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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs78535563
log Bayes Factor = 12.3274
Chromosome 6   position 12,397,127  (GRCh37) Explore rs78535563 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
J30-J39 Other diseases of upper respiratory tract
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter X Diseases of the respiratory system
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
M20-M25 Other joint disorders
0.999 0.001 0.000
I20-I25 Ischaemic heart diseases
0.998 0.002 0.000
J34 Other disorders of nose and nasal sinuses
0.998 0.002 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.997 0.003 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.997 0.003 0.000
M20 Acquired deformities of fingers and toes
0.995 0.005 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.993 0.007 0.000
I25 Chronic ischaemic heart disease
0.993 0.007 0.000
R06 Abnormalities of breathing
0.991 0.009 0.000
J33 Nasal polyp
0.991 0.009 0.000
J34.2 Deviated nasal septum
0.982 0.018 0.000
M20.2 Hallux rigidus
0.979 0.021 0.000
I25.1 Atherosclerotic heart disease
0.976 0.024 0.000
R30-R39 Symptoms and signs involving the urinary system
0.973 0.027 0.000
J32 Chronic sinusitis
0.972 0.028 0.000
R06.0 Dyspnoea
0.971 0.029 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.968 0.032 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.959 0.041 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.953 0.047 0.000
M20.5 Other deformities of toe(s) (acquired)
0.951 0.049 0.000
J33.9 Nasal polyp, unspecified
0.947 0.053 0.000
Chapter VIII Diseases of the ear and mastoid process
0.945 0.055 0.000
R39 Other symptoms and signs involving the urinary system
0.944 0.056 0.000
I21 Acute myocardial infarction
0.941 0.059 0.000
I73 Other peripheral vascular diseases
0.940 0.060 0.000
J40-J47 Chronic lower respiratory diseases
0.939 0.061 0.000
J33.0 Polyp of nasal cavity
0.938 0.062 0.000
M35 Other systemic involvement of connective tissue
0.937 0.063 0.000
J34.3 Hypertrophy of nasal turbinates
0.935 0.065 0.000
M45-M49 Spondylopathies
0.929 0.071 0.000
I73.9 Peripheral vascular disease, unspecified
0.921 0.079 0.000
I30-I52 Other forms of heart disease
0.920 0.080 0.000
R39.1 Other difficulties with micturition
0.908 0.092 0.000
E10-E14 Diabetes mellitus
0.908 0.092 0.000
I35 Nonrheumatic aortic valve disorders
0.908 0.092 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.903 0.097 0.000
Chapter VI Diseases of the nervous system
0.900 0.100 0.000
I74 Arterial embolism and thrombosis
0.899 0.101 0.000
I71 Aortic aneurysm and dissection
0.899 0.101 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.897 0.103 0.000
R35 Polyuria
0.893 0.107 0.000
I21.4 Acute subendocardial myocardial infarction
0.892 0.108 0.000
Chapter I Certain infectious and parasitic diseases
0.888 0.112 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.886 0.114 0.000
R06.8 Other and unspecified abnormalities of breathing
0.884 0.116 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.882 0.117 0.000
M48 Other spondylopathies
0.882 0.118 0.000
J42 Unspecified chronic bronchitis
0.881 0.119 0.000
R06.5 Mouth breathing
0.870 0.130 0.000
E11 Non-insulin-dependent diabetes mellitus
0.863 0.137 0.000
J32.9 Chronic sinusitis, unspecified
0.862 0.138 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.860 0.140 0.000
H65-H75 Diseases of middle ear and mastoid
0.860 0.140 0.000
R03 Abnormal blood-pressure reading, without diagnosis
0.857 0.143 0.000
M35.3 Polymyalgia rheumatica
0.857 0.143 0.000
R26 Abnormalities of gait and mobility
0.855 0.145 0.000
E00-E07 Disorders of thyroid gland
0.854 0.146 0.000
I77 Other disorders of arteries and arterioles
0.852 0.148 0.000
J32.8 Other chronic sinusitis
0.849 0.150 0.000
J43 Emphysema
0.847 0.153 0.000
M48.0 Spinal stenosis
0.846 0.154 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.846 0.154 0.000
I20 Angina pectoris
0.844 0.156 0.000
M20.4 Other hammer toe(s) (acquired)
0.841 0.159 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.840 0.160 0.000
I70 Atherosclerosis
0.836 0.164 0.000
I35.0 Aortic (valve) stenosis
0.831 0.169 0.000
J90-J94 Other diseases of pleura
0.831 0.169 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.829 0.171 0.000
M24 Other specific joint derangements
0.829 0.171 0.000
Chapter XX External causes of morbidity and mortality
0.827 0.173 0.000
J34.8 Other specified disorders of nose and nasal sinuses
0.826 0.174 0.000
J34.0 Abscess, furuncle and carbuncle of nose
0.825 0.175 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.824 0.176 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.824 0.176 0.000
I49 Other cardiac arrhythmias
0.823 0.177 0.000
J32.2 Chronic ethmoidal sinusitis
0.822 0.178 0.000
J39 Other diseases of upper respiratory tract
0.822 0.178 0.000
M35.7 Hypermobility syndrome
0.820 0.180 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.817 0.183 0.000
M15-M19 Arthrosis
0.816 0.184 0.000
J20-J22 Other acute lower respiratory infections
0.816 0.184 0.000
J92 Pleural plaque
0.814 0.186 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.811 0.188 0.000
E10 Insulin-dependent diabetes mellitus
0.808 0.192 0.000
R06.4 Hyperventilation
0.806 0.194 0.000
Chapter XXII Codes for special purposes
0.806 0.194 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.805 0.195 0.000
A30-A49 Other bacterial diseases
0.804 0.196 0.000
R30 Pain associated with micturition
0.804 0.196 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.797 0.203 0.000
R26.8 Other and unspecified abnormalities of gait and mobility
0.797 0.203 0.000
G20-G26 Extrapyramidal and movement disorders
0.797 0.203 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.796 0.204 0.000
I25.2 Old myocardial infarction
0.789 0.211 0.000
R39.8 Other and unspecified symptoms and signs involving the urinary system
0.789 0.211 0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.788 0.212 0.000
T79-T79 Certain early complications of trauma
0.787 0.213 0.000
J09-J18 Influenza and pneumonia
0.785 0.215 0.000
I72 Other aneurysm
0.784 0.216 0.000
I38 Endocarditis, valve unspecified
0.782 0.218 0.000
M48.02 Spinal stenosis (Cervical region)
0.782 0.218 0.000
J43.9 Emphysema, unspecified
0.782 0.218 0.000
T43.2 Other and unspecified antidepressants
0.781 0.219 0.000
M65-M68 Disorders of synovium and tendon
0.781 0.219 0.000
H90-H95 Other disorders of ear
0.775 0.225 0.000
G90-G99 Other disorders of the nervous system
0.774 0.226 0.000
I35.1 Aortic (valve) insufficiency
0.774 0.226 0.000
M22 Disorders of patella
0.773 0.227 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.773 0.227 0.000
I25.5 Ischaemic cardiomyopathy
0.773 0.227 0.000
Chapter VII Diseases of the eye and adnexa
0.773 0.227 0.000
E11.5 With peripheral circulatory complications
0.771 0.229 0.000
M91-M94 Chondropathies
0.770 0.230 0.000
J32.0 Chronic maxillary sinusitis
0.768 0.232 0.000
J92.9 Pleural plaque without asbestos
0.765 0.234 0.000
J37 Chronic laryngitis and laryngotracheitis
0.765 0.235 0.000
I77.1 Stricture of artery
0.764 0.236 0.000
T66-T78 Other and unspecified effects of external causes
0.763 0.237 0.000
M20.3 Other deformity of hallux (acquired)
0.763 0.237 0.000
M50-M54 Other dorsopathies
0.762 0.238 0.000
E20-E35 Disorders of other endocrine glands
0.761 0.239 0.000
J33.8 Other polyp of sinus
0.759 0.241 0.000
J92.0 Pleural plaque with presence of asbestos
0.758 0.242 0.000
S50-S59 Injuries to the elbow and forearm
0.757 0.243 0.000
E65-E68 Obesity and other hyperalimentation
0.756 0.244 0.000
H60-H62 Diseases of external ear
0.754 0.246 0.000
M80-M85 Disorders of bone density and structure
0.753 0.247 0.000
R06.2 Wheezing
0.753 0.247 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.753 0.247 0.000
R32 Unspecified urinary incontinence
0.751 0.249 0.000
J31 Chronic rhinitis, nasopharyngitis and pharyngitis
0.750 0.250 0.000
S90-S99 Injuries to the ankle and foot
0.749 0.251 0.000
M18 Arthrosis of first carpometacarpal joint
0.746 0.254 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.746 0.254 0.000
M40-M43 Deforming dorsopathies
0.746 0.254 0.000
I20.0 Unstable angina
0.746 0.254 0.000
M17 Gonarthrosis [arthrosis of knee]
0.745 0.255 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.744 0.256 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.744 0.256 0.000
E40-E46 Malnutrition
0.743 0.257 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.743 0.257 0.000
H74 Other disorders of middle ear and mastoid
0.742 0.258 0.000
M34 Systemic sclerosis
0.742 0.258 0.000
R09.1 Pleurisy
0.739 0.261 0.000
R26.3 Immobility
0.738 0.262 0.000
R05 Cough
0.735 0.265 0.000
E11.9 Without complications
0.735 0.265 0.000
R03.1 Nonspecific low blood-pressure reading
0.734 0.266 0.000
M21 Other acquired deformities of limbs
0.733 0.267 0.000
E04 Other non-toxic goitre
0.733 0.267 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.732 0.268 0.000
I05-I09 Chronic rheumatic heart diseases
0.730 0.270 0.000
R09.3 Abnormal sputum
0.729 0.271 0.000
M00-M03 Infectious arthropathies
0.729 0.271 0.000
J47 Bronchiectasis
0.729 0.271 0.000
M86-M90 Other osteopathies
0.728 0.272 0.000
I45 Other conduction disorders
0.728 0.272 0.000
J44 Other chronic obstructive pulmonary disease
0.728 0.272 0.000
S80-S89 Injuries to the knee and lower leg
0.724 0.276 0.000
Chapter II Neoplasms
0.723 0.277 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.722 0.278 0.000
J30 Vasomotor and allergic rhinitis
0.721 0.279 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.720 0.280 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.720 0.280 0.000
H71 Cholesteatoma of middle ear
0.719 0.281 0.000
M48.07 Spinal stenosis (Lumbosacral region)
0.718 0.282 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.716 0.284 0.000
M33 Dermatopolymyositis
0.716 0.284 0.000
M32 Systemic lupus erythematosus
0.716 0.284 0.000
M30 Polyarteritis nodosa and related conditions
0.716 0.284 0.000
I23 Certain current complications following acute myocardial infarction
0.716 0.284 0.000
J36 Peritonsillar abscess
0.716 0.284 0.000
J34.1 Cyst and mucocele of nose and nasal sinus
0.716 0.284 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.715 0.285 0.000
I35.8 Other aortic valve disorders
0.715 0.285 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.715 0.285 0.000
J00-J06 Acute upper respiratory infections
0.714 0.286 0.000
R34 Anuria and oliguria
0.713 0.287 0.000
R72 Abnormality of white blood cells, not elsewhere classified
0.712 0.288 0.000
I25.6 Silent myocardial ischaemia
0.712 0.288 0.000
I25.4 Coronary artery aneurysm
0.712 0.288 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.712 0.288 0.000
C64-C68 Malignant neoplasms of urinary tract
0.711 0.289 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.711 0.289 0.000
R06.7 Sneezing
0.710 0.290 0.000
R06.6 Hiccough
0.710 0.290 0.000
R06.3 Periodic breathing
0.710 0.290 0.000
R06.1 Stridor
0.710 0.290 0.000
J33.1 Polypoid sinus degeneration
0.710 0.290 0.000
H91 Other hearing loss
0.710 0.290 0.000
R02 Gangrene, not elsewhere classified
0.708 0.292 0.000
E10.4 With neurological complications
0.708 0.292 0.000
H30-H36 Disorders of choroid and retina
0.707 0.293 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.707 0.293 0.000
I25.3 Aneurysm of heart
0.706 0.294 0.000
G30-G32 Other degenerative diseases of the nervous system
0.706 0.294 0.000
M17.1 Other primary gonarthrosis
0.706 0.294 0.000
M25 Other joint disorders, not elsewhere classified
0.705 0.295 0.000
J39.8 Other specified diseases of upper respiratory tract
0.704 0.296 0.000
M48.09 Spinal stenosis (Site unspecified)
0.703 0.297 0.000
I70.2 Atherosclerosis of arteries of the extremities
0.702 0.298 0.000
A41 Other septicaemia
0.701 0.299 0.000
J60-J70 Lung diseases due to external agents
0.699 0.301 0.000
R09.0 Asphyxia
0.698 0.302 0.000
R36 Urethral discharge
0.697 0.302 0.000
J32.4 Chronic pansinusitis
0.697 0.303 0.000
J32.3 Chronic sphenoidal sinusitis
0.697 0.303 0.000
J32.1 Chronic frontal sinusitis
0.697 0.303 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.695 0.305 0.000
S40-S49 Injuries to the shoulder and upper arm
0.694 0.305 0.000
J95-J99 Other diseases of the respiratory system
0.694 0.306 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.694 0.306 0.000
E11.3 With ophthalmic complications
0.694 0.306 0.000
R04 Haemorrhage from respiratory passages
0.693 0.307 0.000
E07 Other disorders of thyroid
0.691 0.309 0.000
G20 Parkinson's disease
0.691 0.309 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.690 0.310 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.689 0.311 0.000
B95-B98 Bacterial, viral and other infectious agents
0.689 0.311 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.688 0.312 0.000
T33-T35 Frostbite
0.688 0.312 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.688 0.312 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.688 0.312 0.000
T00-T07 Injuries involving multiple body regions
0.688 0.312 0.000
S10-S19 Injuries to the neck
0.688 0.312 0.000
I49.9 Cardiac arrhythmia, unspecified
0.686 0.314 0.000
E10.3 With ophthalmic complications
0.685 0.315 0.000
A80-A89 Viral infections of the central nervous system
0.684 0.316 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.683 0.317 0.000
R26.2 Difficulty in walking, not elsewhere classified
0.681 0.319 0.000
B25-B34 Other viral diseases
0.680 0.320 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.680 0.320 0.000
M46 Other inflammatory spondylopathies
0.678 0.322 0.000
M31 Other necrotising vasculopathies
0.677 0.322 0.000
R39.2 Extrarenal uraemia
0.677 0.323 0.000
R39.0 Extravasation of urine
0.677 0.323 0.000
I51 Complications and ill-defined descriptions of heart disease
0.675 0.325 0.000
T90 Sequelae of injuries of head
0.675 0.325 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.675 0.325 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.675 0.325 0.000
I73.8 Other specified peripheral vascular diseases
0.674 0.326 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.674 0.326 0.000
M18.9 Arthrosis of first carpometacarpal joint, unspecified
0.674 0.326 0.000
C67 Malignant neoplasm of bladder
0.674 0.326 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.674 0.326 0.000
E11.0 With coma
0.673 0.326 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.673 0.327 0.000
J41 Simple and mucopurulent chronic bronchitis
0.673 0.327 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.672 0.328 0.000
H80-H83 Diseases of inner ear
0.672 0.328 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.672 0.328 0.000
M35.8 Other specified systemic involvement of connective tissue
0.672 0.328 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.672 0.328 0.000
M35.5 Multifocal fibrosclerosis
0.672 0.328 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.672 0.328 0.000
M35.2 Behcet's disease
0.672 0.328 0.000
M35.1 Other overlap syndromes
0.672 0.328 0.000
H35 Other retinal disorders
0.671 0.329 0.000
I47 Paroxysmal tachycardia
0.667 0.333 0.000
M22.8 Other disorders of patella
0.667 0.333 0.000
M49 Spondylopathies in diseases classified elsewhere
0.666 0.334 0.000
M48.00 Spinal stenosis (Multiple sites in spine)
0.665 0.334 0.000
M24.2 Disorder of ligament
0.664 0.336 0.000
R03.0 Elevated blood-pressure reading, without diagnosis of hypertension
0.664 0.336 0.000
H91.9 Hearing loss, unspecified
0.664 0.336 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.663 0.337 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.663 0.337 0.000
C64 Malignant neoplasm of kidney, except renal pelvis
0.663 0.337 0.000
R42 Dizziness and giddiness
0.662 0.338 0.000
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.662 0.338 0.000
I74.5 Embolism and thrombosis of iliac artery
0.661 0.338 0.000
I52 Other heart disorders in diseases classified elsewhere
0.660 0.340 0.000
I48 Atrial fibrillation and flutter
0.660 0.340 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.660 0.340 0.000
I41 Myocarditis in diseases classified elsewhere
0.660 0.340 0.000
I40 Acute myocarditis
0.660 0.340 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.660 0.340 0.000
I37 Pulmonary valve disorders
0.660 0.340 0.000
I36 Nonrheumatic tricuspid valve disorders
0.660 0.340 0.000
I32 Pericarditis in diseases classified elsewhere
0.660 0.340 0.000
I30 Acute pericarditis
0.660 0.340 0.000
E11.2 With renal complications
0.660 0.340 0.000
I24 Other acute ischaemic heart diseases
0.656 0.344 0.000
I22 Subsequent myocardial infarction
0.655 0.345 0.000
R30.0 Dysuria
0.655 0.345 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.653 0.347 0.000
M48.5 Collapsed vertebra, not elsewhere classified
0.653 0.347 0.000
M05-M14 Inflammatory polyarthropathies
0.653 0.347 0.000
E12 Malnutrition-related diabetes mellitus
0.651 0.349 0.000
H69 Other disorders of Eustachian tube
0.650 0.350 0.000
I35.9 Aortic valve disorder, unspecified
0.649 0.351 0.000
I49.3 Ventricular premature depolarisation
0.649 0.351 0.000
M47 Spondylosis
0.648 0.352 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.648 0.352 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.648 0.352 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.648 0.352 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.648 0.352 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.648 0.352 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.648 0.352 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.648 0.352 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.648 0.352 0.000
T36 Poisoning by systemic antibiotics
0.648 0.352 0.000
J15 Bacterial pneumonia, not elsewhere classified
0.646 0.354 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.646 0.354 0.000
M45 Ankylosing spondylitis
0.646 0.354 0.000
I33 Acute and subacute endocarditis
0.646 0.354 0.000
J22 Unspecified acute lower respiratory infection
0.646 0.354 0.000
D55-D59 Haemolytic anaemias
0.645 0.355 0.000
I74.9 Embolism and thrombosis of unspecified artery
0.645 0.355 0.000
I74.8 Embolism and thrombosis of other arteries
0.645 0.355 0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.645 0.355 0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.645 0.355 0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.645 0.355 0.000
I74.0 Embolism and thrombosis of abdominal aorta
0.645 0.355 0.000
H72 Perforation of tympanic membrane
0.645 0.355 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.644 0.355 0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.644 0.355 0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.644 0.355 0.000
I71.3 Abdominal aortic aneurysm, ruptured
0.644 0.355 0.000
I71.1 Thoracic aortic aneurysm, ruptured
0.644 0.355 0.000
I71.0 Dissection of aorta [any part]
0.644 0.355 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.644 0.356 0.000
I78 Diseases of capillaries
0.644 0.356 0.000
R40 Somnolence, stupor and coma
0.644 0.356 0.000
M20.0 Deformity of finger(s)
0.643 0.357 0.000
D80-D89 Certain disorders involving the immune mechanism
0.643 0.357 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.642 0.358 0.000
M84 Disorders of continuity of bone
0.642 0.358 0.000
T51 Toxic effect of alcohol
0.642 0.358 0.000
E10.1 With ketoacidosis
0.642 0.358 0.000
S70-S79 Injuries to the hip and thigh
0.642 0.358 0.000
R73 Elevated blood glucose level
0.641 0.359 0.000
B35-B49 Mycoses
0.640 0.360 0.000
J40 Bronchitis, not specified as acute or chronic
0.638 0.362 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.638 0.362 0.000
R25 Abnormal involuntary movements
0.638 0.362 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.638 0.362 0.000
G25 Other extrapyramidal and movement disorders
0.637 0.363 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.637 0.363 0.000
G95 Other diseases of spinal cord
0.637 0.363 0.000
B99-B99 Other infectious diseases
0.637 0.363 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.637 0.363 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.637 0.363 0.000
B65-B83 Helminthiases
0.637 0.363 0.000
B50-B64 Protozoal diseases
0.637 0.363 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.637 0.363 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.637 0.363 0.000
A75-A79 Rickettsioses
0.637 0.363 0.000
A70-A74 Other diseases caused by chlamydiae
0.637 0.363 0.000
A65-A69 Other spirochaetal diseases
0.637 0.363 0.000
A20-A28 Certain zoonotic bacterial diseases
0.637 0.363 0.000
A15-A19 Tuberculosis
0.637 0.363 0.000
R44.3 Hallucinations, unspecified
0.637 0.363 0.000
H65 Nonsuppurative otitis media
0.636 0.364 0.000
J20 Acute bronchitis
0.636 0.364 0.000
I49.5 Sick sinus syndrome
0.636 0.364 0.000
Q60-Q64 Congenital malformations of the urinary system
0.636 0.364 0.000
I77.9 Disorder of arteries and arterioles, unspecified
0.635 0.365 0.000
R09.2 Respiratory arrest
0.635 0.365 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.635 0.365 0.000
H40-H42 Glaucoma
0.635 0.365 0.000
G70-G73 Diseases of myoneural junction and muscle
0.635 0.365 0.000
H10-H13 Disorders of conjunctiva
0.634 0.366 0.000
I49.1 Atrial premature depolarisation
0.634 0.366 0.000
R45 Symptoms and signs involving emotional state
0.633 0.367 0.000
H35.3 Degeneration of macula and posterior pole
0.633 0.367 0.000
M48.9 Spondylopathy, unspecified
0.632 0.367 0.000
M48.8 Other specified spondylopathies
0.632 0.367 0.000
M48.4 Fatigue fracture of vertebra
0.632 0.367 0.000
M48.3 Traumatic spondylopathy
0.632 0.367 0.000
M48.2 Kissing spine
0.632 0.367 0.000
M48.1 Ankylosing hyperostosis [Forestier]
0.632 0.367 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.632 0.368 0.000
A40 Streptococcal septicaemia
0.631 0.369 0.000
T91 Sequelae of injuries of neck and trunk
0.631 0.369 0.000
C67.9 Bladder, unspecified
0.631 0.369 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.631 0.369 0.000
I70.0 Atherosclerosis of aorta
0.631 0.369 0.000
J38.7 Other diseases of larynx
0.630 0.370 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.630 0.370 0.000
A49 Bacterial infection of unspecified site
0.629 0.371 0.000
T63 Toxic effect of contact with venomous animals
0.629 0.371 0.000
Q23 Congenital malformations of aortic and mitral valves
0.628 0.371 0.000
J38.3 Other diseases of vocal cords
0.627 0.373 0.000
E10.2 With renal complications
0.626 0.374 0.000
A41.9 Septicaemia, unspecified
0.626 0.374 0.000
Y40 Systemic antibiotics
0.625 0.375 0.000
H74.3 Other acquired abnormalities of ear ossicles
0.624 0.376 0.000
M54 Dorsalgia
0.623 0.377 0.000
M24.1 Other articular cartilage disorders
0.622 0.378 0.000
T92 Sequelae of injuries of upper limb
0.621 0.379 0.000
G93 Other disorders of brain
0.620 0.380 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.619 0.381 0.000
E13 Other specified diabetes mellitus
0.619 0.381 0.000
E11.8 With unspecified complications
0.619 0.381 0.000
E11.7 With multiple complications
0.619 0.381 0.000
E11.6 With other specified complications
0.619 0.381 0.000
E11.1 With ketoacidosis
0.619 0.381 0.000
R30.9 Painful micturition, unspecified
0.618 0.382 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.617 0.383 0.000
D68 Other coagulation defects
0.617 0.383 0.000
R46 Symptoms and signs involving appearance and behaviour
0.616 0.383 0.000
R43 Disturbances of smell and taste
0.616 0.383 0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.616 0.384 0.000
H70 Mastoiditis and related conditions
0.616 0.384 0.000
H68 Eustachian salpingitis and obstruction
0.616 0.384 0.000
H67 Otitis media in diseases classified elsewhere
0.616 0.384 0.000
E04.9 Non-toxic goitre, unspecified
0.616 0.384 0.000
M23 Internal derangement of knee
0.615 0.385 0.000
I20.9 Angina pectoris, unspecified
0.615 0.385 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.615 0.385 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.614 0.386 0.000
S31 Open wound of abdomen, lower back and pelvis
0.614 0.386 0.000
Q50-Q56 Congenital malformations of genital organs
0.613 0.387 0.000
R26.1 Paralytic gait
0.613 0.387 0.000
R26.0 Ataxic gait
0.613 0.387 0.000
G96 Other disorders of central nervous system
0.613 0.387 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.612 0.388 0.000
E00 Congenital iodine-deficiency syndrome
0.612 0.388 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.612 0.388 0.000
T68 Hypothermia
0.612 0.388 0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level
0.611 0.388 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.611 0.389 0.000
I77.8 Other specified disorders of arteries and arterioles
0.611 0.389 0.000
I77.5 Necrosis of artery
0.611 0.389 0.000
I77.4 Coeliac artery compression syndrome
0.611 0.389 0.000
I77.3 Arterial fibromuscular dysplasia
0.611 0.389 0.000
I77.2 Rupture of artery
0.611 0.389 0.000
I77.0 Arteriovenous fistula, acquired
0.611 0.389 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.610 0.390 0.000
T42.4 Benzodiazepines
0.610 0.390 0.000
X20-X29 Contact with venomous animals and plants
0.610 0.390 0.000
H66 Suppurative and unspecified otitis media
0.609 0.390 0.000
M35.0 Sicca syndrome [Sjogren]
0.609 0.391 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.609 0.391 0.000
I20.8 Other forms of angina pectoris
0.609 0.391 0.000
M43 Other deforming dorsopathies
0.609 0.391 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.608 0.392 0.000
W20-W49 Exposure to inanimate mechanical forces
0.608 0.392 0.000
J43.8 Other emphysema
0.607 0.392 0.000
J43.2 Centrilobular emphysema
0.607 0.392 0.000
J43.1 Panlobular emphysema
0.607 0.392 0.000
J43.0 MacLeod's syndrome
0.607 0.392 0.000
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.607 0.393 0.000
M48.08 Spinal stenosis (Sacral and sacrococcygeal region)
0.607 0.393 0.000
M48.05 Spinal stenosis (Thoracolumbar region)
0.607 0.393 0.000
M48.04 Spinal stenosis (Thoracic region)
0.607 0.393 0.000
M48.03 Spinal stenosis (Cervicothoracic region)
0.607 0.393 0.000
M48.01 Spinal stenosis (Occipito-atlanto-axial region)
0.607 0.393 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.606 0.393 0.000
Q80-Q89 Other congenital malformations
0.606 0.393 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.606 0.393 0.000
Q35-Q37 Cleft lip and cleft palate
0.606 0.393 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.606 0.393 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.606 0.393 0.000
Q00-Q07 Congenital malformations of the nervous system
0.606 0.393 0.000
R01 Cardiac murmurs and other cardiac sounds
0.606 0.394 0.000
I49.4 Other and unspecified premature depolarisation
0.606 0.394 0.000
M94 Other disorders of cartilage
0.605 0.395 0.000
R09.8 Other specified symptoms and signs involving the circulatory and respiratory systems
0.604 0.396 0.000
E66 Obesity
0.604 0.396 0.000
I72.3 Aneurysm of iliac artery
0.603 0.397 0.000
T43.9 Psychotropic drug, unspecified
0.602 0.398 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.602 0.398 0.000
T43.6 Psychostimulants with abuse potential
0.602 0.398 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.602 0.398 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.602 0.398 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.602 0.398 0.000
M65 Synovitis and tenosynovitis
0.602 0.398 0.000
E50-E64 Other nutritional deficiencies
0.601 0.399 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.600 0.400 0.000
I08 Multiple valve diseases
0.600 0.400 0.000
J13 Pneumonia due to Streptococcus pneumoniae
0.600 0.400 0.000
I70.9 Generalised and unspecified atherosclerosis
0.599 0.401 0.000
I70.8 Atherosclerosis of other arteries
0.599 0.401 0.000
I70.1 Atherosclerosis of renal artery
0.599 0.401 0.000
X60-X84 Intentional self-harm
0.599 0.401 0.000
I42 Cardiomyopathy
0.598 0.402 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.597 0.403 0.000
B15-B19 Viral hepatitis
0.597 0.403 0.000
J37.0 Chronic laryngitis
0.597 0.403 0.000
J94 Other pleural conditions
0.595 0.404 0.000
H60 Otitis externa
0.595 0.405 0.000
M24.9 Joint derangement, unspecified
0.594 0.406 0.000
M24.7 Protrusio acetabuli
0.594 0.406 0.000
M24.6 Ankylosis of joint
0.594 0.406 0.000
M24.5 Contracture of joint
0.594 0.406 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.594 0.406 0.000
M24.0 Loose body in joint
0.594 0.406 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.594 0.406 0.000
S52 Fracture of forearm
0.594 0.406 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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