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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs77468433
log Bayes Factor = 17.4594
Chromosome 1   position 77,140,699  (GRCh37) Explore rs77468433 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter XIV Diseases of the genitourinary system
1.000 0.000 0.000
Chapter XI Diseases of the digestive system
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
K80-K87 Disorders of gallbladder, biliary tract and pancreas
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
0.999 0.001 0.000
E70-E90 Metabolic disorders
0.999 0.001 0.000
N80-N98 Noninflammatory disorders of female genital tract
0.998 0.002 0.000
I30-I52 Other forms of heart disease
0.998 0.002 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.997 0.003 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.997 0.003 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.996 0.004 0.000
E78.0 Pure hypercholesterolaemia
0.996 0.004 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.994 0.006 0.000
L60-L75 Disorders of skin appendages
0.992 0.008 0.000
L72 Follicular cysts of skin and subcutaneous tissue
0.990 0.010 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.989 0.011 0.000
D50-D53 Nutritional anaemias
0.988 0.012 0.000
L72.1 Trichilemmal cyst
0.987 0.013 0.000
N60-N64 Disorders of breast
0.987 0.013 0.000
K80 Cholelithiasis
0.986 0.014 0.000
D51 Vitamin B12 deficiency anaemia
0.986 0.014 0.000
E10-E14 Diabetes mellitus
0.985 0.015 0.000
I20-I25 Ischaemic heart diseases
0.984 0.016 0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.980 0.020 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.974 0.026 0.000
E11 Non-insulin-dependent diabetes mellitus
0.972 0.028 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.968 0.032 0.000
N17-N19 Renal failure
0.961 0.039 0.000
E11.9 Without complications
0.961 0.039 0.000
K50-K52 Noninfective enteritis and colitis
0.960 0.040 0.000
K83 Other diseases of biliary tract
0.960 0.040 0.000
N60 Benign mammary dysplasia
0.960 0.040 0.000
R00 Abnormalities of heart beat
0.959 0.041 0.000
I35 Nonrheumatic aortic valve disorders
0.950 0.050 0.000
K80.1 Calculus of gallbladder with other cholecystitis
0.949 0.051 0.000
I50 Heart failure
0.945 0.055 0.000
R00.2 Palpitations
0.945 0.055 0.000
N92 Excessive, frequent and irregular menstruation
0.941 0.059 0.000
N93 Other abnormal uterine and vaginal bleeding
0.937 0.063 0.000
Chapter VII Diseases of the eye and adnexa
0.936 0.064 0.000
N94 Pain and other conditions associated with female genital organs and menstrual cycle
0.936 0.064 0.000
I44 Atrioventricular and left bundle-branch block
0.935 0.065 0.000
N92.1 Excessive and frequent menstruation with irregular cycle
0.935 0.065 0.000
K82 Other diseases of gallbladder
0.933 0.067 0.000
I20 Angina pectoris
0.929 0.071 0.000
K70-K77 Diseases of liver
0.922 0.078 0.000
I51 Complications and ill-defined descriptions of heart disease
0.920 0.080 0.000
K83.1 Obstruction of bile duct
0.919 0.081 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.918 0.082 0.000
Chapter XXI Factors influencing health status and contact with health services
0.913 0.087 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.907 0.093 0.000
Chapter VI Diseases of the nervous system
0.907 0.093 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.899 0.101 0.000
R02 Gangrene, not elsewhere classified
0.898 0.102 0.000
H30-H36 Disorders of choroid and retina
0.898 0.102 0.000
K80.0 Calculus of gallbladder with acute cholecystitis
0.895 0.105 0.000
K50 Crohn's disease [regional enteritis]
0.893 0.107 0.000
S60-S69 Injuries to the wrist and hand
0.892 0.108 0.000
N18 Chronic renal failure
