TreeWAS – Variant ID: rs17421899

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability
C44.6 Skin of upper limb, including shoulder	1.000	0.000
C44.3 Skin of other and unspecified parts of face	1.000	0.000
C44 Other malignant neoplasms of skin	1.000	0.000
M20 Acquired deformities of fingers and toes	1.000	0.000
C43-C44 Melanoma and other malignant neoplasms of skin	1.000	0.000
L80-L99 Other disorders of the skin and subcutaneous tissue	1.000	0.000
Chapter XII Diseases of the skin and subcutaneous tissue	1.000	0.000
C43 Malignant melanoma of skin	1.000	0.000
C44.5 Skin of trunk	1.000	0.000
M20.1 Hallux valgus (acquired)	1.000	0.000
M20-M25 Other joint disorders	1.000	0.000
Chapter II Neoplasms	1.000	0.000
L90.5 Scar conditions and fibrosis of skin	1.000	0.000
L90 Atrophic disorders of skin	1.000	0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.999	0.001
C44.4 Skin of scalp and neck	0.999	0.001
L57 Skin changes due to chronic exposure to nonionising radiation	0.999	0.001
L57.0 Actinic keratosis	0.999	0.001
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.999	0.001
C44.1 Skin of eyelid, including canthus	0.999	0.001
L72.1 Trichilemmal cyst	0.997	0.003
M23 Internal derangement of knee	0.997	0.003
L60-L75 Disorders of skin appendages	0.997	0.003
L72 Follicular cysts of skin and subcutaneous tissue	0.997	0.003
L81 Other disorders of pigmentation	0.995	0.005
Z85.8 Personal history of malignant neoplasms of other organs and systems	0.995	0.005
C43.5 Malignant melanoma of trunk	0.995	0.005
M23.2 Derangement of meniscus due to old tear or injury	0.993	0.007
M20.4 Other hammer toe(s) (acquired)	0.992	0.008
C43.6 Malignant melanoma of upper limb, including shoulder	0.991	0.009
L81.4 Other melanin hyperpigmentation	0.989	0.011
D00-D09 In situ neoplasms	0.986	0.014
D03 Melanoma in situ	0.983	0.017
M23.23 Derangement of meniscus due to old tear or injury (Medial collateral ligament or Other and unspecified medial meniscus)	0.983	0.017
# Top node	0.980	0.020
C44.7 Skin of lower limb, including hip	0.979	0.021
C44.2 Skin of ear and external auricular canal	0.975	0.025
D37-D48 Neoplasms of uncertain or unknown behaviour	0.975	0.025
M23.21 Derangement of meniscus due to old tear or injury (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.973	0.027
L85 Other epidermal thickening	0.972	0.028
M80-M85 Disorders of bone density and structure	0.971	0.029
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.971	0.029
D03.5 Melanoma in situ of trunk	0.961	0.039
C71 Malignant neoplasm of brain	0.953	0.047
D46 Myelodysplastic syndromes	0.953	0.047
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.950	0.050
C64-C68 Malignant neoplasms of urinary tract	0.946	0.054
M86-M90 Other osteopathies	0.929	0.071
L85.8 Other specified epidermal thickening	0.928	0.072
Chapter XX External causes of morbidity and mortality	0.925	0.075
Q38-Q45 Other congenital malformations of the digestive system	0.921	0.079
D03.6 Melanoma in situ of upper limb, including shoulder	0.917	0.083
M84 Disorders of continuity of bone	0.916	0.084
C71.9 Brain, unspecified	0.916	0.084
M20.0 Deformity of finger(s)	0.911	0.089
M40-M43 Deforming dorsopathies	0.909	0.091
C44.0 Skin of lip	0.908	0.092
M23.8 Other internal derangements of knee	0.906	0.094
M80 Osteoporosis with pathological fracture	0.906	0.094
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.905	0.095
L81.8 Other specified disorders of pigmentation	0.905	0.095
M23.26 Derangement of meniscus due to old tear or injury (Other and unspecified lateral meniscus)	0.901	0.099
D46.9 Myelodysplastic syndrome, unspecified	0.899	0.101
C43.4 Malignant melanoma of scalp and neck	0.889	0.111
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.889	0.111
Y85-Y89 Sequelae of external causes of morbidity and mortality	0.888	0.112
D41 Neoplasm of uncertain or unknown behaviour of urinary organs	0.885	0.115
M60-M63 Disorders of muscles	0.885	0.115
M84.1 Nonunion of fracture [pseudarthrosis]	0.875	0.125
L89 Decubitus ulcer	0.869	0.131
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.865	0.135
C43.3 Malignant melanoma of other and unspecified parts of face	0.865	0.135
Q38 Other congenital malformations of tongue, mouth and pharynx	0.857	0.143
M45-M49 Spondylopathies	0.847	0.153
M00-M03 Infectious arthropathies	0.847	0.153
Y52 Agents primarily affecting the cardiovascular system	0.844	0.156
C40-C41 Malignant neoplasms of bone and articular cartilage	0.844	0.156
M80.9 Unspecified osteoporosis with pathological fracture	0.837	0.163
C50-C50 Malignant neoplasm of breast	0.834	0.166
Q66 Congenital deformities of feet	0.832	0.168
D04 Carcinoma in situ of skin	0.832	0.168
L85.9 Epidermal thickening, unspecified	0.829	0.171
C71.0 Cerebrum, except lobes and ventricles	0.827	0.173
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system	0.819	0.181
L98 Other disorders of skin and subcutaneous tissue, not elsewhere classified	0.817	0.183
M88 Paget's disease of bone [osteitis deformans]	0.817	0.183
C67 Malignant neoplasm of bladder	0.814	0.186
M20.6 Acquired deformity of toe(s), unspecified	0.814	0.186
M24 Other specific joint derangements	0.814	0.186
Q38.7 Pharyngeal pouch	0.811	0.189
C43.1 Malignant melanoma of eyelid, including canthus	0.810	0.190
M23.0 Cystic meniscus	0.807	0.193
D03.3 Melanoma in situ of other and unspecified parts of face	0.806	0.194
D46.4 Refractory anaemia, unspecified	0.805	0.195
M23.5 Chronic instability of knee	0.805	0.195
C43.9 Malignant melanoma of skin, unspecified	0.804	0.196
M84.17 Nonunion of fracture [pseudarthrosis] (Ankle and foot)	0.802	0.198
Y85 Sequelae of transport accidents	0.799	0.201
D46.2 Refractory anaemia with excess of blasts	0.795	0.204
M87 Osteonecrosis	0.795	0.205
L70 Acne	0.792	0.208
L82 Seborrhoeic keratosis	0.792	0.208
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.792	0.208
D03.4 Melanoma in situ of scalp and neck	0.791	0.209
C64 Malignant neoplasm of kidney, except renal pelvis	0.789	0.211
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.786	0.214
L81.2 Freckles	0.782	0.218
M80.98 Unspecified osteoporosis with pathological fracture (Other)	0.781	0.219
C97-C97 Malignant neoplasms of independent (primary) multiple sites	0.780	0.219
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.780	0.220
L72.8 Other follicular cysts of skin and subcutaneous tissue	0.779	0.221
M62 Other disorders of muscle	0.779	0.221
L50-L54 Urticaria and erythema	0.775	0.225
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified	0.773	0.227
L89.0 Stage I decubitus ulcer and pressure area	0.772	0.228
C73-C75 Malignant neoplasms of thyroid and other endocrine glands	0.772	0.228
C66 Malignant neoplasm of ureter	0.772	0.228
M22 Disorders of patella	0.772	0.228
M40 Kyphosis and lordosis	0.771	0.229
L83 Acanthosis nigricans	0.771	0.229
M43 Other deforming dorsopathies	0.771	0.229
C43.7 Malignant melanoma of lower limb, including hip	0.771	0.229
Q44 Congenital malformations of gallbladder, bile ducts and liver	0.769	0.231
Y52.5 Other antihypertensive drugs, not elsewhere classified	0.768	0.232
Q66.8 Other congenital deformities of feet	0.767	0.233
M23.80 Other internal derangements of knee (Multiple sites)	0.764	0.236
Y60-Y69 Misadventures to patients during surgical and medical care	0.762	0.238
D41.0 Kidney	0.756	0.244
L89.1 Stage II decubitus ulcer	0.755	0.245
Chapter VII Diseases of the eye and adnexa	0.755	0.245
Q76 Congenital malformations of spine and bony thorax	0.753	0.247
M48 Other spondylopathies	0.753	0.247
M32 Systemic lupus erythematosus	0.752	0.248
M91-M94 Chondropathies	0.751	0.249
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.750	0.250
D03.2 Melanoma in situ of ear and external auricular canal	0.749	0.251
X20-X29 Contact with venomous animals and plants	0.748	0.252
C44.9 Malignant neoplasm of skin, unspecified	0.747	0.252
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue	0.746	0.254
C71.4 Occipital lobe	0.744	0.256
M21 Other acquired deformities of limbs	0.744	0.256
L98.4 Chronic ulcer of skin, not elsewhere classified	0.743	0.256
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified	0.742	0.258
C65 Malignant neoplasm of renal pelvis	0.740	0.260
X10-X19 Contact with heat and hot substances	0.739	0.260
M00 Pyogenic arthritis	0.739	0.261
D41.4 Bladder	0.738	0.262
M23.1 Discoid meniscus (congenital)	0.737	0.263
M88.9 Paget's disease of bone, unspecified	0.736	0.264
L85.1 Acquired keratosis [keratoderma] palmaris et plantaris	0.736	0.264
X58-X59 Accidental exposure to other and unspecified factors	0.735	0.265
C41 Malignant neoplasm of bone and articular cartilage of other and unspecified sites	0.732	0.268
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent	0.731	0.269
M84.13 Nonunion of fracture [pseudarthrosis] (Forearm)	0.731	0.269
L10-L14 Bullous disorders	0.729	0.271
H53-H54 Visual disturbances and blindness	0.727	0.273
M90 Osteopathies in diseases classified elsewhere	0.725	0.275
C71.2 Temporal lobe	0.725	0.275
Q43 Other congenital malformations of intestine	0.725	0.275
M84.4 Pathological fracture, not elsewhere classified	0.725	0.275
M23.24 Derangement of meniscus due to old tear or injury (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.725	0.275
M48.5 Collapsed vertebra, not elsewhere classified	0.724	0.276
M46 Other inflammatory spondylopathies	0.724	0.276
Y89 Sequelae of other external causes	0.723	0.276
M24.1 Other articular cartilage disorders	0.723	0.277
M84.2 Delayed union of fracture	0.722	0.278
H53 Visual disturbances	0.721	0.279
L57.8 Other skin changes due to chronic exposure to nonionising radiation	0.721	0.279
M23.4 Loose body in knee	0.720	0.280
W75-W84 Other accidental threats to breathing	0.719	0.281
D46.7 Other myelodysplastic syndromes	0.718	0.282
Y88 Sequelae of surgical and medical care as external cause	0.718	0.282
C44.8 Overlapping lesion of skin	0.717	0.283
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere	0.717	0.283
L87 Transepidermal elimination disorders	0.717	0.283
L88 Pyoderma gangrenosum	0.717	0.283
L86 Keratoderma in diseases classified elsewhere	0.717	0.283
C43.8 Overlapping malignant melanoma of skin	0.717	0.283
C43.2 Malignant melanoma of ear and external auricular canal	0.717	0.283
C43.0 Malignant melanoma of lip	0.717	0.283
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.717	0.283
Y46 Antiepileptics and anti-Parkinsonism drugs	0.717	0.283
L90.9 Atrophic disorder of skin, unspecified	0.717	0.283
L90.8 Other atrophic disorders of skin	0.717	0.283
L90.6 Striae atrophicae	0.717	0.283
L90.4 Acrodermatitis chronica atrophicans	0.717	0.283
L90.3 Atrophoderma of Pasini and Pierini	0.717	0.283
L90.2 Anetoderma of Jadassohn-Pellizzari	0.717	0.283
L90.1 Anetoderma of Schweninger-Buzzi	0.717	0.283
Y48 Anaesthetics and therapeutic gases	0.717	0.283
L59 Other disorders of skin and subcutaneous tissue related to radiation	0.716	0.283
L58 Radiodermatitis	0.716	0.283
L55 Sunburn	0.716	0.283
M84.16 Nonunion of fracture [pseudarthrosis] (Lower leg)	0.716	0.284
L57.5 Actinic granuloma	0.716	0.284
L57.4 Cutis laxa senilis	0.716	0.284
L57.3 Poikiloderma of Civatte	0.716	0.284
L57.2 Cutis rhomboidalis nuchae	0.716	0.284
L57.1 Actinic reticuloid	0.716	0.284
D39 Neoplasm of uncertain or unknown behaviour of female genital organs	0.716	0.284
C50 Malignant neoplasm of breast	0.716	0.284
L75 Apocrine sweat disorders	0.715	0.285
L74 Eccrine sweat disorders	0.715	0.285
L68 Hypertrichosis	0.715	0.285
L67 Hair colour and hair shaft abnormalities	0.715	0.285
L66 Cicatricial alopecia [scarring hair loss]	0.715	0.285
L64 Androgenic alopecia	0.715	0.285
L63 Alopecia areata	0.715	0.285
L62 Nail disorders in diseases classified elsewhere	0.715	0.285
L72.2 Steatocystoma multiplex	0.714	0.285
Y45.2 Propionic acid derivatives	0.715	0.285
M30 Polyarteritis nodosa and related conditions	0.714	0.286
M80.0 Postmenopausal osteoporosis with pathological fracture	0.714	0.286
L81.7 Pigmented purpuric dermatosis	0.714	0.286
L81.6 Other disorders of diminished melanin formation	0.714	0.286
L81.5 Leukoderma, not elsewhere classified	0.714	0.286
L81.3 Cafe au lait spots	0.714	0.286
L81.1 Chloasma	0.714	0.286
L81.0 Postinflammatory hyperpigmentation	0.714	0.286
M20.5 Other deformities of toe(s) (acquired)	0.714	0.286
Y00-Y09 Assault	0.713	0.286
M23.27 Derangement of meniscus due to old tear or injury-Capsular	0.712	0.288
M23.59 Chronic instability of knee (Unspecified ligament or Unspecified meniscus)	0.711	0.289
C71.3 Parietal lobe	0.711	0.289
C13 Malignant neoplasm of hypopharynx	0.710	0.290
M84.14 Nonunion of fracture [pseudarthrosis] (Hand)	0.709	0.291
Q80-Q89 Other congenital malformations	0.708	0.291
Y85.9 Sequelae of other and unspecified transport accidents	0.708	0.292
Q39 Congenital malformations of oesophagus	0.707	0.293
D01 Carcinoma in situ of other and unspecified digestive organs	0.707	0.293
D03.9 Melanoma in situ, unspecified	0.705	0.295
D03.8 Melanoma in situ of other sites	0.705	0.295
D03.1 Melanoma in situ of eyelid, including canthus	0.705	0.295
D03.0 Melanoma in situ of lip	0.705	0.295
D00 Carcinoma in situ of oral cavity, oesophagus and stomach	0.704	0.296
Chapter XVI Certain conditions originating in the perinatal period	0.702	0.297
L56 Other acute skin changes due to ultraviolet radiation	0.700	0.299
M23.6 Other spontaneous disruption of ligament(s) of knee	0.700	0.300
M23.82 Other internal derangements of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.699	0.300
D42 Neoplasm of uncertain or unknown behaviour of meninges	0.699	0.301
H53.8 Other visual disturbances	0.698	0.302
M43.1 Spondylolisthesis	0.698	0.302
L85.3 Xerosis cutis	0.697	0.303
L85.2 Keratosis punctata (palmaris et plantaris)	0.697	0.303
L85.0 Acquired ichthyosis	0.697	0.303
M83 Adult osteomalacia	0.696	0.303
C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system	0.696	0.304
C70 Malignant neoplasm of meninges	0.696	0.304
Y52.4 Angiotensin-converting-enzyme inhibitors	0.695	0.305
M60 Myositis	0.695	0.305
C50.2 Upper-inner quadrant of breast	0.695	0.305
C67.8 Overlapping lesion of bladder	0.695	0.305
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.694	0.306
D45 Polycythaemia vera	0.694	0.306
M89 Other disorders of bone	0.692	0.308
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx	0.691	0.309
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs	0.689	0.311
M85 Other disorders of bone density and structure	0.689	0.311
M22.8 Other disorders of patella	0.687	0.313
C67.5 Bladder neck	0.686	0.314
C04 Malignant neoplasm of floor of mouth	0.686	0.314
M41 Scoliosis	0.686	0.314
L95 Vasculitis limited to skin, not elsewhere classified	0.686	0.314
M62.8 Other specified disorders of muscle	0.685	0.315
L98.1 Factitial dermatitis	0.684	0.316
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified	0.684	0.316
C71.8 Overlapping lesion of brain	0.684	0.316
C71.7 Brain stem	0.684	0.316
C71.6 Cerebellum	0.684	0.316
C71.5 Cerebral ventricle	0.684	0.316
D46.6 Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality	0.683	0.316
D46.5 Refractory anaemia with multi-lineage dysplasia	0.683	0.316
D46.3 Refractory anaemia with excess of blasts with transformation	0.683	0.316
D46.1 Refractory anaemia with sideroblasts	0.683	0.316
D46.0 Refractory anaemia without sideroblasts, so stated	0.683	0.316
Q40 Other congenital malformations of upper alimentary tract	0.683	0.317
Y51 Drugs primarily affecting the autonomic nervous system	0.683	0.317
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.682	0.318
Q35-Q37 Cleft lip and cleft palate	0.681	0.319
Q30-Q34 Congenital malformations of the respiratory system	0.681	0.319
M80.1 Postoophorectomy osteoporosis with pathological fracture	0.681	0.319
Q50-Q56 Congenital malformations of genital organs	0.680	0.320
C48 Malignant neoplasm of retroperitoneum and peritoneum	0.680	0.320
L60 Nail disorders	0.679	0.321
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.679	0.321
Q67 Congenital musculoskeletal deformities of head, face, spine and chest	0.678	0.321
C68 Malignant neoplasm of other and unspecified urinary organs	0.678	0.322
L50 Urticaria	0.676	0.324
D41.2 Ureter	0.675	0.325
L00-L08 Infections of the skin and subcutaneous tissue	0.673	0.327
M40.2 Other and unspecified kyphosis	0.673	0.327
D04.4 Skin of scalp and neck	0.672	0.328
Y47 Sedatives, hypnotics and antianxiety drugs	0.672	0.328
Y52.3 Coronary vasodilators, not elsewhere classified	0.672	0.328
M23.83 Other internal derangements of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.671	0.328
C67.6 Ureteric orifice	0.670	0.330
M23.04 Cystic meniscus (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.670	0.330
Y42.7 Androgens and anabolic congeners	0.670	0.330
D04.3 Skin of other and unspecified parts of face	0.668	0.332
H00-H06 Disorders of eyelid, lacrimal system and orbit	0.668	0.332
Q76.4 Other congenital malformations of spine, not associated with scoliosis	0.668	0.332
D04.2 Skin of ear and external auricular canal	0.667	0.333
D43.2 Brain, unspecified	0.666	0.334
M22.9 Disorder of patella, unspecified	0.665	0.335
Y44 Agents primarily affecting blood constituents	0.665	0.335
H53.4 Visual field defects	0.665	0.335
C12 Malignant neoplasm of pyriform sinus	0.665	0.335
C08 Malignant neoplasm of other and unspecified major salivary glands	0.664	0.336
Y35-Y36 Legal intervention and operations of war	0.663	0.337
Y10-Y34 Event of undetermined intent	0.663	0.337
X85-X99 Assault	0.663	0.337
X30-X39 Exposure to forces of nature	0.663	0.337
X00-X09 Exposure to smoke, fire and flames	0.663	0.337
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.663	0.337
W65-W74 Accidental drowning and submersion	0.663	0.337
V95-V97 Air and space transport accidents	0.663	0.337
V90-V94 Water transport accidents	0.663	0.337
V70-V79 Bus occupant injured in transport accident	0.663	0.337
V60-V69 Occupant of heavy transport vehicle injured in transport accident	0.663	0.337
V50-V59 Occupant of pick-up truck or van injured in transport accident	0.663	0.337
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident	0.663	0.337
H30-H36 Disorders of choroid and retina	0.662	0.338
M81 Osteoporosis without pathological fracture	0.661	0.339
D07 Carcinoma in situ of other and unspecified genital organs	0.661	0.339
V98-V99 Other and unspecified transport accidents	0.661	0.339
C00 Malignant neoplasm of lip	0.661	0.339
M00.9 Pyogenic arthritis, unspecified	0.661	0.339
M34 Systemic sclerosis	0.661	0.339
Q45 Other congenital malformations of digestive system	0.660	0.340
Q42 Congenital absence, atresia and stenosis of large intestine	0.660	0.340
Q41 Congenital absence, atresia and stenosis of small intestine	0.660	0.340
D43.1 Brain, infratentorial	0.660	0.340
Q44.6 Cystic disease of liver	0.660	0.340
M88.90 Paget's disease of bone, unspecified (Multiple sites)	0.660	0.340
C69 Malignant neoplasm of eye and adnexa	0.659	0.341
M23.29 Derangement of meniscus due to old tear or injury (Unspecified ligament or Unspecified meniscus)	0.659	0.341
M33 Dermatopolymyositis	0.659	0.341
M23.9 Internal derangement of knee, unspecified	0.659	0.341
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system	0.658	0.342
L65 Other nonscarring hair loss	0.657	0.343
M84.9 Disorder of continuity of bone, unspecified	0.657	0.343
M84.8 Other disorders of continuity of bone	0.657	0.343
M84.3 Stress fracture, not elsewhere classified	0.657	0.343
M84.12 Nonunion of fracture [pseudarthrosis] (Upper arm)	0.656	0.344
M21.6 Other acquired deformities of ankle and foot	0.656	0.344
C11 Malignant neoplasm of nasopharynx	0.656	0.344
V01-V09 Pedestrian injured in transport accident	0.654	0.346
D04.6 Skin of upper limb, including shoulder	0.654	0.346
M87.9 Osteonecrosis, unspecified	0.654	0.346
H34 Retinal vascular occlusions	0.654	0.346
L98.9 Disorder of skin and subcutaneous tissue, unspecified	0.653	0.347
D09 Carcinoma in situ of other and unspecified sites	0.652	0.348
M42 Spinal osteochondrosis	0.652	0.348
M23.87 Other internal derangements of knee (Capsular ligament)	0.650	0.350
M23.86 Other internal derangements of knee (Other and unspecified lateral meniscus)	0.650	0.350
M23.85 Other internal derangements of knee (Posterior horn of lateral meniscus)	0.650	0.350
M23.84 Other internal derangements of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.650	0.350
M80.8 Other osteoporosis with pathological fracture	0.649	0.350
M80.4 Drug-induced osteoporosis with pathological fracture	0.649	0.350
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.649	0.350
M80.2 Osteoporosis of disuse with pathological fracture	0.649	0.350
Q78 Other osteochondrodysplasias	0.649	0.351
Q77 Osteochondrodysplasia with defects of growth of tubular bones and spine	0.649	0.351
Q75 Other congenital malformations of skull and face bones	0.649	0.351
Q74 Other congenital malformations of limb(s)	0.649	0.351
Q73 Reduction defects of unspecified limb	0.649	0.351
Q72 Reduction defects of lower limb	0.649	0.351
Q71 Reduction defects of upper limb	0.649	0.351
Q70 Syndactyly	0.649	0.351
Q69 Polydactyly	0.649	0.351
Q68 Other congenital musculoskeletal deformities	0.649	0.351
Y49 Psychotropic drugs, not elsewhere classified	0.649	0.351
M50-M54 Other dorsopathies	0.647	0.353
L94 Other localised connective tissue disorders	0.646	0.354
M49 Spondylopathies in diseases classified elsewhere	0.645	0.355
L70.0 Acne vulgaris	0.645	0.355
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands	0.645	0.355
M48.54 Collapsed vertebra, not elsewhere classified (Thoracic region)	0.644	0.356
L93 Lupus erythematosus	0.643	0.357
C10 Malignant neoplasm of oropharynx	0.643	0.357
L89.3 Stage IV decubitus ulcer	0.643	0.357
L08 Other local infections of skin and subcutaneous tissue	0.643	0.357
L20-L30 Dermatitis and eczema	0.643	0.357
M80.5 Idiopathic osteoporosis with pathological fracture	0.642	0.357
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites	0.642	0.358
W50-W64 Exposure to animate mechanical forces	0.641	0.359
Q66.7 Pes cavus	0.641	0.359
Y85.0 Sequelae of motor-vehicle accident	0.640	0.360
Y59 Other and unspecified vaccines and biological substances	0.637	0.362
Y58 Bacterial vaccines	0.637	0.362
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.637	0.362
Y50 Central nervous system stimulants, not elsewhere classified	0.637	0.362
D47.2 Monoclonal gammopathy	0.637	0.363
C01 Malignant neoplasm of base of tongue	0.636	0.364
D41.9 Urinary organ, unspecified	0.635	0.365
D41.7 Other urinary organs	0.635	0.365
D41.3 Urethra	0.635	0.365
D41.1 Renal pelvis	0.635	0.365
M63 Disorders of muscle in diseases classified elsewhere	0.635	0.365
M61 Calcification and ossification of muscle	0.635	0.365
L84 Corns and callosities	0.633	0.367
L90.0 Lichen sclerosus et atrophicus	0.633	0.367
V20-V29 Motorcycle rider injured in transport accident	0.632	0.368
C05 Malignant neoplasm of palate	0.632	0.368
M24.8 Other specific joint derangements, not elsewhere classified	0.631	0.369
Y41 Other systemic anti-infectives and antiparasitics	0.630	0.369
M23.09 Cystic meniscus (Unspecified ligament or Unspecified meniscus)	0.629	0.371
Y60 Unintentional cut, puncture, perforation or haemorrhage during surgical and medical care	0.629	0.371
H34.2 Other retinal artery occlusions	0.628	0.371
M84.19 Nonunion of fracture [pseudarthrosis] (Site unspecified)	0.627	0.373
M84.18 Nonunion of fracture [pseudarthrosis] (Other)	0.627	0.373
M84.10 Nonunion of fracture [pseudarthrosis] (Multiple sites)	0.627	0.373
D40 Neoplasm of uncertain or unknown behaviour of male genital organs	0.626	0.373
Q79.6 Ehlers-Danlos syndrome	0.624	0.376
M43.17 Spondylolisthesis (Lumbosacral region)	0.624	0.376
M84.11 Nonunion of fracture [pseudarthrosis] (Shoulder region)	0.624	0.376
M65-M68 Disorders of synovium and tendon	0.623	0.376
C97 Malignant neoplasms of independent (primary) multiple sites	0.623	0.377
Q66.2 Metatarsus varus	0.623	0.377
M48.56 Collapsed vertebra, not elsewhere classified (Lumbar region)	0.623	0.377
X23 Contact with hornets, wasps and bees	0.621	0.379
C06 Malignant neoplasm of other and unspecified parts of mouth	0.620	0.379
C03 Malignant neoplasm of gum	0.620	0.379
L98.5 Mucinosis of skin	0.620	0.380
C73 Malignant neoplasm of thyroid gland	0.620	0.380
H53.9 Visual disturbance, unspecified	0.620	0.380
L71 Rosacea	0.619	0.381
M82 Osteoporosis in diseases classified elsewhere	0.618	0.382
C67.0 Trigone of bladder	0.618	0.382
C71.1 Frontal lobe	0.617	0.382
Y86 Sequelae of other accidents	0.617	0.383
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)	0.617	0.383
L08.9 Local infection of skin and subcutaneous tissue, unspecified	0.616	0.384
M24.2 Disorder of ligament	0.616	0.384
Q43.0 Meckel's diverticulum	0.615	0.385
C67.1 Dome of bladder	0.615	0.385
Q38.8 Other congenital malformations of pharynx	0.614	0.386
Q38.6 Other congenital malformations of mouth	0.614	0.386
Q38.5 Congenital malformations of palate, not elsewhere classified	0.614	0.386
Q38.4 Congenital malformations of salivary glands and ducts	0.614	0.386
Q38.3 Other congenital malformations of tongue	0.614	0.386
Q38.2 Macroglossia	0.614	0.386
Q38.1 Ankyloglossia	0.614	0.386
Q38.0 Congenital malformations of lips, not elsewhere classified	0.614	0.386
D03.7 Melanoma in situ of lower limb, including hip	0.614	0.386
X60-X84 Intentional self-harm	0.613	0.387
M20.2 Hallux rigidus	0.613	0.387
M87.2 Osteonecrosis due to previous trauma	0.613	0.387
M46.2 Osteomyelitis of vertebra	0.612	0.387
M51 Other intervertebral disk disorders	0.612	0.388
Y52.1 Calcium-channel blockers	0.610	0.389
M24.11 Other articular cartilage disorders (Shoulder region)	0.610	0.390
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.607	0.392
M02 Reactive arthropathies	0.607	0.392
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.607	0.392
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)	0.607	0.393
M94 Other disorders of cartilage	0.607	0.393
Y48.2 Other and unspecified general anaesthetics	0.607	0.393
X10 Contact with hot drinks, food, fats and cooking oils	0.606	0.393
M25 Other joint disorders, not elsewhere classified	0.606	0.394
M87.8 Other osteonecrosis	0.606	0.394
Y57 Other and unspecified drugs and medicaments	0.606	0.394
Y89.9 Sequelae of unspecified external cause	0.606	0.394
Y52.8 Antivaricose drugs, including sclerosing agents	0.605	0.395
Y52.7 Peripheral vasodilators	0.605	0.395
Y52.0 Cardiac-stimulant glycosides and drugs of similar action	0.605	0.395
C42 hematopoietic and reticuloendothelial systems (ICD-O-3 specific)	0.605	0.395
C40 Malignant neoplasm of bone and articular cartilage of limbs	0.605	0.395
W00-W19 Falls	0.605	0.395
M43.6 Torticollis	0.603	0.397
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.603	0.397
M24.4 Recurrent dislocation and subluxation of joint	0.603	0.397
H04 Disorders of lachrymal system	0.603	0.397
V80-V89 Other land transport accidents	0.602	0.398
H02 Other disorders of eyelid	0.601	0.399
X59 Exposure to unspecified factor	0.601	0.399
M86 Osteomyelitis	0.600	0.400
M80.97 Unspecified osteoporosis with pathological fracture (Ankle and foot)	0.600	0.400
M80.96 Unspecified osteoporosis with pathological fracture (Lower leg)	0.600	0.400
M80.95 Unspecified osteoporosis with pathological fracture (Pelvic region and thigh)	0.600	0.400
M80.94 Unspecified osteoporosis with pathological fracture (Hand)	0.600	0.400
M80.93 Unspecified osteoporosis with pathological fracture (Forearm)	0.600	0.400
M80.92 Unspecified osteoporosis with pathological fracture (Upper arm)	0.600	0.400
M80.91 Unspecified osteoporosis with pathological fracture (Shoulder region)	0.600	0.400
C13.9 Hypopharynx, unspecified	0.599	0.401
M45 Ankylosing spondylitis	0.598	0.402
Q66.9 Congenital deformity of feet, unspecified	0.597	0.403
Q66.6 Other congenital valgus deformities of feet	0.597	0.403
Q66.5 Congenital pes planus	0.597	0.403
Q66.4 Talipes calcaneovalgus	0.597	0.403
Q66.1 Talipes calcaneovarus	0.597	0.403
Q66.0 Talipes equinovarus	0.597	0.403
M48.9 Spondylopathy, unspecified	0.597	0.403
D04.9 Skin, unspecified	0.597	0.403
D04.8 Skin of other sites	0.597	0.403
D04.1 Skin of eyelid, including canthus	0.597	0.403
D04.0 Skin of lip	0.597	0.403
Y88.3 Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient or of later complication, without mention of misadventure at the time of the procedure	0.596	0.404
D02 Carcinoma in situ of middle ear and respiratory system	0.595	0.404
M21.67 Other acquired deformities of ankle and foot-Ankle/foot	0.593	0.407

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations