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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs9469913
log Bayes Factor = 16.491
Chromosome 6   position 34,827,085  (GRCh37) Explore rs9469913 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter VII Diseases of the eye and adnexa
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XX External causes of morbidity and mortality
1.000 0.000 0.000
M05-M14 Inflammatory polyarthropathies
1.000 0.000 0.000
M50-M54 Other dorsopathies
0.999 0.001 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.999 0.001 0.000
M06 Other rheumatoid arthritis
0.999 0.001 0.000
M06.9 Rheumatoid arthritis, unspecified
0.998 0.002 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.997 0.003 0.000
Chapter XXI Factors influencing health status and contact with health services
0.996 0.004 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.995 0.005 0.000
M70-M79 Other soft tissue disorders
0.994 0.006 0.000
M54 Dorsalgia
0.994 0.006 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.992 0.008 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.992 0.008 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.992 0.008 0.000
M54.2 Cervicalgia
0.991 0.009 0.000
Z95 Presence of cardiac and vascular implants and grafts
0.990 0.010 0.000
H01 Other inflammation of eyelid
0.990 0.010 0.000
E65-E68 Obesity and other hyperalimentation
0.990 0.010 0.000
H55-H59 Other disorders of eye and adnexa
0.990 0.010 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.989 0.011 0.000
Z95.5 Presence of coronary angioplasty implant and graft
0.989 0.011 0.000
E66 Obesity
0.989 0.011 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.988 0.012 0.000
M54.22 Cervicalgia (Cervical region)
0.988 0.012 0.000
M79.0 Rheumatism, unspecified
0.986 0.014 0.000
Z86.5 Personal history of other mental and behavioural disorders
0.986 0.014 0.000
Z86 Personal history of certain other diseases
0.986 0.014 0.000
M51 Other intervertebral disk disorders
0.985 0.015 0.000
E66.9 Obesity, unspecified
0.984 0.016 0.000
Z95.1 Presence of aortocoronary bypass graft
0.981 0.019 0.000
H57 Other disorders of eye and adnexa
0.980 0.020 0.000
H01.0 Blepharitis
0.978 0.022 0.000
M51.2 Other specified intervertebral disk displacement
0.977 0.023 0.000
H53-H54 Visual disturbances and blindness
0.976 0.024 0.000
M07 Psoriatic and enteropathic arthropathies
0.969 0.031 0.000
H54 Blindness and low vision
0.966 0.034 0.000
Z82 Family history of certain disabilities and chronic diseases leading to disablement
0.963 0.037 0.000
H10-H13 Disorders of conjunctiva
0.962 0.038 0.000
H04 Disorders of lachrymal system
0.959 0.041 0.000
Z99 Dependence on enabling machines and devices, not elsewhere classified
0.958 0.042 0.000
Z82.4 Family history of ischaemic heart disease and other diseases of the circulatory system
0.958 0.042 0.000
Z60 Problems related to social environment
0.957 0.043 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.954 0.046 0.000
I10 Essential (primary) hypertension
0.954 0.046 0.000
E20-E35 Disorders of other endocrine glands
0.952 0.048 0.000
Chapter IX Diseases of the circulatory system
0.951 0.049 0.000
I10-I15 Hypertensive diseases
0.950 0.050 0.000
H54.4 Blindness, one eye
0.950 0.050 0.000
H30-H36 Disorders of choroid and retina
0.949 0.051 0.000
M07.3 Other psoriatic arthropathies
0.948 0.052 0.000
Y48 Anaesthetics and therapeutic gases
0.947 0.053 0.000
Q00-Q07 Congenital malformations of the nervous system
0.946 0.054 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.944 0.056 0.000
M79.09 Rheumatism, unspecified (Site unspecified)
0.943 0.057 0.000
M79.00 Rheumatism, unspecified (Multiple sites)
0.941 0.059 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.941 0.059 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.936 0.064 0.000
