TreeWAS – Variant ID: rs78488377

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
I25 Chronic ischaemic heart disease	1.000	0.000	0.000
I25.9 Chronic ischaemic heart disease, unspecified	0.999	0.001	0.000
I25.8 Other forms of chronic ischaemic heart disease	0.998	0.002	0.000
I25.1 Atherosclerotic heart disease	0.998	0.002	0.000
I20-I25 Ischaemic heart diseases	0.997	0.003	0.000
I25.2 Old myocardial infarction	0.994	0.006	0.000
I20 Angina pectoris	0.993	0.007	0.000
I20.9 Angina pectoris, unspecified	0.981	0.019	0.000
I20.0 Unstable angina	0.943	0.057	0.000
I21 Acute myocardial infarction	0.897	0.103	0.000
I24 Other acute ischaemic heart diseases	0.813	0.187	0.000
I25.5 Ischaemic cardiomyopathy	0.797	0.203	0.000
I23 Certain current complications following acute myocardial infarction	0.787	0.213	0.000
I21.4 Acute subendocardial myocardial infarction	0.786	0.214	0.000
I21.3 Acute transmural myocardial infarction of unspecified site	0.769	0.231	0.000
I25.0 Atherosclerotic cardiovascular disease, so described	0.755	0.245	0.000
I25.4 Coronary artery aneurysm	0.740	0.260	0.000
I25.6 Silent myocardial ischaemia	0.717	0.283	0.000
I21.1 Acute transmural myocardial infarction of inferior wall	0.701	0.299	0.000
I21.9 Acute myocardial infarction, unspecified	0.694	0.306	0.000
I24.9 Acute ischaemic heart disease, unspecified	0.657	0.343	0.000
I20.1 Angina pectoris with documented spasm	0.657	0.343	0.000
I20.8 Other forms of angina pectoris	0.651	0.349	0.000
I21.X Presumed acute myicardial infaction (unconfirmed)	0.643	0.356	0.000
I23.8 Other current complications following acute myocardial infarction	0.636	0.364	0.000
I22 Subsequent myocardial infarction	0.620	0.379	0.000
I24.8 Other forms of acute ischaemic heart disease	0.603	0.397	0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.600	0.400	0.000
I21.0 Acute transmural myocardial infarction of anterior wall	0.592	0.408	0.000
I24.1 Dressler's syndrome	0.583	0.417	0.000
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction	0.564	0.436	0.000
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction	0.564	0.436	0.000
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction	0.564	0.436	0.000
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction	0.564	0.436	0.000
I23.2 Ventricular septal defect as current complication following acute myocardial infarction	0.564	0.436	0.000
I23.1 Atrial septal defect as current complication following acute myocardial infarction	0.564	0.436	0.000
I23.0 Haemopericardium as current complication following acute myocardial infarction	0.564	0.436	0.000
I25.3 Aneurysm of heart	0.553	0.447	0.000
I22.0 Subsequent myocardial infarction of anterior wall	0.498	0.502	0.000
I21.2 Acute transmural myocardial infarction of other sites	0.468	0.532	0.000
M18 Arthrosis of first carpometacarpal joint	0.001	0.559	0.440
M18.9 Arthrosis of first carpometacarpal joint, unspecified	0.000	0.559	0.441
M15-M19 Arthrosis	0.003	0.562	0.436
M19 Other arthrosis	0.000	0.567	0.433
M17 Gonarthrosis [arthrosis of knee]	0.001	0.577	0.423
Chapter IX Diseases of the circulatory system	0.422	0.578	0.000
M17.9 Gonarthrosis, unspecified	0.000	0.580	0.420
I22.8 Subsequent myocardial infarction of other sites	0.419	0.580	0.000
M19.9 Arthrosis, unspecified	0.000	0.582	0.418
M19.94 Arthrosis, unspecified (Hand)	0.000	0.604	0.396
M18.1 Other primary arthrosis of first carpometacarpal joint	0.000	0.609	0.391
I22.9 Subsequent myocardial infarction of unspecified site	0.382	0.618	0.000
M19.0 Primary arthrosis of other joints	0.000	0.620	0.380
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.378	0.622	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.376	0.624	0.000
I22.1 Subsequent myocardial infarction of inferior wall	0.372	0.628	0.000
E89.0 Postprocedural hypothyroidism	0.369	0.631	0.000
H83.0 Labyrinthitis	0.367	0.633	0.000
E70-E90 Metabolic disorders	0.367	0.633	0.000
Chapter XV Pregnancy, childbirth and the puerperium	0.366	0.634	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.366	0.634	0.000
Z95.5 Presence of coronary angioplasty implant and graft	0.364	0.636	0.000
M19.1 Posttraumatic arthrosis of other joints	0.000	0.638	0.362
H83 Other diseases of inner ear	0.360	0.640	0.000
I80 Phlebitis and thrombophlebitis	0.360	0.640	0.000
E87 Other disorders of fluid, electrolyte and acid-base balance	0.359	0.641	0.000
E87.5 Hyperkalaemia	0.358	0.642	0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.357	0.643	0.000
# Top node	0.356	0.644	0.000
H80-H83 Diseases of inner ear	0.355	0.645	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.353	0.647	0.000
Chapter VIII Diseases of the ear and mastoid process	0.353	0.647	0.000
I26 Pulmonary embolism	0.346	0.654	0.000
Z95 Presence of cardiac and vascular implants and grafts	0.345	0.655	0.000
M17.1 Other primary gonarthrosis	0.000	0.655	0.345
Z95.1 Presence of aortocoronary bypass graft	0.344	0.656	0.000
O94-O99 Other obstetric conditions, not elsewhere classified	0.344	0.656	0.000
M19.01 Primary arthrosis of other joints (Shoulder region)	0.000	0.657	0.343
I85 Oesophageal varices	0.342	0.658	0.000
I95-I99 Other and unspecified disorders of the circulatory system	0.340	0.660	0.000
M19.91 Arthrosis, unspecified (Shoulder region)	0.000	0.662	0.338
M19.93 Arthrosis, unspecified (Forearm)	0.000	0.664	0.336
O00-O08 Pregnancy with abortive outcome	0.336	0.664	0.000
M19.96 Arthrosis, unspecified-Lower leg	0.000	0.670	0.330
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.328	0.672	0.000
M19.95 Arthrosis, unspecified (Pelvic region and thigh)	0.000	0.673	0.327
I80.8 Phlebitis and thrombophlebitis of other sites	0.326	0.674	0.000
O14 Gestational [pregnancy-induced] hypertension with significant proteinuria	0.326	0.674	0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria	0.325	0.675	0.000
Chapter VI Diseases of the nervous system	0.324	0.676	0.000
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities	0.324	0.676	0.000
M17.3 Other posttraumatic gonarthrosis	0.000	0.677	0.323
I26.9 Pulmonary embolism without mention of acute cor pulmonale	0.319	0.681	0.000
I82 Other venous embolism and thrombosis	0.317	0.683	0.000
M18.5 Other secondary arthrosis of first carpometacarpal joint	0.001	0.684	0.316
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral	0.001	0.684	0.316
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint	0.001	0.684	0.316
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral	0.001	0.684	0.316
M19.92 Arthrosis, unspecified (Upper arm)	0.000	0.685	0.314
M15 Polyarthrosis	0.002	0.685	0.312
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral	0.001	0.687	0.312
M19.99 Arthrosis, unspecified (Site unspecified)	0.000	0.688	0.312
I98 Other disorders of circulatory system in diseases classified elsewhere	0.312	0.688	0.000
M19.17 Post-traumatic arthrosis of other joints (Ankle and foot)	0.000	0.689	0.311
I85.9 Oesophageal varices without bleeding	0.311	0.689	0.000
M19.8 Other specified arthrosis	0.000	0.689	0.310
M19.2 Other secondary arthrosis	0.000	0.689	0.310
E87.3 Alkalosis	0.310	0.690	0.000
I81 Portal vein thrombosis	0.309	0.691	0.000
M19.04 Primary arthrosis of other joints (Hand)	0.000	0.692	0.308
O99.8 Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium	0.308	0.692	0.000
M19.98 Arthrosis, unspecified (Other)	0.000	0.695	0.305
M17.4 Other secondary gonarthrosis, bilateral	0.001	0.696	0.303
M17.2 Posttraumatic gonarthrosis, bilateral	0.001	0.696	0.303
I80.3 Phlebitis and thrombophlebitis of lower extremities, unspecified	0.303	0.697	0.000
I00-I02 Acute rheumatic fever	0.302	0.697	0.000
E85 Amyloidosis	0.302	0.698	0.000
G40-G47 Episodic and paroxysmal disorders	0.301	0.699	0.000
I28 Other diseases of pulmonary vessels	0.301	0.699	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.300	0.700	0.000
O02 Other abnormal products of conception	0.300	0.700	0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.298	0.702	0.000
O03 Spontaneous abortion	0.297	0.703	0.000
E87.7 Fluid overload	0.294	0.706	0.000
O14.9 Preeclampsia, unspecified	0.289	0.711	0.000
