)
0.601 0.398 0.000
M24.51 Contracture of joint (Shoulder region)
0.600 0.400 0.000
M67.4 Ganglion
0.599 0.401 0.000
M05.8 Other seropositive rheumatoid arthritis
0.599 0.401 0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.599 0.401 0.000
M05.2 Rheumatoid vasculitis
0.599 0.401 0.000
M05.1 Rheumatoid lung disease
0.599 0.401 0.000
M05.0 Felty's syndrome
0.599 0.401 0.000
M54.35 Sciatica (Thoracolumbar region)
0.598 0.401 0.000
M54.34 Sciatica-Thoracic
0.598 0.401 0.000
M54.33 Sciatica-Cervicothoracic
0.598 0.401 0.000
M54.32 Sciatica-Cervical
0.598 0.401 0.000
M54.31 Sciatica-Occipit-atl-axl
0.598 0.401 0.000
M54.30 Sciatica (Multiple sites in spine)
0.598 0.401 0.000
M94.89 Other specified disorders of cartilage (Site unspecified)
0.598 0.402 0.000
M94.9 Disorder of cartilage, unspecified
0.596 0.404 0.000
M94.3 Chondrolysis
0.596 0.404 0.000
M94.1 Relapsing polychondritis
0.596 0.404 0.000
M94.0 Chondrocostal junction syndrome [Tietze]
0.596 0.404 0.000
M16.5 Other posttraumatic coxarthrosis
0.596 0.404 0.000
M19 Other arthrosis
0.596 0.404 0.000
M07 Psoriatic and enteropathic arthropathies
0.596 0.404 0.000
M94.2 Chondromalacia
0.595 0.405 0.000
M89.03 Algoneurodystrophy (Forearm)
0.595 0.405 0.000
M31 Other necrotising vasculopathies
0.594 0.406 0.000
M54.36 Sciatica (Lumbar region)
0.593 0.407 0.000
M79.00 Rheumatism, unspecified (Multiple sites)
0.591 0.409 0.000
M95.2 Other acquired deformity of head
0.591 0.409 0.000
M70.2 Olecranon bursitis
0.590 0.410 0.000
M83 Adult osteomalacia
0.590 0.410 0.000
M94.86 Other specified disorders of cartilage (Lower leg)
0.589 0.411 0.000
M16.3 Other dysplastic coxarthrosis
0.589 0.411 0.000
M80.5 Idiopathic osteoporosis with pathological fracture
0.589 0.411 0.000
M71.1 Other infective bursitis
0.588 0.412 0.000
M24.54 Contracture of joint (Hand)
0.587 0.413 0.000
M79.08 Rheumatism, unspecified (Other)
0.586 0.414 0.000
M89.6 Osteopathy after poliomyelitis
0.585 0.414 0.000
M89.4 Other hypertrophic osteo-arthropathy
0.585 0.414 0.000
M89.3 Hypertrophy of bone
0.585 0.414 0.000
M89.2 Other disorders of bone development and growth
0.585 0.414 0.000
M89.1 Epiphyseal arrest
0.585 0.414 0.000
M80.0 Postmenopausal osteoporosis with pathological fracture
0.585 0.415 0.000
M10.97 Gout, unspecified (Ankle and foot)
0.584 0.416 0.000
M76.8 Other enthesopathies of lower limb, excluding foot
0.584 0.416 0.000
M25.2 Flail joint
0.583 0.416 0.000
M25.1 Fistula of joint
0.583 0.416 0.000
M77.8 Other enthesopathies, not elsewhere classified
0.583 0.417 0.000
M77.5 Other enthesopathy of foot
0.583 0.417 0.000
M77.3 Calcaneal spur
0.583 0.417 0.000
M77.2 Periarthritis of wrist
0.583 0.417 0.000
M24.11 Other articular cartilage disorders (Shoulder region)
0.583 0.417 0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.583 0.417 0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.583 0.417 0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.583 0.417 0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.583 0.417 0.000
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.583 0.417 0.000
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.583 0.417 0.000
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.583 0.417 0.000
M88.90 Paget's disease of bone, unspecified (Multiple sites)
0.583 0.417 0.000
M95.0 Acquired deformity of nose
0.581 0.419 0.000
M24.13 Other articular cartilage disorders (Forearm)
0.580 0.420 0.000
M81 Osteoporosis without pathological fracture
0.579 0.421 0.000
M11 Other crystal arthropathies
0.577 0.423 0.000
M23.8 Other internal derangements of knee
0.576 0.423 0.000
M30.1 Polyarteritis with lung involvement [Churg-Strauss]
0.576 0.423 0.000
M24.27 Disorder of ligament (Ankle and foot)
0.570 0.430 0.000
M22.3 Other derangements of patella
0.570 0.430 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.570 0.430 0.000
M71.26 Synovial cyst of popliteal space [Baker]-Lower Leg
0.569 0.431 0.000
M71.9 Bursopathy, unspecified
0.566 0.434 0.000
M71.8 Other specified bursopathies
0.566 0.434 0.000
M71.5 Other bursitis, not elsewhere classified
0.566 0.434 0.000
M71.4 Calcium deposit in bursa
0.566 0.434 0.000
M71.0 Abscess of bursa
0.566 0.434 0.000
M66 Spontaneous rupture of synovium and tendon
0.566 0.434 0.000
M93.9 Osteochondropathy, unspecified
0.565 0.435 0.000
M24.0 Loose body in joint
0.563 0.437 0.000
M79.46 Hypertrophy of (infrapatellar) fat pad (Lower leg)
0.562 0.438 0.000
M77.4 Metatarsalgia
0.562 0.438 0.000
M24.29 Disorder of ligament (Site unspecified)
0.560 0.439 0.000
M24.28 Disorder of ligament (Other)
0.560 0.439 0.000
M24.25 Disorder of ligament (Pelvic region and thigh)
0.560 0.439 0.000
M24.22 Disorder of ligament (Upper arm)
0.560 0.439 0.000
M24.21 Disorder of ligament (Shoulder region)
0.560 0.439 0.000
M24.20 Disorder of ligament (Multiple sites)
0.560 0.439 0.000
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.557 0.443 0.000
M79.64 Pain in limb (Hand)
0.556 0.444 0.000
M25.06 Haemarthrosis (Lower leg)
0.555 0.445 0.000
M89.9 Disorder of bone, unspecified
0.555 0.445 0.000
M24.23 Disorder of ligament (Forearm)
0.553 0.446 0.000
M22.8 Other disorders of patella
0.552 0.448 0.000
M88.8 Paget's disease of other bones
0.552 0.448 0.000
M88.0 Paget's disease of skull
0.552 0.448 0.000
M94.87 Other specified disorders of cartilage (Ankle and foot)
0.551 0.449 0.000
M94.85 Other specified disorders of cartilage (Pelvic region and thigh)
0.551 0.449 0.000
M94.84 Other specified disorders of cartilage (Hand)
0.551 0.449 0.000
M94.83 Other specified disorders of cartilage (Forearm)
0.551 0.449 0.000
M94.82 Other specified disorders of cartilage (Upper arm)
0.551 0.449 0.000
M94.81 Other specified disorders of cartilage (Shoulder region)
0.551 0.449 0.000
M94.80 Other specified disorders of cartilage (Multiple sites)
0.551 0.449 0.000
M87.8 Other osteonecrosis
0.551 0.449 0.000
M10.99 Gout, unspecified (Site unspecified)
0.550 0.450 0.000
M24.56 Contracture of joint (Lower leg)
0.548 0.452 0.000
M00 Pyogenic arthritis
0.548 0.452 0.000
M33.1 Other dermatomyositis
0.546 0.454 0.000
M92.7 Juvenile osteochondrosis of metatarsus
0.546 0.454 0.000
M14 Arthropathies in other diseases classified elsewhere
0.544 0.456 0.000
M70.69 Trochanteric bursitis-Site unspec
0.543 0.457 0.000
M70.68 Trochanteric bursitis-Other
0.543 0.457 0.000
M70.67 Trochanteric bursitis-Ankle/Foot
0.543 0.457 0.000
M70.66 Trochanteric bursitis-Lower Leg
0.543 0.457 0.000
M70.64 Trochanteric bursitis-Hand
0.543 0.457 0.000
M70.63 Trochanteric bursitis-Forearm
0.543 0.457 0.000
M70.62 Trochanteric bursitis-Upper arm
0.543 0.457 0.000
M70.61 Trochanteric bursitis-Shldr region
0.543 0.457 0.000
M70.60 Trochanteric bursitis-Mult sites
0.543 0.457 0.000
M70.49 Prepatellar bursitis-Site unspec
0.543 0.457 0.000
M70.48 Prepatellar bursitis-Other
0.543 0.457 0.000
M70.47 Prepatellar bursitis-Ankle/Foot
0.543 0.457 0.000
M70.45 Prepatellar bursitis-Pelvic/Thigh
0.543 0.457 0.000
M70.44 Prepatellar bursitis-Hand
0.543 0.457 0.000
M70.43 Prepatellar bursitis-Forearm
0.543 0.457 0.000
M70.42 Prepatellar bursitis-Upper arm
0.543 0.457 0.000
M70.41 Prepatellar bursitis-Shldr region
0.543 0.457 0.000
M70.40 Prepatellar bursitis-Mult sites
0.543 0.457 0.000
M95.9 Acquired deformity of musculoskeletal system, unspecified
0.542 0.458 0.000
M95.8 Other specified acquired deformities of musculoskeletal system
0.542 0.458 0.000
M95.5 Acquired deformity of pelvis
0.542 0.458 0.000
M95.4 Acquired deformity of chest and rib
0.542 0.458 0.000
M95.3 Acquired deformity of neck
0.542 0.458 0.000
M95.1 Cauliflower ear
0.542 0.458 0.000
M25.87 Other specified joint disorders (Ankle and foot)
0.541 0.459 0.000
M25.84 Other specified joint disorders (Hand)
0.539 0.461 0.000
M21.0 Valgus deformity, not elsewhere classified
0.539 0.461 0.000
M25.93 Joint disorder, unspecified (Forearm)
0.538 0.461 0.000
M34.1 CR(E)ST syndrome
0.538 0.462 0.000
M89.08 Algoneurodystrophy (Other)
0.535 0.465 0.000
M89.07 Algoneurodystrophy (Ankle and foot)
0.535 0.465 0.000
M89.05 Algoneurodystrophy (Pelvic region and thigh)
0.535 0.465 0.000
M89.02 Algoneurodystrophy (Upper arm)
0.535 0.465 0.000
M89.01 Algoneurodystrophy (Shoulder region)
0.535 0.465 0.000
M89.00 Algoneurodystrophy (Multiple sites)
0.535 0.465 0.000
M79.49 Hypertrophy of (infrapatellar) fat pad-Site unspec
0.534 0.466 0.000
M79.48 Hypertrophy of (infrapatellar) fat pad (Other)
0.534 0.466 0.000
M79.47 Hypertrophy of (infrapatellar) fat pad (Ankle and foot)
0.534 0.466 0.000
M79.45 Hypertrophy of (infrapatellar) fat pad (Pelvic region and thigh)
0.534 0.466 0.000
M79.44 Hypertrophy of (infrapatellar) fat pad (Hand)
0.534 0.466 0.000
M79.43 Hypertrophy of (infrapatellar) fat pad (Forearm)
0.534 0.466 0.000
M79.42 Hypertrophy of (infrapatellar) fat pad (Upper arm)
0.534 0.466 0.000
M79.41 Hypertrophy of (infrapatellar) fat pad (Shoulder region)
0.534 0.466 0.000
M79.40 Hypertrophy of (infrapatellar) fat pad (Multiple sites)
0.534 0.466 0.000
M24.59 Contracture of joint (Site unspecified)
0.533 0.467 0.000
M24.58 Contracture of joint (Other)
0.533 0.467 0.000
M24.57 Contracture of joint (Ankle and foot)
0.533 0.467 0.000
M24.55 Contracture of joint (Pelvic region and thigh)
0.533 0.467 0.000
M24.53 Contracture of joint (Forearm)
0.533 0.467 0.000
M24.52 Contracture of joint (Upper arm)
0.533 0.467 0.000
M24.50 Contracture of joint (Multiple sites)
0.533 0.467 0.000
M10.4 Other secondary gout
0.532 0.468 0.000
M10.3 Gout due to impairment of renal function
0.532 0.468 0.000
M10.2 Drug-induced gout
0.532 0.468 0.000
M10.1 Lead-induced gout
0.532 0.468 0.000
M10.0 Idiopathic gout
0.532 0.468 0.000
M80.9 Unspecified osteoporosis with pathological fracture
0.531 0.469 0.000
M76.9 Enthesopathy of lower limb, unspecified
0.531 0.469 0.000
M76.7 Peroneal tendinitis
0.531 0.469 0.000
M76.5 Patellar tendinitis
0.531 0.469 0.000
M76.4 Tibial collateral bursitis [Pellegrini-Stieda]
0.531 0.469 0.000
M76.3 Iliotibial band syndrome
0.531 0.469 0.000
M76.2 Iliac crest spur
0.531 0.469 0.000
M76.1 Psoas tendinitis
0.531 0.469 0.000
M76.0 Gluteal tendinitis
0.531 0.469 0.000
M79.07 Rheumatism, unspecified (Ankle and foot)
0.531 0.469 0.000
M79.06 Rheumatism, unspecified (Lower leg)
0.531 0.469 0.000
M79.05 Rheumatism, unspecified (Pelvic region and thigh)
0.531 0.469 0.000
M79.04 Rheumatism, unspecified (Hand)
0.531 0.469 0.000
M79.03 Rheumatism, unspecified (Forearm)
0.531 0.469 0.000
M79.02 Rheumatism, unspecified (Upper arm)
0.531 0.469 0.000
M79.01 Rheumatism, unspecified (Shoulder region)
0.531 0.469 0.000
M72 Fibroblastic disorders
0.530 0.470 0.000
M89.8 Other specified disorders of bone
0.529 0.471 0.000
M34.8 Other forms of systemic sclerosis
0.528 0.471 0.000
M03 Postinfective and reactive arthropathies in diseases classified elsewhere
0.528 0.472 0.000
M02 Reactive arthropathies
0.528 0.472 0.000
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere
0.528 0.472 0.000
M54.2 Cervicalgia
0.528 0.472 0.000
M60 Myositis
0.526 0.473 0.000
M89.04 Algoneurodystrophy (Hand)
0.525 0.474 0.000
M87.3 Other secondary osteonecrosis
0.525 0.475 0.000
M87.1 Osteonecrosis due to drugs
0.525 0.475 0.000
M87.0 Idiopathic aseptic necrosis of bone
0.525 0.475 0.000
M34.9 Systemic sclerosis, unspecified
0.524 0.476 0.000
M30.8 Other conditions related to polyarteritis nodosa
0.523 0.477 0.000
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]
0.523 0.477 0.000
M30.2 Juvenile polyarteritis
0.523 0.477 0.000
M30.0 Polyarteritis nodosa
0.523 0.477 0.000
M25.40 Effusion of joint (Multiple sites)
0.522 0.478 0.000
M23.4 Loose body in knee
0.521 0.479 0.000
M24.87 Other specific joint derangements, not elsewhere classified (Ankle and foot)
0.518 0.481 0.000
M89.55 Osteolysis (Pelvic region and thigh)
0.518 0.482 0.000
M49 Spondylopathies in diseases classified elsewhere
0.517 0.483 0.000
M77.9 Enthesopathy, unspecified
0.516 0.483 0.000
M25.74 Osteophyte (Hand)
0.516 0.484 0.000
M34.2 Systemic sclerosis induced by drugs and chemicals
0.515 0.485 0.000
M34.0 Progressive systemic sclerosis
0.515 0.485 0.000
M79.39 Panniculitis, unspecified (Site unspecified)
0.514 0.486 0.000
M79.38 Panniculitis, unspecified (Other)
0.514 0.486 0.000
M79.37 Panniculitis, unspecified (Ankle and foot)
0.514 0.486 0.000
M79.36 Panniculitis, unspecified (Lower leg)
0.514 0.486 0.000
M79.35 Panniculitis, unspecified (Pelvic region and thigh)
0.514 0.486 0.000
M79.34 Panniculitis, unspecified (Hand)
0.514 0.486 0.000
M79.33 Panniculitis, unspecified (Forearm)
0.514 0.486 0.000
M79.32 Panniculitis, unspecified (Upper arm)
0.514 0.486 0.000
M79.31 Panniculitis, unspecified (Shoulder region)
0.514 0.486 0.000
M79.30 Panniculitis, unspecified (Multiple sites)
0.514 0.486 0.000
M73.8 Other soft tissue disorders in diseases classified elsewhere
0.514 0.486 0.000
M73.1 Syphilitic bursitis
0.514 0.486 0.000
M73.0 Gonococcal bursitis
0.514 0.486 0.000
M54.09 Panniculitis affecting regions of neck and back (Site unspecified)
0.514 0.486 0.000
M54.08 Panniculitis affecting regions of neck and back (Sacral and sacrococcygeal region)
0.514 0.486 0.000
M54.07 Panniculitis affecting regions of neck and back (Lumbosacral region)
0.514 0.486 0.000
M54.06 Panniculitis affecting regions of neck and back (Lumbar region)
0.514 0.486 0.000
M54.05 Panniculitis affecting regions of neck and back (Thoracolumbar region)
0.514 0.486 0.000
M54.04 Panniculitis affecting regions of neck and back (Thoracic region)
0.514 0.486 0.000
M54.03 Panniculitis affecting regions of neck and back (Cervicothoracic region)
0.514 0.486 0.000
M54.02 Panniculitis affecting regions of neck and back (Cervical region)
0.514 0.486 0.000
M54.01 Panniculitis affecting regions of neck and back (Occipito-atlanto-axial region)
0.514 0.486 0.000
M54.00 Panniculitis affecting regions of neck and back (Multiple sites in spine)
0.514 0.486 0.000
M54.89 Other dorsalgia (Site unspecified)
0.514 0.486 0.000
M54.88 Other dorsalgia (Sacral and sacrococcygeal region)
0.514 0.486 0.000
M54.87 Other dorsalgia (Lumbosacral region)
0.514 0.486 0.000
M54.86 Other dorsalgia (Lumbar region)
0.514 0.486 0.000
M54.85 Other dorsalgia (Thoracolumbar region)
0.514 0.486 0.000
M54.84 Other dorsalgia (Thoracic region)
0.514 0.486 0.000
M54.83 Other dorsalgia (Cervicothoracic region)
0.514 0.486 0.000
M54.82 Other dorsalgia (Cervical region)
0.514 0.486 0.000
M54.81 Other dorsalgia (Occipito-atlanto-axial region)
0.514 0.486 0.000
M54.80 Other dorsalgia (Multiple sites in spine)
0.514 0.486 0.000
M23.80 Other internal derangements of knee (Multiple sites)
0.514 0.486 0.000
M87.95 Osteonecrosis, unspecified (Pelvic region and thigh)
0.511 0.489 0.000
M54.12 Radiculopathy (Cervical region)
0.511 0.489 0.000
M93.8 Other specified osteochondropathies
0.511 0.489 0.000
M93.2 Osteochondritis dissecans
0.511 0.489 0.000
M93.1 Kienbock's disease of adults
0.511 0.489 0.000
M93.0 Slipped upper femoral epiphysis (nontraumatic)
0.511 0.489 0.000
M63 Disorders of muscle in diseases classified elsewhere
0.511 0.489 0.000
M61 Calcification and ossification of muscle
0.511 0.489 0.000
M45.X2 Ankylosing spondylitis (Cervical region)
0.510 0.490 0.000
M80.8 Other osteoporosis with pathological fracture
0.509 0.491 0.000
M80.4 Drug-induced osteoporosis with pathological fracture
0.509 0.491 0.000
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture
0.509 0.491 0.000
M80.2 Osteoporosis of disuse with pathological fracture
0.509 0.491 0.000
M24.19 Other articular cartilage disorders (Site unspecified)
0.508 0.492 0.000
M24.18 Other articular cartilage disorders (Other)
0.508 0.492 0.000
M24.14 Other articular cartilage disorders (Hand)
0.508 0.492 0.000
M24.12 Other articular cartilage disorders (Upper arm)
0.508 0.492 0.000
M24.10 Other articular cartilage disorders (Multiple sites)
0.508 0.492 0.000
M33.9 Dermatopolymyositis, unspecified
0.508 0.492 0.000
M33.0 Juvenile dermatomyositis
0.508 0.492 0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)
0.506 0.494 0.000
M79.70 Fibromyalgia (Multiple sites)
0.505 0.494 0.000
M92.5 Juvenile osteochondrosis of tibia and fibula
0.503 0.497 0.000
M92.1 Juvenile osteochondrosis of radius and ulna
0.503 0.497 0.000
M92.9 Juvenile osteochondrosis, unspecified
0.503 0.497 0.000
M92.8 Other specified juvenile osteochondrosis
0.503 0.497 0.000
M92.6 Juvenile osteochondrosis of tarsus
0.503 0.497 0.000
M92.4 Juvenile osteochondrosis of patella
0.503 0.497 0.000
M92.3 Other juvenile osteochondrosis of upper limb
0.503 0.497 0.000
M92.2 Juvenile osteochondrosis of hand
0.503 0.497 0.000
M92.0 Juvenile osteochondrosis of humerus
0.503 0.497 0.000
M77.02 Medial epicondylitis (Upper arm)
0.503 0.497 0.000
M80.50 Idiopathic osteoporosis with pathological fracture (Multiple sites)
0.502 0.498 0.000
M19.0 Primary arthrosis of other joints
0.502 0.498 0.000
M45.X9 Ankylosing spondylitis (Site unspecified)
0.502 0.498 0.000
M24.15 Other articular cartilage disorders (Pelvic region and thigh)
0.501 0.499 0.000
M33.2 Polymyositis
0.500 0.500 0.000
M23.9 Internal derangement of knee, unspecified
0.499 0.501 0.000
M25.83 Other specified joint disorders (Forearm)
0.499 0.501 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

This website was created, designed, and edited by ORCID iD iconPatrick K. Albers

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