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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs113040104
log Bayes Factor = 11.1608
Chromosome 21   position 24,412,633  (GRCh37) Explore rs113040104 on Ensembl!
Variant rs113040104 is part of Cluster X0227

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
I60-I69 Cerebrovascular diseases
0.998 0.002 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.996 0.004 0.000
Chapter I Certain infectious and parasitic diseases
0.994 0.006 0.000
Chapter V Mental and behavioural disorders
0.992 0.008 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.991 0.009 0.000
Chapter VI Diseases of the nervous system
0.990 0.010 0.000
B95-B98 Bacterial, viral and other infectious agents
0.990 0.010 0.000
M70-M79 Other soft tissue disorders
0.988 0.012 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.987 0.013 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.984 0.016 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.973 0.027 0.000
O60-O75 Complications of labour and delivery
0.972 0.028 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.972 0.028 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.963 0.037 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.961 0.039 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.959 0.041 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.956 0.044 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.955 0.045 0.000
M75 Shoulder lesions
0.955 0.045 0.000
O70 Perineal laceration during delivery
0.951 0.049 0.000
Chapter II Neoplasms
0.947 0.053 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.946 0.054 0.000
S60-S69 Injuries to the wrist and hand
0.945 0.055 0.000
I60 Subarachnoid haemorrhage
0.945 0.055 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.945 0.055 0.000
I71 Aortic aneurysm and dissection
0.940 0.060 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.938 0.062 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.937 0.063 0.000
I05-I09 Chronic rheumatic heart diseases
0.933 0.067 0.000
E20-E35 Disorders of other endocrine glands
0.932 0.068 0.000
R50-R69 General symptoms and signs
0.932 0.068 0.000
I73 Other peripheral vascular diseases
0.930 0.070 0.000
I95 Hypotension
0.930 0.070 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.929 0.071 0.000
G90-G99 Other disorders of the nervous system
0.921 0.079 0.000
F03 Unspecified dementia
0.920 0.080 0.000
I95.1 Orthostatic hypotension
0.920 0.080 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.915 0.085 0.000
R26 Abnormalities of gait and mobility
0.912 0.088 0.000
R56 Convulsions, not elsewhere classified
0.912 0.088 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.910 0.090 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.909 0.091 0.000
F10 Mental and behavioural disorders due to use of alcohol
0.909 0.091 0.000
R50 Fever of unknown origin
0.904 0.096 0.000
B96.2 Escherichia coli [E. coli] as the cause of diseases classified to other chapters
0.901 0.099 0.000
M79.8 Other specified soft tissue disorders
0.901 0.099 0.000
R41.0 Disorientation, unspecified
0.898 0.102 0.000
R56.8 Other and unspecified convulsions
0.898 0.102 0.000
I30-I52 Other forms of heart disease
0.897 0.103 0.000
O70.1 Second degree perineal laceration during delivery
0.896 0.104 0.000
G40-G47 Episodic and paroxysmal disorders
0.894 0.106 0.000
M79.6 Pain in limb
0.893 0.107 0.000
F10.2 Dependence syndrome
0.893 0.107 0.000
M80-M85 Disorders of bone density and structure
0.892 0.108 0.000
R50.9 Fever, unspecified
0.891 0.109 0.000
S67 Crushing injury of wrist and hand
0.887 0.113 0.000
R26.8 Other and unspecified abnormalities of gait and mobility
0.881 0.119 0.000
O70.0 First degree perineal laceration during delivery
0.881 0.119 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.879 0.121 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.879 0.121 0.000
B96.8 Other specified bacterial agents as the cause of diseases classified to other chapters
0.878 0.122 0.000
R41.3 Other amnesia
0.874 0.126 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.872 0.128 0.000
I60.9 Subarachnoid haemorrhage, unspecified
0.865 0.135 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.865 0.135 0.000
I77 Other disorders of arteries and arterioles
0.861 0.139 0.000
E27 Other disorders of adrenal gland
0.860 0.140 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.857 0.143 0.000
I73.9 Peripheral vascular disease, unspecified
0.855 0.145 0.000
M75.1 Rotator cuff syndrome
0.855 0.145 0.000
T66-T78 Other and unspecified effects of external causes
0.853 0.147 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.849 0.151 0.000
C79 Secondary malignant neoplasm of other sites
0.848 0.152 0.000
O20 Haemorrhage in early pregnancy
0.847 0.153 0.000
S67.0 Crushing injury of thumb and other finger(s)
0.845 0.155 0.000
R55 Syncope and collapse
0.842 0.158 0.000
M79.1 Myalgia
0.840 0.160 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.839 0.161 0.000
S60 Superficial injury of wrist and hand
0.838 0.162 0.000
C64-C68 Malignant neoplasms of urinary tract
0.838 0.162 0.000
I44 Atrioventricular and left bundle-branch block
0.833 0.167 0.000
S20-S29 Injuries to the thorax
0.832 0.168 0.000
G93 Other disorders of brain
0.830 0.170 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.828 0.172 0.000
E23 Hypofunction and other disorders of pituitary gland
0.828 0.172 0.000
I08 Multiple valve diseases
0.827 0.173 0.000
I69 Sequelae of cerebrovascular disease
0.827 0.173 0.000
G81 Hemiplegia
0.826 0.174 0.000
F10.3 Withdrawal state
0.826 0.174 0.000
Chapter XX External causes of morbidity and mortality
0.825 0.175 0.000
G43 Migraine
0.823 0.177 0.000
O26 Maternal care for other conditions predominantly related to pregnancy
0.823 0.177 0.000
M75.9 Shoulder lesion, unspecified
0.822 0.178 0.000
M75.0 Adhesive capsulitis of shoulder
0.822 0.178 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.822 0.178 0.000
I72 Other aneurysm
0.822 0.178 0.000
O69 Labour and delivery complicated by umbilical cord complications
0.815 0.185 0.000
S62 Fracture at wrist and hand level
0.812 0.188 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.811 0.189 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.810 0.190 0.000
D00-D09 In situ neoplasms
0.809 0.191 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.808 0.192 0.000
B96.1 Klebsiella pneumoniae [K. pneumoniae] as the cause of diseases classified to other chapters
0.807 0.193 0.000
F01 Vascular dementia
0.806 0.194 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.802 0.198 0.000
E00-E07 Disorders of thyroid gland
0.801 0.199 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.801 0.199 0.000
S50-S59 Injuries to the elbow and forearm
0.800 0.200 0.000
O20.9 Haemorrhage in early pregnancy, unspecified
0.797 0.203 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.796 0.204 0.000
R80 Isolated proteinuria
0.795 0.205 0.000
M84 Disorders of continuity of bone
0.794 0.206 0.000
I35 Nonrheumatic aortic valve disorders
0.794 0.206 0.000
I63 Cerebral infarction
0.794 0.206 0.000
I65.2 Occlusion and stenosis of carotid artery
0.794 0.206 0.000
I74 Arterial embolism and thrombosis
0.793 0.207 0.000
M86-M90 Other osteopathies
0.792 0.208 0.000
I27 Other pulmonary heart diseases
0.791 0.209 0.000
M91-M94 Chondropathies
0.789 0.211 0.000
I05 Rheumatic mitral valve diseases
0.786 0.214 0.000
M79.86 Other specified soft tissue disorders (Lower leg)
0.785 0.215 0.000
I60.6 Subarachnoid haemorrhage from other intracranial arteries
0.785 0.215 0.000
M50-M54 Other dorsopathies
0.784 0.216 0.000
M79.7 Fibromyalgia
0.782 0.218 0.000
C64 Malignant neoplasm of kidney, except renal pelvis
0.779 0.221 0.000
S68 Traumatic amputation of wrist and hand
0.779 0.221 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.778 0.222 0.000
M40-M43 Deforming dorsopathies
0.776 0.224 0.000
M75.5 Bursitis of shoulder
0.776 0.224 0.000
G40 Epilepsy
0.775 0.225 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.774 0.226 0.000
O63 Long labour
0.770 0.230 0.000
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness
0.767 0.232 0.000
I73.0 Raynaud's syndrome
0.767 0.233 0.000
G43.1 Migraine with aura [classical migraine]
0.767 0.233 0.000
I44.2 Atrioventricular block, complete
0.767 0.233 0.000
G81.9 Hemiplegia, unspecified
0.766 0.234 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.765 0.235 0.000
B98 Other specified infectious agents as the cause of diseases classified to other chapters
0.764 0.235 0.000
E04 Other non-toxic goitre
0.763 0.237 0.000
B95.4 Other streptococcus as the cause of diseases classified to other chapters
0.762 0.238 0.000
E29 Testicular dysfunction
0.761 0.239 0.000
O73 Retained placenta and membranes, without haemorrhage
0.761 0.239 0.000
F41 Other anxiety disorders
0.760 0.240 0.000
R82 Other abnormal findings in urine
0.759 0.241 0.000
B96.4 Proteus (mirabilis)(morganii) as the cause of diseases classified to other chapters
0.759 0.241 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.758 0.242 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.757 0.243 0.000
C51-C58 Malignant neoplasms of female genital organs
0.757 0.243 0.000
Chapter XXII Codes for special purposes
0.757 0.243 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.757 0.243 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.756 0.244 0.000
M75.4 Impingement syndrome of shoulder
0.754 0.246 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
0.752 0.248 0.000
E27.1 Primary adrenocortical insufficiency
0.752 0.248 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.751 0.249 0.000
A80-A89 Viral infections of the central nervous system
0.749 0.251 0.000
I49 Other cardiac arrhythmias
0.748 0.252 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.748 0.252 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.747 0.253 0.000
M79.62 Pain in limb (Upper arm)
0.746 0.253 0.000
R53 Malaise and fatigue
0.746 0.254 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.744 0.256 0.000
T78 Adverse effects, not elsewhere classified
0.743 0.257 0.000
M60-M63 Disorders of muscles
0.742 0.257 0.000
O66 Other obstructed labour
0.741 0.259 0.000
T18 Foreign body in alimentary tract
0.741 0.259 0.000
M79.87 Other specified soft tissue disorders (Ankle and foot)
0.740 0.260 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.740 0.260 0.000
C80 Malignant neoplasm without specification of site
0.739 0.260 0.000
B97.7 Papillomavirus as the cause of diseases classified to other chapters
0.739 0.261 0.000
M79.65 Pain in limb (Pelvic region and thigh)
0.738 0.262 0.000
R47-R49 Symptoms and signs involving speech and voice
0.737 0.263 0.000
I33 Acute and subacute endocarditis
0.735 0.265 0.000
C79.8 Secondary malignant neoplasm of other specified sites
0.734 0.266 0.000
S27 Injury of other and unspecified intrathoracic organs
0.734 0.266 0.000
I62 Other nontraumatic intracranial haemorrhage
0.733 0.267 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.732 0.267 0.000
G95 Other diseases of spinal cord
0.731 0.268 0.000
M79.66 Pain in limb (Lower leg)
0.729 0.271 0.000
M79.89 Other specified soft tissue disorders (Site unspecified)
0.728 0.272 0.000
Q00-Q07 Congenital malformations of the nervous system
0.727 0.273 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.727 0.273 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.727 0.273 0.000
E34 Other endocrine disorders
0.726 0.274 0.000
E23.0 Hypopituitarism
0.725 0.275 0.000
O26.8 Other specified pregnancy-related conditions
0.724 0.276 0.000
I71.3 Abdominal aortic aneurysm, ruptured
0.723 0.277 0.000
S90-S99 Injuries to the ankle and foot
0.723 0.277 0.000
E22 Hyperfunction of pituitary gland
0.723 0.277 0.000
S70-S79 Injuries to the hip and thigh
0.722 0.278 0.000
B96.3 Haemophilus influenzae [H. influenzae] as the cause of diseases classified to other chapters
0.721 0.278 0.000
I07 Rheumatic tricuspid valve diseases
0.721 0.279 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.721 0.279 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.720 0.280 0.000
E04.1 Non-toxic single thyroid nodule
0.718 0.282 0.000
G91 Hydrocephalus
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.715 0.284 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.715 0.284 0.000
G93.4 Encephalopathy, unspecified
0.714 0.286 0.000
M00-M03 Infectious arthropathies
0.714 0.286 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.714 0.286 0.000
B95.7 Other staphylococcus as the cause of diseases classified to other chapters
0.714 0.286 0.000
I51 Complications and ill-defined descriptions of heart disease
0.714 0.286 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.714 0.286 0.000
B99-B99 Other infectious diseases
0.712 0.287 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.712 0.287 0.000
B65-B83 Helminthiases
0.712 0.287 0.000
B50-B64 Protozoal diseases
0.712 0.287 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.712 0.287 0.000
A75-A79 Rickettsioses
0.712 0.287 0.000
A70-A74 Other diseases caused by chlamydiae
0.712 0.287 0.000
A65-A69 Other spirochaetal diseases
0.712 0.287 0.000
A20-A28 Certain zoonotic bacterial diseases
0.712 0.287 0.000
A15-A19 Tuberculosis
0.712 0.287 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.711 0.289 0.000
F70-F79 Mental retardation
0.711 0.289 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.711 0.289 0.000
I60.1 Subarachnoid haemorrhage from middle cerebral artery
0.711 0.289 0.000
B25-B34 Other viral diseases
0.710 0.290 0.000
G90 Disorders of autonomic nervous system
0.710 0.290 0.000
Chapter VIII Diseases of the ear and mastoid process
0.710 0.290 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.710 0.290 0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters
0.710 0.290 0.000
G63.2 Diabetic polyneuropathy
0.709 0.291 0.000
G96 Other disorders of central nervous system
0.709 0.291 0.000
G80 Infantile cerebral palsy
0.709 0.291 0.000
G70-G73 Diseases of myoneural junction and muscle
0.708 0.291 0.000
M79.10 Myalgia (Multiple sites)
0.708 0.292 0.000
I98 Other disorders of circulatory system in diseases classified elsewhere
0.708 0.292 0.000
M76 Enthesopathies of lower limb, excluding foot
0.708 0.292 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.708 0.292 0.000
M50 Cervical disk disorders
0.708 0.292 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.707 0.292 0.000
M79.60 Pain in limb (Multiple sites)
0.707 0.293 0.000
M84.1 Nonunion of fracture [pseudarthrosis]
0.706 0.294 0.000
M85 Other disorders of bone density and structure
0.706 0.294 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.706 0.294 0.000
O85-O92 Complications predominantly related to the puerperium
0.705 0.295 0.000
I99 Other and unspecified disorders of circulatory system
0.705 0.295 0.000
S60.9 Superficial injury of wrist and hand, unspecified
0.704 0.296 0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.704 0.296 0.000
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum
0.703 0.297 0.000
G41 Status epilepticus
0.702 0.298 0.000
I60.2 Subarachnoid haemorrhage from anterior communicating artery
0.702 0.298 0.000
S60.8 Other superficial injuries of wrist and hand
0.702 0.298 0.000
G93.0 Cerebral cysts
0.702 0.298 0.000
I78 Diseases of capillaries
0.702 0.298 0.000
F41.0 Panic disorder [episodic paroxysmal anxiety]
0.702 0.298 0.000
A30-A49 Other bacterial diseases
0.701 0.299 0.000
O24 Diabetes mellitus in pregnancy
0.701 0.299 0.000
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
0.700 0.300 0.000
O63.9 Long labour, unspecified
0.700 0.300 0.000
I35.1 Aortic (valve) insufficiency
0.698 0.302 0.000
M79.9 Soft tissue disorder, unspecified
0.698 0.302 0.000
M79.5 Residual foreign body in soft tissue
0.698 0.302 0.000
M79.4 Hypertrophy of (infrapatellar) fat pad
0.698 0.302 0.000
M79.3 Panniculitis, unspecified
0.698 0.302 0.000
M79.2 Neuralgia and neuritis, unspecified
0.698 0.302 0.000
S10-S19 Injuries to the neck
0.697 0.303 0.000
O69.2 Labour and delivery complicated by other cord entanglement
0.697 0.303 0.000
I67 Other cerebrovascular diseases
0.697 0.303 0.000
I77.0 Arteriovenous fistula, acquired
0.697 0.303 0.000
O74 Complications of anaesthesia during labour and delivery
0.697 0.303 0.000
O71 Other obstetric trauma
0.697 0.303 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.697 0.303 0.000
O62 Abnormalities of forces of labour
0.697 0.303 0.000
O61 Failed induction of labour
0.697 0.303 0.000
O60 Preterm delivery
0.697 0.303 0.000
B96.7 Clostridium perfringens [C. perfringens] as the cause of diseases classified to other chapters
0.697 0.303 0.000
B96.6 Bacillus fragilis [B. fragilis] as the cause of diseases classified to other chapters
0.697 0.303 0.000
B96.0 Mycoplasma pneumoniae [M. pneumoniae] as the cause of diseases classified to other chapters
0.697 0.303 0.000
S52 Fracture of forearm
0.697 0.303 0.000
C79.7 Secondary malignant neoplasm of adrenal gland
0.697 0.303 0.000
G30-G32 Other degenerative diseases of the nervous system
0.696 0.304 0.000
F41.2 Mixed anxiety and depressive disorder
0.696 0.304 0.000
C78.0 Secondary malignant neoplasm of lung
0.696 0.304 0.000
R81 Glycosuria
0.695 0.305 0.000
M71 Other bursopathies
0.695 0.305 0.000
R60 Oedema, not elsewhere classified
0.695 0.305 0.000
I71.0 Dissection of aorta [any part]
0.695 0.305 0.000
R25 Abnormal involuntary movements
0.694 0.306 0.000
F01.9 Vascular dementia, unspecified
0.694 0.306 0.000
O21 Excessive vomiting in pregnancy
0.694 0.306 0.000
I70 Atherosclerosis
0.693 0.307 0.000
I61 Intracerebral haemorrhage
0.692 0.308 0.000
T68 Hypothermia
0.691 0.309 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.691 0.309 0.000
I38 Endocarditis, valve unspecified
0.691 0.309 0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction
0.690 0.310 0.000
F02 Dementia in other diseases classified elsewhere
0.690 0.310 0.000
F09 Unspecified organic or symptomatic mental disorder
0.690 0.310 0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances
0.690 0.310 0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease
0.690 0.310 0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.689 0.311 0.000
F80-F89 Disorders of psychological development
0.689 0.311 0.000
I44.3 Other and unspecified atrioventricular block
0.689 0.311 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.689 0.311 0.000
C71 Malignant neoplasm of brain
0.689 0.311 0.000
R23 Other skin changes
0.688 0.312 0.000
B15-B19 Viral hepatitis
0.687 0.313 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.686 0.314 0.000
F60-F69 Disorders of adult personality and behaviour
0.686 0.314 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.686 0.314 0.000
T33-T35 Frostbite
0.685 0.314 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.685 0.314 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.685 0.314 0.000
T00-T07 Injuries involving multiple body regions
0.685 0.314 0.000
M79.61 Pain in limb (Shoulder region)
0.685 0.315 0.000
M75.8 Other shoulder lesions
0.685 0.315 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.685 0.315 0.000
I77.1 Stricture of artery
0.684 0.316 0.000
R41.2 Retrograde amnesia
0.684 0.316 0.000
D04 Carcinoma in situ of skin
0.684 0.316 0.000
G83 Other paralytic syndromes
0.683 0.317 0.000
G62 Other polyneuropathies
0.683 0.317 0.000
T18.1 Foreign body in oesophagus
0.682 0.318 0.000
D03 Melanoma in situ
0.682 0.318 0.000
O70.9 Perineal laceration during delivery, unspecified
0.682 0.318 0.000
O70.3 Fourth degree perineal laceration during delivery
0.682 0.318 0.000
R45 Symptoms and signs involving emotional state
0.681 0.319 0.000
S62.5 Fracture of thumb
0.680 0.320 0.000
R22 Localised swelling, mass and lump of skin and subcutaneous tissue
0.680 0.320 0.000
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system
0.680 0.320 0.000
Q80-Q89 Other congenital malformations
0.679 0.321 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.679 0.321 0.000
F30-F39 Mood [affective] disorders
0.679 0.321 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.679 0.321 0.000
W20-W49 Exposure to inanimate mechanical forces
0.678 0.322 0.000
D45 Polycythaemia vera
0.678 0.322 0.000
S69 Other and unspecified injuries of wrist and hand
0.678 0.322 0.000
S65 Injury of blood vessels at wrist and hand level
0.678 0.322 0.000
I60.8 Other subarachnoid haemorrhage
0.677 0.322 0.000
I60.7 Subarachnoid haemorrhage from intracranial artery, unspecified
0.677 0.322 0.000
I60.5 Subarachnoid haemorrhage from vertebral artery
0.677 0.322 0.000
I60.4 Subarachnoid haemorrhage from basilar artery
0.677 0.322 0.000
I60.3 Subarachnoid haemorrhage from posterior communicating artery
0.677 0.322 0.000
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation
0.677 0.322 0.000
R46 Symptoms and signs involving appearance and behaviour
0.677 0.323 0.000
R43 Disturbances of smell and taste
0.677 0.323 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.677 0.323 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.677 0.323 0.000
I77.9 Disorder of arteries and arterioles, unspecified
0.676 0.324 0.000
B35-B49 Mycoses
0.676 0.324 0.000
I95.2 Hypotension due to drugs
0.676 0.324 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.675 0.325 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.675 0.325 0.000
M77 Other enthesopathies
0.674 0.326 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.674 0.326 0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.674 0.326 0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.674 0.326 0.000
I71.1 Thoracic aortic aneurysm, ruptured
0.674 0.326 0.000
F10.1 Harmful use
0.674 0.326 0.000
C34 Malignant neoplasm of bronchus and lung
0.673 0.327 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.673 0.327 0.000
O29 Complications of anaesthesia during pregnancy
0.673 0.327 0.000
O28 Abnormal findings on antenatal screening of mother
0.673 0.327 0.000
O23 Infections of genito-urinary tract in pregnancy
0.673 0.327 0.000
O22 Venous complications in pregnancy
0.673 0.327 0.000
O25 Malnutrition in pregnancy
0.673 0.327 0.000
O70.2 Third degree perineal laceration during delivery
0.672 0.328 0.000
R41.1 Anterograde amnesia
0.672 0.328 0.000
D06 Carcinoma in situ of cervix uteri
0.671 0.329 0.000
I27.0 Primary pulmonary hypertension
0.670 0.330 0.000
I09 Other rheumatic heart diseases
0.669 0.331 0.000
I06 Rheumatic aortic valve diseases
0.669 0.331 0.000
I27.2 Other secondary pulmonary hypertension
0.669 0.331 0.000
M79.18 Myalgia (Other)
0.669 0.331 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.668 0.332 0.000
E32 Diseases of thymus
0.668 0.332 0.000
E31 Polyglandular dysfunction
0.668 0.332 0.000
E30 Disorders of puberty, not elsewhere classified
0.668 0.332 0.000
E26 Hyperaldosteronism
0.668 0.332 0.000
E25 Adrenogenital disorders
0.668 0.332 0.000
E24 Cushing's syndrome
0.668 0.332 0.000
E20 Hypoparathyroidism
0.668 0.332 0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]
0.668 0.332 0.000
R62 Lack of expected normal physiological development
0.668 0.332 0.000
R64 Cachexia
0.668 0.332 0.000
R58 Haemorrhage, not elsewhere classified
0.668 0.332 0.000
I73.8 Other specified peripheral vascular diseases
0.667 0.333 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.667 0.333 0.000
I95.8 Other hypotension
0.667 0.333 0.000
I95.0 Idiopathic hypotension
0.667 0.333 0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.667 0.333 0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances
0.666 0.334 0.000
F18 Mental and behavioural disorders due to use of volatile solvents
0.666 0.334 0.000
F16 Mental and behavioural disorders due to use of hallucinogens
0.666 0.334 0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine
0.666 0.334 0.000
F14 Mental and behavioural disorders due to use of cocaine
0.666 0.334 0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics
0.666 0.334 0.000
F12 Mental and behavioural disorders due to use of cannabinoids
0.666 0.334 0.000
F11 Mental and behavioural disorders due to use of opioids
0.666 0.334 0.000
B95.2 Streptococcus, group D, as the cause of diseases classified to other chapters
0.666 0.334 0.000
B95.0 Streptococcus, group A, as the cause of diseases classified to other chapters
0.666 0.334 0.000
G40.9 Epilepsy, unspecified
0.666 0.334 0.000
M79.63 Pain in limb (Forearm)
0.665 0.335 0.000
F00 Dementia in Alzheimer's disease
0.665 0.335 0.000
E40-E46 Malnutrition
0.664 0.336 0.000
S27.0 Traumatic pneumothorax
0.663 0.337 0.000
R29.6 Tendency to fall, not elsewhere classified
0.662 0.338 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.661 0.339 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.661 0.339 0.000
G92 Toxic encephalopathy
0.661 0.339 0.000
B97.8 Other viral agents as the cause of diseases classified to other chapters
0.661 0.339 0.000
R68 Other general symptoms and signs
0.660 0.340 0.000
S68.1 Traumatic amputation of other single finger (complete)(partial)
0.660 0.340 0.000
E50-E64 Other nutritional deficiencies
0.658 0.342 0.000
O75.7 Vaginal delivery following previous Caesarean section
0.658 0.342 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.658 0.342 0.000
I44.6 Other and unspecified fascicular block
0.657 0.343 0.000
I69.3 Sequelae of cerebral infarction
0.656 0.344 0.000
E23.2 Diabetes insipidus
0.656 0.344 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.656 0.344 0.000
I45 Other conduction disorders
0.655 0.345 0.000
M72 Fibroblastic disorders
0.655 0.345 0.000
M79.69 Pain in limb (Site unspecified)
0.655 0.345 0.000
G93.2 Benign intracranial hypertension
0.655 0.345 0.000
G82 Paraplegia and tetraplegia
0.655 0.345 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.654 0.346 0.000
T79-T79 Certain early complications of trauma
0.654 0.346 0.000
S62.7 Multiple fractures of fingers
0.654 0.346 0.000
R26.3 Immobility
0.654 0.346 0.000
R26.2 Difficulty in walking, not elsewhere classified
0.654 0.346 0.000
R26.1 Paralytic gait
0.654 0.346 0.000
R26.0 Ataxic gait
0.654 0.346 0.000
R56.0 Febrile convulsions
0.654 0.346 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.654 0.346 0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs
0.654 0.346 0.000
T78.4 Allergy, unspecified
0.652 0.348 0.000
F10.9 Unspecified mental and behavioural disorder
0.652 0.348 0.000
F10.8 Other mental and behavioural disorders
0.652 0.348 0.000
F10.7 Residual and late-onset psychotic disorder
0.652 0.348 0.000
F10.6 Amnesic syndrome
0.652 0.348 0.000
F10.5 Psychotic disorder
0.652 0.348 0.000
S64 Injury of nerves at wrist and hand level
0.652 0.348 0.000
I27.9 Pulmonary heart disease, unspecified
0.651 0.349 0.000
Q50-Q56 Congenital malformations of genital organs
0.651 0.349 0.000
C79.0 Secondary malignant neoplasm of kidney and renal pelvis
0.650 0.350 0.000
H60-H62 Diseases of external ear
0.650 0.350 0.000
I72.0 Aneurysm of carotid artery
0.650 0.350 0.000
C32 Malignant neoplasm of larynx
0.650 0.350 0.000
E28 Ovarian dysfunction
0.650 0.350 0.000
F99-F99 Unspecified mental disorder
0.649 0.351 0.000
M50.2 Other cervical disk displacement
0.649 0.351 0.000
M79.80 Other specified soft tissue disorders (Multiple sites)
0.648 0.352 0.000
R50.8 Other specified fever
0.648 0.352 0.000
R50.2 Drug-induced fever
0.648 0.352 0.000
R50.1 Persistent fever
0.648 0.352 0.000
Chapter VII Diseases of the eye and adnexa
0.648 0.352 0.000
I69.0 Sequelae of subarachnoid haemorrhage
0.647 0.353 0.000
G40.1 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
0.647 0.353 0.000
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
0.646 0.354 0.000
M79.88 Other specified soft tissue disorders (Other)
0.646 0.354 0.000
M79.85 Other specified soft tissue disorders (Pelvic region and thigh)
0.646 0.354 0.000
M79.83 Other specified soft tissue disorders (Forearm)
0.646 0.354 0.000
M79.82 Other specified soft tissue disorders (Upper arm)
0.646 0.354 0.000
M79.81 Other specified soft tissue disorders (Shoulder region)
0.646 0.354 0.000
M81 Osteoporosis without pathological fracture
0.646 0.354 0.000
M79.79 Fibromyalgia (Site unspecified)
0.645 0.355 0.000
I30 Acute pericarditis
0.644 0.356 0.000
F10.4 Withdrawal state with delirium
0.644 0.356 0.000
I52 Other heart disorders in diseases classified elsewhere
0.643 0.357 0.000
I48 Atrial fibrillation and flutter
0.643 0.357 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.643 0.357 0.000
I41 Myocarditis in diseases classified elsewhere
0.643 0.357 0.000
I40 Acute myocarditis
0.643 0.357 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.643 0.357 0.000
I37 Pulmonary valve disorders
0.643 0.357 0.000
I36 Nonrheumatic tricuspid valve disorders
0.643 0.357 0.000
I32 Pericarditis in diseases classified elsewhere
0.643 0.357 0.000
I08.2 Disorders of both aortic and tricuspid valves
0.643 0.357 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.641 0.359 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.640 0.360 0.000
M79.68 Pain in limb (Other)
0.640 0.360 0.000
R27 Other lack of coordination
0.640 0.360 0.000
I72.4 Aneurysm of artery of lower extremity
0.640 0.360 0.000
M83 Adult osteomalacia
0.639 0.360 0.000
M82 Osteoporosis in diseases classified elsewhere
0.639 0.360 0.000
I08.0 Disorders of both mitral and aortic valves
0.638 0.362 0.000
E29.1 Testicular hypofunction
0.638 0.362 0.000
M84.4 Pathological fracture, not elsewhere classified
0.638 0.362 0.000
M80 Osteoporosis with pathological fracture
0.638 0.362 0.000
M45-M49 Spondylopathies
0.637 0.363 0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.636 0.364 0.000
M43 Other deforming dorsopathies
0.636 0.364 0.000
S67.8 Crushing injury of other and unspecified parts of wrist and hand
0.636 0.364 0.000
B95.3 Streptococcus pneumoniae as the cause of diseases classified to other chapters
0.635 0.365 0.000
M75.2 Bicipital tendinitis
0.634 0.365 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.634 0.366 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.632 0.368 0.000
S62.2 Fracture of first metacarpal bone
0.630 0.370 0.000
I65.9 Occlusion and stenosis of unspecified precerebral artery
0.630 0.370 0.000
I65.8 Occlusion and stenosis of other precerebral artery
0.630 0.370 0.000
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries
0.630 0.370 0.000
I65.1 Occlusion and stenosis of basilar artery
0.630 0.370 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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