O85-O92 Complications predominantly related to the puerperium	0.288	0.712	0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.287	0.713	0.000
G44 Other headache syndromes	0.286	0.714	0.000
H60-H62 Diseases of external ear	0.285	0.715	0.000
E10-E14 Diabetes mellitus	0.285	0.715	0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified	0.284	0.716	0.000
Z95.4 Presence of other heart-valve replacement	0.283	0.717	0.000
Z95.3 Presence of xenogenic heart valve	0.282	0.718	0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.282	0.718	0.000
M19.90 Arthrosis, unspecified (Multiple sites)	0.000	0.719	0.281
I98.2 Oesophageal varices in diseases classified elsewhere	0.281	0.719	0.000
E74 Other disorders of carbohydrate metabolism	0.280	0.720	0.000
M19.09 Primary arthrosis of other joints (Site unspecified)	0.000	0.720	0.280
G45 Transient cerebral ischaemic attacks and related syndromes	0.278	0.722	0.000
O16 Unspecified maternal hypertension	0.277	0.723	0.000
Z95.0 Presence of cardiac pacemaker	0.277	0.723	0.000
E89.2 Postprocedural hypoparathyroidism	0.276	0.724	0.000
G44.2 Tension-type headache	0.275	0.725	0.000
O02.1 Missed abortion	0.275	0.725	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.275	0.725	0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts	0.274	0.726	0.000
E00-E07 Disorders of thyroid gland	0.274	0.726	0.000
G00-G09 Inflammatory diseases of the central nervous system	0.274	0.726	0.000
M19.08 Primary arthrosis of other joints (Other)	0.000	0.727	0.273
M19.06 Primary arthrosis of other joints-Lower leg	0.000	0.727	0.273
M19.05 Primary arthrosis of other joints (Pelvic region and thigh)	0.000	0.727	0.273
M19.03 Primary arthrosis of other joints (Forearm)	0.000	0.727	0.273
M19.00 Primary arthrosis of other joints (Multiple sites)	0.000	0.727	0.273
M17.5 Other secondary gonarthrosis	0.001	0.728	0.272
O80-O84 Delivery	0.271	0.729	0.000
I88 Nonspecific lymphadenitis	0.271	0.729	0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified	0.270	0.730	0.000
I26.0 Pulmonary embolism with mention of acute cor pulmonale	0.270	0.730	0.000
S40-S49 Injuries to the shoulder and upper arm	0.270	0.730	0.000
S70-S79 Injuries to the hip and thigh	0.269	0.731	0.000
O03.4 Incomplete, without complication	0.267	0.733	0.000
T20-T25 Burns and corrosions of external body surface, specified by site	0.267	0.733	0.000
H80 Otosclerosis	0.266	0.733	0.000
Chapter V Mental and behavioural disorders	0.266	0.734	0.000
O14.0 Moderate preeclampsia	0.265	0.735	0.000
T85 Complications of other internal prosthetic devices, implants and grafts	0.264	0.736	0.000
I86 Varicose veins of other sites	0.264	0.736	0.000
I85.0 Oesophageal varices with bleeding	0.264	0.736	0.000
E80 Disorders of porphyrin and bilirubin metabolism	0.264	0.736	0.000
E84 Cystic fibrosis	0.263	0.737	0.000
E79 Disorders of purine and pyrimidine metabolism	0.263	0.737	0.000
E77 Disorders of glycoprotein metabolism	0.263	0.737	0.000
E76 Disorders of glycosaminoglycan metabolism	0.263	0.737	0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.263	0.737	0.000
E72 Other disorders of amino-acid metabolism	0.263	0.737	0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.263	0.737	0.000
E70 Disorders of aromatic amino-acid metabolism	0.263	0.737	0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.263	0.737	0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.263	0.737	0.000
E89.8 Other postprocedural endocrine and metabolic disorders	0.263	0.737	0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.263	0.737	0.000
E89.5 Postprocedural testicular hypofunction	0.263	0.737	0.000
E89.4 Postprocedural ovarian failure	0.263	0.737	0.000
E89.1 Postprocedural hypoinsulinaemia	0.263	0.737	0.000
O99.2 Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium	0.263	0.737	0.000
G90-G99 Other disorders of the nervous system	0.261	0.739	0.000
G45.4 Transient global amnesia	0.260	0.740	0.000
O99.0 Anaemia complicating pregnancy, childbirth and the puerperium	0.260	0.740	0.000
M19.19 Post-traumatic arthrosis of other joints (Site unspecified)	0.000	0.740	0.259