0.892 0.108 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.885 0.115 0.000
R50-R69 General symptoms and signs
0.883 0.117 0.000
N93.0 Postcoital and contact bleeding
0.881 0.119 0.000
N94.6 Dysmenorrhoea, unspecified
0.878 0.122 0.000
I21 Acute myocardial infarction
0.876 0.124 0.000
R53 Malaise and fatigue
0.875 0.125 0.000
I44.2 Atrioventricular block, complete
0.873 0.127 0.000
K51 Ulcerative colitis
0.871 0.129 0.000
S90-S99 Injuries to the ankle and foot
0.871 0.129 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.868 0.132 0.000
N90 Other noninflammatory disorders of vulva and perineum
0.867 0.133 0.000
N10-N16 Renal tubulo-interstitial diseases
0.867 0.133 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.866 0.134 0.000
K90-K93 Other diseases of the digestive system
0.864 0.136 0.000
I50.0 Congestive heart failure
0.863 0.137 0.000
N19 Unspecified renal failure
0.862 0.138 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.860 0.140 0.000
H35 Other retinal disorders
0.856 0.144 0.000
N63 Unspecified lump in breast
0.854 0.146 0.000
K85 Acute pancreatitis
0.853 0.147 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.852 0.148 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.850 0.150 0.000
R00.0 Tachycardia, unspecified
0.848 0.152 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.844 0.156 0.000
G90-G99 Other disorders of the nervous system
0.843 0.157 0.000
Z00-Z13 Persons encountering health services for examination and investigation
0.842 0.158 0.000
K74 Fibrosis and cirrhosis of liver
0.840 0.160 0.000
N93.9 Abnormal uterine and vaginal bleeding, unspecified
0.837 0.163 0.000
R07 Pain in throat and chest
0.837 0.163 0.000
R01 Cardiac murmurs and other cardiac sounds
0.836 0.164 0.000
I20.0 Unstable angina
0.835 0.165 0.000
I35.1 Aortic (valve) insufficiency
0.835 0.165 0.000
N60.1 Diffuse cystic mastopathy
0.834 0.166 0.000
N61 Inflammatory disorders of breast
0.833 0.167 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.828 0.172 0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.828 0.172 0.000
N87 Dysplasia of cervix uteri
0.827 0.173 0.000
S80-S89 Injuries to the knee and lower leg
0.826 0.174 0.000
K35-K38 Diseases of appendix
0.824 0.176 0.000
E86 Volume depletion
0.824 0.176 0.000
I21.9 Acute myocardial infarction, unspecified
0.824 0.176 0.000
K80.2 Calculus of gallbladder without cholecystitis
0.824 0.176 0.000
K50.1 Crohn's disease of large intestine
0.823 0.177 0.000
N60.0 Solitary cyst of breast
0.822 0.178 0.000
T81 Complications of procedures, not elsewhere classified
0.820 0.180 0.000
K82.4 Cholesterolosis of gallbladder
0.817 0.183 0.000
I35.0 Aortic (valve) stenosis
0.815 0.185 0.000
I20.8 Other forms of angina pectoris
0.813 0.187 0.000
N60.2 Fibroadenosis of breast
0.811 0.189 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.810 0.190 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.810 0.190 0.000
I25 Chronic ischaemic heart disease
0.809 0.191 0.000
N70-N77 Inflammatory diseases of female pelvic organs
0.809 0.191 0.000
I50.9 Heart failure, unspecified
0.808 0.192 0.000
N84 Polyp of female genital tract
0.808 0.192 0.000
G20-G26 Extrapyramidal and movement disorders
0.806 0.194 0.000
N25-N29 Other disorders of kidney and ureter
0.804 0.196 0.000
Chapter I Certain infectious and parasitic diseases
0.800 0.200 0.000
L82 Seborrhoeic keratosis
0.800 0.200 0.000
R07.2 Precordial pain
0.799 0.201 0.000
I51.8 Other ill-defined heart diseases
0.798 0.202 0.000
N89 Other noninflammatory disorders of vagina
0.798 0.202 0.000
R47-R49 Symptoms and signs involving speech and voice
0.793 0.207 0.000
E10 Insulin-dependent diabetes mellitus
0.792 0.208 0.000
R52 Pain, not elsewhere classified
0.792 0.208 0.000
N18.9 Chronic renal failure, unspecified
0.792 0.208 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.789 0.210 0.000
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.788 0.212 0.000
H10-H13 Disorders of conjunctiva
0.787 0.213 0.000
I44.1 Atrioventricular block, second degree
0.785 0.215 0.000
N60.3 Fibrosclerosis of breast
0.785 0.215 0.000
N88 Other noninflammatory disorders of cervix uteri
0.784 0.216 0.000
K82.8 Other specified diseases of gallbladder
0.784 0.216 0.000
L91 Hypertrophic disorders of skin
0.784 0.216 0.000
I60-I69 Cerebrovascular diseases
0.784 0.216 0.000
R59 Enlarged lymph nodes
0.783 0.217 0.000
H33 Retinal detachments and breaks
0.783 0.217 0.000
E11.3 With ophthalmic complications
0.783 0.217 0.000
N94.1 Dyspareunia
0.782 0.218 0.000
E73 Lactose intolerance
0.780 0.220 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.779 0.221 0.000
S50-S59 Injuries to the elbow and forearm
0.778 0.222 0.000
K75 Other inflammatory liver diseases
0.777 0.222 0.000
N81 Female genital prolapse
0.776 0.224 0.000
H35.8 Other specified retinal disorders
0.775 0.225 0.000
I42 Cardiomyopathy
0.775 0.225 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.773 0.227 0.000
E20-E35 Disorders of other endocrine glands
0.772 0.228 0.000
E87.7 Fluid overload
0.772 0.228 0.000
E87.6 Hypokalaemia
0.770 0.230 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.769 0.230 0.000
L72.9 Follicular cyst of skin and subcutaneous tissue, unspecified
0.766 0.234 0.000
N85 Other noninflammatory disorders of uterus, except cervix
0.766 0.234 0.000
K65-K67 Diseases of peritoneum
0.763 0.237 0.000
N18.4 Chronic kidney disease, stage 4
0.762 0.238 0.000
G93 Other disorders of brain
0.761 0.239 0.000
I22 Subsequent myocardial infarction
0.761 0.239 0.000
E11.4 With neurological complications
0.760 0.240 0.000
L72.8 Other follicular cysts of skin and subcutaneous tissue
0.760 0.240 0.000
B25-B34 Other viral diseases
0.758 0.242 0.000
S70-S79 Injuries to the hip and thigh
0.757 0.243 0.000
T81.8 Other complications of procedures, not elsewhere classified
0.757 0.243 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.756 0.244 0.000
H53-H54 Visual disturbances and blindness
0.756 0.244 0.000
I51.7 Cardiomegaly
0.756 0.244 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.754 0.246 0.000
K86 Other diseases of pancreas
0.752 0.247 0.000
L89 Decubitus ulcer
0.752 0.248 0.000
K83.8 Other specified diseases of biliary tract
0.752 0.248 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.751 0.249 0.000
S82 Fracture of lower leg, including ankle
0.751 0.249 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.749 0.250 0.000
I38 Endocarditis, valve unspecified
0.749 0.251 0.000
D52 Folate deficiency anaemia
0.749 0.251 0.000
Z75 Problems related to medical facilities and other health care
0.749 0.251 0.000
Chapter VIII Diseases of the ear and mastoid process
0.747 0.253 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.747 0.253 0.000
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified
0.746 0.253 0.000
R00.8 Other and unspecified abnormalities of heart beat
0.745 0.255 0.000
Z04 Examination and observation for other reasons
0.744 0.256 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.744 0.256 0.000
R01.1 Cardiac murmur, unspecified
0.741 0.259 0.000
K82.9 Disease of gallbladder, unspecified
0.740 0.260 0.000
L80 Vitiligo
0.740 0.260 0.000
Chapter XXII Codes for special purposes
0.740 0.260 0.000
N60.4 Mammary duct ectasia
0.740 0.260 0.000
Z02 Examination and encounter for administrative purposes
0.740 0.260 0.000
L50-L54 Urticaria and erythema
0.739 0.261 0.000
I35.9 Aortic valve disorder, unspecified
0.737 0.263 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.735 0.264 0.000
I44.0 Atrioventricular block, first degree
0.735 0.265 0.000
I65.2 Occlusion and stenosis of carotid artery
0.734 0.266 0.000
S66.3 Injury of extensor muscle and tendon of other finger at wrist and hand level
0.734 0.266 0.000
Q60-Q64 Congenital malformations of the urinary system
0.733 0.267 0.000
L60 Nail disorders
0.732 0.267 0.000
E16 Other disorders of pancreatic internal secretion
0.732 0.268 0.000
R59.9 Enlarged lymph nodes, unspecified
0.731 0.268 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.731 0.269 0.000
R05 Cough
0.731 0.269 0.000
I46 Cardiac arrest
0.730 0.270 0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants
0.730 0.270 0.000
Z72 Problems related to lifestyle
0.730 0.270 0.000
N81.2 Incomplete uterovaginal prolapse
0.730 0.270 0.000
I51.9 Heart disease, unspecified
0.729 0.271 0.000
N90.9 Noninflammatory disorder of vulva and perineum, unspecified
0.729 0.271 0.000
N87.0 Mild cervical dysplasia
0.728 0.272 0.000
B34 Viral infection of unspecified site
0.728 0.272 0.000
L72.0 Epidermal cyst
0.726 0.274 0.000
T81.4 Infection following a procedure, not elsewhere classified
0.726 0.274 0.000
D69 Purpura and other haemorrhagic conditions
0.725 0.275 0.000
Chapter V Mental and behavioural disorders
0.725 0.275 0.000
K85.1 Biliary acute pancreatitis
0.722 0.278 0.000
I25.1 Atherosclerotic heart disease
0.722 0.278 0.000
H35.3 Degeneration of macula and posterior pole
0.722 0.278 0.000
N00-N08 Glomerular diseases
0.721 0.279 0.000
K51.9 Ulcerative colitis, unspecified
0.720 0.280 0.000
K90 Intestinal malabsorption
0.720 0.280 0.000
Chapter XX External causes of morbidity and mortality
0.720 0.280 0.000
Z71 Persons encountering health services for other counselling and medical advice, not elsewhere classified
0.718 0.282 0.000
N13 Obstructive and reflux uropathy
0.718 0.282 0.000
K51.2 Ulcerative (chronic) proctitis
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
E40-E46 Malnutrition
0.717 0.283 0.000
K87 Disorders of gallbladder, biliary tract and pancreas in diseases classified elsewhere
0.717 0.283 0.000
K74.3 Primary biliary cirrhosis
0.717 0.283 0.000
H43-H45 Disorders of vitreous body and globe
0.716 0.284 0.000
I00-I02 Acute rheumatic fever
0.716 0.284 0.000
E85 Amyloidosis
0.716 0.284 0.000
E84 Cystic fibrosis
0.716 0.284 0.000
E79 Disorders of purine and pyrimidine metabolism
0.716 0.284 0.000
E77 Disorders of glycoprotein metabolism
0.716 0.284 0.000
E76 Disorders of glycosaminoglycan metabolism
0.716 0.284 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.716 0.284 0.000
E74 Other disorders of carbohydrate metabolism
0.716 0.284 0.000
E72 Other disorders of amino-acid metabolism
0.716 0.284 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.716 0.284 0.000
E70 Disorders of aromatic amino-acid metabolism
0.716 0.284 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.716 0.284 0.000
N98 Complications associated with artificial fertilisation
0.716 0.284 0.000
N91 Absent, scanty and rare menstruation
0.716 0.284 0.000
N82 Fistulae involving female genital tract
0.716 0.284 0.000
N96 Habitual aborter
0.716 0.284 0.000
S40-S49 Injuries to the shoulder and upper arm
0.715 0.284 0.000
N95 Menopausal and other perimenopausal disorders
0.715 0.285 0.000
I52 Other heart disorders in diseases classified elsewhere
0.715 0.285 0.000
I48 Atrial fibrillation and flutter
0.715 0.285 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.715 0.285 0.000
I41 Myocarditis in diseases classified elsewhere
0.715 0.285 0.000
I40 Acute myocarditis
0.715 0.285 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.715 0.285 0.000
I37 Pulmonary valve disorders
0.715 0.285 0.000
I36 Nonrheumatic tricuspid valve disorders
0.715 0.285 0.000
I32 Pericarditis in diseases classified elsewhere
0.715 0.285 0.000
I30 Acute pericarditis
0.715 0.285 0.000
T33-T35 Frostbite
0.715 0.285 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.715 0.285 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.715 0.285 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.715 0.285 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.715 0.285 0.000
T00-T07 Injuries involving multiple body regions
0.715 0.285 0.000
S10-S19 Injuries to the neck
0.715 0.285 0.000
E78.9 Disorder of lipoprotein metabolism, unspecified
0.715 0.285 0.000
E78.8 Other disorders of lipoprotein metabolism
0.715 0.285 0.000
E78.6 Lipoprotein deficiency
0.715 0.285 0.000
E78.4 Other hyperlipidaemia
0.715 0.285 0.000
E78.3 Hyperchylomicronaemia
0.715 0.285 0.000
E78.2 Mixed hyperlipidaemia
0.715 0.285 0.000
E78.1 Pure hyperglyceridaemia
0.715 0.285 0.000
L10-L14 Bullous disorders
0.714 0.286 0.000
T79-T79 Certain early complications of trauma
0.714 0.286 0.000
R52.1 Chronic intractable pain
0.714 0.286 0.000
D55-D59 Haemolytic anaemias
0.713 0.287 0.000
L75 Apocrine sweat disorders
0.711 0.288 0.000
L74 Eccrine sweat disorders
0.711 0.288 0.000
L73 Other follicular disorders
0.711 0.288 0.000
L70 Acne
0.711 0.288 0.000
L68 Hypertrichosis
0.711 0.288 0.000
L67 Hair colour and hair shaft abnormalities
0.711 0.288 0.000
L66 Cicatricial alopecia [scarring hair loss]
0.711 0.288 0.000
L65 Other nonscarring hair loss
0.711 0.288 0.000
L64 Androgenic alopecia
0.711 0.288 0.000
L63 Alopecia areata
0.711 0.288 0.000
L62 Nail disorders in diseases classified elsewhere
0.711 0.288 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.711 0.289 0.000
Z40-Z54 Persons encountering health services for specific procedures and health care
0.711 0.289 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.711 0.289 0.000
I24 Other acute ischaemic heart diseases
0.711 0.289 0.000
R79 Other abnormal findings of blood chemistry
0.710 0.290 0.000
L72.2 Steatocystoma multiplex
0.710 0.290 0.000
I50.1 Left ventricular failure
0.709 0.291 0.000
T87 Complications peculiar to reattachment and amputation
0.709 0.291 0.000
T86 Failure and rejection of transplanted organs and tissues
0.709 0.291 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.709 0.291 0.000
D53 Other nutritional anaemias
0.709 0.291 0.000
N75 Diseases of Bartholin's gland
0.709 0.291 0.000
K83.0 Cholangitis
0.708 0.292 0.000
K80.3 Calculus of bile duct with cholangitis
0.707 0.293 0.000
K80.8 Other cholelithiasis
0.707 0.293 0.000
D51.8 Other vitamin B12 deficiency anaemias
0.707 0.293 0.000
D51.3 Other dietary vitamin B12 deficiency anaemia
0.707 0.293 0.000
D51.2 Transcobalamin II deficiency
0.707 0.293 0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.707 0.293 0.000
B34.9 Viral infection, unspecified
0.707 0.293 0.000
G70-G73 Diseases of myoneural junction and muscle
0.707 0.293 0.000
L71 Rosacea
0.706 0.293 0.000
K50.0 Crohn's disease of small intestine
0.706 0.294 0.000
E13 Other specified diabetes mellitus
0.706 0.294 0.000
E12 Malnutrition-related diabetes mellitus
0.706 0.294 0.000
I23 Certain current complications following acute myocardial infarction
0.706 0.294 0.000
K91.8 Other postprocedural disorders of digestive system, not elsewhere classified
0.705 0.295 0.000
R57 Shock, not elsewhere classified
0.705 0.295 0.000
S92 Fracture of foot, except ankle
0.705 0.295 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.704 0.295 0.000
I45 Other conduction disorders
0.704 0.296 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.703 0.297 0.000
N64 Other disorders of breast
0.701 0.299 0.000
D80-D89 Certain disorders involving the immune mechanism
0.700 0.300 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.700 0.300 0.000
E50-E64 Other nutritional deficiencies
0.699 0.301 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.699 0.301 0.000
E11.8 With unspecified complications
0.697 0.303 0.000
E11.7 With multiple complications
0.697 0.303 0.000
E11.6 With other specified complications
0.697 0.303 0.000
E11.2 With renal complications
0.697 0.303 0.000
E11.1 With ketoacidosis
0.697 0.303 0.000
E11.0 With coma
0.697 0.303 0.000
K51.8 Other ulcerative colitis
0.697 0.303 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.697 0.303 0.000
I05-I09 Chronic rheumatic heart diseases
0.695 0.305 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.695 0.305 0.000
N18.5 Chronic kidney disease, stage 5
0.694 0.306 0.000
R80 Isolated proteinuria
0.693 0.307 0.000
N90.5 Atrophy of vulva
0.692 0.308 0.000
S91 Open wound of ankle and foot
0.691 0.309 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.690 0.310 0.000
I49 Other cardiac arrhythmias
0.690 0.310 0.000
K35 Acute appendicitis
0.690 0.310 0.000
N88.2 Stricture and stenosis of cervix uteri
0.688 0.312 0.000
K83.9 Disease of biliary tract, unspecified
0.688 0.312 0.000
K83.5 Biliary cyst
0.688 0.312 0.000
K83.4 Spasm of sphincter of Oddi
0.688 0.312 0.000
K83.3 Fistula of bile duct
0.688 0.312 0.000
K83.2 Perforation of bile duct
0.688 0.312 0.000
N60.9 Benign mammary dysplasia, unspecified
0.688 0.312 0.000
S66.1 Injury of flexor muscle and tendon of other finger at wrist and hand level
0.688 0.312 0.000
H55-H59 Other disorders of eye and adnexa
0.687 0.313 0.000
D68 Other coagulation defects
0.687 0.313 0.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.686 0.314 0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.686 0.314 0.000
K74.0 Hepatic fibrosis
0.686 0.314 0.000
S90 Superficial injury of ankle and foot
0.685 0.315 0.000
S82.8 Fractures of other parts of lower leg
0.685 0.315 0.000
K80.4 Calculus of bile duct with cholecystitis
0.685 0.315 0.000
Z45 Adjustment and management of implanted device
0.685 0.315 0.000
S20-S29 Injuries to the thorax
0.684 0.315 0.000
R07.4 Chest pain, unspecified
0.684 0.316 0.000
N84.1 Polyp of cervix uteri
0.684 0.316 0.000
G25 Other extrapyramidal and movement disorders
0.683 0.317 0.000
K76 Other diseases of liver
0.682 0.317 0.000
E65-E68 Obesity and other hyperalimentation
0.682 0.318 0.000
K72 Hepatic failure, not elsewhere classified
0.682 0.318 0.000
I35.8 Other aortic valve disorders
0.681 0.319 0.000
T66-T78 Other and unspecified effects of external causes
0.680 0.319 0.000
T85.4 Mechanical complication of breast prosthesis and implant
0.680 0.320 0.000
G95 Other diseases of spinal cord
0.679 0.321 0.000
E88 Other metabolic disorders
0.679 0.321 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.677 0.323 0.000
I33 Acute and subacute endocarditis
0.677 0.323 0.000
N99-N99 Other disorders of the genitourinary system
0.677 0.323 0.000
Z01 Other special examinations and investigations of persons without complaint or reported diagnosis
0.676 0.324 0.000
L98 Other disorders of skin and subcutaneous tissue, not elsewhere classified
0.676 0.324 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.675 0.324 0.000
N92.5 Other specified irregular menstruation
0.674 0.325 0.000
N92.4 Excessive bleeding in the premenopausal period
0.674 0.325 0.000
N92.2 Excessive menstruation at puberty
0.674 0.325 0.000
K50.8 Other Crohn's disease
0.674 0.326 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.674 0.326 0.000
N26 Unspecified contracted kidney
0.674 0.326 0.000
N12 Tubulo-interstitial nephritis, not specified as acute or chronic
0.673 0.327 0.000
L81 Other disorders of pigmentation
0.671 0.329 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.671 0.329 0.000
N94.5 Secondary dysmenorrhoea
0.671 0.329 0.000
N94.4 Primary dysmenorrhoea
0.671 0.329 0.000
N94.3 Premenstrual tension syndrome
0.671 0.329 0.000
N94.2 Vaginismus
0.671 0.329 0.000
N94.0 Mittelschmerz
0.671 0.329 0.000
I20.9 Angina pectoris, unspecified
0.671 0.329 0.000
I44.6 Other and unspecified fascicular block
0.671 0.329 0.000
I44.5 Left posterior fascicular block
0.671 0.329 0.000
I44.4 Left anterior fascicular block
0.671 0.329 0.000
I44.3 Other and unspecified atrioventricular block
0.671 0.329 0.000
G20 Parkinson's disease
0.671 0.329 0.000
I20.1 Angina pectoris with documented spasm
0.670 0.330 0.000
K82.3 Fistula of gallbladder
0.669 0.331 0.000
K82.2 Perforation of gallbladder
0.669 0.331 0.000
K82.1 Hydrops of gallbladder
0.669 0.331 0.000
K82.0 Obstruction of gallbladder
0.669 0.331 0.000
N17 Acute renal failure
0.668 0.332 0.000
N10 Acute tubulo-interstitial nephritis
0.667 0.333 0.000
G93.1 Anoxic brain damage, not elsewhere classified
0.667 0.333 0.000
N89.8 Other specified noninflammatory disorders of vagina
0.667 0.333 0.000
N94.9 Unspecified condition associated with female genital organs and menstrual cycle
0.667 0.333 0.000
S82.6 Fracture of lateral malleolus
0.667 0.333 0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]
0.666 0.333 0.000
Z02.8 Other examinations for administrative purposes
0.666 0.334 0.000
N60.8 Other benign mammary dysplasias
0.666 0.334 0.000
R55 Syncope and collapse
0.666 0.334 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.665 0.335 0.000
Z75.1 Person awaiting admission to adequate facility elsewhere
0.665 0.335 0.000
H11 Other disorders of conjunctiva
0.664 0.336 0.000
K74.6 Other and unspecified cirrhosis of liver
0.663 0.336 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.663 0.337 0.000
S62 Fracture at wrist and hand level
0.663 0.337 0.000
Z45.2 Adjustment and management of vascular access device
0.662 0.338 0.000
Z73 Problems related to life-management difficulty
0.661 0.339 0.000
K77 Liver disorders in diseases classified elsewhere
0.661 0.339 0.000
K73 Chronic hepatitis, not elsewhere classified
0.661 0.339 0.000
K71 Toxic liver disease
0.661 0.339 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.661 0.339 0.000
I51.6 Cardiovascular disease, unspecified
0.659 0.341 0.000
I51.5 Myocardial degeneration
0.659 0.341 0.000
I51.4 Myocarditis, unspecified
0.659 0.341 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.659 0.341 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.659 0.341 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.659 0.341 0.000
I51.0 Cardiac septal defect, acquired
0.659 0.341 0.000
K85.9 Acute pancreatitis, unspecified
0.659 0.341 0.000
L92 Granulomatous disorders of skin and subcutaneous tissue
0.659 0.341 0.000
S69 Other and unspecified injuries of wrist and hand
0.659 0.341 0.000
H35.0 Background retinopathy and retinal vascular changes
0.659 0.341 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.659 0.341 0.000
T85.9 Unspecified complication of internal prosthetic device, implant and graft
0.658 0.342 0.000
T85.3 Mechanical complication of other ocular prosthetic devices, imnplants and grafts
0.658 0.342 0.000
T85.2 Mechanical complication of intraocular lens
0.658 0.342 0.000
T85.1 Mechanical complication of implanted electronic stimulator of nervous system
0.658 0.342 0.000
T85.0 Mechanical complication of ventricular intracranial (communicating) shunt
0.658 0.342 0.000
L91.8 Other hypertrophic disorders of skin
0.657 0.343 0.000
N90.8 Other specified noninflammatory disorders of vulva and perineum
0.656 0.344 0.000
H33.0 Retinal detachment with retinal break
0.656 0.344 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.655 0.344 0.000
S67 Crushing injury of wrist and hand
0.655 0.345 0.000
Z72.0 Tobacco use
0.654 0.346 0.000
E87.2 Acidosis
0.653 0.347 0.000
T83.1 Mechanical complication of other urinary devices and implants
0.652 0.348 0.000
E16.2 Hypoglycaemia, unspecified
0.652 0.348 0.000
T88.7 Unspecified adverse effect of drug or medicament
0.651 0.349 0.000
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere
0.651 0.349 0.000
L95 Vasculitis limited to skin, not elsewhere classified
0.651 0.349 0.000
L94 Other localised connective tissue disorders
0.651 0.349 0.000
L93 Lupus erythematosus
0.651 0.349 0.000
L87 Transepidermal elimination disorders
0.651 0.349 0.000
L88 Pyoderma gangrenosum
0.651 0.349 0.000
L86 Keratoderma in diseases classified elsewhere
0.651 0.349 0.000
L83 Acanthosis nigricans
0.651 0.349 0.000
T85.5 Mechanical complication of gastro-intestinal prosthetic devices, implants and grafts
0.650 0.350 0.000
H35.9 Retinal disorder, unspecified
0.650 0.350 0.000
B35-B49 Mycoses
0.649 0.351 0.000
E10.1 With ketoacidosis
0.648 0.352 0.000
Q00-Q07 Congenital malformations of the nervous system
0.647 0.353 0.000
Z43 Attention to artificial openings
0.647 0.353 0.000
K91.4 Colostomy and enterostomy malfunction
0.646 0.354 0.000
Z71.8 Other specified counselling
0.646 0.354 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.645 0.354 0.000
K80.5 Calculus of bile duct without cholangitis or cholecystitis
0.645 0.355 0.000
Z11 Special screening examination for infectious and parasitic diseases
0.645 0.355 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.645 0.355 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.645 0.355 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.645 0.355 0.000
E87.4 Mixed disorder of acid-base balance
0.645 0.355 0.000
E87.3 Alkalosis
0.645 0.355 0.000
E87.0 Hyperosmolality and hypernatraemia
0.644 0.356 0.000
N75.0 Cyst of Bartholin's gland
0.644 0.356 0.000
N85.9 Noninflammatory disorder of uterus, unspecified
0.644 0.356 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.644 0.356 0.000
H31 Other disorders of choroid
0.644 0.356 0.000
H30 Chorioretinal inflammation
0.644 0.356 0.000
L40-L45 Papulosquamous disorders
0.644 0.356 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.643 0.357 0.000
N81.9 Female genital prolapse, unspecified
0.643 0.357 0.000
S89 Other and unspecified injuries of lower leg
0.642 0.358 0.000
S65 Injury of blood vessels at wrist and hand level
0.640 0.360 0.000
N18.8 Other chronic renal failure
0.639 0.360 0.000
N18.1 Chronic kidney disease, stage 1
0.639 0.360 0.000
S66.2 Injury of extensor muscle and tendon of thumb at wrist and hand level
0.639 0.361 0.000
I34 Nonrheumatic mitral valve disorders
0.639 0.361 0.000
S82.80 Fractures of other parts of lower leg (closed)
0.638 0.362 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.638 0.362 0.000
Z12 Special screening examination for neoplasms
0.638 0.362 0.000
N18.2 Chronic kidney disease, stage 2
0.638 0.362 0.000
H33.2 Serous retinal detachment
0.637 0.363 0.000
L84 Corns and callosities
0.636 0.363 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.635 0.365 0.000
K51.3 Ulcerative (chronic) rectosigmoiditis
0.634 0.365 0.000
E10.2 With renal complications
0.634 0.366 0.000
Z13 Special screening examination for other diseases and disorders
0.634 0.366 0.000
G91 Hydrocephalus
0.634 0.366 0.000
Z04.8 Examination and observation for other specified reasons
0.634 0.366 0.000
R49 Voice disturbances
0.634 0.366 0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]
0.633 0.367 0.000
R62 Lack of expected normal physiological development
0.633 0.367 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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