H57.1 Ocular pain
0.936 0.064 0.000
Z86.4 Personal history of psychoactive substance abuse
0.935 0.065 0.000
M54.4 Lumbago with sciatica
0.927 0.073 0.000
E66.8 Other obesity
0.927 0.073 0.000
M79.6 Pain in limb
0.927 0.073 0.000
Y42.5 Other oestrogens and progestogens
0.926 0.074 0.000
M07.39 Other psoriatic arthropathies (Site unspecified)
0.926 0.074 0.000
H04.1 Other disorders of lachrymal gland
0.923 0.077 0.000
I74 Arterial embolism and thrombosis
0.920 0.080 0.000
H35 Other retinal disorders
0.915 0.085 0.000
Z60.2 Living alone
0.914 0.086 0.000
Z99.8 Dependence on other enabling machines and devices
0.913 0.087 0.000
Z99.3 Dependence on wheelchair
0.912 0.088 0.000
Chapter VIII Diseases of the ear and mastoid process
0.910 0.090 0.000
H11 Other disorders of conjunctiva
0.908 0.092 0.000
M54.46 Lumbago with sciatica (Lumbar region)
0.907 0.093 0.000
Z59 Problems related to housing and economic circumstances
0.906 0.094 0.000
Z89 Acquired absence of limb
0.904 0.096 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.903 0.097 0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified
0.902 0.098 0.000
H57.8 Other specified disorders of eye and adnexa
0.902 0.098 0.000
M79.66 Pain in limb (Lower leg)
0.898 0.102 0.000
Chapter XXII Codes for special purposes
0.896 0.104 0.000
M65-M68 Disorders of synovium and tendon
0.885 0.115 0.000
H65-H75 Diseases of middle ear and mastoid
0.884 0.116 0.000
H11.3 Conjunctival haemorrhage
0.881 0.119 0.000
M13 Other arthritis
0.881 0.119 0.000
I74.5 Embolism and thrombosis of iliac artery
0.878 0.122 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.876 0.124 0.000
Q05 Spina bifida
0.876 0.124 0.000
X49 Accidental poisoning by and exposure to other and unspecified chemicals and noxious substances
0.871 0.128 0.000
I71 Aortic aneurysm and dissection
0.870 0.130 0.000
M51.0 Lumbar and other intervertebral disk disorders with myelopathy
0.867 0.133 0.000
Q80-Q89 Other congenital malformations
0.861 0.139 0.000
H40-H42 Glaucoma
0.859 0.141 0.000
N81.1 Cystocele
0.859 0.141 0.000
H74 Other disorders of middle ear and mastoid
0.859 0.141 0.000
Z86.1 Personal history of infectious and parasitic diseases
0.858 0.142 0.000
Z58 Problems related to physical environment
0.856 0.144 0.000
Z86.2 Personal history of diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.854 0.146 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.854 0.146 0.000
N81 Female genital prolapse
0.853 0.147 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.852 0.148 0.000
N81.8 Other female genital prolapse
0.850 0.150 0.000
M79.5 Residual foreign body in soft tissue
0.849 0.151 0.000
Y52 Agents primarily affecting the cardiovascular system
0.847 0.153 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.845 0.155 0.000
M05 Seropositive rheumatoid arthritis
0.843 0.157 0.000
Y48.3 Local anaesthetics
0.842 0.158 0.000
M67 Other disorders of synovium and tendon
0.841 0.159 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.841 0.159 0.000
M60-M63 Disorders of muscles
0.839 0.161 0.000
M91-M94 Chondropathies
0.838 0.162 0.000
V20-V29 Motorcycle rider injured in transport accident
0.836 0.164 0.000
E24 Cushing's syndrome
0.835 0.165 0.000
Y00-Y09 Assault
0.831 0.169 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.831 0.169 0.000
N81.6 Rectocele
0.829 0.171 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.825 0.175 0.000
Q60-Q64 Congenital malformations of the urinary system
0.824 0.176 0.000
W50-W64 Exposure to animate mechanical forces
0.824 0.176 0.000
Y48.2 Other and unspecified general anaesthetics
0.822 0.178 0.000
M79.08 Rheumatism, unspecified (Other)
0.822 0.178 0.000
Q07 Other congenital malformations of nervous system
0.820 0.180 0.000
X49.9 Unspecified place
0.820 0.180 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.819 0.181 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.818 0.182 0.000
M79.2 Neuralgia and neuritis, unspecified
0.818 0.182 0.000
H71 Cholesteatoma of middle ear
0.817 0.183 0.000
M06.3 Rheumatoid nodule
0.814 0.186 0.000
H35.8 Other specified retinal disorders
0.814 0.186 0.000
Z59.8 Other problems relating to housing and economic circumstances
0.810 0.190 0.000
M80-M85 Disorders of bone density and structure
0.809 0.191 0.000
H43-H45 Disorders of vitreous body and globe
0.808 0.192 0.000
H35.6 Retinal haemorrhage
0.807 0.193 0.000
M54.23 Cervicalgia (Cervicothoracic region)
0.806 0.194 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.803 0.197 0.000
Z64 Problems related to certain psychosocial circumstances
0.803 0.197 0.000
H35.0 Background retinopathy and retinal vascular changes
0.802 0.198 0.000
H54.7 Unspecified visual loss
0.801 0.199 0.000
I74.0 Embolism and thrombosis of abdominal aorta
0.799 0.201 0.000
H01.9 Inflammation of eyelid, unspecified
0.799 0.201 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.799 0.201 0.000
M79.61 Pain in limb (Shoulder region)
0.798 0.202 0.000
M76 Enthesopathies of lower limb, excluding foot
0.797 0.203 0.000
Y52.3 Coronary vasodilators, not elsewhere classified
0.797 0.203 0.000
Y58 Bacterial vaccines
0.794 0.206 0.000
M40-M43 Deforming dorsopathies
0.794 0.206 0.000
U89 Agent resistant to other and unspecified antibiotics
0.793 0.207 0.000
H59 Postprocedural disorders of eye and adnexa, not elsewhere classified
0.792 0.208 0.000
H01.1 Non-infectious dermatoses of eyelid
0.791 0.209 0.000
M86-M90 Other osteopathies
0.791 0.209 0.000
H74.8 Other specified disorders of middle ear and mastoid
0.791 0.209 0.000
I70 Atherosclerosis
0.789 0.211 0.000
Z95.8 Presence of other cardiac and vascular implants and grafts
0.788 0.212 0.000
Y51.9 Other and unspecified drugs primarily affecting the autonomic nervous system
0.787 0.213 0.000
M79.1 Myalgia
0.787 0.213 0.000
Y57 Other and unspecified drugs and medicaments
0.785 0.215 0.000
Z82.2 Family history of deafness and hearing loss
0.784 0.216 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.783 0.217 0.000
H33 Retinal detachments and breaks
0.783 0.217 0.000
H57.9 Disorder of eye and adnexa, unspecified
0.782 0.218 0.000
E65 Localised adiposity
0.782 0.218 0.000
V01-V09 Pedestrian injured in transport accident
0.781 0.219 0.000
H13 Disorders of conjunctiva in diseases classified elsewhere
0.780 0.220 0.000
H04.8 Other disorders of lachrymal system
0.778 0.222 0.000
H04.9 Disorder of lachrymal system, unspecified
0.778 0.222 0.000
W75-W84 Other accidental threats to breathing
0.777 0.222 0.000
H04.2 Epiphora
0.777 0.223 0.000
Q05.9 Spina bifida, unspecified
0.775 0.225 0.000
W20-W49 Exposure to inanimate mechanical forces
0.775 0.225 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.774 0.226 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.774 0.226 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.772 0.228 0.000
M07.30 Other psoriatic arthropathies (Multiple sites)
0.771 0.229 0.000
E28 Ovarian dysfunction
0.771 0.229 0.000
H01.8 Other specified inflammation of eyelid
0.769 0.231 0.000
E21.0 Primary hyperparathyroidism
0.768 0.232 0.000
Z95.4 Presence of other heart-valve replacement
0.767 0.233 0.000
I11 Hypertensive heart disease
0.766 0.234 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.765 0.235 0.000
X43 Accidental poisoning by and exposure to other drugs acting on the autonomic nervous system
0.765 0.235 0.000
H54.2 Low vision, both eyes
0.764 0.236 0.000
Z60.9 Problem related to social environment, unspecified
0.764 0.236 0.000
Z63 Other problems related to primary support group, including family circumstances
0.764 0.236 0.000
M54.8 Other dorsalgia
0.763 0.237 0.000
V98-V99 Other and unspecified transport accidents
0.763 0.237 0.000
M79.68 Pain in limb (Other)
0.760 0.240 0.000
M81 Osteoporosis without pathological fracture
0.759 0.241 0.000
H74.0 Tympanosclerosis
0.759 0.241 0.000
E26 Hyperaldosteronism
0.759 0.241 0.000
H40 Glaucoma
0.758 0.242 0.000
X47 Accidental poisoning by and exposure to other gases and vapours
0.758 0.242 0.000
H54.9 Unspecified visual impairment (binocular)
0.758 0.242 0.000
Z74 Problems related to care-provider dependency
0.758 0.242 0.000
Z58.8 Other problems related to physical environment
0.757 0.243 0.000
Z60.8 Other problems related to social environment
0.756 0.244 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.756 0.244 0.000
H40.2 Primary angle-closure glaucoma
0.756 0.244 0.000
H10 Conjunctivitis
0.753 0.247 0.000
H57.0 Anomalies of pupillary function
0.753 0.247 0.000
I73 Other peripheral vascular diseases
0.752 0.248 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.751 0.249 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.751 0.249 0.000
Q12 Congenital lens malformations
0.750 0.250 0.000
M67.8 Other specified disorders of synovium and tendon
0.750 0.250 0.000
E40-E46 Malnutrition
0.749 0.251 0.000
H31 Other disorders of choroid
0.749 0.251 0.000
Z59.0 Homelessness
0.748 0.252 0.000
X10-X19 Contact with heat and hot substances
0.748 0.252 0.000
Y42.4 Oral contraceptives
0.748 0.252 0.000
I74.9 Embolism and thrombosis of unspecified artery
0.748 0.252 0.000
E29 Testicular dysfunction
0.746 0.254 0.000
Y48.4 Anaesthetic, unspecified
0.745 0.255 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.745 0.255 0.000
Z89.0 Acquired absence of finger(s) [including thumb], unilateral
0.744 0.256 0.000
M06.0 Seronegative rheumatoid arthritis
0.744 0.256 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.743 0.257 0.000
X20-X29 Contact with venomous animals and plants
0.740 0.260 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.740 0.260 0.000
V90-V94 Water transport accidents
0.738 0.262 0.000
Y42.2 Antithyroid drugs
0.738 0.262 0.000
Y65 Other misadventures during surgical and medical care
0.738 0.262 0.000
H04.4 Chronic inflammation of lachrymal passages
0.738 0.262 0.000
X50-X57 Overexertion, travel and privation
0.738 0.262 0.000
Q89 Other congenital malformations, not elsewhere classified
0.737 0.263 0.000
U88 Agent resistant to multiple antibiotics
0.737 0.263 0.000
M54.3 Sciatica
0.737 0.263 0.000
M79.7 Fibromyalgia
0.733 0.267 0.000
V95-V97 Air and space transport accidents
0.733 0.267 0.000
H58 Other disorders of eye and adnexa in diseases classified elsewhere
0.733 0.267 0.000
H70 Mastoiditis and related conditions
0.733 0.267 0.000
N81.9 Female genital prolapse, unspecified
0.732 0.268 0.000
Z89.2 Acquired absence of upper limb above wrist
0.731 0.268 0.000
M07.34 Other psoriatic arthropathies (Hand)
0.731 0.269 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.731 0.269 0.000
Z83 Family history of other specific disorders
0.730 0.270 0.000
Q85 Phakomatoses, not elsewhere classified
0.730 0.270 0.000
Q07.0 Arnold-Chiari syndrome
0.730 0.270 0.000
M94 Other disorders of cartilage
0.730 0.270 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.729 0.271 0.000
M72 Fibroblastic disorders
0.729 0.271 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.728 0.272 0.000
M71 Other bursopathies
0.728 0.272 0.000
M54.29 Cervicalgia-Site unspe
0.726 0.274 0.000
E20 Hypoparathyroidism
0.725 0.275 0.000
M67.0 Short Achilles tendon (acquired)
0.725 0.275 0.000
H11.8 Other specified disorders of conjunctiva
0.724 0.276 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.723 0.277 0.000
E34 Other endocrine disorders
0.722 0.278 0.000
M13.9 Arthritis, unspecified
0.721 0.279 0.000
M53 Other dorsopathies, not elsewhere classified
0.719 0.281 0.000
M79.65 Pain in limb (Pelvic region and thigh)
0.719 0.281 0.000
H33.5 Other retinal detachments
0.718 0.282 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.718 0.282 0.000
V70-V79 Bus occupant injured in transport accident
0.718 0.282 0.000
Q05.7 Lumbar spina bifida without hydrocephalus
0.717 0.283 0.000
I71.0 Dissection of aorta [any part]
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.717 0.283 0.000
M08 Juvenile arthritis
0.717 0.283 0.000
Y35-Y36 Legal intervention and operations of war
0.717 0.283 0.000
Y10-Y34 Event of undetermined intent
0.717 0.283 0.000
X85-X99 Assault
0.717 0.283 0.000
X30-X39 Exposure to forces of nature
0.717 0.283 0.000
W65-W74 Accidental drowning and submersion
0.717 0.283 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.717 0.283 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.717 0.283 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.717 0.283 0.000
M13.8 Other specified arthritis
0.717 0.283 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.716 0.284 0.000
M06.8 Other specified rheumatoid arthritis
0.716 0.284 0.000
M06.2 Rheumatoid bursitis
0.716 0.284 0.000
M06.1 Adult-onset Still's disease
0.716 0.284 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.714 0.286 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.713 0.287 0.000
M54.0 Panniculitis affecting regions of neck and back
0.713 0.287 0.000
M13.0 Polyarthritis, unspecified
0.713 0.287 0.000
Z89.9 Acquired absence of limb, unspecified
0.712 0.288 0.000
Q35-Q37 Cleft lip and cleft palate
0.711 0.289 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.711 0.289 0.000
M79.3 Panniculitis, unspecified
0.711 0.289 0.000
M54.28 Cervicalgia-Sacral/sacrococ
0.711 0.289 0.000
M54.27 Cervicalgia-Lumbosacral
0.711 0.289 0.000
M54.26 Cervicalgia-Lumbar
0.711 0.289 0.000
M54.25 Cervicalgia-Thoracolumbar
0.711 0.289 0.000
M54.24 Cervicalgia-Thoracic
0.711 0.289 0.000
M54.21 Cervicalgia (Occipito-atlanto-axial region)
0.711 0.289 0.000
M54.20 Cervicalgia-Mult site
0.711 0.289 0.000
Z56 Problems related to employment and unemployment
0.710 0.289 0.000
E67 Other hyperalimentation
0.710 0.290 0.000
E68 Sequelae of hyperalimentation
0.710 0.290 0.000
Y59 Other and unspecified vaccines and biological substances
0.710 0.290 0.000
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.709 0.291 0.000
M85 Other disorders of bone density and structure
0.709 0.291 0.000
Q61 Cystic kidney disease
0.709 0.291 0.000
E66.1 Drug-induced obesity
0.709 0.291 0.000
Z65 Problems related to other psychosocial circumstances
0.709 0.291 0.000
Z62 Other problems related to upbringing
0.709 0.291 0.000
Z61 Problems related to negative life events in childhood
0.709 0.291 0.000
Z55 Problems related to education and literacy
0.709 0.291 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.709 0.291 0.000
X00-X09 Exposure to smoke, fire and flames
0.707 0.292 0.000
M79.07 Rheumatism, unspecified (Ankle and foot)
0.707 0.293 0.000
M79.06 Rheumatism, unspecified (Lower leg)
0.707 0.293 0.000
M79.05 Rheumatism, unspecified (Pelvic region and thigh)
0.707 0.293 0.000
M79.04 Rheumatism, unspecified (Hand)
0.707 0.293 0.000
M79.03 Rheumatism, unspecified (Forearm)
0.707 0.293 0.000
M79.02 Rheumatism, unspecified (Upper arm)
0.707 0.293 0.000
M79.01 Rheumatism, unspecified (Shoulder region)
0.707 0.293 0.000
M51.3 Other specified intervertebral disk degeneration
0.706 0.293 0.000
M51.1 Lumbar and other intervertebral disk disorders with radiculopathy
0.706 0.293 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.706 0.294 0.000
H30 Chorioretinal inflammation
0.705 0.295 0.000
X45 Accidental poisoning by and exposure to alcohol
0.705 0.295 0.000
M12 Other specific arthropathies
0.704 0.296 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.704 0.296 0.000
Z82.5 Family history of asthma and other chronic lower respiratory diseases
0.703 0.297 0.000
U89.8 Agent resistant to other single specified antibiotic
0.703 0.297 0.000
E27 Other disorders of adrenal gland
0.702 0.298 0.000
Y85 Sequelae of transport accidents
0.702 0.298 0.000
Z89.5 Acquired absence of leg at or below knee
0.701 0.299 0.000
Y44 Agents primarily affecting blood constituents
0.700 0.300 0.000
E24.0 Pituitary-dependent Cushing's disease
0.699 0.301 0.000
H04.3 Acute and unspecified inflammation of lachrymal passages
0.697 0.303 0.000
M62 Other disorders of muscle
0.697 0.303 0.000
E28.3 Primary ovarian failure
0.696 0.304 0.000
M07.6 Other enteropathic arthropathies
0.695 0.305 0.000
M07.5 Arthropathy in ulcerative colitis
0.695 0.305 0.000
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.695 0.305 0.000
M07.2 Psoriatic spondylitis
0.695 0.305 0.000
M07.1 Arthritis mutilans
0.695 0.305 0.000
M07.0 Distal interphalangeal psoriatic arthropathy
0.695 0.305 0.000
Z89.7 Acquired absence of both lower limbs [any level, except toes alone]
0.695 0.305 0.000
Y86 Sequelae of other accidents
0.695 0.305 0.000
H54.3 Unqualified visual loss, both eyes
0.693 0.307 0.000
H54.1 Blindness, one eye, low vision, other eye
0.693 0.307 0.000
H54.6 Unqualified visual loss, one eye
0.693 0.307 0.000
Y46.6 Other and unspecified antiepileptics
0.692 0.307 0.000
M51.4 Schmorl's nodes
0.692 0.308 0.000
M54.6 Pain in thoracic spine
0.692 0.308 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.691 0.309 0.000
H33.4 Traction detachment of retina
0.690 0.310 0.000
M79.54 Residual foreign body in soft tissue (Hand)
0.690 0.310 0.000
Z82.8 Family history of other disabilities and chronic diseases leading to disablement, not elsewhere classified
0.690 0.310 0.000
Z82.1 Family history of blindness and visual loss
0.690 0.310 0.000
I00-I02 Acute rheumatic fever
0.690 0.310 0.000
H74.1 Adhesive middle ear disease
0.690 0.310 0.000
H35.2 Other proliferative retinopathy
0.690 0.310 0.000
M77 Other enthesopathies
0.689 0.311 0.000
M67.1 Other contracture of tendon (sheath)
0.689 0.311 0.000
H44 Disorders of globe
0.688 0.312 0.000
H59.9 Postprocedural disorder of eye and adnexa, unspecified
0.688 0.312 0.000
Q50-Q56 Congenital malformations of genital organs
0.687 0.312 0.000
H04.6 Other changes in lachrymal passages
0.687 0.313 0.000
H04.0 Dacryoadenitis
0.687 0.313 0.000
Z99.9 Dependence on unspecified enabling machine and device
0.687 0.313 0.000
Z99.4 Dependence on artificial heart
0.687 0.313 0.000
Z99.0 Dependence on aspirator
0.687 0.313 0.000
Z60.5 Target of perceived adverse discrimination and persecution
0.686 0.314 0.000
Z60.4 Social exclusion and rejection
0.686 0.314 0.000
Z60.3 Acculturation difficulty
0.686 0.314 0.000
Z60.1 Atypical parenting situation
0.686 0.314 0.000
Z60.0 Problems of adjustment to life-cycle transitions
0.686 0.314 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.686 0.314 0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.686 0.314 0.000
M81.4 Drug-induced osteoporosis
0.685 0.315 0.000
M79.69 Pain in limb (Site unspecified)
0.684 0.316 0.000
M10 Gout
0.684 0.316 0.000
M11 Other crystal arthropathies
0.684 0.316 0.000
Y51.8 Centrally acting and adrenergic-neuron-blocking agents, not elsewhere classified
0.684 0.316 0.000
Y51.6 @-Adrenoreceptor antagonists, not elsewhere classified
0.684 0.316 0.000
Y51.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified
0.684 0.316 0.000
Y51.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified
0.684 0.316 0.000
Y51.3 Other parasympatholytics [anticholinergics and antimuscarinics] and spasmolytics, not elsewhere classified
0.684 0.316 0.000
Y51.2 Ganglionic blocking drugs, not elsewhere classified
0.684 0.316 0.000
Y51.1 Other parasympathomimetics [cholinergics]
0.684 0.316 0.000
Y51.0 Anticholinesterase agents
0.684 0.316 0.000
E24.8 Other Cushing's syndrome
0.684 0.316 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.683 0.317 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.683 0.317 0.000
E32 Diseases of thymus
0.683 0.317 0.000
E31 Polyglandular dysfunction
0.683 0.317 0.000
E30 Disorders of puberty, not elsewhere classified
0.683 0.317 0.000
E25 Adrenogenital disorders
0.683 0.317 0.000
U89.9 Agent resistant to unspecified antibiotic
0.683 0.317 0.000
Y52.1 Calcium-channel blockers
0.682 0.318 0.000
I13 Hypertensive heart and renal disease
0.681 0.319 0.000
I73.9 Peripheral vascular disease, unspecified
0.681 0.319 0.000
M06.4 Inflammatory polyarthropathy
0.681 0.319 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.680 0.319 0.000
Q05.4 Unspecified spina bifida with hydrocephalus
0.680 0.320 0.000
M43 Other deforming dorsopathies
0.680 0.320 0.000
M07.38 Other psoriatic arthropathies (Other)
0.679 0.320 0.000
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.679 0.320 0.000
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.679 0.320 0.000
M07.33 Other psoriatic arthropathies (Forearm)
0.679 0.320 0.000
M07.32 Other psoriatic arthropathies (Upper arm)
0.679 0.320 0.000
M07.31 Other psoriatic arthropathies (Shoulder region)
0.679 0.320 0.000
Y48.5 Therapeutic gases
0.679 0.321 0.000
Y48.1 Parenteral anaesthetics
0.679 0.321 0.000
Y48.0 Inhaled anaesthetics
0.679 0.321 0.000
X60-X84 Intentional self-harm
0.679 0.321 0.000
Z89.6 Acquired absence of leg above knee
0.679 0.321 0.000
Q06 Other congenital malformations of spinal cord
0.678 0.322 0.000
Q04 Other congenital malformations of brain
0.678 0.322 0.000
Q03 Congenital hydrocephalus
0.678 0.322 0.000
Q01 Encephalocele
0.678 0.322 0.000
Q00 Anencephaly and similar malformations
0.678 0.322 0.000
Q02 Microcephaly
0.678 0.322 0.000
W57 Bitten or stung by non-venomous insect and other non-venomous arthropods
0.678 0.322 0.000
X48 Accidental poisoning by and exposure to pesticides
0.677 0.323 0.000
X46 Accidental poisoning by and exposure to organic solvents and halogenated hydrocarbons and their vapours
0.677 0.323 0.000
X44 Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
0.677 0.323 0.000
X42 Accidental poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified
0.677 0.323 0.000
X40 Accidental poisoning by and exposure to nonopioid analgesics, antipyretics and antirheumatics
0.677 0.323 0.000
Y42.9 Other and unspecified hormone antagonists
0.674 0.325 0.000
Y42.1 Thyroid hormones and substitutes
0.674 0.325 0.000
M79.53 Residual foreign body in soft tissue (Forearm)
0.674 0.326 0.000
V23 Motorcycle rider injured in collision with car, pick-up truck or van
0.674 0.326 0.000
M05.1 Rheumatoid lung disease
0.673 0.327 0.000
M79.26 Neuralgia and neuritis, unspecified (Lower leg)
0.673 0.327 0.000
Y00 Assault by blunt object
0.672 0.328 0.000
Q17 Other congenital malformations of ear
0.672 0.328 0.000
Y52.0 Cardiac-stimulant glycosides and drugs of similar action
0.672 0.328 0.000
Z64.0 Problems related to unwanted pregnancy
0.671 0.329 0.000
H69 Other disorders of Eustachian tube
0.670 0.329 0.000
E66.0 Obesity due to excess calories
0.670 0.330 0.000
H55 Nystagmus and other irregular eye movements
0.670 0.330 0.000
H90-H95 Other disorders of ear
0.670 0.330 0.000
Y46.2 Hydantoin derivatives
0.669 0.331 0.000
M54.37 Sciatica (Lumbosacral region)
0.669 0.331 0.000
I70.0 Atherosclerosis of aorta
0.667 0.332 0.000
I11.9 Hypertensive heart disease without (congestive) heart failure
0.667 0.333 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.667 0.333 0.000
Z74.8 Other problems related to care-provider dependency
0.666 0.334 0.000
M54.48 Lumbago with sciatica (Sacral and sacrococcygeal region)
0.665 0.335 0.000
M54.45 Lumbago with sciatica (Thoracolumbar region)
0.665 0.335 0.000
M54.44 Lumbago with sciatica-Thoracic
0.665 0.335 0.000
M54.43 Lumbago with sciatica-Cervicothoracic
0.665 0.335 0.000
M54.42 Lumbago with sciatica-Cervical
0.665 0.335 0.000
M54.41 Lumbago with sciatica-Occipit-atl-axl
0.665 0.335 0.000
M54.40 Lumbago with sciatica (Multiple sites in spine)
0.665 0.335 0.000
H54.5 Low vision, one eye
0.664 0.336 0.000
Y42.8 Other and unspecified hormones and their synthetic substitutes
0.664 0.336 0.000
Y55.6 Antiasthmatics, not elsewhere classified
0.663 0.337 0.000
Z84 Family history of other conditions
0.663 0.337 0.000
E50-E64 Other nutritional deficiencies
0.663 0.337 0.000
Z63.4 Disappearance and death of family member
0.663 0.337 0.000
Q18 Other congenital malformations of face and neck
0.662 0.337 0.000
Y65.8 Other specified misadventures during surgical and medical care
0.662 0.338 0.000
M13.95 Arthritis, unspecified (Pelvic region and thigh)
0.661 0.339 0.000
H73 Other disorders of tympanic membrane
0.661 0.339 0.000
H35.9 Retinal disorder, unspecified
0.661 0.339 0.000
Z74.2 Need for assistance at home and no other household member able to render care
0.660 0.340 0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.660 0.340 0.000
V10-V19 Pedal cyclist injured in transport accident
0.659 0.341 0.000
Q12.0 Congenital cataract
0.659 0.341 0.000
H35.3 Degeneration of macula and posterior pole
0.658 0.342 0.000
H35.1 Retinopathy of prematurity
0.656 0.344 0.000
M79.57 Residual foreign body in soft tissue (Ankle and foot)
0.656 0.344 0.000
E34.0 Carcinoid syndrome
0.655 0.345 0.000
H35.4 Peripheral retinal degeneration
0.655 0.345 0.000
H74.9 Disorder of middle ear and mastoid, unspecified
0.653 0.347 0.000
Y04 Assault by bodily force
0.653 0.347 0.000
M06.30 Rheumatoid nodule (Multiple sites)
0.652 0.348 0.000
Q64 Other congenital malformations of urinary system
0.652 0.348 0.000
H11.2 Conjunctival scars
0.651 0.349 0.000
W00-W19 Falls
0.651 0.349 0.000
I74.8 Embolism and thrombosis of other arteries
0.650 0.349 0.000
Y57.9 Drug or medicament, unspecified
0.650 0.350 0.000
Z98 Other postsurgical states
0.650 0.350 0.000
H13.3 Ocular pemphigoid
0.650 0.350 0.000
Z59.9 Problem relating to housing and economic circumstances, unspecified
0.649 0.350 0.000
Z59.7 Insufficient social insurance and welfare support
0.649 0.350 0.000
Z59.6 Low income
0.649 0.350 0.000
Z59.5 Extreme poverty
0.649 0.350 0.000
Z59.4 Lack of adequate food
0.649 0.350 0.000
Z59.3 Problems related to living in residential institution
0.649 0.350 0.000
Z59.2 Discord with neighbours, lodgers and landlord
0.649 0.350 0.000
Z59.1 Inadequate housing
0.649 0.350 0.000
Z21 Asymptomatic human immunodeficiency virus [HIV] infection status
0.649 0.351 0.000
H10.9 Conjunctivitis, unspecified
0.649 0.351 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.648 0.352 0.000
H54.0 Blindness, both eyes
0.648 0.352 0.000
M89 Other disorders of bone
0.648 0.352 0.000
Z89.8 Acquired absence of upper and lower limbs [any level]
0.648 0.352 0.000
Z89.3 Acquired absence of both upper limbs [any level]
0.648 0.352 0.000
Z89.1 Acquired absence of hand and wrist
0.648 0.352 0.000
Q89.2 Congenital malformations of other endocrine glands
0.648 0.352 0.000
Y58.0 BCG vaccine
0.648 0.352 0.000
E24.9 Cushing's syndrome, unspecified
0.647 0.352 0.000
H11.0 Pterygium
0.647 0.353 0.000
M76.0 Gluteal tendinitis
0.647 0.353 0.000
Q10 Congenital malformations of eyelid, lachrymal apparatus and orbit
0.646 0.353 0.000
M14 Arthropathies in other diseases classified elsewhere
0.646 0.354 0.000
M60 Myositis
0.645 0.354 0.000
H74.3 Other acquired abnormalities of ear ossicles
0.644 0.356 0.000
M85.8 Other specified disorders of bone density and structure
0.644 0.356 0.000
W50 Hit, struck, kicked, twisted, bitten or scratched by another person
0.643 0.357 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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