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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs116920450
log Bayes Factor = 24.9206
Chromosome 17   position 48,653,130  (GRCh37) Explore rs116920450 on Ensembl!
Variant rs116920450 is part of Cluster X0161

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
1.000 0.000 0.000
Chapter XIV Diseases of the genitourinary system
1.000 0.000 0.000
M15-M19 Arthrosis
0.999 0.001 0.000
Chapter IX Diseases of the circulatory system
0.997 0.003 0.000
Chapter XX External causes of morbidity and mortality
0.997 0.003 0.000
M19 Other arthrosis
0.996 0.004 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.995 0.005 0.000
N30-N39 Other diseases of urinary system
0.995 0.005 0.000
M20-M25 Other joint disorders
0.994 0.006 0.000
M19.9 Arthrosis, unspecified
0.993 0.007 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.991 0.009 0.000
I30-I52 Other forms of heart disease
0.991 0.009 0.000
R00 Abnormalities of heart beat
0.990 0.010 0.000
Chapter XI Diseases of the digestive system
0.983 0.017 0.000
M25 Other joint disorders, not elsewhere classified
0.979 0.021 0.000
K55-K64 Other diseases of intestines
0.979 0.021 0.000
K59 Other functional intestinal disorders
0.979 0.021 0.000
K59.0 Constipation
0.978 0.022 0.000
E70-E90 Metabolic disorders
0.978 0.022 0.000
R30-R39 Symptoms and signs involving the urinary system
0.976 0.024 0.000
R33 Retention of urine
0.976 0.024 0.000
I45 Other conduction disorders
0.974 0.026 0.000
N32 Other disorders of bladder
0.971 0.029 0.000
S00-S09 Injuries to the head
0.969 0.031 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.968 0.032 0.000
M19.97 Arthrosis, unspecified (Ankle and foot)
0.965 0.035 0.000
M25.7 Osteophyte
0.964 0.036 0.000
Chapter VI Diseases of the nervous system
0.963 0.037 0.000
M45-M49 Spondylopathies
0.961 0.039 0.000
K90-K93 Other diseases of the digestive system
0.959 0.041 0.000
R00.0 Tachycardia, unspecified
0.959 0.041 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.958 0.042 0.000
I45.1 Other and unspecified right bundle-branch block
0.956 0.044 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.953 0.047 0.000
Chapter X Diseases of the respiratory system
0.949 0.051 0.000
M20 Acquired deformities of fingers and toes
0.948 0.052 0.000
M25.77 Osteophyte (Ankle and foot)
0.946 0.054 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.944 0.056 0.000
M50-M54 Other dorsopathies
0.943 0.057 0.000
N10-N16 Renal tubulo-interstitial diseases
0.942 0.058 0.000
I50 Heart failure
0.942 0.058 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.941 0.059 0.000
M16 Coxarthrosis [arthrosis of hip]
0.941 0.059 0.000
Chapter VII Diseases of the eye and adnexa
0.929 0.071 0.000
S80-S89 Injuries to the knee and lower leg
0.927 0.073 0.000
R00.2 Palpitations
0.925 0.075 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.924 0.076 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.922 0.078 0.000
K92 Other diseases of digestive system
0.916 0.084 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.906 0.094 0.000
Chapter V Mental and behavioural disorders
0.905 0.095 0.000
N39 Other disorders of urinary system
0.904 0.096 0.000
I50.0 Congestive heart failure
0.904 0.096 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.901 0.099 0.000
N32.8 Other specified disorders of bladder
0.899 0.101 0.000
M19.91 Arthrosis, unspecified (Shoulder region)
0.897 0.103 0.000
S00 Superficial injury of head
0.894 0.106 0.000
E78.0 Pure hypercholesterolaemia
0.891 0.109 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.891 0.109 0.000
J20-J22 Other acute lower respiratory infections
0.888 0.112 0.000
M54 Dorsalgia
0.888 0.112 0.000
R91 Abnormal findings on diagnostic imaging of lung
0.887 0.113 0.000
E20-E35 Disorders of other endocrine glands
0.887 0.113 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.887 0.113 0.000
H53-H54 Visual disturbances and blindness
0.883 0.117 0.000
Chapter II Neoplasms
0.882 0.118 0.000
M47 Spondylosis
0.880 0.120 0.000
M16.1 Other primary coxarthrosis
0.878 0.122 0.000
E78.5 Hyperlipidaemia, unspecified
0.877 0.123 0.000
M19.99 Arthrosis, unspecified (Site unspecified)
0.872 0.128 0.000
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.872 0.128 0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.871 0.129 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.870 0.130 0.000
N40-N51 Diseases of male genital organs
0.869 0.131 0.000
M19.93 Arthrosis, unspecified (Forearm)
0.868 0.132 0.000
N25-N29 Other disorders of kidney and ureter
0.867 0.133 0.000
M48 Other spondylopathies
0.866 0.134 0.000
R02 Gangrene, not elsewhere classified
0.866 0.134 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.864 0.136 0.000
M20.2 Hallux rigidus
0.862 0.138 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.862 0.138 0.000
N17-N19 Renal failure
0.861 0.139 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.859 0.141 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.857 0.143 0.000
K62 Other diseases of anus and rectum
0.854 0.146 0.000
N00-N08 Glomerular diseases
0.853 0.147 0.000
I60-I69 Cerebrovascular diseases
0.852 0.148 0.000
Chapter VIII Diseases of the ear and mastoid process
0.852 0.148 0.000
S60-S69 Injuries to the wrist and hand
0.851 0.149 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.850 0.150 0.000
R00.1 Bradycardia, unspecified
0.848 0.152 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.848 0.152 0.000
M17 Gonarthrosis [arthrosis of knee]
0.847 0.153 0.000
M20.3 Other deformity of hallux (acquired)
0.847 0.153 0.000
J22 Unspecified acute lower respiratory infection
0.844 0.156 0.000
S01 Open wound of head
0.843 0.157 0.000
M20.4 Other hammer toe(s) (acquired)
0.842 0.158 0.000
I34 Nonrheumatic mitral valve disorders
0.841 0.159 0.000
H53 Visual disturbances
0.840 0.160 0.000
K92.1 Melaena
0.840 0.160 0.000
O60-O75 Complications of labour and delivery
0.840 0.160 0.000
N32.0 Bladder-neck obstruction
0.835 0.165 0.000
E10-E14 Diabetes mellitus
0.834 0.166 0.000
N12 Tubulo-interstitial nephritis, not specified as acute or chronic
0.832 0.168 0.000
R03 Abnormal blood-pressure reading, without diagnosis
0.831 0.169 0.000
K55 Vascular disorders of intestine
0.829 0.171 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.828 0.172 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.828 0.172 0.000
K92.0 Haematemesis
0.823 0.177 0.000
N31 Neuromuscular dysfunction of bladder, not elsewhere classified
0.823 0.177 0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis
0.822 0.178 0.000
V10-V19 Pedal cyclist injured in transport accident
0.821 0.179 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.820 0.180 0.000
R01 Cardiac murmurs and other cardiac sounds
0.820 0.180 0.000
M16.0 Primary coxarthrosis, bilateral
0.819 0.181 0.000
M19.94 Arthrosis, unspecified (Hand)
0.818 0.182 0.000
S81 Open wound of lower leg
0.817 0.183 0.000
J30-J39 Other diseases of upper respiratory tract
0.817 0.183 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.814 0.186 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.812 0.188 0.000
I44 Atrioventricular and left bundle-branch block
0.806 0.194 0.000
J90-J94 Other diseases of pleura
0.805 0.195 0.000
R42 Dizziness and giddiness
0.805 0.195 0.000
L60-L75 Disorders of skin appendages
0.804 0.196 0.000
M54.5 Low back pain
0.802 0.198 0.000
D00-D09 In situ neoplasms
0.802 0.198 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.801 0.199 0.000
I45.2 Bifascicular block
0.800 0.200 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.799 0.201 0.000
M48.0 Spinal stenosis
0.799 0.201 0.000
M17.1 Other primary gonarthrosis
0.798 0.202 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.795 0.205 0.000
M25.75 Osteophyte (Pelvic region and thigh)
0.794 0.206 0.000
M25.9 Joint disorder, unspecified
0.794 0.206 0.000
E83 Disorders of mineral metabolism
0.792 0.208 0.000
M21 Other acquired deformities of limbs
0.791 0.209 0.000
I67 Other cerebrovascular diseases
0.791 0.209 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.788 0.212 0.000
M25.8 Other specified joint disorders
0.788 0.212 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.785 0.215 0.000
W20-W49 Exposure to inanimate mechanical forces
0.785 0.215 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.783 0.217 0.000
N40 Hyperplasia of prostate
0.783 0.217 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.783 0.217 0.000
N32.1 Vesicointestinal fistula
0.782 0.218 0.000
N36 Other disorders of urethra
0.779 0.221 0.000
O63 Long labour
0.779 0.221 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.779 0.221 0.000
N19 Unspecified renal failure
0.779 0.221 0.000
M19.0 Primary arthrosis of other joints
0.778 0.222 0.000
Y83.4 Other reconstructive surgery
0.778 0.222 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.777 0.223 0.000
K56 Paralytic ileus and intestinal obstruction without hernia
0.776 0.224 0.000
R06 Abnormalities of breathing
0.775 0.225 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.775 0.225 0.000
N39.0 Urinary tract infection, site not specified
0.775 0.225 0.000
S82 Fracture of lower leg, including ankle
0.775 0.225 0.000
N39.8 Other specified disorders of urinary system
0.774 0.226 0.000
X20-X29 Contact with venomous animals and plants
0.772 0.228 0.000
Y52 Agents primarily affecting the cardiovascular system
0.772 0.228 0.000
N28 Other disorders of kidney and ureter, not elsewhere classified
0.772 0.228 0.000
J40-J47 Chronic lower respiratory diseases
0.771 0.229 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.770 0.230 0.000
F30-F39 Mood [affective] disorders
0.770 0.230 0.000
M54.3 Sciatica
0.770 0.230 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.769 0.230 0.000
N70-N77 Inflammatory diseases of female pelvic organs
0.769 0.231 0.000
M47.9 Spondylosis, unspecified
0.769 0.231 0.000
S06 Intracranial injury
0.767 0.233 0.000
O42 Premature rupture of membranes
0.767 0.233 0.000
K59.1 Functional diarrhoea
0.766 0.234 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.766 0.234 0.000
I35 Nonrheumatic aortic valve disorders
0.766 0.234 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.765 0.234 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.765 0.235 0.000
G81 Hemiplegia
0.764 0.236 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.764 0.236 0.000
I20-I25 Ischaemic heart diseases
0.764 0.236 0.000
N32.3 Diverticulum of bladder
0.763 0.237 0.000
N48 Other disorders of penis
0.763 0.237 0.000
N13 Obstructive and reflux uropathy
0.763 0.237 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.762 0.238 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.761 0.239 0.000
K91.8 Other postprocedural disorders of digestive system, not elsewhere classified
0.761 0.239 0.000
R90 Abnormal findings on diagnostic imaging of central nervous system
0.761 0.239 0.000
R39 Other symptoms and signs involving the urinary system
0.761 0.239 0.000
J34 Other disorders of nose and nasal sinuses
0.760 0.240 0.000
X60-X84 Intentional self-harm
0.760 0.240 0.000
S00.2 Other superficial injuries of eyelid and periocular area
0.760 0.240 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.759 0.241 0.000
S09 Other and unspecified injuries of head
0.757 0.243 0.000
T66-T78 Other and unspecified effects of external causes
0.755 0.245 0.000
N39.9 Disorder of urinary system, unspecified
0.755 0.245 0.000
N10 Acute tubulo-interstitial nephritis
0.751 0.249 0.000
T79-T79 Certain early complications of trauma
0.751 0.249 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.750 0.250 0.000
S39.9 Unspecified injury of abdomen, lower back and pelvis
0.750 0.250 0.000
K61 Abscess of anal and rectal regions
0.748 0.251 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.748 0.252 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.746 0.254 0.000
I49 Other cardiac arrhythmias
0.746 0.254 0.000
H10-H13 Disorders of conjunctiva
0.745 0.255 0.000
N99-N99 Other disorders of the genitourinary system
0.745 0.255 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.745 0.255 0.000
M86-M90 Other osteopathies
0.745 0.255 0.000
M50 Cervical disk disorders
0.743 0.257 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.742 0.258 0.000
K04 Diseases of pulp and periapical tissues
0.741 0.259 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.740 0.260 0.000
F60-F69 Disorders of adult personality and behaviour
0.740 0.260 0.000
T81 Complications of procedures, not elsewhere classified
0.740 0.260 0.000
N45 Orchitis and epididymitis
0.739 0.261 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.739 0.261 0.000
S81.0 Open wound of knee
0.738 0.262 0.000
K59.8 Other specified functional intestinal disorders
0.738 0.262 0.000
S62 Fracture at wrist and hand level
0.738 0.262 0.000
G40-G47 Episodic and paroxysmal disorders
0.737 0.263 0.000
S00.0 Superficial injury of scalp
0.737 0.263 0.000
Y84.2 Radiological procedure and radiotherapy
0.737 0.263 0.000
N28.9 Disorder of kidney and ureter, unspecified
0.736 0.264 0.000
N11 Chronic tubulo-interstitial nephritis
0.736 0.264 0.000
I34.1 Mitral (valve) prolapse
0.736 0.264 0.000
Chapter XXI Factors influencing health status and contact with health services
0.735 0.265 0.000
I46 Cardiac arrest
0.734 0.265 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.734 0.266 0.000
E88 Other metabolic disorders
0.733 0.267 0.000
N30 Cystitis
0.732 0.268 0.000
I50.9 Heart failure, unspecified
0.731 0.269 0.000
K92.9 Disease of digestive system, unspecified
0.730 0.270 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.730 0.270 0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.730 0.270 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.730 0.270 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.730 0.270 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.728 0.272 0.000
Chapter XXII Codes for special purposes
0.728 0.272 0.000
S70-S79 Injuries to the hip and thigh
0.727 0.272 0.000
H53.9 Visual disturbance, unspecified
0.726 0.274 0.000
R21 Rash and other nonspecific skin eruption
0.726 0.274 0.000
M40-M43 Deforming dorsopathies
0.726 0.274 0.000
M18 Arthrosis of first carpometacarpal joint
0.726 0.274 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.725 0.275 0.000
K62.3 Rectal prolapse
0.725 0.275 0.000
E22 Hyperfunction of pituitary gland
0.725 0.275 0.000
H53.8 Other visual disturbances
0.724 0.276 0.000
M25.5 Pain in joint
0.724 0.276 0.000
M48.06 Spinal stenosis (Lumbar region)
0.724 0.276 0.000
G20-G26 Extrapyramidal and movement disorders
0.723 0.277 0.000
H65-H75 Diseases of middle ear and mastoid
0.721 0.279 0.000
I67.8 Other specified cerebrovascular diseases
0.721 0.279 0.000
O63.1 Prolonged second stage (of labour)
0.720 0.280 0.000
M47.2 Other spondylosis with radiculopathy
0.719 0.281 0.000
J34.2 Deviated nasal septum
0.718 0.282 0.000
M22 Disorders of patella
0.717 0.282 0.000
N60-N64 Disorders of breast
0.717 0.283 0.000
M91-M94 Chondropathies
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
S10-S19 Injuries to the neck
0.717 0.283 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.717 0.283 0.000
M15 Polyarthrosis
0.717 0.283 0.000
R47-R49 Symptoms and signs involving speech and voice
0.716 0.284 0.000
M25.74 Osteophyte (Hand)
0.716 0.284 0.000
I00-I02 Acute rheumatic fever
0.715 0.285 0.000
S20-S29 Injuries to the thorax
0.715 0.285 0.000
Y35-Y36 Legal intervention and operations of war
0.715 0.285 0.000
Y10-Y34 Event of undetermined intent
0.715 0.285 0.000
Y00-Y09 Assault
0.715 0.285 0.000
X85-X99 Assault
0.715 0.285 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.715 0.285 0.000
X50-X57 Overexertion, travel and privation
0.715 0.285 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.715 0.285 0.000
X30-X39 Exposure to forces of nature
0.715 0.285 0.000
X10-X19 Contact with heat and hot substances
0.715 0.285 0.000
X00-X09 Exposure to smoke, fire and flames
0.715 0.285 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.715 0.285 0.000
W75-W84 Other accidental threats to breathing
0.715 0.285 0.000
W65-W74 Accidental drowning and submersion
0.715 0.285 0.000
W50-W64 Exposure to animate mechanical forces
0.715 0.285 0.000
V98-V99 Other and unspecified transport accidents
0.715 0.285 0.000
V95-V97 Air and space transport accidents
0.715 0.285 0.000
V90-V94 Water transport accidents
0.715 0.285 0.000
V80-V89 Other land transport accidents
0.715 0.285 0.000
V70-V79 Bus occupant injured in transport accident
0.715 0.285 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.715 0.285 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.715 0.285 0.000
V40-V49 Car occupant injured in transport accident
0.715 0.285 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.715 0.285 0.000
V20-V29 Motorcycle rider injured in transport accident
0.715 0.285 0.000
V01-V09 Pedestrian injured in transport accident
0.715 0.285 0.000
C64-C68 Malignant neoplasms of urinary tract
0.715 0.285 0.000
M80-M85 Disorders of bone density and structure
0.715 0.285 0.000
M19.8 Other specified arthrosis
0.714 0.286 0.000
M19.2 Other secondary arthrosis
0.714 0.286 0.000
M19.1 Posttraumatic arthrosis of other joints
0.714 0.286 0.000
T43.2 Other and unspecified antidepressants
0.714 0.286 0.000
N37 Urethral disorders in diseases classified elsewhere
0.713 0.287 0.000
N34 Urethritis and urethral syndrome
0.713 0.287 0.000
N33 Bladder disorders in diseases classified elsewhere
0.713 0.287 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.713 0.287 0.000
M34 Systemic sclerosis
0.713 0.287 0.000
M33 Dermatopolymyositis
0.713 0.287 0.000
M32 Systemic lupus erythematosus
0.713 0.287 0.000
M30 Polyarteritis nodosa and related conditions
0.713 0.287 0.000
E50-E64 Other nutritional deficiencies
0.712 0.288 0.000
M24 Other specific joint derangements
0.712 0.288 0.000
M19.98 Arthrosis, unspecified (Other)
0.712 0.288 0.000
M19.95 Arthrosis, unspecified (Pelvic region and thigh)
0.712 0.288 0.000
M19.92 Arthrosis, unspecified (Upper arm)
0.712 0.288 0.000
N20-N23 Urolithiasis
0.712 0.288 0.000
M46 Other inflammatory spondylopathies
0.711 0.289 0.000
S00.8 Superficial injury of other parts of head
0.711 0.289 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.711 0.289 0.000
E40-E46 Malnutrition
0.711 0.289 0.000
I52 Other heart disorders in diseases classified elsewhere
0.710 0.289 0.000
I48 Atrial fibrillation and flutter
0.710 0.289 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.710 0.289 0.000
I41 Myocarditis in diseases classified elsewhere
0.710 0.289 0.000
I40 Acute myocarditis
0.710 0.289 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.710 0.289 0.000
I37 Pulmonary valve disorders
0.710 0.289 0.000
I36 Nonrheumatic tricuspid valve disorders
0.710 0.289 0.000
I33 Acute and subacute endocarditis
0.710 0.289 0.000
I32 Pericarditis in diseases classified elsewhere
0.710 0.289 0.000
I30 Acute pericarditis
0.710 0.289 0.000
J44 Other chronic obstructive pulmonary disease
0.710 0.290 0.000
L40-L45 Papulosquamous disorders
0.710 0.290 0.000
R00.8 Other and unspecified abnormalities of heart beat
0.710 0.290 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.710 0.290 0.000
M54.4 Lumbago with sciatica
0.710 0.290 0.000
T81.3 Disruption of operation wound, not elsewhere classified
0.709 0.291 0.000
I05-I09 Chronic rheumatic heart diseases
0.709 0.291 0.000
N35 Urethral stricture
0.709 0.291 0.000
E24 Cushing's syndrome
0.708 0.292 0.000
N32.9 Bladder disorder, unspecified
0.706 0.294 0.000
R50-R69 General symptoms and signs
0.706 0.294 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.705 0.295 0.000
K91.4 Colostomy and enterostomy malfunction
0.704 0.296 0.000
N18 Chronic renal failure
0.704 0.296 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.704 0.296 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.702 0.298 0.000
M25.3 Other instability of joint
0.702 0.298 0.000
M25.2 Flail joint
0.702 0.298 0.000
M25.1 Fistula of joint
0.702 0.298 0.000
M25.0 Haemarthrosis
0.702 0.298 0.000
M54.39 Sciatica (Site unspecified)
0.702 0.298 0.000
J93 Pneumothorax
0.702 0.298 0.000
K64 Haemorrhoids and perianal venous thrombosis
0.702 0.298 0.000
K59.9 Functional intestinal disorder, unspecified
0.702 0.298 0.000
K59.4 Anal spasm
0.702 0.298 0.000
K59.3 Megacolon, not elsewhere classified
0.702 0.298 0.000
K59.2 Neurogenic bowel, not elsewhere classified
0.702 0.298 0.000
E14 Unspecified diabetes mellitus
0.702 0.298 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.701 0.299 0.000
E85 Amyloidosis
0.701 0.299 0.000
E84 Cystic fibrosis
0.701 0.299 0.000
E79 Disorders of purine and pyrimidine metabolism
0.701 0.299 0.000
E77 Disorders of glycoprotein metabolism
0.701 0.299 0.000
E76 Disorders of glycosaminoglycan metabolism
0.701 0.299 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.701 0.299 0.000
E74 Other disorders of carbohydrate metabolism
0.701 0.299 0.000
E73 Lactose intolerance
0.701 0.299 0.000
E72 Other disorders of amino-acid metabolism
0.701 0.299 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.701 0.299 0.000
E70 Disorders of aromatic amino-acid metabolism
0.701 0.299 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.701 0.299 0.000
S89 Other and unspecified injuries of lower leg
0.701 0.299 0.000
M70-M79 Other soft tissue disorders
0.701 0.299 0.000
R20 Disturbances of skin sensation
0.701 0.299 0.000
N31.8 Other neuromuscular dysfunction of bladder
0.700 0.300 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.700 0.300 0.000
D80-D89 Certain disorders involving the immune mechanism
0.700 0.300 0.000
R36 Urethral discharge
0.700 0.300 0.000
R34 Anuria and oliguria
0.700 0.300 0.000
I44.2 Atrioventricular block, complete
0.700 0.300 0.000
H90-H95 Other disorders of ear
0.699 0.301 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.699 0.301 0.000
Y83.2 Surgical operation with anastomosis, bypass or graft
0.699 0.301 0.000
I45.9 Conduction disorder, unspecified
0.699 0.301 0.000
I45.8 Other specified conduction disorders
0.699 0.301 0.000
I45.6 Preexcitation syndrome
0.699 0.301 0.000
I45.5 Other specified heart block
0.699 0.301 0.000
I45.4 Nonspecific intraventricular block
0.699 0.301 0.000
I45.3 Trifascicular block
0.699 0.301 0.000
I45.0 Right fascicular block
0.699 0.301 0.000
K10 Other diseases of jaws
0.699 0.301 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.698 0.302 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.696 0.303 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.696 0.304 0.000
N32.4 Rupture of bladder, nontraumatic
0.696 0.304 0.000
N32.2 Vesical fistula, not elsewhere classified
0.696 0.304 0.000
J92 Pleural plaque
0.696 0.304 0.000
N02 Recurrent and persistent haematuria
0.695 0.305 0.000
V18 Pedal cyclist injured in noncollision transport accident
0.695 0.305 0.000
Y84.0 Cardiac catheterisation
0.695 0.305 0.000
S08 Traumatic amputation of part of head
0.695 0.305 0.000
S07 Crushing injury of head
0.695 0.305 0.000
S05 Injury of eye and orbit
0.695 0.305 0.000
S04 Injury of cranial nerves
0.695 0.305 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.695 0.305 0.000
M31 Other necrotising vasculopathies
0.695 0.305 0.000
S90-S99 Injuries to the ankle and foot
0.695 0.305 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.694 0.306 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.694 0.306 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.694 0.306 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.694 0.306 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.694 0.306 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.694 0.306 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.694 0.306 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.694 0.306 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.694 0.306 0.000
T36 Poisoning by systemic antibiotics
0.694 0.306 0.000
M54.59 Low back pain (Site unspecified)
0.694 0.306 0.000
L89 Decubitus ulcer
0.694 0.306 0.000
Y85 Sequelae of transport accidents
0.694 0.306 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.693 0.307 0.000
R01.1 Cardiac murmur, unspecified
0.693 0.307 0.000
G81.9 Hemiplegia, unspecified
0.693 0.307 0.000
K55.2 Angiodysplasia of colon
0.693 0.307 0.000
R03.0 Elevated blood-pressure reading, without diagnosis of hypertension
0.693 0.307 0.000
Y84.6 Urinary catheterisation
0.692 0.308 0.000
M25.79 Osteophyte (Site unspecified)
0.691 0.309 0.000
M25.73 Osteophyte (Forearm)
0.691 0.309 0.000
M25.72 Osteophyte (Upper arm)
0.691 0.309 0.000
M25.71 Osteophyte (Shoulder region)
0.691 0.309 0.000
M25.70 Osteophyte (Multiple sites)
0.691 0.309 0.000
G70-G73 Diseases of myoneural junction and muscle
0.691 0.309 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.691 0.309 0.000
H54 Blindness and low vision
0.691 0.309 0.000
S40-S49 Injuries to the shoulder and upper arm
0.691 0.309 0.000
K62.8 Other specified diseases of anus and rectum
0.690 0.310 0.000
H04 Disorders of lachrymal system
0.690 0.310 0.000
M54.56 Low back pain (Lumbar region)
0.689 0.311 0.000
R06.5 Mouth breathing
0.689 0.311 0.000
H55-H59 Other disorders of eye and adnexa
0.689 0.311 0.000
M49 Spondylopathies in diseases classified elsewhere
0.689 0.311 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.688 0.312 0.000
K07 Dentofacial anomalies [including malocclusion]
0.687 0.313 0.000
O66 Other obstructed labour
0.687 0.313 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.687 0.313 0.000
M25.78 Osteophyte (Other)
0.686 0.314 0.000
G30-G32 Other degenerative diseases of the nervous system
0.686 0.314 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.685 0.315 0.000
O48 Prolonged pregnancy
0.685 0.315 0.000
G51 Facial nerve disorders
0.685 0.315 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.685 0.315 0.000
E78.9 Disorder of lipoprotein metabolism, unspecified
0.683 0.316 0.000
E78.8 Other disorders of lipoprotein metabolism
0.683 0.316 0.000
E78.6 Lipoprotein deficiency
0.683 0.316 0.000
E78.4 Other hyperlipidaemia
0.683 0.316 0.000
E78.3 Hyperchylomicronaemia
0.683 0.316 0.000
E78.2 Mixed hyperlipidaemia
0.683 0.316 0.000
E78.1 Pure hyperglyceridaemia
0.683 0.316 0.000
M47.8 Other spondylosis
0.683 0.317 0.000
S32 Fracture of lumbar spine and pelvis
0.682 0.318 0.000
S01.0 Open wound of scalp
0.682 0.318 0.000
M19.96 Arthrosis, unspecified-Lower leg
0.682 0.318 0.000
H53.2 Diplopia
0.682 0.318 0.000
Y88 Sequelae of surgical and medical care as external cause
0.681 0.319 0.000
N04 Nephrotic syndrome
0.681 0.319 0.000
G82 Paraplegia and tetraplegia
0.681 0.319 0.000
K62.1 Rectal polyp
0.681 0.319 0.000
L97 Ulcer of lower limb, not elsewhere classified
0.680 0.320 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.680 0.320 0.000
S01.9 Open wound of head, part unspecified
0.680 0.320 0.000
I84 Haemorrhoids
0.680 0.320 0.000
Y43 Primarily systemic agents
0.680 0.320 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.680 0.320 0.000
M20.0 Deformity of finger(s)
0.680 0.320 0.000
S80 Superficial injury of lower leg
0.679 0.321 0.000
I44.3 Other and unspecified atrioventricular block
0.679 0.321 0.000
C51-C58 Malignant neoplasms of female genital organs
0.678 0.322 0.000
E83.4 Disorders of magnesium metabolism
0.678 0.322 0.000
M51 Other intervertebral disk disorders
0.678 0.322 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.678 0.322 0.000
M54.2 Cervicalgia
0.677 0.323 0.000
R92 Abnormal findings on diagnostic imaging of breast
0.677 0.323 0.000
G35 Multiple sclerosis
0.677 0.323 0.000
R79 Other abnormal findings of blood chemistry
0.676 0.324 0.000
M53 Other dorsopathies, not elsewhere classified
0.676 0.324 0.000
N16 Renal tubulo-interstitial disorders in diseases classified elsewhere
0.676 0.324 0.000
N15 Other renal tubulo-interstitial diseases
0.676 0.324 0.000
N14 Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
0.676 0.324 0.000
Y52.3 Coronary vasodilators, not elsewhere classified
0.675 0.325 0.000
C34 Malignant neoplasm of bronchus and lung
0.675 0.325 0.000
L10-L14 Bullous disorders
0.675 0.325 0.000
M16.7 Other secondary coxarthrosis
0.675 0.325 0.000
M16.6 Other secondary coxarthrosis, bilateral
0.675 0.325 0.000
M16.5 Other posttraumatic coxarthrosis
0.675 0.325 0.000
M16.4 Posttraumatic coxarthrosis, bilateral
0.675 0.325 0.000
M16.3 Other dysplastic coxarthrosis
0.675 0.325 0.000
M16.2 Coxarthrosis resulting from dysplasia, bilateral
0.675 0.325 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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