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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs12649659
log Bayes Factor = 7.83863
Chromosome 4   position 91,852,652  (GRCh37) Explore rs12649659 on Ensembl!
Variant rs12649659 is part of Cluster X0127

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
S00-S09 Injuries to the head
1.000 0.000 0.000
Chapter XI Diseases of the digestive system
0.996 0.004 0.000
K70-K77 Diseases of liver
0.996 0.004 0.000
S01 Open wound of head
0.995 0.005 0.000
M05-M14 Inflammatory polyarthropathies
0.995 0.005 0.000
M20-M25 Other joint disorders
0.994 0.006 0.000
M20 Acquired deformities of fingers and toes
0.987 0.013 0.000
Chapter XX External causes of morbidity and mortality
0.987 0.013 0.000
K80-K87 Disorders of gallbladder, biliary tract and pancreas
0.984 0.016 0.000
K70 Alcoholic liver disease
0.982 0.018 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.980 0.020 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.978 0.022 0.000
K76 Other diseases of liver
0.978 0.022 0.000
T81.4 Infection following a procedure, not elsewhere classified
0.976 0.024 0.000
T81 Complications of procedures, not elsewhere classified
0.974 0.026 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.972 0.028 0.000
S01.0 Open wound of scalp
0.965 0.035 0.000
W00-W19 Falls
0.965 0.035 0.000
K83 Other diseases of biliary tract
0.965 0.035 0.000
K35-K38 Diseases of appendix
0.964 0.036 0.000
M25 Other joint disorders, not elsewhere classified
0.963 0.037 0.000
M20.4 Other hammer toe(s) (acquired)
0.962 0.038 0.000
M25.5 Pain in joint
0.955 0.045 0.000
M45-M49 Spondylopathies
0.955 0.045 0.000
M10 Gout
0.948 0.052 0.000
W19 Unspecified fall
0.948 0.052 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.946 0.054 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.945 0.055 0.000
M13 Other arthritis
0.943 0.057 0.000
S01.8 Open wound of other parts of head
0.942 0.058 0.000
M20.1 Hallux valgus (acquired)
0.939 0.061 0.000
K70.9 Alcoholic liver disease, unspecified
0.937 0.063 0.000
D70 Agranulocytosis
0.926 0.074 0.000
S00 Superficial injury of head
0.922 0.078 0.000
M10.9 Gout, unspecified
0.915 0.085 0.000
K83.1 Obstruction of bile duct
0.914 0.086 0.000
S09 Other and unspecified injuries of head
0.913 0.087 0.000
S80-S89 Injuries to the knee and lower leg
0.910 0.090 0.000
V10-V19 Pedal cyclist injured in transport accident
0.910 0.090 0.000
T91 Sequelae of injuries of neck and trunk
0.906 0.094 0.000
K35 Acute appendicitis
0.904 0.096 0.000
S70-S79 Injuries to the hip and thigh
0.897 0.103 0.000
W19.9 Unspecified place
0.897 0.103 0.000
M15-M19 Arthrosis
0.895 0.105 0.000
K83.8 Other specified diseases of biliary tract
0.892 0.108 0.000
T90 Sequelae of injuries of head
0.890 0.110 0.000
M45 Ankylosing spondylitis
0.889 0.111 0.000
M25.55 Pain in joint (Pelvic region and thigh)
0.888 0.112 0.000
K37 Unspecified appendicitis
0.882 0.118 0.000
T66-T78 Other and unspecified effects of external causes
0.882 0.118 0.000
M10.97 Gout, unspecified (Ankle and foot)
0.880 0.120 0.000
T81.2 Accidental puncture and laceration during a procedure, not elsewhere classified
0.879 0.121 0.000
W19.4 Street and highway
0.879 0.121 0.000
M13.9 Arthritis, unspecified
0.876 0.124 0.000
M65-M68 Disorders of synovium and tendon
0.874 0.126 0.000
M34 Systemic sclerosis
0.871 0.129 0.000
K76.9 Liver disease, unspecified
0.869 0.131 0.000
M86-M90 Other osteopathies
0.860 0.140 0.000
M20.0 Deformity of finger(s)
0.858 0.142 0.000
T79-T79 Certain early complications of trauma
0.858 0.142 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.857 0.143 0.000
S60-S69 Injuries to the wrist and hand
0.857 0.143 0.000
M46 Other inflammatory spondylopathies
0.855 0.144 0.000
V18 Pedal cyclist injured in noncollision transport accident
0.855 0.145 0.000
M05 Seropositive rheumatoid arthritis
0.853 0.147 0.000
K76.6 Portal hypertension
0.852 0.148 0.000
S09.9 Unspecified injury of head
0.852 0.148 0.000
M25.50 Pain in joint (Multiple sites)
0.848 0.152 0.000
S90-S99 Injuries to the ankle and foot
0.844 0.156 0.000
M25.53 Pain in joint (Forearm)
0.842 0.158 0.000
Chapter I Certain infectious and parasitic diseases
0.842 0.158 0.000
K86 Other diseases of pancreas
0.841 0.159 0.000
K76.0 Fatty (change of) liver, not elsewhere classified
0.840 0.160 0.000
K76.8 Other specified diseases of liver
0.838 0.162 0.000
M45.X9 Ankylosing spondylitis (Site unspecified)
0.832 0.168 0.000
T91.8 Sequelae of other specified injuries of neck and trunk
0.831 0.169 0.000
K70.0 Alcoholic fatty liver
0.830 0.170 0.000
S05 Injury of eye and orbit
0.828 0.172 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.824 0.176 0.000
T90.2 Sequelae of fracture of skull and facial bones
0.824 0.176 0.000
K82 Other diseases of gallbladder
0.823 0.177 0.000
K35.8 Acute appendicitis, other and unspecified
0.823 0.177 0.000
M25.54 Pain in joint (Hand)
0.821 0.179 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.821 0.179 0.000
S80 Superficial injury of lower leg
0.821 0.179 0.000
M06 Other rheumatoid arthritis
0.820 0.180 0.000
M80-M85 Disorders of bone density and structure
0.819 0.181 0.000
M16 Coxarthrosis [arthrosis of hip]
0.818 0.182 0.000
T92 Sequelae of injuries of upper limb
0.817 0.183 0.000
S01.1 Open wound of eyelid and periocular area
0.815 0.185 0.000
Q60-Q64 Congenital malformations of the urinary system
0.809 0.190 0.000
S10-S19 Injuries to the neck
0.806 0.194 0.000
M19 Other arthrosis
0.805 0.195 0.000
M13.97 Arthritis, unspecified (Ankle and foot)
0.804 0.196 0.000
M25.51 Pain in joint (Shoulder region)
0.804 0.196 0.000
S82 Fracture of lower leg, including ankle
0.801 0.199 0.000
S00.9 Superficial injury of head, part unspecified
0.801 0.199 0.000
D55-D59 Haemolytic anaemias
0.799 0.201 0.000
M13.98 Arthritis, unspecified (Other)
0.798 0.202 0.000
Chapter XXII Codes for special purposes
0.798 0.202 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.797 0.203 0.000
S00.8 Superficial injury of other parts of head
0.794 0.206 0.000
M13.0 Polyarthritis, unspecified
0.794 0.206 0.000
S72 Fracture of femur
0.793 0.207 0.000
K70.3 Alcoholic cirrhosis of liver
0.793 0.207 0.000
S01.7 Multiple open wounds of head
0.792 0.208 0.000
W50-W64 Exposure to animate mechanical forces
0.792 0.208 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.790 0.210 0.000
S20-S29 Injuries to the thorax
0.787 0.212 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.787 0.213 0.000
M46.9 Inflammatory spondylopathy, unspecified
0.785 0.215 0.000
K70.1 Alcoholic hepatitis
0.783 0.217 0.000
V18.0 Driver injured in nontraffic accident
0.782 0.218 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.777 0.222 0.000
S02 Fracture of skull and facial bones
0.776 0.224 0.000
M16.1 Other primary coxarthrosis
0.775 0.225 0.000
W01 Fall on same level from slipping, tripping and stumbling
0.772 0.228 0.000
M13.90 Arthritis, unspecified (Multiple sites)
0.770 0.230 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.770 0.230 0.000
X50-X57 Overexertion, travel and privation
0.770 0.230 0.000
K86.8 Other specified diseases of pancreas
0.765 0.235 0.000
M20.3 Other deformity of hallux (acquired)
0.765 0.235 0.000
K70.4 Alcoholic hepatic failure
0.764 0.236 0.000
S01.5 Open wound of lip and oral cavity
0.762 0.238 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.759 0.241 0.000
K73 Chronic hepatitis, not elsewhere classified
0.758 0.242 0.000
S86 Injury of muscle and tendon at lower leg level
0.758 0.242 0.000
M34.9 Systemic sclerosis, unspecified
0.757 0.243 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.756 0.244 0.000
M60-M63 Disorders of muscles
0.753 0.246 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.752 0.248 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.751 0.249 0.000
M46.99 Inflammatory spondylopathy, unspecified (Site unspecified)
0.750 0.250 0.000
M25.58 Pain in joint (Other)
0.748 0.251 0.000
M24 Other specific joint derangements
0.748 0.252 0.000
S82.1 Fracture of upper end of tibia
0.747 0.252 0.000
T98 Sequelae of other and unspecified effects of external causes
0.742 0.258 0.000
M65 Synovitis and tenosynovitis
0.742 0.258 0.000
K86.1 Other chronic pancreatitis
0.741 0.259 0.000
M84 Disorders of continuity of bone
0.741 0.259 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.739 0.261 0.000
D73 Diseases of spleen
0.739 0.261 0.000
M00-M03 Infectious arthropathies
0.738 0.262 0.000
S01.2 Open wound of nose
0.738 0.262 0.000
T68 Hypothermia
0.737 0.263 0.000
K74 Fibrosis and cirrhosis of liver
0.736 0.264 0.000
S73 Dislocation, sprain and strain of joint and ligaments of hip
0.736 0.264 0.000
V40-V49 Car occupant injured in transport accident
0.735 0.265 0.000
W18 Other fall on same level
0.735 0.265 0.000
V80-V89 Other land transport accidents
0.733 0.267 0.000
K80 Cholelithiasis
0.733 0.267 0.000
S00.3 Superficial injury of nose
0.733 0.267 0.000
A30-A49 Other bacterial diseases
0.730 0.270 0.000
M19.9 Arthrosis, unspecified
0.729 0.271 0.000
S80.9 Superficial injury of lower leg, unspecified
0.727 0.273 0.000
M10.96 Gout, unspecified (Lower leg)
0.725 0.275 0.000
W19.2 School, other institution and public administrative area
0.725 0.275 0.000
V18.2 Unspecified pedal cyclist injured in nontraffic accident
0.724 0.276 0.000
X20-X29 Contact with venomous animals and plants
0.724 0.276 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.723 0.277 0.000
Q63 Other congenital malformations of kidney
0.722 0.278 0.000
S68 Traumatic amputation of wrist and hand
0.722 0.278 0.000
M70-M79 Other soft tissue disorders
0.721 0.279 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.721 0.279 0.000
M25.0 Haemarthrosis
0.720 0.279 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.719 0.281 0.000
K35.9 Acute appendicitis, unspecified
0.718 0.282 0.000
T66 Unspecified effects of radiation
0.718 0.282 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
S08 Traumatic amputation of part of head
0.717 0.283 0.000
S07 Crushing injury of head
0.717 0.283 0.000
S04 Injury of cranial nerves
0.717 0.283 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.717 0.283 0.000
B15-B19 Viral hepatitis
0.716 0.284 0.000
K77 Liver disorders in diseases classified elsewhere
0.714 0.286 0.000
K71 Toxic liver disease
0.714 0.286 0.000
M14 Arthropathies in other diseases classified elsewhere
0.713 0.287 0.000
M12 Other specific arthropathies
0.713 0.287 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.713 0.287 0.000
M08 Juvenile arthritis
0.713 0.287 0.000
T86 Failure and rejection of transplanted organs and tissues
0.713 0.287 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.712 0.287 0.000
M33 Dermatopolymyositis
0.712 0.287 0.000
M32 Systemic lupus erythematosus
0.712 0.287 0.000
M30 Polyarteritis nodosa and related conditions
0.712 0.287 0.000
M25.52 Pain in joint (Upper arm)
0.712 0.288 0.000
M13.94 Arthritis, unspecified (Hand)
0.711 0.289 0.000
S72.0 Fracture of neck of femur
0.709 0.291 0.000
S82.10 Fracture of upper end of tibia (closed)
0.709 0.291 0.000
K35.3 Acute appendicitis with localized peritonitis
0.708 0.292 0.000
K65-K67 Diseases of peritoneum
0.708 0.292 0.000
W06 Fall involving bed
0.708 0.292 0.000
Y35-Y36 Legal intervention and operations of war
0.708 0.292 0.000
Y10-Y34 Event of undetermined intent
0.708 0.292 0.000
Y00-Y09 Assault
0.708 0.292 0.000
X85-X99 Assault
0.708 0.292 0.000
X30-X39 Exposure to forces of nature
0.708 0.292 0.000
X10-X19 Contact with heat and hot substances
0.708 0.292 0.000
X00-X09 Exposure to smoke, fire and flames
0.708 0.292 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.708 0.292 0.000
W75-W84 Other accidental threats to breathing
0.708 0.292 0.000
W65-W74 Accidental drowning and submersion
0.708 0.292 0.000
V98-V99 Other and unspecified transport accidents
0.708 0.292 0.000
V95-V97 Air and space transport accidents
0.708 0.292 0.000
V90-V94 Water transport accidents
0.708 0.292 0.000
V70-V79 Bus occupant injured in transport accident
0.708 0.292 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.708 0.292 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.708 0.292 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.708 0.292 0.000
V01-V09 Pedestrian injured in transport accident
0.708 0.292 0.000
S62 Fracture at wrist and hand level
0.706 0.294 0.000
K87 Disorders of gallbladder, biliary tract and pancreas in diseases classified elsewhere
0.706 0.294 0.000
Y43 Primarily systemic agents
0.705 0.295 0.000
D75 Other diseases of blood and blood-forming organs
0.705 0.295 0.000
K70.2 Alcoholic fibrosis and sclerosis of liver
0.704 0.296 0.000
T87 Complications peculiar to reattachment and amputation
0.702 0.298 0.000
W17 Other fall from one level to another
0.702 0.298 0.000
T95 Sequelae of burns, corrosions and frostbite
0.701 0.299 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.701 0.299 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.701 0.299 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.701 0.299 0.000
K76.7 Hepatorenal syndrome
0.701 0.299 0.000
K76.5 Hepatic veno-occlusive disease
0.701 0.299 0.000
K76.4 Peliosis hepatis
0.701 0.299 0.000
K76.3 Infarction of liver
0.701 0.299 0.000
K76.2 Central haemorrhagic necrosis of liver
0.701 0.299 0.000
K76.1 Chronic passive congestion of liver
0.701 0.299 0.000
M89 Other disorders of bone
0.701 0.299 0.000
W02 Fall involving ice-skates, skis, roller-skates or skateboards
0.701 0.299 0.000
K75 Other inflammatory liver diseases
0.701 0.299 0.000
K82.4 Cholesterolosis of gallbladder
0.701 0.299 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.700 0.300 0.000
M25.3 Other instability of joint
0.699 0.301 0.000
T91.1 Sequelae of fracture of spine
0.699 0.301 0.000
T81.6 Acute reaction to foreign substance accidentally left during a procedure
0.698 0.302 0.000
T81.1 Shock during or resulting from a procedure, not elsewhere classified
0.698 0.302 0.000
S71 Open wound of hip and thigh
0.697 0.303 0.000
D68 Other coagulation defects
0.695 0.305 0.000
K35.0 Acute appendicitis with generalised peritonitis
0.695 0.305 0.000
S00.1 Contusion of eyelid and periocular area
0.695 0.305 0.000
Q24 Other congenital malformations of heart
0.694 0.306 0.000
W16 Diving or jumping into water causing injury other than drowning or submersion
0.692 0.308 0.000
W15 Fall from cliff
0.692 0.308 0.000
W14 Fall from tree
0.692 0.308 0.000
W12 Fall on and from scaffolding
0.692 0.308 0.000
W11 Fall on and from ladder
0.692 0.308 0.000
W09 Fall involving playground equipment
0.692 0.308 0.000
W08 Fall involving other furniture
0.692 0.308 0.000
W05 Fall involving wheelchair
0.692 0.308 0.000
W04 Fall while being carried or supported by other persons
0.692 0.308 0.000
W03 Other fall on same level due to collision with, or pushing by, another person
0.692 0.308 0.000
W00 Fall on same level involving ice and snow
0.692 0.308 0.000
K83.9 Disease of biliary tract, unspecified
0.692 0.308 0.000
K83.5 Biliary cyst
0.692 0.308 0.000
K83.4 Spasm of sphincter of Oddi
0.692 0.308 0.000
K83.3 Fistula of bile duct
0.692 0.308 0.000
K83.2 Perforation of bile duct
0.692 0.308 0.000
M87 Osteonecrosis
0.691 0.309 0.000
M25.9 Joint disorder, unspecified
0.691 0.309 0.000
M25.2 Flail joint
0.691 0.309 0.000
M25.1 Fistula of joint
0.691 0.309 0.000
S00.7 Multiple superficial injuries of head
0.691 0.309 0.000
M95.0 Acquired deformity of nose
0.689 0.311 0.000
T91.3 Sequelae of injury of spinal cord
0.687 0.313 0.000
M25.57 Pain in joint (Ankle and foot)
0.686 0.314 0.000
M47 Spondylosis
0.686 0.314 0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.685 0.315 0.000
Chapter V Mental and behavioural disorders
0.685 0.315 0.000
M15 Polyarthrosis
0.685 0.315 0.000
K83.0 Cholangitis
0.685 0.315 0.000
M49 Spondylopathies in diseases classified elsewhere
0.684 0.316 0.000
S01.3 Open wound of ear
0.683 0.317 0.000
M06.4 Inflammatory polyarthropathy
0.683 0.317 0.000
M11 Other crystal arthropathies
0.683 0.317 0.000
X60-X84 Intentional self-harm
0.682 0.318 0.000
S80.0 Contusion of knee
0.682 0.318 0.000
Q50-Q56 Congenital malformations of genital organs
0.682 0.318 0.000
S82.4 Fracture of fibula alone
0.681 0.319 0.000
W07 Fall involving chair
0.681 0.319 0.000
S05.8 Other injuries of eye and orbit
0.681 0.319 0.000
M67 Other disorders of synovium and tendon
0.680 0.320 0.000
M10.4 Other secondary gout
0.680 0.320 0.000
M10.3 Gout due to impairment of renal function
0.680 0.320 0.000
M10.2 Drug-induced gout
0.680 0.320 0.000
M10.1 Lead-induced gout
0.680 0.320 0.000
M10.0 Idiopathic gout
0.680 0.320 0.000
T92.2 Sequelae of fracture at wrist and hand level
0.680 0.320 0.000
Y43.3 Other antineoplastic drugs
0.680 0.320 0.000
M34.1 CR(E)ST syndrome
0.680 0.320 0.000
W19.8 Other specified place
0.679 0.320 0.000
W19.5 Trade and service area
0.679 0.320 0.000
W19.0 Home
0.679 0.320 0.000
W19.7 Farm
0.679 0.320 0.000
W19.6 Industrial and construction area
0.679 0.320 0.000
W19.1 Residential institution
0.679 0.320 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.678 0.322 0.000
D74 Methaemoglobinaemia
0.678 0.322 0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.678 0.322 0.000
D71 Functional disorders of polymorphonuclear neutrophils
0.678 0.322 0.000
M10.99 Gout, unspecified (Site unspecified)
0.678 0.322 0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver
0.678 0.322 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.678 0.322 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.678 0.322 0.000
S96 Injury of muscle and tendon at ankle and foot level
0.678 0.322 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.677 0.323 0.000
Q35-Q37 Cleft lip and cleft palate
0.677 0.323 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.677 0.323 0.000
K72 Hepatic failure, not elsewhere classified
0.677 0.323 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.676 0.324 0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level
0.676 0.324 0.000
M13.8 Other specified arthritis
0.676 0.324 0.000
M13.1 Monoarthritis, not elsewhere classified
0.676 0.324 0.000
S80.1 Contusion of other and unspecified parts of lower leg
0.676 0.324 0.000
W20-W49 Exposure to inanimate mechanical forces
0.674 0.326 0.000
M06.0 Seronegative rheumatoid arthritis
0.674 0.326 0.000
K85 Acute pancreatitis
0.673 0.327 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.673 0.327 0.000
M84.1 Nonunion of fracture [pseudarthrosis]
0.672 0.328 0.000
M16.0 Primary coxarthrosis, bilateral
0.669 0.331 0.000
M31 Other necrotising vasculopathies
0.669 0.331 0.000
B25-B34 Other viral diseases
0.668 0.332 0.000
K80.5 Calculus of bile duct without cholangitis or cholecystitis
0.668 0.332 0.000
S90 Superficial injury of ankle and foot
0.663 0.337 0.000
S72.2 Subtrochanteric fracture
0.663 0.337 0.000
K36 Other appendicitis
0.662 0.338 0.000
T80.2 Infections following infusion, transfusion and therapeutic injection
0.661 0.339 0.000
Q38 Other congenital malformations of tongue, mouth and pharynx
0.661 0.339 0.000
S00.5 Superficial injury of lip and oral cavity
0.661 0.339 0.000
S00.4 Superficial injury of ear
0.661 0.339 0.000
S00.2 Other superficial injuries of eyelid and periocular area
0.660 0.340 0.000
T78 Adverse effects, not elsewhere classified
0.659 0.341 0.000
S60 Superficial injury of wrist and hand
0.659 0.341 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.658 0.341 0.000
M25.59 Pain in joint (Site unspecified)
0.658 0.342 0.000
M66 Spontaneous rupture of synovium and tendon
0.658 0.342 0.000
M10.98 Gout, unspecified (Other)
0.656 0.344 0.000
M10.95 Gout, unspecified (Pelvic region and thigh)
0.656 0.344 0.000
M10.94 Gout, unspecified (Hand)
0.656 0.344 0.000
M10.93 Gout, unspecified (Forearm)
0.656 0.344 0.000
M10.92 Gout, unspecified (Upper arm)
0.656 0.344 0.000
M10.91 Gout, unspecified (Shoulder region)
0.656 0.344 0.000
M10.90 Gout, unspecified (Multiple sites)
0.656 0.344 0.000
T90.5 Sequelae of intracranial injury
0.655 0.344 0.000
Q00-Q07 Congenital malformations of the nervous system
0.655 0.345 0.000
S09.8 Other specified injuries of head
0.655 0.345 0.000
S09.7 Multiple injuries of head
0.655 0.345 0.000
S09.2 Traumatic rupture of ear drum
0.655 0.345 0.000
S09.1 Injury of muscle and tendon of head
0.655 0.345 0.000
S09.0 Injury of blood vessels of head, not elsewhere classified
0.655 0.345 0.000
Q63.0 Accessory kidney
0.653 0.347 0.000
T81.7 Vascular complications following a procedure, not elsewhere classified
0.653 0.347 0.000
A00-A09 Intestinal infectious diseases
0.653 0.347 0.000
S88 Traumatic amputation of lower leg
0.653 0.347 0.000
S87 Crushing injury of lower leg
0.653 0.347 0.000
S85 Injury of blood vessels at lower leg level
0.653 0.347 0.000
S84 Injury of nerves at lower leg level
0.653 0.347 0.000
V19 Pedal cyclist injured in other and unspecified transport accidents
0.652 0.347 0.000
V17 Pedal cyclist injured in collision with fixed or stationary object
0.652 0.347 0.000
V16 Pedal cyclist injured in collision with other nonmotor vehicle
0.652 0.347 0.000
V15 Pedal cyclist injured in collision with railway train or railway vehicle
0.652 0.347 0.000
V14 Pedal cyclist injured in collision with heavy transport vehicle or bus
0.652 0.347 0.000
V13 Pedal cyclist injured in collision with car, pick-up truck or van
0.652 0.347 0.000
V12 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle
0.652 0.347 0.000
V11 Pedal cyclist injured in collision with other pedal cycle
0.652 0.347 0.000
V10 Pedal cyclist injured in collision with pedestrian or animal
0.652 0.347 0.000
M13.93 Arthritis, unspecified (Forearm)
0.652 0.348 0.000
W55 Bitten or struck by other mammals
0.652 0.348 0.000
M16.5 Other posttraumatic coxarthrosis
0.651 0.349 0.000
T91.9 Sequelae of unspecified injury of neck and trunk
0.650 0.350 0.000
T91.5 Sequelae of injury of intra-abdominal and pelvic organs
0.650 0.350 0.000
T91.4 Sequelae of injury of intrathoracic organs
0.650 0.350 0.000
T91.2 Sequelae of other fracture of thorax and pelvis
0.650 0.350 0.000
T91.0 Sequelae of superficial injury and open wound of neck and trunk
0.650 0.350 0.000
S72.00 Fracture of neck of femur (closed)
0.649 0.351 0.000
K35.2 Acute appendicitis with generalized peritonitis
0.648 0.352 0.000
B65-B83 Helminthiases
0.648 0.352 0.000
S70 Superficial injury of hip and thigh
0.648 0.352 0.000
M86 Osteomyelitis
0.648 0.352 0.000
S19 Other and unspecified injuries of neck
0.647 0.353 0.000
Q80-Q89 Other congenital malformations
0.645 0.355 0.000
M07 Psoriatic and enteropathic arthropathies
0.644 0.356 0.000
K38 Other diseases of appendix
0.644 0.356 0.000
V20-V29 Motorcycle rider injured in transport accident
0.644 0.356 0.000
M13.09 Polyarthritis, unspecified (Site unspecified)
0.644 0.356 0.000
S78 Traumatic amputation of hip and thigh
0.643 0.357 0.000
S77 Crushing injury of hip and thigh
0.643 0.357 0.000
S76 Injury of muscle and tendon at hip and thigh level
0.643 0.357 0.000
S75 Injury of blood vessels at hip and thigh level
0.643 0.357 0.000
S74 Injury of nerves at hip and thigh level
0.643 0.357 0.000
D80-D89 Certain disorders involving the immune mechanism
0.641 0.359 0.000
W19.3 Sports and athletics area
0.641 0.359 0.000
S01.9 Open wound of head, part unspecified
0.640 0.360 0.000
T79.6 Traumatic ischaemia of muscle
0.639 0.361 0.000
T90.4 Sequelae of injury of eye and orbit
0.639 0.361 0.000
M21 Other acquired deformities of limbs
0.639 0.361 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.638 0.362 0.000
T90.8 Sequelae of other specified injuries of head
0.638 0.362 0.000
T90.3 Sequelae of injury of cranial nerves
0.638 0.362 0.000
T90.1 Sequelae of open wound of head
0.638 0.362 0.000
T90.0 Sequelae of superficial injury of head
0.638 0.362 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.638 0.362 0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.638 0.362 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.638 0.362 0.000
M45.X6 Ankylosing spondylitis (Lumbar region)
0.638 0.362 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.638 0.362 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.638 0.362 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.638 0.362 0.000
M45.X2 Ankylosing spondylitis (Cervical region)
0.638 0.362 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.638 0.362 0.000
S82.2 Fracture of shaft of tibia
0.638 0.362 0.000
M25.7 Osteophyte
0.634 0.366 0.000
M13.00 Polyarthritis, unspecified (Multiple sites)
0.634 0.366 0.000
W01.1 Residential institution
0.634 0.366 0.000
S01.4 Open wound of cheek and temporomandibular area
0.633 0.367 0.000
M19.93 Arthrosis, unspecified (Forearm)
0.633 0.367 0.000
D69 Purpura and other haemorrhagic conditions
0.633 0.367 0.000
S05.1 Contusion of eyeball and orbital tissues
0.633 0.367 0.000
K82.1 Hydrops of gallbladder
0.633 0.367 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.633 0.367 0.000
M19.98 Arthrosis, unspecified (Other)
0.633 0.367 0.000
T75 Effects of other external causes
0.632 0.368 0.000
T74 Maltreatment syndromes
0.632 0.368 0.000
T73 Effects of other deprivation
0.632 0.368 0.000
T70 Effects of air pressure and water pressure
0.632 0.368 0.000
T69 Other effects of reduced temperature
0.632 0.368 0.000
T67 Effects of heat and light
0.632 0.368 0.000
T71 Asphyxiation
0.632 0.368 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.632 0.368 0.000
D58 Other hereditary haemolytic anaemias
0.632 0.368 0.000
D59 Acquired haemolytic anaemia
0.630 0.370 0.000
M19.2 Other secondary arthrosis
0.630 0.370 0.000
D68.2 Hereditary deficiency of other clotting factors
0.629 0.371 0.000
M13.92 Arthritis, unspecified (Upper arm)
0.628 0.372 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.628 0.372 0.000
T90.9 Sequelae of unspecified injury of head
0.628 0.372 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.626 0.373 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.626 0.373 0.000
D60-D64 Aplastic and other anaemias
0.626 0.374 0.000
M34.8 Other forms of systemic sclerosis
0.624 0.375 0.000
M34.2 Systemic sclerosis induced by drugs and chemicals
0.624 0.375 0.000
M34.0 Progressive systemic sclerosis
0.624 0.375 0.000
T83.3 Mechanical complication of intra-uterine contraceptive device
0.624 0.376 0.000
S67 Crushing injury of wrist and hand
0.624 0.376 0.000
W13 Fall from, out of or through building or structure
0.623 0.376 0.000
S66.1 Injury of flexor muscle and tendon of other finger at wrist and hand level
0.623 0.377 0.000
S22.0 Fracture of thoracic vertebra
0.623 0.377 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.622 0.378 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.622 0.378 0.000
S73.0 Dislocation of hip
0.620 0.379 0.000
M67.2 Synovial hypertrophy, not elsewhere classified
0.620 0.380 0.000
Y88 Sequelae of surgical and medical care as external cause
0.620 0.380 0.000
M91-M94 Chondropathies
0.618 0.382 0.000
M88 Paget's disease of bone [osteitis deformans]
0.617 0.383 0.000
M99 Biomechanical lesions, not elsewhere classified
0.614 0.385 0.000
K82.8 Other specified diseases of gallbladder
0.615 0.385 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.614 0.386 0.000
S65 Injury of blood vessels at wrist and hand level
0.614 0.386 0.000
X51 Travel and motion
0.614 0.386 0.000
M46.8 Other specified inflammatory spondylopathies
0.613 0.387 0.000
M46.5 Other infective spondylopathies
0.613 0.387 0.000
M46.4 Discitis, unspecified
0.613 0.387 0.000
M46.3 Infection of intervertebral disk (pyogenic)
0.613 0.387 0.000
M46.2 Osteomyelitis of vertebra
0.613 0.387 0.000
M46.1 Sacro-iliitis, not elsewhere classified
0.613 0.387 0.000
M46.0 Spinal enthesopathy
0.613 0.387 0.000
Y89 Sequelae of other external causes
0.613 0.387 0.000
T83.8 Other complications of genito-urinary prosthetic devices, implants and grafts
0.613 0.387 0.000
V18.9 Unspecified pedal cyclist injured in traffic accident
0.613 0.387 0.000
V18.4 Driver injured in traffic accident
0.613 0.387 0.000
V18.5 Passenger injured in traffic accident
0.613 0.387 0.000
V18.3 Person injured while boarding or alighting
0.613 0.387 0.000
V18.1 Passenger injured in nontraffic accident
0.613 0.387 0.000
M19.97 Arthrosis, unspecified (Ankle and foot)
0.613 0.387 0.000
Q43 Other congenital malformations of intestine
0.613 0.387 0.000
M19.90 Arthrosis, unspecified (Multiple sites)
0.613 0.387 0.000
M65.3 Trigger finger
0.613 0.387 0.000
B18 Chronic viral hepatitis
0.612 0.388 0.000
M80 Osteoporosis with pathological fracture
0.612 0.388 0.000
M05.8 Other seropositive rheumatoid arthritis
0.611 0.388 0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.611 0.388 0.000
M05.2 Rheumatoid vasculitis
0.611 0.388 0.000
M05.1 Rheumatoid lung disease
0.611 0.388 0.000
M05.0 Felty's syndrome
0.611 0.388 0.000
A41 Other septicaemia
0.611 0.389 0.000
S40-S49 Injuries to the shoulder and upper arm
0.611 0.389 0.000
S13 Dislocation, sprain and strain of joints and ligaments at neck level
0.611 0.389 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.610 0.390 0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.610 0.390 0.000
S86.8 Injury of other muscles and tendons at lower leg level
0.609 0.391 0.000
K35.1 Acute appendicitis with peritoneal abscess
0.609 0.391 0.000
M71 Other bursopathies
0.606 0.394 0.000
T92.9 Sequelae of unspecified injury of upper limb
0.606 0.394 0.000
A40 Streptococcal septicaemia
0.606 0.394 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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