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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs112308695
log Bayes Factor = 21.2781
Chromosome 21   position 18,297,682  (GRCh37) Explore rs112308695 on Ensembl!
Variant rs112308695 is part of Cluster X0049

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
M15-M19 Arthrosis
1.000 0.000 0.000
Chapter XIV Diseases of the genitourinary system
1.000 0.000 0.000
M19 Other arthrosis
0.998 0.002 0.000
I30-I52 Other forms of heart disease
0.997 0.003 0.000
M19.9 Arthrosis, unspecified
0.996 0.004 0.000
Chapter VI Diseases of the nervous system
0.995 0.005 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.992 0.008 0.000
N80-N98 Noninflammatory disorders of female genital tract
0.992 0.008 0.000
Chapter XX External causes of morbidity and mortality
0.989 0.011 0.000
N17-N19 Renal failure
0.988 0.012 0.000
G90-G99 Other disorders of the nervous system
0.984 0.016 0.000
I20-I25 Ischaemic heart diseases
0.976 0.024 0.000
E00-E07 Disorders of thyroid gland
0.975 0.025 0.000
M16 Coxarthrosis [arthrosis of hip]
0.972 0.028 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.971 0.029 0.000
N17 Acute renal failure
0.969 0.031 0.000
Chapter VII Diseases of the eye and adnexa
0.967 0.033 0.000
E10-E14 Diabetes mellitus
0.962 0.038 0.000
M19.97 Arthrosis, unspecified (Ankle and foot)
0.956 0.044 0.000
S60-S69 Injuries to the wrist and hand
0.956 0.044 0.000
Chapter V Mental and behavioural disorders
0.956 0.044 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.956 0.044 0.000
N30-N39 Other diseases of urinary system
0.956 0.044 0.000
N17.9 Acute renal failure, unspecified
0.956 0.044 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.954 0.046 0.000
G93 Other disorders of brain
0.954 0.046 0.000
E20-E35 Disorders of other endocrine glands
0.953 0.047 0.000
N81 Female genital prolapse
0.951 0.049 0.000
Chapter XXI Factors influencing health status and contact with health services
0.943 0.057 0.000
E70-E90 Metabolic disorders
0.942 0.058 0.000
M18 Arthrosis of first carpometacarpal joint
0.941 0.059 0.000
M16.9 Coxarthrosis, unspecified
0.941 0.059 0.000
N95 Menopausal and other perimenopausal disorders
0.938 0.062 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.937 0.063 0.000
M19.99 Arthrosis, unspecified (Site unspecified)
0.934 0.066 0.000
G40-G47 Episodic and paroxysmal disorders
0.930 0.070 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.925 0.075 0.000
N92 Excessive, frequent and irregular menstruation
0.924 0.076 0.000
S00-S09 Injuries to the head
0.921 0.079 0.000
E03 Other hypothyroidism
0.915 0.084 0.000
I44 Atrioventricular and left bundle-branch block
0.913 0.087 0.000
I45 Other conduction disorders
0.912 0.088 0.000
N31 Neuromuscular dysfunction of bladder, not elsewhere classified
0.910 0.090 0.000
G47 Sleep disorders
0.909 0.091 0.000
I60-I69 Cerebrovascular diseases
0.909 0.091 0.000
N81.6 Rectocele
0.907 0.093 0.000
Chapter I Certain infectious and parasitic diseases
0.905 0.095 0.000
N18 Chronic renal failure
0.899 0.101 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.898 0.102 0.000
I31 Other diseases of pericardium
0.895 0.105 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.894 0.106 0.000
G47.3 Sleep apnoea
0.892 0.108 0.000
E10 Insulin-dependent diabetes mellitus
0.892 0.108 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.889 0.111 0.000
H30-H36 Disorders of choroid and retina
0.889 0.111 0.000
E11 Non-insulin-dependent diabetes mellitus
0.889 0.111 0.000
W00-W19 Falls
0.883 0.117 0.000
N00-N08 Glomerular diseases
0.880 0.120 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.878 0.122 0.000
Z40-Z54 Persons encountering health services for specific procedures and health care
0.878 0.122 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.876 0.124 0.000
M40-M43 Deforming dorsopathies
0.876 0.124 0.000
N60-N64 Disorders of breast
0.873 0.127 0.000
L03 Cellulitis
0.873 0.127 0.000
E03.9 Hypothyroidism, unspecified
0.873 0.127 0.000
Chapter VIII Diseases of the ear and mastoid process
0.871 0.129 0.000
H43-H45 Disorders of vitreous body and globe
0.871 0.129 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.868 0.132 0.000
M65-M68 Disorders of synovium and tendon
0.867 0.133 0.000
R40 Somnolence, stupor and coma
0.865 0.135 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.858 0.142 0.000
N95.0 Postmenopausal bleeding
0.857 0.143 0.000
N81.1 Cystocele
0.856 0.144 0.000
Y52 Agents primarily affecting the cardiovascular system
0.855 0.145 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.851 0.148 0.000
I05-I09 Chronic rheumatic heart diseases
0.851 0.149 0.000
I20 Angina pectoris
0.851 0.149 0.000
I50 Heart failure
0.849 0.151 0.000
N94 Pain and other conditions associated with female genital organs and menstrual cycle
0.848 0.152 0.000
I21 Acute myocardial infarction
0.847 0.153 0.000
N92.1 Excessive and frequent menstruation with irregular cycle
0.846 0.154 0.000
N84 Polyp of female genital tract
0.845 0.155 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.844 0.156 0.000
N87 Dysplasia of cervix uteri
0.844 0.156 0.000
N81.3 Complete uterovaginal prolapse
0.840 0.160 0.000
I25 Chronic ischaemic heart disease
0.839 0.161 0.000
G99.2 Myelopathy in diseases classified elsewhere
0.837 0.163 0.000
G93.8 Other specified disorders of brain
0.837 0.163 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.833 0.167 0.000
E27 Other disorders of adrenal gland
0.831 0.169 0.000
M19.91 Arthrosis, unspecified (Shoulder region)
0.831 0.169 0.000
N30 Cystitis
0.827 0.173 0.000
Z53 Persons encountering health services for specifie procedures, not carried out
0.827 0.173 0.000
M18.9 Arthrosis of first carpometacarpal joint, unspecified
0.826 0.174 0.000
S68 Traumatic amputation of wrist and hand
0.826 0.174 0.000
L02 Cutaneous abscess, furuncle and carbuncle
0.826 0.174 0.000
S01 Open wound of head
0.825 0.175 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.824 0.176 0.000
E87.2 Acidosis
0.824 0.176 0.000
E10.9 Without complications
0.824 0.176 0.000
A30-A49 Other bacterial diseases
0.824 0.176 0.000
M19.96 Arthrosis, unspecified-Lower leg
0.822 0.178 0.000
R41.0 Disorientation, unspecified
0.822 0.178 0.000
I35 Nonrheumatic aortic valve disorders
0.822 0.178 0.000
R40.2 Coma, unspecified
0.822 0.178 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.822 0.178 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.819 0.181 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.817 0.183 0.000
L03.1 Cellulitis of other parts of limb
0.814 0.186 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.814 0.186 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.813 0.187 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.811 0.189 0.000
I95 Hypotension
0.811 0.189 0.000
N95.2 Postmenopausal atrophic vaginitis
0.810 0.190 0.000
H53-H54 Visual disturbances and blindness
0.807 0.193 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.807 0.193 0.000
Y43 Primarily systemic agents
0.807 0.193 0.000
H43 Disorders of vitreous body
0.805 0.195 0.000
M19.0 Primary arthrosis of other joints
0.804 0.196 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.803 0.197 0.000
G93.6 Cerebral oedema
0.802 0.198 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.802 0.198 0.000
Chapter II Neoplasms
0.802 0.198 0.000
I51 Complications and ill-defined descriptions of heart disease
0.801 0.199 0.000
F10 Mental and behavioural disorders due to use of alcohol
0.801 0.199 0.000
I24 Other acute ischaemic heart diseases
0.801 0.199 0.000
E78.5 Hyperlipidaemia, unspecified
0.800 0.200 0.000
E06 Thyroiditis
0.797 0.203 0.000
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral
0.797 0.203 0.000
R00 Abnormalities of heart beat
0.796 0.204 0.000
Z45 Adjustment and management of implanted device
0.795 0.205 0.000
M65 Synovitis and tenosynovitis
0.794 0.206 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.794 0.206 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.793 0.207 0.000
I33 Acute and subacute endocarditis
0.793 0.207 0.000
N31.2 Flaccid neuropathic bladder, not elsewhere classified
0.793 0.207 0.000
W19 Unspecified fall
0.791 0.209 0.000
M19.98 Arthrosis, unspecified (Other)
0.791 0.209 0.000
S50-S59 Injuries to the elbow and forearm
0.790 0.210 0.000
N31.8 Other neuromuscular dysfunction of bladder
0.789 0.211 0.000
S09 Other and unspecified injuries of head
0.789 0.211 0.000
R47-R49 Symptoms and signs involving speech and voice
0.788 0.212 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.788 0.212 0.000
M16.3 Other dysplastic coxarthrosis
0.787 0.213 0.000
M16.0 Primary coxarthrosis, bilateral
0.785 0.215 0.000
G70-G73 Diseases of myoneural junction and muscle
0.785 0.215 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.784 0.216 0.000
G93.0 Cerebral cysts
0.784 0.216 0.000
S70-S79 Injuries to the hip and thigh
0.783 0.216 0.000
H35 Other retinal disorders
0.782 0.218 0.000
N18.5 Chronic kidney disease, stage 5
0.782 0.218 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.781 0.219 0.000
R00.1 Bradycardia, unspecified
0.780 0.220 0.000
N60 Benign mammary dysplasia
0.779 0.221 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.779 0.221 0.000
A00-A09 Intestinal infectious diseases
0.778 0.222 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.777 0.223 0.000
M50-M54 Other dorsopathies
0.777 0.223 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.775 0.225 0.000
G93.1 Anoxic brain damage, not elsewhere classified
0.774 0.226 0.000
M05-M14 Inflammatory polyarthropathies
0.774 0.226 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.774 0.226 0.000
S60 Superficial injury of wrist and hand
0.774 0.226 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.774 0.226 0.000
E16 Other disorders of pancreatic internal secretion
0.773 0.227 0.000
I45.1 Other and unspecified right bundle-branch block
0.773 0.227 0.000
Chapter XXII Codes for special purposes
0.772 0.228 0.000
M19.94 Arthrosis, unspecified (Hand)
0.771 0.229 0.000
N84.0 Polyp of corpus uteri
0.771 0.229 0.000
I44.7 Left bundle-branch block, unspecified
0.771 0.229 0.000
N92.0 Excessive and frequent menstruation with regular cycle
0.770 0.230 0.000
E29 Testicular dysfunction
0.769 0.231 0.000
Z53.8 Procedure not carried out for other reasons
0.768 0.232 0.000
N95.1 Menopausal and female climacteric states
0.767 0.233 0.000
I31.3 Pericardial effusion (noninflammatory)
0.766 0.234 0.000
M60-M63 Disorders of muscles
0.765 0.235 0.000
M19.95 Arthrosis, unspecified (Pelvic region and thigh)
0.763 0.236 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.763 0.237 0.000
M18.1 Other primary arthrosis of first carpometacarpal joint
0.763 0.237 0.000
I69 Sequelae of cerebrovascular disease
0.762 0.238 0.000
M86-M90 Other osteopathies
0.762 0.238 0.000
S66.3 Injury of extensor muscle and tendon of other finger at wrist and hand level
0.762 0.238 0.000
M43 Other deforming dorsopathies
0.761 0.239 0.000
S02 Fracture of skull and facial bones
0.760 0.240 0.000
I44.1 Atrioventricular block, second degree
0.760 0.240 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.760 0.240 0.000
N90 Other noninflammatory disorders of vulva and perineum
0.759 0.240 0.000
H43.8 Other disorders of vitreous body
0.758 0.242 0.000
S40-S49 Injuries to the shoulder and upper arm
0.758 0.242 0.000
Y40 Systemic antibiotics
0.757 0.243 0.000
I61 Intracerebral haemorrhage
0.757 0.243 0.000
H60-H62 Diseases of external ear
0.757 0.243 0.000
L97 Ulcer of lower limb, not elsewhere classified
0.755 0.245 0.000
N31.9 Neuromuscular dysfunction of bladder, unspecified
0.755 0.245 0.000
I26 Pulmonary embolism
0.754 0.246 0.000
G93.9 Disorder of brain, unspecified
0.754 0.246 0.000
D10-D36 Benign neoplasms
0.753 0.247 0.000
Z50 Care involving use of rehabilitation procedures
0.752 0.248 0.000
I45.6 Preexcitation syndrome
0.752 0.248 0.000
F80-F89 Disorders of psychological development
0.752 0.248 0.000
Z45.2 Adjustment and management of vascular access device
0.752 0.248 0.000
A41 Other septicaemia
0.751 0.249 0.000
N92.4 Excessive bleeding in the premenopausal period
0.751 0.249 0.000
I31.9 Disease of pericardium, unspecified
0.750 0.250 0.000
N02 Recurrent and persistent haematuria
0.750 0.250 0.000
I25.2 Old myocardial infarction
0.750 0.250 0.000
I51.8 Other ill-defined heart diseases
0.749 0.251 0.000
S67 Crushing injury of wrist and hand
0.749 0.251 0.000
F30-F39 Mood [affective] disorders
0.748 0.252 0.000
E83 Disorders of mineral metabolism
0.747 0.253 0.000
I20.1 Angina pectoris with documented spasm
0.747 0.253 0.000
E04 Other non-toxic goitre
0.747 0.253 0.000
I08 Multiple valve diseases
0.747 0.253 0.000
E87.5 Hyperkalaemia
0.746 0.254 0.000
G95 Other diseases of spinal cord
0.745 0.255 0.000
H10-H13 Disorders of conjunctiva
0.745 0.255 0.000
N39 Other disorders of urinary system
0.744 0.256 0.000
B25-B34 Other viral diseases
0.744 0.256 0.000
E27.1 Primary adrenocortical insufficiency
0.744 0.256 0.000
I67 Other cerebrovascular diseases
0.743 0.257 0.000
H55-H59 Other disorders of eye and adnexa
0.743 0.257 0.000
N32 Other disorders of bladder
0.742 0.258 0.000
I44.3 Other and unspecified atrioventricular block
0.741 0.259 0.000
V10-V19 Pedal cyclist injured in transport accident
0.741 0.259 0.000
N18.9 Chronic renal failure, unspecified
0.740 0.260 0.000
E07 Other disorders of thyroid
0.738 0.262 0.000
I47 Paroxysmal tachycardia
0.738 0.262 0.000
M19.93 Arthrosis, unspecified (Forearm)
0.737 0.263 0.000
L08 Other local infections of skin and subcutaneous tissue
0.737 0.263 0.000
L82 Seborrhoeic keratosis
0.736 0.264 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.736 0.264 0.000
E11.5 With peripheral circulatory complications
0.735 0.265 0.000
Z49 Care involving dialysis
0.735 0.265 0.000
E11.3 With ophthalmic complications
0.734 0.266 0.000
M80-M85 Disorders of bone density and structure
0.733 0.266 0.000
S68.1 Traumatic amputation of other single finger (complete)(partial)
0.733 0.267 0.000
L20-L30 Dermatitis and eczema
0.731 0.269 0.000
I45.5 Other specified heart block
0.730 0.270 0.000
S61 Open wound of wrist and hand
0.730 0.270 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.728 0.272 0.000
I95.9 Hypotension, unspecified
0.728 0.272 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.727 0.273 0.000
I10-I15 Hypertensive diseases
0.727 0.273 0.000
Y52.2 Other antidysrhythmic drugs, not elsewhere classified
0.727 0.273 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.727 0.273 0.000
I35.0 Aortic (valve) stenosis
0.727 0.273 0.000
G40 Epilepsy
0.727 0.273 0.000
L50-L54 Urticaria and erythema
0.726 0.274 0.000
M70-M79 Other soft tissue disorders
0.723 0.277 0.000
L02.4 Cutaneous abscess, furuncle and carbuncle of limb
0.723 0.277 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.722 0.278 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.722 0.278 0.000
N94.1 Dyspareunia
0.721 0.278 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.722 0.278 0.000
I38 Endocarditis, valve unspecified
0.720 0.280 0.000
E13 Other specified diabetes mellitus
0.720 0.280 0.000
T79-T79 Certain early complications of trauma
0.719 0.280 0.000
S90-S99 Injuries to the ankle and foot
0.719 0.281 0.000
N81.9 Female genital prolapse, unspecified
0.719 0.281 0.000
E21.3 Hyperparathyroidism, unspecified
0.718 0.282 0.000
N92.6 Irregular menstruation, unspecified
0.717 0.283 0.000
E11.6 With other specified complications
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
M91-M94 Chondropathies
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
E40-E46 Malnutrition
0.717 0.283 0.000
M15 Polyarthrosis
0.717 0.283 0.000
Y44 Agents primarily affecting blood constituents
0.717 0.283 0.000
Z95 Presence of cardiac and vascular implants and grafts
0.716 0.284 0.000
T66-T78 Other and unspecified effects of external causes
0.716 0.284 0.000
M19.8 Other specified arthrosis
0.715 0.284 0.000
M19.2 Other secondary arthrosis
0.715 0.284 0.000
M19.1 Posttraumatic arthrosis of other joints
0.715 0.284 0.000
I52 Other heart disorders in diseases classified elsewhere
0.715 0.285 0.000
I48 Atrial fibrillation and flutter
0.715 0.285 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.715 0.285 0.000
I41 Myocarditis in diseases classified elsewhere
0.715 0.285 0.000
I40 Acute myocarditis
0.715 0.285 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.715 0.285 0.000
I37 Pulmonary valve disorders
0.715 0.285 0.000
I36 Nonrheumatic tricuspid valve disorders
0.715 0.285 0.000
I32 Pericarditis in diseases classified elsewhere
0.715 0.285 0.000
I30 Acute pericarditis
0.715 0.285 0.000
M19.92 Arthrosis, unspecified (Upper arm)
0.714 0.286 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.714 0.286 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.714 0.286 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.714 0.286 0.000
I22 Subsequent myocardial infarction
0.713 0.286 0.000
N64 Other disorders of breast
0.713 0.287 0.000
G30-G32 Other degenerative diseases of the nervous system
0.711 0.288 0.000
T33-T35 Frostbite
0.711 0.289 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.711 0.289 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.711 0.289 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.711 0.289 0.000
T00-T07 Injuries involving multiple body regions
0.711 0.289 0.000
S10-S19 Injuries to the neck
0.711 0.289 0.000
N98 Complications associated with artificial fertilisation
0.711 0.289 0.000
N91 Absent, scanty and rare menstruation
0.711 0.289 0.000
N82 Fistulae involving female genital tract
0.711 0.289 0.000
N96 Habitual aborter
0.711 0.289 0.000
Z60 Problems related to social environment
0.711 0.289 0.000
R41.3 Other amnesia
0.711 0.289 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.711 0.289 0.000
E10.1 With ketoacidosis
0.710 0.290 0.000
M19.90 Arthrosis, unspecified (Multiple sites)
0.709 0.291 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.709 0.291 0.000
Y35-Y36 Legal intervention and operations of war
0.709 0.291 0.000
Y10-Y34 Event of undetermined intent
0.709 0.291 0.000
Y00-Y09 Assault
0.709 0.291 0.000
X85-X99 Assault
0.709 0.291 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.709 0.291 0.000
X50-X57 Overexertion, travel and privation
0.709 0.291 0.000
X30-X39 Exposure to forces of nature
0.709 0.291 0.000
X20-X29 Contact with venomous animals and plants
0.709 0.291 0.000
X10-X19 Contact with heat and hot substances
0.709 0.291 0.000
X00-X09 Exposure to smoke, fire and flames
0.709 0.291 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.709 0.291 0.000
W75-W84 Other accidental threats to breathing
0.709 0.291 0.000
W65-W74 Accidental drowning and submersion
0.709 0.291 0.000
W50-W64 Exposure to animate mechanical forces
0.709 0.291 0.000
V98-V99 Other and unspecified transport accidents
0.709 0.291 0.000
V95-V97 Air and space transport accidents
0.709 0.291 0.000
V90-V94 Water transport accidents
0.709 0.291 0.000
V80-V89 Other land transport accidents
0.709 0.291 0.000
V70-V79 Bus occupant injured in transport accident
0.709 0.291 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.709 0.291 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.709 0.291 0.000
V40-V49 Car occupant injured in transport accident
0.709 0.291 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.709 0.291 0.000
V20-V29 Motorcycle rider injured in transport accident
0.709 0.291 0.000
V01-V09 Pedestrian injured in transport accident
0.709 0.291 0.000
I42 Cardiomyopathy
0.709 0.291 0.000
E23 Hypofunction and other disorders of pituitary gland
0.707 0.293 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.706 0.294 0.000
G96 Other disorders of central nervous system
0.706 0.294 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.706 0.294 0.000
G91 Hydrocephalus
0.706 0.294 0.000
G90 Disorders of autonomic nervous system
0.706 0.294 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.706 0.294 0.000
G92 Toxic encephalopathy
0.706 0.294 0.000
E16.2 Hypoglycaemia, unspecified
0.705 0.295 0.000
I46 Cardiac arrest
0.705 0.295 0.000
Y52.1 Calcium-channel blockers
0.705 0.295 0.000
A41.9 Septicaemia, unspecified
0.704 0.296 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.704 0.296 0.000
A09 Diarrhoea and gastro-enteritis of presumed infectious origin
0.704 0.296 0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.703 0.297 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.703 0.297 0.000
N03 Chronic nephritic syndrome
0.703 0.297 0.000
R26 Abnormalities of gait and mobility
0.702 0.297 0.000
H34 Retinal vascular occlusions
0.702 0.298 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.701 0.299 0.000
L40-L45 Papulosquamous disorders
0.700 0.299 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.700 0.299 0.000
N18.0 End-stage renal disease
0.700 0.300 0.000
I23 Certain current complications following acute myocardial infarction
0.700 0.300 0.000
E65-E68 Obesity and other hyperalimentation
0.700 0.300 0.000
N30.0 Acute cystitis
0.699 0.300 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.699 0.301 0.000
E00 Congenital iodine-deficiency syndrome
0.699 0.301 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.699 0.301 0.000
S62 Fracture at wrist and hand level
0.699 0.301 0.000
H54 Blindness and low vision
0.698 0.302 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.697 0.303 0.000
M16.7 Other secondary coxarthrosis
0.697 0.303 0.000
M16.6 Other secondary coxarthrosis, bilateral
0.697 0.303 0.000
M16.5 Other posttraumatic coxarthrosis
0.697 0.303 0.000
M16.4 Posttraumatic coxarthrosis, bilateral
0.697 0.303 0.000
M16.2 Coxarthrosis resulting from dysplasia, bilateral
0.697 0.303 0.000
H65-H75 Diseases of middle ear and mastoid
0.696 0.303 0.000
L10-L14 Bullous disorders
0.696 0.304 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.696 0.304 0.000
X60-X84 Intentional self-harm
0.695 0.304 0.000
W19.9 Unspecified place
0.695 0.305 0.000
N17.8 Other acute renal failure
0.695 0.305 0.000
N17.2 Acute renal failure with medullary necrosis
0.695 0.305 0.000
N17.1 Acute renal failure with acute cortical necrosis
0.695 0.305 0.000
N17.0 Acute renal failure with tubular necrosis
0.695 0.305 0.000
N97 Female infertility
0.695 0.305 0.000
H36 Retinal disorders in diseases classified elsewhere
0.694 0.306 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.694 0.306 0.000
S09.9 Unspecified injury of head
0.694 0.306 0.000
I27 Other pulmonary heart diseases
0.693 0.306 0.000
M65.9 Synovitis and tenosynovitis, unspecified
0.693 0.307 0.000
Z72 Problems related to lifestyle
0.693 0.307 0.000
Z50.8 Care involving use of rehabilitation procedures
0.692 0.308 0.000
S01.8 Open wound of other parts of head
0.691 0.309 0.000
E12 Malnutrition-related diabetes mellitus
0.689 0.311 0.000
E11.4 With neurological complications
0.689 0.311 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.689 0.311 0.000
I50.0 Congestive heart failure
0.688 0.312 0.000
S69 Other and unspecified injuries of wrist and hand
0.686 0.314 0.000
S65 Injury of blood vessels at wrist and hand level
0.686 0.314 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.686 0.314 0.000
F99-F99 Unspecified mental disorder
0.685 0.315 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.685 0.315 0.000
F70-F79 Mental retardation
0.685 0.315 0.000
F60-F69 Disorders of adult personality and behaviour
0.685 0.315 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.685 0.315 0.000
N37 Urethral disorders in diseases classified elsewhere
0.685 0.315 0.000
N34 Urethritis and urethral syndrome
0.685 0.315 0.000
N33 Bladder disorders in diseases classified elsewhere
0.685 0.315 0.000
Z93 Artificial opening status
0.685 0.315 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.684 0.316 0.000
Y59 Other and unspecified vaccines and biological substances
0.684 0.316 0.000
Y58 Bacterial vaccines
0.684 0.316 0.000
Y57 Other and unspecified drugs and medicaments
0.684 0.316 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.684 0.316 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.684 0.316 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.684 0.316 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.684 0.316 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.684 0.316 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.684 0.316 0.000
Y48 Anaesthetics and therapeutic gases
0.684 0.316 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.684 0.316 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.684 0.316 0.000
Z53.9 Procedure not carried out, unspecified reason
0.684 0.316 0.000
G93.7 Reye's syndrome
0.684 0.316 0.000
G93.5 Compression of brain
0.684 0.316 0.000
G93.4 Encephalopathy, unspecified
0.684 0.316 0.000
G93.2 Benign intracranial hypertension
0.684 0.316 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.683 0.317 0.000
E34 Other endocrine disorders
0.683 0.317 0.000
E32 Diseases of thymus
0.683 0.317 0.000
E31 Polyglandular dysfunction
0.683 0.317 0.000
E30 Disorders of puberty, not elsewhere classified
0.683 0.317 0.000
E28 Ovarian dysfunction
0.683 0.317 0.000
E26 Hyperaldosteronism
0.683 0.317 0.000
E25 Adrenogenital disorders
0.683 0.317 0.000
E24 Cushing's syndrome
0.683 0.317 0.000
E22 Hyperfunction of pituitary gland
0.683 0.317 0.000
E20 Hypoparathyroidism
0.683 0.317 0.000
F10.1 Harmful use
0.683 0.317 0.000
R73 Elevated blood glucose level
0.682 0.317 0.000
M41 Scoliosis
0.682 0.318 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.682 0.318 0.000
N81.0 Female urethrocele
0.682 0.318 0.000
G47.9 Sleep disorder, unspecified
0.679 0.320 0.000
W20-W49 Exposure to inanimate mechanical forces
0.679 0.321 0.000
M43.1 Spondylolisthesis
0.679 0.321 0.000
Z96 Presence of other functional implants
0.679 0.321 0.000
I34 Nonrheumatic mitral valve disorders
0.678 0.322 0.000
M65.3 Trigger finger
0.678 0.322 0.000
E87.7 Fluid overload
0.678 0.322 0.000
I50.9 Heart failure, unspecified
0.678 0.322 0.000
S01.1 Open wound of eyelid and periocular area
0.677 0.323 0.000
F10.2 Dependence syndrome
0.677 0.323 0.000
I62 Other nontraumatic intracranial haemorrhage
0.677 0.323 0.000
E85 Amyloidosis
0.676 0.324 0.000
E84 Cystic fibrosis
0.676 0.324 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.676 0.324 0.000
E79 Disorders of purine and pyrimidine metabolism
0.676 0.324 0.000
E77 Disorders of glycoprotein metabolism
0.676 0.324 0.000
E76 Disorders of glycosaminoglycan metabolism
0.676 0.324 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.676 0.324 0.000
E74 Other disorders of carbohydrate metabolism
0.676 0.324 0.000
E73 Lactose intolerance
0.676 0.324 0.000
E72 Other disorders of amino-acid metabolism
0.676 0.324 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.676 0.324 0.000
E70 Disorders of aromatic amino-acid metabolism
0.676 0.324 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.676 0.324 0.000
M18.5 Other secondary arthrosis of first carpometacarpal joint
0.675 0.325 0.000
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral
0.675 0.325 0.000
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint
0.675 0.325 0.000
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral
0.675 0.325 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.674 0.326 0.000
L03.9 Cellulitis, unspecified
0.673 0.327 0.000
N95.9 Menopausal and perimenopausal disorder, unspecified
0.673 0.327 0.000
N95.3 States associated with artificial menopause
0.673 0.327 0.000
I44.2 Atrioventricular block, complete
0.672 0.328 0.000
C15-C26 Malignant neoplasms of digestive organs
0.672 0.328 0.000
L04 Acute lymphadenitis
0.672 0.328 0.000
L01 Impetigo
0.672 0.328 0.000
L00 Staphylococcal scalded skin syndrome
0.672 0.328 0.000
L89 Decubitus ulcer
0.672 0.328 0.000
N61 Inflammatory disorders of breast
0.671 0.328 0.000
Z96.6 Presence of orthopaedic joint implants
0.672 0.328 0.000
S06 Intracranial injury
0.671 0.329 0.000
E06.3 Autoimmune thyroiditis
0.670 0.330 0.000
N18.4 Chronic kidney disease, stage 4
0.669 0.331 0.000
N87.0 Mild cervical dysplasia
0.668 0.332 0.000
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.667 0.333 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.667 0.333 0.000
G44 Other headache syndromes
0.667 0.333 0.000
G41 Status epilepticus
0.667 0.333 0.000
L03.0 Cellulitis of finger and toe
0.665 0.335 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.665 0.335 0.000
D23 Other benign neoplasms of skin
0.665 0.335 0.000
N39.4 Other specified urinary incontinence
0.664 0.336 0.000
I98 Other disorders of circulatory system in diseases classified elsewhere
0.664 0.336 0.000
R46 Symptoms and signs involving appearance and behaviour
0.663 0.336 0.000
R43 Disturbances of smell and taste
0.663 0.336 0.000
N92.5 Other specified irregular menstruation
0.663 0.337 0.000
N92.2 Excessive menstruation at puberty
0.663 0.337 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.662 0.338 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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