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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs116577322
log Bayes Factor = 9.37016
Chromosome 5   position 132,850,336  (GRCh37) Explore rs116577322 on Ensembl!
Variant rs116577322 is part of Cluster X0053

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter XX External causes of morbidity and mortality
0.999 0.001 0.000
R50-R69 General symptoms and signs
0.997 0.003 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.997 0.003 0.000
W00-W19 Falls
0.995 0.005 0.000
R00 Abnormalities of heart beat
0.993 0.007 0.000
S00-S09 Injuries to the head
0.992 0.008 0.000
R00.2 Palpitations
0.992 0.008 0.000
Chapter IX Diseases of the circulatory system
0.991 0.009 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.989 0.011 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.985 0.015 0.000
Chapter II Neoplasms
0.984 0.016 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.982 0.018 0.000
W19 Unspecified fall
0.982 0.018 0.000
R55 Syncope and collapse
0.979 0.021 0.000
R20 Disturbances of skin sensation
0.970 0.030 0.000
C79 Secondary malignant neoplasm of other sites
0.966 0.034 0.000
S02 Fracture of skull and facial bones
0.965 0.035 0.000
I60-I69 Cerebrovascular diseases
0.965 0.035 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.962 0.038 0.000
R52 Pain, not elsewhere classified
0.960 0.040 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.956 0.044 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.954 0.046 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.950 0.050 0.000
C78.7 Secondary malignant neoplasm of liver
0.945 0.055 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.945 0.055 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.943 0.057 0.000
W19.4 Street and highway
0.943 0.057 0.000
S01 Open wound of head
0.934 0.066 0.000
R20.2 Paraesthesia of skin
0.928 0.072 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.927 0.073 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.925 0.075 0.000
R52.1 Chronic intractable pain
0.923 0.077 0.000
I69 Sequelae of cerebrovascular disease
0.922 0.078 0.000
C78.5 Secondary malignant neoplasm of large intestine and rectum
0.920 0.080 0.000
R56 Convulsions, not elsewhere classified
0.919 0.081 0.000
S02.2 Fracture of nasal bones
0.917 0.083 0.000
R42 Dizziness and giddiness
0.916 0.084 0.000
O60-O75 Complications of labour and delivery
0.912 0.088 0.000
I73 Other peripheral vascular diseases
0.910 0.090 0.000
W19.2 School, other institution and public administrative area
0.908 0.092 0.000
R03 Abnormal blood-pressure reading, without diagnosis
0.906 0.094 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.897 0.103 0.000
S40-S49 Injuries to the shoulder and upper arm
0.896 0.104 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.896 0.104 0.000
I73.9 Peripheral vascular disease, unspecified
0.894 0.106 0.000
S01.8 Open wound of other parts of head
0.884 0.116 0.000
R20.8 Other and unspecified disturbances of skin sensation
0.884 0.116 0.000
S02.20 Fracture of nasal bones (closed)
0.883 0.117 0.000
W06 Fall involving bed
0.881 0.119 0.000
R60 Oedema, not elsewhere classified
0.880 0.120 0.000
R06 Abnormalities of breathing
0.880 0.120 0.000
Q60-Q64 Congenital malformations of the urinary system
0.876 0.124 0.000
R03.1 Nonspecific low blood-pressure reading
0.872 0.128 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.872 0.128 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.871 0.129 0.000
I95 Hypotension
0.865 0.135 0.000
R50 Fever of unknown origin
0.865 0.135 0.000
T66-T78 Other and unspecified effects of external causes
0.862 0.138 0.000
R56.8 Other and unspecified convulsions
0.862 0.138 0.000
C79.8 Secondary malignant neoplasm of other specified sites
0.859 0.141 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.859 0.141 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.854 0.146 0.000
R26 Abnormalities of gait and mobility
0.849 0.151 0.000
C51-C58 Malignant neoplasms of female genital organs
0.848 0.152 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.847 0.153 0.000
C79.5 Secondary malignant neoplasm of bone and bone marrow
0.847 0.153 0.000
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum
0.844 0.156 0.000
R21 Rash and other nonspecific skin eruption
0.843 0.157 0.000
C91 Lymphoid leukaemia
0.842 0.158 0.000
C78.0 Secondary malignant neoplasm of lung
0.839 0.161 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.835 0.165 0.000
V40-V49 Car occupant injured in transport accident
0.833 0.167 0.000
I60 Subarachnoid haemorrhage
0.826 0.174 0.000
I62 Other nontraumatic intracranial haemorrhage
0.826 0.174 0.000
C79.7 Secondary malignant neoplasm of adrenal gland
0.823 0.177 0.000
Q61 Cystic kidney disease
0.822 0.178 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.821 0.179 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.819 0.181 0.000
W19.1 Residential institution
0.817 0.183 0.000
X60-X84 Intentional self-harm
0.816 0.184 0.000
S60-S69 Injuries to the wrist and hand
0.816 0.184 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.815 0.185 0.000
S09 Other and unspecified injuries of head
0.808 0.192 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.807 0.193 0.000
I98 Other disorders of circulatory system in diseases classified elsewhere
0.805 0.195 0.000
R47-R49 Symptoms and signs involving speech and voice
0.802 0.198 0.000
I05-I09 Chronic rheumatic heart diseases
0.802 0.198 0.000
R68 Other general symptoms and signs
0.801 0.199 0.000
R23 Other skin changes
0.800 0.200 0.000
S20-S29 Injuries to the thorax
0.798 0.202 0.000
I99 Other and unspecified disorders of circulatory system
0.798 0.202 0.000
R60.0 Localised oedema
0.797 0.203 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.795 0.205 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.792 0.208 0.000
T79-T79 Certain early complications of trauma
0.789 0.211 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.783 0.217 0.000
C78.4 Secondary malignant neoplasm of small intestine
0.783 0.217 0.000
C79.2 Secondary malignant neoplasm of skin
0.777 0.223 0.000
R26.8 Other and unspecified abnormalities of gait and mobility
0.777 0.223 0.000
C90 Multiple myeloma and malignant plasma cell neoplasms
0.777 0.223 0.000
O00-O08 Pregnancy with abortive outcome
0.776 0.224 0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.775 0.225 0.000
S06 Intracranial injury
0.772 0.228 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.770 0.230 0.000
I61 Intracerebral haemorrhage
0.770 0.230 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.769 0.231 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.768 0.232 0.000
O63 Long labour
0.768 0.232 0.000
R52.2 Other chronic pain
0.767 0.233 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.767 0.233 0.000
R29.6 Tendency to fall, not elsewhere classified
0.767 0.233 0.000
R87 Abnormal findings in specimens from female genital organs
0.765 0.235 0.000
W07 Fall involving chair
0.765 0.235 0.000
W08 Fall involving other furniture
0.764 0.236 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.763 0.237 0.000
C79.6 Secondary malignant neoplasm of ovary
0.762 0.238 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.762 0.238 0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.755 0.245 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.754 0.246 0.000
R40 Somnolence, stupor and coma
0.754 0.246 0.000
R85 Abnormal findings in specimens from digestive organs and abdominal cavity
0.754 0.246 0.000
W06.0 Home
0.754 0.246 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.754 0.246 0.000
V10-V19 Pedal cyclist injured in transport accident
0.753 0.247 0.000
S10-S19 Injuries to the neck
0.753 0.247 0.000
I72 Other aneurysm
0.752 0.248 0.000
S90-S99 Injuries to the ankle and foot
0.752 0.248 0.000
X50-X57 Overexertion, travel and privation
0.752 0.248 0.000
S01.1 Open wound of eyelid and periocular area
0.752 0.248 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.751 0.249 0.000
C91.1 Chronic lymphocytic leukaemia
0.750 0.250 0.000
S02.6 Fracture of mandible
0.748 0.252 0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage
0.748 0.252 0.000
W20-W49 Exposure to inanimate mechanical forces
0.748 0.252 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.747 0.253 0.000
I95.2 Hypotension due to drugs
0.746 0.254 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.746 0.254 0.000
Y86 Sequelae of other accidents
0.745 0.255 0.000
W50-W64 Exposure to animate mechanical forces
0.744 0.255 0.000
O62 Abnormalities of forces of labour
0.744 0.256 0.000
W18 Other fall on same level
0.743 0.256 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.744 0.256 0.000
S50-S59 Injuries to the elbow and forearm
0.742 0.258 0.000
X20-X29 Contact with venomous animals and plants
0.742 0.258 0.000
R09.8 Other specified symptoms and signs involving the circulatory and respiratory systems
0.741 0.259 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.741 0.259 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.740 0.260 0.000
O02 Other abnormal products of conception
0.740 0.260 0.000
O68 Labour and delivery complicated by foetal stress [distress]
0.739 0.261 0.000
V80-V89 Other land transport accidents
0.739 0.261 0.000
C78.2 Secondary malignant neoplasm of pleura
0.738 0.262 0.000
Y44 Agents primarily affecting blood constituents
0.737 0.263 0.000
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
0.736 0.264 0.000
S02.1 Fracture of base of skull
0.735 0.265 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.734 0.266 0.000
S01.0 Open wound of scalp
0.734 0.266 0.000
I60.2 Subarachnoid haemorrhage from anterior communicating artery
0.734 0.266 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.734 0.266 0.000
O61 Failed induction of labour
0.733 0.266 0.000
S42 Fracture of shoulder and upper arm
0.733 0.267 0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.733 0.267 0.000
S01.9 Open wound of head, part unspecified
0.733 0.267 0.000
I95.1 Orthostatic hypotension
0.733 0.267 0.000
S02.0 Fracture of vault of skull
0.732 0.268 0.000
R02 Gangrene, not elsewhere classified
0.732 0.268 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.731 0.269 0.000
I30-I52 Other forms of heart disease
0.731 0.269 0.000
I69.3 Sequelae of cerebral infarction
0.730 0.270 0.000
S05 Injury of eye and orbit
0.729 0.271 0.000
T68 Hypothermia
0.729 0.271 0.000
S02.3 Fracture of orbital floor
0.729 0.271 0.000
R46 Symptoms and signs involving appearance and behaviour
0.729 0.271 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.729 0.271 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.727 0.273 0.000
Q61.3 Polycystic kidney, unspecified
0.727 0.273 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.727 0.273 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.725 0.275 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.725 0.275 0.000
S02.4 Fracture of malar and maxillary bones
0.724 0.276 0.000
I69.0 Sequelae of subarachnoid haemorrhage
0.723 0.277 0.000
I69.1 Sequelae of intracerebral haemorrhage
0.722 0.277 0.000
R50.0 Fever with chills
0.722 0.278 0.000
I27 Other pulmonary heart diseases
0.722 0.278 0.000
W06.9 Unspecified place
0.721 0.279 0.000
W10 Fall on and from stairs and steps
0.721 0.279 0.000
S46 Injury of muscle and tendon at shoulder and upper arm level
0.720 0.280 0.000
W13 Fall from, out of or through building or structure
0.719 0.281 0.000
S31 Open wound of abdomen, lower back and pelvis
0.719 0.281 0.000
I73.0 Raynaud's syndrome
0.718 0.282 0.000
C56 Malignant neoplasm of ovary
0.717 0.283 0.000
S41 Open wound of shoulder and upper arm
0.717 0.283 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
Y35-Y36 Legal intervention and operations of war
0.716 0.283 0.000
Y10-Y34 Event of undetermined intent
0.716 0.283 0.000
Y00-Y09 Assault
0.716 0.283 0.000
X85-X99 Assault
0.716 0.283 0.000
X30-X39 Exposure to forces of nature
0.716 0.283 0.000
X10-X19 Contact with heat and hot substances
0.716 0.283 0.000
X00-X09 Exposure to smoke, fire and flames
0.716 0.283 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.716 0.283 0.000
W75-W84 Other accidental threats to breathing
0.716 0.283 0.000
W65-W74 Accidental drowning and submersion
0.716 0.283 0.000
V98-V99 Other and unspecified transport accidents
0.716 0.283 0.000
V95-V97 Air and space transport accidents
0.716 0.283 0.000
V90-V94 Water transport accidents
0.716 0.283 0.000
V70-V79 Bus occupant injured in transport accident
0.716 0.283 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.716 0.283 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.716 0.283 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.716 0.283 0.000
V01-V09 Pedestrian injured in transport accident
0.716 0.283 0.000
R06.4 Hyperventilation
0.715 0.285 0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]
0.715 0.285 0.000
R62 Lack of expected normal physiological development
0.715 0.285 0.000
R64 Cachexia
0.715 0.285 0.000
R06.8 Other and unspecified abnormalities of breathing
0.715 0.285 0.000
T40.2 Other opioids
0.714 0.286 0.000
O02.1 Missed abortion
0.714 0.286 0.000
R49 Voice disturbances
0.714 0.286 0.000
W17 Other fall from one level to another
0.713 0.287 0.000
W16 Diving or jumping into water causing injury other than drowning or submersion
0.713 0.287 0.000
W15 Fall from cliff
0.713 0.287 0.000
W14 Fall from tree
0.713 0.287 0.000
W12 Fall on and from scaffolding
0.713 0.287 0.000
W11 Fall on and from ladder
0.713 0.287 0.000
W09 Fall involving playground equipment
0.713 0.287 0.000
W05 Fall involving wheelchair
0.713 0.287 0.000
W04 Fall while being carried or supported by other persons
0.713 0.287 0.000
W03 Other fall on same level due to collision with, or pushing by, another person
0.713 0.287 0.000
W01 Fall on same level from slipping, tripping and stumbling
0.713 0.287 0.000
W00 Fall on same level involving ice and snow
0.713 0.287 0.000
I34 Nonrheumatic mitral valve disorders
0.713 0.287 0.000
S08 Traumatic amputation of part of head
0.711 0.288 0.000
S07 Crushing injury of head
0.711 0.288 0.000
S04 Injury of cranial nerves
0.711 0.288 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.711 0.288 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.711 0.289 0.000
I00-I02 Acute rheumatic fever
0.710 0.290 0.000
C92 Myeloid leukaemia
0.710 0.290 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.709 0.291 0.000
R25 Abnormal involuntary movements
0.707 0.293 0.000
Y43 Primarily systemic agents
0.707 0.293 0.000
C80 Malignant neoplasm without specification of site
0.707 0.293 0.000
T39.1 4-Aminophenol derivatives
0.707 0.293 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.707 0.293 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.706 0.294 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.706 0.294 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.706 0.294 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.705 0.295 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.705 0.295 0.000
R57 Shock, not elsewhere classified
0.704 0.295 0.000
R73 Elevated blood glucose level
0.704 0.296 0.000
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs
0.704 0.296 0.000
C78.1 Secondary malignant neoplasm of mediastinum
0.704 0.296 0.000
W19.8 Other specified place
0.704 0.296 0.000
W19.5 Trade and service area
0.704 0.296 0.000
W19.0 Home
0.704 0.296 0.000
W19.7 Farm
0.704 0.296 0.000
W19.6 Industrial and construction area
0.704 0.296 0.000
W19.3 Sports and athletics area
0.704 0.296 0.000
R52.0 Acute pain
0.703 0.296 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.703 0.297 0.000
S02.8 Fractures of other skull and facial bones
0.703 0.297 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.703 0.297 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.702 0.298 0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.702 0.298 0.000
S02.5 Fracture of tooth
0.701 0.299 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.699 0.300 0.000
I62.0 Subdural haemorrhage (acute) (nontraumatic)
0.699 0.301 0.000
S40 Superficial injury of shoulder and upper arm
0.699 0.301 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.698 0.302 0.000
R58 Haemorrhage, not elsewhere classified
0.698 0.302 0.000
I98.2 Oesophageal varices in diseases classified elsewhere
0.698 0.302 0.000
R54 Senility
0.697 0.303 0.000
T91 Sequelae of injuries of neck and trunk
0.697 0.303 0.000
Y52 Agents primarily affecting the cardiovascular system
0.697 0.303 0.000
V20-V29 Motorcycle rider injured in transport accident
0.696 0.303 0.000
R20.3 Hyperaesthesia
0.696 0.304 0.000
R20.1 Hypoaesthesia of skin
0.696 0.304 0.000
R20.0 Anaesthesia of skin
0.696 0.304 0.000
R59 Enlarged lymph nodes
0.694 0.306 0.000
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system
0.693 0.307 0.000
C79.1 Secondary malignant neoplasm of bladder and other and unspecified urinary organs
0.693 0.307 0.000
C79.0 Secondary malignant neoplasm of kidney and renal pelvis
0.693 0.307 0.000
R00.0 Tachycardia, unspecified
0.693 0.307 0.000
S02.9 Fracture of skull and facial bones, part unspecified
0.692 0.308 0.000
S02.7 Multiple fractures involving skull and facial bones
0.692 0.308 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.692 0.308 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.692 0.308 0.000
W02 Fall involving ice-skates, skis, roller-skates or skateboards
0.692 0.308 0.000
R50.9 Fever, unspecified
0.690 0.310 0.000
R43 Disturbances of smell and taste
0.690 0.310 0.000
I67 Other cerebrovascular diseases
0.689 0.311 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.689 0.311 0.000
T92 Sequelae of injuries of upper limb
0.688 0.311 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.688 0.312 0.000
Q80-Q89 Other congenital malformations
0.686 0.314 0.000
R61 Hyperhidrosis
0.686 0.314 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.686 0.314 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.686 0.314 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.686 0.314 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.686 0.314 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.686 0.314 0.000
T36 Poisoning by systemic antibiotics
0.686 0.314 0.000
Chapter XXII Codes for special purposes
0.685 0.315 0.000
O75.2 Pyrexia during labour, not elsewhere classified
0.683 0.317 0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis
0.683 0.317 0.000
T78 Adverse effects, not elsewhere classified
0.682 0.318 0.000
R26.2 Difficulty in walking, not elsewhere classified
0.681 0.319 0.000
S64 Injury of nerves at wrist and hand level
0.681 0.319 0.000
C81 Hodgkin's disease
0.681 0.319 0.000
R91 Abnormal findings on diagnostic imaging of lung
0.681 0.319 0.000
O73 Retained placenta and membranes, without haemorrhage
0.680 0.320 0.000
I27.0 Primary pulmonary hypertension
0.680 0.320 0.000
R06.0 Dyspnoea
0.678 0.322 0.000
R52.9 Pain, unspecified
0.678 0.322 0.000
Q61.2 Polycystic kidney, adult type
0.678 0.322 0.000
X62 Intentional self-poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified
0.678 0.322 0.000
Chapter X Diseases of the respiratory system
0.678 0.322 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.678 0.322 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.677 0.323 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.676 0.324 0.000
Q35-Q37 Cleft lip and cleft palate
0.676 0.324 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.676 0.324 0.000
R00.8 Other and unspecified abnormalities of heart beat
0.676 0.324 0.000
V49 Car occupant injured in other and unspecified transport accidents
0.674 0.326 0.000
O69 Labour and delivery complicated by umbilical cord complications
0.674 0.326 0.000
C91.0 Acute lymphoblastic leukaemia
0.673 0.327 0.000
S01.2 Open wound of nose
0.672 0.327 0.000
I65.2 Occlusion and stenosis of carotid artery
0.673 0.327 0.000
O63.9 Long labour, unspecified
0.672 0.328 0.000
S32 Fracture of lumbar spine and pelvis
0.671 0.329 0.000
O68.1 Labour and delivery complicated by meconium in amniotic fluid
0.670 0.329 0.000
Y88 Sequelae of surgical and medical care as external cause
0.670 0.330 0.000
S01.5 Open wound of lip and oral cavity
0.668 0.332 0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified
0.668 0.332 0.000
O12 Gestational [pregnancy-induced] oedema and proteinuria without hypertension
0.667 0.333 0.000
Q61.0 Congenital single renal cyst
0.666 0.333 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.666 0.334 0.000
O85-O92 Complications predominantly related to the puerperium
0.666 0.334 0.000
R23.8 Other and unspecified skin changes
0.665 0.335 0.000
C50-C50 Malignant neoplasm of breast
0.664 0.336 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.663 0.337 0.000
C95 Leukaemia of unspecified cell type
0.663 0.337 0.000
C94 Other leukaemias of specified cell type
0.663 0.337 0.000
C93 Monocytic leukaemia
0.663 0.337 0.000
C88 Malignant immunoproliferative diseases
0.663 0.337 0.000
C86 Other specified types of T/NK-cell lymphoma
0.663 0.337 0.000
S09.9 Unspecified injury of head
0.663 0.337 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.661 0.339 0.000
R77 Other abnormalities of plasma proteins
0.661 0.339 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.660 0.340 0.000
R06.5 Mouth breathing
0.660 0.340 0.000
R87.6 Abnormal cytological findings
0.659 0.341 0.000
R56.0 Febrile convulsions
0.659 0.341 0.000
Q63 Other congenital malformations of kidney
0.659 0.341 0.000
R05 Cough
0.659 0.341 0.000
O16 Unspecified maternal hypertension
0.658 0.342 0.000
S02.21 Fracture of nasal bones (open)
0.657 0.342 0.000
T39.0 Salicylates
0.656 0.344 0.000
V43 Car occupant injured in collision with car, pick-up truck or van
0.656 0.344 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.656 0.344 0.000
S42.0 Fracture of clavicle
0.655 0.345 0.000
I34.0 Mitral (valve) insufficiency
0.655 0.345 0.000
O74 Complications of anaesthesia during labour and delivery
0.654 0.346 0.000
O71 Other obstetric trauma
0.654 0.346 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.654 0.346 0.000
O60 Preterm delivery
0.654 0.346 0.000
C51 Malignant neoplasm of vulva
0.653 0.347 0.000
I05 Rheumatic mitral valve diseases
0.653 0.347 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.652 0.347 0.000
I73.8 Other specified peripheral vascular diseases
0.652 0.347 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.652 0.347 0.000
R63 Symptoms and signs concerning food and fluid intake
0.652 0.348 0.000
R85.5 Abnormal microbiological findings
0.652 0.348 0.000
I07 Rheumatic tricuspid valve diseases
0.652 0.348 0.000
S60 Superficial injury of wrist and hand
0.650 0.349 0.000
S70-S79 Injuries to the hip and thigh
0.650 0.350 0.000
R22 Localised swelling, mass and lump of skin and subcutaneous tissue
0.648 0.352 0.000
R41.0 Disorientation, unspecified
0.647 0.353 0.000
R09.2 Respiratory arrest
0.647 0.353 0.000
S27 Injury of other and unspecified intrathoracic organs
0.646 0.354 0.000
C54 Malignant neoplasm of corpus uteri
0.646 0.354 0.000
I34.1 Mitral (valve) prolapse
0.646 0.354 0.000
R94 Abnormal results of function studies
0.646 0.354 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.644 0.355 0.000
J95-J99 Other diseases of the respiratory system
0.644 0.356 0.000
R01 Cardiac murmurs and other cardiac sounds
0.644 0.356 0.000
R89 Abnormal findings in specimens from other organs, systems and tissues
0.643 0.357 0.000
R86 Abnormal findings in specimens from male genital organs
0.643 0.357 0.000
R84 Abnormal findings in specimens from respiratory organs and thorax
0.643 0.357 0.000
R83 Abnormal findings in cerebrospinal fluid
0.643 0.357 0.000
I60.8 Other subarachnoid haemorrhage
0.643 0.357 0.000
S48 Traumatic amputation of shoulder and upper arm
0.643 0.357 0.000
S45 Injury of blood vessels at shoulder and upper arm level
0.643 0.357 0.000
S44 Injury of nerves at shoulder and upper arm level
0.643 0.357 0.000
S47 Crushing injury of shoulder and upper arm
0.643 0.357 0.000
Y59 Other and unspecified vaccines and biological substances
0.643 0.357 0.000
Y58 Bacterial vaccines
0.643 0.357 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.643 0.357 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.643 0.357 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.643 0.357 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.643 0.357 0.000
Y48 Anaesthetics and therapeutic gases
0.643 0.357 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.643 0.357 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.643 0.357 0.000
I74 Arterial embolism and thrombosis
0.643 0.357 0.000
I46 Cardiac arrest
0.641 0.359 0.000
I62.9 Intracranial haemorrhage (nontraumatic), unspecified
0.641 0.359 0.000
W29 Contact with other powered hand tools and household machinery
0.641 0.359 0.000
Y42.5 Other oestrogens and progestogens
0.640 0.360 0.000
I49 Other cardiac arrhythmias
0.640 0.360 0.000
S21 Open wound of thorax
0.639 0.361 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.639 0.361 0.000
Q50-Q56 Congenital malformations of genital organs
0.638 0.362 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.637 0.362 0.000
O66 Other obstructed labour
0.637 0.363 0.000
R82 Other abnormal findings in urine
0.635 0.364 0.000
R50.8 Other specified fever
0.635 0.365 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.633 0.367 0.000
R06.6 Hiccough
0.632 0.367 0.000
W06.2 School, other institution and public administrative area
0.632 0.368 0.000
W06.8 Other specified place
0.632 0.368 0.000
W06.7 Farm
0.632 0.368 0.000
W06.6 Industrial and construction area
0.632 0.368 0.000
W06.5 Trade and service area
0.632 0.368 0.000
W06.4 Street and highway
0.632 0.368 0.000
W06.3 Sports and athletics area
0.632 0.368 0.000
W06.1 Residential institution
0.632 0.368 0.000
R60.1 Generalised oedema
0.631 0.369 0.000
R60.9 Oedema, unspecified
0.631 0.369 0.000
R06.7 Sneezing
0.631 0.369 0.000
R06.3 Periodic breathing
0.631 0.369 0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.630 0.370 0.000
Q64 Other congenital malformations of urinary system
0.628 0.372 0.000
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter
0.628 0.372 0.000
Q60 Renal agenesis and other reduction defects of kidney
0.628 0.372 0.000
R45 Symptoms and signs involving emotional state
0.628 0.372 0.000
T11 Other injuries of upper limb, level unspecified
0.627 0.373 0.000
O75.7 Vaginal delivery following previous Caesarean section
0.626 0.374 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.625 0.375 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.625 0.375 0.000
T39.4 Antirheumatics, not elsewhere classified
0.625 0.375 0.000
T39.2 Pyrazolone derivatives
0.625 0.375 0.000
R76 Other abnormal immunological findings in serum
0.625 0.375 0.000
R73.9 Hyperglycaemia, unspecified
0.625 0.375 0.000
Y57 Other and unspecified drugs and medicaments
0.625 0.375 0.000
R71 Abnormality of red blood cells
0.625 0.375 0.000
C90.2 Plasmacytoma, extramedullary
0.624 0.376 0.000
R29.4 Clicking hip
0.624 0.376 0.000
R29.3 Abnormal posture
0.624 0.376 0.000
R29.2 Abnormal reflex
0.624 0.376 0.000
R29.1 Meningismus
0.624 0.376 0.000
R29.0 Tetany
0.624 0.376 0.000
I95.9 Hypotension, unspecified
0.624 0.376 0.000
O14 Gestational [pregnancy-induced] hypertension with significant proteinuria
0.624 0.376 0.000
R06.1 Stridor
0.623 0.376 0.000
C90.0 Multiple myeloma
0.623 0.377 0.000
C91.4 Hairy-cell leukaemia
0.623 0.377 0.000
I70 Atherosclerosis
0.623 0.377 0.000
R68.0 Hypothermia, not associated with low environmental temperature
0.623 0.377 0.000
S01.7 Multiple open wounds of head
0.623 0.377 0.000
Y44.2 Anticoagulants
0.623 0.377 0.000
J00-J06 Acute upper respiratory infections
0.623 0.377 0.000
Q00-Q07 Congenital malformations of the nervous system
0.622 0.378 0.000
Q24 Other congenital malformations of heart
0.622 0.378 0.000
C83.8 Other types of diffuse non-Hodgkin's lymphoma
0.622 0.378 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.621 0.378 0.000
R09.0 Asphyxia
0.621 0.379 0.000
R68.8 Other specified general symptoms and signs
0.621 0.379 0.000
I95.8 Other hypotension
0.620 0.380 0.000
I95.0 Idiopathic hypotension
0.620 0.380 0.000
R50.2 Drug-induced fever
0.620 0.380 0.000
R50.1 Persistent fever
0.620 0.380 0.000
Y42.8 Other and unspecified hormones and their synthetic substitutes
0.619 0.381 0.000
J60-J70 Lung diseases due to external agents
0.619 0.381 0.000
R23.1 Pallor
0.619 0.381 0.000
T75 Effects of other external causes
0.618 0.382 0.000
T74 Maltreatment syndromes
0.618 0.382 0.000
T73 Effects of other deprivation
0.618 0.382 0.000
T70 Effects of air pressure and water pressure
0.618 0.382 0.000
T69 Other effects of reduced temperature
0.618 0.382 0.000
T67 Effects of heat and light
0.618 0.382 0.000
T71 Asphyxiation
0.618 0.382 0.000
T66 Unspecified effects of radiation
0.618 0.382 0.000
O67.9 Intrapartum haemorrhage, unspecified
0.617 0.382 0.000
R49.0 Dysphonia
0.617 0.383 0.000
Y89 Sequelae of other external causes
0.616 0.384 0.000
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent
0.616 0.384 0.000
R06.2 Wheezing
0.615 0.385 0.000
J98 Other respiratory disorders
0.615 0.385 0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis
0.612 0.388 0.000
S37 Injury of urinary and pelvic organs
0.612 0.388 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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