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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs114906368
log Bayes Factor = 18.504
Chromosome 5   position 109,299,290  (GRCh37) Explore rs114906368 on Ensembl!
Variant rs114906368 is part of Cluster X0161

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter II Neoplasms
1.000 0.000 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter VIII Diseases of the ear and mastoid process
0.991 0.009 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.989 0.011 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.988 0.012 0.000
Chapter XIV Diseases of the genitourinary system
0.988 0.012 0.000
Chapter I Certain infectious and parasitic diseases
0.987 0.013 0.000
C79 Secondary malignant neoplasm of other sites
0.987 0.013 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.986 0.014 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.986 0.014 0.000
Chapter V Mental and behavioural disorders
0.981 0.019 0.000
E70-E90 Metabolic disorders
0.980 0.020 0.000
H65-H75 Diseases of middle ear and mastoid
0.974 0.026 0.000
Chapter XX External causes of morbidity and mortality
0.972 0.028 0.000
C78.7 Secondary malignant neoplasm of liver
0.970 0.030 0.000
C15-C26 Malignant neoplasms of digestive organs
0.969 0.031 0.000
C78.0 Secondary malignant neoplasm of lung
0.968 0.032 0.000
N60-N64 Disorders of breast
0.967 0.033 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.966 0.034 0.000
Chapter IX Diseases of the circulatory system
0.958 0.042 0.000
B35-B49 Mycoses
0.954 0.046 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.951 0.049 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.948 0.052 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.946 0.054 0.000
N17-N19 Renal failure
0.944 0.056 0.000
N60 Benign mammary dysplasia
0.940 0.060 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.939 0.061 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.939 0.061 0.000
C78.2 Secondary malignant neoplasm of pleura
0.939 0.061 0.000
Chapter XI Diseases of the digestive system
0.936 0.064 0.000
B37 Candidiasis
0.931 0.069 0.000
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum
0.930 0.070 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.929 0.071 0.000
R26 Abnormalities of gait and mobility
0.926 0.074 0.000
C51-C58 Malignant neoplasms of female genital organs
0.925 0.075 0.000
N17 Acute renal failure
0.923 0.077 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.922 0.078 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.921 0.079 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.921 0.079 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.919 0.081 0.000
B95-B98 Bacterial, viral and other infectious agents
0.918 0.082 0.000
C79.5 Secondary malignant neoplasm of bone and bone marrow
0.918 0.082 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.915 0.085 0.000
N17.9 Acute renal failure, unspecified
0.909 0.091 0.000
E50-E64 Other nutritional deficiencies
0.906 0.094 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.904 0.096 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.904 0.096 0.000
C18 Malignant neoplasm of colon
0.900 0.100 0.000
Y43 Primarily systemic agents
0.900 0.100 0.000
C77.1 Intrathoracic lymph nodes
0.896 0.104 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.895 0.105 0.000
C77.0 Lymph nodes of head, face and neck
0.892 0.108 0.000
H72 Perforation of tympanic membrane
0.889 0.111 0.000
R26.8 Other and unspecified abnormalities of gait and mobility
0.886 0.114 0.000
E87.5 Hyperkalaemia
0.886 0.114 0.000
I60-I69 Cerebrovascular diseases
0.885 0.115 0.000
Chapter VI Diseases of the nervous system
0.885 0.115 0.000
E83 Disorders of mineral metabolism
0.884 0.116 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.884 0.116 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.883 0.117 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.881 0.119 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.878 0.122 0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.875 0.125 0.000
K70-K77 Diseases of liver
0.874 0.126 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.873 0.127 0.000
I10-I15 Hypertensive diseases
0.871 0.129 0.000
C15 Malignant neoplasm of oesophagus
0.870 0.130 0.000
E89.0 Postprocedural hypothyroidism
0.868 0.132 0.000
C71 Malignant neoplasm of brain
0.861 0.139 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.859 0.141 0.000
M80-M85 Disorders of bone density and structure
0.858 0.142 0.000
C77.9 Lymph node, unspecified
0.857 0.143 0.000
R41.0 Disorientation, unspecified
0.856 0.144 0.000
N00-N08 Glomerular diseases
0.854 0.146 0.000
B37.0 Candidal stomatitis
0.852 0.148 0.000
K50-K52 Noninfective enteritis and colitis
0.852 0.148 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.849 0.151 0.000
T43.2 Other and unspecified antidepressants
0.848 0.152 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.847 0.153 0.000
E53 Deficiency of other B group vitamins
0.846 0.154 0.000
H90-H95 Other disorders of ear
0.846 0.154 0.000
C79.8 Secondary malignant neoplasm of other specified sites
0.841 0.159 0.000
H60-H62 Diseases of external ear
0.840 0.160 0.000
S60-S69 Injuries to the wrist and hand
0.839 0.161 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.838 0.162 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.838 0.162 0.000
Chapter X Diseases of the respiratory system
0.837 0.163 0.000
N70-N77 Inflammatory diseases of female pelvic organs
0.837 0.163 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.836 0.164 0.000
D60-D64 Aplastic and other anaemias
0.835 0.165 0.000
Y52 Agents primarily affecting the cardiovascular system
0.832 0.168 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.831 0.169 0.000
N63 Unspecified lump in breast
0.827 0.173 0.000
B37.9 Candidiasis, unspecified
0.825 0.175 0.000
C79.6 Secondary malignant neoplasm of ovary
0.823 0.177 0.000
C77.5 Intrapelvic lymph nodes
0.820 0.180 0.000
E83.4 Disorders of magnesium metabolism
0.820 0.180 0.000
I12 Hypertensive renal disease
0.819 0.181 0.000
Y43.3 Other antineoplastic drugs
0.817 0.183 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.816 0.183 0.000
I30-I52 Other forms of heart disease
0.817 0.183 0.000
H71 Cholesteatoma of middle ear
0.816 0.184 0.000
R93.3 Abnormal findings on diagnostic imaging of other parts of digestive tract
0.815 0.185 0.000
H73 Other disorders of tympanic membrane
0.814 0.186 0.000
F60-F69 Disorders of adult personality and behaviour
0.814 0.186 0.000
K51 Ulcerative colitis
0.813 0.187 0.000
K08 Other disorders of teeth and supporting structures
0.813 0.187 0.000
N60.1 Diffuse cystic mastopathy
0.812 0.188 0.000
H66 Suppurative and unspecified otitis media
0.810 0.190 0.000
S00-S09 Injuries to the head
0.807 0.193 0.000
H72.9 Perforation of tympanic membrane, unspecified
0.807 0.193 0.000
C64-C68 Malignant neoplasms of urinary tract
0.806 0.194 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.806 0.194 0.000
E53.8 Deficiency of other specified B group vitamins
0.803 0.197 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.803 0.197 0.000
R45 Symptoms and signs involving emotional state
0.799 0.201 0.000
F30-F39 Mood [affective] disorders
0.798 0.202 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.795 0.205 0.000
W20-W49 Exposure to inanimate mechanical forces
0.795 0.205 0.000
I69 Sequelae of cerebrovascular disease
0.794 0.206 0.000
E87.2 Acidosis
0.792 0.208 0.000
J40-J47 Chronic lower respiratory diseases
0.792 0.208 0.000
N60.4 Mammary duct ectasia
0.791 0.209 0.000
M65-M68 Disorders of synovium and tendon
0.789 0.211 0.000
E86 Volume depletion
0.789 0.211 0.000
Chapter XXII Codes for special purposes
0.789 0.211 0.000
M20-M25 Other joint disorders
0.788 0.212 0.000
B95.1 Streptococcus, group B, as the cause of diseases classified to other chapters
0.787 0.213 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.786 0.214 0.000
Y43.1 Antineoplastic antimetabolites
0.786 0.214 0.000
A00-A09 Intestinal infectious diseases
0.785 0.215 0.000
N60.0 Solitary cyst of breast
0.784 0.216 0.000
K01 Embedded and impacted teeth
0.784 0.216 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.782 0.218 0.000
C71.9 Brain, unspecified
0.781 0.219 0.000
C78.5 Secondary malignant neoplasm of large intestine and rectum
0.780 0.220 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.778 0.222 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.778 0.222 0.000
M70-M79 Other soft tissue disorders
0.778 0.222 0.000
T39.1 4-Aminophenol derivatives
0.776 0.224 0.000
C18.2 Ascending colon
0.775 0.225 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.775 0.225 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.775 0.225 0.000
I12.0 Hypertensive renal disease with renal failure
0.773 0.227 0.000
V20-V29 Motorcycle rider injured in transport accident
0.772 0.228 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.771 0.229 0.000
K08.3 Retained dental root
0.770 0.230 0.000
C77.8 Lymph nodes of multiple regions
0.768 0.232 0.000
N60.3 Fibrosclerosis of breast
0.768 0.232 0.000
G35 Multiple sclerosis
0.767 0.233 0.000
R91 Abnormal findings on diagnostic imaging of lung
0.767 0.233 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.766 0.234 0.000
C56 Malignant neoplasm of ovary
0.766 0.234 0.000
C15.5 Lower third of oesophagus
0.765 0.235 0.000
J44 Other chronic obstructive pulmonary disease
0.765 0.235 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.765 0.235 0.000
N99-N99 Other disorders of the genitourinary system
0.765 0.235 0.000
C25 Malignant neoplasm of pancreas
0.765 0.235 0.000
E88 Other metabolic disorders
0.764 0.236 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.764 0.236 0.000
N60.8 Other benign mammary dysplasias
0.763 0.237 0.000
I47 Paroxysmal tachycardia
0.762 0.238 0.000
H74 Other disorders of middle ear and mastoid
0.761 0.239 0.000
T39.0 Salicylates
0.760 0.240 0.000
T79-T79 Certain early complications of trauma
0.760 0.240 0.000
F01 Vascular dementia
0.759 0.240 0.000
F03 Unspecified dementia
0.759 0.241 0.000
B37.8 Candidiasis of other sites
0.756 0.244 0.000
D61 Other aplastic anaemias
0.754 0.246 0.000
F99-F99 Unspecified mental disorder
0.754 0.246 0.000
I26 Pulmonary embolism
0.753 0.247 0.000
C79.2 Secondary malignant neoplasm of skin
0.753 0.247 0.000
S70-S79 Injuries to the hip and thigh
0.750 0.250 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.749 0.251 0.000
C77.4 Inguinal and lower limb lymph nodes
0.749 0.251 0.000
M81 Osteoporosis without pathological fracture
0.749 0.251 0.000
T88.4 Failed or difficult intubation
0.748 0.252 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.746 0.253 0.000
I63 Cerebral infarction
0.747 0.253 0.000
L20-L30 Dermatitis and eczema
0.746 0.254 0.000
R29.6 Tendency to fall, not elsewhere classified
0.745 0.255 0.000
X60-X84 Intentional self-harm
0.745 0.255 0.000
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
0.745 0.255 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.744 0.256 0.000
I31 Other diseases of pericardium
0.743 0.257 0.000
C80 Malignant neoplasm without specification of site
0.743 0.257 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.743 0.257 0.000
M23 Internal derangement of knee
0.740 0.260 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.739 0.261 0.000
S90-S99 Injuries to the ankle and foot
0.739 0.261 0.000
C51 Malignant neoplasm of vulva
0.739 0.261 0.000
C18.0 Caecum
0.739 0.261 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.736 0.263 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
0.736 0.264 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.736 0.264 0.000
M80 Osteoporosis with pathological fracture
0.736 0.264 0.000
G90-G99 Other disorders of the nervous system
0.734 0.266 0.000
K05 Gingivitis and periodontal diseases
0.733 0.267 0.000
H92 Otalgia and effusion of ear
0.732 0.267 0.000
C53 Malignant neoplasm of cervix uteri
0.732 0.268 0.000
B95.5 Unspecified streptococcus as the cause of diseases classified to other chapters
0.732 0.268 0.000
N72 Inflammatory disease of cervix uteri
0.731 0.269 0.000
R90 Abnormal findings on diagnostic imaging of central nervous system
0.731 0.269 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.730 0.270 0.000
J44.9 Chronic obstructive pulmonary disease, unspecified
0.730 0.270 0.000
S01 Open wound of head
0.730 0.270 0.000
K14 Diseases of tongue
0.729 0.271 0.000
I49 Other cardiac arrhythmias
0.727 0.273 0.000
K12 Stomatitis and related lesions
0.726 0.274 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.726 0.274 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.726 0.274 0.000
G37 Other demyelinating diseases of central nervous system
0.726 0.274 0.000
E40-E46 Malnutrition
0.725 0.275 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.725 0.275 0.000
R26.3 Immobility
0.725 0.275 0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.724 0.276 0.000
N61 Inflammatory disorders of breast
0.724 0.276 0.000
N25-N29 Other disorders of kidney and ureter
0.724 0.276 0.000
R94 Abnormal results of function studies
0.723 0.277 0.000
K76 Other diseases of liver
0.723 0.277 0.000
A80-A89 Viral infections of the central nervous system
0.722 0.278 0.000
S20-S29 Injuries to the thorax
0.722 0.278 0.000
L02 Cutaneous abscess, furuncle and carbuncle
0.722 0.278 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.721 0.279 0.000
E20-E35 Disorders of other endocrine glands
0.720 0.279 0.000
C71.2 Temporal lobe
0.720 0.279 0.000
S40-S49 Injuries to the shoulder and upper arm
0.720 0.280 0.000
B37.3 Candidiasis of vulva and vagina
0.718 0.282 0.000
K51.9 Ulcerative colitis, unspecified
0.718 0.282 0.000
T66-T78 Other and unspecified effects of external causes
0.718 0.282 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.717 0.283 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.717 0.283 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.717 0.283 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.717 0.283 0.000
C78.4 Secondary malignant neoplasm of small intestine
0.717 0.283 0.000
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs
0.717 0.283 0.000
C78.1 Secondary malignant neoplasm of mediastinum
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
S10-S19 Injuries to the neck
0.717 0.283 0.000
H65 Nonsuppurative otitis media
0.717 0.283 0.000
J42 Unspecified chronic bronchitis
0.717 0.283 0.000
B95.7 Other staphylococcus as the cause of diseases classified to other chapters
0.716 0.283 0.000
K11 Diseases of salivary glands
0.716 0.284 0.000
C18.9 Colon, unspecified
0.716 0.284 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.715 0.285 0.000
B15-B19 Viral hepatitis
0.715 0.285 0.000
K75 Other inflammatory liver diseases
0.715 0.285 0.000
K72 Hepatic failure, not elsewhere classified
0.714 0.286 0.000
K51.2 Ulcerative (chronic) proctitis
0.714 0.286 0.000
C54 Malignant neoplasm of corpus uteri
0.714 0.286 0.000
C55 Malignant neoplasm of uterus, part unspecified
0.712 0.287 0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs
0.712 0.288 0.000
K70 Alcoholic liver disease
0.710 0.290 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.709 0.291 0.000
Y52.4 Angiotensin-converting-enzyme inhibitors
0.709 0.291 0.000
C16 Malignant neoplasm of stomach
0.709 0.291 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.708 0.291 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.708 0.291 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.708 0.291 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.708 0.291 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.708 0.291 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.708 0.291 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.708 0.291 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.708 0.291 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.708 0.291 0.000
T36 Poisoning by systemic antibiotics
0.708 0.291 0.000
R93.2 Abnormal findings on diagnostic imaging of liver and biliary tract
0.708 0.292 0.000
N30-N39 Other diseases of urinary system
0.708 0.292 0.000
R93.0 Abnormal findings on diagnostic imaging of skull and head, not elsewhere classified
0.708 0.292 0.000
B99-B99 Other infectious diseases
0.708 0.292 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.708 0.292 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.708 0.292 0.000
B65-B83 Helminthiases
0.708 0.292 0.000
B50-B64 Protozoal diseases
0.708 0.292 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.708 0.292 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.708 0.292 0.000
A75-A79 Rickettsioses
0.708 0.292 0.000
A70-A74 Other diseases caused by chlamydiae
0.708 0.292 0.000
A65-A69 Other spirochaetal diseases
0.708 0.292 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.708 0.292 0.000
A20-A28 Certain zoonotic bacterial diseases
0.708 0.292 0.000
