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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs28459416
log Bayes Factor = 7.94577
Chromosome 15   position 99,561,550  (GRCh37) Explore rs28459416 on Ensembl!
Variant rs28459416 is part of Cluster X0117

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter II Neoplasms
1.000 0.000 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
1.000 0.000 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.998 0.002 0.000
Chapter VI Diseases of the nervous system
0.998 0.002 0.000
Chapter I Certain infectious and parasitic diseases
0.997 0.003 0.000
B95-B98 Bacterial, viral and other infectious agents
0.996 0.004 0.000
Chapter V Mental and behavioural disorders
0.994 0.006 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.994 0.006 0.000
Chapter XX External causes of morbidity and mortality
0.992 0.008 0.000
Chapter XXII Codes for special purposes
0.987 0.013 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.987 0.013 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.986 0.014 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.985 0.015 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.981 0.019 0.000
B96.1 Klebsiella pneumoniae [K. pneumoniae] as the cause of diseases classified to other chapters
0.979 0.021 0.000
B96.2 Escherichia coli [E. coli] as the cause of diseases classified to other chapters
0.978 0.022 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.977 0.023 0.000
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum
0.975 0.025 0.000
C51-C58 Malignant neoplasms of female genital organs
0.975 0.025 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.967 0.033 0.000
C56 Malignant neoplasm of ovary
0.962 0.038 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.961 0.039 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.957 0.043 0.000
Chapter IX Diseases of the circulatory system
0.957 0.043 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.954 0.046 0.000
Y40 Systemic antibiotics
0.953 0.047 0.000
C78.0 Secondary malignant neoplasm of lung
0.951 0.049 0.000
I60-I69 Cerebrovascular diseases
0.950 0.050 0.000
G62 Other polyneuropathies
0.949 0.051 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.944 0.056 0.000
U80 Agent resistant to penicillin and related antibiotics
0.941 0.059 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.933 0.067 0.000
C15-C26 Malignant neoplasms of digestive organs
0.930 0.070 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.929 0.071 0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs
0.929 0.071 0.000
G80 Infantile cerebral palsy
0.928 0.072 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.923 0.077 0.000
U80.1 Methicillin resistant agent
0.920 0.080 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.919 0.081 0.000
F43 Reaction to severe stress, and adjustment disorders
0.917 0.083 0.000
G83 Other paralytic syndromes
0.915 0.085 0.000
I26 Pulmonary embolism
0.914 0.086 0.000
G62.9 Polyneuropathy, unspecified
0.911 0.089 0.000
F41 Other anxiety disorders
0.911 0.089 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.907 0.093 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.906 0.094 0.000
Y40.0 Penicillins
0.904 0.096 0.000
Y40.9 Systemic antibiotic, unspecified
0.901 0.099 0.000
A30-A49 Other bacterial diseases
0.900 0.100 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.897 0.103 0.000
C91 Lymphoid leukaemia
0.896 0.104 0.000
D68 Other coagulation defects
0.895 0.105 0.000
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.891 0.109 0.000
I62 Other nontraumatic intracranial haemorrhage
0.888 0.112 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.886 0.114 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.885 0.115 0.000
F41.9 Anxiety disorder, unspecified
0.883 0.117 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.882 0.118 0.000
B95.7 Other staphylococcus as the cause of diseases classified to other chapters
0.882 0.118 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.878 0.122 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.876 0.124 0.000
I05-I09 Chronic rheumatic heart diseases
0.875 0.125 0.000
C80 Malignant neoplasm without specification of site
0.873 0.127 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.868 0.132 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.868 0.132 0.000
Y95 Nosocomial condition
0.867 0.133 0.000
G70-G73 Diseases of myoneural junction and muscle
0.865 0.135 0.000
F42 Obsessive-compulsive disorder
0.864 0.136 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.864 0.136 0.000
G80.9 Infantile cerebral palsy, unspecified
0.864 0.136 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.861 0.139 0.000
A80-A89 Viral infections of the central nervous system
0.861 0.139 0.000
C91.1 Chronic lymphocytic leukaemia
0.859 0.141 0.000
S90-S99 Injuries to the ankle and foot
0.859 0.141 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.857 0.142 0.000
C78.1 Secondary malignant neoplasm of mediastinum
0.857 0.143 0.000
F40 Phobic anxiety disorders
0.856 0.144 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.855 0.145 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.852 0.148 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
0.852 0.148 0.000
G90-G99 Other disorders of the nervous system
0.851 0.149 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.845 0.155 0.000
D68.2 Hereditary deficiency of other clotting factors
0.844 0.156 0.000
C26.0 Intestinal tract, part unspecified
0.841 0.159 0.000
Chapter VIII Diseases of the ear and mastoid process
0.840 0.160 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.839 0.161 0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters
0.833 0.167 0.000
F43.1 Posttraumatic stress disorder
0.832 0.168 0.000
C77.0 Lymph nodes of head, face and neck
0.830 0.170 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.829 0.171 0.000
F03 Unspecified dementia
0.826 0.174 0.000
C69 Malignant neoplasm of eye and adnexa
0.826 0.174 0.000
B95.0 Streptococcus, group A, as the cause of diseases classified to other chapters
0.825 0.175 0.000
B95.4 Other streptococcus as the cause of diseases classified to other chapters
0.823 0.177 0.000
F30-F39 Mood [affective] disorders
0.821 0.179 0.000
I67 Other cerebrovascular diseases
0.818 0.182 0.000
G82 Paraplegia and tetraplegia
0.817 0.183 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.817 0.183 0.000
G30-G32 Other degenerative diseases of the nervous system
0.815 0.185 0.000
I62.0 Subdural haemorrhage (acute) (nontraumatic)
0.815 0.185 0.000
F60-F69 Disorders of adult personality and behaviour
0.814 0.185 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.813 0.187 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.811 0.189 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.810 0.190 0.000
G83.4 Cauda equina syndrome
0.808 0.192 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.806 0.194 0.000
G62.0 Drug-induced polyneuropathy
0.805 0.195 0.000
C16 Malignant neoplasm of stomach
0.805 0.195 0.000
C77.1 Intrathoracic lymph nodes
0.801 0.199 0.000
C71 Malignant neoplasm of brain
0.799 0.201 0.000
B96.3 Haemophilus influenzae [H. influenzae] as the cause of diseases classified to other chapters
0.799 0.201 0.000
S00-S09 Injuries to the head
0.799 0.201 0.000
B99-B99 Other infectious diseases
0.798 0.202 0.000
I69 Sequelae of cerebrovascular disease
0.798 0.202 0.000
C34 Malignant neoplasm of bronchus and lung
0.796 0.204 0.000
X60-X84 Intentional self-harm
0.792 0.208 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.791 0.209 0.000
F00 Dementia in Alzheimer's disease
0.791 0.209 0.000
I63 Cerebral infarction
0.790 0.210 0.000
G72 Other myopathies
0.789 0.211 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.785 0.215 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.785 0.215 0.000
B96.4 Proteus (mirabilis)(morganii) as the cause of diseases classified to other chapters
0.785 0.215 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.785 0.215 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.784 0.216 0.000
I05 Rheumatic mitral valve diseases
0.784 0.216 0.000
A41 Other septicaemia
0.784 0.216 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.781 0.219 0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified
0.779 0.221 0.000
C79 Secondary malignant neoplasm of other sites
0.779 0.221 0.000
C25 Malignant neoplasm of pancreas
0.779 0.221 0.000
F05.9 Delirium, unspecified
0.778 0.221 0.000
F42.9 Obsessive-compulsive disorder, unspecified
0.776 0.224 0.000
C55 Malignant neoplasm of uterus, part unspecified
0.775 0.225 0.000
A65-A69 Other spirochaetal diseases
0.775 0.225 0.000
S90 Superficial injury of ankle and foot
0.774 0.226 0.000
T39.1 4-Aminophenol derivatives
0.774 0.226 0.000
D68.8 Other specified coagulation defects
0.773 0.227 0.000
I63.8 Other cerebral infarction
0.773 0.227 0.000
G80.2 Infantile hemiplegia
0.772 0.228 0.000
U88 Agent resistant to multiple antibiotics
0.772 0.228 0.000
X10-X19 Contact with heat and hot substances
0.769 0.231 0.000
C48 Malignant neoplasm of retroperitoneum and peritoneum
0.767 0.233 0.000
C34.9 Bronchus or lung, unspecified
0.765 0.235 0.000
V10-V19 Pedal cyclist injured in transport accident
0.764 0.236 0.000
F43.0 Acute stress reaction
0.764 0.236 0.000
S10-S19 Injuries to the neck
0.762 0.238 0.000
C18 Malignant neoplasm of colon
0.762 0.238 0.000
I07 Rheumatic tricuspid valve diseases
0.762 0.238 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.760 0.240 0.000
I26.0 Pulmonary embolism with mention of acute cor pulmonale
0.760 0.240 0.000
V40-V49 Car occupant injured in transport accident
0.759 0.241 0.000
U80.0 Penicillin resistant agent
0.759 0.241 0.000
I61 Intracerebral haemorrhage
0.758 0.242 0.000
S02 Fracture of skull and facial bones
0.758 0.242 0.000
G61 Inflammatory polyneuropathy
0.756 0.244 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.754 0.246 0.000
B65-B83 Helminthiases
0.753 0.246 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.750 0.250 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.750 0.250 0.000
G83.8 Other specified paralytic syndromes
0.750 0.250 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.748 0.252 0.000
T46.4 Angiotensin-converting-enzyme inhibitors
0.747 0.253 0.000
A87 Viral meningitis
0.746 0.254 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.745 0.255 0.000
D68.6 Other Thrombophilia
0.744 0.256 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.742 0.258 0.000
H65-H75 Diseases of middle ear and mastoid
0.742 0.258 0.000
Y40.3 Macrolides
0.742 0.258 0.000
C18.0 Caecum
0.741 0.259 0.000
S32 Fracture of lumbar spine and pelvis
0.741 0.259 0.000
A15-A19 Tuberculosis
0.741 0.259 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.740 0.260 0.000
V01-V09 Pedestrian injured in transport accident
0.739 0.261 0.000
C53 Malignant neoplasm of cervix uteri
0.739 0.261 0.000
F41.1 Generalised anxiety disorder
0.736 0.264 0.000
C80.9 Malignant neoplasm, unspecified
0.735 0.265 0.000
G95 Other diseases of spinal cord
0.735 0.265 0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease
0.735 0.265 0.000
G72.9 Myopathy, unspecified
0.734 0.266 0.000
I62.9 Intracranial haemorrhage (nontraumatic), unspecified
0.734 0.266 0.000
X50-X57 Overexertion, travel and privation
0.733 0.267 0.000
A46 Erysipelas
0.733 0.267 0.000
F48 Other neurotic disorders
0.733 0.267 0.000
I67.8 Other specified cerebrovascular diseases
0.732 0.268 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.728 0.272 0.000
F40.2 Specific (isolated) phobias
0.728 0.272 0.000
G40-G47 Episodic and paroxysmal disorders
0.727 0.273 0.000
S20-S29 Injuries to the thorax
0.726 0.274 0.000
I69.0 Sequelae of subarachnoid haemorrhage
0.726 0.274 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.726 0.274 0.000
F02 Dementia in other diseases classified elsewhere
0.724 0.276 0.000
C69.9 Eye, unspecified
0.724 0.276 0.000
U89 Agent resistant to other and unspecified antibiotics
0.722 0.278 0.000
Y00-Y09 Assault
0.722 0.278 0.000
H90-H95 Other disorders of ear
0.719 0.281 0.000
G83.2 Monoplegia of upper limb
0.719 0.281 0.000
C07 Malignant neoplasm of parotid gland
0.718 0.281 0.000
T00-T07 Injuries involving multiple body regions
0.718 0.282 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.717 0.283 0.000
C78.4 Secondary malignant neoplasm of small intestine
0.716 0.284 0.000
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs
0.716 0.284 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.715 0.285 0.000
B50-B64 Protozoal diseases
0.715 0.285 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.715 0.285 0.000
A75-A79 Rickettsioses
0.715 0.285 0.000
A70-A74 Other diseases caused by chlamydiae
0.715 0.285 0.000
A20-A28 Certain zoonotic bacterial diseases
0.715 0.285 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.713 0.287 0.000
S90.9 Superficial injury of ankle and foot, unspecified
0.713 0.287 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.713 0.287 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.713 0.287 0.000
F70-F79 Mental retardation
0.713 0.287 0.000
B96.7 Clostridium perfringens [C. perfringens] as the cause of diseases classified to other chapters
0.712 0.288 0.000
B96.6 Bacillus fragilis [B. fragilis] as the cause of diseases classified to other chapters
0.712 0.288 0.000
B96.0 Mycoplasma pneumoniae [M. pneumoniae] as the cause of diseases classified to other chapters
0.712 0.288 0.000
T46.1 Calcium-channel blockers
0.712 0.288 0.000
Y35-Y36 Legal intervention and operations of war
0.711 0.289 0.000
Y10-Y34 Event of undetermined intent
0.711 0.289 0.000
X85-X99 Assault
0.711 0.289 0.000
X30-X39 Exposure to forces of nature
0.711 0.289 0.000
X00-X09 Exposure to smoke, fire and flames
0.711 0.289 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.711 0.289 0.000
W75-W84 Other accidental threats to breathing
0.711 0.289 0.000
W65-W74 Accidental drowning and submersion
0.711 0.289 0.000
V98-V99 Other and unspecified transport accidents
0.711 0.289 0.000
V95-V97 Air and space transport accidents
0.711 0.289 0.000
V90-V94 Water transport accidents
0.711 0.289 0.000
V70-V79 Bus occupant injured in transport accident
0.711 0.289 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.711 0.289 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.711 0.289 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.711 0.289 0.000
C80.0 Malignant neoplasm, primary site unknown, so stated
0.710 0.290 0.000
S30.8 Other superficial injuries of abdomen, lower back and pelvis
0.710 0.290 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.709 0.291 0.000
Q80-Q89 Other congenital malformations
0.709 0.291 0.000
T33-T35 Frostbite
0.707 0.293 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.707 0.293 0.000
U51 Admission status on psychiatric patients
0.707 0.293 0.000
F44 Dissociative [conversion] disorders
0.707 0.293 0.000
G30 Alzheimer's disease
0.706 0.294 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.706 0.294 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.706 0.294 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.706 0.294 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.706 0.294 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.706 0.294 0.000
S02.6 Fracture of mandible
0.705 0.295 0.000
T36 Poisoning by systemic antibiotics
0.705 0.295 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.704 0.296 0.000
T43.2 Other and unspecified antidepressants
0.703 0.297 0.000
C82.2 Large cell, follicular
0.703 0.297 0.000
A41.9 Septicaemia, unspecified
0.701 0.299 0.000
G64 Other disorders of peripheral nervous system
0.700 0.300 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.700 0.300 0.000
W50-W64 Exposure to animate mechanical forces
0.699 0.301 0.000
S70-S79 Injuries to the hip and thigh
0.699 0.301 0.000
C57 Malignant neoplasm of other and unspecified female genital organs
0.699 0.301 0.000
C58 Malignant neoplasm of placenta
0.699 0.301 0.000
C52 Malignant neoplasm of vagina
0.699 0.301 0.000
B95.2 Streptococcus, group D, as the cause of diseases classified to other chapters
0.699 0.301 0.000
A39 Meningococcal infection
0.698 0.302 0.000
C77.2 Intra-abdominal lymph nodes
0.698 0.302 0.000
C16.3 Pyloric antrum
0.698 0.302 0.000
G60 Hereditary and idiopathic neuropathy
0.698 0.302 0.000
C02 Malignant neoplasm of other and unspecified parts of tongue
0.698 0.302 0.000
T42.4 Benzodiazepines
0.697 0.303 0.000
I27 Other pulmonary heart diseases
0.694 0.305 0.000
S36 Injury of intra-abdominal organs
0.694 0.306 0.000
F33 Recurrent depressive disorder
0.694 0.306 0.000
C17 Malignant neoplasm of small intestine
0.694 0.306 0.000
G06 Intracranial and intraspinal abscess and granuloma
0.694 0.306 0.000
S50-S59 Injuries to the elbow and forearm
0.693 0.307 0.000
Y59 Other and unspecified vaccines and biological substances
0.693 0.307 0.000
Y58 Bacterial vaccines
0.693 0.307 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.693 0.307 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.693 0.307 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.693 0.307 0.000
Y48 Anaesthetics and therapeutic gases
0.692 0.308 0.000
B95.8 Unspecified staphylococcus as the cause of diseases classified to other chapters
0.692 0.308 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.691 0.309 0.000
C79.9 Secondary malignant neoplasm, unspecified site
0.690 0.310 0.000
T79-T79 Certain early complications of trauma
0.689 0.310 0.000
T40.2 Other opioids
0.689 0.311 0.000
U50 Level of care administered to neonates
0.689 0.311 0.000
U07 Emergency use of U07
0.689 0.311 0.000
U06 Emergency use of U06
0.689 0.311 0.000
U04 Severe acute respiratory syndrome [SARS]
0.689 0.311 0.000
U52 First in a series of a regular day/night admissions
0.689 0.311 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.688 0.312 0.000
U81 Agent resistant to vancomycin and related antibiotics
0.688 0.312 0.000
C78.7 Secondary malignant neoplasm of liver
0.687 0.313 0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.687 0.313 0.000
F60 Specific personality disorders
0.686 0.314 0.000
I00-I02 Acute rheumatic fever
0.686 0.314 0.000
G62.8 Other specified polyneuropathies
0.686 0.314 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.685 0.315 0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction
0.684 0.316 0.000
F09 Unspecified organic or symptomatic mental disorder
0.684 0.316 0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances
0.684 0.316 0.000
Y40.7 Antifungal antibiotics, systemically used
0.683 0.316 0.000
Y40.6 Rifamycins
0.683 0.316 0.000
Y40.5 Aminoglycosides
0.683 0.316 0.000
Y40.4 Tetracyclines
0.683 0.316 0.000
Y40.2 Chloramphenicol group
0.683 0.316 0.000
D69 Purpura and other haemorrhagic conditions
0.684 0.316 0.000
I05.2 Mitral stenosis with insufficiency
0.683 0.317 0.000
C01 Malignant neoplasm of base of tongue
0.682 0.317 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.681 0.319 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.681 0.319 0.000
G62.2 Polyneuropathy due to other toxic agents
0.680 0.320 0.000
G62.1 Alcoholic polyneuropathy
0.680 0.320 0.000
I07.1 Tricuspid insufficiency
0.680 0.320 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.680 0.320 0.000
S37 Injury of urinary and pelvic organs
0.679 0.320 0.000
F40.0 Agoraphobia
0.678 0.322 0.000
Y40.1 Cefalosporins and other -lactam antibiotics
0.678 0.322 0.000
I09 Other rheumatic heart diseases
0.678 0.322 0.000
C04 Malignant neoplasm of floor of mouth
0.678 0.322 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.677 0.323 0.000
F34 Persistent mood [affective] disorders
0.677 0.323 0.000
D68.5 Primary Thrombophilia
0.677 0.323 0.000
G83.1 Monoplegia of lower limb
0.677 0.323 0.000
C71.4 Occipital lobe
0.677 0.323 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.677 0.323 0.000
C95 Leukaemia of unspecified cell type
0.677 0.323 0.000
C94 Other leukaemias of specified cell type
0.677 0.323 0.000
C93 Monocytic leukaemia
0.677 0.323 0.000
C88 Malignant immunoproliferative diseases
0.677 0.323 0.000
C86 Other specified types of T/NK-cell lymphoma
0.677 0.323 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.677 0.323 0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.675 0.325 0.000
U80.8 Agent resistant to other penicillin-related antibiotic
0.673 0.327 0.000
V20-V29 Motorcycle rider injured in transport accident
0.673 0.327 0.000
F00.9 Dementia in Alzheimer's disease, unspecified
0.673 0.327 0.000
C34.2 Middle lobe, bronchus or lung
0.673 0.327 0.000
C82.0 Small cleaved cell, follicular
0.673 0.327 0.000
X20-X29 Contact with venomous animals and plants
0.672 0.328 0.000
D80-D89 Certain disorders involving the immune mechanism
0.671 0.329 0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.671 0.329 0.000
G82.2 Paraplegia, unspecified
0.670 0.330 0.000
C90 Multiple myeloma and malignant plasma cell neoplasms
0.669 0.330 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.669 0.331 0.000
A41.8 Other specified septicaemia
0.669 0.331 0.000
I28 Other diseases of pulmonary vessels
0.669 0.331 0.000
S02.60 Fracture of mandible (closed)
0.668 0.332 0.000
Y83.8 Other surgical procedures
0.667 0.333 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.667 0.333 0.000
C23 Malignant neoplasm of gallbladder
0.667 0.333 0.000
Y52 Agents primarily affecting the cardiovascular system
0.666 0.334 0.000
C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system
0.666 0.334 0.000
C70 Malignant neoplasm of meninges
0.666 0.334 0.000
D68.9 Coagulation defect, unspecified
0.665 0.335 0.000
G80.8 Other infantile cerebral palsy
0.665 0.335 0.000
G80.4 Ataxic cerebral palsy
0.665 0.335 0.000
G80.3 Dyskinetic cerebral palsy
0.665 0.335 0.000
G80.1 Spastic diplegia
0.665 0.335 0.000
G80.0 Spastic cerebral palsy
0.665 0.335 0.000
F43.2 Adjustment disorders
0.664 0.336 0.000
A87.9 Viral meningitis, unspecified
0.664 0.336 0.000
G95.1 Vascular myelopathies
0.662 0.338 0.000
H66 Suppurative and unspecified otitis media
0.661 0.339 0.000
C48.2 Peritoneum, unspecified
0.661 0.339 0.000
X69 Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
0.661 0.339 0.000
F80-F89 Disorders of psychological development
0.661 0.339 0.000
Y54.3 Benzothiadiazine derivatives
0.661 0.339 0.000
G40 Epilepsy
0.660 0.340 0.000
I69.3 Sequelae of cerebral infarction
0.660 0.340 0.000
G91 Hydrocephalus
0.660 0.340 0.000
Y90 Evidence of alcohol involvement determined by blood alcohol level
0.659 0.341 0.000
Y98 Lifestyle-related condition
0.659 0.341 0.000
Y97 Environmental-pollution-related condition
0.659 0.341 0.000
Y96 Work-related condition
0.659 0.341 0.000
F43.9 Reaction to severe stress, unspecified
0.658 0.342 0.000
F43.8 Other reactions to severe stress
0.658 0.342 0.000
S92 Fracture of foot, except ankle
0.658 0.342 0.000
C18.9 Colon, unspecified
0.658 0.342 0.000
Q60-Q64 Congenital malformations of the urinary system
0.657 0.343 0.000
S05 Injury of eye and orbit
0.657 0.343 0.000
G99.2 Myelopathy in diseases classified elsewhere
0.657 0.343 0.000
C69.3 Choroid
0.656 0.344 0.000
G44 Other headache syndromes
0.656 0.344 0.000
B99 Other and unspecified infectious diseases
0.656 0.344 0.000
C78.5 Secondary malignant neoplasm of large intestine and rectum
0.656 0.344 0.000
G83.9 Paralytic syndrome, unspecified
0.656 0.344 0.000
G83.5 Locked-in syndrome
0.656 0.344 0.000
G83.3 Monoplegia, unspecified
0.656 0.344 0.000
G83.0 Diplegia of upper limbs
0.656 0.344 0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.655 0.345 0.000
X41 Accidental poisoning by and exposure to antiepileptic, sedative-hypnotic, anti-Parkinsonism and psychotropic drugs, not elsewhere classified
0.655 0.345 0.000
C91.0 Acute lymphoblastic leukaemia
0.655 0.345 0.000
C77.8 Lymph nodes of multiple regions
0.654 0.346 0.000
Y91 Evidence of alcohol involvement determined by level of intoxication
0.654 0.346 0.000
A86 Unspecified viral encephalitis
0.654 0.346 0.000
T40.6 Other and unspecified narcotics
0.653 0.347 0.000
F41.8 Other specified anxiety disorders
0.653 0.347 0.000
F41.3 Other mixed anxiety disorders
0.653 0.347 0.000
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.653 0.347 0.000
T50.9 Other and unspecified drugs, medicaments and biological substances
0.652 0.348 0.000
I60 Subarachnoid haemorrhage
0.652 0.348 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.651 0.349 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.650 0.349 0.000
D67 Hereditary factor IX deficiency
0.650 0.350 0.000
D66 Hereditary factor VIII deficiency
0.650 0.350 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.650 0.350 0.000
Y57 Other and unspecified drugs and medicaments
0.650 0.350 0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system
0.649 0.350 0.000
T46.8 Antivaricose drugs, including sclerosing agents
0.649 0.350 0.000
T46.7 Peripheral vasodilators
0.649 0.350 0.000
T46.5 Other antihypertensive drugs, not elsewhere classified
0.649 0.350 0.000
T46.3 Coronary vasodilators, not elsewhere classified
0.649 0.350 0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified
0.649 0.350 0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action
0.649 0.350 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.648 0.351 0.000
G63.2 Diabetic polyneuropathy
0.647 0.353 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.647 0.353 0.000
A40 Streptococcal septicaemia
0.647 0.353 0.000
A48 Other bacterial diseases, not elsewhere classified
0.645 0.355 0.000
A44 Bartonellosis
0.645 0.355 0.000
A43 Nocardiosis
0.645 0.355 0.000
A42 Actinomycosis
0.645 0.355 0.000
A37 Whooping cough
0.645 0.355 0.000
A36 Diphtheria
0.645 0.355 0.000
A32 Listeriosis
0.645 0.355 0.000
A31 Infection due to other mycobacteria
0.645 0.355 0.000
A30 Leprosy [Hansen's disease]
0.645 0.355 0.000
A38 Scarlet fever
0.645 0.355 0.000
A35 Other tetanus
0.645 0.355 0.000
A34 Obstetrical tetanus
0.645 0.355 0.000
A33 Tetanus neonatorum
0.645 0.355 0.000
X47 Accidental poisoning by and exposure to other gases and vapours
0.644 0.356 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.644 0.356 0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis
0.643 0.357 0.000
S35 Injury of blood vessels at abdomen, lower back and pelvis level
0.643 0.357 0.000
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level
0.643 0.357 0.000
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis
0.643 0.357 0.000
S31 Open wound of abdomen, lower back and pelvis
0.643 0.357 0.000
C15 Malignant neoplasm of oesophagus
0.643 0.357 0.000
C91.9 Lymphoid leukaemia, unspecified
0.642 0.358 0.000
C91.8 Mature B-cell leukaemia Burkitt-type
0.642 0.358 0.000
C91.7 Other lymphoid leukaemia
0.642 0.358 0.000
C91.6 Prolymphocytic leukaemia of T-cell type
0.642 0.358 0.000
C91.5 Adult T-cell leukaemia
0.642 0.358 0.000
C91.4 Hairy-cell leukaemia
0.642 0.358 0.000
C91.3 Prolymphocytic leukaemia
0.642 0.358 0.000
C91.2 Subacute lymphocytic leukaemia
0.642 0.358 0.000
D68.4 Acquired coagulation factor deficiency
0.641 0.358 0.000
D68.1 Hereditary factor XI deficiency
0.641 0.358 0.000
D68.0 Von Willebrand's disease
0.641 0.358 0.000
T31 Burns classified according to extent of body surface involved
0.641 0.359 0.000
V80-V89 Other land transport accidents
0.639 0.360 0.000
D55-D59 Haemolytic anaemias
0.639 0.361 0.000
C71.9 Brain, unspecified
0.637 0.363 0.000
I62.1 Nontraumatic extradural haemorrhage
0.637 0.363 0.000
C48.0 Retroperitoneum
0.637 0.363 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.637 0.363 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.636 0.364 0.000
C73 Malignant neoplasm of thyroid gland
0.636 0.364 0.000
C25.0 Head of pancreas
0.635 0.365 0.000
G71 Primary disorders of muscles
0.635 0.365 0.000
U84 Resistance to other antimicrobial drugs
0.634 0.366 0.000
U83 Resistance to other antibiotics
0.634 0.366 0.000
U82 Resistance to betalactam antibiotics
0.634 0.366 0.000
U85 Resistance to antineoplastic drugs
0.634 0.366 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.632 0.368 0.000
T39.4 Antirheumatics, not elsewhere classified
0.632 0.368 0.000
T39.2 Pyrazolone derivatives
0.632 0.368 0.000
Y54.8 Agents affecting uric acid metabolism
0.632 0.368 0.000
C45 Mesothelioma
0.631 0.369 0.000
G00 Bacterial meningitis, not elsewhere classified
0.631 0.369 0.000
C74 Malignant neoplasm of adrenal gland
0.631 0.369 0.000
C71.1 Frontal lobe
0.631 0.369 0.000
C16.0 Cardia
0.630 0.370 0.000
T40.4 Other synthetic narcotics
0.630 0.370 0.000
C26.9 Ill-defined sites within the digestive system
0.629 0.370 0.000
C26.8 Overlapping lesion of digestive system
0.629 0.370 0.000
C26.1 Spleen
0.629 0.370 0.000
Q78 Other osteochondrodysplasias
0.629 0.371 0.000
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx
0.628 0.372 0.000
C13 Malignant neoplasm of hypopharynx
0.628 0.372 0.000
C11 Malignant neoplasm of nasopharynx
0.628 0.372 0.000
C08 Malignant neoplasm of other and unspecified major salivary glands
0.628 0.372 0.000
C06 Malignant neoplasm of other and unspecified parts of mouth
0.628 0.372 0.000
C05 Malignant neoplasm of palate
0.628 0.372 0.000
C03 Malignant neoplasm of gum
0.628 0.372 0.000
C00 Malignant neoplasm of lip
0.628 0.372 0.000
C12 Malignant neoplasm of pyriform sinus
0.628 0.372 0.000
I06 Rheumatic aortic valve diseases
0.628 0.372 0.000
G82.1 Spastic paraplegia
0.628 0.372 0.000
T23 Burn and corrosion of wrist and hand
0.627 0.373 0.000
T20 Burn and corrosion of head and neck
0.626 0.374 0.000
C16.5 Lesser curvature of stomach, unspecified
0.625 0.375 0.000
S06 Intracranial injury
0.625 0.375 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.625 0.375 0.000
S30.2 Contusion of external genital organs
0.624 0.375 0.000
F30 Manic episode
0.624 0.376 0.000
C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs
0.622 0.378 0.000
C38 Malignant neoplasm of heart, mediastinum and pleura
0.622 0.378 0.000
C31 Malignant neoplasm of accessory sinuses
0.622 0.378 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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