TreeWAS – Variant ID: rs12412193

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
# Top node	1.000	0.000	0.000
Chapter VII Diseases of the eye and adnexa	1.000	0.000	0.000
Chapter IX Diseases of the circulatory system	1.000	0.000	0.000
I60-I69 Cerebrovascular diseases	0.999	0.001	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.997	0.003	0.000
E65-E68 Obesity and other hyperalimentation	0.997	0.003	0.000
E66.9 Obesity, unspecified	0.997	0.003	0.000
H30-H36 Disorders of choroid and retina	0.997	0.003	0.000
E66 Obesity	0.997	0.003	0.000
H33 Retinal detachments and breaks	0.994	0.006	0.000
I69 Sequelae of cerebrovascular disease	0.994	0.006	0.000
Chapter II Neoplasms	0.993	0.007	0.000
Chapter XX External causes of morbidity and mortality	0.992	0.008	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.990	0.010	0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction	0.989	0.011	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.988	0.012	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.987	0.013	0.000
H33.3 Retinal breaks without detachment	0.987	0.013	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.979	0.021	0.000
M80-M85 Disorders of bone density and structure	0.972	0.028	0.000
C15-C26 Malignant neoplasms of digestive organs	0.969	0.031	0.000
H40-H42 Glaucoma	0.966	0.034	0.000
M20-M25 Other joint disorders	0.966	0.034	0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.964	0.036	0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.962	0.038	0.000
S00-S09 Injuries to the head	0.960	0.040	0.000
I78 Diseases of capillaries	0.955	0.045	0.000
C15 Malignant neoplasm of oesophagus	0.954	0.046	0.000
S20-S29 Injuries to the thorax	0.953	0.047	0.000
M81 Osteoporosis without pathological fracture	0.952	0.048	0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.944	0.056	0.000
H40 Glaucoma	0.943	0.057	0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.941	0.059	0.000
M81.9 Osteoporosis, unspecified	0.939	0.061	0.000
I78.1 Naevus, nonneoplastic	0.938	0.062	0.000
H40.9 Glaucoma, unspecified	0.926	0.074	0.000
E20-E35 Disorders of other endocrine glands	0.925	0.075	0.000
S00 Superficial injury of head	0.920	0.080	0.000
M81.99 Osteoporosis, unspecified (Site unspecified)	0.919	0.081	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.915	0.085	0.000
H33.0 Retinal detachment with retinal break	0.912	0.088	0.000
Y45.0 Opioids and related analgesics	0.906	0.094	0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit	0.902	0.098	0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.899	0.101	0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.899	0.101	0.000
C71 Malignant neoplasm of brain	0.895	0.105	0.000
C16 Malignant neoplasm of stomach	0.894	0.106	0.000
Y51 Drugs primarily affecting the autonomic nervous system	0.892	0.108	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.887	0.113	0.000
M35 Other systemic involvement of connective tissue	0.885	0.115	0.000
C15.9 Oesophagus, unspecified	0.880	0.120	0.000
I61 Intracerebral haemorrhage	0.877	0.123	0.000
Y42.5 Other oestrogens and progestogens	0.874	0.126	0.000
I77 Other disorders of arteries and arterioles	0.872	0.128	0.000
C02 Malignant neoplasm of other and unspecified parts of tongue	0.868	0.132	0.000
I67 Other cerebrovascular diseases	0.868	0.132	0.000
Y42.7 Androgens and anabolic congeners	0.866	0.134	0.000
M25 Other joint disorders, not elsewhere classified	0.858	0.142	0.000
T20-T25 Burns and corrosions of external body surface, specified by site	0.856	0.144	0.000
M24 Other specific joint derangements	0.853	0.147	0.000
S00.8 Superficial injury of other parts of head	0.852	0.148	0.000
W00-W19 Falls	0.852	0.148	0.000
I64 Stroke, not specified as haemorrhage or infarction	0.851	0.149	0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.850	0.150	0.000
S22 Fracture of rib(s), sternum and thoracic spine	0.848	0.152	0.000
E65 Localised adiposity	0.847	0.153	0.000
H40.0 Glaucoma suspect	0.841	0.159	0.000
M85 Other disorders of bone density and structure	0.837	0.163	0.000
I63 Cerebral infarction	0.836	0.163	0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction	0.835	0.165	0.000
E22 Hyperfunction of pituitary gland	0.834	0.166	0.000
E66.2 Extreme obesity with alveolar hypoventilation	0.831	0.169	0.000
C15.5 Lower third of oesophagus	0.830	0.170	0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.828	0.172	0.000
S06 Intracranial injury	0.827	0.173	0.000
D00-D09 In situ neoplasms	0.826	0.174	0.000
M35.0 Sicca syndrome [Sjogren]	0.823	0.177	0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified	0.822	0.178	0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites	0.820	0.180	0.000
Y42.8 Other and unspecified hormones and their synthetic substitutes	0.819	0.181	0.000
S00.1 Contusion of eyelid and periocular area	0.818	0.182	0.000
I71 Aortic aneurysm and dissection	0.817	0.183	0.000
S27 Injury of other and unspecified intrathoracic organs	0.816	0.184	0.000
C15.3 Upper third of oesophagus	0.811	0.189	0.000
I26 Pulmonary embolism	0.807	0.193	0.000
H35 Other retinal disorders	0.806	0.194	0.000
H43-H45 Disorders of vitreous body and globe	0.804	0.196	0.000
S20 Superficial injury of thorax	0.803	0.197	0.000
I67.9 Cerebrovascular disease, unspecified	0.801	0.199	0.000
C17 Malignant neoplasm of small intestine	0.801	0.199	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.800	0.200	0.000
S90-S99 Injuries to the ankle and foot	0.799	0.201	0.000
H55-H59 Other disorders of eye and adnexa	0.799	0.201	0.000
M21 Other acquired deformities of limbs	0.798	0.202	0.000
M60-M63 Disorders of muscles	0.796	0.204	0.000
C15.4 Middle third of oesophagus	0.795	0.205	0.000
C01 Malignant neoplasm of base of tongue	0.795	0.205	0.000
E22.1 Hyperprolactinaemia	0.791	0.209	0.000
I69.0 Sequelae of subarachnoid haemorrhage	0.791	0.209	0.000
H05 Disorders of orbit	0.789	0.211	0.000
S10-S19 Injuries to the neck	0.789	0.211	0.000
C09 Malignant neoplasm of tonsil	0.788	0.212	0.000
S22.4 Multiple fractures of ribs	0.785	0.215	0.000
M00-M03 Infectious arthropathies	0.785	0.215	0.000
C23 Malignant neoplasm of gallbladder	0.784	0.216	0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.782	0.218	0.000
C71.9 Brain, unspecified	0.781	0.219	0.000
C16.0 Cardia	0.780	0.220	0.000
M91-M94 Chondropathies	0.780	0.220	0.000
M81.95 Osteoporosis, unspecified (Pelvic region and thigh)	0.779	0.221	0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.779	0.221	0.000
I77.6 Arteritis, unspecified	0.777	0.223	0.000
Y46 Antiepileptics and anti-Parkinsonism drugs	0.776	0.224	0.000
C16.9 Stomach, unspecified	0.774	0.226	0.000
S50-S59 Injuries to the elbow and forearm	0.774	0.226	0.000
N40-N51 Diseases of male genital organs	0.772	0.228	0.000
Chapter XIV Diseases of the genitourinary system	0.772	0.228	0.000
M25.5 Pain in joint	0.772	0.228	0.000
X58-X59 Accidental exposure to other and unspecified factors	0.771	0.229	0.000
X60-X84 Intentional self-harm	0.770	0.230	0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes	0.770	0.230	0.000
C10 Malignant neoplasm of oropharynx	0.769	0.231	0.000
D37-D48 Neoplasms of uncertain or unknown behaviour	0.769	0.231	0.000
H33.1 Retinoschisis and retinal cysts	0.769	0.231	0.000
X40-X49 Accidental poisoning by and exposure to noxious substances	0.767	0.233	0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs	0.766	0.234	0.000
H01 Other inflammation of eyelid	0.764	0.236	0.000
E21.0 Primary hyperparathyroidism	0.762	0.238	0.000
N47 Redundant prepuce, phimosis and paraphimosis	0.762	0.238	0.000
Y44 Agents primarily affecting blood constituents	0.762	0.238	0.000
H40.5 Glaucoma secondary to other eye disorders	0.761	0.239	0.000
M33 Dermatopolymyositis	0.760	0.240	0.000
H35.8 Other specified retinal disorders	0.760	0.240	0.000
I63.9 Cerebral infarction, unspecified	0.759	0.241	0.000
H10-H13 Disorders of conjunctiva	0.759	0.241	0.000
T92 Sequelae of injuries of upper limb	0.759	0.241	0.000
C02.9 Tongue, unspecified	0.758	0.242	0.000
M31 Other necrotising vasculopathies	0.756	0.244	0.000
S00.5 Superficial injury of lip and oral cavity	0.755	0.245	0.000
I62 Other nontraumatic intracranial haemorrhage	0.754	0.246	0.000
H53-H54 Visual disturbances and blindness	0.754	0.246	0.000
Y00-Y09 Assault	0.754	0.246	0.000
C78.0 Secondary malignant neoplasm of lung	0.754	0.246	0.000
S05 Injury of eye and orbit	0.752	0.248	0.000
H52 Disorders of refraction and accommodation	0.752	0.248	0.000
N42 Other disorders of prostate	0.752	0.248	0.000
I69.1 Sequelae of intracerebral haemorrhage	0.751	0.249	0.000
Y60-Y69 Misadventures to patients during surgical and medical care	0.751	0.249	0.000
M86-M90 Other osteopathies	0.751	0.249	0.000
H34 Retinal vascular occlusions	0.751	0.249	0.000
D04 Carcinoma in situ of skin	0.748	0.252	0.000
S30 Superficial injury of abdomen, lower back and pelvis	0.748	0.252	0.000
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.747	0.253	0.000
W17 Other fall from one level to another	0.747	0.253	0.000
S02 Fracture of skull and facial bones	0.747	0.253	0.000
I74 Arterial embolism and thrombosis	0.746	0.254	0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.742	0.257	0.000
I61.5 Intracerebral haemorrhage, intraventricular	0.740	0.259	0.000
I28 Other diseases of pulmonary vessels	0.740	0.260	0.000
S22.40 Multiple fractures of ribs (closed)	0.740	0.260	0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.739	0.261	0.000
E50-E64 Other nutritional deficiencies	0.738	0.262	0.000
S00.2 Other superficial injuries of eyelid and periocular area	0.737	0.263	0.000
I82 Other venous embolism and thrombosis	0.736	0.264	0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.735	0.265	0.000
C07 Malignant neoplasm of parotid gland	0.732	0.268	0.000
C64-C68 Malignant neoplasms of urinary tract	0.731	0.268	0.000
S40-S49 Injuries to the shoulder and upper arm	0.731	0.269	0.000
Y41 Other systemic anti-infectives and antiparasitics	0.731	0.269	0.000
I26.9 Pulmonary embolism without mention of acute cor pulmonale	0.730	0.270	0.000
S29 Other and unspecified injuries of thorax	0.730	0.270	0.000
C69 Malignant neoplasm of eye and adnexa	0.729	0.271	0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere	0.729	0.271	0.000
M32 Systemic lupus erythematosus	0.728	0.272	0.000
Q20-Q28 Congenital malformations of the circulatory system	0.727	0.273	0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.727	0.273	0.000
W50-W64 Exposure to animate mechanical forces	0.726	0.274	0.000
I87 Other disorders of veins	0.723	0.277	0.000
S37 Injury of urinary and pelvic organs	0.722	0.278	0.000
M25.51 Pain in joint (Shoulder region)	0.721	0.279	0.000
D07 Carcinoma in situ of other and unspecified genital organs	0.721	0.279	0.000
V80-V89 Other land transport accidents	0.720	0.280	0.000
Y42.0 Glucocorticoids and synthetic analogs	0.720	0.280	0.000
C02.1 Border of tongue	0.720	0.280	0.000
M82 Osteoporosis in diseases classified elsewhere	0.719	0.281	0.000
M81.98 Osteoporosis, unspecified (Other)	0.718	0.282	0.000
C71.0 Cerebrum, except lobes and ventricles	0.717	0.282	0.000
Chapter XXII Codes for special purposes	0.717	0.282	0.000
T79-T79 Certain early complications of trauma	0.717	0.283	0.000
C20 Malignant neoplasm of rectum	0.717	0.283	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283	0.000
E27 Other disorders of adrenal gland	0.717	0.283	0.000
I00-I02 Acute rheumatic fever	0.717	0.283	0.000
I89.0 Lymphoedema, not elsewhere classified	0.717	0.283	0.000
S32 Fracture of lumbar spine and pelvis	0.716	0.284	0.000
I68 Cerebrovascular disorders in diseases classified elsewhere	0.716	0.284	0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction	0.716	0.284	0.000
E67 Other hyperalimentation	0.715	0.285	0.000
E68 Sequelae of hyperalimentation	0.715	0.285	0.000
H32 Chorioretinal disorders in diseases classified elsewhere	0.715	0.285	0.000
H31 Other disorders of choroid	0.715	0.285	0.000
H30 Chorioretinal inflammation	0.715	0.285	0.000
E66.1 Drug-induced obesity	0.715	0.285	0.000
E66.0 Obesity due to excess calories	0.715	0.285	0.000
H33.4 Traction detachment of retina	0.713	0.287	0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases	0.713	0.287	0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage	0.713	0.287	0.000
I77.8 Other specified disorders of arteries and arterioles	0.712	0.287	0.000
C40-C41 Malignant neoplasms of bone and articular cartilage	0.712	0.288	0.000
C71.3 Parietal lobe	0.712	0.288	0.000
Y35-Y36 Legal intervention and operations of war	0.712	0.288	0.000
Y10-Y34 Event of undetermined intent	0.712	0.288	0.000
X85-X99 Assault	0.712	0.288	0.000
X50-X57 Overexertion, travel and privation	0.712	0.288	0.000
X30-X39 Exposure to forces of nature	0.712	0.288	0.000
X10-X19 Contact with heat and hot substances	0.712	0.288	0.000
X00-X09 Exposure to smoke, fire and flames	0.712	0.288	0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.712	0.288	0.000
W75-W84 Other accidental threats to breathing	0.712	0.288	0.000
W65-W74 Accidental drowning and submersion	0.712	0.288	0.000
V98-V99 Other and unspecified transport accidents	0.712	0.288	0.000
V95-V97 Air and space transport accidents	0.712	0.288	0.000
V90-V94 Water transport accidents	0.712	0.288	0.000
V70-V79 Bus occupant injured in transport accident	0.712	0.288	0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident	0.712	0.288	0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident	0.712	0.288	0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident	0.712	0.288	0.000
V01-V09 Pedestrian injured in transport accident	0.712	0.288	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.711	0.289	0.000
C71.8 Overlapping lesion of brain	0.711	0.289	0.000
Y48 Anaesthetics and therapeutic gases	0.710	0.290	0.000
C51-C58 Malignant neoplasms of female genital organs	0.710	0.290	0.000
Y59 Other and unspecified vaccines and biological substances	0.710	0.290	0.000
Y58 Bacterial vaccines	0.710	0.290	0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.710	0.290	0.000
Y53 Agents primarily affecting the gastro-intestinal system	0.710	0.290	0.000
Y50 Central nervous system stimulants, not elsewhere classified	0.710	0.290	0.000
Y49 Psychotropic drugs, not elsewhere classified	0.710	0.290	0.000
Y47 Sedatives, hypnotics and antianxiety drugs	0.710	0.290	0.000
E34 Other endocrine disorders	0.709	0.291	0.000
V40-V49 Car occupant injured in transport accident	0.709	0.291	0.000
T33-T35 Frostbite	0.708	0.292	0.000
T26-T28 Burns and corrosions confined to eye and internal organs	0.708	0.292	0.000
T00-T07 Injuries involving multiple body regions	0.708	0.292	0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.707	0.293	0.000
M81.90 Osteoporosis, unspecified (Multiple sites)	0.707	0.293	0.000
I63.4 Cerebral infarction due to embolism of cerebral arteries	0.705	0.295	0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.705	0.295	0.000
X20-X29 Contact with venomous animals and plants	0.704	0.295	0.000
C71.2 Temporal lobe	0.704	0.296	0.000
M35.7 Hypermobility syndrome	0.703	0.296	0.000
M84 Disorders of continuity of bone	0.703	0.297	0.000
V10-V19 Pedal cyclist injured in transport accident	0.703	0.297	0.000
M23 Internal derangement of knee	0.702	0.298	0.000
C80 Malignant neoplasm without specification of site	0.702	0.298	0.000
I27 Other pulmonary heart diseases	0.700	0.300	0.000
M70-M79 Other soft tissue disorders	0.698	0.302	0.000
N17-N19 Renal failure	0.698	0.302	0.000
M25.8 Other specified joint disorders	0.697	0.303	0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites	0.697	0.303	0.000
M83 Adult osteomalacia	0.697	0.303	0.000
H57 Other disorders of eye and adnexa	0.696	0.304	0.000
I67.2 Cerebral atherosclerosis	0.696	0.304	0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs	0.696	0.304	0.000
T23 Burn and corrosion of wrist and hand	0.695	0.305	0.000
Q80-Q89 Other congenital malformations	0.695	0.305	0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract	0.695	0.305	0.000
Chapter XV Pregnancy, childbirth and the puerperium	0.693	0.306	0.001
I78.0 Hereditary haemorrhagic telangiectasia	0.693	0.307	0.000
H42 Glaucoma in diseases classified elsewhere	0.693	0.307	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.693	0.307	0.000
M30 Polyarteritis nodosa and related conditions	0.693	0.307	0.000
I10-I15 Hypertensive diseases	0.693	0.307	0.000
Q60-Q64 Congenital malformations of the urinary system	0.692	0.307	0.000
Y42.9 Other and unspecified hormone antagonists	0.691	0.309	0.000
Y42.4 Oral contraceptives	0.691	0.309	0.000
Y42.2 Antithyroid drugs	0.691	0.309	0.000
Y42.1 Thyroid hormones and substitutes	0.691	0.309	0.000
H05.0 Acute inflammation of orbit	0.691	0.309	0.000
T24 Burn and corrosion of hip and lower limb, except ankle and foot	0.690	0.310	0.000
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx	0.690	0.310	0.000
C13 Malignant neoplasm of hypopharynx	0.690	0.310	0.000
C11 Malignant neoplasm of nasopharynx	0.690	0.310	0.000
C08 Malignant neoplasm of other and unspecified major salivary glands	0.690	0.310	0.000
C06 Malignant neoplasm of other and unspecified parts of mouth	0.690	0.310	0.000
C05 Malignant neoplasm of palate	0.690	0.310	0.000
C04 Malignant neoplasm of floor of mouth	0.690	0.310	0.000
C03 Malignant neoplasm of gum	0.690	0.310	0.000
C00 Malignant neoplasm of lip	0.690	0.310	0.000
C12 Malignant neoplasm of pyriform sinus	0.690	0.310	0.000
H04 Disorders of lachrymal system	0.690	0.310	0.000
N42.9 Disorder of prostate, unspecified	0.689	0.311	0.000
Chapter XII Diseases of the skin and subcutaneous tissue	0.689	0.311	0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.688	0.312	0.000
S08 Traumatic amputation of part of head	0.688	0.312	0.000
S07 Crushing injury of head	0.688	0.312	0.000
S04 Injury of cranial nerves	0.688	0.312	0.000
S03 Dislocation, sprain and strain of joints and ligaments of head	0.688	0.312	0.000
H35.4 Peripheral retinal degeneration	0.687	0.313	0.000
H40.8 Other glaucoma	0.686	0.314	0.000
S06.2 Diffuse brain injury	0.686	0.314	0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis	0.685	0.315	0.000
T98 Sequelae of other and unspecified effects of external causes	0.685	0.315	0.000
I78.9 Disease of capillaries, unspecified	0.685	0.315	0.000
I78.8 Other diseases of capillaries	0.685	0.315	0.000
I69.3 Sequelae of cerebral infarction	0.685	0.315	0.000
C15.8 Overlapping lesion of oesophagus	0.684	0.316	0.000
C15.2 Abdominal part of oesophagus	0.684	0.316	0.000
C15.1 Thoracic part of oesophagus	0.684	0.316	0.000
C15.0 Cervical part of oesophagus	0.684	0.316	0.000
Chapter VI Diseases of the nervous system	0.684	0.316	0.000
S28 Crushing injury of thorax and traumatic amputation of part of thorax	0.683	0.316	0.000
S26 Injury of heart	0.683	0.316	0.000
S25 Injury of blood vessels of thorax	0.683	0.316	0.000
S24 Injury of nerves and spinal cord at thorax level	0.683	0.316	0.000
S23 Dislocation, sprain and strain of joints and ligaments of thorax	0.683	0.316	0.000
S21 Open wound of thorax	0.683	0.316	0.000
M81.8 Other osteoporosis	0.682	0.318	0.000
M81.6 Localised osteoporosis [Lequesne]	0.682	0.318	0.000
M81.5 Idiopathic osteoporosis	0.682	0.318	0.000
M81.3 Postsurgical malabsorption osteoporosis	0.682	0.318	0.000
M81.2 Osteoporosis of disuse	0.682	0.318	0.000
M81.1 Postoophorectomy osteoporosis	0.682	0.318	0.000
M81.0 Postmenopausal osteoporosis	0.682	0.318	0.000
I61.1 Intracerebral haemorrhage in hemisphere, cortical	0.682	0.318	0.000
Y57 Other and unspecified drugs and medicaments	0.681	0.318	0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture	0.681	0.319	0.000
M24.5 Contracture of joint	0.681	0.319	0.000
M21.2 Flexion deformity	0.680	0.320	0.000
Y42.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.680	0.320	0.000
Y45.1 Salicylates	0.678	0.321	0.000
H33.2 Serous retinal detachment	0.678	0.322	0.000
S20.2 Contusion of thorax	0.678	0.322	0.000
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified	0.677	0.323	0.000
Y45.8 Other analgesics and antipyretics	0.677	0.323	0.000
Y45.5 4-Aminophenol derivatives	0.677	0.323	0.000
Y45.4 Antirheumatics	0.677	0.323	0.000
I70 Atherosclerosis	0.677	0.323	0.000
I61.9 Intracerebral haemorrhage, unspecified	0.676	0.324	0.000
H40.6 Glaucoma secondary to drugs	0.676	0.324	0.000
H40.4 Glaucoma secondary to eye inflammation	0.676	0.324	0.000
H40.3 Glaucoma secondary to eye trauma	0.676	0.324	0.000
W03 Other fall on same level due to collision with, or pushing by, another person	0.676	0.324	0.000
I67.1 Cerebral aneurysm, nonruptured	0.675	0.325	0.000
C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system	0.675	0.325	0.000
C70 Malignant neoplasm of meninges	0.675	0.325	0.000
M25.57 Pain in joint (Ankle and foot)	0.674	0.326	0.000
H33.5 Other retinal detachments	0.674	0.326	0.000
M81.97 Osteoporosis, unspecified (Ankle and foot)	0.673	0.326	0.000
M81.96 Osteoporosis, unspecified (Lower leg)	0.673	0.326	0.000
M81.94 Osteoporosis, unspecified (Hand)	0.673	0.326	0.000
M81.93 Osteoporosis, unspecified (Forearm)	0.673	0.326	0.000
M81.92 Osteoporosis, unspecified (Upper arm)	0.673	0.326	0.000
M81.91 Osteoporosis, unspecified (Shoulder region)	0.673	0.326	0.000
M25.6 Stiffness of joint, not elsewhere classified	0.673	0.327	0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.673	0.327	0.000
H01.0 Blepharitis	0.673	0.327	0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs	0.672	0.327	0.000
N48 Other disorders of penis	0.671	0.329	0.000
E20 Hypoparathyroidism	0.671	0.329	0.000
H15 Disorders of sclera	0.670	0.330	0.000
S06.4 Epidural haemorrhage	0.670	0.330	0.000
V20-V29 Motorcycle rider injured in transport accident	0.669	0.330	0.000
M85.6 Other cyst of bone	0.669	0.331	0.000
I05-I09 Chronic rheumatic heart diseases	0.667	0.333	0.000
T15-T19 Effects of foreign body entering through natural orifice	0.667	0.333	0.000
D00 Carcinoma in situ of oral cavity, oesophagus and stomach	0.666	0.334	0.000
S27.0 Traumatic pneumothorax	0.666	0.334	0.000
M85.8 Other specified disorders of bone density and structure	0.665	0.335	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.665	0.335	0.000
N42.8 Other specified disorders of prostate	0.664	0.336	0.000
C09.9 Tonsil, unspecified	0.664	0.336	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.663	0.337	0.000
E32 Diseases of thymus	0.663	0.337	0.000
E31 Polyglandular dysfunction	0.663	0.337	0.000
E30 Disorders of puberty, not elsewhere classified	0.663	0.337	0.000
E25 Adrenogenital disorders	0.663	0.337	0.000
C64 Malignant neoplasm of kidney, except renal pelvis	0.661	0.339	0.000
H44 Disorders of globe	0.661	0.339	0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.660	0.339	0.000
M31.3 Wegener's granulomatosis	0.660	0.340	0.000
I77.1 Stricture of artery	0.660	0.340	0.000
I80 Phlebitis and thrombophlebitis	0.660	0.340	0.000
S00.4 Superficial injury of ear	0.659	0.341	0.000
H52.2 Astigmatism	0.659	0.341	0.000
M62 Other disorders of muscle	0.658	0.342	0.000
H00 Hordeolum and chalazion	0.657	0.343	0.000
N43 Hydrocele and spermatocele	0.657	0.343	0.000
W13 Fall from, out of or through building or structure	0.656	0.344	0.000
I85 Oesophageal varices	0.654	0.345	0.000
M24.1 Other articular cartilage disorders	0.654	0.346	0.000
C17.9 Small intestine, unspecified	0.654	0.346	0.000
S06.8 Other intracranial injuries	0.654	0.346	0.000
C21 Malignant neoplasm of anus and anal canal	0.652	0.348	0.000
I88 Nonspecific lymphadenitis	0.651	0.349	0.000
H49 Paralytic strabismus	0.651	0.349	0.000
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified	0.650	0.350	0.000
T20 Burn and corrosion of head and neck	0.650	0.350	0.000
M05-M14 Inflammatory polyarthropathies	0.650	0.350	0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.649	0.350	0.000
M24.8 Other specific joint derangements, not elsewhere classified	0.649	0.351	0.000
I63.3 Cerebral infarction due to thrombosis of cerebral arteries	0.649	0.351	0.000
S01 Open wound of head	0.648	0.352	0.000
W10 Fall on and from stairs and steps	0.648	0.352	0.000
M85.0 Fibrous dysplasia (monostotic)	0.648	0.352	0.000
H03 Disorders of eyelid in diseases classified elsewhere	0.646	0.353	0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis	0.644	0.355	0.000
S36 Injury of intra-abdominal organs	0.644	0.355	0.000
S35 Injury of blood vessels at abdomen, lower back and pelvis level	0.644	0.355	0.000
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level	0.644	0.355	0.000
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis	0.644	0.355	0.000
S31 Open wound of abdomen, lower back and pelvis	0.644	0.355	0.000
E26 Hyperaldosteronism	0.644	0.355	0.000
H54 Blindness and low vision	0.644	0.356	0.000
Y40 Systemic antibiotics	0.643	0.356	0.001
I83 Varicose veins of lower extremities	0.643	0.357	0.000
S27.3 Other injuries of lung	0.643	0.357	0.000
I84 Haemorrhoids	0.642	0.358	0.000
M25.3 Other instability of joint	0.642	0.358	0.000
M24.0 Loose body in joint	0.642	0.358	0.000
M24.2 Disorder of ligament	0.641	0.358	0.000
C71.7 Brain stem	0.641	0.358	0.000
C71.6 Cerebellum	0.641	0.358	0.000
C71.5 Cerebral ventricle	0.641	0.358	0.000
C71.4 Occipital lobe	0.641	0.358	0.000
T66-T78 Other and unspecified effects of external causes	0.641	0.359	0.000
C16.8 Overlapping lesion of stomach	0.641	0.359	0.000
C16.6 Greater curvature of stomach, unspecified	0.641	0.359	0.000
C16.5 Lesser curvature of stomach, unspecified	0.641	0.359	0.000
C16.4 Pylorus	0.641	0.359	0.000
C16.3 Pyloric antrum	0.641	0.359	0.000
C16.2 Body of stomach	0.641	0.359	0.000
C16.1 Fundus of stomach	0.641	0.359	0.000
M25.0 Haemarthrosis	0.641	0.359	0.000
S13 Dislocation, sprain and strain of joints and ligaments at neck level	0.641	0.359	0.000
Y51.9 Other and unspecified drugs primarily affecting the autonomic nervous system	0.640	0.360	0.000
Y51.8 Centrally acting and adrenergic-neuron-blocking agents, not elsewhere classified	0.640	0.360	0.000
Y51.6 @-Adrenoreceptor antagonists, not elsewhere classified	0.640	0.360	0.000
Y51.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.640	0.360	0.000
Y51.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.640	0.360	0.000
Y51.3 Other parasympatholytics [anticholinergics and antimuscarinics] and spasmolytics, not elsewhere classified	0.640	0.360	0.000
Y51.2 Ganglionic blocking drugs, not elsewhere classified	0.640	0.360	0.000
Y51.1 Other parasympathomimetics [cholinergics]	0.640	0.360	0.000
Y51.0 Anticholinesterase agents	0.640	0.360	0.000
M00 Pyogenic arthritis	0.639	0.361	0.000
M24.4 Recurrent dislocation and subluxation of joint	0.639	0.361	0.000
C76 Malignant neoplasm of other and ill-defined sites	0.638	0.362	0.000
S02.1 Fracture of base of skull	0.638	0.362	0.000
S92 Fracture of foot, except ankle	0.637	0.363	0.000
I86 Varicose veins of other sites	0.636	0.364	0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.636	0.364	0.000
Q35-Q37 Cleft lip and cleft palate	0.636	0.364	0.000
Q30-Q34 Congenital malformations of the respiratory system	0.636	0.364	0.000
M35.9 Systemic involvement of connective tissue, unspecified	0.635	0.365	0.000
M35.8 Other specified systemic involvement of connective tissue	0.635	0.365	0.000
M35.6 Relapsing panniculitis [Weber-Christian]	0.635	0.365	0.000
M35.5 Multifocal fibrosclerosis	0.635	0.365	0.000
M35.4 Diffuse (eosinophilic) fasciitis	0.635	0.365	0.000
M35.2 Behcet's disease	0.635	0.365	0.000
M35.1 Other overlap syndromes	0.635	0.365	0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture	0.635	0.365	0.000
S50 Superficial injury of forearm	0.635	0.365	0.000
N49 Inflammatory disorders of male genital organs, not elsewhere classified	0.634	0.366	0.000
E28 Ovarian dysfunction	0.634	0.366	0.000
S00.9 Superficial injury of head, part unspecified	0.633	0.367	0.000
N17 Acute renal failure	0.632	0.368	0.000
C10.9 Oropharynx, unspecified	0.631	0.369	0.000
O34 Maternal care for known or suspected abnormality of pelvic organs	0.630	0.370	0.000
M81.4 Drug-induced osteoporosis	0.629	0.370	0.000
I61.8 Other intracerebral haemorrhage	0.629	0.371	0.000
I61.6 Intracerebral haemorrhage, multiple localised	0.629	0.371	0.000
I61.4 Intracerebral haemorrhage in cerebellum	0.629	0.371	0.000
I61.3 Intracerebral haemorrhage in brain stem	0.629	0.371	0.000
I61.2 Intracerebral haemorrhage in hemisphere, unspecified	0.629	0.371	0.000
I61.0 Intracerebral haemorrhage in hemisphere, subcortical	0.629	0.371	0.000
I60 Subarachnoid haemorrhage	0.629	0.371	0.000
M80 Osteoporosis with pathological fracture	0.629	0.371	0.000
S30.9 Superficial injury of abdomen, lower back and pelvis, part unspecified	0.629	0.371	0.000
D04.3 Skin of other and unspecified parts of face	0.629	0.371	0.000
S22.2 Fracture of sternum	0.628	0.372	0.000
Y45.2 Propionic acid derivatives	0.627	0.373	0.000
T92.3 Sequelae of dislocation, sprain and strain of upper limb	0.627	0.373	0.000
C71.1 Frontal lobe	0.627	0.373	0.000
S32.5 Fracture of pubis	0.626	0.374	0.000
M45-M49 Spondylopathies	0.626	0.374	0.000
I72 Other aneurysm	0.625	0.375	0.000
I77.5 Necrosis of artery	0.625	0.375	0.000
I77.4 Coeliac artery compression syndrome	0.625	0.375	0.000
I77.3 Arterial fibromuscular dysplasia	0.625	0.375	0.000
I77.2 Rupture of artery	0.625	0.375	0.000
L20-L30 Dermatitis and eczema	0.625	0.375	0.000
W18 Other fall on same level	0.625	0.375	0.000
Y54.4 Loop [high-ceiling] diuretics	0.624	0.375	0.000
N10-N16 Renal tubulo-interstitial diseases	0.624	0.376	0.000
S22.1 Multiple fractures of thoracic spine	0.623	0.376	0.000
M87 Osteonecrosis	0.623	0.376	0.000
Q27 Other congenital malformations of peripheral vascular system	0.623	0.377	0.000
Y46.4 Iminostilbenes	0.623	0.377	0.000
C02.8 Overlapping lesion of tongue	0.623	0.377	0.000
C02.4 Lingual tonsil	0.623	0.377	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations