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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs112475278
log Bayes Factor = 12.7647
Chromosome 3   position 103,347,707  (GRCh37) Explore rs112475278 on Ensembl!
Variant rs112475278 is part of Cluster X0258

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
M20-M25 Other joint disorders
1.000 0.000 0.000
Chapter XIV Diseases of the genitourinary system
0.999 0.001 0.000
M45-M49 Spondylopathies
0.998 0.002 0.000
N93 Other abnormal uterine and vaginal bleeding
0.998 0.002 0.000
N80-N98 Noninflammatory disorders of female genital tract
0.997 0.003 0.000
Chapter IX Diseases of the circulatory system
0.997 0.003 0.000
N93.0 Postcoital and contact bleeding
0.996 0.004 0.000
I30-I52 Other forms of heart disease
0.994 0.006 0.000
Chapter VI Diseases of the nervous system
0.993 0.007 0.000
M20 Acquired deformities of fingers and toes
0.993 0.007 0.000
M05-M14 Inflammatory polyarthropathies
0.988 0.012 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.987 0.013 0.000
M48 Other spondylopathies
0.982 0.018 0.000
M06 Other rheumatoid arthritis
0.980 0.020 0.000
M47 Spondylosis
0.979 0.021 0.000
N93.9 Abnormal uterine and vaginal bleeding, unspecified
0.978 0.022 0.000
M20.4 Other hammer toe(s) (acquired)
0.974 0.026 0.000
M06.9 Rheumatoid arthritis, unspecified
0.973 0.027 0.000
M48.0 Spinal stenosis
0.971 0.029 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.970 0.030 0.000
I50 Heart failure
0.969 0.031 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.969 0.031 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.968 0.032 0.000
N17-N19 Renal failure
0.968 0.032 0.000
N85 Other noninflammatory disorders of uterus, except cervix
0.965 0.035 0.000
Chapter VIII Diseases of the ear and mastoid process
0.964 0.036 0.000
M47.8 Other spondylosis
0.962 0.038 0.000
M23 Internal derangement of knee
0.959 0.041 0.000
M48.06 Spinal stenosis (Lumbar region)
0.956 0.044 0.000
M25 Other joint disorders, not elsewhere classified
0.956 0.044 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.942 0.058 0.000
I05-I09 Chronic rheumatic heart diseases
0.939 0.061 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.938 0.062 0.000
R26 Abnormalities of gait and mobility
0.938 0.062 0.000
M20.1 Hallux valgus (acquired)
0.932 0.068 0.000
N18 Chronic renal failure
0.931 0.069 0.000
I44 Atrioventricular and left bundle-branch block
0.928 0.072 0.000
R07 Pain in throat and chest
0.925 0.075 0.000
Q60-Q64 Congenital malformations of the urinary system
0.919 0.081 0.000
M70-M79 Other soft tissue disorders
0.918 0.082 0.000
M40-M43 Deforming dorsopathies
0.916 0.084 0.000
I44.7 Left bundle-branch block, unspecified
0.912 0.088 0.000
N94 Pain and other conditions associated with female genital organs and menstrual cycle
0.906 0.094 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.904 0.096 0.000
H65-H75 Diseases of middle ear and mastoid
0.896 0.104 0.000
M47.87 Other spondylosis (Lumbosacral region)
0.896 0.104 0.000
M23.3 Other meniscus derangements
0.896 0.104 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.894 0.106 0.000
Chapter I Certain infectious and parasitic diseases
0.893 0.107 0.000
R07.3 Other chest pain
0.893 0.107 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.890 0.110 0.000
R26.3 Immobility
0.889 0.111 0.000
N10-N16 Renal tubulo-interstitial diseases
0.889 0.111 0.000
I51 Complications and ill-defined descriptions of heart disease
0.889 0.111 0.000
I50.1 Left ventricular failure
0.886 0.114 0.000
G30-G32 Other degenerative diseases of the nervous system
0.886 0.114 0.000
M47.82 Other spondylosis (Cervical region)
0.884 0.116 0.000
M20.5 Other deformities of toe(s) (acquired)
0.881 0.119 0.000
I46 Cardiac arrest
0.880 0.120 0.000
H90-H95 Other disorders of ear
0.879 0.121 0.000
I50.9 Heart failure, unspecified
0.870 0.130 0.000
I08 Multiple valve diseases
0.869 0.131 0.000
N18.9 Chronic renal failure, unspecified
0.869 0.131 0.000
N94.8 Other specified conditions associated with female genital organs and menstrual cycle
0.868 0.132 0.000
R41.0 Disorientation, unspecified
0.863 0.137 0.000
M65-M68 Disorders of synovium and tendon
0.863 0.137 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.860 0.140 0.000
M77 Other enthesopathies
0.856 0.144 0.000
M86-M90 Other osteopathies
0.855 0.145 0.000
R42 Dizziness and giddiness
0.854 0.146 0.000
R47-R49 Symptoms and signs involving speech and voice
0.853 0.147 0.000
N85.2 Hypertrophy of uterus
0.851 0.149 0.000
M75 Shoulder lesions
0.848 0.152 0.000
Q61 Cystic kidney disease
0.842 0.158 0.000
N85.8 Other specified noninflammatory disorders of uterus
0.839 0.161 0.000
M25.5 Pain in joint
0.838 0.162 0.000
G40-G47 Episodic and paroxysmal disorders
0.838 0.162 0.000
I47 Paroxysmal tachycardia
0.837 0.163 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.835 0.164 0.000
M47.2 Other spondylosis with radiculopathy
0.835 0.165 0.000
N00-N08 Glomerular diseases
0.834 0.166 0.000
R06 Abnormalities of breathing
0.834 0.166 0.000
N19 Unspecified renal failure
0.832 0.168 0.000
M25.4 Effusion of joint
0.831 0.169 0.000
M43 Other deforming dorsopathies
0.831 0.169 0.000
M23.8 Other internal derangements of knee
0.831 0.169 0.000
R07.2 Precordial pain
0.829 0.171 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.828 0.172 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.827 0.173 0.000
M24 Other specific joint derangements
0.824 0.176 0.000
I10-I15 Hypertensive diseases
0.822 0.178 0.000
B35-B49 Mycoses
0.822 0.178 0.000
R27 Other lack of coordination
0.820 0.180 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.819 0.181 0.000
N85.1 Endometrial adenomatous hyperplasia
0.819 0.181 0.000
M47.80 Other spondylosis (Multiple sites in spine)
0.819 0.181 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.818 0.182 0.000
M07 Psoriatic and enteropathic arthropathies
0.816 0.184 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.816 0.184 0.000
M75.0 Adhesive capsulitis of shoulder
0.816 0.184 0.000
I60-I69 Cerebrovascular diseases
0.815 0.185 0.000
M48.09 Spinal stenosis (Site unspecified)
0.813 0.187 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.812 0.188 0.000
I46.9 Cardiac arrest, unspecified
0.810 0.190 0.000
I50.0 Congestive heart failure
0.805 0.195 0.000
Chapter XX External causes of morbidity and mortality
0.805 0.195 0.000
R41.1 Anterograde amnesia
0.805 0.195 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.802 0.198 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.800 0.200 0.000
R26.8 Other and unspecified abnormalities of gait and mobility
0.799 0.201 0.000
Q63 Other congenital malformations of kidney
0.798 0.202 0.000
N89 Other noninflammatory disorders of vagina
0.797 0.203 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.796 0.204 0.000
M23.1 Discoid meniscus (congenital)
0.796 0.204 0.000
N84 Polyp of female genital tract
0.793 0.207 0.000
G81 Hemiplegia
0.792 0.208 0.000
R06.0 Dyspnoea
0.792 0.208 0.000
R49 Voice disturbances
0.792 0.208 0.000
I08.0 Disorders of both mitral and aortic valves
0.791 0.209 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.791 0.209 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.790 0.210 0.000
M23.5 Chronic instability of knee
0.790 0.210 0.000
H74 Other disorders of middle ear and mastoid
0.789 0.211 0.000
N85.9 Noninflammatory disorder of uterus, unspecified
0.789 0.211 0.000
N12 Tubulo-interstitial nephritis, not specified as acute or chronic
0.787 0.213 0.000
H93 Other disorders of ear, not elsewhere classified
0.784 0.215 0.000
R41.2 Retrograde amnesia
0.784 0.216 0.000
I51.9 Heart disease, unspecified
0.784 0.216 0.000
M77.4 Metatarsalgia
0.782 0.218 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.780 0.220 0.000
N70-N77 Inflammatory diseases of female pelvic organs
0.779 0.221 0.000
H90 Conductive and sensorineural hearing loss
0.777 0.223 0.000
M23.30 Other meniscus derangements (Multiple sites)
0.776 0.224 0.000
G70-G73 Diseases of myoneural junction and muscle
0.776 0.224 0.000
M06.3 Rheumatoid nodule
0.775 0.225 0.000
T66-T78 Other and unspecified effects of external causes
0.774 0.226 0.000
N18.0 End-stage renal disease
0.772 0.228 0.000
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)
0.771 0.229 0.000
B37 Candidiasis
0.771 0.229 0.000
N25-N29 Other disorders of kidney and ureter
0.771 0.229 0.000
Chapter II Neoplasms
0.771 0.229 0.000
M89 Other disorders of bone
0.771 0.229 0.000
M48.02 Spinal stenosis (Cervical region)
0.770 0.230 0.000
M43.1 Spondylolisthesis
0.770 0.230 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.769 0.231 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.768 0.232 0.000
S80-S89 Injuries to the knee and lower leg
0.767 0.233 0.000
I47.2 Ventricular tachycardia
0.767 0.233 0.000
M25.9 Joint disorder, unspecified
0.767 0.233 0.000
I69 Sequelae of cerebrovascular disease
0.766 0.234 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.765 0.235 0.000
G40 Epilepsy
0.764 0.236 0.000
M22 Disorders of patella
0.763 0.237 0.000
G90-G99 Other disorders of the nervous system
0.763 0.237 0.000
M25.50 Pain in joint (Multiple sites)
0.762 0.238 0.000
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.761 0.239 0.000
G35 Multiple sclerosis
0.760 0.240 0.000
I07 Rheumatic tricuspid valve diseases
0.759 0.241 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.758 0.242 0.000
G31.9 Degenerative disease of nervous system, unspecified
0.757 0.243 0.000
B37.8 Candidiasis of other sites
0.756 0.244 0.000
M10 Gout
0.756 0.244 0.000
M91-M94 Chondropathies
0.752 0.248 0.000
I30 Acute pericarditis
0.752 0.248 0.000
I45 Other conduction disorders
0.751 0.249 0.000
N85.0 Endometrial glandular hyperplasia
0.749 0.251 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.749 0.251 0.000
G37 Other demyelinating diseases of central nervous system
0.747 0.253 0.000
I51.0 Cardiac septal defect, acquired
0.745 0.255 0.000
N92 Excessive, frequent and irregular menstruation
0.745 0.255 0.000
M46 Other inflammatory spondylopathies
0.743 0.257 0.000
N18.8 Other chronic renal failure
0.743 0.257 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.742 0.258 0.000
N84.1 Polyp of cervix uteri
0.742 0.258 0.000
M60-M63 Disorders of muscles
0.739 0.260 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.739 0.260 0.000
Q61.3 Polycystic kidney, unspecified
0.739 0.261 0.000
M25.3 Other instability of joint
0.739 0.261 0.000
R07.0 Pain in throat
0.739 0.261 0.000
M65 Synovitis and tenosynovitis
0.738 0.262 0.000
M43.16 Spondylolisthesis (Lumbar region)
0.738 0.262 0.000
Chapter VII Diseases of the eye and adnexa
0.738 0.262 0.000
R49.0 Dysphonia
0.737 0.263 0.000
H71 Cholesteatoma of middle ear
0.737 0.263 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.736 0.264 0.000
I38 Endocarditis, valve unspecified
0.735 0.265 0.000
M41 Scoliosis
0.733 0.267 0.000
H65 Nonsuppurative otitis media
0.732 0.268 0.000
M48.00 Spinal stenosis (Multiple sites in spine)
0.732 0.268 0.000
R05 Cough
0.731 0.269 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.731 0.269 0.000
I34 Nonrheumatic mitral valve disorders
0.730 0.270 0.000
M75.2 Bicipital tendinitis
0.730 0.270 0.000
M77.47 Metatarsalgia-Ankle/Foot
0.729 0.271 0.000
N02 Recurrent and persistent haematuria
0.728 0.272 0.000
N18.5 Chronic kidney disease, stage 5
0.727 0.272 0.000
S10-S19 Injuries to the neck
0.726 0.273 0.000
N94.4 Primary dysmenorrhoea
0.726 0.274 0.000
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.724 0.276 0.000
S00-S09 Injuries to the head
0.724 0.276 0.000
I10 Essential (primary) hypertension
0.723 0.277 0.000
B95-B98 Bacterial, viral and other infectious agents
0.722 0.278 0.000
M00-M03 Infectious arthropathies
0.721 0.279 0.000
H66 Suppurative and unspecified otitis media
0.720 0.280 0.000
G81.9 Hemiplegia, unspecified
0.719 0.281 0.000
N82 Fistulae involving female genital tract
0.719 0.281 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.717 0.283 0.000
M33 Dermatopolymyositis
0.717 0.283 0.000
M32 Systemic lupus erythematosus
0.717 0.283 0.000
M30 Polyarteritis nodosa and related conditions
0.717 0.283 0.000
H93.1 Tinnitus
0.717 0.283 0.000
M49 Spondylopathies in diseases classified elsewhere
0.716 0.284 0.000
N98 Complications associated with artificial fertilisation
0.715 0.285 0.000
N91 Absent, scanty and rare menstruation
0.715 0.285 0.000
N96 Habitual aborter
0.715 0.285 0.000
I00-I02 Acute rheumatic fever
0.715 0.285 0.000
I60 Subarachnoid haemorrhage
0.715 0.285 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.714 0.285 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.713 0.286 0.000
I52 Other heart disorders in diseases classified elsewhere
0.713 0.287 0.000
I48 Atrial fibrillation and flutter
0.713 0.287 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.713 0.287 0.000
I41 Myocarditis in diseases classified elsewhere
0.713 0.287 0.000
I40 Acute myocarditis
0.713 0.287 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.713 0.287 0.000
I37 Pulmonary valve disorders
0.713 0.287 0.000
I32 Pericarditis in diseases classified elsewhere
0.713 0.287 0.000
T78 Adverse effects, not elsewhere classified
0.713 0.287 0.000
H80-H83 Diseases of inner ear
0.713 0.287 0.000
Q63.0 Accessory kidney
0.712 0.288 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.711 0.289 0.000
R26.0 Ataxic gait
0.710 0.290 0.000
M14 Arthropathies in other diseases classified elsewhere
0.709 0.291 0.000
M12 Other specific arthropathies
0.709 0.291 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.709 0.291 0.000
M08 Juvenile arthritis
0.709 0.291 0.000
Q61.0 Congenital single renal cyst
0.708 0.292 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.708 0.292 0.000
H30-H36 Disorders of choroid and retina
0.708 0.292 0.000
M47.27 Other spondylosis with radiculopathy (Lumbosacral region)
0.706 0.294 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.706 0.294 0.000
G83 Other paralytic syndromes
0.706 0.294 0.000
R41.3 Other amnesia
0.705 0.295 0.000
M47.86 Other spondylosis (Lumbar region)
0.705 0.295 0.000
M48.9 Spondylopathy, unspecified
0.704 0.296 0.000
M48.8 Other specified spondylopathies
0.704 0.296 0.000
M48.4 Fatigue fracture of vertebra
0.704 0.296 0.000
M48.3 Traumatic spondylopathy
0.704 0.296 0.000
M48.2 Kissing spine
0.704 0.296 0.000
M48.1 Ankylosing hyperostosis [Forestier]
0.704 0.296 0.000
N18.3 Chronic kidney disease, stage 3
0.704 0.296 0.000
M34 Systemic sclerosis
0.703 0.297 0.000
M06.8 Other specified rheumatoid arthritis
0.703 0.297 0.000
M06.4 Inflammatory polyarthropathy
0.703 0.297 0.000
M06.2 Rheumatoid bursitis
0.703 0.297 0.000
M06.1 Adult-onset Still's disease
0.703 0.297 0.000
N97 Female infertility
0.702 0.298 0.000
N75 Diseases of Bartholin's gland
0.702 0.298 0.000
G58 Other mononeuropathies
0.702 0.298 0.000
M47.0 Anterior spinal and vertebral artery compression syndromes
0.702 0.298 0.000
M50-M54 Other dorsopathies
0.702 0.298 0.000
I05 Rheumatic mitral valve diseases
0.701 0.299 0.000
H69 Other disorders of Eustachian tube
0.701 0.299 0.000
M48.5 Collapsed vertebra, not elsewhere classified
0.698 0.301 0.000
N94.6 Dysmenorrhoea, unspecified
0.698 0.302 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.698 0.302 0.000
N99-N99 Other disorders of the genitourinary system
0.698 0.302 0.000
E10-E14 Diabetes mellitus
0.698 0.302 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.697 0.303 0.000
I36 Nonrheumatic tricuspid valve disorders
0.697 0.303 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.696 0.304 0.000
M48.08 Spinal stenosis (Sacral and sacrococcygeal region)
0.696 0.304 0.000
M48.05 Spinal stenosis (Thoracolumbar region)
0.696 0.304 0.000
M48.04 Spinal stenosis (Thoracic region)
0.696 0.304 0.000
M48.03 Spinal stenosis (Cervicothoracic region)
0.696 0.304 0.000
M48.01 Spinal stenosis (Occipito-atlanto-axial region)
0.696 0.304 0.000
M25.46 Effusion of joint (Lower leg)
0.696 0.304 0.000
M25.0 Haemarthrosis
0.696 0.304 0.000
I69.3 Sequelae of cerebral infarction
0.696 0.304 0.000
R46 Symptoms and signs involving appearance and behaviour
0.695 0.305 0.000
R43 Disturbances of smell and taste
0.695 0.305 0.000
R27.0 Ataxia, unspecified
0.695 0.305 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.694 0.306 0.000
Q80-Q89 Other congenital malformations
0.694 0.306 0.000
Q35-Q37 Cleft lip and cleft palate
0.694 0.306 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.694 0.306 0.000
M07.3 Other psoriatic arthropathies
0.693 0.307 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.693 0.307 0.000
S82 Fracture of lower leg, including ankle
0.693 0.307 0.000
N85.7 Haematometra
0.692 0.308 0.000
N85.6 Intra-uterine synechiae
0.692 0.308 0.000
N85.5 Inversion of uterus
0.692 0.308 0.000
N85.3 Subinvolution of uterus
0.692 0.308 0.000
E50-E64 Other nutritional deficiencies
0.692 0.308 0.000
G45 Transient cerebral ischaemic attacks and related syndromes
0.691 0.309 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.691 0.309 0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.691 0.309 0.000
M47.88 Other spondylosis (Sacral and sacrococcygeal region)
0.690 0.310 0.000
M47.85 Other spondylosis (Thoracolumbar region)
0.690 0.310 0.000
M47.84 Other spondylosis (Thoracic region)
0.690 0.310 0.000
M47.83 Other spondylosis (Cervicothoracic region)
0.690 0.310 0.000
M47.81 Other spondylosis (Occipito-atlanto-axial region)
0.690 0.310 0.000
M21 Other acquired deformities of limbs
0.690 0.310 0.000
M75.5 Bursitis of shoulder
0.689 0.311 0.000
D41 Neoplasm of uncertain or unknown behaviour of urinary organs
0.688 0.312 0.000
M23.9 Internal derangement of knee, unspecified
0.688 0.312 0.000
M23.0 Cystic meniscus
0.688 0.312 0.000
E20-E35 Disorders of other endocrine glands
0.688 0.312 0.000
Chapter XXII Codes for special purposes
0.687 0.313 0.000
H35 Other retinal disorders
0.686 0.314 0.000
M25.2 Flail joint
0.685 0.315 0.000
M25.1 Fistula of joint
0.685 0.315 0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.685 0.315 0.000
A00-A09 Intestinal infectious diseases
0.685 0.315 0.000
G31.8 Other specified degenerative diseases of nervous system
0.684 0.316 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.684 0.316 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.683 0.317 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.681 0.319 0.000
M23.86 Other internal derangements of knee (Other and unspecified lateral meniscus)
0.679 0.321 0.000
M23.16 Discoid meniscus (congenital) (Other and unspecified lateral meniscus)
0.679 0.321 0.000
M71 Other bursopathies
0.677 0.323 0.000
M25.47 Effusion of joint (Ankle and foot)
0.677 0.323 0.000
Q00-Q07 Congenital malformations of the nervous system
0.676 0.324 0.000
M11 Other crystal arthropathies
0.674 0.326 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.674 0.326 0.000
R04 Haemorrhage from respiratory passages
0.674 0.326 0.000
R45 Symptoms and signs involving emotional state
0.674 0.326 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.674 0.326 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.674 0.326 0.000
C64-C68 Malignant neoplasms of urinary tract
0.673 0.327 0.000
I09 Other rheumatic heart diseases
0.673 0.327 0.000
I06 Rheumatic aortic valve diseases
0.673 0.327 0.000
R26.2 Difficulty in walking, not elsewhere classified
0.673 0.327 0.000
R26.1 Paralytic gait
0.673 0.327 0.000
M77.1 Lateral epicondylitis
0.672 0.327 0.000
M47.1 Other spondylosis with myelopathy
0.671 0.328 0.000
G40.9 Epilepsy, unspecified
0.671 0.329 0.000
M06.0 Seronegative rheumatoid arthritis
0.670 0.330 0.000
M23.32 Other meniscus derangements (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.669 0.331 0.000
M23.51 Chronic instability of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.668 0.332 0.000
N18.1 Chronic kidney disease, stage 1
0.667 0.333 0.000
M25.8 Other specified joint disorders
0.667 0.333 0.000
M76 Enthesopathies of lower limb, excluding foot
0.667 0.333 0.000
N13 Obstructive and reflux uropathy
0.667 0.333 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.666 0.333 0.000
M05 Seropositive rheumatoid arthritis
0.666 0.334 0.000
M65.3 Trigger finger
0.666 0.334 0.000
I44.6 Other and unspecified fascicular block
0.665 0.335 0.000
I44.5 Left posterior fascicular block
0.665 0.335 0.000
I44.4 Left anterior fascicular block
0.665 0.335 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.665 0.335 0.000
M77.9 Enthesopathy, unspecified
0.665 0.335 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.665 0.335 0.000
H74.4 Polyp of middle ear
0.665 0.335 0.000
M89.9 Disorder of bone, unspecified
0.664 0.336 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.662 0.338 0.000
N02.9 Unspecified
0.661 0.339 0.000
M20.2 Hallux rigidus
0.661 0.339 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.660 0.339 0.000
I08.1 Disorders of both mitral and tricuspid valves
0.660 0.340 0.000
R81 Glycosuria
0.660 0.340 0.000
Q64 Other congenital malformations of urinary system
0.659 0.341 0.000
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter
0.659 0.341 0.000
Q60 Renal agenesis and other reduction defects of kidney
0.659 0.341 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.658 0.341 0.000
M24.1 Other articular cartilage disorders
0.657 0.343 0.000
M42 Spinal osteochondrosis
0.657 0.343 0.000
M40 Kyphosis and lordosis
0.657 0.343 0.000
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
0.657 0.343 0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.656 0.343 0.000
M75.9 Shoulder lesion, unspecified
0.656 0.344 0.000
G82 Paraplegia and tetraplegia
0.655 0.344 0.000
G51 Facial nerve disorders
0.655 0.345 0.000
M25.56 Pain in joint (Lower leg)
0.655 0.345 0.000
N10 Acute tubulo-interstitial nephritis
0.654 0.346 0.000
N75.1 Abscess of Bartholin's gland
0.654 0.346 0.000
N11 Chronic tubulo-interstitial nephritis
0.653 0.347 0.000
S06 Intracranial injury
0.650 0.350 0.000
B99-B99 Other infectious diseases
0.650 0.350 0.000
N94.5 Secondary dysmenorrhoea
0.650 0.350 0.000
N94.3 Premenstrual tension syndrome
0.650 0.350 0.000
N94.2 Vaginismus
0.650 0.350 0.000
N94.0 Mittelschmerz
0.650 0.350 0.000
D45 Polycythaemia vera
0.649 0.351 0.000
H90.2 Conductive hearing loss, unspecified
0.649 0.351 0.000
I44.3 Other and unspecified atrioventricular block
0.648 0.352 0.000
M50 Cervical disk disorders
0.648 0.352 0.000
M89.8 Other specified disorders of bone
0.647 0.353 0.000
M66 Spontaneous rupture of synovium and tendon
0.646 0.354 0.000
G40.8 Other epilepsy
0.646 0.354 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.646 0.354 0.000
T78.1 Other adverse food reactions, not elsewhere classified
0.646 0.354 0.000
M67 Other disorders of synovium and tendon
0.645 0.355 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.644 0.356 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.644 0.356 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.644 0.356 0.000
I51.7 Cardiomegaly
0.644 0.356 0.000
B15-B19 Viral hepatitis
0.644 0.356 0.000
R44.3 Hallucinations, unspecified
0.644 0.356 0.000
H90.1 Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
0.643 0.356 0.000
M80-M85 Disorders of bone density and structure
0.643 0.357 0.000
E10 Insulin-dependent diabetes mellitus
0.643 0.357 0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.643 0.357 0.000
H70 Mastoiditis and related conditions
0.643 0.357 0.000
H68 Eustachian salpingitis and obstruction
0.643 0.357 0.000
H67 Otitis media in diseases classified elsewhere
0.643 0.357 0.000
R44.8 Other and unspecified symptoms and signs involving general sensations and perceptions
0.642 0.357 0.000
M23.37 Other meniscus derangements-Capsular lig
0.642 0.358 0.000
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)
0.642 0.358 0.000
M23.31 Other meniscus derangements (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.642 0.358 0.000
D41.4 Bladder
0.642 0.358 0.000
G80 Infantile cerebral palsy
0.641 0.359 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.640 0.359 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.640 0.359 0.000
B65-B83 Helminthiases
0.640 0.359 0.000
B50-B64 Protozoal diseases
0.640 0.359 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.640 0.359 0.000
A75-A79 Rickettsioses
0.640 0.359 0.000
A70-A74 Other diseases caused by chlamydiae
0.640 0.359 0.000
A65-A69 Other spirochaetal diseases
0.640 0.359 0.000
A20-A28 Certain zoonotic bacterial diseases
0.640 0.359 0.000
A15-A19 Tuberculosis
0.640 0.359 0.000
N08 Glomerular disorders in diseases classified elsewhere
0.639 0.361 0.000
N89.9 Noninflammatory disorder of vagina, unspecified
0.639 0.361 0.000
I69.0 Sequelae of subarachnoid haemorrhage
0.639 0.361 0.000
G36 Other acute disseminated demyelination
0.638 0.362 0.000
M24.2 Disorder of ligament
0.637 0.362 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.637 0.362 0.000
N16 Renal tubulo-interstitial disorders in diseases classified elsewhere
0.637 0.362 0.000
N15 Other renal tubulo-interstitial diseases
0.637 0.362 0.000
N14 Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
0.637 0.362 0.000
H35.0 Background retinopathy and retinal vascular changes
0.637 0.363 0.000
I51.6 Cardiovascular disease, unspecified
0.637 0.363 0.000
I51.5 Myocardial degeneration
0.637 0.363 0.000
I51.4 Myocarditis, unspecified
0.637 0.363 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.637 0.363 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.637 0.363 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.637 0.363 0.000
M47.22 Other spondylosis with radiculopathy (Cervical region)
0.636 0.364 0.000
N89.5 Stricture and atresia of vagina
0.635 0.364 0.000
Y84.2 Radiological procedure and radiotherapy
0.636 0.364 0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.635 0.365 0.000
H34 Retinal vascular occlusions
0.635 0.365 0.000
T90 Sequelae of injuries of head
0.635 0.365 0.000
I31 Other diseases of pericardium
0.634 0.366 0.000
R06.4 Hyperventilation
0.634 0.366 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.634 0.366 0.000
S80 Superficial injury of lower leg
0.633 0.367 0.000
N72 Inflammatory disease of cervix uteri
0.633 0.367 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.633 0.367 0.000
R01 Cardiac murmurs and other cardiac sounds
0.633 0.367 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.632 0.367 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.632 0.368 0.000
R44.1 Visual hallucinations
0.632 0.368 0.000
I46.1 Sudden cardiac death, so described
0.631 0.369 0.000
N17 Acute renal failure
0.631 0.369 0.000
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified
0.630 0.370 0.000
H94 Other disorders of ear in diseases classified elsewhere
0.630 0.370 0.000
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness
0.630 0.370 0.000
I07.1 Tricuspid insufficiency
0.630 0.370 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.630 0.370 0.000
C60-C63 Malignant neoplasms of male genital organs
0.629 0.371 0.000
R25 Abnormal involuntary movements
0.628 0.372 0.000
S40-S49 Injuries to the shoulder and upper arm
0.627 0.372 0.000
M06.34 Rheumatoid nodule (Hand)
0.628 0.372 0.000
G45.9 Transient cerebral ischaemic attack, unspecified
0.627 0.373 0.000
M23.4 Loose body in knee
0.626 0.374 0.000
I44.2 Atrioventricular block, complete
0.626 0.374 0.000
I45.1 Other and unspecified right bundle-branch block
0.625 0.375 0.000
I42 Cardiomyopathy
0.624 0.376 0.000
G03 Meningitis due to other and unspecified causes
0.624 0.376 0.000
M47.89 Other spondylosis (Site unspecified)
0.623 0.376 0.000
I08.9 Multiple valve disease, unspecified
0.623 0.377 0.000
I08.8 Other multiple valve diseases
0.623 0.377 0.000
I08.2 Disorders of both aortic and tricuspid valves
0.623 0.377 0.000
I11 Hypertensive heart disease
0.623 0.377 0.000
Q50-Q56 Congenital malformations of genital organs
0.622 0.378 0.000
H74.3 Other acquired abnormalities of ear ossicles
0.622 0.378 0.000
R27.8 Other and unspecified lack of coordination
0.622 0.378 0.000
I35 Nonrheumatic aortic valve disorders
0.621 0.379 0.000
M25.97 Joint disorder, unspecified (Ankle and foot)
0.620 0.380 0.000
M22.8 Other disorders of patella
0.619 0.381 0.000
W50-W64 Exposure to animate mechanical forces
0.619 0.381 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.618 0.381 0.000
N92.3 Ovulation bleeding
0.618 0.382 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.618 0.382 0.000
Q61.2 Polycystic kidney, adult type
0.617 0.383 0.000
T33-T35 Frostbite
0.617 0.383 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.617 0.383 0.000
T00-T07 Injuries involving multiple body regions
0.617 0.383 0.000
N18.4 Chronic kidney disease, stage 4
0.616 0.383 0.000
A80-A89 Viral infections of the central nervous system
0.616 0.384 0.000
Q65 Congenital deformities of hip
0.615 0.384 0.000
N71 Inflammatory disease of uterus, except cervix
0.615 0.385 0.000
M77.8 Other enthesopathies, not elsewhere classified
0.614 0.386 0.000
M77.5 Other enthesopathy of foot
0.614 0.386 0.000
M77.3 Calcaneal spur
0.614 0.386 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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