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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs17423218
log Bayes Factor = 17.6829
Chromosome 8   position 67,758,401  (GRCh37) Explore rs17423218 on Ensembl!
Variant rs17423218 is part of Cluster X0122

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter XI Diseases of the digestive system
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
K70-K77 Diseases of liver
0.999 0.001 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.994 0.006 0.000
Chapter V Mental and behavioural disorders
0.993 0.007 0.000
E10-E14 Diabetes mellitus
0.991 0.009 0.000
M50-M54 Other dorsopathies
0.989 0.011 0.000
M20-M25 Other joint disorders
0.987 0.013 0.000
Chapter VI Diseases of the nervous system
0.987 0.013 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.986 0.014 0.000
E11 Non-insulin-dependent diabetes mellitus
0.986 0.014 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.981 0.019 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.981 0.019 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.981 0.019 0.000
I10-I15 Hypertensive diseases
0.980 0.020 0.000
Chapter XXI Factors influencing health status and contact with health services
0.972 0.028 0.000
Z00-Z13 Persons encountering health services for examination and investigation
0.971 0.029 0.000
K76 Other diseases of liver
0.967 0.033 0.000
I10 Essential (primary) hypertension
0.967 0.033 0.000
M45-M49 Spondylopathies
0.967 0.033 0.000
Z03 Medical observation and evaluation for suspected diseases and conditions
0.963 0.037 0.000
E11.9 Without complications
0.960 0.040 0.000
K70 Alcoholic liver disease
0.957 0.043 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.951 0.049 0.000
I30-I52 Other forms of heart disease
0.943 0.057 0.000
M54 Dorsalgia
0.941 0.059 0.000
F10 Mental and behavioural disorders due to use of alcohol
0.941 0.059 0.000
Z03.4 Observation for suspected myocardial infarction
0.937 0.063 0.000
K04 Diseases of pulp and periapical tissues
0.936 0.064 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.935 0.065 0.000
K20-K31 Diseases of oesophagus, stomach and duodenum
0.933 0.067 0.000
M47 Spondylosis
0.930 0.070 0.000
K76.6 Portal hypertension
0.930 0.070 0.000
Chapter VII Diseases of the eye and adnexa
0.930 0.070 0.000
I05-I09 Chronic rheumatic heart diseases
0.928 0.072 0.000
F10.0 Acute intoxication
0.922 0.078 0.000
K29 Gastritis and duodenitis
0.922 0.078 0.000
M25 Other joint disorders, not elsewhere classified
0.921 0.079 0.000
F17 Mental and behavioural disorders due to use of tobacco
0.920 0.080 0.000
M23 Internal derangement of knee
0.917 0.083 0.000
G40-G47 Episodic and paroxysmal disorders
0.911 0.089 0.000
Chapter XIV Diseases of the genitourinary system
0.908 0.092 0.000
I60-I69 Cerebrovascular diseases
0.901 0.099 0.000
K74 Fibrosis and cirrhosis of liver
0.900 0.100 0.000
K14 Diseases of tongue
0.896 0.104 0.000
Chapter VIII Diseases of the ear and mastoid process
0.892 0.108 0.000
F30-F39 Mood [affective] disorders
0.892 0.108 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.889 0.111 0.000
M47.8 Other spondylosis
0.889 0.111 0.000
K08 Other disorders of teeth and supporting structures
0.887 0.112 0.000
Z13 Special screening examination for other diseases and disorders
0.887 0.113 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.886 0.114 0.000
K70.3 Alcoholic cirrhosis of liver
0.878 0.122 0.000
M51 Other intervertebral disk disorders
0.877 0.123 0.000
F17.1 Harmful use
0.877 0.123 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.876 0.124 0.000
I08 Multiple valve diseases
0.873 0.127 0.000
S20-S29 Injuries to the thorax
0.873 0.127 0.000
K29.6 Other gastritis
0.872 0.128 0.000
G56 Mononeuropathies of upper limb
0.870 0.130 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.870 0.130 0.000
I44 Atrioventricular and left bundle-branch block
0.869 0.131 0.000
M50 Cervical disk disorders
0.869 0.131 0.000
I85 Oesophageal varices
0.869 0.131 0.000
Z03.1 Observation for suspected malignant neoplasm
0.868 0.132 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.866 0.134 0.000
E11.3 With ophthalmic complications
0.861 0.139 0.000
K22 Other diseases of oesophagus
0.861 0.139 0.000
K29.8 Duodenitis
0.860 0.140 0.000
K04.7 Periapical abscess without sinus
0.856 0.144 0.000
E11.2 With renal complications
0.855 0.145 0.000
N20-N23 Urolithiasis
0.854 0.146 0.000
K70.9 Alcoholic liver disease, unspecified
0.853 0.147 0.000
K75 Other inflammatory liver diseases
0.853 0.147 0.000
S00-S09 Injuries to the head
0.851 0.149 0.000
Z03.5 Observation for other suspected cardiovascular diseases
0.851 0.149 0.000
M25.5 Pain in joint
0.850 0.150 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.842 0.158 0.000
M23.3 Other meniscus derangements
0.839 0.161 0.000
M47.80 Other spondylosis (Multiple sites in spine)
0.837 0.163 0.000
I35 Nonrheumatic aortic valve disorders
0.837 0.163 0.000
K22.1 Ulcer of oesophagus
0.837 0.163 0.000
N20 Calculus of kidney and ureter
0.834 0.166 0.000
M80-M85 Disorders of bone density and structure
0.834 0.166 0.000
N17-N19 Renal failure
0.833 0.167 0.000
K04.8 Radicular cyst
0.831 0.169 0.000
E14 Unspecified diabetes mellitus
0.827 0.173 0.000
G47 Sleep disorders
0.826 0.174 0.000
N70-N77 Inflammatory diseases of female pelvic organs
0.826 0.174 0.000
H30-H36 Disorders of choroid and retina
0.825 0.175 0.000
S70-S79 Injuries to the hip and thigh
0.824 0.176 0.000
K72 Hepatic failure, not elsewhere classified
0.824 0.176 0.000
K65-K67 Diseases of peritoneum
0.823 0.177 0.000
H65-H75 Diseases of middle ear and mastoid
0.821 0.179 0.000
M54.3 Sciatica
0.817 0.183 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.815 0.185 0.000
E20-E35 Disorders of other endocrine glands
0.815 0.185 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.814 0.186 0.000
K25 Gastric ulcer
0.814 0.186 0.000
M25.56 Pain in joint (Lower leg)
0.812 0.188 0.000
M47.82 Other spondylosis (Cervical region)
0.809 0.191 0.000
K14.8 Other diseases of tongue
0.809 0.191 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.809 0.191 0.000
K80-K87 Disorders of gallbladder, biliary tract and pancreas
0.809 0.191 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.808 0.192 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.808 0.192 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.807 0.193 0.000
F10.9 Unspecified mental and behavioural disorder
0.806 0.194 0.000
G44 Other headache syndromes
0.803 0.197 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.802 0.198 0.000
Chapter X Diseases of the respiratory system
0.802 0.198 0.000
M05-M14 Inflammatory polyarthropathies
0.801 0.199 0.000
M20 Acquired deformities of fingers and toes
0.800 0.200 0.000
K76.0 Fatty (change of) liver, not elsewhere classified
0.799 0.201 0.000
E10 Insulin-dependent diabetes mellitus
0.798 0.202 0.000
K08.3 Retained dental root
0.797 0.203 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.797 0.203 0.000
F31 Bipolar affective disorder
0.796 0.204 0.000
G20-G26 Extrapyramidal and movement disorders
0.796 0.204 0.000
M54.2 Cervicalgia
0.795 0.205 0.000
Z03.3 Observation for suspected nervous system disorder
0.793 0.206 0.000
G50 Disorders of trigeminal nerve
0.792 0.208 0.000
M50.3 Other cervical disk degeneration
0.789 0.211 0.000
I45 Other conduction disorders
0.788 0.212 0.000
E40-E46 Malnutrition
0.787 0.213 0.000
G56.0 Carpal tunnel syndrome
0.787 0.213 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.787 0.213 0.000
I86 Varicose veins of other sites
0.787 0.213 0.000
S90-S99 Injuries to the ankle and foot
0.786 0.214 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.786 0.214 0.000
M31 Other necrotising vasculopathies
0.786 0.214 0.000
I11 Hypertensive heart disease
0.784 0.215 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.784 0.216 0.000
N20.0 Calculus of kidney
0.783 0.217 0.000
Chapter I Certain infectious and parasitic diseases
0.783 0.217 0.000
K12 Stomatitis and related lesions
0.781 0.219 0.000
K29.1 Other acute gastritis
0.780 0.220 0.000
I85.9 Oesophageal varices without bleeding
0.779 0.221 0.000
Z04 Examination and observation for other reasons
0.779 0.221 0.000
M48 Other spondylopathies
0.779 0.221 0.000
G51 Facial nerve disorders
0.778 0.221 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.778 0.222 0.000
T79-T79 Certain early complications of trauma
0.777 0.223 0.000
E50-E64 Other nutritional deficiencies
0.777 0.223 0.000
M54.9 Dorsalgia, unspecified
0.776 0.224 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.776 0.224 0.000
H04 Disorders of lachrymal system
0.775 0.225 0.000
Z09 Follow-up examination after treatment for conditions other than malignant neoplasms
0.775 0.225 0.000
M51.2 Other specified intervertebral disk displacement
0.773 0.227 0.000
K35-K38 Diseases of appendix
0.773 0.227 0.000
H72 Perforation of tympanic membrane
0.773 0.227 0.000
K55-K64 Other diseases of intestines
0.771 0.229 0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.771 0.229 0.000
E11.4 With neurological complications
0.771 0.229 0.000
I49 Other cardiac arrhythmias
0.771 0.229 0.000
T66-T78 Other and unspecified effects of external causes
0.770 0.230 0.000
M47.2 Other spondylosis with radiculopathy
0.769 0.231 0.000
M25.4 Effusion of joint
0.768 0.232 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.768 0.232 0.000
K74.3 Primary biliary cirrhosis
0.767 0.233 0.000
T39.1 4-Aminophenol derivatives
0.766 0.234 0.000
M86-M90 Other osteopathies
0.762 0.238 0.000
M91-M94 Chondropathies
0.761 0.239 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.760 0.240 0.000
I82 Other venous embolism and thrombosis
0.760 0.240 0.000
S40-S49 Injuries to the shoulder and upper arm
0.759 0.240 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.759 0.241 0.000
I08.0 Disorders of both mitral and aortic valves
0.759 0.241 0.000
K02 Dental caries
0.758 0.242 0.000
I44.6 Other and unspecified fascicular block
0.757 0.243 0.000
Z01 Other special examinations and investigations of persons without complaint or reported diagnosis
0.757 0.243 0.000
T84.1 Mechanical complication of internal fixation device of bones of limb
0.756 0.244 0.000
M23.8 Other internal derangements of knee
0.756 0.244 0.000
I51 Complications and ill-defined descriptions of heart disease
0.756 0.244 0.000
K74.0 Hepatic fibrosis
0.755 0.245 0.000
I61 Intracerebral haemorrhage
0.753 0.247 0.000
Z11 Special screening examination for infectious and parasitic diseases
0.750 0.250 0.000
M21 Other acquired deformities of limbs
0.750 0.250 0.000
Z13.0 Special screening examination for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.749 0.251 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.748 0.252 0.000
G47.3 Sleep apnoea
0.747 0.253 0.000
K29.3 Chronic superficial gastritis
0.747 0.253 0.000
G30-G32 Other degenerative diseases of the nervous system
0.746 0.254 0.000
Z09.0 Follow-up examination after surgery for other conditions
0.745 0.255 0.000
E11.5 With peripheral circulatory complications
0.744 0.256 0.000
Z08 Follow-up examination after treatment for malignant neoplasm
0.743 0.257 0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts
0.742 0.258 0.000
F32 Depressive episode
0.740 0.260 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.740 0.260 0.000
I85.0 Oesophageal varices with bleeding
0.737 0.263 0.000
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)
0.736 0.264 0.000
H52 Disorders of refraction and accommodation
0.732 0.268 0.000
K75.8 Other specified inflammatory liver diseases
0.731 0.268 0.000
I81 Portal vein thrombosis
0.731 0.269 0.000
K11 Diseases of salivary glands
0.731 0.269 0.000
N17 Acute renal failure
0.731 0.269 0.000
M22 Disorders of patella
0.730 0.270 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.730 0.270 0.000
I44.0 Atrioventricular block, first degree
0.729 0.271 0.000
I35.0 Aortic (valve) stenosis
0.729 0.271 0.000
Chapter XXII Codes for special purposes
0.729 0.271 0.000
Q60-Q64 Congenital malformations of the urinary system
0.729 0.271 0.000
M65-M68 Disorders of synovium and tendon
0.727 0.273 0.000
K76.9 Liver disease, unspecified
0.725 0.275 0.000
H35 Other retinal disorders
0.725 0.275 0.000
K08.9 Disorder of teeth and supporting structures, unspecified
0.724 0.275 0.000
N20.1 Calculus of ureter
0.722 0.278 0.000
Z00 General examination and investigation of persons without complaint or reported diagnosis
0.722 0.278 0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.722 0.278 0.000
I65.2 Occlusion and stenosis of carotid artery
0.722 0.278 0.000
I63 Cerebral infarction
0.722 0.278 0.000
N73 Other female pelvic inflammatory diseases
0.721 0.279 0.000
K29.0 Acute haemorrhagic gastritis
0.719 0.281 0.000
M54.6 Pain in thoracic spine
0.719 0.281 0.000
T81 Complications of procedures, not elsewhere classified
0.719 0.281 0.000
H55-H59 Other disorders of eye and adnexa
0.718 0.281 0.000
S50-S59 Injuries to the elbow and forearm
0.717 0.282 0.000
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)
0.718 0.282 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.717 0.283 0.000
Z13.6 Special screening examination for cardiovascular disorders
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
S10-S19 Injuries to the neck
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
S80-S89 Injuries to the knee and lower leg
0.717 0.283 0.000
K07 Dentofacial anomalies [including malocclusion]
0.717 0.283 0.000
K77 Liver disorders in diseases classified elsewhere
0.716 0.283 0.000
K73 Chronic hepatitis, not elsewhere classified
0.716 0.283 0.000
K71 Toxic liver disease
0.716 0.283 0.000
M54.1 Radiculopathy
0.716 0.284 0.000
M40-M43 Deforming dorsopathies
0.716 0.284 0.000
M46 Other inflammatory spondylopathies
0.715 0.284 0.000
H72.9 Perforation of tympanic membrane, unspecified
0.715 0.285 0.000
G43 Migraine
0.714 0.286 0.000
S27 Injury of other and unspecified intrathoracic organs
0.713 0.287 0.000
K83 Other diseases of biliary tract
0.713 0.287 0.000
G58 Other mononeuropathies
0.712 0.287 0.000
F99-F99 Unspecified mental disorder
0.712 0.288 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.712 0.288 0.000
F80-F89 Disorders of psychological development
0.712 0.288 0.000
F70-F79 Mental retardation
0.712 0.288 0.000
F60-F69 Disorders of adult personality and behaviour
0.712 0.288 0.000
I84 Haemorrhoids
0.712 0.288 0.000
M25.8 Other specified joint disorders
0.711 0.289 0.000
E13 Other specified diabetes mellitus
0.710 0.289 0.000
E12 Malnutrition-related diabetes mellitus
0.710 0.289 0.000
M53 Other dorsopathies, not elsewhere classified
0.709 0.291 0.000
M70-M79 Other soft tissue disorders
0.709 0.291 0.000
N00-N08 Glomerular diseases
0.709 0.291 0.000
K14.0 Glossitis
0.709 0.291 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.708 0.292 0.000
M80 Osteoporosis with pathological fracture
0.708 0.292 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.707 0.293 0.000
M34 Systemic sclerosis
0.707 0.293 0.000
M33 Dermatopolymyositis
0.707 0.293 0.000
M32 Systemic lupus erythematosus
0.707 0.293 0.000
M30 Polyarteritis nodosa and related conditions
0.707 0.293 0.000
G70-G73 Diseases of myoneural junction and muscle
0.707 0.293 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.707 0.293 0.000
K10 Other diseases of jaws
0.707 0.293 0.000
K09 Cysts of oral region, not elsewhere classified
0.707 0.293 0.000
K06 Other disorders of gingiva and edentulous alveolar ridge
0.707 0.293 0.000
K03 Other diseases of hard tissues of teeth
0.707 0.293 0.000
K00 Disorders of tooth development and eruption
0.707 0.293 0.000
E11.8 With unspecified complications
0.707 0.293 0.000
E11.7 With multiple complications
0.707 0.293 0.000
E11.6 With other specified complications
0.707 0.293 0.000
E11.1 With ketoacidosis
0.707 0.293 0.000
E11.0 With coma
0.707 0.293 0.000
H04.5 Stenosis and insufficiency of lachrymal passages
0.707 0.293 0.000
Z04.8 Examination and observation for other specified reasons
0.706 0.294 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.706 0.294 0.000
H10-H13 Disorders of conjunctiva
0.706 0.294 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.706 0.294 0.000
N99-N99 Other disorders of the genitourinary system
0.704 0.296 0.000
I44.7 Left bundle-branch block, unspecified
0.704 0.296 0.000
T87 Complications peculiar to reattachment and amputation
0.704 0.296 0.000
T86 Failure and rejection of transplanted organs and tissues
0.704 0.296 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.704 0.296 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.703 0.296 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.703 0.296 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.703 0.296 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.703 0.296 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.703 0.296 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.703 0.296 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.703 0.296 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.703 0.296 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.703 0.296 0.000
T36 Poisoning by systemic antibiotics
0.703 0.296 0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances
0.703 0.297 0.000
F18 Mental and behavioural disorders due to use of volatile solvents
0.703 0.297 0.000
F16 Mental and behavioural disorders due to use of hallucinogens
0.703 0.297 0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine
0.703 0.297 0.000
F14 Mental and behavioural disorders due to use of cocaine
0.703 0.297 0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics
0.703 0.297 0.000
F12 Mental and behavioural disorders due to use of cannabinoids
0.703 0.297 0.000
F11 Mental and behavioural disorders due to use of opioids
0.703 0.297 0.000
I15 Secondary hypertension
0.703 0.297 0.000
I13 Hypertensive heart and renal disease
0.703 0.297 0.000
K65 Peritonitis
0.702 0.297 0.000
Z13.1 Special screening examination for diabetes mellitus
0.702 0.298 0.000
I46 Cardiac arrest
0.700 0.300 0.000
G56.2 Lesion of ulnar nerve
0.699 0.301 0.000
K72.9 Hepatic failure, unspecified
0.698 0.302 0.000
Z10 Routine general health check-up of defined subpopulation
0.696 0.304 0.000
E14.9 Without complications
0.696 0.304 0.000
M54.39 Sciatica (Site unspecified)
0.696 0.304 0.000
E65-E68 Obesity and other hyperalimentation
0.694 0.306 0.000
I33 Acute and subacute endocarditis
0.694 0.306 0.000
K76.7 Hepatorenal syndrome
0.694 0.306 0.000
K76.5 Hepatic veno-occlusive disease
0.694 0.306 0.000
K76.4 Peliosis hepatis
0.694 0.306 0.000
K76.3 Infarction of liver
0.694 0.306 0.000
K76.2 Central haemorrhagic necrosis of liver
0.694 0.306 0.000
K76.1 Chronic passive congestion of liver
0.694 0.306 0.000
M49 Spondylopathies in diseases classified elsewhere
0.693 0.306 0.000
M45 Ankylosing spondylitis
0.693 0.306 0.000
M23.5 Chronic instability of knee
0.691 0.309 0.000
Z03.6 Observation for suspected toxic effect from ingested substance
0.691 0.309 0.000
Z03.2 Observation for suspected mental and behavioural disorders
0.691 0.309 0.000
Z03.0 Observation for suspected tuberculosis
0.691 0.309 0.000
S02 Fracture of skull and facial bones
0.691 0.309 0.000
M54.22 Cervicalgia (Cervical region)
0.690 0.310 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.690 0.310 0.000
K50-K52 Noninfective enteritis and colitis
0.690 0.310 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.690 0.310 0.000
M23.4 Loose body in knee
0.690 0.310 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.689 0.311 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.689 0.311 0.000
M06 Other rheumatoid arthritis
0.689 0.311 0.000
S09 Other and unspecified injuries of head
0.689 0.311 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.688 0.312 0.000
N20.2 Calculus of kidney with calculus of ureter
0.688 0.312 0.000
M25.55 Pain in joint (Pelvic region and thigh)
0.688 0.312 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.688 0.312 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.687 0.313 0.000
M24 Other specific joint derangements
0.687 0.313 0.000
T43.2 Other and unspecified antidepressants
0.687 0.313 0.000
K70.4 Alcoholic hepatic failure
0.686 0.314 0.000
K70.2 Alcoholic fibrosis and sclerosis of liver
0.686 0.314 0.000
K70.1 Alcoholic hepatitis
0.686 0.314 0.000
K70.0 Alcoholic fatty liver
0.686 0.314 0.000
M47.89 Other spondylosis (Site unspecified)
0.685 0.315 0.000
H60-H62 Diseases of external ear
0.685 0.315 0.000
J00-J06 Acute upper respiratory infections
0.684 0.315 0.000
M54.4 Lumbago with sciatica
0.683 0.317 0.000
H34 Retinal vascular occlusions
0.683 0.317 0.000
G54 Nerve root and plexus disorders
0.682 0.318 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.682 0.318 0.000
G52 Disorders of other cranial nerves
0.682 0.318 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.682 0.318 0.000
I42 Cardiomyopathy
0.681 0.319 0.000
I86.4 Gastric varices
0.681 0.319 0.000
S60-S69 Injuries to the wrist and hand
0.680 0.320 0.000
I07 Rheumatic tricuspid valve diseases
0.679 0.320 0.000
M20.5 Other deformities of toe(s) (acquired)
0.679 0.321 0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]
0.679 0.321 0.000
T39.0 Salicylates
0.679 0.321 0.000
G50.0 Trigeminal neuralgia
0.678 0.322 0.000
K60 Fissure and fistula of anal and rectal regions
0.678 0.322 0.000
M20.2 Hallux rigidus
0.677 0.323 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.677 0.323 0.000
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified
0.677 0.323 0.000
M20.3 Other deformity of hallux (acquired)
0.676 0.324 0.000
I52 Other heart disorders in diseases classified elsewhere
0.676 0.324 0.000
I48 Atrial fibrillation and flutter
0.676 0.324 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.676 0.324 0.000
I41 Myocarditis in diseases classified elsewhere
0.676 0.324 0.000
I40 Acute myocarditis
0.676 0.324 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.676 0.324 0.000
I37 Pulmonary valve disorders
0.676 0.324 0.000
I36 Nonrheumatic tricuspid valve disorders
0.676 0.324 0.000
I32 Pericarditis in diseases classified elsewhere
0.676 0.324 0.000
I30 Acute pericarditis
0.676 0.324 0.000
M54.8 Other dorsalgia
0.675 0.325 0.000
M54.0 Panniculitis affecting regions of neck and back
0.675 0.325 0.000
F10.8 Other mental and behavioural disorders
0.675 0.325 0.000
F10.7 Residual and late-onset psychotic disorder
0.675 0.325 0.000
F10.6 Amnesic syndrome
0.675 0.325 0.000
F10.5 Psychotic disorder
0.675 0.325 0.000
F10.4 Withdrawal state with delirium
0.675 0.325 0.000
S72 Fracture of femur
0.675 0.325 0.000
E10.9 Without complications
0.675 0.325 0.000
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)
0.674 0.326 0.000
K25.7 Chronic without haemorrhage or perforation
0.672 0.328 0.000
G44.2 Tension-type headache
0.672 0.328 0.000
K04.9 Other and unspecified diseases of pulp and periapical tissues
0.671 0.329 0.000
K04.6 Periapical abscess with sinus
0.671 0.329 0.000
K04.4 Acute apical periodontitis of pulpal origin
0.671 0.329 0.000
K04.3 Abnormal hard tissue formation in pulp
0.671 0.329 0.000
K04.2 Pulp degeneration
0.671 0.329 0.000
K04.1 Necrosis of pulp
0.671 0.329 0.000
K04.0 Pulpitis
0.671 0.329 0.000
I88 Nonspecific lymphadenitis
0.670 0.330 0.000
I87 Other disorders of veins
0.670 0.330 0.000
M51.8 Other specified intervertebral disk disorders
0.670 0.330 0.000
K55 Vascular disorders of intestine
0.670 0.330 0.000
I08.1 Disorders of both mitral and tricuspid valves
0.670 0.330 0.000
H02 Other disorders of eyelid
0.669 0.331 0.000
Z13.9 Special screening examination, unspecified
0.669 0.331 0.000
S05 Injury of eye and orbit
0.669 0.331 0.000
K28 Gastrojejunal ulcer
0.669 0.331 0.000
K23 Disorders of oesophagus in diseases classified elsewhere
0.669 0.331 0.000
J60-J70 Lung diseases due to external agents
0.668 0.332 0.000
F31.0 Bipolar affective disorder, current episode hypomanic
0.668 0.332 0.000
G44.0 Cluster headache syndrome
0.668 0.332 0.000
J90-J94 Other diseases of pleura
0.667 0.333 0.000
M47.1 Other spondylosis with myelopathy
0.667 0.333 0.000
M47.0 Anterior spinal and vertebral artery compression syndromes
0.667 0.333 0.000
N18 Chronic renal failure
0.667 0.333 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.667 0.333 0.000
K31 Other diseases of stomach and duodenum
0.666 0.334 0.000
S20 Superficial injury of thorax
0.665 0.335 0.000
I09 Other rheumatic heart diseases
0.665 0.335 0.000
I06 Rheumatic aortic valve diseases
0.665 0.335 0.000
I05 Rheumatic mitral valve diseases
0.665 0.335 0.000
G47.1 Disorders of excessive somnolence [hypersomnias]
0.665 0.335 0.000
T82.1 Mechanical complication of cardiac electronic device
0.665 0.335 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.664 0.336 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.663 0.337 0.000
I74 Arterial embolism and thrombosis
0.663 0.337 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.663 0.337 0.000
N76 Other inflammation of vagina and vulva
0.663 0.337 0.000
K05 Gingivitis and periodontal diseases
0.662 0.337 0.000
M31.3 Wegener's granulomatosis
0.662 0.338 0.000
K29.9 Gastroduodenitis, unspecified
0.661 0.339 0.000
K29.2 Alcoholic gastritis
0.661 0.339 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.661 0.339 0.000
M50.0 Cervical disk disorder with myelopathy
0.661 0.339 0.000
M25.9 Joint disorder, unspecified
0.660 0.339 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.660 0.339 0.000
M25.3 Other instability of joint
0.660 0.339 0.000
M25.2 Flail joint
0.660 0.339 0.000
M25.1 Fistula of joint
0.660 0.339 0.000
M25.0 Haemarthrosis
0.660 0.339 0.000
I51.7 Cardiomegaly
0.660 0.340 0.000
F17.9 Unspecified mental and behavioural disorder
0.660 0.340 0.000
F17.8 Other mental and behavioural disorders
0.660 0.340 0.000
F17.7 Residual and late-onset psychotic disorder
0.660 0.340 0.000
F17.6 Amnesic syndrome
0.660 0.340 0.000
F17.5 Psychotic disorder
0.660 0.340 0.000
F17.4 Withdrawal state with delirium
0.660 0.340 0.000
F17.3 Withdrawal state
0.660 0.340 0.000
F17.0 Acute intoxication
0.660 0.340 0.000
G90-G99 Other disorders of the nervous system
0.659 0.341 0.000
K76.8 Other specified diseases of liver
0.659 0.341 0.000
K74.6 Other and unspecified cirrhosis of liver
0.659 0.341 0.000
M54.99 Dorsalgia, unspecified (Site unspecified)
0.658 0.342 0.000
M25.46 Effusion of joint (Lower leg)
0.658 0.342 0.000
N17.9 Acute renal failure, unspecified
0.658 0.342 0.000
F17.2 Dependence syndrome
0.657 0.343 0.000
M23.9 Internal derangement of knee, unspecified
0.657 0.343 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.657 0.343 0.000
M23.1 Discoid meniscus (congenital)
0.657 0.343 0.000
M23.0 Cystic meniscus
0.657 0.343 0.000
K80 Cholelithiasis
0.657 0.343 0.000
N19 Unspecified renal failure
0.656 0.344 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.655 0.345 0.000
G51.0 Bell's palsy
0.655 0.345 0.000
I49.3 Ventricular premature depolarisation
0.654 0.346 0.000
N10-N16 Renal tubulo-interstitial diseases
0.654 0.346 0.000
Q50-Q56 Congenital malformations of genital organs
0.653 0.346 0.000
M47.9 Spondylosis, unspecified
0.653 0.347 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.653 0.347 0.000
G41 Status epilepticus
0.653 0.347 0.000
Z03.9 Observation for suspected disease or condition, unspecified
0.653 0.347 0.000
I84.9 Unspecified haemorrhoids without complication
0.652 0.348 0.000
K12.0 Recurrent oral aphthae
0.651 0.349 0.000
M51.0 Lumbar and other intervertebral disk disorders with myelopathy
0.650 0.350 0.000
K60.1 Chronic anal fissure
0.650 0.350 0.000
E23 Hypofunction and other disorders of pituitary gland
0.648 0.352 0.000
T40.2 Other opioids
0.648 0.352 0.000
M23.30 Other meniscus derangements (Multiple sites)
0.648 0.352 0.000
B15-B19 Viral hepatitis
0.647 0.353 0.000
M54.36 Sciatica (Lumbar region)
0.647 0.353 0.000
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms
0.646 0.354 0.000
I61.9 Intracerebral haemorrhage, unspecified
0.646 0.354 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.646 0.354 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.646 0.354 0.000
I45.1 Other and unspecified right bundle-branch block
0.646 0.354 0.000
K74.5 Biliary cirrhosis, unspecified
0.645 0.355 0.000
K74.4 Secondary biliary cirrhosis
0.645 0.355 0.000
K74.2 Hepatic fibrosis with hepatic sclerosis
0.645 0.355 0.000
K74.1 Hepatic sclerosis
0.645 0.355 0.000
I11.9 Hypertensive heart disease without (congestive) heart failure
0.644 0.356 0.000
K22.9 Disease of oesophagus, unspecified
0.644 0.356 0.000
I31 Other diseases of pericardium
0.643 0.357 0.000
K75.0 Abscess of liver
0.643 0.357 0.000
H72.0 Central perforation of tympanic membrane
0.643 0.357 0.000
K14.6 Glossodynia
0.642 0.357 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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