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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs958025
log Bayes Factor = 9.05584
Chromosome 15   position 78,759,348  (GRCh37) Explore rs958025 on Ensembl!
Variant rs958025 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I60-I69 Cerebrovascular diseases
0.000 0.000 1.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.001 0.999
I69 Sequelae of cerebrovascular disease
0.000 0.001 0.999
I71 Aortic aneurysm and dissection
0.000 0.001 0.999
J44.9 Chronic obstructive pulmonary disease, unspecified
0.000 0.001 0.999
J44 Other chronic obstructive pulmonary disease
0.000 0.002 0.998
I67 Other cerebrovascular diseases
0.000 0.006 0.994
I64 Stroke, not specified as haemorrhage or infarction
0.000 0.008 0.992
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.000 0.009 0.991
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.000 0.009 0.991
I60 Subarachnoid haemorrhage
0.000 0.014 0.986
I73 Other peripheral vascular diseases
0.000 0.015 0.985
I67.9 Cerebrovascular disease, unspecified
0.000 0.016 0.984
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.000 0.020 0.980
I73.9 Peripheral vascular disease, unspecified
0.000 0.022 0.978
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.000 0.028 0.972
I70 Atherosclerosis
0.000 0.036 0.964
J40-J47 Chronic lower respiratory diseases
0.000 0.043 0.957
J43 Emphysema
0.000 0.047 0.953
J43.9 Emphysema, unspecified
0.000 0.049 0.951
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.000 0.055 0.945
J42 Unspecified chronic bronchitis
0.000 0.058 0.942
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.065 0.935
I60.8 Other subarachnoid haemorrhage
0.000 0.065 0.935
I77 Other disorders of arteries and arterioles
0.000 0.066 0.934
I67.1 Cerebral aneurysm, nonruptured
0.000 0.071 0.929
I69.0 Sequelae of subarachnoid haemorrhage
0.000 0.071 0.929
I69.3 Sequelae of cerebral infarction
0.000 0.072 0.928
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.000 0.082 0.918
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.105 0.895
Chapter IX Diseases of the circulatory system
0.000 0.110 0.890
I71.3 Abdominal aortic aneurysm, ruptured
0.000 0.123 0.877
I60.3 Subarachnoid haemorrhage from posterior communicating artery
0.000 0.151 0.849
I74 Arterial embolism and thrombosis
0.000 0.152 0.848
I77.0 Arteriovenous fistula, acquired
0.000 0.159 0.841
I60.1 Subarachnoid haemorrhage from middle cerebral artery
0.000 0.160 0.840
I69.2 Sequelae of other nontraumatic intracranial haemorrhage
0.000 0.168 0.832
I69.1 Sequelae of intracerebral haemorrhage
0.000 0.183 0.817
I72 Other aneurysm
0.000 0.188 0.812
I60.2 Subarachnoid haemorrhage from anterior communicating artery
0.000 0.194 0.806
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.211 0.789
I60.9 Subarachnoid haemorrhage, unspecified
0.000 0.223 0.777
I70.0 Atherosclerosis of aorta
0.000 0.229 0.770
I67.8 Other specified cerebrovascular diseases
0.000 0.231 0.769
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.235 0.765
I73.0 Raynaud's syndrome
0.000 0.236 0.764
I68 Cerebrovascular disorders in diseases classified elsewhere
0.000 0.242 0.758
I60.7 Subarachnoid haemorrhage from intracranial artery, unspecified
0.000 0.255 0.745
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.271 0.729
I71.0 Dissection of aorta [any part]
0.000 0.282 0.718
I71.8 Aortic aneurysm of unspecified site, ruptured
0.000 0.284 0.716
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.000 0.284 0.716
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.000 0.284 0.716
I71.1 Thoracic aortic aneurysm, ruptured
0.000 0.284 0.716
I67.7 Cerebral arteritis, not elsewhere classified
0.000 0.287 0.713
I67.6 Nonpyogenic thrombosis of intracranial venous system
0.000 0.287 0.713
I67.5 Moyamoya disease
0.000 0.287 0.713
I67.4 Hypertensive encephalopathy
0.000 0.287 0.713
I67.3 Progressive vascular leukoencephalopathy
0.000 0.287 0.713
I78 Diseases of capillaries
0.000 0.288 0.712
I77.2 Rupture of artery
0.000 0.292 0.708
I60.5 Subarachnoid haemorrhage from vertebral artery
0.000 0.293 0.707
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation
0.000 0.293 0.707
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.294 0.706
J43.2 Centrilobular emphysema
0.000 0.294 0.706
I77.1 Stricture of artery
0.000 0.296 0.704
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.000 0.297 0.703
I70.9 Generalised and unspecified atherosclerosis
0.000 0.309 0.691
I70.8 Atherosclerosis of other arteries
0.000 0.309 0.691
J41 Simple and mucopurulent chronic bronchitis
0.000 0.314 0.686
J43.1 Panlobular emphysema
0.000 0.317 0.683
J43.0 MacLeod's syndrome
0.000 0.317 0.683
I61 Intracerebral haemorrhage
0.000 0.320 0.680
I67.0 Dissection of cerebral arteries, nonruptured
0.000 0.323 0.677
I77.5 Necrosis of artery
0.000 0.330 0.670
I77.4 Coeliac artery compression syndrome
0.000 0.330 0.670
I60.4 Subarachnoid haemorrhage from basilar artery
0.000 0.334 0.666
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.343 0.657
I74.8 Embolism and thrombosis of other arteries
0.000 0.350 0.650
I72.8 Aneurysm of other specified arteries
0.000 0.352 0.648
I72.9 Aneurysm of unspecified site
0.000 0.355 0.645
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.000 0.357 0.643
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.362 0.638
I63 Cerebral infarction
0.000 0.366 0.634
I72.0 Aneurysm of carotid artery
0.000 0.367 0.632
I70.00 Atherosclerosis of aorta (without gangrene)
0.000 0.368 0.632
I70.1 Atherosclerosis of renal artery
0.000 0.374 0.626
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.000 0.377 0.623
I27 Other pulmonary heart diseases
0.000 0.377 0.623
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.380 0.620
I00-I02 Acute rheumatic fever
0.000 0.382 0.618
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.387 0.613
I72.4 Aneurysm of artery of lower extremity
0.000 0.387 0.612
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.000 0.390 0.610
I61.4 Intracerebral haemorrhage in cerebellum
0.000 0.396 0.604
I27.9 Pulmonary heart disease, unspecified
0.000 0.398 0.602
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.410 0.590
I61.1 Intracerebral haemorrhage in hemisphere, cortical
0.000 0.416 0.584
I68.0 Cerebral amyloid angiopathy
0.000 0.416 0.584
I72.6 Aneurysm and dissection of vertebral artery
0.000 0.418 0.582
I72.5 Aneurysm and dissection of other precerebral arteries
0.000 0.418 0.582
I72.1 Aneurysm of artery of upper extremity
0.000 0.418 0.582
J43.8 Other emphysema
0.000 0.418 0.582
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
0.000 0.419 0.581
I60.6 Subarachnoid haemorrhage from other intracranial arteries
0.000 0.424 0.576
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.434 0.566
I79.1 Aortitis in diseases classified elsewhere
0.000 0.434 0.566
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.434 0.566
I74.5 Embolism and thrombosis of iliac artery
0.000 0.443 0.557
I70.01 Atherosclerosis of aorta (with gangrene)
0.000 0.447 0.552
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.448 0.552
I77.3 Arterial fibromuscular dysplasia
0.000 0.448 0.552
I68.8 Other cerebrovascular disorders in diseases classified elsewhere
0.000 0.457 0.543
I68.2 Cerebral arteritis in other diseases classified elsewhere
0.000 0.457 0.543
I68.1 Cerebral arteritis in infectious and parasitic diseases classified elsewhere
0.000 0.457 0.543
I26 Pulmonary embolism
0.000 0.464 0.536
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.466 0.534
I72.3 Aneurysm of iliac artery
0.000 0.467 0.533
I66.9 Occlusion and stenosis of unspecified cerebral artery
0.000 0.480 0.520
I77.8 Other specified disorders of arteries and arterioles
0.000 0.482 0.518
I78.9 Disease of capillaries, unspecified
0.000 0.489 0.511
I73.8 Other specified peripheral vascular diseases
0.000 0.494 0.506
I63.0 Cerebral infarction due to thrombosis of precerebral arteries
0.000 0.495 0.505
I66.8 Occlusion and stenosis of other cerebral artery
0.000 0.496 0.504
I66.3 Occlusion and stenosis of cerebellar arteries
0.000 0.496 0.504
I66.2 Occlusion and stenosis of posterior cerebral artery
0.000 0.496 0.504
I66.1 Occlusion and stenosis of anterior cerebral artery
0.000 0.496 0.504
I72.2 Aneurysm of renal artery
0.000 0.500 0.500
I70.81 Atherosclerosis of other arteries (with gangrene)
0.000 0.504 0.495
I70.80 Atherosclerosis of other arteries (without gangrene)
0.000 0.504 0.495
I70.91 Generalized and unspecified atherosclerosis (with gangrene)
0.000 0.504 0.495
I70.90 Generalized and unspecified atherosclerosis (without gangrene)
0.000 0.504 0.495
I78.8 Other diseases of capillaries
0.000 0.507 0.493
J41.8 Mixed simple and mucopurulent chronic bronchitis
0.000 0.508 0.492
J41.1 Mucopurulent chronic bronchitis
0.000 0.508 0.492
J41.0 Simple chronic bronchitis
0.000 0.508 0.492
I28 Other diseases of pulmonary vessels
0.000 0.511 0.489
I66.4 Occlusion and stenosis of multiple and bilateral cerebral arteries
0.000 0.511 0.488
I66.0 Occlusion and stenosis of middle cerebral artery
0.000 0.512 0.488
I67.2 Cerebral atherosclerosis
0.000 0.523 0.477
I61.6 Intracerebral haemorrhage, multiple localised
0.000 0.523 0.477
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.000 0.526 0.474
I61.0 Intracerebral haemorrhage in hemisphere, subcortical
0.000 0.534 0.465
I61.8 Other intracerebral haemorrhage
0.000 0.540 0.460
I61.5 Intracerebral haemorrhage, intraventricular
0.000 0.542 0.457
J46 Status asthmaticus
0.000 0.543 0.457
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic
0.000 0.545 0.454
I63.1 Cerebral infarction due to embolism of precerebral arteries
0.000 0.545 0.454
I70.11 Atherosclerosis of renal artery (with gangrene)
0.000 0.551 0.449
I61.3 Intracerebral haemorrhage in brain stem
0.000 0.552 0.448
I27.8 Other specified pulmonary heart diseases
0.000 0.552 0.448
I62 Other nontraumatic intracranial haemorrhage
0.000 0.553 0.447
I27.1 Kyphoscoliotic heart disease
0.000 0.553 0.447
I02 Rheumatic chorea
0.000 0.557 0.443
I01 Rheumatic fever with heart involvement
0.000 0.557 0.443
J44.8 Other specified chronic obstructive pulmonary disease
0.000 0.558 0.442
I00 Rheumatic fever without mention of heart involvement
0.000 0.577 0.423
I26.0 Pulmonary embolism with mention of acute cor pulmonale
0.000 0.585 0.415
I63.3 Cerebral infarction due to thrombosis of cerebral arteries
0.000 0.586 0.413
I63.4 Cerebral infarction due to embolism of cerebral arteries
0.000 0.588 0.412
I63.9 Cerebral infarction, unspecified
0.000 0.602 0.398
I77.6 Arteritis, unspecified
0.000 0.606 0.394
I61.2 Intracerebral haemorrhage in hemisphere, unspecified
0.000 0.613 0.387
I70.10 Atherosclerosis of renal artery (without gangrene)
0.000 0.616 0.383
E11 Non-insulin-dependent diabetes mellitus
0.000 0.621 0.379
I27.0 Primary pulmonary hypertension
0.000 0.628 0.371
J40 Bronchitis, not specified as acute or chronic
0.000 0.630 0.369
E11.4 With neurological complications
0.000 0.633 0.367
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.000 0.638 0.362
I65.0 Occlusion and stenosis of vertebral artery
0.000 0.642 0.357
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
0.000 0.647 0.353
E11.5 With peripheral circulatory complications
0.000 0.649 0.351
I28.9 Disease of pulmonary vessels, unspecified
0.000 0.649 0.351
I28.1 Aneurysm of pulmonary artery
0.000 0.649 0.351
I28.0 Arteriovenous fistula of pulmonary vessels
0.000 0.649 0.351
E11.0 With coma
0.000 0.658 0.342
E11.3 With ophthalmic complications
0.000 0.658 0.342
I65.9 Occlusion and stenosis of unspecified precerebral artery
0.000 0.660 0.340
I65.8 Occlusion and stenosis of other precerebral artery
0.000 0.660 0.340
E11.8 With unspecified complications
0.000 0.665 0.335
E11.2 With renal complications
0.000 0.665 0.335
I78.1 Naevus, nonneoplastic
0.000 0.672 0.328
I05-I09 Chronic rheumatic heart diseases
0.000 0.674 0.326
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.682 0.318
I01.8 Other acute rheumatic heart disease
0.000 0.682 0.318
I01.2 Acute rheumatic myocarditis
0.000 0.682 0.318
I01.1 Acute rheumatic endocarditis
0.000 0.682 0.318
I01.0 Acute rheumatic pericarditis
0.000 0.682 0.318
I02.9 Rheumatic chorea without heart involvement
0.000 0.682 0.318
I02.0 Rheumatic chorea with heart involvement
0.000 0.682 0.318
I28.8 Other specified diseases of pulmonary vessels
0.000 0.683 0.317
I62.1 Nontraumatic extradural haemorrhage
0.000 0.685 0.315
E11.6 With other specified complications
0.000 0.690 0.310
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries
0.000 0.692 0.308
I62.9 Intracranial haemorrhage (nontraumatic), unspecified
0.000 0.696 0.303
E10-E14 Diabetes mellitus
0.000 0.703 0.297
E11.1 With ketoacidosis
0.000 0.706 0.294
I65.2 Occlusion and stenosis of carotid artery
0.000 0.720 0.280
I61.9 Intracerebral haemorrhage, unspecified
0.000 0.721 0.278
E11.7 With multiple complications
0.000 0.728 0.272
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.729 0.271
E14 Unspecified diabetes mellitus
0.000 0.732 0.268
I09 Other rheumatic heart diseases
0.000 0.737 0.263
E13 Other specified diabetes mellitus
0.000 0.741 0.259
E14.9 Without complications
0.000 0.745 0.255
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.254 0.746 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.250 0.750 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.247 0.753 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.245 0.755 0.000
I63.8 Other cerebral infarction
0.000 0.759 0.241
T43.2 Other and unspecified antidepressants
0.240 0.760 0.000
I65.1 Occlusion and stenosis of basilar artery
0.001 0.766 0.233
E13.9 Without complications
0.000 0.769 0.231
T42.4 Benzodiazepines
0.231 0.769 0.000
I09.9 Rheumatic heart disease, unspecified
0.000 0.782 0.218
I06 Rheumatic aortic valve diseases
0.000 0.783 0.216
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.215 0.785 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.213 0.787 0.000
E12 Malnutrition-related diabetes mellitus
0.000 0.787 0.213
J45 Asthma
0.000 0.790 0.210
E14.3 With ophthalmic complications
0.000 0.791 0.209
I07 Rheumatic tricuspid valve diseases
0.000 0.791 0.209
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.208 0.792 0.000
T42.0 Hydantoin derivatives
0.204 0.796 0.000
I05 Rheumatic mitral valve diseases
0.000 0.797 0.203
T43.0 Tricyclic and tetracyclic antidepressants
0.200 0.800 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.200 0.800 0.000
E14.1 With ketoacidosis
0.000 0.802 0.198
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.195 0.805 0.000
E14.8 With unspecified complications
0.000 0.807 0.193
E14.7 With multiple complications
0.000 0.807 0.192
E14.0 With coma
0.000 0.807 0.192
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.192 0.808 0.000
E14.4 With neurological complications
0.000 0.809 0.191
T43.3 Phenothiazine antipsychotics and neuroleptics
0.191 0.809 0.000
I09.8 Other specified rheumatic heart diseases
0.000 0.811 0.189
I09.2 Chronic rheumatic pericarditis
0.000 0.811 0.189
I09.1 Rheumatic diseases of endocardium, valve unspecified
0.000 0.811 0.189
I09.0 Rheumatic myocarditis
0.000 0.811 0.189
I98 Other disorders of circulatory system in diseases classified elsewhere
0.000 0.812 0.188
E10 Insulin-dependent diabetes mellitus
0.000 0.812 0.188
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.187 0.813 0.000
E13.8 With unspecified complications
0.000 0.814 0.185
E13.7 With multiple complications
0.000 0.814 0.185
E13.6 With other specified complications
0.000 0.814 0.185
E13.5 With peripheral circulatory complications
0.000 0.814 0.185
E13.4 With neurological complications
0.000 0.814 0.185
E13.3 With ophthalmic complications
0.000 0.814 0.185
E13.2 With renal complications
0.000 0.814 0.185
E13.1 With ketoacidosis
0.000 0.814 0.185
E13.0 With coma
0.000 0.814 0.185
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.185 0.815 0.000
E14.6 With other specified complications
0.000 0.816 0.184
T43.5 Other and unspecified antipsychotics and neuroleptics
0.184 0.816 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.182 0.818 0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.182 0.818 0.000
T42.5 Mixed antiepileptics, not elsewhere classified
0.182 0.818 0.000
T42.3 Barbiturates
0.182 0.818 0.000
T42.2 Succinimides and oxazolidinediones
0.182 0.818 0.000
T45.0 Antiallergic and antiemetic drugs
0.181 0.819 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.180 0.820 0.000
I27.2 Other secondary pulmonary hypertension
0.000 0.820 0.180
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.180 0.820 0.000
E10.1 With ketoacidosis
0.000 0.822 0.178
T41 Poisoning by anaesthetics and therapeutic gases
0.177 0.823 0.000
T43.9 Psychotropic drug, unspecified
0.176 0.824 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.176 0.824 0.000
T40.4 Other synthetic narcotics
0.176 0.824 0.000
E14.5 With peripheral circulatory complications
0.000 0.828 0.172
T45.1 Antineoplastic and immunosuppressive drugs
0.170 0.830 0.000
T40.6 Other and unspecified narcotics
0.169 0.831 0.000
I05.1 Rheumatic mitral insufficiency
0.000 0.832 0.168
T40.2 Other opioids
0.168 0.832 0.000
J92.0 Pleural plaque with presence of asbestos
0.000 0.835 0.165
T42.1 Iminostilbenes
0.165 0.835 0.000
T43.6 Psychostimulants with abuse potential
0.164 0.836 0.000
T45.2 Vitamins, not elsewhere classified
0.163 0.837 0.000
I10-I15 Hypertensive diseases
0.000 0.838 0.162
T36 Poisoning by systemic antibiotics
0.160 0.840 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.160 0.840 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.159 0.840 0.000
E14.2 Withrenal complications
0.000 0.841 0.158
T46.5 Other antihypertensive drugs, not elsewhere classified
0.158 0.842 0.000
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified
0.157 0.843 0.000
I06.9 Rheumatic aortic valve disease, unspecified
0.000 0.844 0.155
I06.8 Other rheumatic aortic valve diseases
0.000 0.844 0.155
I06.2 Rheumatic aortic stenosis with insufficiency
0.000 0.844 0.155
I06.1 Rheumatic aortic insufficiency
0.000 0.844 0.155
T46.3 Coronary vasodilators, not elsewhere classified
0.154 0.846 0.000
T40.9 Other and unspecified psychodysleptics [hallucinogens]
0.154 0.846 0.000
T40.8 Lysergide [LSD]
0.154 0.846 0.000
T40.7 Cannabis (derivatives)
0.154 0.846 0.000
T40.5 Cocaine
0.154 0.846 0.000
T40.3 Methadone
0.154 0.846 0.000
T40.1 Heroin
0.154 0.846 0.000
T40.0 Opium
0.154 0.846 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.154 0.846 0.000
T45.9 Primarily systemic and haematological agent, unspecified
0.153 0.847 0.000
T45.8 Other primarily systemic and haematological agents
0.153 0.847 0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants
0.153 0.847 0.000
T45.6 Fibrinolysis-affecting drugs
0.153 0.847 0.000
T45.4 Iron and its compounds
0.153 0.847 0.000
T45.3 Enzymes, not elsewhere classified
0.153 0.847 0.000
E12.9 Without complications
0.000 0.847 0.153
E12.8 With unspecified complications
0.000 0.847 0.153
E12.7 With multiple complications
0.000 0.847 0.153
E12.6 With other specified complications
0.000 0.847 0.153
E12.5 With peripheral circulatory complications
0.000 0.847 0.153
E12.4 With neurological complications
0.000 0.847 0.153
E12.3 With ophthalmic complications
0.000 0.847 0.153
E12.2 With renal complications
0.000 0.847 0.153
E12.1 With ketoacidosis
0.000 0.847 0.153
E12.0 With coma
0.000 0.847 0.153
J45.8 Mixed asthma
0.000 0.849 0.150
J45.1 Nonallergic asthma
0.000 0.849 0.150
I07.9 Tricuspid valve disease, unspecified
0.000 0.850 0.150
I07.8 Other tricuspid valve diseases
0.000 0.850 0.150
I07.2 Tricuspid stenosis with insufficiency
0.000 0.850 0.150
I07.0 Tricuspid stenosis
0.000 0.850 0.150
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.854 0.146
I05.8 Other mitral valve diseases
0.000 0.854 0.146
J92 Pleural plaque
0.000 0.856 0.144
T48.6 Antiasthmatics, not elsewhere classified
0.144 0.856 0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system
0.143 0.856 0.000
T46.8 Antivaricose drugs, including sclerosing agents
0.143 0.856 0.000
T46.7 Peripheral vasodilators
0.143 0.856 0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified
0.143 0.856 0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action
0.143 0.856 0.000
I05.0 Mitral stenosis
0.000 0.857 0.143
I95 Hypotension
0.000 0.858 0.142
T46.4 Angiotensin-converting-enzyme inhibitors
0.141 0.859 0.000
E10.6 With other specified complications
0.000 0.860 0.140
T50.9 Other and unspecified drugs, medicaments and biological substances
0.140 0.860 0.000
I05.2 Mitral stenosis with insufficiency
0.000 0.860 0.140
T49.9 Topical agent, unspecified
0.140 0.860 0.000
T49.8 Other topical agents
0.140 0.860 0.000
T49.7 Dental drugs, topically applied
0.140 0.860 0.000
T49.6 Otorhinolaryngological drugs and preparations
0.140 0.860 0.000
T49.5 Ophthalmological drugs and preparations
0.140 0.860 0.000
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations
0.140 0.860 0.000
T49.3 Emollients, demulcents and protectants
0.140 0.860 0.000
T49.2 Local astringents and local detergents
0.140 0.860 0.000
T49.1 Antipruritics
0.140 0.860 0.000
I06.0 Rheumatic aortic stenosis
0.000 0.862 0.138
T45.5 Anticoagulants
0.137 0.863 0.000
E10.0 With coma
0.000 0.863 0.137
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.000 0.865 0.135
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.865 0.135
I98.0 Cardiovascular syphilis
0.000 0.865 0.135
T50.4 Drugs affecting uric acid metabolism
0.135 0.865 0.000
T48.7 Other and unspecified agents primarily acting on the respiratory system
0.134 0.866 0.000
T48.5 Anti-common-cold drugs
0.134 0.866 0.000
T48.4 Expectorants
0.134 0.866 0.000
T48.3 Antitussives
0.134 0.866 0.000
T48.2 Other and unspecified agents primarily acting on muscles
0.134 0.866 0.000
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]
0.134 0.866 0.000
T48.0 Oxytocic drugs
0.134 0.866 0.000
T38.1 Thyroid hormones and substitutes
0.134 0.866 0.000
Chapter X Diseases of the respiratory system
0.000 0.866 0.134
I98.2 Oesophageal varices in diseases classified elsewhere
0.000 0.867 0.133
T50.7 Analeptics and opioid receptor antagonists
0.132 0.867 0.000
T50.6 Antidotes and chelating agents, not elsewhere classified
0.132 0.867 0.000
T50.5 Appetite depressants
0.132 0.867 0.000
T50.3 Electrolytic, caloric and water-balance agents
0.132 0.867 0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
0.132 0.867 0.000
T50.1 Loop [high-ceiling] diuretics
0.132 0.867 0.000
T50.0 Mineralocorticoids and their antagonists
0.132 0.867 0.000
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.132 0.868 0.000
T47.1 Other antacids and anti-gastric-secretion drugs
0.132 0.868 0.000
T37.8 Other specified systemic anti-infectives and antiparasitics
0.132 0.868 0.000
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.000 0.869 0.131
T38.9 Other and unspecified hormone antagonists
0.131 0.869 0.000
T38.8 Other and unspecified hormones and their synthetic substitutes
0.131 0.869 0.000
T38.7 Androgens and anabolic congeners
0.131 0.869 0.000
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified
0.131 0.869 0.000
T38.5 Other oestrogens and progestogens
0.131 0.869 0.000
T38.4 Oral contraceptives
0.131 0.869 0.000
T38.2 Antithyroid drugs
0.131 0.869 0.000
T38.0 Glucocorticoids and synthetic analogues
0.131 0.869 0.000
T50.8 Diagnostic agents
0.129 0.870 0.000
E10.3 With ophthalmic complications
0.000 0.870 0.129
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified
0.129 0.871 0.000
T47.8 Other agents primarily affecting the gastro-intestinal system
0.129 0.871 0.000
T47.7 Emetics
0.129 0.871 0.000
T47.6 Antidiarrhoeal drugs
0.129 0.871 0.000
T47.5 Digestants
0.129 0.871 0.000
T47.4 Other laxatives
0.129 0.871 0.000
T47.3 Saline and osmotic laxatives
0.129 0.871 0.000
T47.2 Stimulant laxatives
0.129 0.871 0.000
T47.0 Histamine H(2)-receptor antagonists
0.129 0.871 0.000
T37.9 Systemic anti-infective and antiparasitic, unspecified
0.129 0.871 0.000
T37.5 Antiviral drugs
0.129 0.871 0.000
T37.4 Anthelminthics
0.129 0.871 0.000
T37.3 Other antiprotozoal drugs
0.129 0.871 0.000
T37.2 Antimalarials and drugs acting on other blood protozoa
0.129 0.871 0.000
T37.1 Antimycobacterial drugs
0.129 0.871 0.000
T37.0 Sulphonamides
0.129 0.871 0.000
E10.4 With neurological complications
0.000 0.871 0.129
J90-J94 Other diseases of pleura
0.000 0.872 0.128
J60-J70 Lung diseases due to external agents
0.000 0.872 0.128
T41.5 Therapeutic gases
0.127 0.873 0.000
T41.4 Anaesthetic, unspecified
0.127 0.873 0.000
T41.3 Local anaesthetics
0.127 0.873 0.000
T41.2 Other and unspecified general anaesthetics
0.127 0.873 0.000
T41.1 Intravenous anaesthetics
0.127 0.873 0.000
T41.0 Inhaled anaesthetics
0.127 0.873 0.000
T46.1 Calcium-channel blockers
0.125 0.874 0.000
I07.1 Tricuspid insufficiency
0.000 0.874 0.125
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified
0.125 0.875 0.000
J61 Pneumoconiosis due to asbestos and other mineral fibres
0.000 0.875 0.125
E10.5 With peripheral circulatory complications
0.000 0.879 0.121
I95.1 Orthostatic hypotension
0.000 0.879 0.121
E10.2 With renal complications
0.000 0.879 0.121
T44.9 Other and unspecified drugs primarily affecting the nervous system
0.121 0.879 0.000
E10.7 With multiple complications
0.000 0.879 0.121
I95.8 Other hypotension
0.000 0.879 0.121
I99 Other and unspecified disorders of circulatory system
0.000 0.881 0.119
E10.8 With unspecified complications
0.000 0.884 0.116
I13 Hypertensive heart and renal disease
0.000 0.884 0.116
T36.9 Systemic antibiotic, unspecified
0.115 0.885 0.000
T36.8 Other systemic antibiotics
0.115 0.885 0.000
T36.7 Antifungal antibiotics, systemically used
0.115 0.885 0.000
T36.6 Rifamycins
0.115 0.885 0.000
T36.5 Aminoglycosides
0.115 0.885 0.000
T36.4 Tetracyclines
0.115 0.885 0.000
T36.3 Macrolides
0.115 0.885 0.000
T36.2 Chloramphenicol group
0.115 0.885 0.000
T36.1 Cefalosporins and other Beta-lactam antibiotics
0.115 0.885 0.000
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified
0.115 0.885 0.000
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified
0.115 0.885 0.000
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified
0.115 0.885 0.000
T44.2 Ganglionic blocking drugs, not elsewhere classified
0.115 0.885 0.000
T44.1 Other parasympathomimetics [cholinergics]
0.115 0.885 0.000
T44.0 Anticholinesterase agents
0.115 0.885 0.000
I62.0 Subdural haemorrhage (acute) (nontraumatic)
0.001 0.887 0.112
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified
0.112 0.888 0.000
I15 Secondary hypertension
0.000 0.890 0.110
J92.9 Pleural plaque without asbestos
0.000 0.891 0.109
I97.9 Postprocedural disorder of circulatory system, unspecified
0.000 0.895 0.105
I97.0 Postcardiotomy syndrome
0.000 0.895 0.105
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.000 0.895 0.105
I97.2 Postmastectomy lymphoedema syndrome
0.000 0.896 0.104
J60 Coalworker's pneumoconiosis
0.000 0.899 0.101
T36.0 Penicillins
0.097 0.903 0.000
J64 Unspecified pneumoconiosis
0.000 0.904 0.096
J69 Pneumonitis due to solids and liquids
0.000 0.905 0.095
J95-J99 Other diseases of the respiratory system
0.000 0.907 0.093
J68 Respiratory conditions due to inhalation of chemicals, gases, fumes and vapours
0.000 0.908 0.092
J66 Airway disease due to specific organic dust
0.000 0.908 0.092
J63 Pneumoconiosis due to other inorganic dusts
0.000 0.908 0.092
J62 Pneumoconiosis due to dust containing silica
0.000 0.908 0.092
J65 Pneumoconiosis associated with tuberculosis
0.000 0.908 0.092
J86 Pyothorax
0.000 0.910 0.090
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.910 0.089
J70 Respiratory conditions due to other external agents
0.000 0.913 0.087
I95.0 Idiopathic hypotension
0.000 0.915 0.085
I12 Hypertensive renal disease
0.000 0.915 0.085
I15.9 Seconday hypertension, unspecified
0.000 0.915 0.085
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.917 0.083
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.917 0.083
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.917 0.083
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.917 0.083
I11 Hypertensive heart disease
0.000 0.917 0.083
I97.1 Other functional disturbances following cardiac surgery
0.000 0.917 0.083
I05.9 Mitral valve disease, unspecified
0.000 0.918 0.082
I15.1 Hypertension secondary to other renal disorders
0.000 0.919 0.081
J86.9 Pyothorax without fistula
0.000 0.919 0.081
I15.8 Other secondary hypertension
0.000 0.921 0.079
I15.2 Hypertension secondary to endocrine disorders
0.000 0.921 0.079
J93 Pneumothorax
0.000 0.921 0.079
J69.8 Pneumonitis due to other solids and liquids
0.000 0.923 0.077
J98 Other respiratory disorders
0.000 0.924 0.076
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified
0.070 0.930 0.000
J98.1 Pulmonary collapse
0.000 0.930 0.070
J69.1 Pneumonitis due to oils and essences
0.000 0.931 0.069
J96 Respiratory failure, not elsewhere classified
0.000 0.933 0.067
J93.1 Other spontaneous pneumothorax
0.000 0.934 0.066
J62.8 Pneumoconiosis due to other dust containing silica
0.000 0.934 0.066
J62.0 Pneumoconiosis due to talc dust
0.000 0.934 0.066
J63.8 Pneumoconiosis due to other specified inorganic dusts
0.000 0.934 0.066
J63.5 Stannosis
0.000 0.934 0.066
J63.4 Siderosis
0.000 0.934 0.066
J63.3 Graphite fibrosis (of lung)
0.000 0.934 0.066
J63.2 Berylliosis
0.000 0.934 0.066
J63.1 Bauxite fibrosis (of lung)
0.000 0.934 0.066
J63.0 Aluminosis (of lung)
0.000 0.934 0.066
J66.8 Airway disease due to other specific organic dusts
0.000 0.934 0.066
J66.2 Cannabinosis
0.000 0.934 0.066
J66.1 Flax-dresser's disease
0.000 0.934 0.066
J66.0 Byssinosis
0.000 0.934 0.066
J68.9 Unspecified respiratory condition due to chemicals, gases, fumes and vapours
0.000 0.934 0.066
J68.8 Other respiratory conditions due to chemicals, gases, fumes and vapours
0.000 0.934 0.066
J68.4 Chronic respiratory conditions due to chemicals, gases, fumes and vapours
0.000 0.934 0.066
J68.3 Other acute and subacute respiratory conditions due to chemicals, gases, fumes and vapours
0.000 0.934 0.066
J68.2 Upper respiratory inflammation due to chemicals, gases, fumes and vapours, not elsewhere classified
0.000 0.934 0.066
J68.1 Acute pulmonary oedema due to chemicals, gases, fumes and vapours
0.000 0.934 0.066
J68.0 Bronchitis and pneumonitis due to chemicals, gases, fumes and vapours
0.000 0.934 0.066
J98.9 Respiratory disorder, unspecified
0.000 0.934 0.066
J91 Pleural effusion in conditions classified elsewhere
0.000 0.935 0.065
J85 Abscess of lung and mediastinum
0.000 0.937 0.063

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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