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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs116954357
log Bayes Factor = 6.54721
Chromosome 19   position 20,223,681  (GRCh37) Explore rs116954357 on Ensembl!
Variant rs116954357 is part of Cluster X0102

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I30-I52 Other forms of heart disease
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
# Top node
0.999 0.001 0.000
Chapter IX Diseases of the circulatory system
0.999 0.001 0.000
I44 Atrioventricular and left bundle-branch block
0.999 0.001 0.000
I50 Heart failure
0.998 0.002 0.000
M05-M14 Inflammatory polyarthropathies
0.995 0.005 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.991 0.009 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.986 0.014 0.000
I50.1 Left ventricular failure
0.981 0.019 0.000
I45 Other conduction disorders
0.980 0.020 0.000
M06 Other rheumatoid arthritis
0.979 0.021 0.000
I44.7 Left bundle-branch block, unspecified
0.977 0.023 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.971 0.029 0.000
M15-M19 Arthrosis
0.966 0.034 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.963 0.037 0.000
M06.9 Rheumatoid arthritis, unspecified
0.962 0.038 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.960 0.040 0.000
M19 Other arthrosis
0.960 0.040 0.000
I51 Complications and ill-defined descriptions of heart disease
0.957 0.043 0.000
M19.9 Arthrosis, unspecified
0.953 0.047 0.000
I44.2 Atrioventricular block, complete
0.951 0.049 0.000
M19.91 Arthrosis, unspecified (Shoulder region)
0.949 0.051 0.000
Chapter XX External causes of morbidity and mortality
0.948 0.052 0.000
M10 Gout
0.939 0.061 0.000
M19.97 Arthrosis, unspecified (Ankle and foot)
0.937 0.063 0.000
I45.1 Other and unspecified right bundle-branch block
0.937 0.063 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.934 0.066 0.000
I50.0 Congestive heart failure
0.934 0.066 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.926 0.074 0.000
I44.0 Atrioventricular block, first degree
0.924 0.076 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.924 0.076 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.915 0.085 0.000
M20-M25 Other joint disorders
0.912 0.088 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.911 0.089 0.000
M65-M68 Disorders of synovium and tendon
0.903 0.097 0.000
M10.9 Gout, unspecified
0.900 0.100 0.000
M70-M79 Other soft tissue disorders
0.899 0.101 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.894 0.106 0.000
S90-S99 Injuries to the ankle and foot
0.888 0.112 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.880 0.120 0.000
M40-M43 Deforming dorsopathies
0.879 0.121 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.877 0.123 0.000
I47 Paroxysmal tachycardia
0.877 0.123 0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts
0.876 0.124 0.000
S60-S69 Injuries to the wrist and hand
0.875 0.125 0.000
I50.9 Heart failure, unspecified
0.871 0.129 0.000
D68 Other coagulation defects
0.871 0.129 0.000
I51.8 Other ill-defined heart diseases
0.870 0.130 0.000
I30 Acute pericarditis
0.864 0.136 0.000
M75 Shoulder lesions
0.863 0.137 0.000
M24 Other specific joint derangements
0.862 0.138 0.000
M00-M03 Infectious arthropathies
0.859 0.141 0.000
T86 Failure and rejection of transplanted organs and tissues
0.856 0.144 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.855 0.145 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.853 0.147 0.000
I47.2 Ventricular tachycardia
0.852 0.148 0.000
I72 Other aneurysm
0.849 0.151 0.000
T79-T79 Certain early complications of trauma
0.848 0.152 0.000
Y40 Systemic antibiotics
0.841 0.159 0.000
S10-S19 Injuries to the neck
0.841 0.159 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.838 0.162 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.838 0.162 0.000
Y57 Other and unspecified drugs and medicaments
0.837 0.163 0.000
D69 Purpura and other haemorrhagic conditions
0.834 0.166 0.000
Chapter V Mental and behavioural disorders
0.833 0.167 0.000
M10.99 Gout, unspecified (Site unspecified)
0.833 0.167 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.831 0.169 0.000
T51 Toxic effect of alcohol
0.829 0.171 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.822 0.178 0.000
M21 Other acquired deformities of limbs
0.821 0.179 0.000
I45.6 Preexcitation syndrome
0.820 0.180 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.819 0.181 0.000
M05 Seropositive rheumatoid arthritis
0.814 0.186 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.814 0.186 0.000
D60-D64 Aplastic and other anaemias
0.811 0.189 0.000
I42 Cardiomyopathy
0.806 0.194 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.805 0.195 0.000
M86-M90 Other osteopathies
0.802 0.198 0.000
S62 Fracture at wrist and hand level
0.802 0.198 0.000
S90 Superficial injury of ankle and foot
0.800 0.200 0.000
T80.8 Other complications following infusion, transfusion and therapeutic injection
0.797 0.203 0.000
T84.1 Mechanical complication of internal fixation device of bones of limb
0.795 0.205 0.000
I74 Arterial embolism and thrombosis
0.793 0.207 0.000
I51.7 Cardiomegaly
0.789 0.211 0.000
V80-V89 Other land transport accidents
0.788 0.212 0.000
M18 Arthrosis of first carpometacarpal joint
0.787 0.213 0.000
M33 Dermatopolymyositis
0.786 0.214 0.000
I45.9 Conduction disorder, unspecified
0.785 0.214 0.000
M91-M94 Chondropathies
0.785 0.215 0.000
T43.2 Other and unspecified antidepressants
0.783 0.217 0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]
0.782 0.218 0.000
Y44 Agents primarily affecting blood constituents
0.782 0.218 0.000
D80-D89 Certain disorders involving the immune mechanism
0.780 0.220 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.780 0.220 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.779 0.221 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.776 0.224 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.775 0.225 0.000
M10.97 Gout, unspecified (Ankle and foot)
0.774 0.226 0.000
T86.1 Kidney transplant failure and rejection
0.774 0.226 0.000
M65 Synovitis and tenosynovitis
0.772 0.228 0.000
I77 Other disorders of arteries and arterioles
0.770 0.230 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.768 0.232 0.000
D68.8 Other specified coagulation defects
0.767 0.233 0.000
I30.9 Acute pericarditis, unspecified
0.766 0.234 0.000
M19.90 Arthrosis, unspecified (Multiple sites)
0.765 0.235 0.000
M19.0 Primary arthrosis of other joints
0.765 0.235 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.764 0.236 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.760 0.240 0.000
T88.8 Other specified complications of surgical and medical care, not elsewhere classified
0.759 0.241 0.000
M00 Pyogenic arthritis
0.758 0.242 0.000
X20-X29 Contact with venomous animals and plants
0.758 0.242 0.000
M67 Other disorders of synovium and tendon
0.757 0.243 0.000
M06.3 Rheumatoid nodule
0.757 0.243 0.000
T42.4 Benzodiazepines
0.756 0.244 0.000
M43 Other deforming dorsopathies
0.755 0.245 0.000
M19.2 Other secondary arthrosis
0.753 0.247 0.000
D69.6 Thrombocytopenia, unspecified
0.753 0.247 0.000
I36 Nonrheumatic tricuspid valve disorders
0.751 0.249 0.000
T51.0 Ethanol
0.751 0.249 0.000
M60-M63 Disorders of muscles
0.750 0.250 0.000
T80.2 Infections following infusion, transfusion and therapeutic injection
0.748 0.252 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.746 0.253 0.000
M31 Other necrotising vasculopathies
0.745 0.255 0.000
M19.93 Arthrosis, unspecified (Forearm)
0.744 0.256 0.000
I51.9 Heart disease, unspecified
0.744 0.256 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.743 0.257 0.000
T50.9 Other and unspecified drugs, medicaments and biological substances
0.743 0.257 0.000
X50-X57 Overexertion, travel and privation
0.742 0.258 0.000
I45.3 Trifascicular block
0.742 0.258 0.000
M75.4 Impingement syndrome of shoulder
0.742 0.258 0.000
M06.4 Inflammatory polyarthropathy
0.741 0.259 0.000
D61 Other aplastic anaemias
0.741 0.259 0.000
T84.3 Mechanical complication of other bone devices, implants and grafts
0.740 0.260 0.000
I33 Acute and subacute endocarditis
0.740 0.260 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.740 0.260 0.000
Y43 Primarily systemic agents
0.739 0.261 0.000
I51.0 Cardiac septal defect, acquired
0.739 0.261 0.000
W20-W49 Exposure to inanimate mechanical forces
0.739 0.261 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.738 0.262 0.000
Y57.8 Other drugs and medicaments
0.737 0.263 0.000
M22 Disorders of patella
0.737 0.263 0.000
I45.4 Nonspecific intraventricular block
0.735 0.265 0.000
S62.6 Fracture of other finger
0.734 0.266 0.000
F52 Sexual dysfunction, not caused by organic disorder or disease
0.733 0.267 0.000
I26 Pulmonary embolism
0.733 0.267 0.000
T80.1 Vascular complications following infusion, transfusion and therapeutic injection
0.731 0.269 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.730 0.270 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.729 0.271 0.000
W50-W64 Exposure to animate mechanical forces
0.729 0.271 0.000
I71 Aortic aneurysm and dissection
0.728 0.272 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.728 0.272 0.000
M24.1 Other articular cartilage disorders
0.728 0.272 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.727 0.273 0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft
0.725 0.275 0.000
M18.9 Arthrosis of first carpometacarpal joint, unspecified
0.725 0.275 0.000
D66 Hereditary factor VIII deficiency
0.724 0.275 0.000
I44.1 Atrioventricular block, second degree
0.724 0.276 0.000
M14 Arthropathies in other diseases classified elsewhere
0.724 0.276 0.000
M19.98 Arthrosis, unspecified (Other)
0.723 0.277 0.000
M75.0 Adhesive capsulitis of shoulder
0.723 0.277 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.722 0.278 0.000
M21.1 Varus deformity, not elsewhere classified
0.722 0.278 0.000
S61 Open wound of wrist and hand
0.721 0.279 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.720 0.280 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.720 0.280 0.000
I72.3 Aneurysm of iliac artery
0.719 0.281 0.000
I52 Other heart disorders in diseases classified elsewhere
0.717 0.283 0.000
I48 Atrial fibrillation and flutter
0.717 0.283 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.717 0.283 0.000
I41 Myocarditis in diseases classified elsewhere
0.717 0.283 0.000
I40 Acute myocarditis
0.717 0.283 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.717 0.283 0.000
I32 Pericarditis in diseases classified elsewhere
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.716 0.283 0.000
I00-I02 Acute rheumatic fever
0.716 0.284 0.000
I45.5 Other specified heart block
0.716 0.284 0.000
I44.5 Left posterior fascicular block
0.716 0.284 0.000
I44.4 Left anterior fascicular block
0.716 0.284 0.000
I44.6 Other and unspecified fascicular block
0.714 0.286 0.000
M12 Other specific arthropathies
0.713 0.287 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.713 0.287 0.000
M08 Juvenile arthritis
0.713 0.287 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.713 0.287 0.000
M65.9 Synovitis and tenosynovitis, unspecified
0.712 0.288 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.712 0.288 0.000
T63 Toxic effect of contact with venomous animals
0.711 0.289 0.000
T88.5 Other complications of anaesthesia
0.711 0.289 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.710 0.290 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.710 0.290 0.000
I72.9 Aneurysm of unspecified site
0.709 0.291 0.000
T66-T78 Other and unspecified effects of external causes
0.709 0.291 0.000
Chapter I Certain infectious and parasitic diseases
0.709 0.291 0.000
I51.6 Cardiovascular disease, unspecified
0.708 0.292 0.000
X60-X84 Intentional self-harm
0.707 0.293 0.000
M34 Systemic sclerosis
0.706 0.294 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.706 0.294 0.000
X10-X19 Contact with heat and hot substances
0.706 0.294 0.000
M41 Scoliosis
0.706 0.294 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.705 0.295 0.000
D68.6 Other Thrombophilia
0.705 0.295 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.704 0.296 0.000
M75.1 Rotator cuff syndrome
0.704 0.296 0.000
F52.2 Failure of genital response
0.704 0.296 0.000
M06.0 Seronegative rheumatoid arthritis
0.703 0.297 0.000
I45.8 Other specified conduction disorders
0.702 0.298 0.000
I45.0 Right fascicular block
0.702 0.298 0.000
M06.8 Other specified rheumatoid arthritis
0.702 0.298 0.000
M06.2 Rheumatoid bursitis
0.702 0.298 0.000
M06.1 Adult-onset Still's disease
0.702 0.298 0.000
S90.9 Superficial injury of ankle and foot, unspecified
0.702 0.298 0.000
M21.6 Other acquired deformities of ankle and foot
0.701 0.299 0.000
T20 Burn and corrosion of head and neck
0.700 0.300 0.000
I37 Pulmonary valve disorders
0.699 0.301 0.000
Chapter XXII Codes for special purposes
0.699 0.301 0.000
M77 Other enthesopathies
0.698 0.302 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.697 0.303 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.696 0.303 0.000
M30 Polyarteritis nodosa and related conditions
0.696 0.304 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.696 0.304 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.696 0.304 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.696 0.304 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.696 0.304 0.000
T36 Poisoning by systemic antibiotics
0.696 0.304 0.000
M24.5 Contracture of joint
0.696 0.304 0.000
S62.61 Fracture of other finger (open)
0.695 0.305 0.000
M07 Psoriatic and enteropathic arthropathies
0.694 0.305 0.000
S13 Dislocation, sprain and strain of joints and ligaments at neck level
0.694 0.306 0.000
S70-S79 Injuries to the hip and thigh
0.694 0.306 0.000
Y40.9 Systemic antibiotic, unspecified
0.693 0.307 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.693 0.307 0.000
Y57.9 Drug or medicament, unspecified
0.693 0.307 0.000
M15 Polyarthrosis
0.692 0.308 0.000
Y43.0 Antiallergic and antiemetic drugs
0.692 0.308 0.000
M24.2 Disorder of ligament
0.691 0.308 0.000
D61.9 Aplastic anaemia, unspecified
0.691 0.309 0.000
T31 Burns classified according to extent of body surface involved
0.690 0.310 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.690 0.310 0.000
D68.2 Hereditary deficiency of other clotting factors
0.689 0.311 0.000
M19.8 Other specified arthrosis
0.688 0.312 0.000
S63.4 Traumatic rupture of ligament of finger at metacarpophalangeal and interphalangeal joint(s)
0.687 0.313 0.000
I51.4 Myocarditis, unspecified
0.687 0.313 0.000
M00.9 Pyogenic arthritis, unspecified
0.686 0.314 0.000
I51.5 Myocardial degeneration
0.686 0.314 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.686 0.314 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.686 0.314 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.686 0.314 0.000
M75.5 Bursitis of shoulder
0.686 0.314 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.685 0.314 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.685 0.315 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.685 0.315 0.000
I77.0 Arteriovenous fistula, acquired
0.684 0.316 0.000
D69.5 Secondary thrombocytopenia
0.683 0.317 0.000
M10.94 Gout, unspecified (Hand)
0.681 0.318 0.000
Y35-Y36 Legal intervention and operations of war
0.679 0.321 0.000
Y10-Y34 Event of undetermined intent
0.679 0.321 0.000
Y00-Y09 Assault
0.679 0.321 0.000
X85-X99 Assault
0.679 0.321 0.000
X30-X39 Exposure to forces of nature
0.679 0.321 0.000
X00-X09 Exposure to smoke, fire and flames
0.679 0.321 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.679 0.321 0.000
W75-W84 Other accidental threats to breathing
0.679 0.321 0.000
W65-W74 Accidental drowning and submersion
0.679 0.321 0.000
V98-V99 Other and unspecified transport accidents
0.679 0.321 0.000
V95-V97 Air and space transport accidents
0.679 0.321 0.000
V90-V94 Water transport accidents
0.679 0.321 0.000
V70-V79 Bus occupant injured in transport accident
0.679 0.321 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.679 0.321 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.679 0.321 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.679 0.321 0.000
V01-V09 Pedestrian injured in transport accident
0.679 0.321 0.000
Y44.2 Anticoagulants
0.679 0.321 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.679 0.321 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.678 0.322 0.000
T88.7 Unspecified adverse effect of drug or medicament
0.678 0.322 0.000
T87 Complications peculiar to reattachment and amputation
0.677 0.323 0.000
D68.0 Von Willebrand's disease
0.676 0.324 0.000
M75.2 Bicipital tendinitis
0.676 0.324 0.000
Chapter VI Diseases of the nervous system
0.676 0.324 0.000
S61.9 Open wound of wrist and hand, part unspecified
0.674 0.326 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.674 0.326 0.000
M24.0 Loose body in joint
0.674 0.326 0.000
V89 Motor- or nonmotor-vehicle accident, type of vehicle unspecified
0.674 0.326 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.674 0.326 0.000
M10.4 Other secondary gout
0.673 0.326 0.000
M10.3 Gout due to impairment of renal function
0.673 0.326 0.000
M10.2 Drug-induced gout
0.673 0.326 0.000
M10.1 Lead-induced gout
0.673 0.326 0.000
M10.0 Idiopathic gout
0.673 0.326 0.000
M67.2 Synovial hypertrophy, not elsewhere classified
0.672 0.328 0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level
0.672 0.328 0.000
I44.3 Other and unspecified atrioventricular block
0.672 0.328 0.000
I31 Other diseases of pericardium
0.671 0.329 0.000
M87 Osteonecrosis
0.671 0.329 0.000
Y40.3 Macrolides
0.670 0.330 0.000
Y40.1 Cefalosporins and other -lactam antibiotics
0.670 0.330 0.000
D67 Hereditary factor IX deficiency
0.670 0.330 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.670 0.330 0.000
M19.07 Primary arthrosis of other joints (Ankle and foot)
0.669 0.331 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.669 0.331 0.000
S40-S49 Injuries to the shoulder and upper arm
0.668 0.332 0.000
M66 Spontaneous rupture of synovium and tendon
0.667 0.333 0.000
T86.0 Bone-marrow transplant rejection
0.667 0.333 0.000
D69.9 Haemorrhagic condition, unspecified
0.667 0.333 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.665 0.335 0.000
M43.1 Spondylolisthesis
0.665 0.335 0.000
I42.2 Other hypertrophic cardiomyopathy
0.665 0.335 0.000
S10 Superficial injury of neck
0.665 0.335 0.000
S92 Fracture of foot, except ankle
0.663 0.336 0.000
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.663 0.337 0.000
Y59 Other and unspecified vaccines and biological substances
0.663 0.337 0.000
Y58 Bacterial vaccines
0.663 0.337 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.663 0.337 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.663 0.337 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.663 0.337 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.663 0.337 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.663 0.337 0.000
F99-F99 Unspecified mental disorder
0.661 0.339 0.000
M19.1 Posttraumatic arthrosis of other joints
0.661 0.339 0.000
M94 Other disorders of cartilage
0.660 0.340 0.000
V40-V49 Car occupant injured in transport accident
0.659 0.340 0.000
S50-S59 Injuries to the elbow and forearm
0.659 0.341 0.000
Y48 Anaesthetics and therapeutic gases
0.659 0.341 0.000
S80-S89 Injuries to the knee and lower leg
0.658 0.342 0.000
M13 Other arthritis
0.658 0.342 0.000
I20-I25 Ischaemic heart diseases
0.657 0.343 0.000
Y40.0 Penicillins
0.657 0.343 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.656 0.344 0.000
M33.2 Polymyositis
0.656 0.344 0.000
T80.9 Unspecified complication following infusion, transfusion and therapeutic injection
0.656 0.344 0.000
T80.6 Other serum reactions
0.656 0.344 0.000
T80.5 Anaphylactic shock due to serum
0.656 0.344 0.000
T80.4 Rh incompatibility reaction
0.656 0.344 0.000
T80.3 ABO incompatibility reaction
0.656 0.344 0.000
T80.0 Air embolism following infusion, transfusion and therapeutic injection
0.656 0.344 0.000
D86 Sarcoidosis
0.655 0.345 0.000
S90.8 Other superficial injuries of ankle and foot
0.655 0.345 0.000
D68.9 Coagulation defect, unspecified
0.655 0.345 0.000
M31.6 Other giant cell arteritis
0.655 0.345 0.000
I45.2 Bifascicular block
0.654 0.346 0.000
S62.5 Fracture of thumb
0.654 0.346 0.000
S62.8 Fracture of other and unspecified parts of wrist and hand
0.654 0.346 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.654 0.346 0.000
M32 Systemic lupus erythematosus
0.654 0.346 0.000
T65 Toxic effect of other and unspecified substances
0.653 0.347 0.000
T62 Toxic effect of other noxious substances eaten as food
0.653 0.347 0.000
T61 Toxic effect of noxious substances eaten as seafood
0.653 0.347 0.000
T60 Toxic effect of pesticides
0.653 0.347 0.000
T59 Toxic effect of other gases, fumes and vapours
0.653 0.347 0.000
T57 Toxic effect of other inorganic substances
0.653 0.347 0.000
T56 Toxic effect of metals
0.653 0.347 0.000
T54 Toxic effect of corrosive substances
0.653 0.347 0.000
T53 Toxic effect of halogen derivatives of aliphatic and aromatic hydrocarbone
0.653 0.347 0.000
T52 Toxic effect of organic solvents
0.653 0.347 0.000
T64 Toxic effect of aflatoxin and other mycotoxin food contaminants
0.653 0.347 0.000
T58 Toxic effect of carbon monoxide
0.653 0.347 0.000
T55 Toxic effect of soaps and detergents
0.653 0.347 0.000
I72.8 Aneurysm of other specified arteries
0.652 0.348 0.000
M75.9 Shoulder lesion, unspecified
0.651 0.348 0.000
T51.9 Alcohol, unspecified
0.650 0.349 0.000
T21 Burn and corrosion of trunk
0.650 0.350 0.000
M21.16 Varus deformity, not elsewhere classified (Lower leg)
0.649 0.351 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.648 0.352 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.648 0.352 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.647 0.353 0.000
F30-F39 Mood [affective] disorders
0.646 0.354 0.000
M10.98 Gout, unspecified (Other)
0.645 0.355 0.000
M10.95 Gout, unspecified (Pelvic region and thigh)
0.645 0.355 0.000
M10.93 Gout, unspecified (Forearm)
0.645 0.355 0.000
M10.92 Gout, unspecified (Upper arm)
0.645 0.355 0.000
M10.91 Gout, unspecified (Shoulder region)
0.645 0.355 0.000
M10.90 Gout, unspecified (Multiple sites)
0.645 0.355 0.000
S20-S29 Injuries to the thorax
0.645 0.355 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.645 0.355 0.000
D55-D59 Haemolytic anaemias
0.644 0.355 0.000
M70.4 Prepatellar bursitis
0.644 0.356 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.643 0.357 0.000
S99 Other and unspecified injuries of ankle and foot
0.643 0.357 0.000
I72.4 Aneurysm of artery of lower extremity
0.642 0.358 0.000
T79.3 Post-traumatic wound infection, not elsewhere classified
0.642 0.358 0.000
M10.96 Gout, unspecified (Lower leg)
0.641 0.359 0.000
T23 Burn and corrosion of wrist and hand
0.641 0.359 0.000
M21.2 Flexion deformity
0.641 0.359 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.640 0.360 0.000
T22 Burn and corrosion of shoulder and upper limb, except wrist and hand
0.640 0.360 0.000
Q80-Q89 Other congenital malformations
0.638 0.362 0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.638 0.362 0.000
I46 Cardiac arrest
0.638 0.362 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.638 0.362 0.000
Q60-Q64 Congenital malformations of the urinary system
0.637 0.362 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.637 0.363 0.000
S98 Traumatic amputation of ankle and foot
0.637 0.363 0.000
S97 Crushing injury of ankle and foot
0.637 0.363 0.000
S96 Injury of muscle and tendon at ankle and foot level
0.637 0.363 0.000
S95 Injury of blood vessels at ankle and foot level
0.637 0.363 0.000
S94 Injury of nerves at ankle and foot level
0.637 0.363 0.000
I25 Chronic ischaemic heart disease
0.634 0.366 0.000
I70 Atherosclerosis
0.634 0.366 0.000
D63.0 Anaemia in neoplastic disease
0.632 0.368 0.000
T43.9 Psychotropic drug, unspecified
0.631 0.369 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.631 0.369 0.000
T43.6 Psychostimulants with abuse potential
0.631 0.369 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.631 0.369 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.631 0.369 0.000
M33.1 Other dermatomyositis
0.630 0.370 0.000
M42 Spinal osteochondrosis
0.630 0.370 0.000
M40 Kyphosis and lordosis
0.630 0.370 0.000
F80-F89 Disorders of psychological development
0.630 0.370 0.000
T88.9 Complication of surgical and medical care, unspecified
0.629 0.371 0.000
T88.3 Malignant hyperthermia due to anaesthesis
0.629 0.371 0.000
T88.2 Shock due to anaesthesia
0.629 0.371 0.000
T88.1 Other complications following immunisation, not elsewhere classified
0.629 0.371 0.000
T88.0 Infection following immunisation
0.629 0.371 0.000
I47.0 Reentry ventricular arrhythmia
0.629 0.371 0.000
S65 Injury of blood vessels at wrist and hand level
0.627 0.373 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.627 0.373 0.000
V20-V29 Motorcycle rider injured in transport accident
0.626 0.373 0.000
M71 Other bursopathies
0.626 0.373 0.000
I25.2 Old myocardial infarction
0.626 0.374 0.000
D68.4 Acquired coagulation factor deficiency
0.624 0.376 0.000
D68.1 Hereditary factor XI deficiency
0.624 0.376 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.623 0.377 0.000
I77.6 Arteritis, unspecified
0.623 0.377 0.000
X23 Contact with hornets, wasps and bees
0.622 0.377 0.000
M88 Paget's disease of bone [osteitis deformans]
0.620 0.380 0.000
I30.8 Other forms of acute pericarditis
0.619 0.381 0.000
I30.1 Infective pericarditis
0.619 0.381 0.000
I30.0 Acute nonspecific idiopathic pericarditis
0.619 0.381 0.000
A80-A89 Viral infections of the central nervous system
0.619 0.381 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.619 0.381 0.000
M75.8 Other shoulder lesions
0.619 0.381 0.000
S19 Other and unspecified injuries of neck
0.618 0.381 0.000
M24.9 Joint derangement, unspecified
0.618 0.382 0.000
M24.7 Protrusio acetabuli
0.618 0.382 0.000
M24.6 Ankylosis of joint
0.618 0.382 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.618 0.382 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.617 0.382 0.000
M03 Postinfective and reactive arthropathies in diseases classified elsewhere
0.616 0.384 0.000
M02 Reactive arthropathies
0.616 0.384 0.000
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere
0.616 0.384 0.000
M19.95 Arthrosis, unspecified (Pelvic region and thigh)
0.616 0.384 0.000
M21.67 Other acquired deformities of ankle and foot-Ankle/foot
0.615 0.384 0.000
T88.6 Anaphylactic shock due to adverse effect of correct drug or medicament properly administered
0.615 0.385 0.000
T86.9 Failure and rejection of unspecified transplanted organ and tissue
0.614 0.386 0.000
T86.4 Liver transplant failure and rejection
0.614 0.386 0.000
T86.3 Heart-lung transplant failure and rejection
0.614 0.386 0.000
T86.2 Heart transplant failure and rejection
0.614 0.386 0.000
S67 Crushing injury of wrist and hand
0.613 0.387 0.000
T25 Burn and corrosion of ankle and foot
0.613 0.387 0.000
T24 Burn and corrosion of hip and lower limb, except ankle and foot
0.613 0.387 0.000
M11 Other crystal arthropathies
0.612 0.388 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.612 0.388 0.000
Q35-Q37 Cleft lip and cleft palate
0.612 0.388 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.612 0.388 0.000
Q50-Q56 Congenital malformations of genital organs
0.612 0.388 0.000
I35 Nonrheumatic aortic valve disorders
0.612 0.388 0.000
M24.11 Other articular cartilage disorders (Shoulder region)
0.611 0.389 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.610 0.390 0.000
M76 Enthesopathies of lower limb, excluding foot
0.610 0.390 0.000
I72.6 Aneurysm and dissection of vertebral artery
0.609 0.391 0.000
I72.5 Aneurysm and dissection of other precerebral arteries
0.609 0.391 0.000
I72.2 Aneurysm of renal artery
0.609 0.391 0.000
I72.1 Aneurysm of artery of upper extremity
0.609 0.391 0.000
I74.8 Embolism and thrombosis of other arteries
0.608 0.392 0.000
M35 Other systemic involvement of connective tissue
0.607 0.393 0.000
V10-V19 Pedal cyclist injured in transport accident
0.607 0.393 0.000
I72.0 Aneurysm of carotid artery
0.606 0.394 0.000
M24.17 Other articular cartilage disorders (Ankle and foot)
0.605 0.395 0.000
M43.17 Spondylolisthesis (Lumbosacral region)
0.605 0.395 0.000
M19.27 Other secondary arthrosis (Ankle and foot)
0.605 0.395 0.000
W22 Striking against or struck by other objects
0.604 0.396 0.000
Y40.7 Antifungal antibiotics, systemically used
0.603 0.397 0.000
Y40.6 Rifamycins
0.603 0.397 0.000
Y40.5 Aminoglycosides
0.603 0.397 0.000
Y40.4 Tetracyclines
0.603 0.397 0.000
Y40.2 Chloramphenicol group
0.603 0.397 0.000
S17 Crushing injury of neck
0.603 0.397 0.000
S15 Injury of blood vessels at neck level
0.603 0.397 0.000
S14 Injury of nerves and spinal cord at neck level
0.603 0.397 0.000
S11 Open wound of neck
0.603 0.397 0.000
S18 Traumatic amputation at neck level
0.603 0.397 0.000
S16 Injury of muscle and tendon at neck level
0.603 0.397 0.000
T91 Sequelae of injuries of neck and trunk
0.602 0.398 0.000
X59 Exposure to unspecified factor
0.601 0.399 0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.601 0.399 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.601 0.399 0.000
T42.5 Mixed antiepileptics, not elsewhere classified
0.601 0.399 0.000
T42.3 Barbiturates
0.601 0.399 0.000
T42.2 Succinimides and oxazolidinediones
0.601 0.399 0.000
T42.1 Iminostilbenes
0.601 0.399 0.000
T42.0 Hydantoin derivatives
0.601 0.399 0.000
T50.8 Diagnostic agents
0.601 0.399 0.000
T50.7 Analeptics and opioid receptor antagonists
0.601 0.399 0.000
T50.6 Antidotes and chelating agents, not elsewhere classified
0.601 0.399 0.000
T50.5 Appetite depressants
0.601 0.399 0.000
T50.4 Drugs affecting uric acid metabolism
0.601 0.399 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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