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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs77335750
log Bayes Factor = 14.1372
Chromosome 21   position 37,579,120  (GRCh37) Explore rs77335750 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
Chapter I Certain infectious and parasitic diseases
1.000 0.000 0.000
E11 Non-insulin-dependent diabetes mellitus
0.999 0.001 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.999 0.001 0.000
A00-A09 Intestinal infectious diseases
0.997 0.003 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.992 0.008 0.000
A09 Diarrhoea and gastro-enteritis of presumed infectious origin
0.991 0.009 0.000
A09.9 Gastroenteritis and colitis of unspecified origin
0.988 0.012 0.000
Chapter VI Diseases of the nervous system
0.987 0.013 0.000
E70-E90 Metabolic disorders
0.987 0.013 0.000
Chapter VII Diseases of the eye and adnexa
0.987 0.013 0.000
E11.3 With ophthalmic complications
0.980 0.020 0.000
Chapter VIII Diseases of the ear and mastoid process
0.978 0.022 0.000
Chapter X Diseases of the respiratory system
0.978 0.022 0.000
S60-S69 Injuries to the wrist and hand
0.969 0.031 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.968 0.032 0.000
H30-H36 Disorders of choroid and retina
0.965 0.035 0.000
E11.9 Without complications
0.956 0.044 0.000
B95-B98 Bacterial, viral and other infectious agents
0.951 0.049 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.949 0.051 0.000
H36 Retinal disorders in diseases classified elsewhere
0.948 0.052 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.940 0.060 0.000
G30-G32 Other degenerative diseases of the nervous system
0.937 0.063 0.000
H36.0 Diabetic retinopathy
0.936 0.064 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.935 0.065 0.000
E10 Insulin-dependent diabetes mellitus
0.935 0.065 0.000
S80-S89 Injuries to the knee and lower leg
0.933 0.067 0.000
J09-J18 Influenza and pneumonia
0.929 0.071 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.928 0.072 0.000
T40.2 Other opioids
0.922 0.078 0.000
E20-E35 Disorders of other endocrine glands
0.920 0.080 0.000
J40-J47 Chronic lower respiratory diseases
0.919 0.081 0.000
Chapter V Mental and behavioural disorders
0.918 0.082 0.000
A04 Other bacterial intestinal infections
0.916 0.084 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.913 0.087 0.000
H90-H95 Other disorders of ear
0.913 0.087 0.000
E65-E68 Obesity and other hyperalimentation
0.911 0.089 0.000
O34 Maternal care for known or suspected abnormality of pelvic organs
0.903 0.097 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.902 0.098 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.900 0.100 0.000
E11.5 With peripheral circulatory complications
0.898 0.102 0.000
O47 False labour
0.897 0.103 0.000
S82 Fracture of lower leg, including ankle
0.895 0.105 0.000
G90-G99 Other disorders of the nervous system
0.892 0.108 0.000
O80-O84 Delivery
0.882 0.118 0.000
G30 Alzheimer's disease
0.882 0.118 0.000
E83 Disorders of mineral metabolism
0.881 0.119 0.000
E86 Volume depletion
0.877 0.123 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.875 0.125 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.874 0.126 0.000
H92 Otalgia and effusion of ear
0.873 0.127 0.000
T43.2 Other and unspecified antidepressants
0.872 0.128 0.000
H43-H45 Disorders of vitreous body and globe
0.871 0.129 0.000
O47.1 False labour at or after 37 completed weeks of gestation
0.869 0.131 0.000
J60-J70 Lung diseases due to external agents
0.866 0.134 0.000
H10-H13 Disorders of conjunctiva
0.866 0.134 0.000
G62 Other polyneuropathies
0.864 0.136 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.863 0.137 0.000
E10.3 With ophthalmic complications
0.859 0.141 0.000
S62 Fracture at wrist and hand level
0.858 0.142 0.000
O60-O75 Complications of labour and delivery
0.858 0.142 0.000
H80-H83 Diseases of inner ear
0.853 0.147 0.000
S82.2 Fracture of shaft of tibia
0.850 0.150 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.849 0.151 0.000
H35 Other retinal disorders
0.846 0.154 0.000
S20-S29 Injuries to the thorax
0.844 0.156 0.000
J44 Other chronic obstructive pulmonary disease
0.843 0.157 0.000
G30.9 Alzheimer's disease, unspecified
0.843 0.157 0.000
E11.1 With ketoacidosis
0.842 0.158 0.000
H65-H75 Diseases of middle ear and mastoid
0.841 0.159 0.000
H92.0 Otalgia
0.841 0.159 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.839 0.161 0.000
T40.4 Other synthetic narcotics
0.837 0.163 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.836 0.164 0.000
Chapter XXI Factors influencing health status and contact with health services
0.836 0.164 0.000
S64 Injury of nerves at wrist and hand level
0.831 0.169 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.831 0.169 0.000
J15 Bacterial pneumonia, not elsewhere classified
0.828 0.172 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.827 0.173 0.000
M05-M14 Inflammatory polyarthropathies
0.827 0.173 0.000
J30-J39 Other diseases of upper respiratory tract
0.822 0.178 0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters
0.822 0.178 0.000
A30-A49 Other bacterial diseases
0.820 0.180 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.820 0.180 0.000
E66 Obesity
0.819 0.181 0.000
T42.4 Benzodiazepines
0.819 0.181 0.000
S82.20 Fracture of shaft of tibia (closed)
0.818 0.182 0.000
O34.1 Maternal care for tumour of corpus uteri
0.817 0.183 0.000
O43 Placental disorders
0.816 0.184 0.000
M10 Gout
0.814 0.186 0.000
G93 Other disorders of brain
0.812 0.188 0.000
E78.5 Hyperlipidaemia, unspecified
0.808 0.192 0.000
O34.2 Maternal care due to uterine scar from previous surgery
0.806 0.194 0.000
O00-O08 Pregnancy with abortive outcome
0.805 0.195 0.000
M10.9 Gout, unspecified
0.805 0.195 0.000
J13 Pneumonia due to Streptococcus pneumoniae
0.805 0.195 0.000
O85-O92 Complications predominantly related to the puerperium
0.804 0.196 0.000
M10.99 Gout, unspecified (Site unspecified)
0.801 0.199 0.000
B95.1 Streptococcus, group B, as the cause of diseases classified to other chapters
0.799 0.201 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.798 0.202 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.798 0.202 0.000
H04 Disorders of lachrymal system
0.796 0.204 0.000
E73 Lactose intolerance
0.796 0.204 0.000
Z60 Problems related to social environment
0.793 0.207 0.000
E87.0 Hyperosmolality and hypernatraemia
0.791 0.209 0.000
E66.8 Other obesity
0.791 0.209 0.000
E22 Hyperfunction of pituitary gland
0.791 0.209 0.000
F00 Dementia in Alzheimer's disease
0.791 0.209 0.000
H43 Disorders of vitreous body
0.790 0.210 0.000
B25-B34 Other viral diseases
0.790 0.210 0.000
A04.5 Campylobacter enteritis
0.785 0.215 0.000
B99-B99 Other infectious diseases
0.784 0.216 0.000
Chapter XXII Codes for special purposes
0.783 0.217 0.000
H01 Other inflammation of eyelid
0.783 0.217 0.000
E11.2 With renal complications
0.783 0.217 0.000
B65-B83 Helminthiases
0.782 0.218 0.000
J46 Status asthmaticus
0.782 0.218 0.000
E10.4 With neurological complications
0.782 0.218 0.000
J42 Unspecified chronic bronchitis
0.780 0.220 0.000
E27 Other disorders of adrenal gland
0.779 0.221 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.778 0.222 0.000
B98 Other specified infectious agents as the cause of diseases classified to other chapters
0.778 0.222 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.778 0.222 0.000
S81 Open wound of lower leg
0.776 0.224 0.000
Z60.2 Living alone
0.773 0.227 0.000
H35.3 Degeneration of macula and posterior pole
0.772 0.228 0.000
S62.3 Fracture of other metacarpal bone
0.772 0.228 0.000
G62.9 Polyneuropathy, unspecified
0.771 0.229 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.769 0.231 0.000
E11.6 With other specified complications
0.769 0.231 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.768 0.232 0.000
T51 Toxic effect of alcohol
0.766 0.234 0.000
G20-G26 Extrapyramidal and movement disorders
0.764 0.236 0.000
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.763 0.237 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.763 0.237 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.761 0.239 0.000
E83.3 Disorders of phosphorus metabolism
0.759 0.241 0.000
E83.4 Disorders of magnesium metabolism
0.758 0.242 0.000
E87.6 Hypokalaemia
0.757 0.243 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.756 0.244 0.000
B15-B19 Viral hepatitis
0.754 0.246 0.000
E10.1 With ketoacidosis
0.753 0.246 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.753 0.246 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.753 0.247 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.753 0.247 0.000
O80 Single spontaneous delivery
0.750 0.250 0.000
A04.8 Other specified bacterial intestinal infections
0.750 0.250 0.000
J10 Influenza due to identified influenza virus
0.750 0.250 0.000
E11.4 With neurological complications
0.748 0.252 0.000
H11 Other disorders of conjunctiva
0.747 0.253 0.000
G90 Disorders of autonomic nervous system
0.747 0.253 0.000
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.747 0.253 0.000
E87.7 Fluid overload
0.746 0.253 0.000
H90 Conductive and sensorineural hearing loss
0.745 0.255 0.000
H81 Disorders of vestibular function
0.743 0.257 0.000
S10-S19 Injuries to the neck
0.743 0.257 0.000
O35 Maternal care for known or suspected foetal abnormality and damage
0.741 0.259 0.000
H00 Hordeolum and chalazion
0.739 0.261 0.000
J11 Influenza, virus not identified
0.737 0.263 0.000
J36 Peritonsillar abscess
0.737 0.263 0.000
A04.7 Enterocolitis due to Clostridium difficile
0.735 0.265 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.735 0.265 0.000
E65 Localised adiposity
0.734 0.266 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.733 0.267 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.732 0.268 0.000
F00.9 Dementia in Alzheimer's disease, unspecified
0.730 0.270 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.730 0.270 0.000
G93.8 Other specified disorders of brain
0.729 0.271 0.000
G62.8 Other specified polyneuropathies
0.729 0.271 0.000
S68 Traumatic amputation of wrist and hand
0.728 0.272 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.727 0.273 0.000
J17 Pneumonia in diseases classified elsewhere
0.726 0.274 0.000
A08 Viral and other specified intestinal infections
0.725 0.275 0.000
G60 Hereditary and idiopathic neuropathy
0.725 0.275 0.000
J69 Pneumonitis due to solids and liquids
0.723 0.277 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.722 0.278 0.000
H55-H59 Other disorders of eye and adnexa
0.721 0.279 0.000
J32 Chronic sinusitis
0.721 0.279 0.000
O43.1 Malformation of placenta
0.721 0.279 0.000
G61 Inflammatory polyneuropathy
0.720 0.280 0.000
O82 Single delivery by Caesarean section
0.720 0.280 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.719 0.281 0.000
E28 Ovarian dysfunction
0.719 0.281 0.000
S82.6 Fracture of lateral malleolus
0.718 0.282 0.000
B95.7 Other staphylococcus as the cause of diseases classified to other chapters
0.718 0.282 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.718 0.282 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.717 0.283 0.000
E40-E46 Malnutrition
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.717 0.283 0.000
B50-B64 Protozoal diseases
0.717 0.283 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.717 0.283 0.000
A75-A79 Rickettsioses
0.717 0.283 0.000
A70-A74 Other diseases caused by chlamydiae
0.717 0.283 0.000
A65-A69 Other spirochaetal diseases
0.717 0.283 0.000
A20-A28 Certain zoonotic bacterial diseases
0.717 0.283 0.000
A15-A19 Tuberculosis
0.717 0.283 0.000
E11.8 With unspecified complications
0.716 0.283 0.000
E11.7 With multiple complications
0.716 0.283 0.000
E11.0 With coma
0.716 0.283 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.717 0.283 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.716 0.284 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.716 0.284 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.716 0.284 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.716 0.284 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.716 0.284 0.000
T36 Poisoning by systemic antibiotics
0.716 0.284 0.000
S82.0 Fracture of patella
0.716 0.284 0.000
A07 Other protozoal intestinal diseases
0.715 0.285 0.000
A06 Amoebiasis
0.715 0.285 0.000
A05 Other bacterial foodborne intoxications
0.715 0.285 0.000
A03 Shigellosis
0.715 0.285 0.000
A02 Other Salmonella infections
0.715 0.285 0.000
A01 Typhoid and paratyphoid fevers
0.715 0.285 0.000
A00 Cholera
0.715 0.285 0.000
S63.4 Traumatic rupture of ligament of finger at metacarpophalangeal and interphalangeal joint(s)
0.715 0.285 0.000
S82.5 Fracture of medial malleolus
0.714 0.286 0.000
Z57 Occupational exposure to risk-factors
0.712 0.288 0.000
T79-T79 Certain early complications of trauma
0.712 0.288 0.000
A49 Bacterial infection of unspecified site
0.711 0.289 0.000
H83 Other diseases of inner ear
0.711 0.289 0.000
F99-F99 Unspecified mental disorder
0.711 0.289 0.000
S62.30 Fracture of other metacarpal bone (closed)
0.710 0.290 0.000
H65 Nonsuppurative otitis media
0.710 0.290 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.709 0.291 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.709 0.291 0.000
S67 Crushing injury of wrist and hand
0.708 0.292 0.000
E85 Amyloidosis
0.708 0.292 0.000
E84 Cystic fibrosis
0.708 0.292 0.000
E79 Disorders of purine and pyrimidine metabolism
0.708 0.292 0.000
E77 Disorders of glycoprotein metabolism
0.708 0.292 0.000
E76 Disorders of glycosaminoglycan metabolism
0.708 0.292 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.708 0.292 0.000
E74 Other disorders of carbohydrate metabolism
0.708 0.292 0.000
E72 Other disorders of amino-acid metabolism
0.708 0.292 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.708 0.292 0.000
E70 Disorders of aromatic amino-acid metabolism
0.708 0.292 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.708 0.292 0.000
T92 Sequelae of injuries of upper limb
0.707 0.292 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.706 0.294 0.000
E87.2 Acidosis
0.706 0.294 0.000
M06 Other rheumatoid arthritis
0.705 0.295 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.704 0.296 0.000
E13 Other specified diabetes mellitus
0.703 0.297 0.000
E10.5 With peripheral circulatory complications
0.703 0.297 0.000
S64.3 Injury of digital nerve of thumb
0.701 0.299 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.700 0.299 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.700 0.300 0.000
H01.0 Blepharitis
0.699 0.301 0.000
J45 Asthma
0.698 0.302 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.698 0.302 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.698 0.302 0.000
E14 Unspecified diabetes mellitus
0.697 0.303 0.000
J40 Bronchitis, not specified as acute or chronic
0.697 0.303 0.000
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified
0.696 0.304 0.000
S65 Injury of blood vessels at wrist and hand level
0.694 0.305 0.000
T39.1 4-Aminophenol derivatives
0.694 0.306 0.000
A80-A89 Viral infections of the central nervous system
0.694 0.306 0.000
T40.9 Other and unspecified psychodysleptics [hallucinogens]
0.694 0.306 0.000
T40.8 Lysergide [LSD]
0.694 0.306 0.000
T40.7 Cannabis (derivatives)
0.694 0.306 0.000
T40.6 Other and unspecified narcotics
0.694 0.306 0.000
T40.5 Cocaine
0.694 0.306 0.000
T40.3 Methadone
0.694 0.306 0.000
T40.1 Heroin
0.694 0.306 0.000
T40.0 Opium
0.694 0.306 0.000
J61 Pneumoconiosis due to asbestos and other mineral fibres
0.692 0.308 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.692 0.308 0.000
H31 Other disorders of choroid
0.692 0.308 0.000
H30 Chorioretinal inflammation
0.692 0.308 0.000
T98 Sequelae of other and unspecified effects of external causes
0.692 0.308 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.690 0.309 0.000
J15.5 Pneumonia due to Escherichia coli
0.691 0.309 0.000
H71 Cholesteatoma of middle ear
0.690 0.310 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.689 0.311 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.689 0.311 0.000
H60-H62 Diseases of external ear
0.687 0.313 0.000
F02 Dementia in other diseases classified elsewhere
0.687 0.313 0.000
O62 Abnormalities of forces of labour
0.687 0.313 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
0.686 0.314 0.000
H10 Conjunctivitis
0.686 0.314 0.000
O41 Other disorders of amniotic fluid and membranes
0.685 0.315 0.000
G93.6 Cerebral oedema
0.684 0.316 0.000
J20-J22 Other acute lower respiratory infections
0.682 0.318 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.681 0.318 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.681 0.319 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.681 0.319 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.681 0.319 0.000
T66-T78 Other and unspecified effects of external causes
0.680 0.320 0.000
O45 Premature separation of placenta [abruptio placentae]
0.680 0.320 0.000
O44 Placenta praevia
0.680 0.320 0.000
O33 Maternal care for known or suspected disproportion
0.680 0.320 0.000
O31 Complications specific to multiple gestation
0.680 0.320 0.000
O40 Polyhydramnios
0.680 0.320 0.000
F60-F69 Disorders of adult personality and behaviour
0.680 0.320 0.000
H36.8 Other retinal disorders in diseases classified elsewhere
0.680 0.320 0.000
H05 Disorders of orbit
0.678 0.321 0.000
J39 Other diseases of upper respiratory tract
0.678 0.322 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.677 0.322 0.000
O69 Labour and delivery complicated by umbilical cord complications
0.677 0.323 0.000
Chapter XIV Diseases of the genitourinary system
0.677 0.323 0.000
O80.9 Single spontaneous delivery, unspecified
0.677 0.323 0.000
O04 Medical abortion
0.675 0.325 0.000
S66.3 Injury of extensor muscle and tendon of other finger at wrist and hand level
0.675 0.325 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.675 0.325 0.000
J95-J99 Other diseases of the respiratory system
0.675 0.325 0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.674 0.326 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.674 0.326 0.000
T42.5 Mixed antiepileptics, not elsewhere classified
0.674 0.326 0.000
T42.3 Barbiturates
0.674 0.326 0.000
T42.2 Succinimides and oxazolidinediones
0.674 0.326 0.000
T42.1 Iminostilbenes
0.674 0.326 0.000
T42.0 Hydantoin derivatives
0.674 0.326 0.000
S69 Other and unspecified injuries of wrist and hand
0.674 0.326 0.000
J67 Hypersensitivity pneumonitis due to organic dust
0.673 0.327 0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.672 0.328 0.000
S64.0 Injury of ulnar nerve at wrist and hand level
0.671 0.329 0.000
G64 Other disorders of peripheral nervous system
0.671 0.329 0.000
F80-F89 Disorders of psychological development
0.670 0.329 0.000
E10.8 With unspecified complications
0.670 0.329 0.000
E10.7 With multiple complications
0.670 0.329 0.000
E10.6 With other specified complications
0.670 0.329 0.000
E10.2 With renal complications
0.670 0.329 0.000
E10.0 With coma
0.670 0.329 0.000
H43.8 Other disorders of vitreous body
0.670 0.330 0.000
S88 Traumatic amputation of lower leg
0.669 0.331 0.000
S87 Crushing injury of lower leg
0.669 0.331 0.000
S86 Injury of muscle and tendon at lower leg level
0.669 0.331 0.000
S85 Injury of blood vessels at lower leg level
0.669 0.331 0.000
S84 Injury of nerves at lower leg level
0.669 0.331 0.000
G70-G73 Diseases of myoneural junction and muscle
0.669 0.331 0.000
H04.5 Stenosis and insufficiency of lachrymal passages
0.668 0.332 0.000
S62.2 Fracture of first metacarpal bone
0.668 0.332 0.000
F03 Unspecified dementia
0.667 0.333 0.000
T91 Sequelae of injuries of neck and trunk
0.667 0.333 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.666 0.334 0.000
J16 Pneumonia due to other infectious organisms, not elsewhere classified
0.666 0.334 0.000
J12 Viral pneumonia, not elsewhere classified
0.666 0.334 0.000
J14 Pneumonia due to Haemophilus influenzae
0.666 0.334 0.000
J09 Influenza due to certain identified influenza virus
0.666 0.334 0.000
T43.9 Psychotropic drug, unspecified
0.666 0.334 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.666 0.334 0.000
T43.6 Psychostimulants with abuse potential
0.666 0.334 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.666 0.334 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.666 0.334 0.000
B95.0 Streptococcus, group A, as the cause of diseases classified to other chapters
0.665 0.334 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.665 0.335 0.000
H43.1 Vitreous haemorrhage
0.665 0.335 0.000
M14 Arthropathies in other diseases classified elsewhere
0.664 0.336 0.000
N17-N19 Renal failure
0.664 0.336 0.000
J34 Other disorders of nose and nasal sinuses
0.664 0.336 0.000
S22.4 Multiple fractures of ribs
0.662 0.338 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.662 0.338 0.000
M05 Seropositive rheumatoid arthritis
0.662 0.338 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.661 0.339 0.000
F01 Vascular dementia
0.660 0.340 0.000
S62.4 Multiple fractures of metacarpal bones
0.660 0.340 0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease
0.660 0.340 0.000
A09.0 Other and unspecified gastroenteritis and colitis of infectious origin
0.660 0.340 0.000
J15.4 Pneumonia due to other streptococci
0.660 0.340 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.659 0.340 0.000
E34 Other endocrine disorders
0.659 0.340 0.000
E32 Diseases of thymus
0.659 0.340 0.000
E31 Polyglandular dysfunction
0.659 0.340 0.000
E30 Disorders of puberty, not elsewhere classified
0.659 0.340 0.000
E26 Hyperaldosteronism
0.659 0.340 0.000
E25 Adrenogenital disorders
0.659 0.340 0.000
E24 Cushing's syndrome
0.659 0.340 0.000
E20 Hypoparathyroidism
0.659 0.340 0.000
F30-F39 Mood [affective] disorders
0.659 0.341 0.000
E73.9 Lactose intolerance, unspecified
0.659 0.341 0.000
E50-E64 Other nutritional deficiencies
0.659 0.341 0.000
O72 Postpartum haemorrhage
0.659 0.341 0.000
E23 Hypofunction and other disorders of pituitary gland
0.659 0.341 0.000
J41 Simple and mucopurulent chronic bronchitis
0.659 0.341 0.000
H35.5 Hereditary retinal dystrophy
0.659 0.341 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.658 0.341 0.000
F70-F79 Mental retardation
0.658 0.341 0.000
E88 Other metabolic disorders
0.658 0.342 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.658 0.342 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.657 0.343 0.000
A04.9 Bacterial intestinal infection, unspecified
0.657 0.343 0.000
A04.6 Enteritis due to Yersinia enterocolitica
0.657 0.343 0.000
A04.4 Other intestinal Escherichia coli infections
0.657 0.343 0.000
A04.3 Enterohaemorrhagic Escherichia coli infection
0.657 0.343 0.000
A04.2 Enteroinvasive Escherichia coli infection
0.657 0.343 0.000
A04.1 Enterotoxigenic Escherichia coli infection
0.657 0.343 0.000
A04.0 Enteropathogenic Escherichia coli infection
0.657 0.343 0.000
S60 Superficial injury of wrist and hand
0.656 0.343 0.000
H92.1 Otorrhoea
0.656 0.344 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.656 0.344 0.000
H34 Retinal vascular occlusions
0.656 0.344 0.000
E87.4 Mixed disorder of acid-base balance
0.655 0.345 0.000
E87.3 Alkalosis
0.655 0.345 0.000
H94 Other disorders of ear in diseases classified elsewhere
0.655 0.345 0.000
T47.1 Other antacids and anti-gastric-secretion drugs
0.654 0.346 0.000
J15.1 Pneumonia due to Pseudomonas
0.654 0.346 0.000
S66.2 Injury of extensor muscle and tendon of thumb at wrist and hand level
0.654 0.346 0.000
B98.0 Helicobacter pylori [H.pylori] as the cause of diseases classified to other chapters
0.654 0.346 0.000
H04.2 Epiphora
0.654 0.346 0.000
T90 Sequelae of injuries of head
0.654 0.346 0.000
H81.0 Meniere's disease
0.654 0.346 0.000
E67 Other hyperalimentation
0.653 0.346 0.000
E68 Sequelae of hyperalimentation
0.653 0.346 0.000
B95.5 Unspecified streptococcus as the cause of diseases classified to other chapters
0.653 0.347 0.000
B95.3 Streptococcus pneumoniae as the cause of diseases classified to other chapters
0.653 0.347 0.000
E27.1 Primary adrenocortical insufficiency
0.652 0.348 0.000
Z57.5 Occupational exposure to toxic agents in other industries
0.651 0.349 0.000
O81 Single delivery by forceps and vacuum extractor
0.651 0.349 0.000
O90 Complications of the puerperium, not elsewhere classified
0.650 0.350 0.000
M40-M43 Deforming dorsopathies
0.649 0.351 0.000
O34.9 Maternal care for abnormality of pelvic organ, unspecified
0.647 0.352 0.000
O34.8 Maternal care for other abnormalities of pelvic organs
0.647 0.352 0.000
O34.7 Maternal care for abnormality of vulva and perineum
0.647 0.352 0.000
O34.6 Maternal care for abnormality of vagina
0.647 0.352 0.000
O34.5 Maternal care for other abnormalities of gravid uterus
0.647 0.352 0.000
O34.4 Maternal care for other abnormalities of cervix
0.647 0.352 0.000
O34.3 Maternal care for cervical incompetence
0.647 0.352 0.000
O34.0 Maternal care for congenital malformation of uterus
0.647 0.352 0.000
O71 Other obstetric trauma
0.647 0.353 0.000
B95.2 Streptococcus, group D, as the cause of diseases classified to other chapters
0.647 0.353 0.000
N18 Chronic renal failure
0.646 0.354 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.645 0.355 0.000
T51.0 Ethanol
0.645 0.355 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.644 0.356 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.644 0.356 0.000
G90.0 Idiopathic peripheral autonomic neuropathy
0.644 0.356 0.000
S82.8 Fractures of other parts of lower leg
0.644 0.356 0.000
S62.8 Fracture of other and unspecified parts of wrist and hand
0.644 0.356 0.000
O47.0 False labour before 37 completed weeks of gestation
0.643 0.357 0.000
O67.9 Intrapartum haemorrhage, unspecified
0.643 0.357 0.000
H66 Suppurative and unspecified otitis media
0.642 0.358 0.000
T51.9 Alcohol, unspecified
0.642 0.358 0.000
Z56 Problems related to employment and unemployment
0.642 0.358 0.000
S82.9 Fracture of lower leg, part unspecified
0.641 0.359 0.000
S82.7 Multiple fractures of lower leg
0.641 0.359 0.000
S82.3 Fracture of lower end of tibia
0.640 0.360 0.000
G96 Other disorders of central nervous system
0.639 0.361 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.639 0.361 0.000
G92 Toxic encephalopathy
0.639 0.361 0.000
A48 Other bacterial diseases, not elsewhere classified
0.638 0.362 0.000
H35.6 Retinal haemorrhage
0.637 0.362 0.000
H35.7 Separation of retinal layers
0.637 0.363 0.000
S27 Injury of other and unspecified intrathoracic organs
0.636 0.364 0.000
H00.0 Hordeolum and other deep inflammation of eyelid
0.634 0.366 0.000
H11.4 Other conjunctival vascular disorders and cysts
0.634 0.366 0.000
O75.7 Vaginal delivery following previous Caesarean section
0.634 0.366 0.000
S50-S59 Injuries to the elbow and forearm
0.633 0.366 0.000
O84 Multiple delivery
0.632 0.368 0.000
O83 Other assisted single delivery
0.632 0.368 0.000
T93 Sequelae of injuries of lower limb
0.632 0.368 0.000
G30.8 Other Alzheimer's disease
0.632 0.368 0.000
G30.1 Alzheimer's disease with late onset
0.632 0.368 0.000
G30.0 Alzheimer's disease with early onset
0.632 0.368 0.000
S81.0 Open wound of knee
0.632 0.368 0.000
S63.6 Sprain and strain of finger(s)
0.632 0.368 0.000
E83.9 Disorder of mineral metabolism, unspecified
0.632 0.368 0.000
E83.8 Other disorders of mineral metabolism
0.632 0.368 0.000
E83.2 Disorders of zinc metabolism
0.632 0.368 0.000
E83.0 Disorders of copper metabolism
0.632 0.368 0.000
O30 Multiple gestation
0.629 0.371 0.000
B99 Other and unspecified infectious diseases
0.629 0.371 0.000
O03 Spontaneous abortion
0.629 0.371 0.000
O61 Failed induction of labour
0.628 0.372 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.627 0.372 0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction
0.627 0.372 0.000
F09 Unspecified organic or symptomatic mental disorder
0.627 0.372 0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances
0.627 0.372 0.000
O75.6 Delayed delivery after spontaneous or unspecified rupture of membranes
0.627 0.373 0.000
T95 Sequelae of burns, corrosions and frostbite
0.627 0.373 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.627 0.373 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.627 0.373 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.627 0.373 0.000
B80 Enterobiasis
0.627 0.373 0.000
H92.2 Otorrhagia
0.626 0.374 0.000
E83.1 Disorders of iron metabolism
0.626 0.374 0.000
Z73 Problems related to life-management difficulty
0.625 0.375 0.000
M65-M68 Disorders of synovium and tendon
0.625 0.375 0.000
G20 Parkinson's disease
0.625 0.375 0.000
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.625 0.375 0.000
S90-S99 Injuries to the ankle and foot
0.624 0.376 0.000
A49.0 Staphylococcal infection, unspecified
0.623 0.377 0.000
H11.9 Disorder of conjunctiva, unspecified
0.623 0.377 0.000
O82.1 Delivery by emergency Caesarean section
0.623 0.377 0.000
J70 Respiratory conditions due to other external agents
0.621 0.379 0.000
J68 Respiratory conditions due to inhalation of chemicals, gases, fumes and vapours
0.621 0.379 0.000
J66 Airway disease due to specific organic dust
0.621 0.379 0.000
J63 Pneumoconiosis due to other inorganic dusts
0.621 0.379 0.000
J62 Pneumoconiosis due to dust containing silica
0.621 0.379 0.000
J65 Pneumoconiosis associated with tuberculosis
0.621 0.379 0.000
J64 Unspecified pneumoconiosis
0.621 0.379 0.000
J60 Coalworker's pneumoconiosis
0.621 0.379 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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