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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs9264643
log Bayes Factor = 205.849
Chromosome 6   position 31,238,492  (GRCh37) Explore rs9264643 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
E05.0 Thyrotoxicosis with diffuse goitre
1.000 0.000 0.000
K90.0 Coeliac disease
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
G35 Multiple sclerosis
1.000 0.000 0.000
R31 Unspecified haematuria
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
D69 Purpura and other haemorrhagic conditions
1.000 0.000 0.000
M35.0 Sicca syndrome [Sjogren]
1.000 0.000 0.000
E03 Other hypothyroidism
1.000 0.000 0.000
D69.6 Thrombocytopenia, unspecified
1.000 0.000 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
# Top node
1.000 0.000 0.000
I20-I25 Ischaemic heart diseases
0.000 0.001 0.999
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.001 0.999
G35-G37 Demyelinating diseases of the central nervous system
0.999 0.001 0.000
D50-D53 Nutritional anaemias
0.999 0.001 0.000
E10.9 Without complications
0.999 0.001 0.000
E27.1 Primary adrenocortical insufficiency
0.999 0.001 0.000
Chapter VI Diseases of the nervous system
0.999 0.001 0.000
E78.0 Pure hypercholesterolaemia
0.000 0.001 0.999
L40 Psoriasis
0.000 0.002 0.998
E27 Other disorders of adrenal gland
0.998 0.002 0.000
M35 Other systemic involvement of connective tissue
0.998 0.002 0.000
E20-E35 Disorders of other endocrine glands
0.998 0.002 0.000
D51 Vitamin B12 deficiency anaemia
0.998 0.002 0.000
M20-M25 Other joint disorders
0.998 0.002 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.997 0.003 0.000
E10.3 With ophthalmic complications
0.997 0.003 0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.996 0.004 0.000
I20 Angina pectoris
0.000 0.006 0.994
D80-D89 Certain disorders involving the immune mechanism
0.994 0.006 0.000
L40.5 Arthropathic psoriasis
0.000 0.006 0.994
Chapter VII Diseases of the eye and adnexa
0.991 0.009 0.000
H30-H36 Disorders of choroid and retina
0.991 0.009 0.000
H36 Retinal disorders in diseases classified elsewhere
0.989 0.011 0.000
H36.0 Diabetic retinopathy
0.989 0.011 0.000
I20.0 Unstable angina
0.000 0.013 0.987
M60-M63 Disorders of muscles
0.987 0.013 0.000
E10.2 With renal complications
0.985 0.015 0.000
I21 Acute myocardial infarction
0.000 0.018 0.982
I25.2 Old myocardial infarction
0.000 0.022 0.978
I21.9 Acute myocardial infarction, unspecified
0.000 0.022 0.978
G00-G09 Inflammatory diseases of the central nervous system
0.967 0.033 0.000
H34 Retinal vascular occlusions
0.965 0.035 0.000
D80 Immunodeficiency with predominantly antibody defects
0.964 0.036 0.000
E50-E64 Other nutritional deficiencies
0.964 0.036 0.000
M40-M43 Deforming dorsopathies
0.963 0.037 0.000
E14 Unspecified diabetes mellitus
0.962 0.038 0.000
E06 Thyroiditis
0.962 0.038 0.000
M34 Systemic sclerosis
0.962 0.038 0.000
M62 Other disorders of muscle
0.959 0.041 0.000
I22 Subsequent myocardial infarction
0.000 0.043 0.957
L40.0 Psoriasis vulgaris
0.000 0.044 0.956
I20.9 Angina pectoris, unspecified
0.000 0.044 0.956
E53 Deficiency of other B group vitamins
0.948 0.052 0.000
E14.3 With ophthalmic complications
0.947 0.053 0.000
M21 Other acquired deformities of limbs
0.944 0.056 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.057 0.943
M45 Ankylosing spondylitis
0.002 0.058 0.940
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.059 0.941
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.940 0.060 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.934 0.066 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.930 0.070 0.000
E53.8 Deficiency of other specified B group vitamins
0.930 0.070 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.929 0.071 0.000
E10.1 With ketoacidosis
0.929 0.071 0.000
M21.0 Valgus deformity, not elsewhere classified
0.928 0.072 0.000
E06.3 Autoimmune thyroiditis
0.927 0.073 0.000
D60-D64 Aplastic and other anaemias
0.927 0.073 0.000
M43 Other deforming dorsopathies
0.926 0.074 0.000
M62.8 Other specified disorders of muscle
0.924 0.076 0.000
D61 Other aplastic anaemias
0.920 0.080 0.000
H16 Keratitis
0.918 0.082 0.000
M60 Myositis
0.918 0.082 0.000
I25.5 Ischaemic cardiomyopathy
0.000 0.082 0.918
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.082 0.917
H34.2 Other retinal artery occlusions
0.917 0.083 0.000
M21.06 Valgus deformity, not elsewhere classified (Lower leg)
0.915 0.085 0.000
D61.9 Aplastic anaemia, unspecified
0.914 0.086 0.000
G00 Bacterial meningitis, not elsewhere classified
0.911 0.089 0.000
Chapter I Certain infectious and parasitic diseases
0.909 0.091 0.000
M32 Systemic lupus erythematosus
0.908 0.092 0.000
I25.1 Atherosclerotic heart disease
0.000 0.096 0.904
D80.1 Nonfamilial hypogammaglobulinaemia
0.903 0.097 0.000
M34.9 Systemic sclerosis, unspecified
0.900 0.100 0.000
H16.0 Corneal ulcer
0.895 0.105 0.000
M21.8 Other specified acquired deformities of limbs
0.891 0.109 0.000
E16 Other disorders of pancreatic internal secretion
0.887 0.113 0.000
D69.4 Other primary thrombocytopenia
0.886 0.114 0.000
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.117 0.883
H34.8 Other retinal vascular occlusions
0.882 0.118 0.000
D50 Iron deficiency anaemia
0.878 0.122 0.000
G30-G32 Other degenerative diseases of the nervous system
0.874 0.126 0.000
H10-H13 Disorders of conjunctiva
0.874 0.126 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.873 0.127 0.000
H18 Other disorders of cornea
0.873 0.127 0.000
L40.8 Other psoriasis
0.000 0.129 0.871
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.867 0.133 0.000
E07 Other disorders of thyroid
0.860 0.140 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.857 0.143 0.000
G09 Sequelae of inflammatory diseases of central nervous system
0.856 0.144 0.000
M43.0 Spondylolysis
0.854 0.146 0.000
B25-B34 Other viral diseases
0.852 0.148 0.000
M40 Kyphosis and lordosis
0.847 0.153 0.000
E16.2 Hypoglycaemia, unspecified
0.847 0.153 0.000
I25.3 Aneurysm of heart
0.000 0.154 0.846
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.154 0.846
M34.8 Other forms of systemic sclerosis
0.846 0.154 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.844 0.156 0.000
M62.85 Other specified disorders of muscle (Pelvic region and thigh)
0.843 0.157 0.000
M32.1 Systemic lupus erythematosus with organ or system involvement
0.838 0.162 0.000
M35.7 Hypermobility syndrome
0.831 0.169 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.830 0.170 0.000
M62.80 Other specified disorders of muscle (Multiple sites)
0.830 0.170 0.000
E24 Cushing's syndrome
0.829 0.171 0.000
D69.2 Other nonthrombocytopenic purpura
0.829 0.171 0.000
E31 Polyglandular dysfunction
0.827 0.173 0.000
B07 Viral warts
0.827 0.173 0.000
D89.2 Hypergammaglobulinaemia, unspecified
0.826 0.174 0.000
G70-G73 Diseases of myoneural junction and muscle
0.826 0.174 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.175 0.825
H31 Other disorders of choroid
0.824 0.176 0.000
B25 Cytomegaloviral disease
0.824 0.176 0.000
E03.8 Other specified hypothyroidism
0.821 0.179 0.000
M60.9 Myositis, unspecified
0.820 0.180 0.000
D53 Other nutritional anaemias
0.817 0.183 0.000
D69.5 Secondary thrombocytopenia
0.813 0.187 0.000
H46 Optic neuritis
0.813 0.187 0.000
H30 Chorioretinal inflammation
0.809 0.191 0.000
K90 Intestinal malabsorption
0.806 0.194 0.000
M21.86 Other specified acquired deformities of limbs (Lower leg)
0.803 0.197 0.000
G00.1 Pneumococcal meningitis
0.803 0.197 0.000
G08 Intracranial and intraspinal phlebitis and thrombophlebitis
0.802 0.198 0.000
E07.8 Other specified disorders of thyroid
0.802 0.198 0.000
D69.8 Other specified haemorrhagic conditions
0.801 0.199 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.801 0.199 0.000
M43.1 Spondylolisthesis
0.801 0.199 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.800 0.200 0.000
D50.9 Iron deficiency anaemia, unspecified
0.799 0.201 0.000
M43.02 Spondylolysis (Cervical region)
0.799 0.201 0.000
H11 Other disorders of conjunctiva
0.798 0.202 0.000
B25.9 Cytomegaloviral disease, unspecified
0.798 0.202 0.000
M62.81 Other specified disorders of muscle (Shoulder region)
0.797 0.203 0.000
D84 Other immunodeficiencies
0.792 0.208 0.000
E10.7 With multiple complications
0.787 0.212 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.787 0.213 0.000
H18.6 Keratoconus
0.786 0.214 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.786 0.214 0.000
E20 Hypoparathyroidism
0.784 0.216 0.000
M34.0 Progressive systemic sclerosis
0.784 0.216 0.000
D89.9 Disorder involving the immune mechanism, unspecified
0.783 0.217 0.000
E53.9 Vitamin B deficiency, unspecified
0.778 0.222 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.778 0.222 0.000
G00.9 Bacterial meningitis, unspecified
0.775 0.225 0.000
M35.8 Other specified systemic involvement of connective tissue
0.774 0.226 0.000
E34 Other endocrine disorders
0.772 0.227 0.000
H11.0 Pterygium
0.772 0.228 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.772 0.228 0.000
M45.X2 Ankylosing spondylitis (Cervical region)
0.001 0.229 0.770
M62.5 Muscle wasting and atrophy, not elsewhere classified
0.769 0.231 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.766 0.234 0.000
E14.2 Withrenal complications
0.765 0.234 0.000
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.764 0.236 0.000
G62 Other polyneuropathies
0.764 0.236 0.000
H16.9 Keratitis, unspecified
0.763 0.237 0.000
M40.2 Other and unspecified kyphosis
0.762 0.238 0.000
B01 Varicella [chickenpox]
0.761 0.239 0.000
H18.1 Bullous keratopathy
0.760 0.240 0.000
E14.0 With coma
0.759 0.241 0.000
E10.6 With other specified complications
0.758 0.241 0.000
G62.9 Polyneuropathy, unspecified
0.758 0.242 0.000
I23 Certain current complications following acute myocardial infarction
0.000 0.243 0.756
H16.1 Other superficial keratitis without conjunctivitis
0.756 0.244 0.000
E05.8 Other thyrotoxicosis
0.756 0.244 0.000
M62.83 Other specified disorders of muscle (Forearm)
0.754 0.246 0.000
D55-D59 Haemolytic anaemias
0.753 0.247 0.000
D83 Common variable immunodeficiency
0.753 0.247 0.000
E27.8 Other specified disorders of adrenal gland
0.752 0.248 0.000
E51 Thiamine deficiency
0.751 0.249 0.000
M21.85 Other specified acquired deformities of limbs (Pelvic region and thigh)
0.750 0.250 0.000
E27.2 Addisonian crisis
0.749 0.251 0.000
D51.8 Other vitamin B12 deficiency anaemias
0.748 0.252 0.000
H18.3 Changes in corneal membranes
0.748 0.252 0.000
G01 Meningitis in bacterial diseases classified elsewhere
0.748 0.252 0.000
M60.99 Myositis, unspecified (Site unspecified)
0.748 0.252 0.000
E06.9 Thyroiditis, unspecified
0.746 0.254 0.000
D89.0 Polyclonal hypergammaglobulinaemia
0.746 0.254 0.000
E10.0 With coma
0.746 0.254 0.000
M62.2 Ischaemic infarction of muscle
0.745 0.254 0.000
M60.0 Infective myositis
0.745 0.255 0.000
I22.8 Subsequent myocardial infarction of other sites
0.000 0.256 0.743
M00-M03 Infectious arthropathies
0.743 0.257 0.000
E10.8 With unspecified complications
0.742 0.258 0.000
E10.4 With neurological complications
0.740 0.260 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.740 0.260 0.000
M86-M90 Other osteopathies
0.737 0.263 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.734 0.266 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.734 0.266 0.000
G00.2 Streptococcal meningitis
0.733 0.267 0.000
G37 Other demyelinating diseases of central nervous system
0.733 0.267 0.000
E14.6 With other specified complications
0.733 0.267 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.732 0.268 0.000
K90.9 Intestinal malabsorption, unspecified
0.731 0.269 0.000
G36 Other acute disseminated demyelination
0.730 0.269 0.000
D86 Sarcoidosis
0.730 0.270 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.730 0.270 0.000
G31.9 Degenerative disease of nervous system, unspecified
0.728 0.272 0.000
D50.1 Sideropenic dysphagia
0.725 0.275 0.000
G72 Other myopathies
0.724 0.276 0.000
B15-B19 Viral hepatitis
0.724 0.276 0.000
M43.9 Deforming dorsopathy, unspecified
0.722 0.278 0.000
M43.17 Spondylolisthesis (Lumbosacral region)
0.721 0.279 0.000
M60.8 Other myositis
0.721 0.279 0.000
B27 Infectious mononucleosis
0.718 0.282 0.000
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
D69.1 Qualitative platelet defects
0.717 0.283 0.000
E03.5 Myxoedema coma
0.717 0.283 0.000
E03.4 Atrophy of thyroid (acquired)
0.717 0.283 0.000
E03.3 Postinfectious hypothyroidism
0.717 0.283 0.000
D67 Hereditary factor IX deficiency
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.716 0.284 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.284 0.716
L40.4 Guttate psoriasis
0.000 0.284 0.716
L40.2 Acrodermatitis continua
0.000 0.284 0.716
E27.5 Adrenomedullary hyperfunction
0.716 0.284 0.000
E27.0 Other adrenocortical overactivity
0.716 0.284 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.716 0.284 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.716 0.284 0.000
M35.5 Multifocal fibrosclerosis
0.716 0.284 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.716 0.284 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.716 0.284 0.000
E32 Diseases of thymus
0.716 0.284 0.000
E30 Disorders of puberty, not elsewhere classified
0.716 0.284 0.000
D51.3 Other dietary vitamin B12 deficiency anaemia
0.715 0.284 0.000
D51.2 Transcobalamin II deficiency
0.715 0.284 0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.715 0.284 0.000
H16.8 Other keratitis
0.714 0.286 0.000
D81 Combined immunodeficiencies
0.713 0.287 0.000
M21.7 Unequal limb length (acquired)
0.712 0.288 0.000
M43.8 Other specified deforming dorsopathies
0.711 0.289 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.710 0.290 0.000
D70 Agranulocytosis
0.710 0.290 0.000
H36.8 Other retinal disorders in diseases classified elsewhere
0.709 0.291 0.000
H18.5 Hereditary corneal dystrophies
0.708 0.291 0.000
E14.5 With peripheral circulatory complications
0.708 0.292 0.000
D89.1 Cryoglobulinaemia
0.708 0.292 0.000
M63 Disorders of muscle in diseases classified elsewhere
0.708 0.292 0.000
M61 Calcification and ossification of muscle
0.708 0.292 0.000
G06 Intracranial and intraspinal abscess and granuloma
0.707 0.293 0.000
H06.2 Dysthyroid exophthalmos
0.707 0.293 0.000
B24 Unspecified human immunodeficiency virus [HIV] disease
0.706 0.294 0.000
H31.0 Chorioretinal scars
0.706 0.294 0.000
E31.0 Autoimmune polyglandular failure
0.705 0.295 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.296 0.704
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.704 0.296 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.703 0.297 0.000
D72 Other disorders of white blood cells
0.701 0.299 0.000
M62.6 Muscle strain
0.700 0.300 0.000
I24 Other acute ischaemic heart diseases
0.000 0.303 0.697
D61.0 Constitutional aplastic anaemia
0.696 0.304 0.000
M62.86 Other specified disorders of muscle (Lower leg)
0.695 0.305 0.000
M21.83 Other specified acquired deformities of limbs (Forearm)
0.694 0.306 0.000
G07 Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere
0.693 0.307 0.000
M31 Other necrotising vasculopathies
0.692 0.308 0.000
H34.0 Transient retinal artery occlusion
0.692 0.308 0.000
D80.8 Other immunodeficiencies with predominantly antibody defects
0.691 0.309 0.000
D80.7 Transient hypogammaglobulinaemia of infancy
0.691 0.309 0.000
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.691 0.309 0.000
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.691 0.309 0.000
D80.0 Hereditary hypogammaglobulinaemia
0.691 0.309 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.691 0.309 0.000
E63 Other nutritional deficiencies
0.691 0.309 0.000
E56 Other vitamin deficiencies
0.691 0.309 0.000
E50 Vitamin A deficiency
0.691 0.309 0.000
E60 Dietary zinc deficiency
0.691 0.309 0.000
E59 Dietary selenium deficiency
0.691 0.309 0.000
E54 Ascorbic acid deficiency
0.691 0.309 0.000
E52 Niacin deficiency [pellagra]
0.691 0.309 0.000
M62.9 Disorder of muscle, unspecified
0.691 0.309 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.691 0.309 0.000
M42 Spinal osteochondrosis
0.691 0.309 0.000
E14.7 With multiple complications
0.690 0.310 0.000
E06.5 Other chronic thyroiditis
0.690 0.310 0.000
E06.4 Drug-induced thyroiditis
0.690 0.310 0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.690 0.310 0.000
E06.1 Subacute thyroiditis
0.690 0.310 0.000
E06.0 Acute thyroiditis
0.690 0.310 0.000
M34.2 Systemic sclerosis induced by drugs and chemicals
0.689 0.310 0.000
M62.4 Contracture of muscle
0.687 0.312 0.000
M62.3 Immobility syndrome (paraplegic)
0.687 0.312 0.000
D53.9 Nutritional anaemia, unspecified
0.687 0.313 0.000
H34.9 Retinal vascular occlusion, unspecified
0.686 0.314 0.000
D86.9 Sarcoidosis, unspecified
0.686 0.314 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.685 0.315 0.000
G02 Meningitis in other infectious and parasitic diseases classified elsewhere
0.684 0.316 0.000
E55 Vitamin D deficiency
0.683 0.317 0.000
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)
0.683 0.317 0.000
M62.1 Other rupture of muscle (nontraumatic)
0.683 0.317 0.000
A63 Other predominantly sexually transmitted diseases, not elsewhere classified
0.682 0.318 0.000
M23 Internal derangement of knee
0.681 0.319 0.000
E14.4 With neurological complications
0.680 0.320 0.000
E53.1 Pyridoxine deficiency
0.680 0.320 0.000
E53.0 Riboflavin deficiency
0.680 0.320 0.000
H18.0 Corneal pigmentations and deposits
0.678 0.322 0.000
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.678 0.322 0.000
M43.06 Spondylolysis (Lumbar region)
0.677 0.323 0.000
B35-B49 Mycoses
0.676 0.324 0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.002 0.324 0.674
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.002 0.324 0.674
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.002 0.324 0.674
M45.X4 Ankylosing spondylitis (Thoracic region)
0.002 0.324 0.674
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.002 0.324 0.674
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.002 0.324 0.674
D89.3 Immune reconstitution syndrome
0.674 0.326 0.000
L40.1 Generalised pustular psoriasis
0.000 0.326 0.674
B08 Other viral infections characterised by skin and mucous membrane lesions, not elsewhere classified
0.674 0.326 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.674 0.326 0.000
I25.6 Silent myocardial ischaemia
0.000 0.326 0.674
H18.8 Other specified disorders of cornea
0.673 0.327 0.000
M43.2 Other fusion of spine
0.672 0.328 0.000
B16 Acute hepatitis B
0.671 0.329 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.670 0.330 0.000
E24.8 Other Cushing's syndrome
0.670 0.330 0.000
E15 Nondiabetic hypoglycaemic coma
0.670 0.330 0.000
B25.0 Cytomegaloviral pneumonitis
0.669 0.330 0.000
M32.8 Other forms of systemic lupus erythematosus
0.669 0.331 0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.669 0.331 0.000
E14.1 With ketoacidosis
0.667 0.333 0.000
E28 Ovarian dysfunction
0.666 0.333 0.000
M40.29 Other and unspecified kyphosis (Site unspecified)
0.665 0.335 0.000
M21.09 Valgus deformity, not elsewhere classified (Site unspecified)
0.665 0.335 0.000
M21.08 Valgus deformity, not elsewhere classified (Other)
0.665 0.335 0.000
M21.05 Valgus deformity, not elsewhere classified (Pelvic region and thigh)
0.665 0.335 0.000
M21.04 Valgus deformity, not elsewhere classified (Hand)
0.665 0.335 0.000
M21.03 Valgus deformity, not elsewhere classified (Forearm)
0.665 0.335 0.000
M21.02 Valgus deformity, not elsewhere classified (Upper arm)
0.665 0.335 0.000
M21.01 Valgus deformity, not elsewhere classified (Shoulder region)
0.665 0.335 0.000
M21.00 Valgus deformity, not elsewhere classified (Multiple sites)
0.665 0.335 0.000
H11.8 Other specified disorders of conjunctiva
0.664 0.336 0.000
M43.5 Other recurrent vertebral subluxation
0.664 0.336 0.000
M43.4 Other recurrent atlantoaxial subluxation
0.664 0.336 0.000
M43.3 Recurrent atlantoaxial subluxation with myelopathy
0.664 0.336 0.000
M62.87 Other specified disorders of muscle (Ankle and foot)
0.662 0.338 0.000
M62.84 Other specified disorders of muscle (Hand)
0.662 0.338 0.000
I25.4 Coronary artery aneurysm
0.000 0.339 0.661
H30.9 Chorioretinal inflammation, unspecified
0.660 0.339 0.000
G73 Disorders of myoneural junction and muscle in diseases classified elsewhere
0.660 0.340 0.000
D61.8 Other specified aplastic anaemias
0.659 0.341 0.000
D61.3 Idiopathic aplastic anaemia
0.659 0.341 0.000
D61.2 Aplastic anaemia due to other external agents
0.659 0.341 0.000
E29 Testicular dysfunction
0.659 0.341 0.000
M60.1 Interstitial myositis
0.658 0.342 0.000
M45.X6 Ankylosing spondylitis (Lumbar region)
0.002 0.342 0.656
D76.3 Other histiocytosis syndromes
0.658 0.342 0.000
M62.0 Diastasis of muscle
0.657 0.343 0.000
E24.2 Drug-induced Cushing's syndrome
0.655 0.345 0.000
G00.8 Other bacterial meningitis
0.653 0.346 0.000
G00.3 Staphylococcal meningitis
0.653 0.346 0.000
G00.0 Haemophilus meningitis
0.653 0.346 0.000
M60.2 Foreign body granuloma of soft tissue, not elsewhere classified
0.653 0.347 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.653 0.347 0.000
H16.2 Keratoconjunctivitis
0.652 0.347 0.000
E14.8 With unspecified complications
0.652 0.348 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.652 0.348 0.000
A75-A79 Rickettsioses
0.652 0.348 0.000
A70-A74 Other diseases caused by chlamydiae
0.652 0.348 0.000
A20-A28 Certain zoonotic bacterial diseases
0.652 0.348 0.000
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere
0.651 0.348 0.000
I21.4 Acute subendocardial myocardial infarction
0.000 0.349 0.651
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.651 0.349 0.000
M32.9 Systemic lupus erythematosus, unspecified
0.651 0.349 0.000
M32.0 Drug-induced systemic lupus erythematosus
0.651 0.349 0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.651 0.349 0.000
M33 Dermatopolymyositis
0.650 0.350 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.649 0.351 0.000
G31.2 Degeneration of nervous system due to alcohol
0.649 0.351 0.000
D61.1 Drug-induced aplastic anaemia
0.648 0.351 0.000
H11.2 Conjunctival scars
0.648 0.351 0.000
A65-A69 Other spirochaetal diseases
0.648 0.352 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.646 0.353 0.000
M43.19 Spondylolisthesis (Site unspecified)
0.646 0.354 0.000
D69.9 Haemorrhagic condition, unspecified
0.646 0.354 0.000
M62.59 Muscle wasting and atrophy, not elsewhere classified (Site unspecified)
0.645 0.355 0.000
M21.87 Other specified acquired deformities of limbs (Ankle and foot)
0.644 0.356 0.000
B01.9 Varicella without complications
0.644 0.356 0.000
M23.4 Loose body in knee
0.643 0.357 0.000
H16.3 Interstitial and deep keratitis
0.642 0.358 0.000
E03.1 Congenital hypothyroidism without goitre
0.640 0.360 0.000
M21.89 Other specified acquired deformities of limbs (Site unspecified)
0.639 0.361 0.000
M21.88 Other specified acquired deformities of limbs-Other
0.639 0.361 0.000
M21.84 Other specified acquired deformities of limbs (Hand)
0.639 0.361 0.000
M21.82 Other specified acquired deformities of limbs (Upper arm)
0.639 0.361 0.000
M21.81 Other specified acquired deformities of limbs (Shoulder region)
0.639 0.361 0.000
M21.80 Other specified acquired deformities of limbs (Multiple sites)
0.639 0.361 0.000
H02 Other disorders of eyelid
0.638 0.362 0.000
E25 Adrenogenital disorders
0.637 0.362 0.000
D84.9 Immunodeficiency, unspecified
0.637 0.363 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.636 0.364 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.636 0.364 0.000
E16.4 Abnormal secretion of gastrin
0.636 0.364 0.000
E16.3 Increased secretion of glucagon
0.636 0.364 0.000
D64 Other anaemias
0.634 0.366 0.000
D52 Folate deficiency anaemia
0.633 0.367 0.000
B16.9 Acute hepatitis B without delta-agent and without hepatic coma
0.633 0.367 0.000
D69.0 Allergic purpura
0.632 0.367 0.000
D82 Immunodeficiency associated with other major defects
0.632 0.368 0.000
H13 Disorders of conjunctiva in diseases classified elsewhere
0.632 0.368 0.000
M62.82 Other specified disorders of muscle (Upper arm)
0.630 0.370 0.000
D66 Hereditary factor VIII deficiency
0.630 0.370 0.000
E20.9 Hypoparathyroidism, unspecified
0.630 0.370 0.000
H31.8 Other specified disorders of choroid
0.630 0.370 0.000
E58 Dietary calcium deficiency
0.629 0.371 0.000
H34.1 Central retinal artery occlusion
0.628 0.372 0.000
M21.9 Acquired deformity of limb, unspecified
0.628 0.372 0.000
A63.0 Anogenital (venereal) warts
0.628 0.372 0.000
H02.5 Other disorders affecting eyelid function
0.627 0.373 0.000
E34.8 Other specified endocrine disorders
0.626 0.373 0.000
E24.0 Pituitary-dependent Cushing's disease
0.626 0.374 0.000
B06 Rubella [German measles]
0.626 0.374 0.000
B05 Measles
0.626 0.374 0.000
B09 Unspecified viral infection characterised by skin and mucous membrane lesions
0.626 0.374 0.000
B04 Monkeypox
0.626 0.374 0.000
B03 Smallpox
0.626 0.374 0.000
H18.7 Other corneal deformities
0.626 0.374 0.000
M43.10 Spondylolisthesis (Multiple sites in spine)
0.625 0.375 0.000
D72.8 Other specified disorders of white blood cells
0.625 0.375 0.000
M86 Osteomyelitis
0.623 0.377 0.000
H31.9 Disorder of choroid, unspecified
0.623 0.377 0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.377 0.623
M23.49 Loose body in knee-Unspec lig/men
0.622 0.378 0.000
B91 Sequelae of poliomyelitis
0.619 0.381 0.000
E07.1 Dyshormogenetic goitre
0.616 0.384 0.000
E07.0 Hypersecretion of calcitonin
0.616 0.384 0.000
M90 Osteopathies in diseases classified elsewhere
0.616 0.384 0.000
G03 Meningitis due to other and unspecified causes
0.615 0.385 0.000
H48 Disorders of optic [2nd] nerve and visual pathways in diseases classified elsewhere
0.615 0.385 0.000
D59 Acquired haemolytic anaemia
0.615 0.385 0.000
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.386 0.614
H16.4 Corneal neovascularisation
0.614 0.386 0.000
M60.08 Infective myositis (Other)
0.613 0.387 0.000
M40.5 Lordosis, unspecified
0.613 0.387 0.000
B01.2 Varicella pneumonia
0.613 0.387 0.000
M43.08 Spondylolysis (Sacral and sacrococcygeal region)
0.612 0.388 0.000
M43.07 Spondylolysis (Lumbosacral region)
0.612 0.388 0.000
M43.05 Spondylolysis (Thoracolumbar region)
0.612 0.388 0.000
M43.04 Spondylolysis (Thoracic region)
0.612 0.388 0.000
M43.03 Spondylolysis (Cervicothoracic region)
0.612 0.388 0.000
M43.01 Spondylolysis (Occipito-atlanto-axial region)
0.612 0.388 0.000
M43.00 Spondylolysis (Multiple sites in spine)
0.612 0.388 0.000
M30 Polyarteritis nodosa and related conditions
0.611 0.389 0.000
L40.3 Pustulosis palmaris et plantaris
0.000 0.389 0.611
B30 Viral conjunctivitis
0.611 0.389 0.000
B26 Mumps
0.611 0.389 0.000
B00 Herpesviral [herpes simplex] infections
0.608 0.392 0.000
E23 Hypofunction and other disorders of pituitary gland
0.608 0.392 0.000
M40.4 Other lordosis
0.607 0.392 0.000
M40.3 Flatback syndrome
0.607 0.392 0.000
M40.1 Other secondary kyphosis
0.607 0.392 0.000
M40.0 Postural kyphosis
0.607 0.392 0.000
H17 Corneal scars and opacities
0.607 0.393 0.000
H30.2 Posterior cyclitis
0.607 0.393 0.000
B27.9 Infectious mononucleosis, unspecified
0.604 0.396 0.000
G32.8 Other specified degenerative disorders of nervous system in diseases classified elsewhere
0.603 0.397 0.000
B23 Human immunodeficiency virus [HIV] disease resulting in other conditions
0.603 0.397 0.000
M35.3 Polymyalgia rheumatica
0.601 0.399 0.000
B33 Other viral diseases, not elsewhere classified
0.600 0.400 0.000
D84.1 Defects in the complement system
0.600 0.400 0.000
B37 Candidiasis
0.600 0.400 0.000
E51.2 Wernicke's encephalopathy
0.599 0.401 0.000
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot
0.598 0.402 0.000
M60.95 Myositis, unspecified (Pelvic region and thigh)
0.597 0.403 0.000
K90.8 Other intestinal malabsorption
0.596 0.404 0.000
M40.25 Other and unspecified kyphosis (Thoracolumbar region)
0.596 0.404 0.000
D74 Methaemoglobinaemia
0.595 0.405 0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.595 0.405 0.000
D71 Functional disorders of polymorphonuclear neutrophils
0.595 0.405 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.594 0.405 0.000
E24.3 Ectopic ACTH syndrome
0.594 0.405 0.000
E24.1 Nelson's syndrome
0.594 0.405 0.000
E31.9 Polyglandular dysfunction, unspecified
0.593 0.407 0.000
E31.8 Other polyglandular dysfunction
0.593 0.407 0.000
E31.1 Polyglandular hyperfunction
0.593 0.407 0.000
M40.22 Other and unspecified kyphosis (Cervical region)
0.593 0.407 0.000
H31.3 Choroidal haemorrhage and rupture
0.593 0.407 0.000
M62.26 Ischaemic infarction of muscle (Lower leg)
0.593 0.407 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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