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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs114249449
log Bayes Factor = 15.308
Chromosome 1   position 39,257,678  (GRCh37) Explore rs114249449 on Ensembl!
Variant rs114249449 is part of Cluster X0045

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
Chapter II Neoplasms
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
I30-I52 Other forms of heart disease
0.998 0.002 0.000
D10-D36 Benign neoplasms
0.998 0.002 0.000
Chapter XIV Diseases of the genitourinary system
0.997 0.003 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.993 0.007 0.000
C15-C26 Malignant neoplasms of digestive organs
0.991 0.009 0.000
I10-I15 Hypertensive diseases
0.989 0.011 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.988 0.012 0.000
E70-E90 Metabolic disorders
0.988 0.012 0.000
E10-E14 Diabetes mellitus
0.988 0.012 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.986 0.014 0.000
I44 Atrioventricular and left bundle-branch block
0.985 0.015 0.000
I44.7 Left bundle-branch block, unspecified
0.981 0.019 0.000
D23 Other benign neoplasms of skin
0.981 0.019 0.000
Chapter VII Diseases of the eye and adnexa
0.980 0.020 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.978 0.022 0.000
I50 Heart failure
0.976 0.024 0.000
Chapter V Mental and behavioural disorders
0.974 0.026 0.000
E11 Non-insulin-dependent diabetes mellitus
0.973 0.027 0.000
I10 Essential (primary) hypertension
0.967 0.033 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.965 0.035 0.000
N00-N08 Glomerular diseases
0.963 0.037 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.963 0.037 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.958 0.042 0.000
E87.2 Acidosis
0.951 0.049 0.000
C18 Malignant neoplasm of colon
0.950 0.050 0.000
D12 Benign neoplasm of colon, rectum, anus and anal canal
0.944 0.056 0.000
N17-N19 Renal failure
0.942 0.058 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.942 0.058 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.941 0.059 0.000
I50.1 Left ventricular failure
0.941 0.059 0.000
D23.1 Skin of eyelid, including canthus
0.939 0.061 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.932 0.068 0.000
N70-N77 Inflammatory diseases of female pelvic organs
0.929 0.071 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.928 0.072 0.000
Chapter XX External causes of morbidity and mortality
0.922 0.078 0.000
Chapter I Certain infectious and parasitic diseases
0.918 0.082 0.000
F30-F39 Mood [affective] disorders
0.916 0.084 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.912 0.088 0.000
D22 Melanocytic naevi
0.910 0.090 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.908 0.092 0.000
D12.4 Descending colon
0.907 0.093 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.906 0.094 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.896 0.104 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.895 0.105 0.000
N18 Chronic renal failure
0.893 0.107 0.000
D69 Purpura and other haemorrhagic conditions
0.892 0.108 0.000
C20 Malignant neoplasm of rectum
0.890 0.110 0.000
N60-N64 Disorders of breast
0.888 0.112 0.000
H02 Other disorders of eyelid
0.887 0.113 0.000
D23.3 Skin of other and unspecified parts of face
0.886 0.114 0.000
I12 Hypertensive renal disease
0.885 0.115 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.883 0.117 0.000
N08 Glomerular disorders in diseases classified elsewhere
0.883 0.117 0.000
N10-N16 Renal tubulo-interstitial diseases
0.879 0.121 0.000
E87.6 Hypokalaemia
0.878 0.122 0.000
D69.6 Thrombocytopenia, unspecified
0.875 0.125 0.000
I60-I69 Cerebrovascular diseases