M19.18 Post-traumatic arthrosis of other joints (Other)	0.000	0.740	0.259
M19.16 Post-traumatic arthrosis of other joints-Lower leg	0.000	0.740	0.259
M19.15 Post-traumatic arthrosis of other joints (Pelvic region and thigh)	0.000	0.740	0.259
M19.14 Post-traumatic arthrosis of other joints (Hand)	0.000	0.740	0.259
M19.13 Post-traumatic arthrosis of other joints (Forearm)	0.000	0.740	0.259
M19.12 Post-traumatic arthrosis of other joints (Upper arm)	0.000	0.740	0.259
M19.11 Post-traumatic arthrosis of other joints (Shoulder region)	0.000	0.740	0.259
M19.10 Post-traumatic arthrosis of other joints (Multiple sites)	0.000	0.740	0.259
E86 Volume depletion	0.260	0.740	0.000
H83.9 Disease of inner ear, unspecified	0.258	0.742	0.000
H83.8 Other specified diseases of inner ear	0.258	0.742	0.000
H83.3 Noise effects on inner ear	0.258	0.742	0.000
H83.2 Labyrinthine dysfunction	0.258	0.742	0.000
H83.1 Labyrinthine fistula	0.258	0.742	0.000
E87.4 Mixed disorder of acid-base balance	0.258	0.742	0.000
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere	0.257	0.743	0.000
O15 Eclampsia	0.256	0.744	0.000
O12 Gestational [pregnancy-induced] oedema and proteinuria without hypertension	0.256	0.744	0.000
O10 Pre-existing hypertension complicating pregnancy, childbirth and the puerperium	0.256	0.744	0.000
O11 Pre-existing hypertensive disorder with superimposed proteinuria	0.256	0.744	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.255	0.745	0.000
H82 Vertiginous syndromes in diseases classified elsewhere	0.255	0.745	0.000
I82.9 Embolism and thrombosis of unspecified vein	0.254	0.746	0.000
I82.8 Embolism and thrombosis of other specified veins	0.254	0.746	0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts	0.254	0.746	0.000
O48 Prolonged pregnancy	0.252	0.748	0.000
O36 Maternal care for other known or suspected foetal problems	0.252	0.748	0.000
H81 Disorders of vestibular function	0.251	0.749	0.000
I05-I09 Chronic rheumatic heart diseases	0.250	0.750	0.001
E73 Lactose intolerance	0.250	0.750	0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.250	0.750	0.000
M19.02 Primary arthrosis of other joints (Upper arm)	0.000	0.751	0.249
F30-F39 Mood [affective] disorders	0.248	0.752	0.000
G61 Inflammatory polyneuropathy	0.247	0.753	0.000
E85.3 Secondary systemic amyloidosis	0.247	0.753	0.000
I80.9 Phlebitis and thrombophlebitis of unspecified site	0.247	0.753	0.000
S50-S59 Injuries to the elbow and forearm	0.247	0.753	0.000
E87.0 Hyperosmolality and hypernatraemia	0.247	0.753	0.000
I28.8 Other specified diseases of pulmonary vessels	0.247	0.753	0.000
E88 Other metabolic disorders	0.247	0.753	0.000
O98 Maternal infectious and parasitic diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.246	0.753	0.000
O97 Death from sequelae of direct obstetric causes	0.246	0.753	0.000
O96 Death from any obstetric cause occurring more than 42 days but less than one year after delivery	0.246	0.753	0.000
O95 Obstetric death of unspecified cause	0.246	0.753	0.000
O94 Sequelae of complication of pregnancy, childbirth and the puerperium	0.246	0.753	0.000
O34 Maternal care for known or suspected abnormality of pelvic organs	0.246	0.754	0.000
G35-G37 Demyelinating diseases of the central nervous system	0.246	0.754	0.000
S10-S19 Injuries to the neck	0.246	0.754	0.000
Chapter XXII Codes for special purposes	0.245	0.755	0.000
I97.1 Other functional disturbances following cardiac surgery	0.245	0.755	0.000
T85.3 Mechanical complication of other ocular prosthetic devices, imnplants and grafts	0.243	0.757	0.000
O99.3 Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium	0.242	0.757	0.000
O14.1 Severe preeclampsia	0.242	0.758	0.000
G63 Polyneuropathy in diseases classified elsewhere	0.242	0.758	0.000
E89.3 Postprocedural hypopituitarism	0.241	0.759	0.000
O08 Complications following abortion and ectopic and molar pregnancy	0.241	0.759	0.000
O07 Failed attempted abortion	0.241	0.759	0.000
O06 Unspecified abortion	0.241	0.759	0.000
O05 Other abortion	0.241	0.759	0.000
O01 Hydatidiform mole	0.241	0.759	0.000
O35 Maternal care for known or suspected foetal abnormality and damage	0.240	0.760	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.237	0.763	0.000
M19.07 Primary arthrosis of other joints (Ankle and foot)	0.000	0.763	0.236
O00 Ectopic pregnancy	0.236	0.764	0.000
T88 Other complications of surgical and medical care, not elsewhere classified	0.235	0.765	0.000
O99.7 Diseases of the skin and subcutaneous tissue complicating pregnancy, childbirth and the puerperium	0.235	0.765	0.000
O99.5 Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium	0.235	0.765	0.000
O99.4 Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium	0.235	0.765	0.000
O99.1 Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium	0.235	0.765	0.000
S90-S99 Injuries to the ankle and foot	0.235	0.765	0.000
E11 Non-insulin-dependent diabetes mellitus	0.234	0.766	0.000
O14.2 HELLP syndrome	0.234	0.766	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.233	0.767	0.000
S20-S29 Injuries to the thorax	0.233	0.767	0.000
E40-E46 Malnutrition	0.233	0.767	0.000
I80.1 Phlebitis and thrombophlebitis of femoral vein	0.232	0.768	0.000
S42 Fracture of shoulder and upper arm	0.232	0.768	0.000
Z95.2 Presence of prosthetic heart valve	0.232	0.768	0.000
O86 Other puerperal infections	0.232	0.768	0.000
E85.9 Amyloidosis, unspecified	0.231	0.769	0.000
H65-H75 Diseases of middle ear and mastoid	0.231	0.769	0.000
H61 Other disorders of external ear	0.231	0.769	0.000
D55-D59 Haemolytic anaemias	0.231	0.769	0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.231	0.769	0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts	0.231	0.769	0.000
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified	0.230	0.770	0.000
S70 Superficial injury of hip and thigh	0.230	0.770	0.000
O60-O75 Complications of labour and delivery	0.230	0.770	0.000
I82.2 Embolism and thrombosis of vena cava	0.230	0.770	0.000
F32 Depressive episode	0.229	0.771	0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes	0.228	0.772	0.000
I82.3 Embolism and thrombosis of renal vein	0.228	0.772	0.000
I82.1 Thrombophlebitis migrans	0.228	0.772	0.000
I82.0 Budd-Chiari syndrome	0.228	0.772	0.000
S72 Fracture of femur	0.227	0.773	0.000
E06 Thyroiditis	0.226	0.774	0.000
G95 Other diseases of spinal cord	0.226	0.774	0.000
M15.9 Polyarthrosis, unspecified	0.002	0.774	0.224
M15.0 Primary generalised (osteo)arthrosis	0.002	0.774	0.224
M15.8 Other polyarthrosis	0.002	0.774	0.224
M15.4 Erosive (osteo)arthrosis	0.002	0.774	0.224
M15.3 Secondary multiple arthrosis	0.002	0.774	0.224
M15.2 Bouchard's nodes (with arthropathy)	0.002	0.774	0.224
M15.1 Heberden's nodes (with arthropathy)	0.002	0.774	0.224
G45.9 Transient cerebral ischaemic attack, unspecified	0.225	0.775	0.000
G09 Sequelae of inflammatory diseases of central nervous system	0.225	0.775	0.000
T22 Burn and corrosion of shoulder and upper limb, except wrist and hand	0.224	0.776	0.000
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere	0.224	0.776	0.000
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere	0.224	0.776	0.000
I98.0 Cardiovascular syphilis	0.224	0.776	0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts	0.224	0.776	0.000
G50-G59 Nerve, nerve root and plexus disorders	0.224	0.776	0.000
Z95.9 Presence of cardiac and vascular implant and graft, unspecified	0.224	0.776	0.000
T82.1 Mechanical complication of cardiac electronic device	0.224	0.776	0.000
T20 Burn and corrosion of head and neck	0.223	0.777	0.000
M19.29 Other secondary arthrosis (Site unspecified)	0.000	0.777	0.223
M19.28 Other secondary arthrosis (Other)	0.000	0.777	0.223
M19.27 Other secondary arthrosis (Ankle and foot)	0.000	0.777	0.223
M19.26 Other secondary arthrosis of other joints-Lower leg	0.000	0.777	0.223
M19.25 Other secondary arthrosis (Pelvic region and thigh)	0.000	0.777	0.223
M19.24 Other secondary arthrosis (Hand)	0.000	0.777	0.223
M19.23 Other secondary arthrosis (Forearm)	0.000	0.777	0.223
M19.22 Other secondary arthrosis (Upper arm)	0.000	0.777	0.223
M19.21 Other secondary arthrosis (Shoulder region)	0.000	0.777	0.223
M19.20 Other secondary arthrosis (Multiple sites)	0.000	0.777	0.223
M19.89 Other specified arthrosis (Site unspecified)	0.000	0.777	0.223
M19.88 Other specified arthrosis (Other)	0.000	0.777	0.223
M19.87 Other specified arthrosis (Ankle and foot)	0.000	0.777	0.223
M19.86 Other specified arthrosis (Lower leg)	0.000	0.777	0.223
M19.85 Other specified arthrosis (Pelvic region and thigh)	0.000	0.777	0.223
M19.84 Other specified arthrosis (Hand)	0.000	0.777	0.223
M19.83 Other specified arthrosis (Forearm)	0.000	0.777	0.223
M19.82 Other specified arthrosis (Upper arm)	0.000	0.777	0.223
M19.81 Other specified arthrosis (Shoulder region)	0.000	0.777	0.223
M19.80 Other specified arthrosis (Multiple sites)	0.000	0.777	0.223
G70-G73 Diseases of myoneural junction and muscle	0.223	0.777	0.000
T87 Complications peculiar to reattachment and amputation	0.222	0.778	0.000
S46 Injury of muscle and tendon at shoulder and upper arm level	0.222	0.778	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.222	0.778	0.000
O47 False labour	0.220	0.780	0.000
O32 Maternal care for known or suspected malpresentation of foetus	0.220	0.780	0.000
S51 Open wound of forearm	0.220	0.780	0.000
E87.2 Acidosis	0.220	0.780	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.219	0.780	0.000
E74.3 Other disorders of intestinal carbohydrate absorption	0.218	0.781	0.000
F33 Recurrent depressive disorder	0.218	0.781	0.000
O03.9 Complete or unspecified, without complication	0.218	0.781	0.000
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities	0.217	0.782	0.000
D50-D53 Nutritional anaemias	0.218	0.782	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.217	0.783	0.001
F32.1 Moderate depressive episode	0.217	0.783	0.000
I02 Rheumatic chorea	0.217	0.783	0.000
I01 Rheumatic fever with heart involvement	0.217	0.783	0.000
I00 Rheumatic fever without mention of heart involvement	0.217	0.783	0.000
E85.8 Other amyloidosis	0.217	0.783	0.000
E85.4 Organ-limited amyloidosis	0.217	0.783	0.000
E85.2 Heredofamilial amyloidosis, unspecified	0.217	0.783	0.000
E85.1 Neuropathic heredofamilial amyloidosis	0.217	0.783	0.000
E85.0 Nonneuropathic heredofamilial amyloidosis	0.217	0.783	0.000
E03 Other hypothyroidism	0.217	0.783	0.000
G46 Vascular syndromes of brain in cerebrovascular diseases	0.216	0.784	0.000
I28.9 Disease of pulmonary vessels, unspecified	0.216	0.784	0.000
I28.1 Aneurysm of pulmonary artery	0.216	0.784	0.000
I28.0 Arteriovenous fistula of pulmonary vessels	0.216	0.784	0.000
G61.8 Other inflammatory polyneuropathies	0.216	0.784	0.000
T33-T35 Frostbite	0.215	0.784	0.000
T26-T28 Burns and corrosions confined to eye and internal organs	0.215	0.784	0.000
T00-T07 Injuries involving multiple body regions	0.215	0.784	0.000
O02.9 Abnormal product of conception, unspecified	0.215	0.784	0.000
O02.8 Other specified abnormal products of conception	0.215	0.784	0.000
O02.0 Blighted ovum and nonhydatidiform mole	0.215	0.784	0.000
E11.4 With neurological complications	0.215	0.785	0.000
I86.4 Gastric varices	0.214	0.786	0.000
O40 Polyhydramnios	0.214	0.786	0.000
O45 Premature separation of placenta [abruptio placentae]	0.214	0.786	0.000
O33 Maternal care for known or suspected disproportion	0.214	0.786	0.000
O31 Complications specific to multiple gestation	0.214	0.786	0.000
M50-M54 Other dorsopathies	0.214	0.786	0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.214	0.786	0.000
G41 Status epilepticus	0.213	0.786	0.000
I99 Other and unspecified disorders of circulatory system	0.213	0.787	0.000
T31 Burns classified according to extent of body surface involved	0.213	0.787	0.000
O44 Placenta praevia	0.213	0.787	0.000
E83 Disorders of mineral metabolism	0.213	0.787	0.000
O03.8 Complete or unspecified, with other and unspecified complications	0.213	0.787	0.000
O03.7 Complete or unspecified, complicated by embolism	0.213	0.787	0.000
O03.6 Complete or unspecified, complicated by delayed or excessive haemorrhage	0.213	0.787	0.000
O03.5 Complete or unspecified, complicated by genital tract and pelvic infection	0.213	0.787	0.000
O03.3 Incomplete, with other and unspecified complications	0.213	0.787	0.000
O03.2 Incomplete, complicated by embolism	0.213	0.787	0.000
O03.1 Incomplete, complicated by delayed or excessive haemorrhage	0.213	0.787	0.000
O03.0 Incomplete, complicated by genital tract and pelvic infection	0.213	0.787	0.000
H60 Otitis externa	0.213	0.787	0.000
G03 Meningitis due to other and unspecified causes	0.213	0.787	0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.213	0.787	0.000
E10 Insulin-dependent diabetes mellitus	0.213	0.787	0.000
O36.5 Maternal care for poor foetal growth	0.212	0.788	0.000
O99.6 Diseases of the digestive system complicating pregnancy, childbirth and the puerperium	0.212	0.788	0.000
T86 Failure and rejection of transplanted organs and tissues	0.211	0.789	0.000
E14 Unspecified diabetes mellitus	0.211	0.789	0.000
I27 Other pulmonary heart diseases	0.211	0.789	0.000
F99-F99 Unspecified mental disorder	0.211	0.789	0.000
O43 Placental disorders	0.210	0.790	0.000
G63.2 Diabetic polyneuropathy	0.210	0.790	0.000
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere	0.210	0.790	0.000
S80-S89 Injuries to the knee and lower leg	0.209	0.791	0.000
S73 Dislocation, sprain and strain of joint and ligaments of hip	0.208	0.792	0.000
O82 Single delivery by Caesarean section	0.207	0.793	0.000
O92 Other disorders of breast and lactation associated with childbirth	0.206	0.794	0.000
O91 Infections of breast associated with childbirth	0.206	0.794	0.000
O89 Complications of anaesthesia during the puerperium	0.206	0.794	0.000
O88 Obstetric embolism	0.206	0.794	0.000
O87 Venous complications in the puerperium	0.206	0.794	0.000
O85 Puerperal sepsis	0.206	0.794	0.000
G60 Hereditary and idiopathic neuropathy	0.206	0.794	0.000
G64 Other disorders of peripheral nervous system	0.206	0.794	0.000
T82.3 Mechanical complication of other vascular grafts	0.206	0.794	0.000
O90 Complications of the puerperium, not elsewhere classified	0.206	0.794	0.000
D68 Other coagulation defects	0.205	0.795	0.000
O30 Multiple gestation	0.205	0.795	0.000
G44.8 Other specified headache syndromes	0.205	0.795	0.000
G44.4 Drug-induced headache, not elsewhere classified	0.205	0.795	0.000
G44.3 Chronic posttraumatic headache	0.205	0.795	0.000
G44.1 Vascular headache, not elsewhere classified	0.205	0.795	0.000
G44.0 Cluster headache syndrome	0.205	0.795	0.000
M54 Dorsalgia	0.205	0.795	0.000
H62 Disorders of external ear in diseases classified elsewhere	0.205	0.795	0.000
E12 Malnutrition-related diabetes mellitus	0.205	0.795	0.000
S42.0 Fracture of clavicle	0.204	0.796	0.000
I97.9 Postprocedural disorder of circulatory system, unspecified	0.204	0.796	0.000
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified	0.204	0.796	0.000
I97.2 Postmastectomy lymphoedema syndrome	0.204	0.796	0.000
I97.0 Postcardiotomy syndrome	0.204	0.796	0.000
D50 Iron deficiency anaemia	0.204	0.796	0.000
S70.8 Other superficial injuries of hip and thigh	0.204	0.796	0.000
O34.8 Maternal care for other abnormalities of pelvic organs	0.204	0.796	0.000
H80.9 Otosclerosis, unspecified	0.203	0.797	0.000
E87.6 Hypokalaemia	0.202	0.798	0.000
T85.9 Unspecified complication of internal prosthetic device, implant and graft	0.202	0.798	0.000
I83 Varicose veins of lower extremities	0.202	0.798	0.000
E74.9 Disorder of carbohydrate metabolism, unspecified	0.201	0.799	0.000
E74.8 Other specified disorders of carbohydrate metabolism	0.201	0.799	0.000
E74.4 Disorders of pyruvate metabolism and gluconeogenesis	0.201	0.799	0.000
E74.2 Disorders of galactose metabolism	0.201	0.799	0.000
E74.1 Disorders of fructose metabolism	0.201	0.799	0.000
E74.0 Glycogen storage disease	0.201	0.799	0.000
S72.0 Fracture of neck of femur	0.200	0.800	0.000
I87 Other disorders of veins	0.200	0.800	0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants	0.200	0.800	0.000
G45.2 Multiple and bilateral precerebral artery syndromes	0.199	0.801	0.000
G45.1 Carotid artery syndrome (hemispheric)	0.199	0.801	0.000
G45.0 Vertebro-basilar artery syndrome	0.199	0.801	0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts	0.199	0.801	0.000
G90 Disorders of autonomic nervous system	0.198	0.802	0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.198	0.802	0.000
G45.8 Other transient cerebral ischaemic attacks and related syndromes	0.197	0.803	0.000
E50-E64 Other nutritional deficiencies	0.197	0.803	0.000
T82.0 Mechanical complication of heart valve prosthesis	0.197	0.803	0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified	0.197	0.803	0.000
O04 Medical abortion	0.197	0.803	0.000
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft	0.197	0.803	0.000
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis	0.197	0.803	0.000
T82.4 Mechanical complication of vascular dialysis catheter	0.197	0.803	0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts	0.197	0.803	0.000
T88.7 Unspecified adverse effect of drug or medicament	0.196	0.803	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.196	0.804	0.000
E00 Congenital iodine-deficiency syndrome	0.196	0.804	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.196	0.804	0.000
F80-F89 Disorders of psychological development	0.196	0.804	0.000
G06 Intracranial and intraspinal abscess and granuloma	0.196	0.804	0.000
G02 Meningitis in other infectious and parasitic diseases classified elsewhere	0.196	0.804	0.000
G00 Bacterial meningitis, not elsewhere classified	0.196	0.804	0.000
G08 Intracranial and intraspinal phlebitis and thrombophlebitis	0.196	0.804	0.000
G07 Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere	0.196	0.804	0.000
G01 Meningitis in bacterial diseases classified elsewhere	0.196	0.804	0.000
F34 Persistent mood [affective] disorders	0.196	0.804	0.000
O86.4 Pyrexia of unknown origin following delivery	0.196	0.804	0.000
G99 Other disorders of nervous system in diseases classified elsewhere	0.196	0.804	0.000
S41 Open wound of shoulder and upper arm	0.195	0.805	0.000
E65-E68 Obesity and other hyperalimentation	0.195	0.805	0.000
S49 Other and unspecified injuries of shoulder and upper arm	0.195	0.805	0.000
O80 Single spontaneous delivery	0.195	0.805	0.000
S40 Superficial injury of shoulder and upper arm	0.195	0.805	0.000
O84 Multiple delivery	0.194	0.805	0.000
O83 Other assisted single delivery	0.194	0.805	0.000
I88.9 Nonspecific lymphadenitis, unspecified	0.194	0.805	0.000
I88.8 Other nonspecific lymphadenitis	0.194	0.805	0.000
I88.1 Chronic lymphadenitis, except mesenteric	0.194	0.805	0.000
I88.0 Nonspecific mesenteric lymphadenitis	0.194	0.805	0.000
S19 Other and unspecified injuries of neck	0.194	0.806	0.000
I05 Rheumatic mitral valve diseases	0.194	0.806	0.000
O36.8 Maternal care for other specified foetal problems	0.194	0.806	0.000
M50 Cervical disk disorders	0.194	0.806	0.000
M54.5 Low back pain	0.194	0.806	0.000
S48 Traumatic amputation of shoulder and upper arm	0.193	0.806	0.000
S45 Injury of blood vessels at shoulder and upper arm level	0.193	0.806	0.000
S44 Injury of nerves at shoulder and upper arm level	0.193	0.806	0.000
S47 Crushing injury of shoulder and upper arm	0.193	0.806	0.000
T23 Burn and corrosion of wrist and hand	0.193	0.807	0.000
S78 Traumatic amputation of hip and thigh	0.193	0.807	0.000
S77 Crushing injury of hip and thigh	0.193	0.807	0.000
S76 Injury of muscle and tendon at hip and thigh level	0.193	0.807	0.000
S75 Injury of blood vessels at hip and thigh level	0.193	0.807	0.000
S74 Injury of nerves at hip and thigh level	0.193	0.807	0.000
S71 Open wound of hip and thigh	0.193	0.807	0.000
O70 Perineal laceration during delivery	0.193	0.807	0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle	0.193	0.807	0.000
M54.59 Low back pain (Site unspecified)	0.193	0.807	0.000
H81.1 Benign paroxysmal vertigo	0.193	0.807	0.000
I07 Rheumatic tricuspid valve diseases	0.192	0.807	0.000
O41 Other disorders of amniotic fluid and membranes	0.192	0.807	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations