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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2358994
log Bayes Factor = 56.0385
Chromosome 1   position 114,429,461  (GRCh37) Explore rs2358994 on Ensembl!
Variant rs2358994 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
E10.9 Without complications
1.000 0.000 0.000
M06.9 Rheumatoid arthritis, unspecified
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
1.000 0.000 0.000
M06 Other rheumatoid arthritis
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
M05-M14 Inflammatory polyarthropathies
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
1.000 0.000 0.000
E03 Other hypothyroidism
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
E10.1 With ketoacidosis
1.000 0.000 0.000
E11 Non-insulin-dependent diabetes mellitus
0.998 0.002 0.000
I25 Chronic ischaemic heart disease
0.996 0.004 0.000
I20-I25 Ischaemic heart diseases
0.996 0.004 0.000
Chapter X Diseases of the respiratory system
0.995 0.005 0.000
I25.2 Old myocardial infarction
0.995 0.005 0.000
Chapter IX Diseases of the circulatory system
0.994 0.006 0.000
M75 Shoulder lesions
0.991 0.009 0.000
M75.0 Adhesive capsulitis of shoulder
0.991 0.009 0.000
M70-M79 Other soft tissue disorders
0.991 0.009 0.000
I25.1 Atherosclerotic heart disease
0.990 0.010 0.000
E11.9 Without complications
0.987 0.013 0.000
E70-E90 Metabolic disorders
0.986 0.014 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.983 0.017 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.980 0.020 0.000
E10.5 With peripheral circulatory complications
0.979 0.021 0.000
E10.3 With ophthalmic complications
0.977 0.023 0.000
D50-D53 Nutritional anaemias
0.973 0.027 0.000
E89.0 Postprocedural hypothyroidism
0.973 0.027 0.000
D51 Vitamin B12 deficiency anaemia
0.971 0.029 0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.969 0.031 0.000
M86-M90 Other osteopathies
0.969 0.031 0.000
E65-E68 Obesity and other hyperalimentation
0.967 0.033 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.959 0.041 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.959 0.041 0.000
I21 Acute myocardial infarction
0.957 0.043 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.956 0.044 0.000
M06.3 Rheumatoid nodule
0.955 0.045 0.000
M75.2 Bicipital tendinitis
0.954 0.046 0.000
E20-E35 Disorders of other endocrine glands
0.952 0.048 0.000
E78.0 Pure hypercholesterolaemia
0.945 0.055 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.945 0.055 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.944 0.056 0.000
E66 Obesity
0.943 0.057 0.000
J20-J22 Other acute lower respiratory infections
0.935 0.065 0.000
E11.5 With peripheral circulatory complications
0.933 0.067 0.000
M86 Osteomyelitis
0.932 0.068 0.000
E16 Other disorders of pancreatic internal secretion
0.930 0.070 0.000
J90-J94 Other diseases of pleura
0.930 0.070 0.000
D80-D89 Certain disorders involving the immune mechanism
0.927 0.073 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.923 0.077 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.921 0.079 0.000
I21.9 Acute myocardial infarction, unspecified
0.920 0.080 0.000
E66.9 Obesity, unspecified
0.919 0.081 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.918 0.082 0.000
E11.1 With ketoacidosis
0.917 0.083 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.915 0.085 0.000
M75.5 Bursitis of shoulder
0.911 0.089 0.000
M05 Seropositive rheumatoid arthritis
0.911 0.089 0.000
M07 Psoriatic and enteropathic arthropathies
0.909 0.091 0.000
J86 Pyothorax
0.908 0.092 0.000
J92 Pleural plaque
0.907 0.093 0.000
M60-M63 Disorders of muscles
0.906 0.094 0.000
E16.2 Hypoglycaemia, unspecified
0.905 0.095 0.000
I20 Angina pectoris
0.904 0.096 0.000
E27 Other disorders of adrenal gland
0.904 0.096 0.000
J09-J18 Influenza and pneumonia
0.894 0.106 0.000
M06.34 Rheumatoid nodule (Hand)
0.893 0.107 0.000
I80 Phlebitis and thrombophlebitis
0.888 0.112 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.885 0.115 0.000
J92.9 Pleural plaque without asbestos
0.883 0.117 0.000
M86.9 Osteomyelitis, unspecified
0.883 0.117 0.000
Chapter VI Diseases of the nervous system
0.880 0.120 0.000
J86.9 Pyothorax without fistula
0.878 0.122 0.000
S00-S09 Injuries to the head
0.878 0.122 0.000
S02 Fracture of skull and facial bones
0.875 0.125 0.000
E03.8 Other specified hypothyroidism
0.874 0.126 0.000
I20.9 Angina pectoris, unspecified
0.873 0.127 0.000
J22 Unspecified acute lower respiratory infection
0.871 0.129 0.000
E78.8 Other disorders of lipoprotein metabolism
0.869 0.131 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.868 0.132 0.000
E89.3 Postprocedural hypopituitarism
0.861 0.139 0.000
E10.6 With other specified complications
0.860 0.140 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.857 0.143 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.855 0.145 0.000
G70-G73 Diseases of myoneural junction and muscle
0.851 0.149 0.000
M12 Other specific arthropathies
0.851 0.149 0.000
S02.2 Fracture of nasal bones
0.850 0.150 0.000
Q25 Congenital malformations of great arteries
0.849 0.151 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.847 0.153 0.000
M07.3 Other psoriatic arthropathies
0.843 0.157 0.000
S06 Intracranial injury
0.842 0.158 0.000
D84 Other immunodeficiencies
0.837 0.163 0.000
E10.0 With coma
0.835 0.165 0.000
E66.8 Other obesity
0.835 0.165 0.000
E10.8 With unspecified complications
0.833 0.167 0.000
S02.20 Fracture of nasal bones (closed)
0.832 0.168 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.829 0.171 0.000
M06.8 Other specified rheumatoid arthritis
0.825 0.175 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.823 0.177 0.000
I25.5 Ischaemic cardiomyopathy
0.823 0.177 0.000
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities
0.820 0.180 0.000
I80.3 Phlebitis and thrombophlebitis of lower extremities, unspecified
0.817 0.183 0.000
J60-J70 Lung diseases due to external agents
0.817 0.183 0.000
I87 Other disorders of veins
0.816 0.184 0.000
G51 Facial nerve disorders
0.814 0.186 0.000
M06.0 Seronegative rheumatoid arthritis
0.814 0.186 0.000
E10.2 With renal complications
0.813 0.186 0.000
J94 Other pleural conditions
0.813 0.187 0.000
G50 Disorders of trigeminal nerve
0.812 0.188 0.000
E11.0 With coma
0.812 0.188 0.000
I83 Varicose veins of lower extremities
0.811 0.189 0.000
E27.1 Primary adrenocortical insufficiency
0.808 0.192 0.000
M60 Myositis
0.808 0.192 0.000
E05.9 Thyrotoxicosis, unspecified
0.806 0.194 0.000
Chapter V Mental and behavioural disorders
0.805 0.195 0.000
J13 Pneumonia due to Streptococcus pneumoniae
0.804 0.196 0.000
Q21 Congenital malformations of cardiac septa
0.799 0.201 0.000
E10.4 With neurological complications
0.798 0.202 0.000
M07.39 Other psoriatic arthropathies (Site unspecified)
0.796 0.204 0.000
D86 Sarcoidosis
0.795 0.205 0.000
J95-J99 Other diseases of the respiratory system
0.795 0.205 0.000
S06.2 Diffuse brain injury
0.792 0.208 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.792 0.208 0.000
E27.9 Disorder of adrenal gland, unspecified
0.792 0.208 0.000
J17 Pneumonia in diseases classified elsewhere
0.790 0.210 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.788 0.212 0.000
G70 Myasthenia gravis and other myoneural disorders
0.786 0.214 0.000
E85 Amyloidosis
0.784 0.216 0.000
G50.0 Trigeminal neuralgia
0.784 0.216 0.000
M86.97 Osteomyelitis, unspecified (Ankle and foot)
0.782 0.218 0.000
E24 Cushing's syndrome
0.782 0.218 0.000
M71 Other bursopathies
0.782 0.218 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.779 0.221 0.000
E40-E46 Malnutrition
0.779 0.221 0.000
Q24 Other congenital malformations of heart
0.778 0.222 0.000
M90 Osteopathies in diseases classified elsewhere
0.778 0.222 0.000
M76 Enthesopathies of lower limb, excluding foot
0.777 0.223 0.000
I10-I15 Hypertensive diseases
0.772 0.228 0.000
M86.8 Other osteomyelitis
0.771 0.228 0.000
S00 Superficial injury of head
0.771 0.229 0.000
M06.33 Rheumatoid nodule (Forearm)
0.770 0.230 0.000
S20-S29 Injuries to the thorax
0.769 0.231 0.000
M88 Paget's disease of bone [osteitis deformans]
0.769 0.231 0.000
E23 Hypofunction and other disorders of pituitary gland
0.767 0.233 0.000
E06 Thyroiditis
0.766 0.234 0.000
E31 Polyglandular dysfunction
0.765 0.235 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.763 0.237 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.763 0.237 0.000
D84.9 Immunodeficiency, unspecified
0.761 0.239 0.000
D55-D59 Haemolytic anaemias
0.760 0.240 0.000
T66-T78 Other and unspecified effects of external causes
0.760 0.240 0.000
F20 Schizophrenia
0.760 0.240 0.000
S06.20 Diffuse brain injury (without open intracranial wound)
0.757 0.243 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.756 0.243 0.000
E88 Other metabolic disorders
0.756 0.244 0.000
S10-S19 Injuries to the neck
0.756 0.244 0.000
I20.8 Other forms of angina pectoris
0.756 0.244 0.000
S00.0 Superficial injury of scalp
0.754 0.246 0.000
E27.2 Addisonian crisis
0.753 0.247 0.000
M06.30 Rheumatoid nodule (Multiple sites)
0.753 0.247 0.000
E26 Hyperaldosteronism
0.753 0.247 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.751 0.249 0.000
E05.8 Other thyrotoxicosis
0.748 0.252 0.000
E20 Hypoparathyroidism
0.747 0.253 0.000
I83.1 Varicose veins of lower extremities with inflammation
0.747 0.253 0.000
I82 Other venous embolism and thrombosis
0.746 0.254 0.000
E84 Cystic fibrosis
0.745 0.255 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.742 0.258 0.000
E16.1 Other hypoglycaemia
0.740 0.260 0.000
M86.99 Osteomyelitis, unspecified (Site unspecified)
0.740 0.260 0.000
J21 Acute bronchiolitis
0.739 0.261 0.000
M60.9 Myositis, unspecified
0.739 0.261 0.000
F20.9 Schizophrenia, unspecified
0.738 0.262 0.000
M86.95 Osteomyelitis, unspecified (Pelvic region and thigh)
0.736 0.264 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.733 0.267 0.000
S02.0 Fracture of vault of skull
0.733 0.267 0.000
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.732 0.268 0.000
J92.0 Pleural plaque with presence of asbestos
0.731 0.269 0.000
G71 Primary disorders of muscles
0.731 0.269 0.000
M62 Other disorders of muscle
0.731 0.269 0.000
G70.0 Myasthenia gravis
0.729 0.270 0.000
G51.0 Bell's palsy
0.729 0.271 0.000
E28 Ovarian dysfunction
0.727 0.273 0.000
D83 Common variable immunodeficiency
0.726 0.274 0.000
Q00-Q07 Congenital malformations of the nervous system
0.726 0.274 0.000
J17.2 Pneumonia in mycoses
0.725 0.275 0.000
G58 Other mononeuropathies
0.724 0.276 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.724 0.276 0.000
S02.5 Fracture of tooth
0.724 0.276 0.000
J99 Respiratory disorders in diseases classified elsewhere
0.723 0.277 0.000
I87.1 Compression of vein
0.722 0.278 0.000
M05.8 Other seropositive rheumatoid arthritis
0.722 0.278 0.000
J10 Influenza due to identified influenza virus
0.721 0.279 0.000
Q25.1 Coarctation of aorta
0.719 0.281 0.000
E10.7 With multiple complications
0.717 0.283 0.000
M06.2 Rheumatoid bursitis
0.717 0.283 0.000
M06.1 Adult-onset Still's disease
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.717 0.283 0.000
M08 Juvenile arthritis
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
E03.5 Myxoedema coma
0.717 0.283 0.000
E03.4 Atrophy of thyroid (acquired)
0.717 0.283 0.000
E03.3 Postinfectious hypothyroidism
0.717 0.283 0.000
E03.1 Congenital hypothyroidism without goitre
0.717 0.283 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.717 0.283 0.000
E11.7 With multiple complications
0.715 0.284 0.000
E78.4 Other hyperlipidaemia
0.715 0.285 0.000
I25.6 Silent myocardial ischaemia
0.714 0.286 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.714 0.286 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.713 0.287 0.000
M80-M85 Disorders of bone density and structure
0.712 0.287 0.001
I00-I02 Acute rheumatic fever
0.713 0.287 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.711 0.289 0.000
M75.8 Other shoulder lesions
0.711 0.289 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.710 0.289 0.000
E78.1 Pure hyperglyceridaemia
0.710 0.290 0.000
M12.2 Villonodular synovitis (pigmented)
0.709 0.291 0.000
E65 Localised adiposity
0.708 0.292 0.000
S06.6 Traumatic subarachnoid haemorrhage
0.707 0.293 0.000
Q25.4 Other congenital malformations of aorta
0.707 0.293 0.000
E79 Disorders of purine and pyrimidine metabolism
0.707 0.293 0.000
E77 Disorders of glycoprotein metabolism
0.707 0.293 0.000
E76 Disorders of glycosaminoglycan metabolism
0.707 0.293 0.000
E72 Other disorders of amino-acid metabolism
0.707 0.293 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.707 0.293 0.000
E70 Disorders of aromatic amino-acid metabolism
0.707 0.293 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.707 0.293 0.000
M13 Other arthritis
0.707 0.293 0.000
S02.4 Fracture of malar and maxillary bones
0.704 0.296 0.000
Q70 Syndactyly
0.703 0.296 0.000
J61 Pneumoconiosis due to asbestos and other mineral fibres
0.703 0.297 0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.703 0.297 0.000
E89.8 Other postprocedural endocrine and metabolic disorders
0.703 0.297 0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.703 0.297 0.000
E89.5 Postprocedural testicular hypofunction
0.703 0.297 0.000
E89.4 Postprocedural ovarian failure
0.703 0.297 0.000
E89.1 Postprocedural hypoinsulinaemia
0.703 0.297 0.000
S02.7 Multiple fractures involving skull and facial bones
0.701 0.299 0.000
T78 Adverse effects, not elsewhere classified
0.701 0.299 0.000
G20-G26 Extrapyramidal and movement disorders
0.700 0.300 0.000
J30-J39 Other diseases of upper respiratory tract
0.700 0.300 0.000
I88 Nonspecific lymphadenitis
0.699 0.300 0.000
G72 Other myopathies
0.699 0.301 0.000
I15 Secondary hypertension
0.699 0.301 0.000
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.699 0.301 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.699 0.301 0.000
J12 Viral pneumonia, not elsewhere classified
0.698 0.302 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.697 0.303 0.000
M86.6 Other chronic osteomyelitis
0.697 0.303 0.000
Q22 Congenital malformations of pulmonary and tricuspid valves
0.696 0.303 0.000
D51.8 Other vitamin B12 deficiency anaemias
0.696 0.304 0.000
D51.3 Other dietary vitamin B12 deficiency anaemia
0.696 0.304 0.000
D51.2 Transcobalamin II deficiency
0.696 0.304 0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.696 0.304 0.000
M06.37 Rheumatoid nodule (Ankle and foot)
0.695 0.305 0.000
M87 Osteonecrosis
0.695 0.305 0.000
Q65 Congenital deformities of hip
0.694 0.306 0.000
E67 Other hyperalimentation
0.693 0.306 0.000
E68 Sequelae of hyperalimentation
0.693 0.306 0.000
M00-M03 Infectious arthropathies
0.693 0.307 0.000
S09 Other and unspecified injuries of head
0.693 0.307 0.000
J20 Acute bronchitis
0.692 0.308 0.000
M71.2 Synovial cyst of popliteal space [Baker]
0.691 0.309 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.691 0.309 0.000
J86.0 Pyothorax with fistula
0.690 0.310 0.000
E74 Other disorders of carbohydrate metabolism
0.689 0.311 0.000
M60.99 Myositis, unspecified (Site unspecified)
0.689 0.311 0.000
E15 Nondiabetic hypoglycaemic coma
0.688 0.312 0.000
I23 Certain current complications following acute myocardial infarction
0.688 0.312 0.000
Q35-Q37 Cleft lip and cleft palate
0.688 0.312 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.688 0.312 0.000
D53 Other nutritional anaemias
0.687 0.313 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.687 0.313 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.687 0.313 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.686 0.314 0.000
J16 Pneumonia due to other infectious organisms, not elsewhere classified
0.686 0.314 0.000
E78.3 Hyperchylomicronaemia
0.685 0.315 0.000
M06.39 Rheumatoid nodule (Site unspecified)
0.685 0.315 0.000
M06.38 Rheumatoid nodule (Other)
0.685 0.315 0.000
M06.36 Rheumatoid nodule (Lower leg)
0.685 0.315 0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.685 0.315 0.000
M06.31 Rheumatoid nodule (Shoulder region)
0.685 0.315 0.000
E85.4 Organ-limited amyloidosis
0.685 0.315 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.684 0.316 0.000
J94.1 Fibrothorax
0.684 0.316 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.683 0.317 0.000
E32 Diseases of thymus
0.683 0.317 0.000
E30 Disorders of puberty, not elsewhere classified
0.683 0.317 0.000
E25 Adrenogenital disorders
0.683 0.317 0.000
E86 Volume depletion
0.682 0.318 0.000
Q25.6 Stenosis of pulmonary artery
0.681 0.319 0.000
E11.4 With neurological complications
0.681 0.319 0.000
S05 Injury of eye and orbit
0.680 0.320 0.000
M86.98 Osteomyelitis, unspecified (Other)
0.678 0.322 0.000
E13 Other specified diabetes mellitus
0.678 0.322 0.000
E23.0 Hypopituitarism
0.678 0.322 0.000
I81 Portal vein thrombosis
0.678 0.322 0.000
Q27 Other congenital malformations of peripheral vascular system
0.677 0.322 0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.677 0.323 0.000
E66.1 Drug-induced obesity
0.676 0.324 0.000
M06.32 Rheumatoid nodule (Upper arm)
0.675 0.325 0.000
I80.9 Phlebitis and thrombophlebitis of unspecified site
0.674 0.326 0.000
I80.1 Phlebitis and thrombophlebitis of femoral vein
0.673 0.327 0.000
S00.8 Superficial injury of other parts of head
0.672 0.328 0.000
T24 Burn and corrosion of hip and lower limb, except ankle and foot
0.672 0.328 0.000
J99.8 Respiratory disorders in other diseases classified elsewhere
0.671 0.329 0.000
M07.38 Other psoriatic arthropathies (Other)
0.671 0.329 0.000
S02.1 Fracture of base of skull
0.670 0.330 0.000
Q66 Congenital deformities of feet
0.670 0.330 0.000
M12.3 Palindromic rheumatism
0.670 0.330 0.000
M75.9 Shoulder lesion, unspecified
0.669 0.331 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.669 0.331 0.000
M86.5 Other chronic haematogenous osteomyelitis
0.668 0.332 0.000
M86.4 Chronic osteomyelitis with draining sinus
0.668 0.332 0.000
M86.3 Chronic multifocal osteomyelitis
0.668 0.332 0.000
M86.2 Subacute osteomyelitis
0.668 0.332 0.000
M86.1 Other acute osteomyelitis
0.668 0.332 0.000
M86.0 Acute haematogenous osteomyelitis
0.668 0.332 0.000
T00-T07 Injuries involving multiple body regions
0.667 0.333 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.667 0.333 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.667 0.333 0.000
E16.4 Abnormal secretion of gastrin
0.667 0.333 0.000
E16.3 Increased secretion of glucagon
0.667 0.333 0.000
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified
0.667 0.333 0.000
J85 Abscess of lung and mediastinum
0.666 0.333 0.000
D86.3 Sarcoidosis of skin
0.666 0.333 0.000
J33 Nasal polyp
0.665 0.335 0.000
E11.3 With ophthalmic complications
0.665 0.335 0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.665 0.335 0.000
D82 Immunodeficiency associated with other major defects
0.664 0.336 0.000
D81 Combined immunodeficiencies
0.664 0.336 0.000
D52 Folate deficiency anaemia
0.664 0.336 0.000
I25.4 Coronary artery aneurysm
0.662 0.338 0.000
Q26 Congenital malformations of great veins
0.662 0.338 0.000
Q20 Congenital malformations of cardiac chambers and connexions
0.662 0.338 0.000
M85 Other disorders of bone density and structure
0.661 0.338 0.001
M76.6 Achilles tendinitis
0.662 0.338 0.000
S02.3 Fracture of orbital floor
0.661 0.339 0.000
E78.6 Lipoprotein deficiency
0.661 0.339 0.000
G51.9 Disorder of facial nerve, unspecified
0.661 0.339 0.000
J94.2 Haemothorax
0.661 0.339 0.000
E06.3 Autoimmune thyroiditis
0.660 0.340 0.000
Q21.9 Congenital malformation of cardiac septum, unspecified
0.657 0.343 0.000
I25.3 Aneurysm of heart
0.657 0.343 0.000
M86.87 Other osteomyelitis (Ankle and foot)
0.657 0.343 0.000
F25 Schizoaffective disorders
0.656 0.343 0.000
E05.5 Thyroid crisis or storm
0.656 0.344 0.000
E05.4 Thyrotoxicosis factitia
0.656 0.344 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.656 0.344 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.656 0.344 0.000
T78.3 Angioneurotic oedema
0.655 0.345 0.000
T22 Burn and corrosion of shoulder and upper limb, except wrist and hand
0.655 0.345 0.000
Q77 Osteochondrodysplasia with defects of growth of tubular bones and spine
0.653 0.347 0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.653 0.347 0.000
M05.2 Rheumatoid vasculitis
0.653 0.347 0.000
M05.1 Rheumatoid lung disease
0.653 0.347 0.000
M05.0 Felty's syndrome
0.653 0.347 0.000
G51.8 Other disorders of facial nerve
0.653 0.347 0.000
M90.7 Fracture of bone in neoplastic disease
0.653 0.347 0.000
M07.6 Other enteropathic arthropathies
0.651 0.348 0.000
M07.5 Arthropathy in ulcerative colitis
0.651 0.348 0.000
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.651 0.348 0.000
M07.2 Psoriatic spondylitis
0.651 0.348 0.000
M07.1 Arthritis mutilans
0.651 0.348 0.000
M07.0 Distal interphalangeal psoriatic arthropathy
0.651 0.348 0.000
S02.9 Fracture of skull and facial bones, part unspecified
0.651 0.349 0.000
M85.6 Other cyst of bone
0.650 0.350 0.000
G20 Parkinson's disease
0.650 0.350 0.000
M63 Disorders of muscle in diseases classified elsewhere
0.650 0.350 0.000
M61 Calcification and ossification of muscle
0.650 0.350 0.000
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.649 0.351 0.000
E27.5 Adrenomedullary hyperfunction
0.648 0.352 0.000
E27.0 Other adrenocortical overactivity
0.648 0.352 0.000
M89 Other disorders of bone
0.648 0.352 0.000
S06.5 Traumatic subdural haemorrhage
0.647 0.352 0.000
E11.2 With renal complications
0.647 0.352 0.000
G51.3 Clonic hemifacial spasm
0.647 0.353 0.000
F30-F39 Mood [affective] disorders
0.644 0.356 0.000
I87.9 Disorder of vein, unspecified
0.644 0.356 0.000
J09 Influenza due to certain identified influenza virus
0.641 0.359 0.000
F22 Persistent delusional disorders
0.641 0.359 0.000
Q24.5 Malformation of coronary vessels
0.641 0.359 0.000
G54 Nerve root and plexus disorders
0.640 0.360 0.000
J34 Other disorders of nose and nasal sinuses
0.639 0.361 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.638 0.362 0.000
D84.1 Defects in the complement system
0.638 0.362 0.000
E28.3 Primary ovarian failure
0.637 0.363 0.000
J34.8 Other specified disorders of nose and nasal sinuses
0.633 0.367 0.000
M86.93 Osteomyelitis, unspecified (Forearm)
0.633 0.367 0.000
M86.92 Osteomyelitis, unspecified (Upper arm)
0.633 0.367 0.000
M86.91 Osteomyelitis, unspecified (Shoulder region)
0.633 0.367 0.000
M86.90 Osteomyelitis, unspecified (Multiple sites)
0.633 0.367 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.633 0.367 0.000
S21 Open wound of thorax
0.632 0.368 0.000
I82.8 Embolism and thrombosis of other specified veins
0.632 0.368 0.000
D86.8 Sarcoidosis of other and combined sites
0.632 0.368 0.000
M13.8 Other specified arthritis
0.632 0.368 0.000
M11 Other crystal arthropathies
0.631 0.369 0.000
E31.0 Autoimmune polyglandular failure
0.631 0.369 0.000
S02.00 Fracture of vault of skull (closed)
0.631 0.369 0.000
I10 Essential (primary) hypertension
0.631 0.369 0.000
G57 Mononeuropathies of lower limb
0.631 0.369 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.630 0.370 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.630 0.370 0.000
S08 Traumatic amputation of part of head
0.630 0.370 0.000
S07 Crushing injury of head
0.630 0.370 0.000
S04 Injury of cranial nerves
0.630 0.370 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.630 0.370 0.000
J91 Pleural effusion in conditions classified elsewhere
0.630 0.370 0.000
S06.8 Other intracranial injuries
0.629 0.371 0.000
Q50-Q56 Congenital malformations of genital organs
0.629 0.371 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.628 0.372 0.000
S02.6 Fracture of mandible
0.628 0.372 0.000
E29 Testicular dysfunction
0.628 0.372 0.000
Q74 Other congenital malformations of limb(s)
0.627 0.373 0.000
E24.2 Drug-induced Cushing's syndrome
0.627 0.373 0.000
M71.26 Synovial cyst of popliteal space [Baker]-Lower Leg
0.626 0.374 0.000
Q21.0 Ventricular septal defect
0.626 0.374 0.000
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.626 0.374 0.000
I15.1 Hypertension secondary to other renal disorders
0.625 0.375 0.000
M88.9 Paget's disease of bone, unspecified
0.625 0.375 0.000
S14 Injury of nerves and spinal cord at neck level
0.625 0.375 0.000
M40-M43 Deforming dorsopathies
0.625 0.375 0.000
J39 Other diseases of upper respiratory tract
0.625 0.375 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.623 0.376 0.000
F33 Recurrent depressive disorder
0.623 0.377 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.622 0.378 0.000
T33-T35 Frostbite
0.622 0.378 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.622 0.378 0.000
J64 Unspecified pneumoconiosis
0.622 0.378 0.000
M85.65 Other cyst of bone (Pelvic region and thigh)
0.621 0.379 0.000
E46 Unspecified protein-energy malnutrition
0.621 0.379 0.000
M91-M94 Chondropathies
0.620 0.379 0.000
S06.3 Focal brain injury
0.620 0.379 0.000
G58.7 Mononeuritis multiplex
0.620 0.380 0.000
E11.6 With other specified complications
0.620 0.380 0.000
D56 Thalassaemia
0.619 0.381 0.000
Q23 Congenital malformations of aortic and mitral valves
0.618 0.382 0.000
G03 Meningitis due to other and unspecified causes
0.617 0.383 0.000
Q76 Congenital malformations of spine and bony thorax
0.617 0.383 0.000
S40-S49 Injuries to the shoulder and upper arm
0.616 0.384 0.000
S02.50 Fracture of tooth (closed)
0.616 0.384 0.000
T21 Burn and corrosion of trunk
0.616 0.384 0.000
Q75 Other congenital malformations of skull and face bones
0.615 0.385 0.000
Q73 Reduction defects of unspecified limb
0.615 0.385 0.000
Q72 Reduction defects of lower limb
0.615 0.385 0.000
Q71 Reduction defects of upper limb
0.615 0.385 0.000
Q69 Polydactyly
0.615 0.385 0.000
Q68 Other congenital musculoskeletal deformities
0.615 0.385 0.000
J33.9 Nasal polyp, unspecified
0.614 0.386 0.000
E11.8 With unspecified complications
0.613 0.387 0.000
Q24.0 Dextrocardia
0.613 0.387 0.000
M71.9 Bursopathy, unspecified
0.612 0.387 0.000
E07 Other disorders of thyroid
0.612 0.388 0.000
I87.8 Other specified disorders of veins
0.612 0.388 0.000
S06.60 Traumatic subarachnoid haemorrhage (without open intracranial wound)
0.611 0.389 0.000
Q80-Q89 Other congenital malformations
0.611 0.389 0.000
G73 Disorders of myoneural junction and muscle in diseases classified elsewhere
0.610 0.389 0.000
M12.8 Other specific arthropathies, not elsewhere classified
0.610 0.390 0.000
M12.5 Traumatic arthropathy
0.610 0.390 0.000
M12.4 Intermittent hydrarthrosis
0.610 0.390 0.000
M12.1 Kaschin-Beck disease
0.610 0.390 0.000
M12.0 Chronic postrheumatic arthropathy [Jaccoud]
0.610 0.390 0.000
S02.21 Fracture of nasal bones (open)
0.609 0.391 0.000
M10 Gout
0.609 0.391 0.000
Q25.9 Congenital malformation of great arteries, unspecified
0.609 0.391 0.000
Q25.8 Other congenital malformations of great arteries
0.609 0.391 0.000
Q25.7 Other congenital malformations of pulmonary artery
0.609 0.391 0.000
Q25.5 Atresia of pulmonary artery
0.609 0.391 0.000
Q25.3 Stenosis of aorta
0.609 0.391 0.000
Q25.2 Atresia of aorta
0.609 0.391 0.000
Q25.0 Patent ductus arteriosus
0.609 0.391 0.000
J60 Coalworker's pneumoconiosis
0.609 0.391 0.000
E26.9 Hyperaldosteronism, unspecified
0.608 0.392 0.000
S10 Superficial injury of neck
0.608 0.392 0.000
J70 Respiratory conditions due to other external agents
0.608 0.392 0.000
T71 Asphyxiation
0.608 0.392 0.000
S50-S59 Injuries to the elbow and forearm
0.607 0.393 0.000
M75.3 Calcific tendinitis of shoulder
0.607 0.393 0.000
M14 Arthropathies in other diseases classified elsewhere
0.606 0.394 0.000
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities
0.606 0.394 0.000
T25 Burn and corrosion of ankle and foot
0.605 0.395 0.000
E27.8 Other specified disorders of adrenal gland
0.605 0.395 0.000
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.605 0.395 0.000
M07.34 Other psoriatic arthropathies (Hand)
0.605 0.395 0.000
M07.33 Other psoriatic arthropathies (Forearm)
0.605 0.395 0.000
M07.32 Other psoriatic arthropathies (Upper arm)
0.605 0.395 0.000
M07.31 Other psoriatic arthropathies (Shoulder region)
0.605 0.395 0.000
T66 Unspecified effects of radiation
0.604 0.395 0.000
M86.94 Osteomyelitis, unspecified (Hand)
0.603 0.396 0.000
S06.7 Intracranial injury with prolonged coma
0.603 0.397 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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