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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs11652121
log Bayes Factor = 15.4813
Chromosome 17   position 28,532,332  (GRCh37) Explore rs11652121 on Ensembl!
Variant rs11652121 is part of Cluster X0142

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
I20-I25 Ischaemic heart diseases
1.000 0.000 0.000
Chapter XV Pregnancy, childbirth and the puerperium
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
0.999 0.001 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.994 0.006 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.994 0.006 0.000
I20 Angina pectoris
0.994 0.006 0.000
Chapter X Diseases of the respiratory system
0.993 0.007 0.000
I30-I52 Other forms of heart disease
0.992 0.008 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.990 0.010 0.000
I25.2 Old myocardial infarction
0.987 0.013 0.000
M05-M14 Inflammatory polyarthropathies
0.985 0.015 0.000
O60-O75 Complications of labour and delivery
0.984 0.016 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.983 0.017 0.000
Chapter I Certain infectious and parasitic diseases
0.980 0.020 0.000
I25.1 Atherosclerotic heart disease
0.976 0.024 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.974 0.026 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.972 0.028 0.000
Chapter V Mental and behavioural disorders
0.970 0.030 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.970 0.030 0.000
I60-I69 Cerebrovascular diseases
0.963 0.037 0.000
O72 Postpartum haemorrhage
0.961 0.039 0.000
J20-J22 Other acute lower respiratory infections
0.960 0.040 0.000
M13 Other arthritis
0.958 0.042 0.000
I20.0 Unstable angina
0.957 0.043 0.000
E70-E90 Metabolic disorders
0.953 0.047 0.000
M20-M25 Other joint disorders
0.949 0.051 0.000
O72.1 Other immediate postpartum haemorrhage
0.945 0.055 0.000
R00 Abnormalities of heart beat
0.944 0.056 0.000
M06 Other rheumatoid arthritis
0.943 0.057 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.941 0.059 0.000
I44 Atrioventricular and left bundle-branch block
0.939 0.061 0.000
M13.9 Arthritis, unspecified
0.938 0.062 0.000
Chapter VIII Diseases of the ear and mastoid process
0.928 0.072 0.000
I67 Other cerebrovascular diseases
0.928 0.072 0.000
O34 Maternal care for known or suspected abnormality of pelvic organs
0.925 0.075 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.920 0.080 0.000
O36 Maternal care for other known or suspected foetal problems
0.918 0.082 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.918 0.082 0.000
R00.1 Bradycardia, unspecified
0.915 0.085 0.000
J22 Unspecified acute lower respiratory infection
0.912 0.088 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.912 0.088 0.000
J09-J18 Influenza and pneumonia
0.911 0.089 0.000
B95-B98 Bacterial, viral and other infectious agents
0.911 0.089 0.000
F10 Mental and behavioural disorders due to use of alcohol
0.904 0.096 0.000
I20.9 Angina pectoris, unspecified
0.903 0.097 0.000
M23 Internal derangement of knee
0.903 0.097 0.000
F10.1 Harmful use
0.898 0.102 0.000
M06.9 Rheumatoid arthritis, unspecified
0.895 0.105 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.895 0.105 0.000
R42 Dizziness and giddiness
0.887 0.113 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.882 0.118 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.880 0.120 0.000
O34.2 Maternal care due to uterine scar from previous surgery
0.876 0.124 0.000
I51 Complications and ill-defined descriptions of heart disease
0.874 0.126 0.000
E87.2 Acidosis
0.862 0.138 0.000
I25.5 Ischaemic cardiomyopathy
0.861 0.139 0.000
E00-E07 Disorders of thyroid gland
0.860 0.140 0.000
M13.97 Arthritis, unspecified (Ankle and foot)
0.856 0.144 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.856 0.144 0.000
J18 Pneumonia, organism unspecified
0.853 0.147 0.000
I20.1 Angina pectoris with documented spasm
0.850 0.150 0.000
M13.96 Arthritis, unspecified (Lower leg)
0.850 0.150 0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.849 0.151 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.845 0.155 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.845 0.155 0.000
E87.6 Hypokalaemia
0.841 0.159 0.000
J90-J94 Other diseases of pleura
0.841 0.159 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.838 0.162 0.000
O36.5 Maternal care for poor foetal growth
0.838 0.162 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.835 0.165 0.000
I34 Nonrheumatic mitral valve disorders
0.835 0.165 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.834 0.166 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.833 0.167 0.000
A00-A09 Intestinal infectious diseases
0.831 0.169 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.829 0.170 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.829 0.171 0.000
J20 Acute bronchitis
0.828 0.172 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.828 0.172 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.826 0.174 0.000
J18.9 Pneumonia, unspecified
0.825 0.175 0.000
Chapter XX External causes of morbidity and mortality
0.824 0.176 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.824 0.176 0.000
R03 Abnormal blood-pressure reading, without diagnosis
0.823 0.177 0.000
R01 Cardiac murmurs and other cardiac sounds
0.822 0.177 0.000
M21 Other acquired deformities of limbs
0.821 0.179 0.000
I42 Cardiomyopathy
0.821 0.179 0.000
E87.5 Hyperkalaemia
0.819 0.181 0.000
O80-O84 Delivery
0.814 0.186 0.000
I49 Other cardiac arrhythmias
0.814 0.186 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.813 0.186 0.000
O62 Abnormalities of forces of labour
0.812 0.188 0.000
I67.1 Cerebral aneurysm, nonruptured
0.809 0.191 0.000
M35 Other systemic involvement of connective tissue
0.809 0.191 0.000
I44.0 Atrioventricular block, first degree
0.808 0.192 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.807 0.193 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.806 0.194 0.000
F30-F39 Mood [affective] disorders
0.806 0.194 0.000
I35 Nonrheumatic aortic valve disorders
0.803 0.197 0.000
I67.9 Cerebrovascular disease, unspecified
0.800 0.200 0.000
M13.90 Arthritis, unspecified (Multiple sites)
0.799 0.201 0.000
T66-T78 Other and unspecified effects of external causes
0.798 0.202 0.000
I51.8 Other ill-defined heart diseases
0.798 0.202 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.797 0.203 0.000
J60-J70 Lung diseases due to external agents
0.797 0.203 0.000
H90-H95 Other disorders of ear
0.796 0.204 0.000
O46 Antepartum haemorrhage, not elsewhere classified
0.795 0.205 0.000
I67.8 Other specified cerebrovascular diseases
0.793 0.207 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.793 0.207 0.000
O47 False labour
0.790 0.210 0.000
O48 Prolonged pregnancy
0.789 0.211 0.000
O41 Other disorders of amniotic fluid and membranes
0.787 0.212 0.000
I20.8 Other forms of angina pectoris
0.787 0.212 0.000
J30-J39 Other diseases of upper respiratory tract
0.784 0.216 0.000
O99.0 Anaemia complicating pregnancy, childbirth and the puerperium
0.784 0.216 0.000
R41.0 Disorientation, unspecified
0.782 0.218 0.000
S00-S09 Injuries to the head
0.781 0.219 0.000
M24 Other specific joint derangements
0.781 0.219 0.000
E10-E14 Diabetes mellitus
0.781 0.219 0.000
E03 Other hypothyroidism
0.781 0.219 0.000
S80-S89 Injuries to the knee and lower leg
0.780 0.220 0.000
M06.0 Seronegative rheumatoid arthritis
0.780 0.220 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.779 0.221 0.000
M23.23 Derangement of meniscus due to old tear or injury (Medial collateral ligament or Other and unspecified medial meniscus)
0.779 0.221 0.000
I95 Hypotension
0.778 0.222 0.000
O68 Labour and delivery complicated by foetal stress [distress]
0.777 0.222 0.000
I21 Acute myocardial infarction
0.776 0.224 0.000
E83 Disorders of mineral metabolism
0.774 0.226 0.000
E86 Volume depletion
0.773 0.227 0.000
B35-B49 Mycoses
0.770 0.230 0.000
R00.2 Palpitations
0.769 0.231 0.000
O69 Labour and delivery complicated by umbilical cord complications
0.767 0.233 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.766 0.234 0.000
I38 Endocarditis, valve unspecified
0.764 0.236 0.000
I62 Other nontraumatic intracranial haemorrhage
0.763 0.237 0.000
H80-H83 Diseases of inner ear
0.763 0.237 0.000
J81 Pulmonary oedema
0.763 0.237 0.000
R45 Symptoms and signs involving emotional state
0.762 0.238 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.762 0.238 0.000
O73 Retained placenta and membranes, without haemorrhage
0.761 0.239 0.000
I44.1 Atrioventricular block, second degree
0.760 0.240 0.000
J84 Other interstitial pulmonary diseases
0.760 0.240 0.000
H65-H75 Diseases of middle ear and mastoid
0.760 0.240 0.000
O30 Multiple gestation
0.757 0.243 0.000
I44.2 Atrioventricular block, complete
0.757 0.243 0.000
L97 Ulcer of lower limb, not elsewhere classified
0.755 0.245 0.000
M13.93 Arthritis, unspecified (Forearm)
0.755 0.245 0.000
I44.3 Other and unspecified atrioventricular block
0.753 0.247 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.751 0.249 0.000
R50-R69 General symptoms and signs
0.749 0.251 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.748 0.252 0.000
L60-L75 Disorders of skin appendages
0.748 0.252 0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters
0.746 0.254 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.743 0.257 0.000
F80-F89 Disorders of psychological development
0.742 0.258 0.000
M65-M68 Disorders of synovium and tendon
0.741 0.259 0.000
I61 Intracerebral haemorrhage
0.741 0.259 0.000
I22 Subsequent myocardial infarction
0.739 0.261 0.000
A30-A49 Other bacterial diseases
0.739 0.261 0.000
O36.8 Maternal care for other specified foetal problems
0.739 0.261 0.000
R87 Abnormal findings in specimens from female genital organs
0.739 0.261 0.000
B15-B19 Viral hepatitis
0.737 0.263 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.737 0.263 0.000
I63 Cerebral infarction
0.736 0.264 0.000
R03.0 Elevated blood-pressure reading, without diagnosis of hypertension
0.736 0.264 0.000
R02 Gangrene, not elsewhere classified
0.735 0.265 0.000
M40-M43 Deforming dorsopathies
0.734 0.265 0.000
M23.8 Other internal derangements of knee
0.734 0.266 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.734 0.266 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.734 0.266 0.000
J20.9 Acute bronchitis, unspecified
0.733 0.267 0.000
O32 Maternal care for known or suspected malpresentation of foetus
0.733 0.267 0.000
E50-E64 Other nutritional deficiencies
0.730 0.270 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.730 0.270 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.729 0.271 0.000
E20-E35 Disorders of other endocrine glands
0.728 0.272 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.725 0.274 0.000
A04 Other bacterial intestinal infections
0.725 0.275 0.000
I34.0 Mitral (valve) insufficiency
0.725 0.275 0.000
I05-I09 Chronic rheumatic heart diseases
0.724 0.275 0.000
M05 Seropositive rheumatoid arthritis
0.724 0.276 0.000
E03.9 Hypothyroidism, unspecified
0.724 0.276 0.000
I95.9 Hypotension, unspecified
0.723 0.277 0.000
J91 Pleural effusion in conditions classified elsewhere
0.723 0.277 0.000
R26 Abnormalities of gait and mobility
0.721 0.279 0.000
B25-B34 Other viral diseases
0.721 0.279 0.000
R04 Haemorrhage from respiratory passages
0.720 0.280 0.000
M80-M85 Disorders of bone density and structure
0.719 0.281 0.000
Chapter VI Diseases of the nervous system
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I23 Certain current complications following acute myocardial infarction
0.717 0.283 0.000
O85-O92 Complications predominantly related to the puerperium
0.717 0.283 0.000
I25.6 Silent myocardial ischaemia
0.716 0.284 0.000
I25.4 Coronary artery aneurysm
0.716 0.284 0.000
I25.3 Aneurysm of heart
0.716 0.284 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.716 0.284 0.000
E87.7 Fluid overload
0.716 0.284 0.000
M22 Disorders of patella
0.716 0.284 0.000
I42.0 Dilated cardiomyopathy
0.716 0.284 0.000
T90 Sequelae of injuries of head
0.716 0.284 0.000
R40 Somnolence, stupor and coma
0.715 0.285 0.000
L91 Hypertrophic disorders of skin
0.714 0.286 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.713 0.287 0.000
O45 Premature separation of placenta [abruptio placentae]
0.713 0.287 0.000
O44 Placenta praevia
0.713 0.287 0.000
O43 Placental disorders
0.713 0.287 0.000
O35 Maternal care for known or suspected foetal abnormality and damage
0.713 0.287 0.000
O33 Maternal care for known or suspected disproportion
0.713 0.287 0.000
O31 Complications specific to multiple gestation
0.713 0.287 0.000
O40 Polyhydramnios
0.713 0.287 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.712 0.287 0.000
W00-W19 Falls
0.711 0.289 0.000
I52 Other heart disorders in diseases classified elsewhere
0.711 0.289 0.000
I48 Atrial fibrillation and flutter
0.711 0.289 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.711 0.289 0.000
I41 Myocarditis in diseases classified elsewhere
0.711 0.289 0.000
I40 Acute myocarditis
0.711 0.289 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.711 0.289 0.000
I37 Pulmonary valve disorders
0.711 0.289 0.000
I36 Nonrheumatic tricuspid valve disorders
0.711 0.289 0.000
I33 Acute and subacute endocarditis
0.711 0.289 0.000
I32 Pericarditis in diseases classified elsewhere
0.711 0.289 0.000
I30 Acute pericarditis
0.711 0.289 0.000
B95.7 Other staphylococcus as the cause of diseases classified to other chapters
0.710 0.290 0.000
M91-M94 Chondropathies
0.710 0.290 0.000
M86-M90 Other osteopathies
0.710 0.290 0.000
M60-M63 Disorders of muscles
0.710 0.290 0.000
M00-M03 Infectious arthropathies
0.710 0.290 0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.709 0.291 0.000
S20-S29 Injuries to the thorax
0.707 0.293 0.000
M14 Arthropathies in other diseases classified elsewhere
0.706 0.294 0.000
M12 Other specific arthropathies
0.706 0.294 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.706 0.294 0.000
M08 Juvenile arthritis
0.706 0.294 0.000
M07 Psoriatic and enteropathic arthropathies
0.706 0.294 0.000
O74 Complications of anaesthesia during labour and delivery
0.705 0.294 0.000
O71 Other obstetric trauma
0.705 0.294 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.705 0.294 0.000
O66 Other obstructed labour
0.705 0.294 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.705 0.294 0.000
O61 Failed induction of labour
0.705 0.294 0.000
O60 Preterm delivery
0.705 0.294 0.000
I24 Other acute ischaemic heart diseases
0.705 0.295 0.000
R47-R49 Symptoms and signs involving speech and voice
0.705 0.295 0.000
E40-E46 Malnutrition
0.705 0.295 0.000
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness
0.704 0.296 0.000
I44.7 Left bundle-branch block, unspecified
0.704 0.296 0.000
S70-S79 Injuries to the hip and thigh
0.703 0.297 0.000
M21.1 Varus deformity, not elsewhere classified
0.703 0.297 0.000
O99.6 Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
0.702 0.297 0.000
B99-B99 Other infectious diseases
0.702 0.297 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.702 0.297 0.000
B65-B83 Helminthiases
0.702 0.297 0.000
B50-B64 Protozoal diseases
0.702 0.297 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.702 0.297 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.702 0.297 0.000
A80-A89 Viral infections of the central nervous system
0.702 0.297 0.000
A75-A79 Rickettsioses
0.702 0.297 0.000
A70-A74 Other diseases caused by chlamydiae
0.702 0.297 0.000
A65-A69 Other spirochaetal diseases
0.702 0.297 0.000
A20-A28 Certain zoonotic bacterial diseases
0.702 0.297 0.000
A15-A19 Tuberculosis
0.702 0.297 0.000
O42 Premature rupture of membranes
0.702 0.298 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.701 0.299 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.700 0.299 0.000
D68 Other coagulation defects
0.700 0.300 0.000
M13.99 Arthritis, unspecified (Site unspecified)
0.700 0.300 0.000
R05 Cough
0.699 0.301 0.000
I67.2 Cerebral atherosclerosis
0.699 0.301 0.000
R21 Rash and other nonspecific skin eruption
0.699 0.301 0.000
R46 Symptoms and signs involving appearance and behaviour
0.699 0.301 0.000
R43 Disturbances of smell and taste
0.699 0.301 0.000
Chapter XXII Codes for special purposes
0.697 0.303 0.000
J36 Peritonsillar abscess
0.697 0.303 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.697 0.303 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.696 0.304 0.000
S90-S99 Injuries to the ankle and foot
0.696 0.304 0.000
M11 Other crystal arthropathies
0.695 0.305 0.000
F99-F99 Unspecified mental disorder
0.695 0.305 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.695 0.305 0.000
F70-F79 Mental retardation
0.695 0.305 0.000
F60-F69 Disorders of adult personality and behaviour
0.695 0.305 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.695 0.305 0.000
T79-T79 Certain early complications of trauma
0.695 0.305 0.000
T33-T35 Frostbite
0.695 0.305 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.695 0.305 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.695 0.305 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.695 0.305 0.000
T00-T07 Injuries involving multiple body regions
0.695 0.305 0.000
S10-S19 Injuries to the neck
0.695 0.305 0.000
M45-M49 Spondylopathies
0.695 0.305 0.000
M13.91 Arthritis, unspecified (Shoulder region)
0.694 0.306 0.000
R06 Abnormalities of breathing
0.693 0.307 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.692 0.308 0.000
M23.3 Other meniscus derangements
0.692 0.308 0.000
H91 Other hearing loss
0.692 0.308 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.691 0.309 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.691 0.309 0.000
I50 Heart failure
0.689 0.311 0.000
O72.3 Postpartum coagulation defects
0.689 0.311 0.000
O72.2 Delayed and secondary postpartum haemorrhage
0.689 0.311 0.000
O72.0 Third-stage haemorrhage
0.689 0.311 0.000
O62.3 Precipitate labour
0.689 0.311 0.000
J21 Acute bronchiolitis
0.689 0.311 0.000
O16 Unspecified maternal hypertension
0.688 0.312 0.000
M13.8 Other specified arthritis
0.687 0.313 0.000
M13.1 Monoarthritis, not elsewhere classified
0.687 0.313 0.000
M13.0 Polyarthritis, unspecified
0.687 0.313 0.000
E88 Other metabolic disorders
0.683 0.316 0.000
E85 Amyloidosis
0.683 0.316 0.000
E84 Cystic fibrosis
0.683 0.316 0.000
E79 Disorders of purine and pyrimidine metabolism
0.683 0.316 0.000
E77 Disorders of glycoprotein metabolism
0.683 0.316 0.000
E76 Disorders of glycosaminoglycan metabolism
0.683 0.316 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.683 0.316 0.000
E74 Other disorders of carbohydrate metabolism
0.683 0.316 0.000
E73 Lactose intolerance
0.683 0.316 0.000
E72 Other disorders of amino-acid metabolism
0.683 0.316 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.683 0.316 0.000
E70 Disorders of aromatic amino-acid metabolism
0.683 0.316 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.683 0.316 0.000
O26 Maternal care for other conditions predominantly related to pregnancy
0.681 0.318 0.000
L20-L30 Dermatitis and eczema
0.681 0.318 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.681 0.319 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.681 0.319 0.000
M34 Systemic sclerosis
0.681 0.319 0.000
M33 Dermatopolymyositis
0.681 0.319 0.000
M32 Systemic lupus erythematosus
0.681 0.319 0.000
M30 Polyarteritis nodosa and related conditions
0.681 0.319 0.000
I31 Other diseases of pericardium
0.680 0.319 0.000
R01.0 Benign and innocent cardiac murmurs
0.680 0.320 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.679 0.321 0.000
D55-D59 Haemolytic anaemias
0.679 0.321 0.000
I98 Other disorders of circulatory system in diseases classified elsewhere
0.678 0.321 0.000
M35.0 Sicca syndrome [Sjogren]
0.679 0.321 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.678 0.322 0.000
R00.8 Other and unspecified abnormalities of heart beat
0.677 0.323 0.000
M06.8 Other specified rheumatoid arthritis
0.676 0.323 0.000
M06.4 Inflammatory polyarthropathy
0.676 0.323 0.000
M06.3 Rheumatoid nodule
0.676 0.323 0.000
M06.2 Rheumatoid bursitis
0.676 0.323 0.000
M06.1 Adult-onset Still's disease
0.676 0.323 0.000
O00-O08 Pregnancy with abortive outcome
0.676 0.324 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.675 0.325 0.000
E87.4 Mixed disorder of acid-base balance
0.675 0.325 0.000
E87.3 Alkalosis
0.675 0.325 0.000
E87.0 Hyperosmolality and hypernatraemia
0.675 0.325 0.000
T78 Adverse effects, not elsewhere classified
0.675 0.325 0.000
M10 Gout
0.674 0.326 0.000
F10.3 Withdrawal state
0.674 0.326 0.000
M13.98 Arthritis, unspecified (Other)
0.674 0.326 0.000
O82 Single delivery by Caesarean section
0.674 0.326 0.000
I44.6 Other and unspecified fascicular block
0.673 0.326 0.000
I44.5 Left posterior fascicular block
0.673 0.326 0.000
I44.4 Left anterior fascicular block
0.673 0.326 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.673 0.327 0.000
M13.95 Arthritis, unspecified (Pelvic region and thigh)
0.673 0.327 0.000
M13.92 Arthritis, unspecified (Upper arm)
0.673 0.327 0.000
O63 Long labour
0.672 0.328 0.000
H60-H62 Diseases of external ear
0.672 0.328 0.000
R44.3 Hallucinations, unspecified
0.671 0.329 0.000
M23.20 Derangement of meniscus due to old tear or injury (Multiple sites)
0.670 0.330 0.000
R00.0 Tachycardia, unspecified
0.667 0.332 0.000
S40-S49 Injuries to the shoulder and upper arm
0.666 0.334 0.000
I67.7 Cerebral arteritis, not elsewhere classified
0.665 0.335 0.000
I67.6 Nonpyogenic thrombosis of intracranial venous system
0.665 0.335 0.000
I67.5 Moyamoya disease
0.665 0.335 0.000
I67.4 Hypertensive encephalopathy
0.665 0.335 0.000
I67.3 Progressive vascular leukoencephalopathy
0.665 0.335 0.000
I67.0 Dissection of cerebral arteries, nonruptured
0.665 0.335 0.000
O34.9 Maternal care for abnormality of pelvic organ, unspecified
0.663 0.336 0.000
O34.8 Maternal care for other abnormalities of pelvic organs
0.663 0.336 0.000
O34.7 Maternal care for abnormality of vulva and perineum
0.663 0.336 0.000
O34.6 Maternal care for abnormality of vagina
0.663 0.336 0.000
O34.5 Maternal care for other abnormalities of gravid uterus
0.663 0.336 0.000
O34.4 Maternal care for other abnormalities of cervix
0.663 0.336 0.000
O34.3 Maternal care for cervical incompetence
0.663 0.336 0.000
O34.1 Maternal care for tumour of corpus uteri
0.663 0.336 0.000
O34.0 Maternal care for congenital malformation of uterus
0.663 0.336 0.000
M23.21 Derangement of meniscus due to old tear or injury (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.663 0.337 0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.662 0.338 0.000
F41 Other anxiety disorders
0.662 0.338 0.000
L89 Decubitus ulcer
0.662 0.338 0.000
J84.1 Other interstitial pulmonary diseases with fibrosis
0.662 0.338 0.000
B96.2 Escherichia coli [E. coli] as the cause of diseases classified to other chapters
0.662 0.338 0.000
O36.0 Maternal care for rhesus isoimmunisation
0.660 0.340 0.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.660 0.340 0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances
0.660 0.340 0.000
F18 Mental and behavioural disorders due to use of volatile solvents
0.660 0.340 0.000
F16 Mental and behavioural disorders due to use of hallucinogens
0.660 0.340 0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine
0.660 0.340 0.000
F14 Mental and behavioural disorders due to use of cocaine
0.660 0.340 0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics
0.660 0.340 0.000
F12 Mental and behavioural disorders due to use of cannabinoids
0.660 0.340 0.000
F11 Mental and behavioural disorders due to use of opioids
0.660 0.340 0.000
I25.9 Chronic ischaemic heart disease, unspecified
0.660 0.340 0.000
E07 Other disorders of thyroid
0.659 0.341 0.000
E04 Other non-toxic goitre
0.659 0.341 0.000
S60-S69 Injuries to the wrist and hand
0.658 0.341 0.000
O36.9 Maternal care for foetal problem, unspecified
0.658 0.342 0.000
O36.7 Maternal care for viable foetus in abdominal pregnancy
0.658 0.342 0.000
O36.6 Maternal care for excessive foetal growth
0.658 0.342 0.000
O36.4 Maternal care for intra-uterine death
0.658 0.342 0.000
O36.3 Maternal care for signs of foetal hypoxia
0.658 0.342 0.000
O36.2 Maternal care for hydrops foetalis
0.658 0.342 0.000
O36.1 Maternal care for other isoimmunisation
0.658 0.342 0.000
L10-L14 Bullous disorders
0.658 0.342 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.657 0.343 0.000
J69 Pneumonitis due to solids and liquids
0.657 0.343 0.000
M23.4 Loose body in knee
0.656 0.343 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.656 0.343 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.656 0.344 0.000
B96.3 Haemophilus influenzae [H. influenzae] as the cause of diseases classified to other chapters
0.655 0.345 0.000
L60 Nail disorders
0.655 0.345 0.000
O98 Maternal infectious and parasitic diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.654 0.346 0.000
O97 Death from sequelae of direct obstetric causes
0.654 0.346 0.000
O96 Death from any obstetric cause occurring more than 42 days but less than one year after delivery
0.654 0.346 0.000
O95 Obstetric death of unspecified cause
0.654 0.346 0.000
O94 Sequelae of complication of pregnancy, childbirth and the puerperium
0.654 0.346 0.000
J17 Pneumonia in diseases classified elsewhere
0.653 0.346 0.000
J16 Pneumonia due to other infectious organisms, not elsewhere classified
0.653 0.346 0.000
J15 Bacterial pneumonia, not elsewhere classified
0.653 0.346 0.000
J12 Viral pneumonia, not elsewhere classified
0.653 0.346 0.000
J11 Influenza, virus not identified
0.653 0.346 0.000
J10 Influenza due to identified influenza virus
0.653 0.346 0.000
J14 Pneumonia due to Haemophilus influenzae
0.653 0.346 0.000
J13 Pneumonia due to Streptococcus pneumoniae
0.653 0.346 0.000
J09 Influenza due to certain identified influenza virus
0.653 0.346 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.653 0.347 0.000
I49.8 Other specified cardiac arrhythmias
0.653 0.347 0.000
I47 Paroxysmal tachycardia
0.653 0.347 0.000
O46.9 Antepartum haemorrhage, unspecified
0.652 0.348 0.000
R55 Syncope and collapse
0.652 0.348 0.000
L81 Other disorders of pigmentation
0.651 0.349 0.000
I49.1 Atrial premature depolarisation
0.651 0.349 0.000
L84 Corns and callosities
0.650 0.350 0.000
H65 Nonsuppurative otitis media
0.650 0.350 0.000
R73 Elevated blood glucose level
0.649 0.351 0.000
I46 Cardiac arrest
0.649 0.351 0.000
R25 Abnormal involuntary movements
0.648 0.352 0.000
T81 Complications of procedures, not elsewhere classified
0.648 0.352 0.000
F10.9 Unspecified mental and behavioural disorder
0.648 0.352 0.000
F10.8 Other mental and behavioural disorders
0.648 0.352 0.000
F10.7 Residual and late-onset psychotic disorder
0.648 0.352 0.000
F10.6 Amnesic syndrome
0.648 0.352 0.000
F10.5 Psychotic disorder
0.648 0.352 0.000
F10.4 Withdrawal state with delirium
0.648 0.352 0.000
R01.1 Cardiac murmur, unspecified
0.648 0.352 0.000
J92 Pleural plaque
0.648 0.352 0.000
F31 Bipolar affective disorder
0.648 0.352 0.000
M23.9 Internal derangement of knee, unspecified
0.647 0.353 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.647 0.353 0.000
M23.5 Chronic instability of knee
0.647 0.353 0.000
M23.1 Discoid meniscus (congenital)
0.647 0.353 0.000
M23.0 Cystic meniscus
0.647 0.353 0.000
E83.3 Disorders of phosphorus metabolism
0.646 0.354 0.000
M23.26 Derangement of meniscus due to old tear or injury (Other and unspecified lateral meniscus)
0.646 0.354 0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.645 0.355 0.000
Chapter XIV Diseases of the genitourinary system
0.644 0.356 0.000
T93 Sequelae of injuries of lower limb
0.644 0.356 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.644 0.356 0.000
A04.7 Enterocolitis due to Clostridium difficile
0.643 0.357 0.000
R22 Localised swelling, mass and lump of skin and subcutaneous tissue
0.643 0.357 0.000
B96.1 Klebsiella pneumoniae [K. pneumoniae] as the cause of diseases classified to other chapters
0.642 0.357 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.642 0.358 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.642 0.358 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.642 0.358 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.642 0.358 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.642 0.358 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.642 0.358 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.642 0.358 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.642 0.358 0.000
J82 Pulmonary eosinophilia, not elsewhere classified
0.642 0.358 0.000
J80 Adult respiratory distress syndrome
0.642 0.358 0.000
N17-N19 Renal failure
0.641 0.359 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.640 0.359 0.000
B95.8 Unspecified staphylococcus as the cause of diseases classified to other chapters
0.640 0.360 0.000
M23.24 Derangement of meniscus due to old tear or injury (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.640 0.360 0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria
0.639 0.360 0.000
O41.0 Oligohydramnios
0.639 0.360 0.000
M31 Other necrotising vasculopathies
0.639 0.361 0.000
O47.9 False labour, unspecified
0.639 0.361 0.000
R41.3 Other amnesia
0.637 0.363 0.000
D50-D53 Nutritional anaemias
0.637 0.363 0.000
I51.7 Cardiomegaly
0.636 0.364 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.636 0.364 0.000
D68.9 Coagulation defect, unspecified
0.635 0.365 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.634 0.366 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.634 0.366 0.000
R06.4 Hyperventilation
0.634 0.366 0.000
M21.0 Valgus deformity, not elsewhere classified
0.634 0.366 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.633 0.367 0.000
L90 Atrophic disorders of skin
0.633 0.367 0.000
R26.8 Other and unspecified abnormalities of gait and mobility
0.633 0.367 0.000
H81 Disorders of vestibular function
0.633 0.367 0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.632 0.368 0.000
I99 Other and unspecified disorders of circulatory system
0.632 0.368 0.000
M35.3 Polymyalgia rheumatica
0.631 0.369 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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