TreeWAS – Variant ID: rs12304534

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability
Chapter IX Diseases of the circulatory system	1.000	0.000
I25 Chronic ischaemic heart disease	1.000	0.000
I20-I25 Ischaemic heart diseases	1.000	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	1.000	0.000
# Top node	1.000	0.000
I30-I52 Other forms of heart disease	0.999	0.001
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.999	0.001
M05-M14 Inflammatory polyarthropathies	0.999	0.001
M06 Other rheumatoid arthritis	0.998	0.002
M06.9 Rheumatoid arthritis, unspecified	0.998	0.002
I25.9 Chronic ischaemic heart disease, unspecified	0.998	0.002
I70-I79 Diseases of arteries, arterioles and capillaries	0.997	0.003
S60-S69 Injuries to the wrist and hand	0.993	0.007
I25.2 Old myocardial infarction	0.990	0.010
S61 Open wound of wrist and hand	0.988	0.012
M20-M25 Other joint disorders	0.983	0.017
I35 Nonrheumatic aortic valve disorders	0.982	0.018
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.979	0.021
I73 Other peripheral vascular diseases	0.978	0.022
M25 Other joint disorders, not elsewhere classified	0.977	0.023
I26 Pulmonary embolism	0.972	0.028
I26.9 Pulmonary embolism without mention of acute cor pulmonale	0.967	0.033
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.967	0.033
I74 Arterial embolism and thrombosis	0.953	0.047
I73.9 Peripheral vascular disease, unspecified	0.948	0.052
M25.4 Effusion of joint	0.943	0.057
S61.9 Open wound of wrist and hand, part unspecified	0.940	0.060
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.933	0.067
S20-S29 Injuries to the thorax	0.932	0.068
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.927	0.073
Chapter XX External causes of morbidity and mortality	0.927	0.073
S61.8 Open wound of other parts of wrist and hand	0.923	0.077
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.922	0.078
I47 Paroxysmal tachycardia	0.921	0.079
M25.5 Pain in joint	0.916	0.084
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.914	0.086
I74.3 Embolism and thrombosis of arteries of the lower extremities	0.914	0.086
I31 Other diseases of pericardium	0.906	0.094
I25.8 Other forms of chronic ischaemic heart disease	0.904	0.096
M25.46 Effusion of joint (Lower leg)	0.901	0.099
I35.2 Aortic (valve) stenosis with insufficiency	0.895	0.105
S22 Fracture of rib(s), sternum and thoracic spine	0.894	0.106
M25.56 Pain in joint (Lower leg)	0.891	0.109
I47.1 Supraventricular tachycardia	0.891	0.109
S61.0 Open wound of finger(s) without damage to nail	0.891	0.109
I71 Aortic aneurysm and dissection	0.885	0.115
I50 Heart failure	0.876	0.124
I35.0 Aortic (valve) stenosis	0.874	0.126
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.874	0.126
I30 Acute pericarditis	0.871	0.129
I24 Other acute ischaemic heart diseases	0.866	0.134
Chapter XII Diseases of the skin and subcutaneous tissue	0.863	0.137
I51 Complications and ill-defined descriptions of heart disease	0.860	0.140
W20-W49 Exposure to inanimate mechanical forces	0.856	0.144
M21 Other acquired deformities of limbs	0.855	0.145
I25.5 Ischaemic cardiomyopathy	0.854	0.146
S50-S59 Injuries to the elbow and forearm	0.850	0.150
T93 Sequelae of injuries of lower limb	0.848	0.152
I73.0 Raynaud's syndrome	0.846	0.154
I31.9 Disease of pericardium, unspecified	0.844	0.156
T20-T25 Burns and corrosions of external body surface, specified by site	0.842	0.158
I22 Subsequent myocardial infarction	0.831	0.169