A15-A19 Tuberculosis
0.708 0.292 0.000
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system
0.707 0.292 0.000
C79.1 Secondary malignant neoplasm of bladder and other and unspecified urinary organs
0.707 0.292 0.000
C79.0 Secondary malignant neoplasm of kidney and renal pelvis
0.707 0.292 0.000
B95.0 Streptococcus, group A, as the cause of diseases classified to other chapters
0.707 0.293 0.000
H66.3 Other chronic suppurative otitis media
0.707 0.293 0.000
R45.8 Other symptoms and signs involving emotional state
0.707 0.293 0.000
I47.1 Supraventricular tachycardia
0.706 0.294 0.000
N03 Chronic nephritic syndrome
0.706 0.294 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.703 0.296 0.000
F80-F89 Disorders of psychological development
0.703 0.296 0.000
F70-F79 Mental retardation
0.703 0.296 0.000
E85 Amyloidosis
0.703 0.297 0.000
E84 Cystic fibrosis
0.703 0.297 0.000
E79 Disorders of purine and pyrimidine metabolism
0.703 0.297 0.000
E77 Disorders of glycoprotein metabolism
0.703 0.297 0.000
E76 Disorders of glycosaminoglycan metabolism
0.703 0.297 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.703 0.297 0.000
E74 Other disorders of carbohydrate metabolism
0.703 0.297 0.000
E73 Lactose intolerance
0.703 0.297 0.000
E72 Other disorders of amino-acid metabolism
0.703 0.297 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.703 0.297 0.000
E70 Disorders of aromatic amino-acid metabolism
0.703 0.297 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.703 0.297 0.000
F10 Mental and behavioural disorders due to use of alcohol
0.702 0.298 0.000
C15.9 Oesophagus, unspecified
0.702 0.298 0.000
S80-S89 Injuries to the knee and lower leg
0.700 0.300 0.000
R23 Other skin changes
0.700 0.300 0.000
H73.8 Other specified disorders of tympanic membrane
0.700 0.300 0.000
H72.8 Other perforations of tympanic membrane
0.700 0.300 0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.698 0.302 0.000
H70 Mastoiditis and related conditions
0.698 0.302 0.000
H69 Other disorders of Eustachian tube
0.698 0.302 0.000
H68 Eustachian salpingitis and obstruction
0.698 0.302 0.000
H67 Otitis media in diseases classified elsewhere
0.698 0.302 0.000
K06 Other disorders of gingiva and edentulous alveolar ridge
0.698 0.302 0.000
Q80-Q89 Other congenital malformations
0.698 0.302 0.000
L60-L75 Disorders of skin appendages
0.698 0.302 0.000
I05-I09 Chronic rheumatic heart diseases
0.697 0.303 0.000
K01.1 Impacted teeth
0.697 0.303 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.697 0.303 0.000
Y35-Y36 Legal intervention and operations of war
0.697 0.303 0.000
Y10-Y34 Event of undetermined intent
0.697 0.303 0.000
Y00-Y09 Assault
0.697 0.303 0.000
X85-X99 Assault
0.697 0.303 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.697 0.303 0.000
X50-X57 Overexertion, travel and privation
0.697 0.303 0.000
X30-X39 Exposure to forces of nature
0.697 0.303 0.000
X20-X29 Contact with venomous animals and plants
0.697 0.303 0.000
X10-X19 Contact with heat and hot substances
0.697 0.303 0.000
X00-X09 Exposure to smoke, fire and flames
0.697 0.303 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.697 0.303 0.000
W75-W84 Other accidental threats to breathing
0.697 0.303 0.000
W65-W74 Accidental drowning and submersion
0.697 0.303 0.000
W50-W64 Exposure to animate mechanical forces
0.697 0.303 0.000
V98-V99 Other and unspecified transport accidents
0.697 0.303 0.000
V95-V97 Air and space transport accidents
0.697 0.303 0.000
V90-V94 Water transport accidents
0.697 0.303 0.000
V80-V89 Other land transport accidents
0.697 0.303 0.000
V70-V79 Bus occupant injured in transport accident
0.697 0.303 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.697 0.303 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.697 0.303 0.000
V40-V49 Car occupant injured in transport accident
0.697 0.303 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.697 0.303 0.000
V01-V09 Pedestrian injured in transport accident
0.697 0.303 0.000
E87.0 Hyperosmolality and hypernatraemia
0.697 0.303 0.000
Chapter XXI Factors influencing health status and contact with health services
0.696 0.304 0.000
D61.9 Aplastic anaemia, unspecified
0.696 0.304 0.000
L91 Hypertrophic disorders of skin
0.696 0.304 0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.695 0.305 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.695 0.305 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.695 0.305 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.695 0.305 0.000
C21 Malignant neoplasm of anus and anal canal
0.695 0.305 0.000
C17 Malignant neoplasm of small intestine
0.695 0.305 0.000
C23 Malignant neoplasm of gallbladder
0.695 0.305 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.695 0.305 0.000
F60 Specific personality disorders
0.695 0.305 0.000
B95.4 Other streptococcus as the cause of diseases classified to other chapters
0.694 0.306 0.000
I27 Other pulmonary heart diseases
0.694 0.306 0.000
C64 Malignant neoplasm of kidney, except renal pelvis
0.694 0.306 0.000
R40 Somnolence, stupor and coma
0.692 0.308 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.692 0.308 0.000
M65 Synovitis and tenosynovitis
0.691 0.309 0.000
F43 Reaction to severe stress, and adjustment disorders
0.691 0.309 0.000
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.691 0.309 0.000
H60 Otitis externa
0.690 0.310 0.000
E83.5 Disorders of calcium metabolism
0.690 0.310 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.690 0.310 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.689 0.311 0.000
T17 Foreign body in respiratory tract
0.689 0.311 0.000
I60 Subarachnoid haemorrhage
0.688 0.312 0.000
R26.2 Difficulty in walking, not elsewhere classified
0.687 0.312 0.000
I00-I02 Acute rheumatic fever
0.687 0.313 0.000
A04 Other bacterial intestinal infections
0.687 0.313 0.000
I67 Other cerebrovascular diseases
0.686 0.314 0.000
C18.6 Descending colon
0.684 0.315 0.000
B48 Other mycoses, not elsewhere classified
0.684 0.316 0.000
B47 Mycetoma
0.684 0.316 0.000
B46 Zygomycosis
0.684 0.316 0.000
B45 Cryptococcosis
0.684 0.316 0.000
B44 Aspergillosis
0.684 0.316 0.000
B43 Chromomycosis and phaeomycotic abscess
0.684 0.316 0.000
B42 Sporotrichosis
0.684 0.316 0.000
B41 Paracoccidioidomycosis
0.684 0.316 0.000
B40 Blastomycosis
0.684 0.316 0.000
B39 Histoplasmosis
0.684 0.316 0.000
B38 Coccidioidomycosis
0.684 0.316 0.000
B36 Other superficial mycoses
0.684 0.316 0.000
B35 Dermatophytosis
0.684 0.316 0.000
B49 Unspecified mycosis
0.684 0.316 0.000
C79.7 Secondary malignant neoplasm of adrenal gland
0.684 0.316 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.684 0.316 0.000
B95.8 Unspecified staphylococcus as the cause of diseases classified to other chapters
0.682 0.318 0.000
Y59 Other and unspecified vaccines and biological substances
0.682 0.318 0.000
Y58 Bacterial vaccines
0.682 0.318 0.000
Y57 Other and unspecified drugs and medicaments
0.682 0.318 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.682 0.318 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.682 0.318 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.682 0.318 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.682 0.318 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.682 0.318 0.000
Y48 Anaesthetics and therapeutic gases
0.682 0.318 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.682 0.318 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.682 0.318 0.000
Y44 Agents primarily affecting blood constituents
0.682 0.318 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.682 0.318 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.681 0.319 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.681 0.319 0.000
R25 Abnormal involuntary movements
0.680 0.320 0.000
Q60-Q64 Congenital malformations of the urinary system
0.680 0.320 0.000
R92 Abnormal findings on diagnostic imaging of breast
0.680 0.320 0.000
K65-K67 Diseases of peritoneum
0.680 0.320 0.000
E65-E68 Obesity and other hyperalimentation
0.679 0.321 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.678 0.322 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.678 0.322 0.000
T39.4 Antirheumatics, not elsewhere classified
0.678 0.322 0.000
T39.2 Pyrazolone derivatives
0.678 0.322 0.000
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.678 0.322 0.000
T88.7 Unspecified adverse effect of drug or medicament
0.678 0.322 0.000
T88.8 Other specified complications of surgical and medical care, not elsewhere classified
0.677 0.323 0.000
I62 Other nontraumatic intracranial haemorrhage
0.676 0.324 0.000
R47-R49 Symptoms and signs involving speech and voice
0.675 0.325 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.674 0.326 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.674 0.326 0.000
N60.9 Benign mammary dysplasia, unspecified
0.674 0.326 0.000
T43.9 Psychotropic drug, unspecified
0.674 0.326 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.674 0.326 0.000
T43.6 Psychostimulants with abuse potential
0.674 0.326 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.674 0.326 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.674 0.326 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.674 0.326 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.674 0.326 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.673 0.326 0.000
E87.4 Mixed disorder of acid-base balance
0.673 0.326 0.000
E87.3 Alkalosis
0.673 0.326 0.000
T93 Sequelae of injuries of lower limb
0.671 0.329 0.000
N10-N16 Renal tubulo-interstitial diseases
0.670 0.330 0.000
E61 Deficiency of other nutrient elements
0.670 0.330 0.000
G40-G47 Episodic and paroxysmal disorders
0.670 0.330 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.670 0.330 0.000
I31.3 Pericardial effusion (noninflammatory)
0.670 0.330 0.000
M23.22 Derangement of meniscus due to old tear or injury (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.669 0.331 0.000
C18.4 Transverse colon
0.668 0.332 0.000
H61 Other disorders of external ear
0.668 0.332 0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified
0.668 0.332 0.000
B37.7 Candidal septicaemia
0.667 0.333 0.000
B37.6 Candidal endocarditis
0.667 0.333 0.000
B37.5 Candidal meningitis
0.667 0.333 0.000
B37.4 Candidiasis of other urogenital sites
0.667 0.333 0.000
B37.2 Candidiasis of skin and nail
0.667 0.333 0.000
B37.1 Pulmonary candidiasis
0.667 0.333 0.000
R46 Symptoms and signs involving appearance and behaviour
0.666 0.334 0.000
R43 Disturbances of smell and taste
0.666 0.334 0.000
N18 Chronic renal failure
0.666 0.334 0.000
M86-M90 Other osteopathies
0.665 0.335 0.000
D64 Other anaemias
0.665 0.335 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.665 0.335 0.000
R26.1 Paralytic gait
0.664 0.336 0.000
R26.0 Ataxic gait
0.664 0.336 0.000
N76 Other inflammation of vagina and vulva
0.663 0.336 0.000
C57 Malignant neoplasm of other and unspecified female genital organs
0.663 0.337 0.000
C58 Malignant neoplasm of placenta
0.663 0.337 0.000
C52 Malignant neoplasm of vagina
0.663 0.337 0.000
N64 Other disorders of breast
0.662 0.337 0.000
N17.8 Other acute renal failure
0.662 0.338 0.000
N17.2 Acute renal failure with medullary necrosis
0.662 0.338 0.000
N17.1 Acute renal failure with acute cortical necrosis
0.662 0.338 0.000
N17.0 Acute renal failure with tubular necrosis
0.662 0.338 0.000
M84 Disorders of continuity of bone
0.661 0.338 0.000
L10-L14 Bullous disorders
0.661 0.339 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.660 0.340 0.000
M91-M94 Chondropathies
0.660 0.340 0.000
M60-M63 Disorders of muscles
0.660 0.340 0.000
M00-M03 Infectious arthropathies
0.660 0.340 0.000
T87 Complications peculiar to reattachment and amputation
0.660 0.340 0.000
T86 Failure and rejection of transplanted organs and tissues
0.660 0.340 0.000
M81.9 Osteoporosis, unspecified
0.660 0.340 0.000
C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system
0.659 0.341 0.000
C70 Malignant neoplasm of meninges
0.659 0.341 0.000
C69 Malignant neoplasm of eye and adnexa
0.659 0.341 0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.659 0.341 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.659 0.341 0.000
F01.9 Vascular dementia, unspecified
0.656 0.344 0.000
N62 Hypertrophy of breast
0.656 0.344 0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.656 0.344 0.000
E89.8 Other postprocedural endocrine and metabolic disorders
0.656 0.344 0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.656 0.344 0.000
E89.5 Postprocedural testicular hypofunction
0.656 0.344 0.000
E89.4 Postprocedural ovarian failure
0.656 0.344 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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