TreeWAS – Variant ID: rs12721109

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E78.0 Pure hypercholesterolaemia	0.000	0.000	1.000
I25.1 Atherosclerotic heart disease	0.000	0.000	1.000
I25 Chronic ischaemic heart disease	0.000	0.000	1.000
I20-I25 Ischaemic heart diseases	0.000	0.000	1.000
I20 Angina pectoris	0.000	0.000	1.000
I20.9 Angina pectoris, unspecified	0.000	0.000	1.000
I21 Acute myocardial infarction	0.000	0.005	0.995
I25.8 Other forms of chronic ischaemic heart disease	0.000	0.007	0.993
I25.2 Old myocardial infarction	0.000	0.010	0.990
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.000	0.017	0.982
E78.5 Hyperlipidaemia, unspecified	0.000	0.021	0.979
I21.9 Acute myocardial infarction, unspecified	0.000	0.040	0.960
I25.9 Chronic ischaemic heart disease, unspecified	0.000	0.057	0.943
I21.1 Acute transmural myocardial infarction of inferior wall	0.000	0.107	0.893
I20.8 Other forms of angina pectoris	0.000	0.123	0.877
I20.0 Unstable angina	0.000	0.124	0.876
I21.4 Acute subendocardial myocardial infarction	0.000	0.135	0.865
I21.2 Acute transmural myocardial infarction of other sites	0.000	0.191	0.809
I25.5 Ischaemic cardiomyopathy	0.000	0.206	0.794
E78.9 Disorder of lipoprotein metabolism, unspecified	0.000	0.238	0.762
I21.0 Acute transmural myocardial infarction of anterior wall	0.000	0.266	0.734
I25.6 Silent myocardial ischaemia	0.000	0.283	0.717
I25.4 Coronary artery aneurysm	0.000	0.283	0.717
I25.3 Aneurysm of heart	0.000	0.283	0.717
I25.0 Atherosclerotic cardiovascular disease, so described	0.000	0.283	0.717
I23 Certain current complications following acute myocardial infarction	0.000	0.283	0.717
I21.X Presumed acute myicardial infaction (unconfirmed)	0.000	0.287	0.713
I21.3 Acute transmural myocardial infarction of unspecified site	0.000	0.287	0.713
I22 Subsequent myocardial infarction	0.000	0.287	0.713
E78.6 Lipoprotein deficiency	0.000	0.295	0.704
E78.4 Other hyperlipidaemia	0.000	0.295	0.704
E78.3 Hyperchylomicronaemia	0.000	0.295	0.704
E78.1 Pure hyperglyceridaemia	0.000	0.295	0.704
E78.2 Mixed hyperlipidaemia	0.000	0.310	0.690
I20.1 Angina pectoris with documented spasm	0.000	0.311	0.689
I24 Other acute ischaemic heart diseases	0.000	0.341	0.659
E78.8 Other disorders of lipoprotein metabolism	0.000	0.379	0.621
I22.9 Subsequent myocardial infarction of unspecified site	0.000	0.433	0.567
I23.8 Other current complications following acute myocardial infarction	0.000	0.486	0.514
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction	0.000	0.486	0.514
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction	0.000	0.486	0.514
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction	0.000	0.486	0.514
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction	0.000	0.486	0.514
I23.2 Ventricular septal defect as current complication following acute myocardial infarction	0.000	0.486	0.514
I23.1 Atrial septal defect as current complication following acute myocardial infarction	0.000	0.486	0.514
I23.0 Haemopericardium as current complication following acute myocardial infarction	0.000	0.486	0.514
I22.8 Subsequent myocardial infarction of other sites	0.000	0.489	0.511
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.000	0.496	0.504
I22.0 Subsequent myocardial infarction of anterior wall	0.000	0.522	0.478
I24.1 Dressler's syndrome	0.000	0.527	0.472
I22.1 Subsequent myocardial infarction of inferior wall	0.000	0.531	0.469
I24.8 Other forms of acute ischaemic heart disease	0.000	0.556	0.444
I24.9 Acute ischaemic heart disease, unspecified	0.000	0.596	0.404
O60-O75 Complications of labour and delivery	0.253	0.747	0.000
Chapter XV Pregnancy, childbirth and the puerperium	0.246	0.754	0.000
O75 Other complications of labour and delivery, not elsewhere classified	0.245	0.755	0.000
O68 Labour and delivery complicated by foetal stress [distress]	0.242	0.758	0.000
O75.6 Delayed delivery after spontaneous or unspecified rupture of membranes	0.236	0.764	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.235	0.765	0.000
M20-M25 Other joint disorders	0.235	0.765	0.000
O68.2 Labour and delivery complicated by foetal heart rate anomaly with meconium in amniotic fluid	0.230	0.770	0.000
M24 Other specific joint derangements	0.229	0.771	0.000
O68.1 Labour and delivery complicated by meconium in amniotic fluid	0.224	0.776	0.000
M24.0 Loose body in joint	0.223	0.777	0.000
# Top node	0.222	0.778	0.000
O72 Postpartum haemorrhage	0.220	0.780	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.220	0.780	0.000
S80-S89 Injuries to the knee and lower leg	0.220	0.780	0.000
M80-M85 Disorders of bone density and structure	0.219	0.781	0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.218	0.782	0.000
O94-O99 Other obstetric conditions, not elsewhere classified	0.211	0.789	0.000
F40-F48 Neurotic, stress-related and somatoform disorders	0.211	0.789	0.000
Chapter V Mental and behavioural disorders	0.211	0.789	0.000
F41 Other anxiety disorders	0.209	0.791	0.000
F41.2 Mixed anxiety and depressive disorder	0.209	0.791	0.000
M34 Systemic sclerosis	0.208	0.792	0.000
M24.07 Loose body in joint (Ankle and foot)	0.208	0.792	0.000
M50-M54 Other dorsopathies	0.207	0.793	0.000
M24.02 Loose body in joint (Upper arm)	0.204	0.796	0.000
M15-M19 Arthrosis	0.202	0.798	0.000
M25 Other joint disorders, not elsewhere classified	0.202	0.798	0.000
O72.1 Other immediate postpartum haemorrhage	0.201	0.798	0.000
M50 Cervical disk disorders	0.200	0.800	0.000
O85-O92 Complications predominantly related to the puerperium	0.200	0.800	0.000
O68.9 Labour and delivery complicated by foetal stress, unspecified	0.199	0.801	0.000
O75.8 Other specified complications of labour and delivery	0.197	0.802	0.000
M81 Osteoporosis without pathological fracture	0.197	0.803	0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee	0.195	0.805	0.000
Chapter VI Diseases of the nervous system	0.192	0.808	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.192	0.808	0.000
S81 Open wound of lower leg	0.190	0.810	0.000
O64 Obstructed labour due to malposition and malpresentation of foetus	0.189	0.811	0.000
O62 Abnormalities of forces of labour	0.188	0.811	0.000
M19 Other arthrosis	0.188	0.812	0.000
M24.8 Other specific joint derangements, not elsewhere classified	0.187	0.813	0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.187	0.813	0.000
S80 Superficial injury of lower leg	0.187	0.813	0.000
O34 Maternal care for known or suspected abnormality of pelvic organs	0.186	0.813	0.000
S70-S79 Injuries to the hip and thigh	0.186	0.814	0.000
O36 Maternal care for other known or suspected foetal problems	0.186	0.814	0.000
O66 Other obstructed labour	0.186	0.814	0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.184	0.815	0.000
T79-T79 Certain early complications of trauma	0.184	0.816	0.000
S82 Fracture of lower leg, including ankle	0.184	0.816	0.000
O00-O08 Pregnancy with abortive outcome	0.183	0.817	0.000
M70-M79 Other soft tissue disorders	0.183	0.817	0.000
S89 Other and unspecified injuries of lower leg	0.182	0.818	0.000
M18 Arthrosis of first carpometacarpal joint	0.182	0.818	0.000
G20-G26 Extrapyramidal and movement disorders	0.182	0.818	0.000
O74 Complications of anaesthesia during labour and delivery	0.181	0.819	0.000
O71 Other obstetric trauma	0.181	0.819	0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified	0.181	0.819	0.000
O65 Obstructed labour due to maternal pelvic abnormality	0.181	0.819	0.000
O61 Failed induction of labour	0.181	0.819	0.000
O60 Preterm delivery	0.181	0.819	0.000
M86-M90 Other osteopathies	0.181	0.819	0.000
M21 Other acquired deformities of limbs	0.181	0.819	0.000
M22 Disorders of patella	0.181	0.819	0.000
O70 Perineal laceration during delivery	0.181	0.819	0.000
O42 Premature rupture of membranes	0.180	0.820	0.000
M25.4 Effusion of joint	0.180	0.820	0.000
O40 Polyhydramnios	0.180	0.820	0.000
O75.2 Pyrexia during labour, not elsewhere classified	0.180	0.820	0.000
S90-S99 Injuries to the ankle and foot	0.180	0.820	0.000
M34.9 Systemic sclerosis, unspecified	0.179	0.821	0.000
M81.9 Osteoporosis, unspecified	0.178	0.822	0.000
M91-M94 Chondropathies	0.178	0.822	0.000
M50.3 Other cervical disk degeneration	0.177	0.822	0.000
M85 Other disorders of bone density and structure	0.177	0.822	0.000
F45 Somatoform disorders	0.177	0.823	0.000
M23 Internal derangement of knee	0.176	0.824	0.000
M50.1 Cervical disk disorder with radiculopathy	0.176	0.824	0.000
O73 Retained placenta and membranes, without haemorrhage	0.176	0.824	0.000
Chapter I Certain infectious and parasitic diseases	0.176	0.824	0.000
O75.9 Complication of labour and delivery, unspecified	0.176	0.824	0.000
O75.7 Vaginal delivery following previous Caesarean section	0.176	0.824	0.000
O75.5 Delayed delivery after artificial rupture of membranes	0.176	0.824	0.000
O75.4 Other complications of obstetric surgery and procedures	0.176	0.824	0.000
O75.3 Other infection during labour	0.176	0.824	0.000
O75.1 Shock during or following labour and delivery	0.176	0.824	0.000
O75.0 Maternal distress during labour and delivery	0.176	0.824	0.000
S40-S49 Injuries to the shoulder and upper arm	0.174	0.826	0.000
O68.3 Labour and delivery complicated by biochemical evidence of foetal stress	0.174	0.826	0.000
M81.99 Osteoporosis, unspecified (Site unspecified)	0.173	0.827	0.000
T15-T19 Effects of foreign body entering through natural orifice	0.173	0.827	0.000
M84 Disorders of continuity of bone	0.172	0.828	0.000
T20-T25 Burns and corrosions of external body surface, specified by site	0.171	0.828	0.000
S10-S19 Injuries to the neck	0.171	0.829	0.000
F41.9 Anxiety disorder, unspecified	0.171	0.829	0.000
M34.8 Other forms of systemic sclerosis	0.170	0.830	0.000
M40-M43 Deforming dorsopathies	0.170	0.830	0.000
M18.1 Other primary arthrosis of first carpometacarpal joint	0.169	0.831	0.000
M60-M63 Disorders of muscles	0.169	0.831	0.000
F43 Reaction to severe stress, and adjustment disorders	0.169	0.831	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.169	0.831	0.000
M33 Dermatopolymyositis	0.169	0.831	0.000
M32 Systemic lupus erythematosus	0.169	0.831	0.000
M30 Polyarteritis nodosa and related conditions	0.169	0.831	0.000
O80-O84 Delivery	0.168	0.832	0.000
F60-F69 Disorders of adult personality and behaviour	0.168	0.832	0.000
M00-M03 Infectious arthropathies	0.168	0.832	0.000
G90-G99 Other disorders of the nervous system	0.168	0.832	0.000
Q20-Q28 Congenital malformations of the circulatory system	0.167	0.833	0.000
S81.8 Open wound of other parts of lower leg	0.166	0.834	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.166	0.834	0.000
M24.4 Recurrent dislocation and subluxation of joint	0.165	0.835	0.000
M25.46 Effusion of joint (Lower leg)	0.165	0.835	0.000
G25 Other extrapyramidal and movement disorders	0.164	0.835	0.000
M24.9 Joint derangement, unspecified	0.164	0.836	0.000
M24.7 Protrusio acetabuli	0.164	0.836	0.000
M24.6 Ankylosis of joint	0.164	0.836	0.000
M24.5 Contracture of joint	0.164	0.836	0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.164	0.836	0.000
M24.2 Disorder of ligament	0.164	0.836	0.000
O34.2 Maternal care due to uterine scar from previous surgery	0.164	0.836	0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.164	0.836	0.000
M82 Osteoporosis in diseases classified elsewhere	0.163	0.837	0.000
O99.8 Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium	0.162	0.837	0.000
S83.2 Tear of meniscus, current	0.162	0.838	0.000
G20 Parkinson's disease	0.162	0.838	0.000
M25.8 Other specified joint disorders	0.162	0.838	0.000
O35 Maternal care for known or suspected foetal abnormality and damage	0.161	0.839	0.000
S20-S29 Injuries to the thorax	0.161	0.839	0.000
O70.2 Third degree perineal laceration during delivery	0.161	0.839	0.000
S83.4 Sprain and strain involving (fibular)(tibial) collateral ligamnent of knee	0.161	0.839	0.000
Chapter II Neoplasms	0.161	0.839	0.000
M77 Other enthesopathies	0.160	0.840	0.000
M24.09 Loose body in joint (Site unspecified)	0.160	0.840	0.000
M24.08 Loose body in joint (Other)	0.160	0.840	0.000
M24.06 Loose body in joint-Lower leg	0.160	0.840	0.000
M24.05 Loose body in joint (Pelvic region and thigh)	0.160	0.840	0.000
M24.04 Loose body in joint (Hand)	0.160	0.840	0.000
M24.03 Loose body in joint (Forearm)	0.160	0.840	0.000
M24.01 Loose body in joint (Shoulder region)	0.160	0.840	0.000
M24.00 Loose body in joint (Multiple sites)	0.160	0.840	0.000
O69 Labour and delivery complicated by umbilical cord complications	0.160	0.840	0.000
F41.1 Generalised anxiety disorder	0.160	0.840	0.000
M50.2 Other cervical disk displacement	0.160	0.840	0.000
Chapter VII Diseases of the eye and adnexa	0.160	0.840	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.159	0.840	0.000
F42 Obsessive-compulsive disorder	0.159	0.841	0.000
T51 Toxic effect of alcohol	0.159	0.841	0.000
T79 Certain early complications of trauma, not elsewhere classified	0.159	0.841	0.000
M19.9 Arthrosis, unspecified	0.159	0.841	0.000
O02 Other abnormal products of conception	0.158	0.842	0.000
O72.3 Postpartum coagulation defects	0.158	0.842	0.000
O72.2 Delayed and secondary postpartum haemorrhage	0.158	0.842	0.000
T33-T35 Frostbite	0.158	0.842	0.000
T26-T28 Burns and corrosions confined to eye and internal organs	0.158	0.842	0.000
T00-T07 Injuries involving multiple body regions	0.158	0.842	0.000
M19.0 Primary arthrosis of other joints	0.158	0.842	0.000
S88 Traumatic amputation of lower leg	0.158	0.842	0.000
S87 Crushing injury of lower leg	0.158	0.842	0.000
S86 Injury of muscle and tendon at lower leg level	0.158	0.842	0.000
S85 Injury of blood vessels at lower leg level	0.158	0.842	0.000
S84 Injury of nerves at lower leg level	0.158	0.842	0.000
F80-F89 Disorders of psychological development	0.158	0.842	0.000
O87 Venous complications in the puerperium	0.158	0.842	0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.158	0.842	0.000
M31 Other necrotising vasculopathies	0.158	0.842	0.000
O32 Maternal care for known or suspected malpresentation of foetus	0.158	0.842	0.000
O20-O29 Other maternal disorders predominantly related to pregnancy	0.158	0.842	0.000
M23.8 Other internal derangements of knee	0.158	0.842	0.000
M83 Adult osteomalacia	0.157	0.843	0.000
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)	0.157	0.843	0.000
O30 Multiple gestation	0.157	0.843	0.000
O36.6 Maternal care for excessive foetal growth	0.157	0.843	0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.157	0.843	0.000
O45 Premature separation of placenta [abruptio placentae]	0.157	0.843	0.000
O44 Placenta praevia	0.157	0.843	0.000
O43 Placental disorders	0.157	0.843	0.000
O41 Other disorders of amniotic fluid and membranes	0.157	0.843	0.000
O33 Maternal care for known or suspected disproportion	0.157	0.843	0.000
O31 Complications specific to multiple gestation	0.157	0.843	0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.156	0.844	0.000
M25.3 Other instability of joint	0.156	0.844	0.000
S89.9 Unspecified injury of lower leg	0.155	0.845	0.000
M50.0 Cervical disk disorder with myelopathy	0.155	0.845	0.000
O36.8 Maternal care for other specified foetal problems	0.155	0.845	0.000
O90 Complications of the puerperium, not elsewhere classified	0.155	0.845	0.000
S71 Open wound of hip and thigh	0.155	0.845	0.000
O63 Long labour	0.153	0.846	0.000
M79 Other soft tissue disorders, not elsewhere classified	0.153	0.847	0.000
F00-F09 Organic, including symptomatic, mental disorders	0.153	0.847	0.000
S80.9 Superficial injury of lower leg, unspecified	0.153	0.847	0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.153	0.847	0.000
F45.8 Other somatoform disorders	0.152	0.848	0.000
M19.1 Posttraumatic arthrosis of other joints	0.152	0.848	0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites	0.152	0.848	0.000
O98 Maternal infectious and parasitic diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.152	0.848	0.000
O97 Death from sequelae of direct obstetric causes	0.152	0.848	0.000
O96 Death from any obstetric cause occurring more than 42 days but less than one year after delivery	0.152	0.848	0.000
O95 Obstetric death of unspecified cause	0.152	0.848	0.000
O94 Sequelae of complication of pregnancy, childbirth and the puerperium	0.152	0.848	0.000
F48 Other neurotic disorders	0.152	0.848	0.000
F44 Dissociative [conversion] disorders	0.152	0.848	0.000
Chapter XX External causes of morbidity and mortality	0.152	0.848	0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.151	0.849	0.000
F70-F79 Mental retardation	0.151	0.849	0.000
M25.0 Haemarthrosis	0.151	0.849	0.000
Chapter XXII Codes for special purposes	0.151	0.849	0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.151	0.849	0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.151	0.849	0.000
B95-B98 Bacterial, viral and other infectious agents	0.150	0.850	0.000
F41.8 Other specified anxiety disorders	0.150	0.850	0.000
F41.3 Other mixed anxiety disorders	0.150	0.850	0.000
O42.0 Premature rupture of membranes, onset of labour within 24 hours	0.150	0.850	0.000
M34.2 Systemic sclerosis induced by drugs and chemicals	0.150	0.850	0.000
M34.1 CR(E)ST syndrome	0.150	0.850	0.000
M34.0 Progressive systemic sclerosis	0.150	0.850	0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction	0.150	0.850	0.000
G35-G37 Demyelinating diseases of the central nervous system	0.149	0.851	0.000
M53 Other dorsopathies, not elsewhere classified	0.149	0.851	0.000
O36.9 Maternal care for foetal problem, unspecified	0.148	0.851	0.000
O47 False labour	0.148	0.852	0.000
M24.1 Other articular cartilage disorders	0.148	0.852	0.000
M80 Osteoporosis with pathological fracture	0.148	0.852	0.000
S82.1 Fracture of upper end of tibia	0.148	0.852	0.000
Q38-Q45 Other congenital malformations of the digestive system	0.148	0.852	0.000
M81.4 Drug-induced osteoporosis	0.148	0.852	0.000
M85.8 Other specified disorders of bone density and structure	0.148	0.852	0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters	0.147	0.853	0.000
S80.8 Other superficial injuries of lower leg	0.147	0.853	0.000
O46 Antepartum haemorrhage, not elsewhere classified	0.147	0.853	0.000
Q21 Congenital malformations of cardiac septa	0.147	0.853	0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.146	0.853	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.146	0.854	0.000
S81.9 Open wound of lower leg, part unspecified	0.146	0.854	0.000
S91 Open wound of ankle and foot	0.146	0.854	0.000
M21.6 Other acquired deformities of ankle and foot	0.146	0.854	0.000
O72.0 Third-stage haemorrhage	0.145	0.855	0.000
M15 Polyarthrosis	0.145	0.855	0.000
M25.9 Joint disorder, unspecified	0.145	0.855	0.000
M25.2 Flail joint	0.145	0.855	0.000
M25.1 Fistula of joint	0.145	0.855	0.000
S83.6 Sprain and strain of other and unspecified parts of knee	0.145	0.855	0.000
S82.3 Fracture of lower end of tibia	0.144	0.856	0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.144	0.856	0.000
O64.0 Obstructed labour due to incomplete rotation of foetal head	0.144	0.856	0.000
M50.9 Cervical disk disorder, unspecified	0.144	0.856	0.000
M50.8 Other cervical disk disorders	0.144	0.856	0.000
O99.0 Anaemia complicating pregnancy, childbirth and the puerperium	0.144	0.856	0.000
A30-A49 Other bacterial diseases	0.144	0.856	0.000
S79 Other and unspecified injuries of hip and thigh	0.143	0.856	0.000
O92 Other disorders of breast and lactation associated with childbirth	0.143	0.857	0.000
O91 Infections of breast associated with childbirth	0.143	0.857	0.000
O89 Complications of anaesthesia during the puerperium	0.143	0.857	0.000
O88 Obstetric embolism	0.143	0.857	0.000
O86 Other puerperal infections	0.143	0.857	0.000
O85 Puerperal sepsis	0.143	0.857	0.000
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee	0.143	0.857	0.000
O62.2 Other uterine inertia	0.142	0.858	0.000
S82.4 Fracture of fibula alone	0.142	0.858	0.000
M22.2 Patellofemoral disorders	0.142	0.858	0.000
G25.0 Essential tremor	0.141	0.859	0.000
M25.6 Stiffness of joint, not elsewhere classified	0.141	0.859	0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.141	0.859	0.000
M81.8 Other osteoporosis	0.141	0.859	0.000
M81.6 Localised osteoporosis [Lequesne]	0.141	0.859	0.000
M81.5 Idiopathic osteoporosis	0.141	0.859	0.000
M81.3 Postsurgical malabsorption osteoporosis	0.141	0.859	0.000
M81.2 Osteoporosis of disuse	0.141	0.859	0.000
M81.1 Postoophorectomy osteoporosis	0.141	0.859	0.000
M81.0 Postmenopausal osteoporosis	0.141	0.859	0.000
O42.9 Premature rupture of membranes, unspecified	0.141	0.859	0.000
O02.1 Missed abortion	0.141	0.859	0.000
S82.5 Fracture of medial malleolus	0.141	0.859	0.000
M70 Soft tissue disorders related to use, overuse and pressure	0.141	0.859	0.000
M84.1 Nonunion of fracture [pseudarthrosis]	0.141	0.859	0.000
S90 Superficial injury of ankle and foot	0.140	0.860	0.000
M22.8 Other disorders of patella	0.140	0.860	0.000
S83.7 Injury to multiple structures of knee	0.140	0.860	0.000
S83.3 Tear of articular cartilage of knee, current	0.140	0.860	0.000
S83.1 Dislocation of knee	0.140	0.860	0.000
S83.0 Dislocation of patella	0.140	0.860	0.000
T79.3 Post-traumatic wound infection, not elsewhere classified	0.140	0.860	0.000
S82.6 Fracture of lateral malleolus	0.140	0.860	0.000
M89 Other disorders of bone	0.140	0.860	0.000
M23.0 Cystic meniscus	0.139	0.860	0.000
M65-M68 Disorders of synovium and tendon	0.139	0.861	0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle	0.139	0.861	0.000
M90 Osteopathies in diseases classified elsewhere	0.139	0.861	0.000
O99.6 Diseases of the digestive system complicating pregnancy, childbirth and the puerperium	0.139	0.861	0.000
F43.0 Acute stress reaction	0.139	0.861	0.000
G93 Other disorders of brain	0.139	0.861	0.000
M19.07 Primary arthrosis of other joints (Ankle and foot)	0.138	0.862	0.000
G00-G09 Inflammatory diseases of the central nervous system	0.138	0.862	0.000
O03 Spontaneous abortion	0.138	0.862	0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.138	0.862	0.000
Q80-Q89 Other congenital malformations	0.138	0.862	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.138	0.862	0.000
Q35-Q37 Cleft lip and cleft palate	0.138	0.862	0.000
Q30-Q34 Congenital malformations of the respiratory system	0.138	0.862	0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.138	0.862	0.000
Q00-Q07 Congenital malformations of the nervous system	0.138	0.862	0.000
F60 Specific personality disorders	0.138	0.862	0.000
Q50-Q56 Congenital malformations of genital organs	0.138	0.862	0.000
O66.5 Failed application of vacuum extractor and forceps, unspecified	0.138	0.862	0.000
T51.9 Alcohol, unspecified	0.137	0.863	0.000
O70.9 Perineal laceration during delivery, unspecified	0.137	0.863	0.000
G25.8 Other specified extrapyramidal and movement disorders	0.137	0.863	0.000
M35 Other systemic involvement of connective tissue	0.137	0.863	0.000
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.137	0.863	0.000
S72 Fracture of femur	0.137	0.863	0.000
G70-G73 Diseases of myoneural junction and muscle	0.137	0.863	0.000
G96 Other disorders of central nervous system	0.137	0.863	0.000
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.137	0.863	0.000
S80.1 Contusion of other and unspecified parts of lower leg	0.136	0.863	0.000
T23 Burn and corrosion of wrist and hand	0.136	0.863	0.000
S81.7 Multiple open wounds of lower leg	0.136	0.863	0.000
Chapter XII Diseases of the skin and subcutaneous tissue	0.137	0.863	0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes	0.136	0.864	0.000
O64.9 Obstructed labour due to malposition and malpresentation, unspecified	0.136	0.864	0.000
O64.8 Obstructed labour due to other malposition and malpresentation	0.136	0.864	0.000
O64.5 Obstructed labour due to compound presentation	0.136	0.864	0.000
O64.4 Obstructed labour due to shoulder presentation	0.136	0.864	0.000
O64.3 Obstructed labour due to brow presentation	0.136	0.864	0.000
O64.2 Obstructed labour due to face presentation	0.136	0.864	0.000
O64.1 Obstructed labour due to breech presentation	0.136	0.864	0.000
M79.6 Pain in limb	0.136	0.864	0.000
Chapter VIII Diseases of the ear and mastoid process	0.135	0.865	0.000
O62.9 Abnormality of forces of labour, unspecified	0.135	0.865	0.000
O62.8 Other abnormalities of forces of labour	0.135	0.865	0.000
O62.4 Hypertonic, incoordinate and prolonged uterine contractions	0.135	0.865	0.000
O62.3 Precipitate labour	0.135	0.865	0.000
O62.1 Secondary uterine inertia	0.135	0.865	0.000
O62.0 Primary inadequate contractions	0.135	0.865	0.000
F99-F99 Unspecified mental disorder	0.135	0.865	0.000
Q60-Q64 Congenital malformations of the urinary system	0.135	0.865	0.000
T66-T78 Other and unspecified effects of external causes	0.135	0.865	0.000
M94 Other disorders of cartilage	0.135	0.865	0.000
M19.8 Other specified arthrosis	0.135	0.865	0.000
M19.2 Other secondary arthrosis	0.135	0.865	0.000
S80.0 Contusion of knee	0.134	0.865	0.000
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral	0.134	0.865	0.000
M24.89 Other specific joint derangements, not elsewhere classified (Site unspecified)	0.134	0.866	0.000
M24.88 Other specific joint derangements, not elsewhere classified (Other)	0.134	0.866	0.000
M24.87 Other specific joint derangements, not elsewhere classified (Ankle and foot)	0.134	0.866	0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)	0.134	0.866	0.000
M24.84 Other specific joint derangements, not elsewhere classified (Hand)	0.134	0.866	0.000
M24.83 Other specific joint derangements, not elsewhere classified (Forearm)	0.134	0.866	0.000
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)	0.134	0.866	0.000
M24.81 Other specific joint derangements, not elsewhere classified (Shoulder region)	0.134	0.866	0.000
M24.80 Other specific joint derangements, not elsewhere classified (Multiple sites)	0.134	0.866	0.000
T18 Foreign body in alimentary tract	0.134	0.866	0.000
S50-S59 Injuries to the elbow and forearm	0.134	0.866	0.000
O99.7 Diseases of the skin and subcutaneous tissue complicating pregnancy, childbirth and the puerperium	0.134	0.866	0.000
O99.5 Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium	0.134	0.866	0.000
O99.4 Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium	0.134	0.866	0.000
O99.3 Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium	0.134	0.866	0.000
O99.2 Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium	0.134	0.866	0.000
O99.1 Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium	0.134	0.866	0.000
S80.7 Multiple superficial injuries of lower leg	0.134	0.866	0.000
O34.9 Maternal care for abnormality of pelvic organ, unspecified	0.134	0.866	0.000
O34.8 Maternal care for other abnormalities of pelvic organs	0.134	0.866	0.000
O34.7 Maternal care for abnormality of vulva and perineum	0.134	0.866	0.000
O34.6 Maternal care for abnormality of vagina	0.134	0.866	0.000
O34.5 Maternal care for other abnormalities of gravid uterus	0.134	0.866	0.000
O34.4 Maternal care for other abnormalities of cervix	0.134	0.866	0.000
O34.3 Maternal care for cervical incompetence	0.134	0.866	0.000
O34.1 Maternal care for tumour of corpus uteri	0.134	0.866	0.000
O34.0 Maternal care for congenital malformation of uterus	0.134	0.866	0.000
M23.4 Loose body in knee	0.134	0.866	0.000
S78 Traumatic amputation of hip and thigh	0.133	0.866	0.000
S77 Crushing injury of hip and thigh	0.133	0.866	0.000
S76 Injury of muscle and tendon at hip and thigh level	0.133	0.866	0.000
S75 Injury of blood vessels at hip and thigh level	0.133	0.866	0.000
S74 Injury of nerves at hip and thigh level	0.133	0.866	0.000
S73 Dislocation, sprain and strain of joint and ligaments of hip	0.133	0.866	0.000
O36.7 Maternal care for viable foetus in abdominal pregnancy	0.133	0.866	0.000
O36.4 Maternal care for intra-uterine death	0.133	0.866	0.000
O36.3 Maternal care for signs of foetal hypoxia	0.133	0.866	0.000
O36.2 Maternal care for hydrops foetalis	0.133	0.866	0.000
O36.1 Maternal care for other isoimmunisation	0.133	0.866	0.000
S42 Fracture of shoulder and upper arm	0.133	0.867	0.000
F43.1 Posttraumatic stress disorder	0.133	0.867	0.000
O66.9 Obstructed labour, unspecified	0.133	0.867	0.000
O66.8 Other specified obstructed labour	0.133	0.867	0.000
O66.4 Failed trial of labour, unspecified	0.133	0.867	0.000
O66.3 Obstructed labour due to other abnormalities of foetus	0.133	0.867	0.000
O66.2 Obstructed labour due to unusually large foetus	0.133	0.867	0.000
O66.1 Obstructed labour due to locked twins	0.133	0.867	0.000
O66.0 Obstructed labour due to shoulder dystocia	0.133	0.867	0.000
B20-B24 Human immunodeficiency virus [HIV] disease	0.133	0.867	0.000
M25.7 Osteophyte	0.133	0.867	0.000
S71.1 Open wound of thigh	0.133	0.867	0.000
M86 Osteomyelitis	0.132	0.867	0.000
T65 Toxic effect of other and unspecified substances	0.132	0.867	0.000
T63 Toxic effect of contact with venomous animals	0.132	0.867	0.000
T62 Toxic effect of other noxious substances eaten as food	0.132	0.867	0.000
T61 Toxic effect of noxious substances eaten as seafood	0.132	0.867	0.000
T60 Toxic effect of pesticides	0.132	0.867	0.000
T59 Toxic effect of other gases, fumes and vapours	0.132	0.867	0.000
T57 Toxic effect of other inorganic substances	0.132	0.867	0.000
T56 Toxic effect of metals	0.132	0.867	0.000
T54 Toxic effect of corrosive substances	0.132	0.867	0.000
T53 Toxic effect of halogen derivatives of aliphatic and aromatic hydrocarbone	0.132	0.867	0.000
T52 Toxic effect of organic solvents	0.132	0.867	0.000
T64 Toxic effect of aflatoxin and other mycotoxin food contaminants	0.132	0.867	0.000
T58 Toxic effect of carbon monoxide	0.132	0.867	0.000
T55 Toxic effect of soaps and detergents	0.132	0.867	0.000
C15-C26 Malignant neoplasms of digestive organs	0.133	0.867	0.000
S82.9 Fracture of lower leg, part unspecified	0.132	0.868	0.000
S82.7 Multiple fractures of lower leg	0.132	0.868	0.000
C79 Secondary malignant neoplasm of other sites	0.132	0.868	0.000
Q27 Other congenital malformations of peripheral vascular system	0.132	0.868	0.000
S12 Fracture of neck	0.132	0.868	0.000
O08 Complications following abortion and ectopic and molar pregnancy	0.131	0.868	0.000
O07 Failed attempted abortion	0.131	0.868	0.000
O06 Unspecified abortion	0.131	0.868	0.000
O05 Other abortion	0.131	0.868	0.000
O01 Hydatidiform mole	0.131	0.868	0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma	0.132	0.868	0.000
M76 Enthesopathies of lower limb, excluding foot	0.131	0.869	0.000
M73 Soft tissue disorders in diseases classified elsewhere	0.131	0.869	0.000
S70 Superficial injury of hip and thigh	0.131	0.869	0.000
G95 Other diseases of spinal cord	0.131	0.869	0.000
B95.4 Other streptococcus as the cause of diseases classified to other chapters	0.131	0.869	0.000
M19.96 Arthrosis, unspecified-Lower leg	0.131	0.869	0.000
S89.8 Other specified injuries of lower leg	0.131	0.869	0.000
S89.7 Multiple injuries of lower leg	0.131	0.869	0.000
S89.1 Other specified injuries of lower leg	0.131	0.869	0.000
S89.0 Multiple injuries of lower leg	0.131	0.869	0.000
S81.0 Open wound of knee	0.131	0.869	0.000
M18.5 Other secondary arthrosis of first carpometacarpal joint	0.131	0.869	0.000
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral	0.131	0.869	0.000
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint	0.131	0.869	0.000
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral	0.131	0.869	0.000
M93 Other osteochondropathies	0.131	0.869	0.000
G23 Other degenerative diseases of basal ganglia	0.130	0.869	0.000
G21 Secondary Parkinsonism	0.130	0.869	0.000
G26 Extrapyramidal and movement disorders in diseases classified elsewhere	0.130	0.869	0.000
G22 Parkinsonism in diseases classified elsewhere	0.130	0.869	0.000
G80-G83 Cerebral palsy and other paralytic syndromes	0.130	0.869	0.000
O60.3 Preterm delivery without spontaneous labour	0.130	0.870	0.000
O60.2 Preterm spontaneous labour with term delivery	0.130	0.870	0.000
O60.1 Preterm spontaneous labour with preterm delivery	0.130	0.870	0.000
O60.0 Preterm labour without delivery	0.130	0.870	0.000
O61.9 Failed induction of labour, unspecified	0.130	0.870	0.000
O61.8 Other failed induction of labour	0.130	0.870	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations