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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs1046080
log Bayes Factor = 173.349
Chromosome 6   position 31,595,882  (GRCh37) Explore rs1046080 on Ensembl!
Variant rs1046080 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
# Top node
0.000 0.000 1.000
L40-L45 Papulosquamous disorders
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
I20 Angina pectoris
0.000 0.000 1.000
E10.4 With neurological complications
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
H36 Retinal disorders in diseases classified elsewhere
0.000 0.000 1.000
M05 Seropositive rheumatoid arthritis
0.000 0.000 1.000
I20.9 Angina pectoris, unspecified
0.000 0.000 1.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.000 1.000
H30-H36 Disorders of choroid and retina
0.000 0.000 1.000
D64.9 Anaemia, unspecified
0.000 0.000 1.000
L43 Lichen planus
0.000 0.000 1.000
M45 Ankylosing spondylitis
0.000 0.001 0.999
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.001 0.999
Chapter VII Diseases of the eye and adnexa
0.000 0.001 0.999
E83.1 Disorders of iron metabolism
0.999 0.001 0.000
M07 Psoriatic and enteropathic arthropathies
0.000 0.001 0.999
E14.9 Without complications
0.000 0.001 0.999
E11.3 With ophthalmic complications
0.000 0.001 0.999
L43.9 Lichen planus, unspecified
0.000 0.001 0.999
M07.3 Other psoriatic arthropathies
0.000 0.001 0.999
I22 Subsequent myocardial infarction
0.000 0.001 0.999
Chapter IX Diseases of the circulatory system
0.000 0.002 0.998
E14.3 With ophthalmic complications
0.000 0.002 0.998
M45-M49 Spondylopathies
0.000 0.002 0.998
E78.0 Pure hypercholesterolaemia
0.000 0.003 0.997
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.003 0.997
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.003 0.997
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.004 0.996
E70-E90 Metabolic disorders
0.000 0.004 0.996
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.006 0.994
G35-G37 Demyelinating diseases of the central nervous system
0.990 0.006 0.004
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.006 0.994
E10.5 With peripheral circulatory complications
0.000 0.008 0.992
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.009 0.991
I21 Acute myocardial infarction
0.000 0.011 0.989
D64 Other anaemias
0.000 0.011 0.989
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.011 0.989
G37 Other demyelinating diseases of central nervous system
0.987 0.012 0.001
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.013 0.987
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.013 0.987
I10-I15 Hypertensive diseases
0.000 0.015 0.985
D60-D64 Aplastic and other anaemias
0.000 0.015 0.985
G37.9 Demyelinating disease of central nervous system, unspecified
0.984 0.016 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.016 0.984
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.016 0.984
H43-H45 Disorders of vitreous body and globe
0.000 0.016 0.984
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.018 0.982
M06.0 Seronegative rheumatoid arthritis
0.000 0.018 0.982
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.020 0.980
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.020 0.980
H43 Disorders of vitreous body
0.000 0.021 0.979
E06 Thyroiditis
0.000 0.024 0.976
M35.3 Polymyalgia rheumatica
0.000 0.029 0.971
I21.9 Acute myocardial infarction, unspecified
0.000 0.031 0.969
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.033 0.967
E16 Other disorders of pancreatic internal secretion
0.000 0.033 0.967
I20.0 Unstable angina
0.000 0.038 0.962
E10.2 With renal complications
0.000 0.038 0.962
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.038 0.962
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.038 0.962
M35 Other systemic involvement of connective tissue
0.000 0.038 0.962
H34 Retinal vascular occlusions
0.000 0.040 0.960
I24 Other acute ischaemic heart diseases
0.000 0.040 0.960
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.041 0.959
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.042 0.958
E06.3 Autoimmune thyroiditis
0.000 0.043 0.957
E16.2 Hypoglycaemia, unspecified
0.000 0.044 0.956
M20-M25 Other joint disorders
0.000 0.046 0.954
I12 Hypertensive renal disease
0.000 0.047 0.953
I25.5 Ischaemic cardiomyopathy
0.000 0.048 0.952
E05.9 Thyrotoxicosis, unspecified
0.000 0.049 0.951
E11.5 With peripheral circulatory complications
0.000 0.055 0.945
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.060 0.940
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.062 0.938
M06.3 Rheumatoid nodule
0.000 0.065 0.935
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.068 0.932
L40.0 Psoriasis vulgaris
0.000 0.068 0.932
E78.2 Mixed hyperlipidaemia
0.000 0.068 0.932
I12.9 Hypertensive renal disease without renal failure
0.000 0.072 0.928
E10.0 With coma
0.000 0.079 0.921
H34.8 Other retinal vascular occlusions
0.000 0.081 0.919
E10.8 With unspecified complications
0.000 0.085 0.915
H43.8 Other disorders of vitreous body
0.000 0.085 0.915
E10.6 With other specified complications
0.000 0.088 0.912
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.094 0.906
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.110 0.890
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.113 0.886
I10 Essential (primary) hypertension
0.000 0.115 0.885
E11.1 With ketoacidosis
0.000 0.121 0.879
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.121 0.879
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.878 0.122 0.000
H43.1 Vitreous haemorrhage
0.000 0.125 0.875
H43.3 Other vitreous opacities
0.000 0.126 0.874
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.127 0.873
Chapter VI Diseases of the nervous system
0.019 0.133 0.849
E78.8 Other disorders of lipoprotein metabolism
0.000 0.133 0.867
L43.8 Other lichen planus
0.000 0.135 0.865
L40.8 Other psoriasis
0.000 0.142 0.858
H30 Chorioretinal inflammation
0.000 0.144 0.856
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.000 0.146 0.854
I15 Secondary hypertension
0.000 0.151 0.849
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.151 0.849
M34 Systemic sclerosis
0.000 0.156 0.844
K90 Intestinal malabsorption
0.000 0.157 0.843
G50-G59 Nerve, nerve root and plexus disorders
0.002 0.162 0.836
G56.0 Carpal tunnel syndrome
0.000 0.168 0.832
G56 Mononeuropathies of upper limb
0.000 0.169 0.831
G59 Mononeuropathy in diseases classified elsewhere
0.001 0.171 0.829
G59.0 Diabetic mononeuropathy
0.000 0.176 0.824
E11.2 With renal complications
0.000 0.181 0.819
M06.34 Rheumatoid nodule (Hand)
0.000 0.181 0.819
H43.9 Disorder of vitreous body, unspecified
0.000 0.183 0.817
K70-K77 Diseases of liver
0.000 0.185 0.815
H20 Iridocyclitis
0.000 0.186 0.813
M35.7 Hypermobility syndrome
0.000 0.187 0.813
G37.8 Other specified demyelinating diseases of central nervous system
0.811 0.189 0.001
G70-G73 Diseases of myoneural junction and muscle
0.004 0.189 0.807
Chapter XI Diseases of the digestive system
0.000 0.190 0.810
K90-K93 Other diseases of the digestive system
0.000 0.190 0.810
K75 Other inflammatory liver diseases
0.000 0.191 0.809
H43.2 Crystalline deposits in vitreous body
0.000 0.191 0.809
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.193 0.807
E78.4 Other hyperlipidaemia
0.000 0.194 0.806
K75.4 Autoimmune hepatitis
0.000 0.194 0.806
I05-I09 Chronic rheumatic heart diseases
0.000 0.195 0.805
E74 Other disorders of carbohydrate metabolism
0.000 0.198 0.802
E14.6 With other specified complications
0.000 0.198 0.802
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.199 0.801
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.199 0.801
M14 Arthropathies in other diseases classified elsewhere
0.000 0.200 0.800
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.206 0.794
K74 Fibrosis and cirrhosis of liver
0.000 0.207 0.793
M34.1 CR(E)ST syndrome
0.000 0.210 0.790
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.211 0.789
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.213 0.787
G90-G99 Other disorders of the nervous system
0.003 0.215 0.782
E14.5 With peripheral circulatory complications
0.000 0.215 0.785
I25.3 Aneurysm of heart
0.000 0.219 0.781
K74.3 Primary biliary cirrhosis
0.000 0.221 0.779
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.222 0.778
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.227 0.773
M35.1 Other overlap syndromes
0.000 0.239 0.761
G91 Hydrocephalus
0.001 0.239 0.760
H35 Other retinal disorders
0.000 0.240 0.760
E11.0 With coma
0.000 0.242 0.758
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.242 0.758
H30.9 Chorioretinal inflammation, unspecified
0.000 0.246 0.754
G91.9 Hydrocephalus, unspecified
0.000 0.247 0.753
E14.1 With ketoacidosis
0.000 0.250 0.750
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.252 0.748
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.253 0.747
K72 Hepatic failure, not elsewhere classified
0.000 0.254 0.746
E89.3 Postprocedural hypopituitarism
0.000 0.255 0.745
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.003 0.258 0.740
H20.9 Iridocyclitis, unspecified
0.000 0.261 0.739
E40-E46 Malnutrition
0.000 0.263 0.737
M49 Spondylopathies in diseases classified elsewhere
0.000 0.263 0.737
I15.1 Hypertension secondary to other renal disorders
0.000 0.264 0.736
E89.0 Postprocedural hypothyroidism
0.000 0.265 0.735
E11.6 With other specified complications
0.000 0.266 0.734
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.267 0.733
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.269 0.731
M12 Other specific arthropathies
0.000 0.270 0.730
K74.5 Biliary cirrhosis, unspecified
0.000 0.271 0.729
E11.4 With neurological complications
0.000 0.271 0.729
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.272 0.728
H34.2 Other retinal artery occlusions
0.000 0.272 0.728
I00-I02 Acute rheumatic fever
0.000 0.274 0.726
H35.8 Other specified retinal disorders
0.000 0.274 0.726
E06.5 Other chronic thyroiditis
0.000 0.275 0.725
D62 Acute posthaemorrhagic anaemia
0.000 0.276 0.724
M06.4 Inflammatory polyarthropathy
0.000 0.276 0.724
H34.9 Retinal vascular occlusion, unspecified
0.000 0.279 0.721
M30 Polyarteritis nodosa and related conditions
0.000 0.280 0.720
H15 Disorders of sclera
0.000 0.280 0.720
E78.6 Lipoprotein deficiency
0.000 0.280 0.719
H34.1 Central retinal artery occlusion
0.000 0.282 0.718
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.282 0.718
M65-M68 Disorders of synovium and tendon
0.000 0.282 0.718
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.283 0.717
L44 Other papulosquamous disorders
0.000 0.283 0.717
L41 Parapsoriasis
0.000 0.283 0.717
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.283 0.717
M05.8 Other seropositive rheumatoid arthritis
0.000 0.283 0.717
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.283 0.717
M05.2 Rheumatoid vasculitis
0.000 0.283 0.717
M05.1 Rheumatoid lung disease
0.000 0.283 0.717
M05.0 Felty's syndrome
0.000 0.283 0.717
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.283 0.717
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.283 0.717
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.283 0.717
L43.3 Subacute (active) lichen planus
0.000 0.283 0.717
L43.2 Lichenoid drug reaction
0.000 0.283 0.717
L43.1 Bullous lichen planus
0.000 0.283 0.717
L43.0 Hypertrophic lichen planus
0.000 0.283 0.717
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.283 0.716
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.283 0.716
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.283 0.716
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.283 0.716
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.283 0.716
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.283 0.716
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.283 0.716
M07.6 Other enteropathic arthropathies
0.000 0.284 0.716
M07.5 Arthropathy in ulcerative colitis
0.000 0.284 0.716
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.284 0.716
M07.2 Psoriatic spondylitis
0.000 0.284 0.716
M07.1 Arthritis mutilans
0.000 0.284 0.716
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.284 0.716
M07.38 Other psoriatic arthropathies (Other)
0.000 0.284 0.716
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.284 0.716
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.284 0.716
G72 Other myopathies
0.001 0.284 0.715
I08 Multiple valve diseases
0.000 0.284 0.716
E79 Disorders of purine and pyrimidine metabolism
0.000 0.285 0.715
E05.5 Thyroid crisis or storm
0.000 0.285 0.715
E05.4 Thyrotoxicosis factitia
0.000 0.285 0.715
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.285 0.715
E78.3 Hyperchylomicronaemia
0.000 0.285 0.715
E77 Disorders of glycoprotein metabolism
0.000 0.286 0.714
E76 Disorders of glycosaminoglycan metabolism
0.000 0.286 0.714
E72 Other disorders of amino-acid metabolism
0.000 0.286 0.714
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.286 0.714
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.286 0.714
G36 Other acute disseminated demyelination
0.710 0.287 0.003
E70 Disorders of aromatic amino-acid metabolism
0.000 0.288 0.711
I23 Certain current complications following acute myocardial infarction
0.000 0.289 0.711
I12.0 Hypertensive renal disease with renal failure
0.000 0.289 0.711
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.291 0.709
D64.4 Congenital dyserythropoietic anaemia
0.000 0.291 0.709
D64.3 Other sideroblastic anaemias
0.000 0.291 0.709
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.291 0.709
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.291 0.709
D64.0 Hereditary sideroblastic anaemia
0.000 0.291 0.709
G37.5 Concentric sclerosis [Balo]
0.708 0.292 0.001
G37.4 Subacute necrotising myelitis
0.708 0.292 0.001
G37.2 Central pontine myelinolysis
0.708 0.292 0.001
G37.1 Central demyelination of corpus callosum
0.708 0.292 0.001
G37.0 Diffuse sclerosis
0.708 0.292 0.001
M14.6 Neuropathic arthropathy
0.000 0.292 0.708
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.294 0.706
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.295 0.705
E13 Other specified diabetes mellitus
0.000 0.295 0.705
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.296 0.704
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.296 0.704
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.296 0.704
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.296 0.704
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.296 0.704
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.296 0.704
E15 Nondiabetic hypoglycaemic coma
0.000 0.297 0.703
H55-H59 Other disorders of eye and adnexa
0.000 0.298 0.702
E06.4 Drug-induced thyroiditis
0.000 0.300 0.700
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.300 0.700
E06.1 Subacute thyroiditis
0.000 0.300 0.700
E06.0 Acute thyroiditis
0.000 0.300 0.700
E86 Volume depletion
0.000 0.301 0.699
K72.9 Hepatic failure, unspecified
0.000 0.301 0.699
K73 Chronic hepatitis, not elsewhere classified
0.000 0.302 0.698
M35.2 Behcet's disease
0.000 0.302 0.698
D61 Other aplastic anaemias
0.000 0.304 0.696
E06.9 Thyroiditis, unspecified
0.000 0.305 0.695
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.307 0.693
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.307 0.693
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.307 0.693
E16.4 Abnormal secretion of gastrin
0.000 0.307 0.693
E16.3 Increased secretion of glucagon
0.000 0.307 0.693
H20.0 Acute and subacute iridocyclitis
0.000 0.308 0.692
G70 Myasthenia gravis and other myoneural disorders
0.002 0.309 0.689
D50-D53 Nutritional anaemias
0.000 0.309 0.691
M33 Dermatopolymyositis
0.000 0.310 0.690
H40-H42 Glaucoma
0.000 0.310 0.690
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.310 0.689
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.310 0.689
M35.5 Multifocal fibrosclerosis
0.000 0.310 0.689
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.310 0.689
H34.0 Transient retinal artery occlusion
0.000 0.311 0.689
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.316 0.684
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.000 0.317 0.683
M65 Synovitis and tenosynovitis
0.000 0.318 0.682
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.318 0.681
H43.0 Vitreous prolapse
0.000 0.321 0.679
E11.8 With unspecified complications
0.000 0.322 0.678
H35.4 Peripheral retinal degeneration
0.000 0.323 0.677
L10-L14 Bullous disorders
0.000 0.324 0.676
E14.2 Withrenal complications
0.000 0.325 0.675
G94 Other disorders of brain in diseases classified elsewhere
0.002 0.328 0.671
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.329 0.671
M06.38 Rheumatoid nodule (Other)
0.000 0.329 0.671
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.329 0.671
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.329 0.671
M06.33 Rheumatoid nodule (Forearm)
0.000 0.329 0.671
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.329 0.671
I24.8 Other forms of acute ischaemic heart disease
0.000 0.330 0.670
G53 Cranial nerve disorders in diseases classified elsewhere
0.001 0.330 0.669
E89.4 Postprocedural ovarian failure
0.000 0.330 0.670
E78.1 Pure hyperglyceridaemia
0.000 0.331 0.669
M80-M85 Disorders of bone density and structure
0.000 0.332 0.668
G71 Primary disorders of muscles
0.002 0.335 0.663
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.337 0.663
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.337 0.663
G52 Disorders of other cranial nerves
0.001 0.338 0.661
I13 Hypertensive heart and renal disease
0.000 0.338 0.662
L42 Pityriasis rosea
0.000 0.340 0.660
G56.1 Other lesions of median nerve
0.000 0.341 0.659
K75.9 Inflammatory liver disease, unspecified
0.000 0.343 0.657
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.347 0.653
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.348 0.652
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.349 0.651
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.000 0.350 0.649
G56.9 Mononeuropathy of upper limb, unspecified
0.000 0.352 0.648
K75.3 Granulomatous hepatitis, not elsewhere classified
0.000 0.353 0.647
I09 Other rheumatic heart diseases
0.000 0.354 0.646
E84 Cystic fibrosis
0.000 0.354 0.646
H20.8 Other iridocyclitis
0.000 0.355 0.645
D55-D59 Haemolytic anaemias
0.000 0.356 0.644
M65.4 Radial styloid tenosynovitis [de Quervain]
0.000 0.357 0.643
I15.9 Seconday hypertension, unspecified
0.000 0.358 0.642
E89.2 Postprocedural hypoparathyroidism
0.000 0.358 0.642
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.358 0.642
E14.4 With neurological complications
0.000 0.359 0.641
E07 Other disorders of thyroid
0.000 0.359 0.641
I22.8 Subsequent myocardial infarction of other sites
0.000 0.364 0.636
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.364 0.636
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.364 0.636
E89.5 Postprocedural testicular hypofunction
0.000 0.364 0.636
E89.1 Postprocedural hypoinsulinaemia
0.000 0.364 0.636
G56.3 Lesion of radial nerve
0.000 0.364 0.635
G96 Other disorders of central nervous system
0.001 0.366 0.633
G61 Inflammatory polyneuropathy
0.001 0.366 0.633
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.368 0.632
E73 Lactose intolerance
0.000 0.369 0.631
D63 Anaemia in chronic diseases classified elsewhere
0.000 0.369 0.631
G63 Polyneuropathy in diseases classified elsewhere
0.001 0.370 0.629
H33 Retinal detachments and breaks
0.000 0.370 0.630
G56.4 Causalgia
0.000 0.371 0.629
I25.4 Coronary artery aneurysm
0.000 0.372 0.628
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.626 0.373 0.001
H21 Other disorders of iris and ciliary body
0.000 0.375 0.625
M82 Osteoporosis in diseases classified elsewhere
0.000 0.376 0.624
E83 Disorders of mineral metabolism
0.529 0.377 0.094
I08.0 Disorders of both mitral and aortic valves
0.000 0.378 0.622
E03.8 Other specified hypothyroidism
0.000 0.380 0.620
M00-M03 Infectious arthropathies
0.000 0.382 0.618
M80 Osteoporosis with pathological fracture
0.000 0.384 0.616
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.385 0.615
H30.8 Other chorioretinal inflammations
0.000 0.386 0.614
H30.2 Posterior cyclitis
0.000 0.386 0.614
H30.1 Disseminated chorioretinal inflammation
0.000 0.386 0.614
H30.0 Focal chorioretinal inflammation
0.000 0.386 0.614
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.388 0.612
E50-E64 Other nutritional deficiencies
0.000 0.388 0.612
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.000 0.390 0.610
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.390 0.610
G98 Other disorders of nervous system, not elsewhere classified
0.002 0.390 0.608
E88 Other metabolic disorders
0.000 0.391 0.609
I15.8 Other secondary hypertension
0.000 0.391 0.609
I15.2 Hypertension secondary to endocrine disorders
0.000 0.391 0.609
I15.0 Renovascular hypertension
0.000 0.391 0.609
G72.0 Drug-induced myopathy
0.001 0.392 0.608
E16.1 Other hypoglycaemia
0.000 0.392 0.607
I24.1 Dressler's syndrome
0.000 0.393 0.607
K73.9 Chronic hepatitis, unspecified
0.000 0.395 0.605
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.395 0.605
K90.3 Pancreatic steatorrhoea
0.000 0.395 0.605
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.395 0.605
K90.1 Tropical sprue
0.000 0.395 0.605
L50-L54 Urticaria and erythema
0.000 0.396 0.604
H59 Postprocedural disorders of eye and adnexa, not elsewhere classified
0.000 0.397 0.603
H33.2 Serous retinal detachment
0.000 0.401 0.599
G70.0 Myasthenia gravis
0.000 0.402 0.598
M80.9 Unspecified osteoporosis with pathological fracture
0.000 0.403 0.597
H15.1 Episcleritis
0.000 0.404 0.596
G59.8 Other mononeuropathies in diseases classified elsewhere
0.001 0.405 0.594
M82.1 Osteoporosis in endocrine disorders
0.000 0.407 0.593
M24 Other specific joint derangements
0.000 0.409 0.591
E03.1 Congenital hypothyroidism without goitre
0.000 0.410 0.590
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.411 0.589
M65.43 Radial styloid tenosynovitis [de Quervain] (Forearm)
0.000 0.411 0.589
G94.2 Hydrocephalus in other diseases classified elsewhere
0.001 0.411 0.588
H35.2 Other proliferative retinopathy
0.000 0.412 0.588
M35.8 Other specified systemic involvement of connective tissue
0.000 0.412 0.588
M32 Systemic lupus erythematosus
0.000 0.413 0.586
M65.8 Other synovitis and tenosynovitis
0.000 0.415 0.585
M34.0 Progressive systemic sclerosis
0.000 0.415 0.584
K77 Liver disorders in diseases classified elsewhere
0.000 0.416 0.584
K71 Toxic liver disease
0.000 0.416 0.584
H20.2 Lens-induced iridocyclitis
0.000 0.417 0.583
M60-M63 Disorders of muscles
0.000 0.417 0.583
M91-M94 Chondropathies
0.000 0.418 0.582
H20.1 Chronic iridocyclitis
0.000 0.418 0.582
G73 Disorders of myoneural junction and muscle in diseases classified elsewhere
0.003 0.418 0.579
D61.1 Drug-induced aplastic anaemia
0.000 0.419 0.581
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.419 0.581
K75.2 Nonspecific reactive hepatitis
0.000 0.420 0.580
K75.1 Phlebitis of portal vein
0.000 0.420 0.580
L40.3 Pustulosis palmaris et plantaris
0.000 0.422 0.577
H15.8 Other disorders of sclera
0.000 0.422 0.577
M25 Other joint disorders, not elsewhere classified
0.000 0.423 0.577
G71.0 Muscular dystrophy
0.001 0.423 0.576
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.425 0.575
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.425 0.575
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.425 0.575
E74.2 Disorders of galactose metabolism
0.000 0.425 0.575
E74.1 Disorders of fructose metabolism
0.000 0.425 0.575
E74.0 Glycogen storage disease
0.000 0.425 0.575
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders
0.000 0.426 0.573
M14.4 Arthropathy in amyloidosis
0.000 0.426 0.573
M14.3 Lipoid dermatoarthritis
0.000 0.426 0.573
M14.1 Crystal arthropathy in other metabolic disorders
0.000 0.426 0.573
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders
0.000 0.426 0.573
G90 Disorders of autonomic nervous system
0.001 0.427 0.572
M12.3 Palindromic rheumatism
0.000 0.427 0.573
M34.9 Systemic sclerosis, unspecified
0.000 0.428 0.572
M13 Other arthritis
0.000 0.431 0.569
K74.4 Secondary biliary cirrhosis
0.000 0.431 0.569
K74.2 Hepatic fibrosis with hepatic sclerosis
0.000 0.431 0.569
K74.1 Hepatic sclerosis
0.000 0.431 0.569
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.431 0.569
M25.4 Effusion of joint
0.000 0.435 0.565
K75.8 Other specified inflammatory liver diseases
0.000 0.435 0.565
I08.1 Disorders of both mitral and tricuspid valves
0.000 0.437 0.563
G92 Toxic encephalopathy
0.002 0.437 0.561
I07 Rheumatic tricuspid valve diseases
0.000 0.437 0.563
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)
0.000 0.438 0.562
D51 Vitamin B12 deficiency anaemia
0.000 0.438 0.562
M34.8 Other forms of systemic sclerosis
0.000 0.440 0.560
G72.9 Myopathy, unspecified
0.001 0.441 0.558
I11 Hypertensive heart disease
0.000 0.441 0.558
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.442 0.557
G61.0 Guillain-Barre syndrome
0.000 0.443 0.557
M25.46 Effusion of joint (Lower leg)
0.000 0.443 0.557
G99 Other disorders of nervous system in diseases classified elsewhere
0.002 0.445 0.552
G72.8 Other specified myopathies
0.001 0.446 0.554
I83 Varicose veins of lower extremities
0.553 0.447 0.000
M80.98 Unspecified osteoporosis with pathological fracture (Other)
0.000 0.448 0.552
M82.11 Osteoporosis in endocrine disorders (Shoulder region)
0.000 0.449 0.551
G63.2 Diabetic polyneuropathy
0.000 0.450 0.550
M65.44 Radial styloid tenosynovitis [de Quervain] (Hand)
0.000 0.450 0.550
M49.5 Collapsed vertebra in diseases classified elsewhere
0.000 0.450 0.549
G53.0 Postzoster neuralgia
0.001 0.451 0.549
H35.6 Retinal haemorrhage
0.000 0.451 0.549
M11 Other crystal arthropathies
0.000 0.451 0.549
E46 Unspecified protein-energy malnutrition
0.000 0.451 0.549
L56.8 Other specified acute skin changes due to ultraviolet radiation
0.000 0.452 0.548
M65.84 Other synovitis and tenosynovitis (Hand)
0.000 0.453 0.546
G91.3 Posttraumatic hydrocephalus, unspecified
0.001 0.454 0.545
M30.0 Polyarteritis nodosa
0.000 0.455 0.545

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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