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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2523485
log Bayes Factor = 76.782
Chromosome 6   position 31,351,035  (GRCh37) Explore rs2523485 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.001 0.999
I25.1 Atherosclerotic heart disease
0.000 0.001 0.999
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.002 0.998
E14.9 Without complications
0.000 0.003 0.997
I25.2 Old myocardial infarction
0.000 0.003 0.997
E70-E90 Metabolic disorders
0.000 0.005 0.995
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.006 0.994
I10 Essential (primary) hypertension
0.000 0.008 0.992
E10.1 With ketoacidosis
0.000 0.010 0.990
E05.9 Thyrotoxicosis, unspecified
0.000 0.013 0.987
I24 Other acute ischaemic heart diseases
0.000 0.014 0.986
I22 Subsequent myocardial infarction
0.000 0.018 0.982
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.023 0.977
E78.5 Hyperlipidaemia, unspecified
0.000 0.025 0.975
I10-I15 Hypertensive diseases
0.000 0.029 0.971
I25.5 Ischaemic cardiomyopathy
0.000 0.035 0.965
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.037 0.963
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.040 0.960
E78.2 Mixed hyperlipidaemia
0.000 0.048 0.952
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.052 0.948
L40-L45 Papulosquamous disorders
0.000 0.054 0.946
J45.9 Asthma, unspecified
0.000 0.057 0.943
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.059 0.941
E10.4 With neurological complications
0.000 0.065 0.935
I20 Angina pectoris
0.000 0.069 0.931
L43 Lichen planus
0.000 0.076 0.924
E11.1 With ketoacidosis
0.000 0.076 0.924
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.084 0.916
I12 Hypertensive renal disease
0.000 0.086 0.914
E78.8 Other disorders of lipoprotein metabolism
0.000 0.088 0.912
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.090 0.910
E11.0 With coma
0.000 0.095 0.905
L43.9 Lichen planus, unspecified
0.000 0.098 0.902
I24.8 Other forms of acute ischaemic heart disease
0.000 0.103 0.897
I21 Acute myocardial infarction
0.000 0.114 0.886
E07 Other disorders of thyroid
0.000 0.115 0.885
I20.9 Angina pectoris, unspecified
0.000 0.116 0.884
E14.3 With ophthalmic complications
0.000 0.119 0.881
G35-G37 Demyelinating diseases of the central nervous system
0.879 0.121 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.123 0.877
Chapter IX Diseases of the circulatory system
0.000 0.128 0.872
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.140 0.860
E16 Other disorders of pancreatic internal secretion
0.000 0.144 0.856
I12.9 Hypertensive renal disease without renal failure
0.000 0.149 0.851
E10.8 With unspecified complications
0.000 0.149 0.851
I20.0 Unstable angina
0.000 0.153 0.847
E10.2 With renal complications
0.000 0.153 0.847
G37 Other demyelinating diseases of central nervous system
0.843 0.157 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.161 0.839
L40.8 Other psoriasis
0.000 0.165 0.835
E74 Other disorders of carbohydrate metabolism
0.000 0.172 0.828
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.174 0.826
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.175 0.825
I21.4 Acute subendocardial myocardial infarction
0.000 0.179 0.821
E07.9 Disorder of thyroid, unspecified
0.000 0.179 0.821
E16.2 Hypoglycaemia, unspecified
0.000 0.184 0.816
E11.2 With renal complications
0.000 0.188 0.812
L40.0 Psoriasis vulgaris
0.000 0.191 0.809
I23 Certain current complications following acute myocardial infarction
0.000 0.192 0.808
I21.9 Acute myocardial infarction, unspecified
0.000 0.200 0.800
G37.9 Demyelinating disease of central nervous system, unspecified
0.799 0.201 0.000
I15 Secondary hypertension
0.000 0.203 0.797
M06 Other rheumatoid arthritis
0.000 0.204 0.796
E11.5 With peripheral circulatory complications
0.000 0.214 0.786
E10.5 With peripheral circulatory complications
0.000 0.215 0.785
E10.0 With coma
0.000 0.216 0.784
E85 Amyloidosis
0.000 0.218 0.782
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.227 0.773
E13 Other specified diabetes mellitus
0.000 0.230 0.770
E78.1 Pure hyperglyceridaemia
0.000 0.236 0.764
E14.4 With neurological complications
0.000 0.245 0.755
I12.0 Hypertensive renal disease with renal failure
0.000 0.252 0.748
L43.8 Other lichen planus
0.000 0.255 0.745
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.256 0.744
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.257 0.743
I22.8 Subsequent myocardial infarction of other sites
0.000 0.258 0.742
E50-E64 Other nutritional deficiencies
0.000 0.259 0.741
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.266 0.734
E10.6 With other specified complications
0.000 0.272 0.728
E11.3 With ophthalmic complications
0.000 0.274 0.726
E11.4 With neurological complications
0.000 0.275 0.725
G37.8 Other specified demyelinating diseases of central nervous system
0.724 0.276 0.000
L42 Pityriasis rosea
0.000 0.279 0.720
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.282 0.718
E10.7 With multiple complications
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E78.6 Lipoprotein deficiency
0.000 0.283 0.717
E78.3 Hyperchylomicronaemia
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.284 0.716
E14.7 With multiple complications
0.000 0.284 0.716
E14.6 With other specified complications
0.000 0.284 0.716
E14.5 With peripheral circulatory complications
0.000 0.284 0.716
E14.2 Withrenal complications
0.000 0.284 0.716
E14.1 With ketoacidosis
0.000 0.284 0.716
E14.0 With coma
0.000 0.284 0.716
E79 Disorders of purine and pyrimidine metabolism
0.000 0.286 0.713
E77 Disorders of glycoprotein metabolism
0.000 0.286 0.713
E76 Disorders of glycosaminoglycan metabolism
0.000 0.286 0.713
E72 Other disorders of amino-acid metabolism
0.000 0.286 0.713
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.286 0.713
E70 Disorders of aromatic amino-acid metabolism
0.000 0.286 0.713
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.286 0.713
E05.5 Thyroid crisis or storm
0.000 0.287 0.712
E05.4 Thyrotoxicosis factitia
0.000 0.287 0.712
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.287 0.712
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.287 0.712
E11.6 With other specified complications
0.000 0.289 0.711
E40-E46 Malnutrition
0.000 0.290 0.710
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.290 0.710
E78.4 Other hyperlipidaemia
0.000 0.290 0.709
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.292 0.708
E05.8 Other thyrotoxicosis
0.000 0.292 0.707
I25.3 Aneurysm of heart
0.000 0.297 0.703
E83 Disorders of mineral metabolism
0.552 0.299 0.149
I13 Hypertensive heart and renal disease
0.000 0.304 0.696
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.307 0.693
E84 Cystic fibrosis
0.000 0.308 0.692
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.311 0.689
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.316 0.684
M06.3 Rheumatoid nodule
0.000 0.316 0.684
L44 Other papulosquamous disorders
0.000 0.322 0.678
L41 Parapsoriasis
0.000 0.322 0.678
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.322 0.678
I15.1 Hypertension secondary to other renal disorders
0.000 0.327 0.673
E61 Deficiency of other nutrient elements
0.000 0.328 0.672
I23.8 Other current complications following acute myocardial infarction
0.000 0.329 0.671
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.332 0.668
L40.3 Pustulosis palmaris et plantaris
0.000 0.333 0.667
I24.1 Dressler's syndrome
0.000 0.336 0.664
L43.3 Subacute (active) lichen planus
0.000 0.337 0.662
L43.2 Lichenoid drug reaction
0.000 0.337 0.662
L43.1 Bullous lichen planus
0.000 0.337 0.662
L43.0 Hypertrophic lichen planus
0.000 0.337 0.662
E11.8 With unspecified complications
0.000 0.338 0.662
E03.8 Other specified hypothyroidism
0.000 0.338 0.662
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.338 0.661
E06 Thyroiditis
0.000 0.341 0.659
E15 Nondiabetic hypoglycaemic coma
0.000 0.343 0.657
I11 Hypertensive heart disease
0.000 0.348 0.652
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.365 0.635
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.365 0.635
E07.1 Dyshormogenetic goitre
0.000 0.365 0.635
E07.0 Hypersecretion of calcitonin
0.000 0.365 0.635
G36 Other acute disseminated demyelination
0.630 0.370 0.000
E61.1 Iron deficiency
0.000 0.374 0.626
M45 Ankylosing spondylitis
0.000 0.378 0.622
E85.9 Amyloidosis, unspecified
0.000 0.383 0.617
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.386 0.613
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.386 0.613
E16.4 Abnormal secretion of gastrin
0.000 0.386 0.613
E16.3 Increased secretion of glucagon
0.000 0.386 0.613
E16.1 Other hypoglycaemia
0.000 0.386 0.613
E85.4 Organ-limited amyloidosis
0.000 0.387 0.613
M05-M14 Inflammatory polyarthropathies
0.000 0.393 0.607
E13.9 Without complications
0.000 0.394 0.606
M06.4 Inflammatory polyarthropathy
0.000 0.395 0.605
G37.5 Concentric sclerosis [Balo]
0.604 0.396 0.000
G37.4 Subacute necrotising myelitis
0.604 0.396 0.000
G37.2 Central pontine myelinolysis
0.604 0.396 0.000
G37.1 Central demyelination of corpus callosum
0.604 0.396 0.000
G37.0 Diffuse sclerosis
0.604 0.396 0.000
E73 Lactose intolerance
0.000 0.397 0.603
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.406 0.594
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.406 0.594
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.406 0.594
E74.2 Disorders of galactose metabolism
0.000 0.406 0.594
E74.1 Disorders of fructose metabolism
0.000 0.406 0.594
E74.0 Glycogen storage disease
0.000 0.406 0.594
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.407 0.593
I00-I02 Acute rheumatic fever
0.000 0.410 0.590
M06.34 Rheumatoid nodule (Hand)
0.000 0.415 0.585
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.420 0.579
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.420 0.579
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.420 0.579
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.420 0.579
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.420 0.579
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.420 0.579
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.420 0.579
E20-E35 Disorders of other endocrine glands
0.000 0.426 0.574
M07 Psoriatic and enteropathic arthropathies
0.000 0.428 0.572
I15.9 Seconday hypertension, unspecified
0.000 0.428 0.572
I15.8 Other secondary hypertension
0.000 0.428 0.572
I15.2 Hypertension secondary to endocrine disorders
0.000 0.428 0.572
I15.0 Renovascular hypertension
0.000 0.428 0.572
M06.8 Other specified rheumatoid arthritis
0.000 0.429 0.570
M06.2 Rheumatoid bursitis
0.000 0.429 0.570
M06.1 Adult-onset Still's disease
0.000 0.429 0.570
E07.8 Other specified disorders of thyroid
0.000 0.434 0.566
I20.1 Angina pectoris with documented spasm
0.000 0.439 0.561
E85.8 Other amyloidosis
0.000 0.439 0.561
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.439 0.561
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.439 0.561
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.439 0.561
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.561 0.439 0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.442 0.557
E89.3 Postprocedural hypopituitarism
0.000 0.447 0.553
E13.8 With unspecified complications
0.000 0.447 0.552
E13.7 With multiple complications
0.000 0.447 0.552
E13.6 With other specified complications
0.000 0.447 0.552
E13.5 With peripheral circulatory complications
0.000 0.447 0.552
E13.4 With neurological complications
0.000 0.447 0.552
E13.3 With ophthalmic complications
0.000 0.447 0.552
E13.2 With renal complications
0.000 0.447 0.552
E13.1 With ketoacidosis
0.000 0.447 0.552
E13.0 With coma
0.000 0.447 0.552
M07.3 Other psoriatic arthropathies
0.000 0.448 0.552
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.458 0.542
I25.4 Coronary artery aneurysm
0.000 0.463 0.537
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.463 0.537
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.469 0.531
E63 Other nutritional deficiencies
0.000 0.469 0.531
E56 Other vitamin deficiencies
0.000 0.469 0.531
E51 Thiamine deficiency
0.000 0.469 0.531
E50 Vitamin A deficiency
0.000 0.469 0.531
E60 Dietary zinc deficiency
0.000 0.469 0.531
E59 Dietary selenium deficiency
0.000 0.469 0.531
E58 Dietary calcium deficiency
0.000 0.469 0.531
E54 Ascorbic acid deficiency
0.000 0.469 0.531
E52 Niacin deficiency [pellagra]
0.000 0.469 0.531
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.471 0.529
E83.3 Disorders of phosphorus metabolism
0.472 0.477 0.051
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.482 0.518
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.483 0.517
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E85.3 Secondary systemic amyloidosis
0.000 0.486 0.514
K51 Ulcerative colitis
0.513 0.487 0.000
M05 Seropositive rheumatoid arthritis
0.000 0.487 0.512
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.488 0.512
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.488 0.512
E70.3 Albinism
0.000 0.488 0.512
E70.2 Disorders of tyrosine metabolism
0.000 0.488 0.512
E70.1 Other hyperphenylalaninaemias
0.000 0.488 0.512
E70.0 Classical phenylketonuria
0.000 0.488 0.512
E71.3 Disorders of fatty-acid metabolism
0.000 0.488 0.512
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.488 0.512
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.488 0.512
E71.0 Maple-syrup-urine disease
0.000 0.488 0.512
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.488 0.512
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.488 0.512
E72.5 Disorders of glycine metabolism
0.000 0.488 0.512
E72.4 Disorders of ornithine metabolism
0.000 0.488 0.512
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.488 0.512
E72.2 Disorders of urea cycle metabolism
0.000 0.488 0.512
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.488 0.512
E72.0 Disorders of amino-acid transport
0.000 0.488 0.512
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.488 0.512
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.488 0.512
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.488 0.512
E76.2 Other mucopolysaccharidoses
0.000 0.488 0.512
E76.1 Mucopolysaccharidosis, type II
0.000 0.488 0.512
E76.0 Mucopolysaccharidosis, type I
0.000 0.488 0.512
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.488 0.512
E77.8 Other disorders of glycoprotein metabolism
0.000 0.488 0.512
E77.1 Defects in glycoprotein degradation
0.000 0.488 0.512
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.488 0.512
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.488 0.512
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.488 0.512
E79.1 Lesch-Nyhan syndrome
0.000 0.488 0.512
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.488 0.512
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.490 0.509
E45 Retarded development following protein-energy malnutrition
0.000 0.490 0.509
E43 Unspecified severe protein-energy malnutrition
0.000 0.490 0.509
E42 Marasmic kwashiorkor
0.000 0.490 0.509
E41 Nutritional marasmus
0.000 0.490 0.509
E40 Kwashiorkor
0.000 0.490 0.509
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.492 0.508
E46 Unspecified protein-energy malnutrition
0.000 0.497 0.503
E83.9 Disorder of mineral metabolism, unspecified
0.396 0.497 0.107
E83.8 Other disorders of mineral metabolism
0.396 0.497 0.107
E83.2 Disorders of zinc metabolism
0.396 0.497 0.107
E83.0 Disorders of copper metabolism
0.396 0.497 0.107
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.501 0.499
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.501 0.499
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.501 0.499
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.501 0.499
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.501 0.499
K51.3 Ulcerative (chronic) rectosigmoiditis
0.499 0.501 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.503 0.497
E84.8 Cystic fibrosis with other manifestations
0.000 0.504 0.496
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.504 0.496
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.504 0.496
K51.4 Pseudopolyposis of colon
0.493 0.507 0.000
K51.9 Ulcerative colitis, unspecified
0.492 0.508 0.000
E75.6 Lipid storage disorder, unspecified
0.000 0.509 0.491
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.509 0.491
E75.3 Sphingolipidosis, unspecified
0.000 0.509 0.491
E75.2 Other sphingolipidosis
0.000 0.509 0.491
E75.1 Other gangliosidosis
0.000 0.509 0.491
E75.0 GM2 gangliosidosis
0.000 0.509 0.491
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.509 0.491
M06.38 Rheumatoid nodule (Other)
0.000 0.509 0.491
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.509 0.491
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.509 0.491
M06.33 Rheumatoid nodule (Forearm)
0.000 0.509 0.491
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.509 0.491
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.509 0.491
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.509 0.491
E55 Vitamin D deficiency
0.000 0.513 0.487
L41.9 Parapsoriasis, unspecified
0.000 0.514 0.486
L41.8 Other parapsoriasis
0.000 0.514 0.486
L41.5 Retiform parapsoriasis
0.000 0.514 0.486
L41.4 Large plaque parapsoriasis
0.000 0.514 0.486
L41.3 Small plaque parapsoriasis
0.000 0.514 0.486
L41.2 Lymphomatoid papulosis
0.000 0.514 0.486
L41.1 Pityriasis lichenoides chronica
0.000 0.514 0.486
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.514 0.486
L44.9 Papulosquamous disorder, unspecified
0.000 0.514 0.486
L44.8 Other specified papulosquamous disorders
0.000 0.514 0.486
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.514 0.486
L44.3 Lichen ruber moniliformis
0.000 0.514 0.486
L44.2 Lichen striatus
0.000 0.514 0.486
L44.1 Lichen nitidus
0.000 0.514 0.486
L44.0 Pityriasis rubra pilaris
0.000 0.514 0.486
K51.8 Other ulcerative colitis
0.482 0.518 0.000
E61.9 Deficiency of nutrient element, unspecified
0.000 0.518 0.482
E61.8 Deficiency of other specified nutrient elements
0.000 0.518 0.482
E61.7 Deficiency of multiple nutrient elements
0.000 0.518 0.482
E61.6 Vanadium deficiency
0.000 0.518 0.482
E61.5 Molybdenum deficiency
0.000 0.518 0.482
E61.4 Chromium deficiency
0.000 0.518 0.482
E61.3 Manganese deficiency
0.000 0.518 0.482
E61.0 Copper deficiency
0.000 0.518 0.482
E65-E68 Obesity and other hyperalimentation
0.000 0.522 0.478
E84.9 Cystic fibrosis, unspecified
0.000 0.526 0.474
E06.9 Thyroiditis, unspecified
0.000 0.526 0.473
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.527 0.473
E06.5 Other chronic thyroiditis
0.000 0.527 0.473
E06.4 Drug-induced thyroiditis
0.000 0.527 0.473
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.527 0.473
E06.1 Subacute thyroiditis
0.000 0.527 0.473
E06.0 Acute thyroiditis
0.000 0.527 0.473
E61.2 Magnesium deficiency
0.000 0.529 0.471
E23 Hypofunction and other disorders of pituitary gland
0.000 0.529 0.471
E75.5 Other lipid storage disorders
0.000 0.539 0.461
M45-M49 Spondylopathies
0.000 0.540 0.460
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.540 0.460
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.541 0.459
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.545 0.455
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.545 0.455
E89.5 Postprocedural testicular hypofunction
0.000 0.545 0.455
E89.1 Postprocedural hypoinsulinaemia
0.000 0.545 0.455
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.545 0.455
M79.6 Pain in limb
0.000 0.545 0.455
G36.9 Acute disseminated demyelination, unspecified
0.452 0.548 0.000
G36.8 Other specified acute disseminated demyelination
0.452 0.548 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.452 0.548 0.000
G36.0 Neuromyelitis optica [Devic]
0.452 0.548 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.548 0.452
M70-M79 Other soft tissue disorders
0.000 0.550 0.450
E28 Ovarian dysfunction
0.000 0.551 0.449
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.551 0.449
M79 Other soft tissue disorders, not elsewhere classified
0.000 0.552 0.448
M79.65 Pain in limb (Pelvic region and thigh)
0.000 0.553 0.447
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.554 0.446
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.554 0.446
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.554 0.446
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.554 0.446
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.554 0.446
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.554 0.446
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.554 0.446
E89.4 Postprocedural ovarian failure
0.000 0.557 0.443
E89.2 Postprocedural hypoparathyroidism
0.000 0.559 0.441
E88 Other metabolic disorders
0.000 0.560 0.440
E24 Cushing's syndrome
0.000 0.561 0.439
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.565 0.435
M08 Juvenile arthritis
0.000 0.565 0.435
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.566 0.434
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.566 0.434
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.566 0.434
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.566 0.434
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.566 0.434
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.566 0.434
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.566 0.434
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.566 0.434
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.567 0.432
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.568 0.432
E73.8 Other lactose intolerance
0.000 0.568 0.432
E73.1 Secondary lactase deficiency
0.000 0.568 0.432
E73.0 Congenital lactase deficiency
0.000 0.568 0.432
K51.5 Mucosal proctocolitis
0.430 0.570 0.000
E22 Hyperfunction of pituitary gland
0.000 0.570 0.430
M79.62 Pain in limb (Upper arm)
0.000 0.573 0.427
E29 Testicular dysfunction
0.000 0.574 0.426
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.575 0.425
I02 Rheumatic chorea
0.000 0.577 0.423
I01 Rheumatic fever with heart involvement
0.000 0.577 0.423
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.578 0.422
M79.67 Pain in limb (Ankle and foot)
0.000 0.578 0.422
M79.7 Fibromyalgia
0.000 0.579 0.421
K51.2 Ulcerative (chronic) proctitis
0.419 0.581 0.000
E06.3 Autoimmune thyroiditis
0.000 0.586 0.414
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.588 0.412
E32 Diseases of thymus
0.000 0.588 0.412
E31 Polyglandular dysfunction
0.000 0.588 0.412
E30 Disorders of puberty, not elsewhere classified
0.000 0.588 0.412
E25 Adrenogenital disorders
0.000 0.588 0.412
M07.5 Arthropathy in ulcerative colitis
0.000 0.589 0.410
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.589 0.410
M07.2 Psoriatic spondylitis
0.000 0.589 0.410
M07.1 Arthritis mutilans
0.000 0.589 0.410
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.589 0.410
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.591 0.409
M06.18 Adult-onset Still's disease (Other)
0.000 0.591 0.409
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.591 0.409
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.591 0.409
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.591 0.409
M06.14 Adult-onset Still's disease (Hand)
0.000 0.591 0.409
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.591 0.409
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.591 0.409
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.591 0.409
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.591 0.409
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.591 0.409
M06.28 Rheumatoid bursitis (Other)
0.000 0.591 0.409
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.591 0.409
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.591 0.409
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.591 0.409
M06.24 Rheumatoid bursitis (Hand)
0.000 0.591 0.409
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.591 0.409
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.591 0.409
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.591 0.409
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.591 0.409
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.591 0.409
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.591 0.409
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.591 0.409
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.591 0.409
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.591 0.409
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.591 0.409
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.591 0.409
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.591 0.409
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.591 0.409
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.591 0.409
E83.5 Disorders of calcium metabolism
0.395 0.591 0.014
M79.79 Fibromyalgia (Site unspecified)
0.000 0.596 0.404
M79.1 Myalgia
0.000 0.599 0.401
E26 Hyperaldosteronism
0.000 0.600 0.400
M11 Other crystal arthropathies
0.000 0.603 0.397
E23.7 Disorder of pituitary gland, unspecified
0.000 0.603 0.397
M75 Shoulder lesions
0.000 0.603 0.397
M07.38 Other psoriatic arthropathies (Other)
0.000 0.604 0.396
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.604 0.396
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.604 0.396
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.604 0.396
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.604 0.396
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.604 0.396
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.604 0.396
M70 Soft tissue disorders related to use, overuse and pressure
0.000 0.606 0.394
K51.0 Ulcerative (chronic) enterocolitis
0.392 0.608 0.000
# Top node
0.000 0.611 0.389
I00 Rheumatic fever without mention of heart involvement
0.000 0.612 0.387

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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