TreeWAS – Variant ID: rs993226

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability
M19.9 Arthrosis, unspecified	0.240	0.760
M19.99 Arthrosis, unspecified (Site unspecified)	0.234	0.766
M19.90 Arthrosis, unspecified (Multiple sites)	0.234	0.766
M19 Other arthrosis	0.219	0.781
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.215	0.785
M19.98 Arthrosis, unspecified (Other)	0.209	0.791
M19.94 Arthrosis, unspecified (Hand)	0.206	0.794
M45-M49 Spondylopathies	0.206	0.794
M15-M19 Arthrosis	0.204	0.796
M19.91 Arthrosis, unspecified (Shoulder region)	0.197	0.803
M20-M25 Other joint disorders	0.195	0.805
M50-M54 Other dorsopathies	0.194	0.806
M05-M14 Inflammatory polyarthropathies	0.187	0.813
M24 Other specific joint derangements	0.186	0.814
M54 Dorsalgia	0.186	0.814
M65-M68 Disorders of synovium and tendon	0.185	0.815
M25 Other joint disorders, not elsewhere classified	0.185	0.815
M45 Ankylosing spondylitis	0.181	0.819
M47 Spondylosis	0.178	0.822
M91-M94 Chondropathies	0.175	0.825
M54.9 Dorsalgia, unspecified	0.174	0.826
M19.92 Arthrosis, unspecified (Upper arm)	0.174	0.826
M46 Other inflammatory spondylopathies	0.172	0.828
M05 Seropositive rheumatoid arthritis	0.172	0.828
M54.3 Sciatica	0.171	0.829
M60-M63 Disorders of muscles	0.167	0.833
M25.5 Pain in joint	0.166	0.834
M21 Other acquired deformities of limbs	0.165	0.835
M19.95 Arthrosis, unspecified (Pelvic region and thigh)	0.165	0.835
M47.8 Other spondylosis	0.164	0.836
M24.1 Other articular cartilage disorders	0.163	0.837
M32 Systemic lupus erythematosus	0.163	0.837
M19.0 Primary arthrosis of other joints	0.163	0.837
M05.9 Seropositive rheumatoid arthritis, unspecified	0.161	0.839
M00-M03 Infectious arthropathies	0.160	0.840
M33 Dermatopolymyositis	0.159	0.841
M19.97 Arthrosis, unspecified (Ankle and foot)	0.158	0.842
M45.X9 Ankylosing spondylitis (Site unspecified)	0.157	0.843
M25.3 Other instability of joint	0.157	0.843
M19.8 Other specified arthrosis	0.157	0.843
M19.2 Other secondary arthrosis	0.157	0.843
M24.2 Disorder of ligament	0.157	0.843
M70-M79 Other soft tissue disorders	0.156	0.844
M86-M90 Other osteopathies	0.155	0.845
M25.51 Pain in joint (Shoulder region)	0.153	0.847
M25.4 Effusion of joint	0.153	0.847
M54.36 Sciatica (Lumbar region)	0.153	0.847
M19.1 Posttraumatic arthrosis of other joints	0.151	0.849
M47.89 Other spondylosis (Site unspecified)	0.151	0.849
M24.0 Loose body in joint	0.151	0.849
M54.94 Dorsalgia, unspecified (Thoracic region)	0.151	0.849
M19.96 Arthrosis, unspecified-Lower leg	0.150	0.850
M66 Spontaneous rupture of synovium and tendon	0.150	0.850
M49 Spondylopathies in diseases classified elsewhere	0.148	0.852
M10 Gout	0.147	0.853
M24.6 Ankylosis of joint	0.147	0.853
M54.96 Dorsalgia, unspecified (Lumbar region)	0.147	0.853
M15 Polyarthrosis	0.146	0.853
M54.6 Pain in thoracic spine	0.146	0.854
M65 Synovitis and tenosynovitis	0.145	0.855
M53 Other dorsopathies, not elsewhere classified	0.145	0.855
M93 Other osteochondropathies	0.145	0.855
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.145	0.855
M13 Other arthritis	0.145	0.855
M25.6 Stiffness of joint, not elsewhere classified	0.144	0.855
M48 Other spondylopathies	0.143	0.857
M24.8 Other specific joint derangements, not elsewhere classified	0.143	0.857
M67 Other disorders of synovium and tendon	0.143	0.857
M45.X0 Ankylosing spondylitis (Multiple sites in spine)	0.141	0.859
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.140	0.860
M30 Polyarteritis nodosa and related conditions	0.140	0.860
M54.4 Lumbago with sciatica	0.140	0.860
M47.80 Other spondylosis (Multiple sites in spine)	0.140	0.860
M32.1 Systemic lupus erythematosus with organ or system involvement	0.140	0.860
M54.99 Dorsalgia, unspecified (Site unspecified)	0.140	0.860
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.139	0.861
M46.9 Inflammatory spondylopathy, unspecified	0.139	0.861
M25.53 Pain in joint (Forearm)	0.139	0.861
M50 Cervical disk disorders	0.138	0.862
M54.39 Sciatica (Site unspecified)	0.138	0.862
M46.4 Discitis, unspecified	0.137	0.863
M24.27 Disorder of ligament (Ankle and foot)	0.136	0.864
M24.15 Other articular cartilage disorders (Pelvic region and thigh)	0.135	0.865
M14 Arthropathies in other diseases classified elsewhere	0.134	0.865
M12 Other specific arthropathies	0.134	0.865
M09 Juvenile arthritis in diseases classified elsewhere	0.134	0.865
M08 Juvenile arthritis	0.134	0.865
M47.82 Other spondylosis (Cervical region)	0.134	0.866
M25.57 Pain in joint (Ankle and foot)	0.134	0.866
M24.9 Joint derangement, unspecified	0.134	0.866
M24.7 Protrusio acetabuli	0.134	0.866
M24.5 Contracture of joint	0.134	0.866
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.134	0.866
M40-M43 Deforming dorsopathies	0.134	0.866
M54.8 Other dorsalgia	0.134	0.866
M54.0 Panniculitis affecting regions of neck and back	0.134	0.866
M80-M85 Disorders of bone density and structure	0.133	0.867
M25.9 Joint disorder, unspecified	0.133	0.867
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.133	0.867
M25.2 Flail joint	0.133	0.867
M25.1 Fistula of joint	0.133	0.867
M54.5 Low back pain	0.133	0.867
M47.2 Other spondylosis with radiculopathy	0.133	0.867
M62 Other disorders of muscle	0.132	0.868
M25.58 Pain in joint (Other)	0.132	0.868
M21.3 Wrist or foot drop (acquired)	0.132	0.868
M25.31 Other instability of joint (Shoulder region)	0.131	0.868
# Top node	0.131	0.869
M24.02 Loose body in joint (Upper arm)	0.131	0.869
M19.07 Primary arthrosis of other joints (Ankle and foot)	0.130	0.870
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)	0.130	0.870
M45.X7 Ankylosing spondylitis (Lumbosacral region)	0.130	0.870
M45.X6 Ankylosing spondylitis (Lumbar region)	0.130	0.870
M45.X5 Ankylosing spondylitis (Thoracolumbar region)	0.130	0.870
M45.X4 Ankylosing spondylitis (Thoracic region)	0.130	0.870
M45.X3 Ankylosing spondylitis (Cervicothoracic region)	0.130	0.870
M45.X2 Ankylosing spondylitis (Cervical region)	0.130	0.870
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)	0.130	0.870
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.130	0.870
M25.0 Haemarthrosis	0.129	0.871
M21.1 Varus deformity, not elsewhere classified	0.129	0.871
M25.59 Pain in joint (Site unspecified)	0.129	0.871
M11 Other crystal arthropathies	0.129	0.871
M72 Fibroblastic disorders	0.129	0.871
M19.93 Arthrosis, unspecified (Forearm)	0.129	0.871
M24.16 Other articular cartilage disorders (Lower leg)	0.128	0.871
M34 Systemic sclerosis	0.128	0.871
M47.0 Anterior spinal and vertebral artery compression syndromes	0.127	0.872
M54.37 Sciatica (Lumbosacral region)	0.127	0.873
M94 Other disorders of cartilage	0.126	0.873
M65.9 Synovitis and tenosynovitis, unspecified	0.126	0.874
M13.0 Polyarthritis, unspecified	0.126	0.874
M24.11 Other articular cartilage disorders (Shoulder region)	0.126	0.874
M92 Other juvenile osteochondrosis	0.125	0.874
M91 Juvenile osteochondrosis of hip and pelvis	0.125	0.874
M33.2 Polymyositis	0.125	0.874
M25.64 Stiffness of joint, not elsewhere classified (Hand)	0.125	0.875
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.125	0.875
M54.98 Dorsalgia, unspecified (Sacral and sacrococcygeal region)	0.125	0.875
M54.97 Dorsalgia, unspecified (Lumbosacral region)	0.125	0.875
M54.95 Dorsalgia, unspecified (Thoracolumbar region)	0.125	0.875
M54.93 Dorsalgia, unspecified (Cervicothoracic region)	0.125	0.875
M54.92 Dorsalgia, unspecified (Cervical region)	0.125	0.875
M54.91 Dorsalgia, unspecified (Occipito-atlanto-axial region)	0.125	0.875
M54.90 Dorsalgia, unspecified (Multiple sites in spine)	0.125	0.875
M79 Other soft tissue disorders, not elsewhere classified	0.125	0.875
M19.03 Primary arthrosis of other joints (Forearm)	0.124	0.875
M93.9 Osteochondropathy, unspecified	0.124	0.876
M35 Other systemic involvement of connective tissue	0.124	0.876
M25.45 Effusion of joint (Pelvic region and thigh)	0.124	0.876
M33.1 Other dermatomyositis	0.124	0.876
M21.0 Valgus deformity, not elsewhere classified	0.124	0.876
M46.8 Other specified inflammatory spondylopathies	0.124	0.876
M46.5 Other infective spondylopathies	0.124	0.876
M46.3 Infection of intervertebral disk (pyogenic)	0.124	0.876
M46.2 Osteomyelitis of vertebra	0.124	0.876
M46.1 Sacro-iliitis, not elsewhere classified	0.124	0.876
M46.0 Spinal enthesopathy	0.124	0.876
M05.8 Other seropositive rheumatoid arthritis	0.123	0.876
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.123	0.876
M05.2 Rheumatoid vasculitis	0.123	0.876
M05.1 Rheumatoid lung disease	0.123	0.876
M05.0 Felty's syndrome	0.123	0.876
M25.37 Other instability of joint (Ankle and foot)	0.123	0.877
M89 Other disorders of bone	0.123	0.877
M25.47 Effusion of joint (Ankle and foot)	0.123	0.877
M54.38 Sciatica (Sacral and sacrococcygeal region)	0.123	0.877
M54.35 Sciatica (Thoracolumbar region)	0.123	0.877
M54.34 Sciatica-Thoracic	0.123	0.877
M54.33 Sciatica-Cervicothoracic	0.123	0.877
M54.32 Sciatica-Cervical	0.123	0.877
M54.31 Sciatica-Occipit-atl-axl	0.123	0.877
M54.30 Sciatica (Multiple sites in spine)	0.123	0.877
M47.1 Other spondylosis with myelopathy	0.121	0.878
Chapter I Certain infectious and parasitic diseases	0.121	0.879
M24.4 Recurrent dislocation and subluxation of joint	0.121	0.879
M00 Pyogenic arthritis	0.121	0.879
M54.57 Low back pain (Lumbosacral region)	0.120	0.880
F31 Bipolar affective disorder	0.120	0.880
M63 Disorders of muscle in diseases classified elsewhere	0.120	0.880
M61 Calcification and ossification of muscle	0.120	0.880
M60 Myositis	0.120	0.880
M25.7 Osteophyte	0.120	0.880
D50-D53 Nutritional anaemias	0.119	0.881
Chapter V Mental and behavioural disorders	0.119	0.881
M66.0 Rupture of popliteal cyst	0.119	0.881
M24.67 Ankylosis of joint (Ankle and foot)	0.119	0.881
M10.9 Gout, unspecified	0.118	0.882
M21.9 Acquired deformity of limb, unspecified	0.118	0.882
M21.8 Other specified acquired deformities of limbs	0.118	0.882
M21.7 Unequal limb length (acquired)	0.118	0.882
M21.6 Other acquired deformities of ankle and foot	0.118	0.882
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.118	0.882
M21.4 Flat foot [pes planus] (acquired)	0.118	0.882
M21.2 Flexion deformity	0.118	0.882
M24.13 Other articular cartilage disorders (Forearm)	0.118	0.882
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.118	0.882
M47.88 Other spondylosis (Sacral and sacrococcygeal region)	0.117	0.882
M47.85 Other spondylosis (Thoracolumbar region)	0.117	0.882
M47.84 Other spondylosis (Thoracic region)	0.117	0.882
M47.83 Other spondylosis (Cervicothoracic region)	0.117	0.882
M47.81 Other spondylosis (Occipito-atlanto-axial region)	0.117	0.882
M76 Enthesopathies of lower limb, excluding foot	0.117	0.883
M24.19 Other articular cartilage disorders (Site unspecified)	0.117	0.883
M24.18 Other articular cartilage disorders (Other)	0.117	0.883
M24.17 Other articular cartilage disorders (Ankle and foot)	0.117	0.883
M24.14 Other articular cartilage disorders (Hand)	0.117	0.883
M24.12 Other articular cartilage disorders (Upper arm)	0.117	0.883
M24.10 Other articular cartilage disorders (Multiple sites)	0.117	0.883
F30-F39 Mood [affective] disorders	0.117	0.883
M32.9 Systemic lupus erythematosus, unspecified	0.117	0.883
M32.8 Other forms of systemic lupus erythematosus	0.117	0.883
M32.0 Drug-induced systemic lupus erythematosus	0.117	0.883
M25.52 Pain in joint (Upper arm)	0.117	0.883
M19.08 Primary arthrosis of other joints (Other)	0.117	0.883
M19.06 Primary arthrosis of other joints-Lower leg	0.117	0.883
M19.05 Primary arthrosis of other joints (Pelvic region and thigh)	0.117	0.883
M19.02 Primary arthrosis of other joints (Upper arm)	0.117	0.883
M19.00 Primary arthrosis of other joints (Multiple sites)	0.117	0.883
M54.64 Pain in thoracic spine (Thoracic region)	0.117	0.883
M25.8 Other specified joint disorders	0.117	0.883
M07 Psoriatic and enteropathic arthropathies	0.117	0.883
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)	0.116	0.884
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)	0.116	0.884
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)	0.116	0.884
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.116	0.884
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)	0.116	0.884
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)	0.116	0.884
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)	0.116	0.884
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)	0.116	0.884
M19.09 Primary arthrosis of other joints (Site unspecified)	0.115	0.885
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.115	0.885
M02 Reactive arthropathies	0.115	0.885
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.115	0.885
M66.2 Spontaneous rupture of extensor tendons	0.115	0.885
M33.9 Dermatopolymyositis, unspecified	0.114	0.886
M33.0 Juvenile dermatomyositis	0.114	0.886
D80-D89 Certain disorders involving the immune mechanism	0.113	0.886
M25.50 Pain in joint (Multiple sites)	0.113	0.887
M25.39 Other instability of joint (Site unspecified)	0.113	0.887
M25.38 Other instability of joint (Other)	0.113	0.887
M25.36 Other instability of joint (Lower leg)	0.113	0.887
M25.35 Other instability of joint (Pelvic region and thigh)	0.113	0.887
M25.34 Other instability of joint (Hand)	0.113	0.887
M25.33 Other instability of joint (Forearm)	0.113	0.887
M25.32 Other instability of joint (Upper arm)	0.113	0.887
M25.30 Other instability of joint (Multiple sites)	0.113	0.887
M19.29 Other secondary arthrosis (Site unspecified)	0.113	0.887
M19.28 Other secondary arthrosis (Other)	0.113	0.887
M19.27 Other secondary arthrosis (Ankle and foot)	0.113	0.887
M19.26 Other secondary arthrosis of other joints-Lower leg	0.113	0.887
M19.25 Other secondary arthrosis (Pelvic region and thigh)	0.113	0.887
M19.24 Other secondary arthrosis (Hand)	0.113	0.887
M19.23 Other secondary arthrosis (Forearm)	0.113	0.887
M19.22 Other secondary arthrosis (Upper arm)	0.113	0.887
M19.21 Other secondary arthrosis (Shoulder region)	0.113	0.887
M19.20 Other secondary arthrosis (Multiple sites)	0.113	0.887
M19.89 Other specified arthrosis (Site unspecified)	0.113	0.887
M19.88 Other specified arthrosis (Other)	0.113	0.887
M19.87 Other specified arthrosis (Ankle and foot)	0.113	0.887
M19.86 Other specified arthrosis (Lower leg)	0.113	0.887
M19.85 Other specified arthrosis (Pelvic region and thigh)	0.113	0.887
M19.84 Other specified arthrosis (Hand)	0.113	0.887
M19.83 Other specified arthrosis (Forearm)	0.113	0.887
M19.82 Other specified arthrosis (Upper arm)	0.113	0.887
M19.81 Other specified arthrosis (Shoulder region)	0.113	0.887
M19.80 Other specified arthrosis (Multiple sites)	0.113	0.887
M18 Arthrosis of first carpometacarpal joint	0.113	0.887
M13.00 Polyarthritis, unspecified (Multiple sites)	0.113	0.887
S01 Open wound of head	0.113	0.887
M24.29 Disorder of ligament (Site unspecified)	0.113	0.887
M24.28 Disorder of ligament (Other)	0.113	0.887
M24.26 Disorder of ligament (Lower leg)	0.113	0.887
M24.25 Disorder of ligament (Pelvic region and thigh)	0.113	0.887
M24.24 Disorder of ligament (Hand)	0.113	0.887
M24.23 Disorder of ligament (Forearm)	0.113	0.887
M24.22 Disorder of ligament (Upper arm)	0.113	0.887
M24.21 Disorder of ligament (Shoulder region)	0.113	0.887
M24.20 Disorder of ligament (Multiple sites)	0.113	0.887
M06 Other rheumatoid arthritis	0.112	0.888
M46.46 Discitis, unspecified (Lumbar region)	0.112	0.888
M73 Soft tissue disorders in diseases classified elsewhere	0.112	0.888
M90 Osteopathies in diseases classified elsewhere	0.112	0.888
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)	0.112	0.888
M50.2 Other cervical disk displacement	0.111	0.889
M67.2 Synovial hypertrophy, not elsewhere classified	0.111	0.889
M46.92 Inflammatory spondylopathy, unspecified (Cervical region)	0.111	0.889
Chapter XXII Codes for special purposes	0.111	0.889
S00-S09 Injuries to the head	0.111	0.889
F31.9 Bipolar affective disorder, unspecified	0.111	0.889
M19.04 Primary arthrosis of other joints (Hand)	0.110	0.889
A00-A09 Intestinal infectious diseases	0.111	0.889
M65.97 Synovitis and tenosynovitis, unspecified (Ankle and foot)	0.110	0.890
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.110	0.890
M53.3 Sacrococcygeal disorders, not elsewhere classified	0.110	0.890
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.110	0.890
Chapter IV Endocrine, nutritional and metabolic diseases	0.110	0.890
M25.49 Effusion of joint (Site unspecified)	0.110	0.890
M25.48 Effusion of joint (Other)	0.110	0.890
M25.44 Effusion of joint (Hand)	0.110	0.890
M25.43 Effusion of joint (Forearm)	0.110	0.890
M25.42 Effusion of joint (Upper arm)	0.110	0.890
M25.41 Effusion of joint (Shoulder region)	0.110	0.890
M25.40 Effusion of joint (Multiple sites)	0.110	0.890
M70 Soft tissue disorders related to use, overuse and pressure	0.109	0.890
M54.1 Radiculopathy	0.109	0.891
B95-B98 Bacterial, viral and other infectious agents	0.109	0.891
M19.19 Post-traumatic arthrosis of other joints (Site unspecified)	0.108	0.891
M19.18 Post-traumatic arthrosis of other joints (Other)	0.108	0.891
M19.16 Post-traumatic arthrosis of other joints-Lower leg	0.108	0.891
M19.15 Post-traumatic arthrosis of other joints (Pelvic region and thigh)	0.108	0.891
M19.14 Post-traumatic arthrosis of other joints (Hand)	0.108	0.891
M19.13 Post-traumatic arthrosis of other joints (Forearm)	0.108	0.891
M19.12 Post-traumatic arthrosis of other joints (Upper arm)	0.108	0.891
M19.11 Post-traumatic arthrosis of other joints (Shoulder region)	0.108	0.891
M19.10 Post-traumatic arthrosis of other joints (Multiple sites)	0.108	0.891
M24.09 Loose body in joint (Site unspecified)	0.108	0.891
M24.08 Loose body in joint (Other)	0.108	0.891
M24.06 Loose body in joint-Lower leg	0.108	0.891
M24.05 Loose body in joint (Pelvic region and thigh)	0.108	0.891
M24.04 Loose body in joint (Hand)	0.108	0.891
M24.03 Loose body in joint (Forearm)	0.108	0.891
M24.01 Loose body in joint (Shoulder region)	0.108	0.891
M24.00 Loose body in joint (Multiple sites)	0.108	0.891
Q50-Q56 Congenital malformations of genital organs	0.108	0.891
M87 Osteonecrosis	0.108	0.892
M21.37 Wrist or foot drop (acquired) (Ankle and foot)	0.108	0.892
M47.87 Other spondylosis (Lumbosacral region)	0.108	0.892
M46.99 Inflammatory spondylopathy, unspecified (Site unspecified)	0.108	0.892
M65.4 Radial styloid tenosynovitis [de Quervain]	0.108	0.892
M47.9 Spondylosis, unspecified	0.108	0.892
M79.1 Myalgia	0.108	0.892
M66.5 Spontaneous rupture of unspecified tendon	0.107	0.892
M66.4 Spontaneous rupture of other tendons	0.107	0.892
M66.3 Spontaneous rupture of flexor tendons	0.107	0.892
M66.1 Rupture of synovium	0.107	0.892
M54.46 Lumbago with sciatica (Lumbar region)	0.107	0.893
S01.8 Open wound of other parts of head	0.107	0.893
M72.2 Plantar fascial fibromatosis	0.107	0.893
M86 Osteomyelitis	0.107	0.893
M62.8 Other specified disorders of muscle	0.107	0.893
M71 Other bursopathies	0.107	0.893
D51 Vitamin B12 deficiency anaemia	0.107	0.893
M65.8 Other synovitis and tenosynovitis	0.107	0.893
Chapter XI Diseases of the digestive system	0.107	0.893
M67.8 Other specified disorders of synovium and tendon	0.106	0.894
M49.8 Spondylopathy in other diseases classified elsewhere	0.106	0.894
M49.5 Collapsed vertebra in diseases classified elsewhere	0.106	0.894
M49.4 Neuropathic spondylopathy	0.106	0.894
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere	0.106	0.894
M49.2 Enterobacterial spondylitis	0.106	0.894
M49.1 Brucella spondylitis	0.106	0.894
M49.0 Tuberculosis of spine	0.106	0.894
K70-K77 Diseases of liver	0.106	0.894
F31.0 Bipolar affective disorder, current episode hypomanic	0.106	0.894
M10.4 Other secondary gout	0.106	0.894
M10.3 Gout due to impairment of renal function	0.106	0.894
M10.2 Drug-induced gout	0.106	0.894
M10.1 Lead-induced gout	0.106	0.894
M10.0 Idiopathic gout	0.106	0.894
Chapter VII Diseases of the eye and adnexa	0.106	0.894
M24.69 Ankylosis of joint (Site unspecified)	0.105	0.894
M24.68 Ankylosis of joint (Other)	0.105	0.894
M24.66 Ankylosis of joint (Lower leg)	0.105	0.894
M24.65 Ankylosis of joint (Pelvic region and thigh)	0.105	0.894
M24.64 Ankylosis of joint (Hand)	0.105	0.894
M24.63 Ankylosis of joint (Forearm)	0.105	0.894
M24.62 Ankylosis of joint (Upper arm)	0.105	0.894
M24.61 Ankylosis of joint (Shoulder region)	0.105	0.894
M24.60 Ankylosis of joint (Multiple sites)	0.105	0.894
M48.5 Collapsed vertebra, not elsewhere classified	0.105	0.894
M15.9 Polyarthrosis, unspecified	0.105	0.895
M15.0 Primary generalised (osteo)arthrosis	0.105	0.895
M15.8 Other polyarthrosis	0.105	0.895
M15.4 Erosive (osteo)arthrosis	0.105	0.895
M15.3 Secondary multiple arthrosis	0.105	0.895
M15.2 Bouchard's nodes (with arthropathy)	0.105	0.895
M15.1 Heberden's nodes (with arthropathy)	0.105	0.895
M82 Osteoporosis in diseases classified elsewhere	0.105	0.895
A08 Viral and other specified intestinal infections	0.105	0.895
M19.01 Primary arthrosis of other joints (Shoulder region)	0.105	0.895
M25.46 Effusion of joint (Lower leg)	0.105	0.895
M47.22 Other spondylosis with radiculopathy (Cervical region)	0.105	0.895
E20-E35 Disorders of other endocrine glands	0.105	0.895
M54.69 Pain in thoracic spine-Site unspe	0.105	0.895
M54.68 Pain in thoracic spine-Sacral/sacrococ	0.105	0.895
M54.67 Pain in thoracic spine-Lumbosacral	0.105	0.895
M54.66 Pain in thoracic spine-Lumbar	0.105	0.895
M54.65 Pain in thoracic spine (Thoracolumbar region)	0.105	0.895
M54.63 Pain in thoracic spine (Cervicothoracic region)	0.105	0.895
M54.62 Pain in thoracic spine-Cervical	0.105	0.895
M54.61 Pain in thoracic spine-Occipit-atl-axl	0.105	0.895
M54.60 Pain in thoracic spine (Multiple sites in spine)	0.105	0.895
M65.2 Calcific tendinitis	0.104	0.895
M65.1 Other infective (teno)synovitis	0.104	0.895
M65.0 Abscess of tendon sheath	0.104	0.895
M25.54 Pain in joint (Hand)	0.104	0.895
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms	0.104	0.895
M53.9 Dorsopathy, unspecified	0.104	0.895
M53.8 Other specified dorsopathies	0.104	0.895
M53.2 Spinal instabilities	0.104	0.895
M53.1 Cervicobrachial syndrome	0.104	0.895
M53.0 Cervicocranial syndrome	0.104	0.895
M93.8 Other specified osteochondropathies	0.104	0.896
M93.2 Osteochondritis dissecans	0.104	0.896
M93.1 Kienbock's disease of adults	0.104	0.896
M93.0 Slipped upper femoral epiphysis (nontraumatic)	0.104	0.896
M13.8 Other specified arthritis	0.104	0.896
M13.1 Monoarthritis, not elsewhere classified	0.104	0.896
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)	0.104	0.896
M25.68 Stiffness of joint, not elsewhere classified (Other)	0.104	0.896
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.104	0.896
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)	0.104	0.896
M25.63 Stiffness of joint, not elsewhere classified (Forearm)	0.104	0.896
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)	0.104	0.896
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.104	0.896
M25.77 Osteophyte (Ankle and foot)	0.103	0.897
M48.9 Spondylopathy, unspecified	0.103	0.897
M48.8 Other specified spondylopathies	0.103	0.897
M48.4 Fatigue fracture of vertebra	0.103	0.897
M48.3 Traumatic spondylopathy	0.103	0.897
M48.2 Kissing spine	0.103	0.897
M48.1 Ankylosing hyperostosis [Forestier]	0.103	0.897
M79.2 Neuralgia and neuritis, unspecified	0.103	0.897
Chapter XX External causes of morbidity and mortality	0.103	0.897
M24.89 Other specific joint derangements, not elsewhere classified (Site unspecified)	0.103	0.897
M24.88 Other specific joint derangements, not elsewhere classified (Other)	0.103	0.897
M24.87 Other specific joint derangements, not elsewhere classified (Ankle and foot)	0.103	0.897
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)	0.103	0.897
M24.84 Other specific joint derangements, not elsewhere classified (Hand)	0.103	0.897
M24.83 Other specific joint derangements, not elsewhere classified (Forearm)	0.103	0.897
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)	0.103	0.897
M24.81 Other specific joint derangements, not elsewhere classified (Shoulder region)	0.103	0.897
M24.80 Other specific joint derangements, not elsewhere classified (Multiple sites)	0.103	0.897
M67.9 Disorder of synovium and tendon, unspecified	0.102	0.897
M67.4 Ganglion	0.102	0.897
M67.3 Transient synovitis	0.102	0.897
M67.0 Short Achilles tendon (acquired)	0.102	0.897
M19.17 Post-traumatic arthrosis of other joints (Ankle and foot)	0.102	0.898
K50-K52 Noninfective enteritis and colitis	0.102	0.898
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)	0.102	0.898
M88 Paget's disease of bone [osteitis deformans]	0.101	0.898
S01.0 Open wound of scalp	0.102	0.898
M30.8 Other conditions related to polyarteritis nodosa	0.101	0.899
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]	0.101	0.899
M30.2 Juvenile polyarteritis	0.101	0.899
M30.1 Polyarteritis with lung involvement [Churg-Strauss]	0.101	0.899
M30.0 Polyarteritis nodosa	0.101	0.899
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere	0.101	0.899
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.101	0.899
M36.3 Arthropathy in other blood disorders	0.101	0.899
M36.2 Haemophilic arthropathy	0.101	0.899
M36.1 Arthropathy in neoplastic disease	0.101	0.899
M36.0 Dermato(poly)myositis in neoplastic disease	0.101	0.899
M54.49 Lumbago with sciatica (Site unspecified)	0.101	0.899
M54.48 Lumbago with sciatica (Sacral and sacrococcygeal region)	0.101	0.899
M54.47 Lumbago with sciatica (Lumbosacral region)	0.101	0.899
M54.45 Lumbago with sciatica (Thoracolumbar region)	0.101	0.899
M54.44 Lumbago with sciatica-Thoracic	0.101	0.899
M54.43 Lumbago with sciatica-Cervicothoracic	0.101	0.899
M54.42 Lumbago with sciatica-Cervical	0.101	0.899
M54.41 Lumbago with sciatica-Occipit-atl-axl	0.101	0.899
M54.40 Lumbago with sciatica (Multiple sites in spine)	0.101	0.899
A08.4 Viral intestinal infection, unspecified	0.101	0.899
Q38-Q45 Other congenital malformations of the digestive system	0.100	0.899
Chapter VIII Diseases of the ear and mastoid process	0.100	0.900
M35.0 Sicca syndrome [Sjogren]	0.100	0.900
M21.16 Varus deformity, not elsewhere classified (Lower leg)	0.100	0.900
D60-D64 Aplastic and other anaemias	0.100	0.900
S02 Fracture of skull and facial bones	0.100	0.900
M67.1 Other contracture of tendon (sheath)	0.100	0.900
M46.98 Inflammatory spondylopathy, unspecified (Sacral and sacrococcygeal region)	0.100	0.900
M46.97 Inflammatory spondylopathy, unspecified (Lumbosacral region)	0.100	0.900
M46.95 Inflammatory spondylopathy, unspecified (Thoracolumbar region)	0.100	0.900
M46.94 Inflammatory spondylopathy, unspecified (Thoracic region)	0.100	0.900
M46.93 Inflammatory spondylopathy, unspecified (Cervicothoracic region)	0.100	0.900
M46.91 Inflammatory spondylopathy, unspecified (Occipito-atlanto-axial region)	0.100	0.900
M46.90 Inflammatory spondylopathy, unspecified (Multiple sites in spine)	0.100	0.900
D70-D77 Other diseases of blood and blood-forming organs	0.100	0.900
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.099	0.901
M50.9 Cervical disk disorder, unspecified	0.099	0.901
M50.8 Other cervical disk disorders	0.099	0.901
M22 Disorders of patella	0.099	0.901
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.099	0.901
Q76 Congenital malformations of spine and bony thorax	0.099	0.901
D86 Sarcoidosis	0.099	0.901
M46.49 Discitis, unspecified (Site unspecified)	0.098	0.901
M46.48 Discitis, unspecified (Sacral and sacrococcygeal region)	0.098	0.901
M46.47 Discitis, unspecified (Lumbosacral region)	0.098	0.901
M46.45 Discitis, unspecified (Thoracolumbar region)	0.098	0.901
M46.44 Discitis, unspecified (Thoracic region)	0.098	0.901
M46.43 Discitis, unspecified (Cervicothoracic region)	0.098	0.901
M46.42 Discitis, unspecified (Cervical region)	0.098	0.901
M46.41 Discitis, unspecified (Occipito-atlanto-axial region)	0.098	0.901
M46.40 Discitis, unspecified (Multiple sites in spine)	0.098	0.901
Q80-Q89 Other congenital malformations	0.098	0.901
M79.0 Rheumatism, unspecified	0.098	0.902
T15-T19 Effects of foreign body entering through natural orifice	0.098	0.902
M10.99 Gout, unspecified (Site unspecified)	0.098	0.902
M89.0 Algoneurodystrophy	0.098	0.902

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations