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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs11577931
log Bayes Factor = 38.4581
Chromosome 1   position 109,820,884  (GRCh37) Explore rs11577931 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
I20.9 Angina pectoris, unspecified
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
I20 Angina pectoris
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
E78.5 Hyperlipidaemia, unspecified
0.000 0.000 1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.001 0.999
I25.2 Old myocardial infarction
0.000 0.001 0.999
I20.0 Unstable angina
0.000 0.001 0.999
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.002 0.998
I21 Acute myocardial infarction
0.000 0.002 0.998
I21.9 Acute myocardial infarction, unspecified
0.000 0.003 0.997
I50 Heart failure
0.000 0.017 0.983
I50.0 Congestive heart failure
0.000 0.023 0.977
Chapter IX Diseases of the circulatory system
0.000 0.024 0.976
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.028 0.972
I30-I52 Other forms of heart disease
0.000 0.028 0.972
I50.1 Left ventricular failure
0.000 0.033 0.967
I71 Aortic aneurysm and dissection
0.000 0.054 0.946
I50.9 Heart failure, unspecified
0.000 0.064 0.936
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.000 0.066 0.934
I73 Other peripheral vascular diseases
0.000 0.090 0.910
I45 Other conduction disorders
0.000 0.108 0.892
I73.9 Peripheral vascular disease, unspecified
0.000 0.108 0.892
I25.3 Aneurysm of heart
0.000 0.115 0.885
I45.1 Other and unspecified right bundle-branch block
0.000 0.124 0.876
Z95.1 Presence of aortocoronary bypass graft
0.000 0.128 0.872
I71.3 Abdominal aortic aneurysm, ruptured
0.000 0.137 0.863
I21.4 Acute subendocardial myocardial infarction
0.000 0.152 0.848
I34 Nonrheumatic mitral valve disorders
0.000 0.160 0.840
I72 Other aneurysm
0.000 0.160 0.840
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.175 0.825
I24 Other acute ischaemic heart diseases
0.000 0.208 0.792
E78.8 Other disorders of lipoprotein metabolism
0.000 0.225 0.775
I74 Arterial embolism and thrombosis
0.000 0.226 0.774
I33 Acute and subacute endocarditis
0.000 0.228 0.772
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.231 0.769
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.236 0.764
I42 Cardiomyopathy
0.000 0.238 0.762
I77 Other disorders of arteries and arterioles
0.000 0.255 0.745
I34.1 Mitral (valve) prolapse
0.000 0.263 0.737
I23 Certain current complications following acute myocardial infarction
0.000 0.277 0.723
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.281 0.719
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.283 0.717
E78.6 Lipoprotein deficiency
0.000 0.283 0.716
E78.3 Hyperchylomicronaemia
0.000 0.283 0.716
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.284 0.715
I72.3 Aneurysm of iliac artery
0.000 0.287 0.713
I38 Endocarditis, valve unspecified
0.000 0.288 0.712
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.289 0.711
I20.8 Other forms of angina pectoris
0.000 0.290 0.710
E78.1 Pure hyperglyceridaemia
0.000 0.291 0.709
I72.4 Aneurysm of artery of lower extremity
0.000 0.294 0.706
I00-I02 Acute rheumatic fever
0.000 0.300 0.699
I52 Other heart disorders in diseases classified elsewhere
0.000 0.303 0.697
I48 Atrial fibrillation and flutter
0.000 0.303 0.697
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.303 0.697
I41 Myocarditis in diseases classified elsewhere
0.000 0.303 0.697
I40 Acute myocarditis
0.000 0.303 0.697
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.303 0.697
I32 Pericarditis in diseases classified elsewhere
0.000 0.303 0.697
I45.5 Other specified heart block
0.000 0.308 0.692
I24.8 Other forms of acute ischaemic heart disease
0.000 0.308 0.692
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.317 0.683
I33.0 Acute and subacute infective endocarditis
0.000 0.320 0.680
I71.8 Aortic aneurysm of unspecified site, ruptured
0.000 0.322 0.678
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.000 0.322 0.678
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.000 0.322 0.678
I71.1 Thoracic aortic aneurysm, ruptured
0.000 0.322 0.678
E78.4 Other hyperlipidaemia
0.000 0.329 0.671
I46 Cardiac arrest
0.000 0.329 0.671
I25.4 Coronary artery aneurysm
0.000 0.332 0.668
I73.8 Other specified peripheral vascular diseases
0.000 0.333 0.667
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.000 0.335 0.665
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.336 0.664
I45.3 Trifascicular block
0.000 0.339 0.661
I05-I09 Chronic rheumatic heart diseases
0.000 0.340 0.660
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.348 0.652
I45.0 Right fascicular block
0.000 0.360 0.639
I42.9 Cardiomyopathy, unspecified
0.000 0.365 0.635
I25.5 Ischaemic cardiomyopathy
0.000 0.366 0.634
Z95.8 Presence of other cardiac and vascular implants and grafts
0.000 0.367 0.633
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.371 0.629
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.373 0.627
I45.2 Bifascicular block
0.000 0.379 0.621
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.381 0.618
I42.6 Alcoholic cardiomyopathy
0.000 0.383 0.617
I71.0 Dissection of aorta [any part]
0.000 0.384 0.616
I45.8 Other specified conduction disorders
0.000 0.384 0.616
I35 Nonrheumatic aortic valve disorders
0.000 0.388 0.612
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.392 0.608
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.393 0.607
I36 Nonrheumatic tricuspid valve disorders
0.000 0.393 0.606
I34.8 Other nonrheumatic mitral valve disorders
0.000 0.398 0.602
I72.6 Aneurysm and dissection of vertebral artery
0.000 0.398 0.602
I72.5 Aneurysm and dissection of other precerebral arteries
0.000 0.398 0.602
I72.2 Aneurysm of renal artery
0.000 0.398 0.602
I72.1 Aneurysm of artery of upper extremity
0.000 0.398 0.602
I42.2 Other hypertrophic cardiomyopathy
0.000 0.398 0.602
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.404 0.596
I42.8 Other cardiomyopathies
0.000 0.405 0.595
I72.8 Aneurysm of other specified arteries
0.000 0.407 0.593
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.409 0.591
I79.1 Aortitis in diseases classified elsewhere
0.000 0.409 0.591
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.409 0.591
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.415 0.585
I34.2 Nonrheumatic mitral (valve) stenosis
0.000 0.418 0.582
I72.0 Aneurysm of carotid artery
0.000 0.418 0.582
I35.0 Aortic (valve) stenosis
0.000 0.425 0.575
I77.8 Other specified disorders of arteries and arterioles
0.000 0.428 0.572
I34.0 Mitral (valve) insufficiency
0.000 0.431 0.569
I24.1 Dressler's syndrome
0.000 0.432 0.568
I45.6 Preexcitation syndrome
0.000 0.434 0.565
I37 Pulmonary valve disorders
0.000 0.440 0.559
I72.9 Aneurysm of unspecified site
0.000 0.443 0.557
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.445 0.555
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.445 0.555
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.445 0.555
I22 Subsequent myocardial infarction
0.000 0.446 0.554
I20.1 Angina pectoris with documented spasm
0.000 0.447 0.553
I78 Diseases of capillaries
0.000 0.453 0.547
I42.7 Cardiomyopathy due to drugs and other external agents
0.000 0.453 0.546
I42.5 Other restrictive cardiomyopathy
0.000 0.453 0.546
I42.4 Endocardial fibroelastosis
0.000 0.453 0.546
I42.3 Endomyocardial (eosinophilic) disease
0.000 0.453 0.546
I77.0 Arteriovenous fistula, acquired
0.000 0.460 0.540
I05 Rheumatic mitral valve diseases
0.000 0.460 0.540
I77.6 Arteritis, unspecified
0.000 0.462 0.538
Z95.4 Presence of other heart-valve replacement
0.000 0.465 0.535
I77.5 Necrosis of artery
0.000 0.466 0.534
I77.4 Coeliac artery compression syndrome
0.000 0.466 0.534
I77.3 Arterial fibromuscular dysplasia
0.000 0.466 0.534
I77.2 Rupture of artery
0.000 0.466 0.534
I07 Rheumatic tricuspid valve diseases
0.000 0.467 0.533
I30 Acute pericarditis
0.000 0.468 0.531
Z95.3 Presence of xenogenic heart valve
0.000 0.469 0.531
I23.8 Other current complications following acute myocardial infarction
0.000 0.475 0.525
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.481 0.518
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.481 0.518
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.481 0.518
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.481 0.518
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.481 0.518
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.481 0.518
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.481 0.518
I74.8 Embolism and thrombosis of other arteries
0.000 0.486 0.514
I46.0 Cardiac arrest with successful resuscitation
0.000 0.491 0.509
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.000 0.493 0.507
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.495 0.504
I02 Rheumatic chorea
0.000 0.498 0.501
I01 Rheumatic fever with heart involvement
0.000 0.498 0.501
I00 Rheumatic fever without mention of heart involvement
0.000 0.498 0.501
I32.8 Pericarditis in other diseases classified elsewhere
0.000 0.500 0.500
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.500 0.500
I32.0 Pericarditis in bacterial diseases classified elsewhere
0.000 0.500 0.500
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere
0.000 0.500 0.500
I39.4 Multiple valve disorders in diseases classified elsewhere
0.000 0.500 0.500
I39.3 Pulmonary valve disorders in diseases classified elsewhere
0.000 0.500 0.500
I39.2 Tricuspid valve disorders in diseases classified elsewhere
0.000 0.500 0.500
I39.1 Aortic valve disorders in diseases classified elsewhere
0.000 0.500 0.500
I39.0 Mitral valve disorders in diseases classified elsewhere
0.000 0.500 0.500
I40.9 Acute myocarditis, unspecified
0.000 0.500 0.500
I40.8 Other acute myocarditis
0.000 0.500 0.500
I40.1 Isolated myocarditis
0.000 0.500 0.500
I40.0 Infective myocarditis
0.000 0.500 0.500
I41.8 Myocarditis in other diseases classified elsewhere
0.000 0.500 0.500
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.500 0.500
I41.1 Myocarditis in viral diseases classified elsewhere
0.000 0.500 0.500
I41.0 Myocarditis in bacterial diseases classified elsewhere
0.000 0.500 0.500
I43.8 Cardiomyopathy in other diseases classified elsewhere
0.000 0.500 0.500
I43.2 Cardiomyopathy in nutritional diseases
0.000 0.500 0.500
I43.1 Cardiomyopathy in metabolic diseases
0.000 0.500 0.500
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere
0.000 0.500 0.500
I48.9 Atrial fibrillation and atrial flutter, unspecified
0.000 0.500 0.500
I48.4 Atypical atrial flutter
0.000 0.500 0.500
I48.3 Typical atrial flutter
0.000 0.500 0.500
I48.2 Chronic atrial fibrillation
0.000 0.500 0.500
I48.1 Persistent atrial fibrillation
0.000 0.500 0.500
I48.0 Paroxysmal atrial fibrillation
0.000 0.500 0.500
I52.8 Other heart disorders in other diseases classified elsewhere
0.000 0.500 0.500
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.500 0.500
I52.0 Other heart disorders in bacterial diseases classified elsewhere
0.000 0.500 0.500
I74.5 Embolism and thrombosis of iliac artery
0.000 0.514 0.486
I46.1 Sudden cardiac death, so described
0.000 0.519 0.481
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.520 0.480
I31 Other diseases of pericardium
0.000 0.524 0.476
I06 Rheumatic aortic valve diseases
0.000 0.527 0.473
E78.2 Mixed hyperlipidaemia
0.000 0.527 0.473
I35.8 Other aortic valve disorders
0.000 0.528 0.471
I77.1 Stricture of artery
0.000 0.532 0.468
I45.4 Nonspecific intraventricular block
0.001 0.536 0.464
I09 Other rheumatic heart diseases
0.000 0.537 0.463
I70 Atherosclerosis
0.001 0.548 0.451
I05.2 Mitral stenosis with insufficiency
0.000 0.554 0.446
I07.1 Tricuspid insufficiency
0.000 0.558 0.442
Z95.2 Presence of prosthetic heart valve
0.000 0.561 0.439
I36.9 Nonrheumatic tricuspid valve disorder, unspecified
0.000 0.565 0.435
I36.8 Other nonrheumatic tricuspid valve disorders
0.000 0.565 0.435
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency
0.000 0.565 0.435
I36.0 Nonrheumatic tricuspid (valve) stenosis
0.000 0.565 0.435
I33.9 Acute endocarditis, unspecified
0.000 0.567 0.433
I45.9 Conduction disorder, unspecified
0.000 0.576 0.424
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.577 0.423
I46.9 Cardiac arrest, unspecified
0.000 0.581 0.419
I05.0 Mitral stenosis
0.000 0.584 0.415
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.000 0.585 0.415
I42.1 Obstructive hypertrophic cardiomyopathy
0.000 0.586 0.413
Z95.0 Presence of cardiac pacemaker
0.000 0.590 0.410
I60-I69 Cerebrovascular diseases
0.000 0.591 0.409
I37.9 Pulmonary valve disorder, unspecified
0.000 0.598 0.401
I37.8 Other pulmonary valve disorders
0.000 0.598 0.401
I37.2 Pulmonary valve stenosis with insufficiency
0.000 0.598 0.401
I37.0 Pulmonary valve stenosis
0.000 0.598 0.401
I78.8 Other diseases of capillaries
0.000 0.599 0.401
I78.9 Disease of capillaries, unspecified
0.000 0.607 0.392
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.000 0.609 0.391
I05.8 Other mitral valve diseases
0.000 0.613 0.387
I05.1 Rheumatic mitral insufficiency
0.000 0.613 0.387
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.616 0.384
I07.9 Tricuspid valve disease, unspecified
0.000 0.618 0.382
I07.8 Other tricuspid valve diseases
0.000 0.618 0.382
I07.2 Tricuspid stenosis with insufficiency
0.000 0.618 0.382
I07.0 Tricuspid stenosis
0.000 0.618 0.382
I49 Other cardiac arrhythmias
0.000 0.618 0.382
I30.8 Other forms of acute pericarditis
0.000 0.619 0.381
I30.0 Acute nonspecific idiopathic pericarditis
0.000 0.619 0.381
I65.2 Occlusion and stenosis of carotid artery
0.000 0.622 0.378
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.625 0.374
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.626 0.374
I35.9 Aortic valve disorder, unspecified
0.000 0.629 0.371
I05.9 Mitral valve disease, unspecified
0.000 0.630 0.370
I69 Sequelae of cerebrovascular disease
0.000 0.631 0.369
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.640 0.360
I01.8 Other acute rheumatic heart disease
0.000 0.640 0.360
I01.2 Acute rheumatic myocarditis
0.000 0.640 0.360
I01.1 Acute rheumatic endocarditis
0.000 0.640 0.360
I01.0 Acute rheumatic pericarditis
0.000 0.640 0.360
I02.9 Rheumatic chorea without heart involvement
0.000 0.640 0.360
I02.0 Rheumatic chorea with heart involvement
0.000 0.640 0.360
I51 Complications and ill-defined descriptions of heart disease
0.000 0.643 0.357
I42.0 Dilated cardiomyopathy
0.000 0.644 0.356
I22.8 Subsequent myocardial infarction of other sites
0.000 0.645 0.355
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.646 0.353
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.000 0.655 0.344
I28 Other diseases of pulmonary vessels
0.000 0.655 0.344
I31.8 Other specified diseases of pericardium
0.000 0.658 0.341
I31.2 Haemopericardium, not elsewhere classified
0.000 0.658 0.341
I31.1 Chronic constrictive pericarditis
0.000 0.658 0.341
I31.0 Chronic adhesive pericarditis
0.000 0.658 0.341
I30.1 Infective pericarditis
0.000 0.660 0.340
I06.9 Rheumatic aortic valve disease, unspecified
0.000 0.661 0.339
I06.8 Other rheumatic aortic valve diseases
0.000 0.661 0.339
I06.2 Rheumatic aortic stenosis with insufficiency
0.000 0.661 0.339
I06.1 Rheumatic aortic insufficiency
0.000 0.661 0.339
I06.0 Rheumatic aortic stenosis
0.000 0.661 0.339
I09.8 Other specified rheumatic heart diseases
0.000 0.668 0.332
I09.2 Chronic rheumatic pericarditis
0.000 0.668 0.332
I09.1 Rheumatic diseases of endocardium, valve unspecified
0.000 0.668 0.332
I09.0 Rheumatic myocarditis
0.000 0.668 0.332
I70.9 Generalised and unspecified atherosclerosis
0.001 0.676 0.323
I70.8 Atherosclerosis of other arteries
0.001 0.676 0.323
I09.9 Rheumatic heart disease, unspecified
0.000 0.677 0.322
I49.1 Atrial premature depolarisation
0.000 0.680 0.320
I60 Subarachnoid haemorrhage
0.000 0.681 0.319
I47 Paroxysmal tachycardia
0.000 0.683 0.317
I49.5 Sick sinus syndrome
0.000 0.685 0.315
I69.3 Sequelae of cerebral infarction
0.000 0.688 0.312
I69.0 Sequelae of subarachnoid haemorrhage
0.000 0.688 0.312
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.000 0.694 0.306
I27 Other pulmonary heart diseases
0.000 0.695 0.305
I70.1 Atherosclerosis of renal artery
0.001 0.704 0.296
I60.9 Subarachnoid haemorrhage, unspecified
0.000 0.706 0.294
I68 Cerebrovascular disorders in diseases classified elsewhere
0.000 0.706 0.293
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.708 0.291
I31.3 Pericardial effusion (noninflammatory)
0.000 0.712 0.288
I99 Other and unspecified disorders of circulatory system
0.000 0.713 0.287
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.001 0.715 0.283
I65.0 Occlusion and stenosis of vertebral artery
0.000 0.716 0.284
I30.9 Acute pericarditis, unspecified
0.000 0.716 0.283
I65.9 Occlusion and stenosis of unspecified precerebral artery
0.000 0.719 0.281
I65.8 Occlusion and stenosis of other precerebral artery
0.000 0.719 0.281
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries
0.000 0.719 0.281
I65.1 Occlusion and stenosis of basilar artery
0.000 0.719 0.281
I51.6 Cardiovascular disease, unspecified
0.000 0.725 0.275
I49.2 Junctional premature depolarisation
0.000 0.726 0.274
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.000 0.735 0.265
I37.1 Pulmonary valve insufficiency
0.001 0.735 0.264
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.000 0.737 0.263
I49.4 Other and unspecified premature depolarisation
0.000 0.738 0.262
I51.7 Cardiomegaly
0.000 0.743 0.257
I78.1 Naevus, nonneoplastic
0.000 0.743 0.257
I70.2 Atherosclerosis of arteries of the extremities
0.001 0.743 0.257
I51.5 Myocardial degeneration
0.000 0.744 0.256
I51.2 Rupture of papillary muscle, not elsewhere classified
0.000 0.744 0.256
I49.8 Other specified cardiac arrhythmias
0.000 0.747 0.253
I70.0 Atherosclerosis of aorta
0.001 0.750 0.249
I60.2 Subarachnoid haemorrhage from anterior communicating artery
0.000 0.751 0.249
I28.9 Disease of pulmonary vessels, unspecified
0.000 0.753 0.247
I28.8 Other specified diseases of pulmonary vessels
0.000 0.753 0.247
I28.1 Aneurysm of pulmonary artery
0.000 0.753 0.247
I28.0 Arteriovenous fistula of pulmonary vessels
0.000 0.753 0.247
I51.8 Other ill-defined heart diseases
0.000 0.756 0.244
I35.2 Aortic (valve) stenosis with insufficiency
0.000 0.756 0.243
I73.0 Raynaud's syndrome
0.000 0.758 0.242
I69.2 Sequelae of other nontraumatic intracranial haemorrhage
0.000 0.758 0.241
I69.1 Sequelae of intracerebral haemorrhage
0.000 0.759 0.241
I51.3 Intracardiac thrombosis, not elsewhere classified
0.000 0.764 0.236
I67 Other cerebrovascular diseases
0.000 0.764 0.236
I51.0 Cardiac septal defect, acquired
0.000 0.767 0.233
I70.81 Atherosclerosis of other arteries (with gangrene)
0.001 0.767 0.232
I70.80 Atherosclerosis of other arteries (without gangrene)
0.001 0.767 0.232
I70.91 Generalized and unspecified atherosclerosis (with gangrene)
0.001 0.767 0.232
I70.90 Generalized and unspecified atherosclerosis (without gangrene)
0.001 0.767 0.232
I60.7 Subarachnoid haemorrhage from intracranial artery, unspecified
0.000 0.771 0.228
I60.5 Subarachnoid haemorrhage from vertebral artery
0.000 0.771 0.228
I60.4 Subarachnoid haemorrhage from basilar artery
0.000 0.771 0.228
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation
0.000 0.771 0.228
I51.4 Myocarditis, unspecified
0.000 0.773 0.226
I47.9 Paroxysmal tachycardia, unspecified
0.000 0.777 0.222
I31.9 Disease of pericardium, unspecified
0.000 0.778 0.222
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.000 0.778 0.221
I10-I15 Hypertensive diseases
0.000 0.780 0.220
I27.0 Primary pulmonary hypertension
0.000 0.781 0.219
I27.1 Kyphoscoliotic heart disease
0.000 0.781 0.219
I27.8 Other specified pulmonary heart diseases
0.000 0.781 0.219
I60.6 Subarachnoid haemorrhage from other intracranial arteries
0.000 0.783 0.216
I27.9 Pulmonary heart disease, unspecified
0.000 0.784 0.216
I49.0 Ventricular fibrillation and flutter
0.000 0.785 0.215
I70.11 Atherosclerosis of renal artery (with gangrene)
0.001 0.787 0.212
I67.2 Cerebral atherosclerosis
0.000 0.789 0.211
I68.8 Other cerebrovascular disorders in diseases classified elsewhere
0.000 0.789 0.210
I68.2 Cerebral arteritis in other diseases classified elsewhere
0.000 0.789 0.210
I68.1 Cerebral arteritis in infectious and parasitic diseases classified elsewhere
0.000 0.789 0.210
I68.0 Cerebral amyloid angiopathy
0.000 0.789 0.210
I26 Pulmonary embolism
0.000 0.795 0.205
I60.3 Subarachnoid haemorrhage from posterior communicating artery
0.000 0.796 0.204
I66.8 Occlusion and stenosis of other cerebral artery
0.000 0.810 0.190
I66.4 Occlusion and stenosis of multiple and bilateral cerebral arteries
0.000 0.810 0.190
I66.3 Occlusion and stenosis of cerebellar arteries
0.000 0.810 0.190
I66.2 Occlusion and stenosis of posterior cerebral artery
0.000 0.810 0.190
I66.1 Occlusion and stenosis of anterior cerebral artery
0.000 0.810 0.190
I66.0 Occlusion and stenosis of middle cerebral artery
0.000 0.810 0.190
I47.2 Ventricular tachycardia
0.000 0.812 0.188
I47.0 Reentry ventricular arrhythmia
0.000 0.813 0.187
I60.8 Other subarachnoid haemorrhage
0.000 0.813 0.186
I70.10 Atherosclerosis of renal artery (without gangrene)
0.001 0.815 0.184
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.001 0.815 0.184
I27.2 Other secondary pulmonary hypertension
0.000 0.816 0.183
I70.01 Atherosclerosis of aorta (with gangrene)
0.001 0.820 0.179
I62 Other nontraumatic intracranial haemorrhage
0.000 0.822 0.178
I60.1 Subarachnoid haemorrhage from middle cerebral artery
0.000 0.822 0.177
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.001 0.823 0.176
I44 Atrioventricular and left bundle-branch block
0.000 0.827 0.173
I67.7 Cerebral arteritis, not elsewhere classified
0.000 0.831 0.169
I67.6 Nonpyogenic thrombosis of intracranial venous system
0.000 0.831 0.169
I67.5 Moyamoya disease
0.000 0.831 0.169
I67.4 Hypertensive encephalopathy
0.000 0.831 0.169
I67.3 Progressive vascular leukoencephalopathy
0.000 0.831 0.169
I49.9 Cardiac arrhythmia, unspecified
0.000 0.833 0.167
I51.9 Heart disease, unspecified
0.000 0.833 0.167
I08 Multiple valve diseases
0.000 0.833 0.167
I67.9 Cerebrovascular disease, unspecified
0.000 0.836 0.164
I66.9 Occlusion and stenosis of unspecified cerebral artery
0.000 0.838 0.162
I95 Hypotension
0.000 0.839 0.161
I13 Hypertensive heart and renal disease
0.000 0.842 0.158
I98 Other disorders of circulatory system in diseases classified elsewhere
0.001 0.843 0.156
I26.0 Pulmonary embolism with mention of acute cor pulmonale
0.000 0.853 0.147
I67.0 Dissection of cerebral arteries, nonruptured
0.000 0.857 0.142
I15 Secondary hypertension
0.000 0.861 0.139
I95.1 Orthostatic hypotension
0.000 0.866 0.134
I11 Hypertensive heart disease
0.000 0.869 0.131
I67.8 Other specified cerebrovascular diseases
0.000 0.869 0.131
I62.1 Nontraumatic extradural haemorrhage
0.000 0.872 0.128
I44.6 Other and unspecified fascicular block
0.000 0.872 0.127
I97.9 Postprocedural disorder of circulatory system, unspecified
0.001 0.873 0.126
I97.0 Postcardiotomy syndrome
0.001 0.873 0.126
I44.5 Left posterior fascicular block
0.000 0.876 0.124
I44.4 Left anterior fascicular block
0.000 0.876 0.124
I12 Hypertensive renal disease
0.000 0.877 0.123
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.000 0.878 0.122
I97.1 Other functional disturbances following cardiac surgery
0.001 0.878 0.122
I08.9 Multiple valve disease, unspecified
0.000 0.880 0.120
I44.1 Atrioventricular block, second degree
0.000 0.881 0.118
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.001 0.882 0.117
I61 Intracerebral haemorrhage
0.000 0.883 0.116
I95.0 Idiopathic hypotension
0.000 0.885 0.115
I08.2 Disorders of both aortic and tricuspid valves
0.000 0.886 0.114
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.886 0.113
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.886 0.113
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.886 0.113
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.886 0.113
I97.2 Postmastectomy lymphoedema syndrome
0.001 0.887 0.112
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.001 0.887 0.112
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.001 0.887 0.112
I98.0 Cardiovascular syphilis
0.001 0.887 0.112
M75.0 Adhesive capsulitis of shoulder
0.000 0.890 0.110
M75 Shoulder lesions
0.000 0.890 0.110
I35.1 Aortic (valve) insufficiency
0.001 0.892 0.107
I70.00 Atherosclerosis of aorta (without gangrene)
0.001 0.894 0.104
M75.4 Impingement syndrome of shoulder
0.000 0.895 0.105
I47.1 Supraventricular tachycardia
0.000 0.896 0.104
I08.8 Other multiple valve diseases
0.000 0.897 0.103
I44.3 Other and unspecified atrioventricular block
0.000 0.898 0.102
I95.2 Hypotension due to drugs
0.000 0.898 0.101
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.001 0.899 0.100
I15.9 Seconday hypertension, unspecified
0.000 0.900 0.100
I15.8 Other secondary hypertension
0.000 0.900 0.100
I15.2 Hypertension secondary to endocrine disorders
0.000 0.900 0.100
I15.0 Renovascular hypertension
0.000 0.900 0.100
M75.5 Bursitis of shoulder
0.000 0.901 0.099
I95.8 Other hypotension
0.000 0.901 0.098
M75.1 Rotator cuff syndrome
0.000 0.902 0.098
I63 Cerebral infarction
0.000 0.902 0.098
I12.9 Hypertensive renal disease without renal failure
0.000 0.903 0.097
I62.9 Intracranial haemorrhage (nontraumatic), unspecified
0.001 0.903 0.096
I67.1 Cerebral aneurysm, nonruptured
0.000 0.904 0.096
M75.3 Calcific tendinitis of shoulder
0.000 0.905 0.095
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.906 0.094
I49.3 Ventricular premature depolarisation
0.001 0.908 0.091
I44.2 Atrioventricular block, complete
0.000 0.912 0.088
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified
0.001 0.913 0.086
I61.6 Intracerebral haemorrhage, multiple localised
0.000 0.916 0.084
I61.3 Intracerebral haemorrhage in brain stem
0.000 0.916 0.084
I44.7 Left bundle-branch block, unspecified
0.000 0.916 0.084
M75.9 Shoulder lesion, unspecified
0.000 0.918 0.082
I15.1 Hypertension secondary to other renal disorders
0.000 0.919 0.081
I61.2 Intracerebral haemorrhage in hemisphere, unspecified
0.000 0.920 0.080
I61.5 Intracerebral haemorrhage, intraventricular
0.000 0.920 0.079
M75.8 Other shoulder lesions
0.000 0.921 0.079
I61.1 Intracerebral haemorrhage in hemisphere, cortical
0.000 0.923 0.077
I62.0 Subdural haemorrhage (acute) (nontraumatic)
0.001 0.923 0.076
I61.0 Intracerebral haemorrhage in hemisphere, subcortical
0.000 0.925 0.074
I61.4 Intracerebral haemorrhage in cerebellum
0.000 0.926 0.073
I63.4 Cerebral infarction due to embolism of cerebral arteries
0.000 0.928 0.072
Z82.4 Family history of ischaemic heart disease and other diseases of the circulatory system
0.000 0.928 0.072
I08.0 Disorders of both mitral and aortic valves
0.000 0.928 0.071
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic
0.000 0.930 0.070
I63.1 Cerebral infarction due to embolism of precerebral arteries
0.000 0.930 0.070
I63.0 Cerebral infarction due to thrombosis of precerebral arteries
0.000 0.930 0.070
I61.8 Other intracerebral haemorrhage
0.000 0.932 0.068
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
0.000 0.932 0.068
I63.8 Other cerebral infarction
0.000 0.932 0.068
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.933 0.067
M75.2 Bicipital tendinitis
0.000 0.940 0.060
I61.9 Intracerebral haemorrhage, unspecified
0.000 0.940 0.059
M75.81 Other shoulder lesions, right shoulder
0.000 0.943 0.057
I44.0 Atrioventricular block, first degree
0.000 0.944 0.056
I63.3 Cerebral infarction due to thrombosis of cerebral arteries
0.000 0.944 0.056
I08.1 Disorders of both mitral and tricuspid valves
0.000 0.953 0.047
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
0.000 0.953 0.047
I98.2 Oesophageal varices in diseases classified elsewhere
0.002 0.954 0.045
I64 Stroke, not specified as haemorrhage or infarction
0.001 0.955 0.045
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified
0.041 0.959 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.040 0.960 0.000
T85.4 Mechanical complication of breast prosthesis and implant
0.037 0.963 0.000
I10 Essential (primary) hypertension
0.000 0.964 0.036
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.036 0.964 0.000
T85.2 Mechanical complication of intraocular lens
0.035 0.964 0.000
T85.3 Mechanical complication of other ocular prosthetic devices, imnplants and grafts
0.034 0.966 0.000
T85.0 Mechanical complication of ventricular intracranial (communicating) shunt
0.033 0.967 0.000
I95.9 Hypotension, unspecified
0.000 0.967 0.033
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.030 0.970 0.000
T85.5 Mechanical complication of gastro-intestinal prosthetic devices, implants and grafts
0.030 0.970 0.000
T85.1 Mechanical complication of implanted electronic stimulator of nervous system
0.030 0.970 0.000
I12.0 Hypertensive renal disease with renal failure
0.000 0.972 0.028
I63.9 Cerebral infarction, unspecified
0.000 0.976 0.024
T85.9 Unspecified complication of internal prosthetic device, implant and graft
0.023 0.976 0.000
Z82 Family history of certain disabilities and chronic diseases leading to disablement
0.000 0.978 0.022
Z82.5 Family history of asthma and other chronic lower respiratory diseases
0.000 0.982 0.018
Z82.6 Family history of arthritis and other diseases of the musculoskeletal system and connective tissue
0.000 0.983 0.017
Z82.8 Family history of other disabilities and chronic diseases leading to disablement, not elsewhere classified
0.000 0.984 0.016
Z82.2 Family history of deafness and hearing loss
0.000 0.984 0.016
M70-M79 Other soft tissue disorders
0.000 0.984 0.016
Z82.7 Family history of congenital malformations, deformations and chromosomal abnormalities
0.000 0.984 0.016
Z30.1 Insertion of (intra-uterine) contraceptive device
0.000 0.984 0.016
Z82.1 Family history of blindness and visual loss
0.000 0.985 0.015
Z82.0 Family history of epilepsy and other diseases of the nervous system
0.000 0.987 0.013
Z93.2 Ileostomy status
0.013 0.987 0.000
E70-E90 Metabolic disorders
0.000 0.988 0.012
M77 Other enthesopathies
0.000 0.988 0.012
M73 Soft tissue disorders in diseases classified elsewhere
0.000 0.988 0.012
Z82.3 Family history of stroke
0.000 0.989 0.011
M76 Enthesopathies of lower limb, excluding foot
0.000 0.989 0.011
M72 Fibroblastic disorders
0.000 0.989 0.011
M70 Soft tissue disorders related to use, overuse and pressure
0.000 0.989 0.010
M77.9 Enthesopathy, unspecified
0.000 0.989 0.010
Z91.1 Personal history of noncompliance with medical treatment and regimen
0.011 0.989 0.000
K25.3 Acute without haemorrhage or perforation
0.010 0.990 0.000
M77.91 Enthesopathy, unspecified (Shoulder region)
0.000 0.991 0.009
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.991 0.009
M77.0 Medial epicondylitis
0.000 0.991 0.009
E84 Cystic fibrosis
0.000 0.991 0.009
E79 Disorders of purine and pyrimidine metabolism
0.000 0.991 0.009
E77 Disorders of glycoprotein metabolism
0.000 0.991 0.009
E76 Disorders of glycosaminoglycan metabolism
0.000 0.991 0.009
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.991 0.009
E74 Other disorders of carbohydrate metabolism
0.000 0.991 0.009
E72 Other disorders of amino-acid metabolism
0.000 0.991 0.009
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.991 0.009

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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