0.875 0.125 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.873 0.127 0.000
E11.5 With peripheral circulatory complications
0.873 0.127 0.000
D22.5 Melanocytic naevi of trunk
0.872 0.128 0.000
N03 Chronic nephritic syndrome
0.870 0.130 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.868 0.132 0.000
F31 Bipolar affective disorder
0.867 0.133 0.000
I34 Nonrheumatic mitral valve disorders
0.866 0.134 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.865 0.135 0.000
E65-E68 Obesity and other hyperalimentation
0.865 0.135 0.000
D17 Benign lipomatous neoplasm
0.862 0.138 0.000
E11.3 With ophthalmic complications
0.860 0.140 0.000
M05-M14 Inflammatory polyarthropathies
0.859 0.141 0.000
H30-H36 Disorders of choroid and retina
0.856 0.144 0.000
I74 Arterial embolism and thrombosis
0.853 0.147 0.000
N20-N23 Urolithiasis
0.853 0.147 0.000
Y83.6 Removal of other organ (partial) (total)
0.850 0.150 0.000
D27 Benign neoplasm of ovary
0.850 0.150 0.000
M70-M79 Other soft tissue disorders
0.842 0.158 0.000
C25 Malignant neoplasm of pancreas
0.838 0.162 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.838 0.162 0.000
Y83.8 Other surgical procedures
0.838 0.162 0.000
N73 Other female pelvic inflammatory diseases
0.838 0.162 0.000
E11.2 With renal complications
0.837 0.163 0.000
E87.7 Fluid overload
0.835 0.165 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.831 0.169 0.000
I71 Aortic aneurysm and dissection
0.827 0.173 0.000
S50-S59 Injuries to the elbow and forearm
0.826 0.174 0.000
N08.3 Glomerular disorders in diabetes mellitus
0.825 0.174 0.000
C18.7 Sigmoid colon
0.823 0.177 0.000
Chapter XXII Codes for special purposes
0.822 0.177 0.000
C77.2 Intra-abdominal lymph nodes
0.822 0.178 0.000
Y83.1 Surgical operation with implant of artificial internal device
0.821 0.179 0.000
C15 Malignant neoplasm of oesophagus
0.820 0.180 0.000
I95 Hypotension
0.818 0.182 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.817 0.183 0.000
H02.9 Disorder of eyelid, unspecified
0.811 0.189 0.000
H02.3 Blepharochalasis
0.809 0.191 0.000
Chapter VI Diseases of the nervous system
0.809 0.191 0.000
E10 Insulin-dependent diabetes mellitus
0.808 0.192 0.000
D00-D09 In situ neoplasms
0.805 0.194 0.000
E11.6 With other specified complications
0.805 0.195 0.000
M50-M54 Other dorsopathies
0.804 0.196 0.000
N03.9 Unspecified
0.803 0.197 0.000
I67 Other cerebrovascular diseases
0.802 0.198 0.000
D12.5 Sigmoid colon
0.802 0.198 0.000
Chapter VIII Diseases of the ear and mastoid process
0.801 0.199 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.799 0.201 0.000
S20-S29 Injuries to the thorax
0.798 0.202 0.000
A00-A09 Intestinal infectious diseases
0.798 0.202 0.000
M06 Other rheumatoid arthritis
0.794 0.206 0.000
N20 Calculus of kidney and ureter
0.794 0.206 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.793 0.207 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.792 0.208 0.000
I50.0 Congestive heart failure
0.790 0.210 0.000
I34.0 Mitral (valve) insufficiency
0.790 0.210 0.000
H00 Hordeolum and chalazion
0.789 0.211 0.000
D23.4 Skin of scalp and neck
0.789 0.211 0.000
E20-E35 Disorders of other endocrine glands
0.787 0.213 0.000
C78.0 Secondary malignant neoplasm of lung
0.787 0.213 0.000
H35 Other retinal disorders
0.787 0.213 0.000
N18.9 Chronic renal failure, unspecified
0.787 0.213 0.000
I50.9 Heart failure, unspecified
0.786 0.214 0.000
I12.0 Hypertensive renal disease with renal failure
0.783 0.217 0.000
S80-S89 Injuries to the knee and lower leg
0.783 0.217 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.779 0.221 0.000
H43-H45 Disorders of vitreous body and globe
0.779 0.221 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.778 0.222 0.000
N64 Other disorders of breast
0.777 0.223 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.774 0.226 0.000
C21 Malignant neoplasm of anus and anal canal
0.773 0.227 0.000
C77.5 Intrapelvic lymph nodes
0.772 0.228 0.000
I77 Other disorders of arteries and arterioles
0.772 0.228 0.000
S90-S99 Injuries to the ankle and foot
0.771 0.229 0.000
Chapter X Diseases of the respiratory system
0.771 0.229 0.000
E11.4 With neurological complications
0.769 0.231 0.000
C18.3 Hepatic flexure
0.769 0.231 0.000
E16 Other disorders of pancreatic internal secretion
0.768 0.232 0.000
E66 Obesity
0.768 0.232 0.000
C18.9 Colon, unspecified
0.767 0.233 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.767 0.233 0.000
E40-E46 Malnutrition
0.766 0.234 0.000
N17 Acute renal failure
0.766 0.234 0.000
I60 Subarachnoid haemorrhage
0.764 0.236 0.000
D12.6 Colon, unspecified
0.762 0.238 0.000
F31.9 Bipolar affective disorder, unspecified
0.762 0.238 0.000
D34 Benign neoplasm of thyroid gland
0.761 0.239 0.000
I35 Nonrheumatic aortic valve disorders
0.759 0.241 0.000
D12.0 Caecum
0.759 0.241 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.759 0.241 0.000
N20.0 Calculus of kidney
0.759 0.241 0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants
0.758 0.242 0.000
N73.6 Female pelvic peritoneal adhesions
0.756 0.244 0.000
D10 Benign neoplasm of mouth and pharynx
0.755 0.245 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.754 0.245 0.000
H10-H13 Disorders of conjunctiva
0.752 0.248 0.000
N76 Other inflammation of vagina and vulva
0.752 0.248 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.751 0.249 0.000
M86-M90 Other osteopathies
0.750 0.249 0.000
D23.6 Skin of upper limb, including shoulder
0.750 0.250 0.000
I78 Diseases of capillaries
0.750 0.250 0.000
C18.0 Caecum
0.749 0.251 0.000
E14 Unspecified diabetes mellitus
0.748 0.252 0.000
M51 Other intervertebral disk disorders
0.746 0.253 0.000
N99-N99 Other disorders of the genitourinary system
0.745 0.254 0.000
Y83.3 Surgical operation with formation of external stoma
0.744 0.256 0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts
0.744 0.256 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.744 0.256 0.000
E88 Other metabolic disorders
0.743 0.257 0.000
C78.7 Secondary malignant neoplasm of liver
0.743 0.257 0.000
H25-H28 Disorders of lens
0.742 0.258 0.000
F03 Unspecified dementia
0.742 0.258 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.742 0.258 0.000
I99 Other and unspecified disorders of circulatory system
0.741 0.259 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.739 0.261 0.000
I38 Endocarditis, valve unspecified
0.738 0.262 0.000
N04 Nephrotic syndrome
0.738 0.262 0.000
N12 Tubulo-interstitial nephritis, not specified as acute or chronic
0.738 0.262 0.000
M45-M49 Spondylopathies
0.737 0.263 0.000
N18.2 Chronic kidney disease, stage 2
0.737 0.263 0.000
I73 Other peripheral vascular diseases
0.736 0.264 0.000
C25.9 Pancreas, unspecified
0.735 0.265 0.000
E87.5 Hyperkalaemia
0.734 0.266 0.000
C18.5 Splenic flexure
0.734 0.266 0.000
N25-N29 Other disorders of kidney and ureter
0.732 0.268 0.000
D12.7 Rectosigmoid junction
0.732 0.268 0.000
H36 Retinal disorders in diseases classified elsewhere
0.730 0.270 0.000
I72 Other aneurysm
0.730 0.270 0.000
G90-G99 Other disorders of the nervous system
0.730 0.270 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.728 0.272 0.000
I33 Acute and subacute endocarditis
0.728 0.272 0.000
D35 Benign neoplasm of other and unspecified endocrine glands
0.728 0.272 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.727 0.273 0.000
D36 Benign neoplasm of other and unspecified sites
0.726 0.274 0.000
N18.3 Chronic kidney disease, stage 3
0.726 0.274 0.000
I47 Paroxysmal tachycardia
0.726 0.274 0.000
A30-A49 Other bacterial diseases
0.725 0.275 0.000
B65-B83 Helminthiases
0.723 0.277 0.000
M06.9 Rheumatoid arthritis, unspecified
0.723 0.277 0.000
B25-B34 Other viral diseases
0.722 0.278 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.721 0.279 0.000
H01 Other inflammation of eyelid
0.721 0.279 0.000
D23.7 Skin of lower limb, including hip
0.721 0.279 0.000
F99-F99 Unspecified mental disorder
0.720 0.280 0.000
F60-F69 Disorders of adult personality and behaviour
0.718 0.282 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.717 0.283 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.717 0.283 0.000
I52 Other heart disorders in diseases classified elsewhere
0.716 0.284 0.000
I48 Atrial fibrillation and flutter
0.716 0.284 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.716 0.284 0.000
I41 Myocarditis in diseases classified elsewhere
0.716 0.284 0.000
I40 Acute myocarditis
0.716 0.284 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.716 0.284 0.000
I37 Pulmonary valve disorders
0.716 0.284 0.000
I36 Nonrheumatic tricuspid valve disorders
0.716 0.284 0.000
I32 Pericarditis in diseases classified elsewhere
0.716 0.284 0.000
I30 Acute pericarditis
0.716 0.284 0.000
D33 Benign neoplasm of brain and other parts of central nervous system
0.716 0.284 0.000
D31 Benign neoplasm of eye and adnexa
0.716 0.284 0.000
D30 Benign neoplasm of urinary organs
0.716 0.284 0.000
D29 Benign neoplasm of male genital organs
0.716 0.284 0.000
D28 Benign neoplasm of other and unspecified female genital organs
0.716 0.284 0.000
D26 Other benign neoplasms of uterus
0.716 0.284 0.000
D21 Other benign neoplasms of connective and other soft tissue
0.716 0.284 0.000
D20 Benign neoplasm of soft tissue of retroperitoneum and peritoneum
0.716 0.284 0.000
D19 Benign neoplasm of mesothelial tissue
0.716 0.284 0.000
D16 Benign neoplasm of bone and articular cartilage
0.716 0.284 0.000
D15 Benign neoplasm of other and unspecified intrathoracic organs
0.716 0.284 0.000
D14 Benign neoplasm of middle ear and respiratory system
0.716 0.284 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.714 0.285 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.714 0.285 0.000
F80-F89 Disorders of psychological development
0.714 0.286 0.000
H55-H59 Other disorders of eye and adnexa
0.714 0.286 0.000
N61 Inflammatory disorders of breast
0.713 0.287 0.000
T79-T79 Certain early complications of trauma
0.712 0.288 0.000
T33-T35 Frostbite
0.712 0.288 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.712 0.288 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.712 0.288 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.712 0.288 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.712 0.288 0.000
T00-T07 Injuries involving multiple body regions
0.712 0.288 0.000
S10-S19 Injuries to the neck
0.712 0.288 0.000
J90-J94 Other diseases of pleura
0.712 0.288 0.000
C18.2 Ascending colon
0.711 0.289 0.000
I42 Cardiomyopathy
0.711 0.289 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.710 0.289 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.710 0.289 0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.710 0.289 0.000
C17 Malignant neoplasm of small intestine
0.710 0.289 0.000
C23 Malignant neoplasm of gallbladder
0.710 0.289 0.000
N18.5 Chronic kidney disease, stage 5
0.710 0.290 0.000
I74.9 Embolism and thrombosis of unspecified artery
0.709 0.291 0.000
I15 Secondary hypertension
0.709 0.291 0.000
I13 Hypertensive heart and renal disease
0.709 0.291 0.000
I11 Hypertensive heart disease
0.709 0.291 0.000
T87 Complications peculiar to reattachment and amputation
0.708 0.292 0.000
T86 Failure and rejection of transplanted organs and tissues
0.708 0.292 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.708 0.292 0.000
E85 Amyloidosis
0.708 0.292 0.000
E84 Cystic fibrosis
0.708 0.292 0.000
E79 Disorders of purine and pyrimidine metabolism
0.708 0.292 0.000
E77 Disorders of glycoprotein metabolism
0.708 0.292 0.000
E76 Disorders of glycosaminoglycan metabolism
0.708 0.292 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.708 0.292 0.000
E74 Other disorders of carbohydrate metabolism
0.708 0.292 0.000
E73 Lactose intolerance
0.708 0.292 0.000
E72 Other disorders of amino-acid metabolism
0.708 0.292 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.708 0.292 0.000
E70 Disorders of aromatic amino-acid metabolism
0.708 0.292 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.708 0.292 0.000
E13 Other specified diabetes mellitus
0.708 0.292 0.000
E12 Malnutrition-related diabetes mellitus
0.708 0.292 0.000
F33 Recurrent depressive disorder
0.708 0.292 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.707 0.293 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.707 0.293 0.000
E87.4 Mixed disorder of acid-base balance
0.707 0.293 0.000
E87.3 Alkalosis
0.707 0.293 0.000
E87.0 Hyperosmolality and hypernatraemia
0.707 0.293 0.000
D80-D89 Certain disorders involving the immune mechanism
0.707 0.293 0.000
D18 Haemangioma and lymphangioma, any site
0.707 0.293 0.000
N10 Acute tubulo-interstitial nephritis
0.706 0.294 0.000
I44.6 Other and unspecified fascicular block
0.706 0.294 0.000
I44.5 Left posterior fascicular block
0.706 0.294 0.000
I44.4 Left anterior fascicular block
0.706 0.294 0.000
I44.3 Other and unspecified atrioventricular block
0.706 0.294 0.000
E50-E64 Other nutritional deficiencies
0.706 0.294 0.000
N72 Inflammatory disease of cervix uteri
0.705 0.295 0.000
F31.0 Bipolar affective disorder, current episode hypomanic
0.704 0.296 0.000
D23.9 Skin, unspecified
0.703 0.297 0.000
D23.2 Skin of ear and external auricular canal
0.703 0.297 0.000
D23.0 Skin of lip
0.703 0.297 0.000
H35.3 Degeneration of macula and posterior pole
0.703 0.297 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.702 0.297 0.000
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms
0.701 0.299 0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft
0.701 0.299 0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts
0.701 0.299 0.000
T84.3 Mechanical complication of other bone devices, implants and grafts
0.701 0.299 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.701 0.299 0.000
I12.9 Hypertensive renal disease without renal failure
0.700 0.299 0.000
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum
0.700 0.300 0.000
M51.2 Other specified intervertebral disk displacement
0.700 0.300 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.700 0.300 0.000
M65-M68 Disorders of synovium and tendon
0.700 0.300 0.000
E16.2 Hypoglycaemia, unspecified
0.699 0.301 0.000
S70-S79 Injuries to the hip and thigh
0.699 0.301 0.000
I51 Complications and ill-defined descriptions of heart disease
0.699 0.301 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.698 0.301 0.000
F70-F79 Mental retardation
0.698 0.301 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.698 0.301 0.000
I67.1 Cerebral aneurysm, nonruptured
0.698 0.302 0.000
S52 Fracture of forearm
0.697 0.303 0.000
E11.8 With unspecified complications
0.697 0.303 0.000
E11.7 With multiple complications
0.697 0.303 0.000
E11.1 With ketoacidosis
0.697 0.303 0.000
E11.0 With coma
0.697 0.303 0.000
N77 Vulvovaginal ulceration and inflammation in diseases classified elsewhere
0.697 0.303 0.000
H02.8 Other specified disorders of eyelid
0.697 0.303 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.696 0.304 0.000
C18.4 Transverse colon
0.696 0.304 0.000
F29 Unspecified nonorganic psychosis
0.696 0.304 0.000
D17.9 Benign lipomatous neoplasm, unspecified
0.696 0.304 0.000
T66-T78 Other and unspecified effects of external causes
0.694 0.306 0.000
C15.9 Oesophagus, unspecified
0.693 0.307 0.000
N75 Diseases of Bartholin's gland
0.692 0.308 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.692 0.308 0.000
N07 Hereditary nephropathy, not elsewhere classified
0.691 0.309 0.000
N06 Isolated proteinuria with specified morphological lesion
0.691 0.309 0.000
N05 Unspecified nephritic syndrome
0.691 0.309 0.000
N01 Rapidly progressive nephritic syndrome
0.691 0.309 0.000
N00 Acute nephritic syndrome
0.691 0.309 0.000
C64-C68 Malignant neoplasms of urinary tract
0.688 0.312 0.000
C80 Malignant neoplasm without specification of site
0.688 0.312 0.000
N63 Unspecified lump in breast
0.688 0.312 0.000
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms
0.687 0.313 0.000
I95.9 Hypotension, unspecified
0.687 0.313 0.000
M79.7 Fibromyalgia
0.687 0.313 0.000
M14 Arthropathies in other diseases classified elsewhere
0.687 0.313 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.687 0.313 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.686 0.314 0.000
M79.8 Other specified soft tissue disorders
0.683 0.317 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.683 0.317 0.000
D68 Other coagulation defects
0.681 0.318 0.000
C18.8 Overlapping lesion of colon
0.681 0.319 0.000
C18.6 Descending colon
0.681 0.319 0.000
C18.1 Appendix
0.681 0.319 0.000
H02.1 Ectropion of eyelid
0.681 0.319 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.681 0.319 0.000
N11 Chronic tubulo-interstitial nephritis
0.680 0.320 0.000
N64.5 Other signs and symptoms in breast
0.680 0.320 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.679 0.321 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.678 0.322 0.000
B35-B49 Mycoses
0.678 0.322 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.677 0.323 0.000
C16 Malignant neoplasm of stomach
0.677 0.323 0.000
S29 Other and unspecified injuries of thorax
0.677 0.323 0.000
D12.9 Anus and anal canal
0.677 0.323 0.000
D12.1 Appendix
0.677 0.323 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.675 0.325 0.000
H05 Disorders of orbit
0.675 0.325 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.675 0.325 0.000
D17.2 Benign lipomatous neoplasm of skin and subcutaneous tissue of limbs
0.675 0.325 0.000
M91-M94 Chondropathies
0.675 0.325 0.000
M60-M63 Disorders of muscles
0.675 0.325 0.000
M00-M03 Infectious arthropathies
0.675 0.325 0.000
I45 Other conduction disorders
0.674 0.325 0.000
A09 Diarrhoea and gastro-enteritis of presumed infectious origin
0.674 0.326 0.000
C77.1 Intrathoracic lymph nodes
0.674 0.326 0.000
S80 Superficial injury of lower leg
0.671 0.329 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.670 0.330 0.000
E10.3 With ophthalmic complications
0.669 0.331 0.000
I46 Cardiac arrest
0.668 0.331 0.000
N02 Recurrent and persistent haematuria
0.667 0.333 0.000
N74 Female pelvic inflammatory disorders in diseases classified elsewhere
0.666 0.334 0.000
N71 Inflammatory disease of uterus, except cervix
0.666 0.334 0.000
I67.9 Cerebrovascular disease, unspecified
0.666 0.334 0.000
I95.2 Hypotension due to drugs
0.666 0.334 0.000
D17.5 Benign lipomatous neoplasm of intra-abdominal organs
0.665 0.334 0.000
D55-D59 Haemolytic anaemias
0.665 0.335 0.000
S40-S49 Injuries to the shoulder and upper arm
0.665 0.335 0.000
D03 Melanoma in situ
0.665 0.335 0.000
I63 Cerebral infarction
0.665 0.335 0.000
C78.2 Secondary malignant neoplasm of pleura
0.664 0.336 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.663 0.337 0.000
M80-M85 Disorders of bone density and structure
0.663 0.337 0.000
D22.1 Melanocytic naevi of eyelid, including canthus
0.663 0.337 0.000
M05 Seropositive rheumatoid arthritis
0.662 0.338 0.000
M72 Fibroblastic disorders
0.662 0.338 0.000
E66.8 Other obesity
0.662 0.338 0.000
D22.3 Melanocytic naevi of other and unspecified parts of face
0.661 0.339 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.661 0.339 0.000
Y35-Y36 Legal intervention and operations of war
0.661 0.339 0.000
Y10-Y34 Event of undetermined intent
0.661 0.339 0.000
Y00-Y09 Assault
0.661 0.339 0.000
X85-X99 Assault
0.661 0.339 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.661 0.339 0.000
X50-X57 Overexertion, travel and privation
0.661 0.339 0.000
X30-X39 Exposure to forces of nature
0.661 0.339 0.000
X20-X29 Contact with venomous animals and plants
0.661 0.339 0.000
X10-X19 Contact with heat and hot substances
0.661 0.339 0.000
X00-X09 Exposure to smoke, fire and flames
0.661 0.339 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.661 0.339 0.000
W75-W84 Other accidental threats to breathing
0.661 0.339 0.000
W65-W74 Accidental drowning and submersion
0.661 0.339 0.000
W50-W64 Exposure to animate mechanical forces
0.661 0.339 0.000
V98-V99 Other and unspecified transport accidents
0.661 0.339 0.000
V95-V97 Air and space transport accidents
0.661 0.339 0.000
V90-V94 Water transport accidents
0.661 0.339 0.000
V80-V89 Other land transport accidents
0.661 0.339 0.000
V70-V79 Bus occupant injured in transport accident
0.661 0.339 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.661 0.339 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.661 0.339 0.000
V40-V49 Car occupant injured in transport accident
0.661 0.339 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.661 0.339 0.000
V20-V29 Motorcycle rider injured in transport accident
0.661 0.339 0.000
V01-V09 Pedestrian injured in transport accident
0.661 0.339 0.000
D04 Carcinoma in situ of skin
0.661 0.339 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.661 0.339 0.000
T84.1 Mechanical complication of internal fixation device of bones of limb
0.660 0.340 0.000
B15-B19 Viral hepatitis
0.659 0.341 0.000
H04 Disorders of lachrymal system
0.658 0.342 0.000
B99-B99 Other infectious diseases
0.658 0.342 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.658 0.342 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.658 0.342 0.000
B50-B64 Protozoal diseases
0.658 0.342 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.658 0.342 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.658 0.342 0.000
A80-A89 Viral infections of the central nervous system
0.658 0.342 0.000
A75-A79 Rickettsioses
0.658 0.342 0.000
A70-A74 Other diseases caused by chlamydiae
0.658 0.342 0.000
A65-A69 Other spirochaetal diseases
0.658 0.342 0.000
A20-A28 Certain zoonotic bacterial diseases
0.658 0.342 0.000
A15-A19 Tuberculosis
0.658 0.342 0.000
E83 Disorders of mineral metabolism
0.657 0.343 0.000
F38 Other mood [affective] disorders
0.657 0.343 0.000
F34 Persistent mood [affective] disorders
0.657 0.343 0.000
F30 Manic episode
0.657 0.343 0.000
F39 Unspecified mood [affective] disorder
0.657 0.343 0.000
I70 Atherosclerosis
0.656 0.343 0.000
H60-H62 Diseases of external ear
0.655 0.345 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.655 0.345 0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.654 0.346 0.000
D22.9 Melanocytic naevi, unspecified
0.653 0.347 0.000
D22.2 Melanocytic naevi of ear and external auricular canal
0.653 0.347 0.000
D22.0 Melanocytic naevi of lip
0.653 0.347 0.000
H02.6 Xanthelasma of eyelid
0.653 0.347 0.000
I98 Other disorders of circulatory system in diseases classified elsewhere
0.652 0.348 0.000
G20-G26 Extrapyramidal and movement disorders
0.652 0.348 0.000
M50 Cervical disk disorders
0.652 0.348 0.000
D67 Hereditary factor IX deficiency
0.651 0.349 0.000
D66 Hereditary factor VIII deficiency
0.651 0.349 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.651 0.349 0.000
C60-C63 Malignant neoplasms of male genital organs
0.651 0.349 0.000
M40-M43 Deforming dorsopathies
0.650 0.349 0.000
D17.3 Benign lipomatous neoplasm of skin and subcutaneous tissue of other and unspecified sites
0.650 0.350 0.000
M07 Psoriatic and enteropathic arthropathies
0.649 0.350 0.000
T17 Foreign body in respiratory tract
0.649 0.351 0.000
N73.9 Female pelvic inflammatory disease, unspecified
0.648 0.352 0.000
D17.1 Benign lipomatous neoplasm of skin and subcutaneous tissue of trunk
0.648 0.352 0.000
A04 Other bacterial intestinal infections
0.646 0.354 0.000
W20-W49 Exposure to inanimate mechanical forces
0.646 0.354 0.000
T85.2 Mechanical complication of intraocular lens
0.646 0.354 0.000
E10.4 With neurological complications
0.645 0.354 0.000
I74.5 Embolism and thrombosis of iliac artery
0.645 0.355 0.000
H00.1 Chalazion
0.645 0.355 0.000
M06.0 Seronegative rheumatoid arthritis
0.645 0.355 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.644 0.356 0.000
D17.6 Benign lipomatous neoplasm of spermatic cord
0.644 0.356 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.644 0.356 0.000
Y83.5 Amputation of limb(s)
0.643 0.357 0.000
Y83.0 Surgical operation with transplant of whole organ
0.643 0.357 0.000
H43 Disorders of vitreous body
0.643 0.357 0.000
I47.2 Ventricular tachycardia
0.642 0.358 0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs
0.642 0.358 0.000
C78.5 Secondary malignant neoplasm of large intestine and rectum
0.642 0.358 0.000
C78.4 Secondary malignant neoplasm of small intestine
0.642 0.358 0.000
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs
0.642 0.358 0.000
C78.1 Secondary malignant neoplasm of mediastinum
0.642 0.358 0.000
N18.0 End-stage renal disease
0.640 0.360 0.000
N18.8 Other chronic renal failure
0.640 0.360 0.000
N18.1 Chronic kidney disease, stage 1
0.640 0.360 0.000
H36.0 Diabetic retinopathy
0.640 0.360 0.000
D69.9 Haemorrhagic condition, unspecified
0.640 0.360 0.000
D69.8 Other specified haemorrhagic conditions
0.640 0.360 0.000
D69.5 Secondary thrombocytopenia
0.640 0.360 0.000
D69.4 Other primary thrombocytopenia
0.640 0.360 0.000
D69.2 Other nonthrombocytopenic purpura
0.640 0.360 0.000
D69.1 Qualitative platelet defects
0.640 0.360 0.000
D69.0 Allergic purpura
0.640 0.360 0.000
H35.0 Background retinopathy and retinal vascular changes
0.640 0.360 0.000
D32 Benign neoplasm of meninges
0.639 0.360 0.000
F32 Depressive episode
0.639 0.361 0.000
N17.9 Acute renal failure, unspecified
0.639 0.361 0.000
C77.4 Inguinal and lower limb lymph nodes
0.637 0.363 0.000
I77.1 Stricture of artery
0.637 0.363 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.637 0.363 0.000
I95.1 Orthostatic hypotension
0.637 0.363 0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease
0.636 0.364 0.000
H02.7 Other degenerative disorders of eyelid and periocular area
0.636 0.364 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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