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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs116224392
log Bayes Factor = 11.3558
Chromosome 3   position 69,810,826  (GRCh37) Explore rs116224392 on Ensembl!
Variant rs116224392 is part of Cluster X0041

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter VII Diseases of the eye and adnexa
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
H30-H36 Disorders of choroid and retina
0.999 0.001 0.000
M70-M79 Other soft tissue disorders
0.999 0.001 0.000
Chapter V Mental and behavioural disorders
0.997 0.003 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.997 0.003 0.000
M79.6 Pain in limb
0.997 0.003 0.000
M79.66 Pain in limb (Lower leg)
0.996 0.004 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.992 0.008 0.000
Chapter I Certain infectious and parasitic diseases
0.990 0.010 0.000
H33 Retinal detachments and breaks
0.989 0.011 0.000
Chapter VI Diseases of the nervous system
0.988 0.012 0.000
F30-F39 Mood [affective] disorders
0.985 0.015 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.983 0.017 0.000
H35 Other retinal disorders
0.975 0.025 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.973 0.027 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.968 0.032 0.000
H35.3 Degeneration of macula and posterior pole
0.963 0.037 0.000
M65-M68 Disorders of synovium and tendon
0.962 0.038 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.956 0.044 0.000
F31 Bipolar affective disorder
0.953 0.047 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.953 0.047 0.000
A00-A09 Intestinal infectious diseases
0.951 0.049 0.000
T66-T78 Other and unspecified effects of external causes
0.948 0.052 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.946 0.054 0.000
M80-M85 Disorders of bone density and structure
0.946 0.054 0.000
H33.0 Retinal detachment with retinal break
0.942 0.058 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.940 0.060 0.000
H25-H28 Disorders of lens
0.936 0.064 0.000
S90-S99 Injuries to the ankle and foot
0.933 0.067 0.000
A09 Diarrhoea and gastro-enteritis of presumed infectious origin
0.932 0.068 0.000
S80-S89 Injuries to the knee and lower leg
0.931 0.069 0.000
A09.9 Gastroenteritis and colitis of unspecified origin
0.920 0.080 0.000
M65 Synovitis and tenosynovitis
0.919 0.081 0.000
H26 Other cataract
0.918 0.082 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.916 0.084 0.000
S60-S69 Injuries to the wrist and hand
0.909 0.091 0.000
T42.4 Benzodiazepines
0.906 0.094 0.000
H20 Iridocyclitis
0.905 0.095 0.000
H26.9 Cataract, unspecified
0.902 0.098 0.000
S10-S19 Injuries to the neck
0.902 0.098 0.000
T78 Adverse effects, not elsewhere classified
0.896 0.104 0.000
H18 Other disorders of cornea
0.887 0.113 0.000
B02 Zoster [herpes zoster]
0.877 0.123 0.000
Chapter XX External causes of morbidity and mortality
0.877 0.123 0.000
H02 Other disorders of eyelid
0.876 0.124 0.000
F31.9 Bipolar affective disorder, unspecified
0.873 0.127 0.000
H33.3 Retinal breaks without detachment
0.872 0.128 0.000
H47 Other disorders of optic [2nd] nerve and visual pathways
0.870 0.130 0.000
F33 Recurrent depressive disorder
0.869 0.131 0.000
F03 Unspecified dementia
0.869 0.131 0.000
B35-B49 Mycoses
0.868 0.132 0.000
H40-H42 Glaucoma
0.864 0.136 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.862 0.138 0.000
S81 Open wound of lower leg
0.860 0.139 0.000
S61 Open wound of wrist and hand
0.859 0.141 0.000
G30-G32 Other degenerative diseases of the nervous system
0.856 0.144 0.000
S12 Fracture of neck
0.853 0.147 0.000
H21 Other disorders of iris and ciliary body
0.852 0.148 0.000
G12 Spinal muscular atrophy and related syndromes
0.852 0.148 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.850 0.150 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.850 0.150 0.000
M65.9 Synovitis and tenosynovitis, unspecified
0.850 0.150 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.849 0.151 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.847 0.153 0.000
H20.9 Iridocyclitis, unspecified
0.846 0.154 0.000
G90-G99 Other disorders of the nervous system
0.843 0.157 0.000
T78.4 Allergy, unspecified
0.843 0.157 0.000
H04 Disorders of lachrymal system
0.841 0.159 0.000
S91 Open wound of ankle and foot
0.839 0.161 0.000
M71 Other bursopathies
0.839 0.161 0.000
H33.2 Serous retinal detachment
0.834 0.166 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.832 0.168 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.832 0.168 0.000
B07 Viral warts
0.830 0.170 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.829 0.171 0.000
M77 Other enthesopathies
0.828 0.172 0.000
F31.0 Bipolar affective disorder, current episode hypomanic
0.825 0.175 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.821 0.179 0.000
H02.1 Ectropion of eyelid
0.821 0.179 0.000
M45-M49 Spondylopathies
0.820 0.180 0.000
M79.63 Pain in limb (Forearm)
0.814 0.186 0.000
M40-M43 Deforming dorsopathies
0.814 0.186 0.000
S61.0 Open wound of finger(s) without damage to nail
0.813 0.187 0.000
Q00-Q07 Congenital malformations of the nervous system
0.811 0.189 0.000
F60-F69 Disorders of adult personality and behaviour
0.810 0.190 0.000
T78.2 Anaphylactic shock, unspecified
0.809 0.191 0.000
H33.5 Other retinal detachments
0.809 0.191 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.809 0.191 0.000
Q80-Q89 Other congenital malformations
0.809 0.191 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.808 0.192 0.000
Q60-Q64 Congenital malformations of the urinary system
0.808 0.192 0.000
M80 Osteoporosis with pathological fracture
0.807 0.193 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
0.806 0.194 0.000
G12.2 Motor neuron disease
0.805 0.194 0.000
M84 Disorders of continuity of bone
0.805 0.195 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.803 0.197 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.803 0.197 0.000
S60 Superficial injury of wrist and hand
0.800 0.200 0.000
H04.2 Epiphora
0.799 0.201 0.000
Y60 Unintentional cut, puncture, perforation or haemorrhage during surgical and medical care
0.799 0.201 0.000
B02.9 Zoster without complication
0.798 0.202 0.000
S70-S79 Injuries to the hip and thigh
0.797 0.203 0.000
H18.9 Disorder of cornea, unspecified
0.795 0.205 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.794 0.206 0.000
S81.9 Open wound of lower leg, part unspecified
0.793 0.207 0.000
G93 Other disorders of brain
0.791 0.209 0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease
0.790 0.210 0.000
M79.60 Pain in limb (Multiple sites)
0.788 0.211 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.788 0.212 0.000
A65-A69 Other spirochaetal diseases
0.786 0.214 0.000
M86-M90 Other osteopathies
0.786 0.214 0.000
H35.4 Peripheral retinal degeneration
0.784 0.216 0.000
F80-F89 Disorders of psychological development
0.781 0.219 0.000
M79.9 Soft tissue disorder, unspecified
0.780 0.220 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.778 0.221 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.778 0.222 0.000
M76 Enthesopathies of lower limb, excluding foot
0.778 0.222 0.000
F00 Dementia in Alzheimer's disease
0.777 0.223 0.000
H46 Optic neuritis
0.775 0.225 0.000
M79.8 Other specified soft tissue disorders
0.775 0.225 0.000
A02 Other Salmonella infections
0.771 0.229 0.000
M85 Other disorders of bone density and structure
0.770 0.230 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.769 0.231 0.000
H35.6 Retinal haemorrhage
0.768 0.232 0.000
H40 Glaucoma
0.767 0.233 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.767 0.233 0.000
A08 Viral and other specified intestinal infections
0.766 0.234 0.000
M65.3 Trigger finger
0.766 0.234 0.000
Y60.0 During surgical operation
0.766 0.234 0.000
T39.0 Salicylates
0.764 0.236 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.763 0.237 0.000
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.763 0.237 0.000
F31.7 Bipolar affective disorder, currently in remission
0.760 0.240 0.000
M79.67 Pain in limb (Ankle and foot)
0.760 0.240 0.000
H35.0 Background retinopathy and retinal vascular changes
0.760 0.240 0.000
M45 Ankylosing spondylitis
0.759 0.241 0.000
Q43 Other congenital malformations of intestine
0.758 0.242 0.000
F34 Persistent mood [affective] disorders
0.758 0.242 0.000
S86 Injury of muscle and tendon at lower leg level
0.758 0.242 0.000
H01 Other inflammation of eyelid
0.757 0.243 0.000
H02.0 Entropion and trichiasis of eyelid
0.755 0.245 0.000
T36 Poisoning by systemic antibiotics
0.755 0.245 0.000
S12.1 Fracture of second cervical vertebra
0.755 0.245 0.000
M67 Other disorders of synovium and tendon
0.754 0.246 0.000
T66 Unspecified effects of radiation
0.754 0.246 0.000
S61.1 Open wound of finger(s) with damage to nail
0.752 0.248 0.000
M79.5 Residual foreign body in soft tissue
0.751 0.249 0.000
G40-G47 Episodic and paroxysmal disorders
0.750 0.250 0.000
M79.4 Hypertrophy of (infrapatellar) fat pad
0.750 0.250 0.000
M91-M94 Chondropathies
0.749 0.250 0.000
M20-M25 Other joint disorders
0.750 0.250 0.000
F33.9 Recurrent depressive disorder, unspecified
0.749 0.251 0.000
H35.2 Other proliferative retinopathy
0.748 0.252 0.000
H47.1 Papilloedema, unspecified
0.748 0.252 0.000
S89 Other and unspecified injuries of lower leg
0.748 0.252 0.000
B37 Candidiasis
0.748 0.252 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.747 0.253 0.000
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms
0.746 0.253 0.000
M71.3 Other bursal cyst
0.746 0.254 0.000
S91.3 Open wound of other parts of foot
0.745 0.255 0.000
B00 Herpesviral [herpes simplex] infections
0.743 0.257 0.000
Chapter VIII Diseases of the ear and mastoid process
0.743 0.257 0.000
H26.1 Traumatic cataract
0.743 0.257 0.000
M65.8 Other synovitis and tenosynovitis
0.740 0.260 0.000
M65.94 Synovitis and tenosynovitis, unspecified (Hand)
0.739 0.261 0.000
S40-S49 Injuries to the shoulder and upper arm
0.739 0.261 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.739 0.261 0.000
T43.2 Other and unspecified antidepressants
0.737 0.263 0.000
S61.8 Open wound of other parts of wrist and hand
0.736 0.264 0.000
H21.5 Other adhesions and disruptions of iris and ciliary body
0.735 0.265 0.000
S90 Superficial injury of ankle and foot
0.735 0.265 0.000
T18 Foreign body in alimentary tract
0.735 0.265 0.000
F02 Dementia in other diseases classified elsewhere
0.734 0.266 0.000
G30 Alzheimer's disease
0.734 0.266 0.000
F30 Manic episode
0.733 0.267 0.000
M66 Spontaneous rupture of synovium and tendon
0.733 0.267 0.000
B50-B64 Protozoal diseases
0.733 0.267 0.000
A80-A89 Viral infections of the central nervous system
0.732 0.268 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.732 0.268 0.000
B01 Varicella [chickenpox]
0.732 0.268 0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level
0.731 0.269 0.000
F23 Acute and transient psychotic disorders
0.731 0.269 0.000
M79.61 Pain in limb (Shoulder region)
0.731 0.269 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.730 0.270 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.730 0.270 0.000
G93.6 Cerebral oedema
0.730 0.270 0.000
G70-G73 Diseases of myoneural junction and muscle
0.729 0.271 0.000
M65.97 Synovitis and tenosynovitis, unspecified (Ankle and foot)
0.728 0.272 0.000
M81 Osteoporosis without pathological fracture
0.728 0.272 0.000
F31.4 Bipolar affective disorder, current episode severe depression without psychotic symptoms
0.727 0.273 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.723 0.277 0.000
S12.2 Fracture of other specified cervical vertebra
0.722 0.278 0.000
H40.9 Glaucoma, unspecified
0.722 0.278 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.721 0.279 0.000
F32 Depressive episode
0.721 0.279 0.000
Chapter XXII Codes for special purposes
0.720 0.280 0.000
H18.6 Keratoconus
0.719 0.280 0.000
H27 Other disorders of lens
0.719 0.281 0.000
B25-B34 Other viral diseases
0.717 0.283 0.000
H47.3 Other disorders of optic disk
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
M79.2 Neuralgia and neuritis, unspecified
0.717 0.283 0.000
M89 Other disorders of bone
0.717 0.283 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.716 0.284 0.000
H31 Other disorders of choroid
0.716 0.284 0.000
H30 Chorioretinal inflammation
0.716 0.284 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.716 0.284 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.715 0.285 0.000
F70-F79 Mental retardation
0.715 0.285 0.000
M79.3 Panniculitis, unspecified
0.715 0.285 0.000
H34 Retinal vascular occlusions
0.715 0.285 0.000
M79.68 Pain in limb (Other)
0.714 0.285 0.000
G00 Bacterial meningitis, not elsewhere classified
0.712 0.288 0.000
Q61 Cystic kidney disease
0.712 0.288 0.000
H33.1 Retinoschisis and retinal cysts
0.712 0.288 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.711 0.288 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.711 0.288 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.711 0.288 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.711 0.288 0.000
F01 Vascular dementia
0.710 0.290 0.000
G54 Nerve root and plexus disorders
0.710 0.290 0.000
B99-B99 Other infectious diseases
0.710 0.290 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.710 0.290 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.710 0.290 0.000
A75-A79 Rickettsioses
0.710 0.290 0.000
A70-A74 Other diseases caused by chlamydiae
0.710 0.290 0.000
A20-A28 Certain zoonotic bacterial diseases
0.710 0.290 0.000
A15-A19 Tuberculosis
0.710 0.290 0.000
G11 Hereditary ataxia
0.709 0.290 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.708 0.292 0.000
H35.5 Hereditary retinal dystrophy
0.708 0.292 0.000
S83.2 Tear of meniscus, current
0.708 0.292 0.000
H43-H45 Disorders of vitreous body and globe
0.707 0.293 0.000
M80.1 Postoophorectomy osteoporosis with pathological fracture
0.707 0.293 0.000
T78.0 Anaphylactic shock due to adverse food reaction
0.707 0.293 0.000
F38 Other mood [affective] disorders
0.706 0.294 0.000
F39 Unspecified mood [affective] disorder
0.706 0.294 0.000
H17 Corneal scars and opacities
0.706 0.294 0.000
S69 Other and unspecified injuries of wrist and hand
0.705 0.295 0.000
M60-M63 Disorders of muscles
0.705 0.295 0.000
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.705 0.295 0.000
H15 Disorders of sclera
0.705 0.295 0.000
F99-F99 Unspecified mental disorder
0.704 0.296 0.000
M79.64 Pain in limb (Hand)
0.704 0.296 0.000
M00-M03 Infectious arthropathies
0.704 0.296 0.000
G93.2 Benign intracranial hypertension
0.701 0.299 0.000
M77.9 Enthesopathy, unspecified
0.701 0.299 0.000
X60-X84 Intentional self-harm
0.700 0.299 0.000
S99 Other and unspecified injuries of ankle and foot
0.700 0.300 0.000
H35.1 Retinopathy of prematurity
0.699 0.301 0.000
B02.2 Zoster with other nervous system involvement
0.699 0.301 0.000
F33.2 Recurrent depressive disorder, current episode severe without psychotic symptoms
0.699 0.301 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.698 0.302 0.000
Q35-Q37 Cleft lip and cleft palate
0.698 0.302 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.698 0.302 0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction
0.694 0.306 0.000
F09 Unspecified organic or symptomatic mental disorder
0.694 0.306 0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances
0.694 0.306 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.693 0.307 0.000
M79.1 Myalgia
0.693 0.307 0.000
F22 Persistent delusional disorders
0.693 0.307 0.000
H20.8 Other iridocyclitis
0.692 0.308 0.000
H10-H13 Disorders of conjunctiva
0.692 0.308 0.000
V20-V29 Motorcycle rider injured in transport accident
0.691 0.308 0.000
V80-V89 Other land transport accidents
0.691 0.309 0.000
H33.4 Traction detachment of retina
0.690 0.310 0.000
H36 Retinal disorders in diseases classified elsewhere
0.690 0.310 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.690 0.310 0.000
M43 Other deforming dorsopathies
0.688 0.312 0.000
V40-V49 Car occupant injured in transport accident
0.688 0.312 0.000
S70 Superficial injury of hip and thigh
0.687 0.313 0.000
D60-D64 Aplastic and other anaemias
0.687 0.313 0.000
H47.0 Disorders of optic nerve, not elsewhere classified
0.687 0.313 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.686 0.314 0.000
G93.0 Cerebral cysts
0.686 0.314 0.000
B08 Other viral infections characterised by skin and mucous membrane lesions, not elsewhere classified
0.686 0.314 0.000
B06 Rubella [German measles]
0.686 0.314 0.000
B05 Measles
0.686 0.314 0.000
B09 Unspecified viral infection characterised by skin and mucous membrane lesions
0.686 0.314 0.000
B04 Monkeypox
0.686 0.314 0.000
B03 Smallpox
0.686 0.314 0.000
S12.10 Fracture of second cervical vertebra (closed)
0.684 0.316 0.000
M79.86 Other specified soft tissue disorders (Lower leg)
0.683 0.317 0.000
F31.8 Other bipolar affective disorders
0.683 0.317 0.000
F31.6 Bipolar affective disorder, current episode mixed
0.683 0.317 0.000
F31.5 Bipolar affective disorder, current episode severe depression with psychotic symptoms
0.683 0.317 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.683 0.317 0.000
H26.4 After-cataract
0.682 0.318 0.000
A07 Other protozoal intestinal diseases
0.682 0.318 0.000
A06 Amoebiasis
0.682 0.318 0.000
A05 Other bacterial foodborne intoxications
0.682 0.318 0.000
A03 Shigellosis
0.682 0.318 0.000
A01 Typhoid and paratyphoid fevers
0.682 0.318 0.000
A00 Cholera
0.682 0.318 0.000
X50-X57 Overexertion, travel and privation
0.682 0.318 0.000
T68 Hypothermia
0.682 0.318 0.000
S60.8 Other superficial injuries of wrist and hand
0.681 0.318 0.000
H02.5 Other disorders affecting eyelid function
0.681 0.319 0.000
M82 Osteoporosis in diseases classified elsewhere
0.680 0.320 0.000
T75 Effects of other external causes
0.680 0.320 0.000
T74 Maltreatment syndromes
0.680 0.320 0.000
T73 Effects of other deprivation
0.680 0.320 0.000
T70 Effects of air pressure and water pressure
0.680 0.320 0.000
T69 Other effects of reduced temperature
0.680 0.320 0.000
T67 Effects of heat and light
0.680 0.320 0.000
T71 Asphyxiation
0.680 0.320 0.000
G08 Intracranial and intraspinal phlebitis and thrombophlebitis
0.679 0.320 0.000
T79-T79 Certain early complications of trauma
0.679 0.321 0.000
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms
0.678 0.321 0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.678 0.322 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.678 0.322 0.000
T42.5 Mixed antiepileptics, not elsewhere classified
0.678 0.322 0.000
T42.3 Barbiturates
0.678 0.322 0.000
T42.2 Succinimides and oxazolidinediones
0.678 0.322 0.000
T42.1 Iminostilbenes
0.678 0.322 0.000
T42.0 Hydantoin derivatives
0.678 0.322 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.678 0.322 0.000
M83 Adult osteomalacia
0.678 0.322 0.000
H21.1 Other vascular disorders of iris and ciliary body
0.678 0.322 0.000
G80 Infantile cerebral palsy
0.677 0.323 0.000
F60 Specific personality disorders
0.676 0.324 0.000
Q87 Other specified congenital malformation syndromes affecting multiple systems
0.676 0.324 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.674 0.325 0.000
H18.5 Hereditary corneal dystrophies
0.674 0.326 0.000
H02.4 Ptosis of eyelid
0.674 0.326 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.674 0.326 0.000
H48 Disorders of optic [2nd] nerve and visual pathways in diseases classified elsewhere
0.674 0.326 0.000
S42 Fracture of shoulder and upper arm
0.673 0.327 0.000
X20-X29 Contact with venomous animals and plants
0.673 0.327 0.000
M45.X9 Ankylosing spondylitis (Site unspecified)
0.672 0.328 0.000
S81.8 Open wound of other parts of lower leg
0.672 0.328 0.000
F05.9 Delirium, unspecified
0.672 0.328 0.000
H05 Disorders of orbit
0.672 0.328 0.000
H28 Cataract and other disorders of lens in diseases classified elsewhere
0.671 0.329 0.000
G40 Epilepsy
0.671 0.329 0.000
B24 Unspecified human immunodeficiency virus [HIV] disease
0.669 0.331 0.000
S92 Fracture of foot, except ankle
0.669 0.331 0.000
S98 Traumatic amputation of ankle and foot
0.669 0.331 0.000
S97 Crushing injury of ankle and foot
0.669 0.331 0.000
S96 Injury of muscle and tendon at ankle and foot level
0.669 0.331 0.000
S95 Injury of blood vessels at ankle and foot level
0.669 0.331 0.000
S94 Injury of nerves at ankle and foot level
0.669 0.331 0.000
H18.4 Corneal degeneration
0.669 0.331 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.668 0.332 0.000
M79.0 Rheumatism, unspecified
0.668 0.332 0.000
S88 Traumatic amputation of lower leg
0.667 0.332 0.000
S87 Crushing injury of lower leg
0.667 0.332 0.000
S85 Injury of blood vessels at lower leg level
0.667 0.332 0.000
S84 Injury of nerves at lower leg level
0.667 0.332 0.000
X10-X19 Contact with heat and hot substances
0.667 0.333 0.000
B49 Unspecified mycosis
0.666 0.334 0.000
H26.2 Complicated cataract
0.665 0.335 0.000
G81 Hemiplegia
0.664 0.336 0.000
F33.1 Recurrent depressive disorder, current episode moderate
0.664 0.336 0.000
M65.91 Synovitis and tenosynovitis, unspecified (Shoulder region)
0.663 0.337 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.662 0.337 0.000
M45.X2 Ankylosing spondylitis (Cervical region)
0.662 0.338 0.000
F06.7 Mild cognitive disorder
0.662 0.338 0.000
T14 Injury of unspecified body region
0.661 0.339 0.000
G06 Intracranial and intraspinal abscess and granuloma
0.661 0.339 0.000
M84.1 Nonunion of fracture [pseudarthrosis]
0.661 0.339 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.659 0.340 0.000
M65.2 Calcific tendinitis
0.659 0.341 0.000
M65.1 Other infective (teno)synovitis
0.659 0.341 0.000
M65.0 Abscess of tendon sheath
0.659 0.341 0.000
M71.34 Other bursal cyst (Hand)
0.658 0.342 0.000
H26.3 Drug-induced cataract
0.658 0.342 0.000
S12.9 Fracture of neck, part unspecified
0.658 0.342 0.000
G13 Systemic atrophies primarily affecting central nervous system in diseases classified elsewhere
0.657 0.343 0.000
G14 Postpolio syndrome
0.657 0.343 0.000
G10 Huntington's disease
0.657 0.343 0.000
S12.7 Multiple fractures of cervical spine
0.656 0.343 0.000
M65.34 Trigger finger-Hand
0.656 0.344 0.000
H21.0 Hyphaema
0.655 0.345 0.000
G82 Paraplegia and tetraplegia
0.655 0.345 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.654 0.345 0.000
S31 Open wound of abdomen, lower back and pelvis
0.654 0.346 0.000
B65-B83 Helminthiases
0.654 0.346 0.000
H26.0 Infantile, juvenile and presenile cataract
0.654 0.346 0.000
A08.4 Viral intestinal infection, unspecified
0.654 0.346 0.000
H47.2 Optic atrophy
0.653 0.347 0.000
G57 Mononeuropathies of lower limb
0.653 0.347 0.000
B35 Dermatophytosis
0.652 0.348 0.000
Q07 Other congenital malformations of nervous system
0.652 0.348 0.000
S91.0 Open wound of ankle
0.652 0.348 0.000
G04 Encephalitis, myelitis and encephalomyelitis
0.652 0.348 0.000
S65 Injury of blood vessels at wrist and hand level
0.652 0.348 0.000
S00-S09 Injuries to the head
0.652 0.348 0.000
T50.9 Other and unspecified drugs, medicaments and biological substances
0.651 0.349 0.000
G90 Disorders of autonomic nervous system
0.651 0.349 0.000
M77.0 Medial epicondylitis
0.651 0.349 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.650 0.350 0.000
S83.6 Sprain and strain of other and unspecified parts of knee
0.650 0.350 0.000
H20.2 Lens-induced iridocyclitis
0.649 0.351 0.000
H20.1 Chronic iridocyclitis
0.649 0.351 0.000
W20-W49 Exposure to inanimate mechanical forces
0.648 0.352 0.000
T18.1 Foreign body in oesophagus
0.648 0.352 0.000
F23.9 Acute and transient psychotic disorder, unspecified
0.647 0.353 0.000
S17 Crushing injury of neck
0.647 0.353 0.000
S15 Injury of blood vessels at neck level
0.647 0.353 0.000
S14 Injury of nerves and spinal cord at neck level
0.647 0.353 0.000
S11 Open wound of neck
0.647 0.353 0.000
S18 Traumatic amputation at neck level
0.647 0.353 0.000
S16 Injury of muscle and tendon at neck level
0.647 0.353 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.647 0.353 0.000
H02.2 Lagophthalmos
0.647 0.353 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.646 0.354 0.000
H18.2 Other corneal oedema
0.644 0.356 0.000
M84.0 Malunion of fracture
0.644 0.356 0.000
Q05 Spina bifida
0.644 0.356 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.643 0.357 0.000
Q43.0 Meckel's diverticulum
0.643 0.357 0.000
T78.9 Adverse effect, unspecified
0.643 0.357 0.000
T78.8 Other adverse effects, not elsewhere classified
0.643 0.357 0.000
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
0.643 0.357 0.000
H65-H75 Diseases of middle ear and mastoid
0.642 0.358 0.000
Q43.3 Congenital malformations of intestinal fixation
0.642 0.358 0.000
M65.4 Radial styloid tenosynovitis [de Quervain]
0.641 0.359 0.000
A02.0 Salmonella gastro-enteritis
0.641 0.359 0.000
M89.9 Disorder of bone, unspecified
0.641 0.359 0.000
A69 Other spirochaetal infections
0.640 0.359 0.000
M40 Kyphosis and lordosis
0.640 0.359 0.000
B37.8 Candidiasis of other sites
0.640 0.360 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.640 0.360 0.000
Y60.8 During other surgical and medical care
0.640 0.360 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.640 0.360 0.000
Q61.3 Polycystic kidney, unspecified
0.638 0.362 0.000
M79.65 Pain in limb (Pelvic region and thigh)
0.638 0.362 0.000
M65.93 Synovitis and tenosynovitis, unspecified (Forearm)
0.637 0.363 0.000
H18.7 Other corneal deformities
0.636 0.364 0.000
H18.3 Changes in corneal membranes
0.636 0.364 0.000
H18.1 Bullous keratopathy
0.636 0.364 0.000
H18.0 Corneal pigmentations and deposits
0.636 0.364 0.000
M65.92 Synovitis and tenosynovitis, unspecified (Upper arm)
0.636 0.364 0.000
M80.10 Postoophorectomy osteoporosis with pathological fracture (Multiple sites)
0.635 0.365 0.000
H16 Keratitis
0.633 0.366 0.000
S42.1 Fracture of scapula
0.632 0.368 0.000
G30.0 Alzheimer's disease with early onset
0.631 0.369 0.000
G54.0 Brachial plexus disorders
0.630 0.370 0.000
G83 Other paralytic syndromes
0.630 0.370 0.000
M79.84 Other specified soft tissue disorders (Hand)
0.630 0.370 0.000
F00.0 Dementia in Alzheimer's disease with early onset
0.629 0.370 0.000
Chapter X Diseases of the respiratory system
0.629 0.371 0.000
B02.8 Zoster with other complications
0.629 0.371 0.000
B02.7 Disseminated zoster
0.629 0.371 0.000
B02.3 Zoster ocular disease
0.629 0.371 0.000
B02.1 Zoster meningitis
0.629 0.371 0.000
B02.0 Zoster encephalitis
0.629 0.371 0.000
Y35-Y36 Legal intervention and operations of war
0.629 0.371 0.000
Y10-Y34 Event of undetermined intent
0.629 0.371 0.000
Y00-Y09 Assault
0.629 0.371 0.000
X85-X99 Assault
0.629 0.371 0.000
X30-X39 Exposure to forces of nature
0.629 0.371 0.000
X00-X09 Exposure to smoke, fire and flames
0.629 0.371 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.629 0.371 0.000
W75-W84 Other accidental threats to breathing
0.629 0.371 0.000
W65-W74 Accidental drowning and submersion
0.629 0.371 0.000
V98-V99 Other and unspecified transport accidents
0.629 0.371 0.000
V95-V97 Air and space transport accidents
0.629 0.371 0.000
V90-V94 Water transport accidents
0.629 0.371 0.000
V70-V79 Bus occupant injured in transport accident
0.629 0.371 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.629 0.371 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.629 0.371 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.629 0.371 0.000
V01-V09 Pedestrian injured in transport accident
0.629 0.371 0.000
T46.1 Calcium-channel blockers
0.629 0.371 0.000
S19 Other and unspecified injuries of neck
0.628 0.372 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.628 0.372 0.000
H02.7 Other degenerative disorders of eyelid and periocular area
0.628 0.372 0.000
S12.20 Fracture of other specified cervical vertebra (closed)
0.628 0.372 0.000
H06.2 Dysthyroid exophthalmos
0.628 0.372 0.000
M24 Other specific joint derangements
0.627 0.373 0.000
G93.1 Anoxic brain damage, not elsewhere classified
0.626 0.374 0.000
Q50-Q56 Congenital malformations of genital organs
0.624 0.375 0.000
Q67 Congenital musculoskeletal deformities of head, face, spine and chest
0.624 0.375 0.000
M79.96 Soft tissue disorder, unspecified (Lower leg)
0.624 0.375 0.000
M79.7 Fibromyalgia
0.624 0.376 0.000
M23 Internal derangement of knee
0.624 0.376 0.000
H47.7 Disorder of visual pathways, unspecified
0.624 0.376 0.000
H47.6 Disorders of visual cortex
0.624 0.376 0.000
H47.5 Disorders of other visual pathways
0.624 0.376 0.000
H47.4 Disorders of optic chiasm
0.624 0.376 0.000
B44 Aspergillosis
0.623 0.376 0.000
S81.0 Open wound of knee
0.623 0.377 0.000
F33.8 Other recurrent depressive disorders
0.623 0.377 0.000
F33.4 Recurrent depressive disorder, currently in remission
0.623 0.377 0.000
F33.0 Recurrent depressive disorder, current episode mild
0.623 0.377 0.000
J30-J39 Other diseases of upper respiratory tract
0.623 0.377 0.000
A09.0 Other and unspecified gastroenteritis and colitis of infectious origin
0.623 0.377 0.000
V10-V19 Pedal cyclist injured in transport accident
0.623 0.377 0.000
B48 Other mycoses, not elsewhere classified
0.623 0.377 0.000
B47 Mycetoma
0.623 0.377 0.000
B46 Zygomycosis
0.623 0.377 0.000
B45 Cryptococcosis
0.623 0.377 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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