M60-M63 Disorders of muscles	0.825	0.175
S62 Fracture at wrist and hand level	0.823	0.177
I35.9 Aortic valve disorder, unspecified	0.821	0.179
M31 Other necrotising vasculopathies	0.820	0.180
M86-M90 Other osteopathies	0.815	0.185
I49 Other cardiac arrhythmias	0.813	0.187
L20-L30 Dermatitis and eczema	0.812	0.188
M06.0 Seronegative rheumatoid arthritis	0.811	0.189
M00-M03 Infectious arthropathies	0.809	0.191
Y60-Y69 Misadventures to patients during surgical and medical care	0.807	0.193
I25.3 Aneurysm of heart	0.807	0.193
I50.9 Heart failure, unspecified	0.805	0.195
M45-M49 Spondylopathies	0.805	0.195
S22.3 Fracture of rib	0.803	0.197
M34 Systemic sclerosis	0.803	0.197
I35.1 Aortic (valve) insufficiency	0.800	0.200
I71.2 Thoracic aortic aneurysm, without mention of rupture	0.799	0.201
M50-M54 Other dorsopathies	0.798	0.202
S00-S09 Injuries to the head	0.797	0.203
I46 Cardiac arrest	0.792	0.208
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.792	0.208
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.792	0.208
M25.3 Other instability of joint	0.791	0.209
M25.0 Haemarthrosis	0.789	0.211
M07 Psoriatic and enteropathic arthropathies	0.787	0.213
M91-M94 Chondropathies	0.786	0.214
S22.0 Fracture of thoracic vertebra	0.782	0.218
I30.9 Acute pericarditis, unspecified	0.780	0.220
S10-S19 Injuries to the neck	0.779	0.221
M33 Dermatopolymyositis	0.777	0.223
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level	0.777	0.223
W25 Contact with sharp glass	0.776	0.224
M25.45 Effusion of joint (Pelvic region and thigh)	0.774	0.226
S64 Injury of nerves at wrist and hand level	0.769	0.231
T93.3 Sequelae of dislocation, sprain and strain of lower limb	0.769	0.231
Chapter VIII Diseases of the ear and mastoid process	0.767	0.233
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.767	0.233
S70-S79 Injuries to the hip and thigh	0.763	0.237
M25.6 Stiffness of joint, not elsewhere classified	0.761	0.239
Chapter I Certain infectious and parasitic diseases	0.758	0.242
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.755	0.245
I72 Other aneurysm	0.752	0.248
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.752	0.248
V20-V29 Motorcycle rider injured in transport accident	0.750	0.250
M24 Other specific joint derangements	0.748	0.251
S61.7 Multiple open wounds of wrist and hand	0.740	0.260
S22.30 Fracture of rib (closed)	0.738	0.262
I74.9 Embolism and thrombosis of unspecified artery	0.735	0.265
L40-L45 Papulosquamous disorders	0.734	0.266
T98 Sequelae of other and unspecified effects of external causes	0.734	0.266
M21.7 Unequal limb length (acquired)	0.732	0.268
S90-S99 Injuries to the ankle and foot	0.732	0.268
L30 Other dermatitis	0.732	0.268
X60-X84 Intentional self-harm	0.730	0.270
L27 Dermatitis due to substances taken internally	0.729	0.271
I70 Atherosclerosis	0.729	0.271
M06.3 Rheumatoid nodule	0.728	0.272
M80-M85 Disorders of bone density and structure	0.727	0.273
Chapter XXII Codes for special purposes	0.724	0.276
W50-W64 Exposure to animate mechanical forces	0.723	0.277
Y60 Unintentional cut, puncture, perforation or haemorrhage during surgical and medical care	0.722	0.278
S66 Injury of muscle and tendon at wrist and hand level	0.720	0.280
V40-V49 Car occupant injured in transport accident	0.720	0.280
I24.8 Other forms of acute ischaemic heart disease	0.720	0.280
W25.9 Unspecified place	0.719	0.281
M65-M68 Disorders of synovium and tendon	0.718	0.282
I00-I02 Acute rheumatic fever	0.717	0.283
I25.6 Silent myocardial ischaemia	0.717	0.283
I25.4 Coronary artery aneurysm	0.717	0.283
I25.0 Atherosclerotic cardiovascular disease, so described	0.717	0.283
I23 Certain current complications following acute myocardial infarction	0.717	0.283
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283
I52 Other heart disorders in diseases classified elsewhere	0.716	0.284
I48 Atrial fibrillation and flutter	0.716	0.284
I43 Cardiomyopathy in diseases classified elsewhere	0.716	0.284
I41 Myocarditis in diseases classified elsewhere	0.716	0.284
I40 Acute myocarditis	0.716	0.284
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.716	0.284
I37 Pulmonary valve disorders	0.716	0.284
I36 Nonrheumatic tricuspid valve disorders	0.716	0.284
I32 Pericarditis in diseases classified elsewhere	0.716	0.284
T33-T35 Frostbite	0.716	0.284
T26-T28 Burns and corrosions confined to eye and internal organs	0.716	0.284
T00-T07 Injuries involving multiple body regions	0.716	0.284
M14 Arthropathies in other diseases classified elsewhere	0.716	0.284
M12 Other specific arthropathies	0.716	0.284
M09 Juvenile arthritis in diseases classified elsewhere	0.716	0.284
M08 Juvenile arthritis	0.716	0.284
Y85-Y89 Sequelae of external causes of morbidity and mortality	0.716	0.284
M06.8 Other specified rheumatoid arthritis	0.716	0.284
M06.4 Inflammatory polyarthropathy	0.716	0.284
M06.2 Rheumatoid bursitis	0.716	0.284
M06.1 Adult-onset Still's disease	0.716	0.284
M06.98 Rheumatoid arthritis, unspecified (Other)	0.716	0.284
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.715	0.285
M31.6 Other giant cell arteritis	0.713	0.287
S22.1 Multiple fractures of thoracic spine	0.713	0.287
Chapter XI Diseases of the digestive system	0.712	0.288
S65 Injury of blood vessels at wrist and hand level	0.712	0.288
M25.8 Other specified joint disorders	0.710	0.290
T93.2 Sequelae of other fractures of lower limb	0.710	0.290
I35.8 Other aortic valve disorders	0.710	0.290
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.709	0.291
M25.47 Effusion of joint (Ankle and foot)	0.708	0.292
K80-K87 Disorders of gallbladder, biliary tract and pancreas	0.707	0.293
L50-L54 Urticaria and erythema	0.706	0.294
I33 Acute and subacute endocarditis	0.705	0.295
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.705	0.295
M32 Systemic lupus erythematosus	0.705	0.295
M30 Polyarteritis nodosa and related conditions	0.705	0.295
S00 Superficial injury of head	0.702	0.298
I28 Other diseases of pulmonary vessels	0.702	0.298
S22.00 Fracture of thoracic vertebra (closed)	0.701	0.299
I73.8 Other specified peripheral vascular diseases	0.701	0.299
I73.1 Thromboangiitis obliterans [Buerger]	0.701	0.299
M25.9 Joint disorder, unspecified	0.700	0.300
M25.2 Flail joint	0.700	0.300
M25.1 Fistula of joint	0.700	0.300
M62 Other disorders of muscle	0.699	0.301
I26.0 Pulmonary embolism with mention of acute cor pulmonale	0.697	0.303
K80 Cholelithiasis	0.697	0.303
K65-K67 Diseases of peritoneum	0.695	0.305
T23 Burn and corrosion of wrist and hand	0.695	0.305
I71.9 Aortic aneurysm of unspecified site, without mention of rupture	0.693	0.307
S67 Crushing injury of wrist and hand	0.693	0.307
I51.4 Myocarditis, unspecified	0.691	0.309
K80.5 Calculus of bile duct without cholangitis or cholecystitis	0.691	0.309
I49.9 Cardiac arrhythmia, unspecified	0.690	0.310
I51.3 Intracardiac thrombosis, not elsewhere classified	0.690	0.310
S61.1 Open wound of finger(s) with damage to nail	0.690	0.310
I74.2 Embolism and thrombosis of arteries of the upper extremities	0.689	0.310
M11 Other crystal arthropathies	0.688	0.312
I22.9 Subsequent myocardial infarction of unspecified site	0.687	0.313
T36-T50 Poisoning by drugs, medicaments and biological substances	0.686	0.314
T91 Sequelae of injuries of neck and trunk	0.686	0.314
M21.0 Valgus deformity, not elsewhere classified	0.686	0.314
M25.54 Pain in joint (Hand)	0.685	0.315
M47 Spondylosis	0.684	0.316
I74.8 Embolism and thrombosis of other arteries	0.683	0.317
I74.4 Embolism and thrombosis of arteries of extremities, unspecified	0.683	0.317
I74.1 Embolism and thrombosis of other and unspecified parts of aorta	0.683	0.317
I74.0 Embolism and thrombosis of abdominal aorta	0.683	0.317
M25.53 Pain in joint (Forearm)	0.683	0.317
M87 Osteonecrosis	0.683	0.317
T15-T19 Effects of foreign body entering through natural orifice	0.682	0.318
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.682	0.318
S69 Other and unspecified injuries of wrist and hand	0.682	0.318
K66 Other disorders of peritoneum	0.681	0.319
M25.51 Pain in joint (Shoulder region)	0.681	0.319
M50 Cervical disk disorders	0.680	0.320
I74.5 Embolism and thrombosis of iliac artery	0.680	0.320
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.678	0.322
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.678	0.322
S62.5 Fracture of thumb	0.678	0.322
S22.4 Multiple fractures of ribs	0.677	0.323
M25.49 Effusion of joint (Site unspecified)	0.676	0.324
M25.48 Effusion of joint (Other)	0.676	0.324
M25.44 Effusion of joint (Hand)	0.676	0.324
M25.43 Effusion of joint (Forearm)	0.676	0.324
M25.42 Effusion of joint (Upper arm)	0.676	0.324
M25.41 Effusion of joint (Shoulder region)	0.676	0.324
M25.40 Effusion of joint (Multiple sites)	0.676	0.324
X40-X49 Accidental poisoning by and exposure to noxious substances	0.676	0.324
S51 Open wound of forearm	0.676	0.324
L40 Psoriasis	0.675	0.325
L30.9 Dermatitis, unspecified	0.674	0.326
M34.9 Systemic sclerosis, unspecified	0.673	0.327
K83 Other diseases of biliary tract	0.673	0.327
M00 Pyogenic arthritis	0.672	0.328
L27.0 Generalised skin eruption due to drugs and medicaments	0.670	0.330
I47.0 Reentry ventricular arrhythmia	0.670	0.330
I51.7 Cardiomegaly	0.668	0.332
S28 Crushing injury of thorax and traumatic amputation of part of thorax	0.668	0.332
S26 Injury of heart	0.668	0.332
S25 Injury of blood vessels of thorax	0.668	0.332
S24 Injury of nerves and spinal cord at thorax level	0.668	0.332
S23 Dislocation, sprain and strain of joints and ligaments of thorax	0.668	0.332
S21 Open wound of thorax	0.668	0.332
K66.0 Peritoneal adhesions	0.667	0.333
M25.55 Pain in joint (Pelvic region and thigh)	0.666	0.334
M05 Seropositive rheumatoid arthritis	0.665	0.335
A30-A49 Other bacterial diseases	0.665	0.335
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.664	0.336
Y35-Y36 Legal intervention and operations of war	0.664	0.336
Y10-Y34 Event of undetermined intent	0.664	0.336
Y00-Y09 Assault	0.664	0.336
X85-X99 Assault	0.664	0.336
X58-X59 Accidental exposure to other and unspecified factors	0.664	0.336
X50-X57 Overexertion, travel and privation	0.664	0.336
X30-X39 Exposure to forces of nature	0.664	0.336
X10-X19 Contact with heat and hot substances	0.664	0.336
X00-X09 Exposure to smoke, fire and flames	0.664	0.336
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.664	0.336
W75-W84 Other accidental threats to breathing	0.664	0.336
W65-W74 Accidental drowning and submersion	0.664	0.336
V98-V99 Other and unspecified transport accidents	0.664	0.336
V95-V97 Air and space transport accidents	0.664	0.336
V90-V94 Water transport accidents	0.664	0.336
V70-V79 Bus occupant injured in transport accident	0.664	0.336
V60-V69 Occupant of heavy transport vehicle injured in transport accident	0.664	0.336
V50-V59 Occupant of pick-up truck or van injured in transport accident	0.664	0.336
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident	0.664	0.336
V01-V09 Pedestrian injured in transport accident	0.664	0.336
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.661	0.339
W20 Struck by thrown, projected or falling object	0.661	0.339
I49.1 Atrial premature depolarisation	0.661	0.339
T21 Burn and corrosion of trunk	0.659	0.341
S29 Other and unspecified injuries of thorax	0.659	0.341
M25.58 Pain in joint (Other)	0.657	0.343
M25.52 Pain in joint (Upper arm)	0.657	0.343
S70 Superficial injury of hip and thigh	0.657	0.343
I46.0 Cardiac arrest with successful resuscitation	0.657	0.343
W29 Contact with other powered hand tools and household machinery	0.656	0.343
T95 Sequelae of burns, corrosions and frostbite	0.655	0.344
T94 Sequelae of injuries involving multiple and unspecified body regions	0.655	0.344
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source	0.655	0.344
T96 Sequelae of poisoning by drugs, medicaments and biological substances	0.655	0.344
M25.06 Haemarthrosis (Lower leg)	0.655	0.345
S52 Fracture of forearm	0.653	0.347
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.653	0.347
S56 Injury of muscle and tendon at forearm level	0.651	0.349
I38 Endocarditis, valve unspecified	0.651	0.349
I31.8 Other specified diseases of pericardium	0.650	0.350
I31.2 Haemopericardium, not elsewhere classified	0.650	0.350
I31.1 Chronic constrictive pericarditis	0.650	0.350
I31.0 Chronic adhesive pericarditis	0.650	0.350
X20-X29 Contact with venomous animals and plants	0.648	0.352
M40-M43 Deforming dorsopathies	0.648	0.352
L40.5 Arthropathic psoriasis	0.646	0.354
Y60.0 During surgical operation	0.645	0.355
S62.4 Multiple fractures of metacarpal bones	0.644	0.355
M89 Other disorders of bone	0.644	0.355
M21.75 Unequal limb length (acquired) (Pelvic region and thigh)	0.645	0.355
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.644	0.356
S27 Injury of other and unspecified intrathoracic organs	0.643	0.357
M93 Other osteochondropathies	0.643	0.357
T79-T79 Certain early complications of trauma	0.642	0.358
S22.9 Fracture of bony thorax, part unspecified	0.641	0.359
S22.8 Fracture of other parts of bony thorax	0.641	0.359
S22.5 Flail chest	0.641	0.359
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.640	0.360
T92 Sequelae of injuries of upper limb	0.640	0.360
I22.8 Subsequent myocardial infarction of other sites	0.640	0.360
Y85 Sequelae of transport accidents	0.638	0.362
W22 Striking against or struck by other objects	0.638	0.362
M25.59 Pain in joint (Site unspecified)	0.638	0.362
I49.0 Ventricular fibrillation and flutter	0.637	0.363
S00.9 Superficial injury of head, part unspecified	0.637	0.363
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.636	0.364
I51.6 Cardiovascular disease, unspecified	0.636	0.364
T93.1 Sequelae of fracture of femur	0.635	0.364
M07.3 Other psoriatic arthropathies	0.635	0.365
H90-H95 Other disorders of ear	0.635	0.365
I71.8 Aortic aneurysm of unspecified site, ruptured	0.635	0.365
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture	0.635	0.365
I71.5 Thoracoabdominal aortic aneurysm, ruptured	0.635	0.365
I71.3 Abdominal aortic aneurysm, ruptured	0.635	0.365
I71.1 Thoracic aortic aneurysm, ruptured	0.635	0.365
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere	0.634	0.366
S20 Superficial injury of thorax	0.634	0.366
S50 Superficial injury of forearm	0.634	0.366
I50.0 Congestive heart failure	0.633	0.367
I31.3 Pericardial effusion (noninflammatory)	0.631	0.369
Q80-Q89 Other congenital malformations	0.630	0.370
I71.4 Abdominal aortic aneurysm, without mention of rupture	0.630	0.370
M33.1 Other dermatomyositis	0.629	0.371
M25.37 Other instability of joint (Ankle and foot)	0.629	0.371
Chapter VII Diseases of the eye and adnexa	0.629	0.371
I25.1 Atherosclerotic heart disease	0.628	0.372
V80-V89 Other land transport accidents	0.626	0.373
S60 Superficial injury of wrist and hand	0.626	0.373
L53 Other erythematous conditions	0.626	0.374
M21.3 Wrist or foot drop (acquired)	0.626	0.374
I05-I09 Chronic rheumatic heart diseases	0.626	0.374
I49.5 Sick sinus syndrome	0.625	0.375
I30.8 Other forms of acute pericarditis	0.625	0.375
I30.1 Infective pericarditis	0.625	0.375
I30.0 Acute nonspecific idiopathic pericarditis	0.625	0.375
I78 Diseases of capillaries	0.623	0.376
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.623	0.377
I51.8 Other ill-defined heart diseases	0.623	0.377
V23 Motorcycle rider injured in collision with car, pick-up truck or van	0.623	0.377
I24.1 Dressler's syndrome	0.621	0.379
I95-I99 Other and unspecified disorders of the circulatory system	0.621	0.379
K83.1 Obstruction of bile duct	0.620	0.380
W21 Striking against or struck by sports equipment	0.620	0.380
L10-L14 Bullous disorders	0.619	0.381
S62.2 Fracture of first metacarpal bone	0.618	0.382
I51.5 Myocardial degeneration	0.617	0.383
I51.2 Rupture of papillary muscle, not elsewhere classified	0.617	0.383
I51.1 Rupture of chordae tendineae, not elsewhere classified	0.617	0.383
I51.0 Cardiac septal defect, acquired	0.617	0.383
S22.2 Fracture of sternum	0.616	0.383
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.615	0.385
W49 Exposure to other and unspecified inanimate mechanical forces	0.614	0.386
W46 Contact with hypodermic needle	0.614	0.386
W45 Foreign body or object entering through skin	0.614	0.386
W43 Exposure to vibration	0.614	0.386
W42 Exposure to noise	0.614	0.386
W41 Exposure to high-pressure jet	0.614	0.386
W40 Explosion of other materials	0.614	0.386
W39 Discharge of firework	0.614	0.386
W38 Explosion and rupture of other specified pressurised devices	0.614	0.386
W37 Explosion and rupture of pressurised tyre, pipe or hose	0.614	0.386
W36 Explosion and rupture of gas cylinder	0.614	0.386
W35 Explosion and rupture of boiler	0.614	0.386
W34 Discharge from other and unspecified firearms	0.614	0.386
W33 Rifle, shotgun and larger firearm discharge	0.614	0.386
W32 Handgun discharge	0.614	0.386
W31 Contact with other and unspecified machinery	0.614	0.386
W30 Contact with agricultural machinery	0.614	0.386
W28 Contact with powered lawn mower	0.614	0.386
W27 Contact with nonpowered hand tool	0.614	0.386
W26 Contact with knife, sword or dagger	0.614	0.386
W24 Contact with lifting and transmission devices, not elsewhere classified	0.614	0.386
W23 Caught, crushed, jammed or pinched in or between objects	0.614	0.386
M21.9 Acquired deformity of limb, unspecified	0.613	0.387
M21.8 Other specified acquired deformities of limbs	0.613	0.387
M21.6 Other acquired deformities of ankle and foot	0.613	0.387
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.613	0.387
M21.4 Flat foot [pes planus] (acquired)	0.613	0.387
M21.2 Flexion deformity	0.613	0.387
Q50-Q56 Congenital malformations of genital organs	0.610	0.390
S59 Other and unspecified injuries of forearm	0.610	0.390
S58 Traumatic amputation of forearm	0.610	0.390
S57 Crushing injury of forearm	0.610	0.390
S55 Injury of blood vessels at forearm level	0.610	0.390
S54 Injury of nerves at forearm level	0.610	0.390
S53 Dislocation, sprain and strain of joints and ligaments of elbow	0.610	0.390
M62.8 Other specified disorders of muscle	0.609	0.391
T93.8 Sequelae of other specified injuries of lower limb	0.608	0.392
T93.6 Sequelae of crushing injury and traumatic amputation of lower limb	0.608	0.392
T93.5 Sequelae of injury of muscle and tendon of lower limb	0.608	0.392
T93.4 Sequelae of injury of nerve of lower limb	0.608	0.392
T93.0 Sequelae of open wound of lower limb	0.608	0.392
M25.31 Other instability of joint (Shoulder region)	0.607	0.392
S64.0 Injury of ulnar nerve at wrist and hand level	0.607	0.393
M35 Other systemic involvement of connective tissue	0.606	0.394
S63.6 Sprain and strain of finger(s)	0.604	0.396
T25 Burn and corrosion of ankle and foot	0.604	0.396
T24 Burn and corrosion of hip and lower limb, except ankle and foot	0.604	0.396
T22 Burn and corrosion of shoulder and upper limb, except wrist and hand	0.604	0.396
T20 Burn and corrosion of head and neck	0.604	0.396
S12 Fracture of neck	0.603	0.397
S02 Fracture of skull and facial bones	0.603	0.397
M84 Disorders of continuity of bone	0.603	0.397
Q20-Q28 Congenital malformations of the circulatory system	0.601	0.399
S62.6 Fracture of other finger	0.600	0.400
M90 Osteopathies in diseases classified elsewhere	0.600	0.400
L28 Lichen simplex chronicus and prurigo	0.598	0.401
S01 Open wound of head	0.598	0.402
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.597	0.403
A15-A19 Tuberculosis	0.596	0.404
I22.0 Subsequent myocardial infarction of anterior wall	0.596	0.404
K82 Other diseases of gallbladder	0.596	0.404
B15-B19 Viral hepatitis	0.595	0.405
I44 Atrioventricular and left bundle-branch block	0.595	0.405
T98.1 Sequelae of other and unspecified effects of external causes	0.594	0.406
M47.8 Other spondylosis	0.593	0.407
B00-B09 Viral infections characterized by skin and mucous membrane lesions	0.592	0.408
M63 Disorders of muscle in diseases classified elsewhere	0.591	0.409
M61 Calcification and ossification of muscle	0.591	0.409
M60 Myositis	0.591	0.409
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.591	0.409
M13 Other arthritis	0.591	0.409
W44 Foreign body entering into or through eye or natural orifice	0.590	0.409
S62.7 Multiple fractures of fingers	0.590	0.410
S62.1 Fracture of other carpal bone(s)	0.590	0.410
S62.0 Fracture of navicular [scaphoid] bone of hand	0.590	0.410
T23.2 Burn of second degree of wrist and hand	0.589	0.411
M24.4 Recurrent dislocation and subluxation of joint	0.589	0.411
I22.1 Subsequent myocardial infarction of inferior wall	0.589	0.411
M31.9 Necrotising vasculopathy, unspecified	0.588	0.412
M31.8 Other specified necrotising vasculopathies	0.588	0.412
M31.7 Microscopic polyangiitis	0.588	0.412
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.588	0.412
M31.4 Aortic arch syndrome [Takayasu]	0.588	0.412
M31.2 Lethal midline granuloma	0.588	0.412
M31.1 Thrombotic microangiopathy	0.588	0.412
M31.0 Hypersensitivity angiitis	0.588	0.412
I71.0 Dissection of aorta [any part]	0.586	0.414
S13 Dislocation, sprain and strain of joints and ligaments at neck level	0.585	0.415
M45 Ankylosing spondylitis	0.585	0.415
S22.10 Multiple fractures of thoracic spine (closed)	0.583	0.417
I49.2 Junctional premature depolarisation	0.583	0.417
S80-S89 Injuries to the knee and lower leg	0.582	0.418
L25 Unspecified contact dermatitis	0.582	0.418
L24 Irritant contact dermatitis	0.582	0.418
L23 Allergic contact dermatitis	0.582	0.418
L21 Seborrhoeic dermatitis	0.582	0.418
L20 Atopic dermatitis	0.582	0.418
L26 Exfoliative dermatitis	0.582	0.418
L22 Diaper [napkin] dermatitis	0.582	0.418
M06.08 Seronegative rheumatoid arthritis (Other)	0.581	0.419
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)	0.581	0.419
M06.06 Seronegative rheumatoid arthritis (Lower leg)	0.581	0.419
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)	0.581	0.419
M06.04 Seronegative rheumatoid arthritis (Hand)	0.581	0.419
M06.03 Seronegative rheumatoid arthritis (Forearm)	0.581	0.419
M06.02 Seronegative rheumatoid arthritis (Upper arm)	0.581	0.419
M06.01 Seronegative rheumatoid arthritis (Shoulder region)	0.581	0.419
T51 Toxic effect of alcohol	0.581	0.419
M21.1 Varus deformity, not elsewhere classified	0.581	0.419
H93 Other disorders of ear, not elsewhere classified	0.581	0.419
S63.4 Traumatic rupture of ligament of finger at metacarpophalangeal and interphalangeal joint(s)	0.580	0.420
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.580	0.420
M02 Reactive arthropathies	0.580	0.420
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.580	0.420
M25.88 Other specified joint disorders (Other)	0.579	0.421
Y65 Other misadventures during surgical and medical care	0.579	0.421
Y64 Contaminated medical or biological substances	0.579	0.421
Y63 Failure in dosage during surgical and medical care	0.579	0.421
Y62 Failure of sterile precautions during surgical and medical care	0.579	0.421
Y61 Foreign object accidentally left in body during surgical and medical care	0.579	0.421
Y69 Unspecified misadventure during surgical and medical care	0.579	0.421
Y66 Nonadministration of surgical and medical care	0.579	0.421
S62.8 Fracture of other and unspecified parts of wrist and hand	0.579	0.421
M10 Gout	0.578	0.422
M49 Spondylopathies in diseases classified elsewhere	0.577	0.423
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.577	0.423
W57 Bitten or stung by non-venomous insect and other non-venomous arthropods	0.577	0.423
K80.4 Calculus of bile duct with cholecystitis	0.577	0.423
A41 Other septicaemia	0.576	0.424
S22.31 Fracture of rib (open)	0.576	0.424
M34.8 Other forms of systemic sclerosis	0.575	0.424
M34.2 Systemic sclerosis induced by drugs and chemicals	0.575	0.424
M34.1 CR(E)ST syndrome	0.575	0.424
M34.0 Progressive systemic sclerosis	0.575	0.424
T31 Burns classified according to extent of body surface involved	0.575	0.425
M24.5 Contracture of joint	0.575	0.425
Y85.0 Sequelae of motor-vehicle accident	0.575	0.425
I72.8 Aneurysm of other specified arteries	0.575	0.425
M24.2 Disorder of ligament	0.575	0.425
S71 Open wound of hip and thigh	0.574	0.426
H80-H83 Diseases of inner ear	0.574	0.426
M00.9 Pyogenic arthritis, unspecified	0.574	0.426
S62.50 Fracture of thumb (closed)	0.574	0.426
I47.9 Paroxysmal tachycardia, unspecified	0.573	0.427

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations