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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2857609
log Bayes Factor = 110.666
Chromosome 6   position 31,577,825  (GRCh37) Explore rs2857609 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
I10 Essential (primary) hypertension
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
Chapter IX Diseases of the circulatory system
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
I10-I15 Hypertensive diseases
0.000 0.000 1.000
# Top node
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
I20 Angina pectoris
0.000 0.001 0.999
E14 Unspecified diabetes mellitus
0.000 0.001 0.999
H30-H36 Disorders of choroid and retina
0.000 0.001 0.999
L40-L45 Papulosquamous disorders
0.000 0.001 0.999
L40.5 Arthropathic psoriasis
0.000 0.001 0.999
H36.0 Diabetic retinopathy
0.000 0.001 0.999
H36 Retinal disorders in diseases classified elsewhere
0.000 0.001 0.999
E10.1 With ketoacidosis
0.000 0.001 0.999
G35-G37 Demyelinating diseases of the central nervous system
0.999 0.001 0.000
J45.9 Asthma, unspecified
0.000 0.002 0.998
Chapter VII Diseases of the eye and adnexa
0.000 0.002 0.998
I20.9 Angina pectoris, unspecified
0.000 0.002 0.998
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.002 0.998
I25.1 Atherosclerotic heart disease
0.000 0.003 0.997
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.003 0.997
G37 Other demyelinating diseases of central nervous system
0.997 0.003 0.000
E10.4 With neurological complications
0.000 0.004 0.996
H43-H45 Disorders of vitreous body and globe
0.000 0.005 0.995
H43 Disorders of vitreous body
0.000 0.006 0.994
G37.9 Demyelinating disease of central nervous system, unspecified
0.993 0.007 0.000
L43 Lichen planus
0.000 0.007 0.993
E14.9 Without complications
0.000 0.008 0.992
I22 Subsequent myocardial infarction
0.000 0.009 0.991
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.009 0.991
L43.9 Lichen planus, unspecified
0.000 0.013 0.987
I24 Other acute ischaemic heart diseases
0.000 0.015 0.985
H43.8 Other disorders of vitreous body
0.000 0.016 0.984
E14.3 With ophthalmic complications
0.000 0.017 0.983
M45-M49 Spondylopathies
0.000 0.018 0.982
M45 Ankylosing spondylitis
0.000 0.018 0.982
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.019 0.981
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.020 0.980
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.021 0.979
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.023 0.977
M70-M79 Other soft tissue disorders
0.000 0.023 0.977
E70-E90 Metabolic disorders
0.000 0.025 0.975
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.027 0.973
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.028 0.972
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.034 0.966
E83.1 Disorders of iron metabolism
0.962 0.038 0.000
I20.0 Unstable angina
0.000 0.038 0.962
E16 Other disorders of pancreatic internal secretion
0.000 0.039 0.961
I25.5 Ischaemic cardiomyopathy
0.000 0.039 0.961
K90 Intestinal malabsorption
0.000 0.041 0.959
H34 Retinal vascular occlusions
0.000 0.042 0.958
H43.3 Other vitreous opacities
0.000 0.049 0.951
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.049 0.951
E16.2 Hypoglycaemia, unspecified
0.000 0.050 0.950
K90-K93 Other diseases of the digestive system
0.000 0.053 0.947
Chapter XI Diseases of the digestive system
0.000 0.053 0.947
I12 Hypertensive renal disease
0.000 0.064 0.936
K70-K77 Diseases of liver
0.000 0.067 0.933
H35 Other retinal disorders
0.000 0.068 0.932
M75 Shoulder lesions
0.000 0.070 0.930
M05 Seropositive rheumatoid arthritis
0.000 0.071 0.929
K74 Fibrosis and cirrhosis of liver
0.000 0.075 0.925
E07 Other disorders of thyroid
0.000 0.078 0.922
E10.5 With peripheral circulatory complications
0.000 0.078 0.922
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.084 0.916
H35.8 Other specified retinal disorders
0.000 0.089 0.911
K74.3 Primary biliary cirrhosis
0.000 0.090 0.910
H34.8 Other retinal vascular occlusions
0.000 0.091 0.909
M07 Psoriatic and enteropathic arthropathies
0.000 0.091 0.909
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.092 0.908
Chapter VIII Diseases of the ear and mastoid process
0.000 0.094 0.906
I12.9 Hypertensive renal disease without renal failure
0.000 0.097 0.903
M75.0 Adhesive capsulitis of shoulder
0.000 0.100 0.900
M77 Other enthesopathies
0.000 0.104 0.896
G37.8 Other specified demyelinating diseases of central nervous system
0.894 0.106 0.000
E13 Other specified diabetes mellitus
0.000 0.106 0.894
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.106 0.894
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.107 0.893
H60-H62 Diseases of external ear
0.000 0.116 0.884
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.117 0.883
I15 Secondary hypertension
0.000 0.118 0.882
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.122 0.878
E10.2 With renal complications
0.000 0.125 0.875
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.129 0.870
E07.9 Disorder of thyroid, unspecified
0.000 0.133 0.867
E10.8 With unspecified complications
0.000 0.136 0.864
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.139 0.861
M77.1 Lateral epicondylitis
0.000 0.143 0.857
Chapter VI Diseases of the nervous system
0.855 0.144 0.001
E11.3 With ophthalmic complications
0.000 0.144 0.855
M06.3 Rheumatoid nodule
0.000 0.149 0.851
H60 Otitis externa
0.000 0.152 0.848
M07.3 Other psoriatic arthropathies
0.000 0.156 0.844
G20-G26 Extrapyramidal and movement disorders
0.842 0.157 0.000
K72 Hepatic failure, not elsewhere classified
0.000 0.159 0.841
M70 Soft tissue disorders related to use, overuse and pressure
0.000 0.160 0.840
K55-K64 Other diseases of intestines
0.000 0.161 0.839
G20 Parkinson's disease
0.835 0.165 0.000
E78.8 Other disorders of lipoprotein metabolism
0.000 0.167 0.833
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.168 0.832
K60 Fissure and fistula of anal and rectal regions
0.000 0.169 0.831
M77.12 Lateral epicondylitis (Upper arm)
0.000 0.170 0.830
E11.2 With renal complications
0.000 0.171 0.829
K60.2 Anal fissure, unspecified
0.000 0.178 0.822
E13.9 Without complications
0.000 0.181 0.819
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.182 0.818
M75.3 Calcific tendinitis of shoulder
0.000 0.182 0.818
L43.8 Other lichen planus
0.000 0.184 0.816
K74.5 Biliary cirrhosis, unspecified
0.000 0.185 0.815
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.189 0.811
L40.8 Other psoriasis
0.000 0.195 0.805
H65-H75 Diseases of middle ear and mastoid
0.000 0.197 0.803
I25.2 Old myocardial infarction
0.000 0.201 0.799
E11.0 With coma
0.000 0.202 0.798
I15.1 Hypertension secondary to other renal disorders
0.000 0.202 0.798
E05.9 Thyrotoxicosis, unspecified
0.000 0.202 0.798
M75.2 Bicipital tendinitis
0.000 0.208 0.792
H43.9 Disorder of vitreous body, unspecified
0.000 0.212 0.788
H35.4 Peripheral retinal degeneration
0.000 0.212 0.788
I25.3 Aneurysm of heart
0.000 0.214 0.786
M65-M68 Disorders of synovium and tendon
0.000 0.217 0.783
K55 Vascular disorders of intestine
0.000 0.222 0.778
H43.1 Vitreous haemorrhage
0.000 0.224 0.776
M70.4 Prepatellar bursitis
0.000 0.225 0.775
H61 Other disorders of external ear
0.000 0.226 0.774
E78.2 Mixed hyperlipidaemia
0.000 0.226 0.774
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.227 0.773
H34.2 Other retinal artery occlusions
0.000 0.228 0.772
E40-E46 Malnutrition
0.000 0.228 0.772
H35.2 Other proliferative retinopathy
0.000 0.229 0.771
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.236 0.764
H71 Cholesteatoma of middle ear
0.000 0.241 0.759
K58 Irritable bowel syndrome
0.000 0.243 0.757
E06 Thyroiditis
0.000 0.244 0.756
I47 Paroxysmal tachycardia
0.000 0.244 0.756
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.245 0.755
K73 Chronic hepatitis, not elsewhere classified
0.000 0.246 0.754
H66 Suppurative and unspecified otitis media
0.000 0.248 0.752
M75.4 Impingement syndrome of shoulder
0.000 0.248 0.752
E11.1 With ketoacidosis
0.000 0.249 0.751
I30-I52 Other forms of heart disease
0.000 0.250 0.750
K74.6 Other and unspecified cirrhosis of liver
0.000 0.251 0.749
I20.1 Angina pectoris with documented spasm
0.000 0.251 0.749
K60.0 Acute anal fissure
0.000 0.251 0.749
E74 Other disorders of carbohydrate metabolism
0.000 0.254 0.745
I21 Acute myocardial infarction
0.000 0.254 0.746
K72.9 Hepatic failure, unspecified
0.000 0.256 0.744
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.257 0.743
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.258 0.742
I23 Certain current complications following acute myocardial infarction
0.000 0.260 0.740
I47.1 Supraventricular tachycardia
0.000 0.260 0.740
H43.2 Crystalline deposits in vitreous body
0.000 0.260 0.740
H60.9 Otitis externa, unspecified
0.000 0.261 0.739
K58.0 Irritable bowel syndrome with diarrhoea
0.000 0.262 0.738
H66.3 Other chronic suppurative otitis media
0.000 0.262 0.738
E11.5 With peripheral circulatory complications
0.000 0.263 0.737
M06.34 Rheumatoid nodule (Hand)
0.000 0.265 0.735
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.001 0.266 0.733
L40.0 Psoriasis vulgaris
0.000 0.270 0.730
M70.46 Prepatellar bursitis-Lower Leg
0.000 0.271 0.729
H35.6 Retinal haemorrhage
0.000 0.273 0.727
E14.1 With ketoacidosis
0.000 0.273 0.726
K55.2 Angiodysplasia of colon
0.000 0.274 0.726
M14 Arthropathies in other diseases classified elsewhere
0.000 0.279 0.721
H34.1 Central retinal artery occlusion
0.000 0.279 0.721
M79 Other soft tissue disorders, not elsewhere classified
0.000 0.280 0.720
H60.3 Other infective otitis externa
0.000 0.281 0.719
H61.1 Non-infective disorders of pinna
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E10.6 With other specified complications
0.000 0.283 0.717
E10.0 With coma
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
I13 Hypertensive heart and renal disease
0.000 0.283 0.717
I00-I02 Acute rheumatic fever
0.000 0.283 0.717
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.284 0.716
E14.7 With multiple complications
0.000 0.284 0.716
E14.5 With peripheral circulatory complications
0.000 0.284 0.716
E14.2 Withrenal complications
0.000 0.284 0.716
E14.0 With coma
0.000 0.284 0.716
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.284 0.716
H30 Chorioretinal inflammation
0.000 0.284 0.716
L44 Other papulosquamous disorders
0.000 0.284 0.716
L41 Parapsoriasis
0.000 0.284 0.716
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.284 0.716
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.284 0.716
G36 Other acute disseminated demyelination
0.716 0.284 0.000
I47.2 Ventricular tachycardia
0.000 0.285 0.715
G30-G32 Other degenerative diseases of the nervous system
0.714 0.285 0.000
G37.5 Concentric sclerosis [Balo]
0.715 0.285 0.000
G37.4 Subacute necrotising myelitis
0.715 0.285 0.000
G37.2 Central pontine myelinolysis
0.715 0.285 0.000
G37.1 Central demyelination of corpus callosum
0.715 0.285 0.000
G37.0 Diffuse sclerosis
0.715 0.285 0.000
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.287 0.713
H43.0 Vitreous prolapse
0.000 0.287 0.713
L43.3 Subacute (active) lichen planus
0.000 0.288 0.712
L43.2 Lichenoid drug reaction
0.000 0.288 0.712
L43.1 Bullous lichen planus
0.000 0.288 0.712
L43.0 Hypertrophic lichen planus
0.000 0.288 0.712
M65 Synovitis and tenosynovitis
0.000 0.289 0.711
I51 Complications and ill-defined descriptions of heart disease
0.000 0.290 0.710
E78.4 Other hyperlipidaemia
0.000 0.290 0.710
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.709 0.291 0.000
H31 Other disorders of choroid
0.000 0.291 0.709
L42 Pityriasis rosea
0.000 0.292 0.708
M71 Other bursopathies
0.000 0.292 0.708
G40-G47 Episodic and paroxysmal disorders
0.708 0.292 0.000
E03.8 Other specified hypothyroidism
0.000 0.294 0.706
I51.8 Other ill-defined heart diseases
0.000 0.295 0.705
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.296 0.704
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.296 0.704
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.296 0.704
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.296 0.704
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.296 0.704
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.296 0.704
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.296 0.704
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.296 0.704
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.296 0.704
E78.3 Hyperchylomicronaemia
0.000 0.296 0.704
E15 Nondiabetic hypoglycaemic coma
0.000 0.299 0.701
M73 Soft tissue disorders in diseases classified elsewhere
0.000 0.299 0.700
E78.6 Lipoprotein deficiency
0.000 0.300 0.700
E77 Disorders of glycoprotein metabolism
0.000 0.301 0.699
E76 Disorders of glycosaminoglycan metabolism
0.000 0.301 0.699
E72 Other disorders of amino-acid metabolism
0.000 0.301 0.699
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.301 0.699
E70 Disorders of aromatic amino-acid metabolism
0.000 0.301 0.699
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.301 0.699
K60.5 Anorectal fistula
0.000 0.301 0.699
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.302 0.698
E83 Disorders of mineral metabolism
0.603 0.303 0.094
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.304 0.696
M77.5 Other enthesopathy of foot
0.000 0.304 0.696
E79 Disorders of purine and pyrimidine metabolism
0.000 0.308 0.692
I35 Nonrheumatic aortic valve disorders
0.000 0.308 0.692
I35.0 Aortic (valve) stenosis
0.000 0.309 0.691
M49 Spondylopathies in diseases classified elsewhere
0.000 0.311 0.689
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.311 0.689
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.311 0.689
E16.4 Abnormal secretion of gastrin
0.000 0.311 0.689
E16.3 Increased secretion of glucagon
0.000 0.311 0.689
E16.1 Other hypoglycaemia
0.000 0.311 0.689
K90.3 Pancreatic steatorrhoea
0.000 0.312 0.687
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.312 0.687
K90.1 Tropical sprue
0.000 0.312 0.687
H34.0 Transient retinal artery occlusion
0.000 0.313 0.687
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.314 0.686
M06.4 Inflammatory polyarthropathy
0.000 0.315 0.685
G25 Other extrapyramidal and movement disorders
0.684 0.316 0.000
H35.5 Hereditary retinal dystrophy
0.000 0.317 0.683
H34.9 Retinal vascular occlusion, unspecified
0.000 0.317 0.683
M06.0 Seronegative rheumatoid arthritis
0.000 0.317 0.683
E78.1 Pure hyperglyceridaemia
0.000 0.317 0.682
E14.6 With other specified complications
0.000 0.319 0.681
H60.1 Cellulitis of external ear
0.000 0.319 0.681
E11.8 With unspecified complications
0.000 0.320 0.680
K72.0 Acute and subacute hepatic failure
0.000 0.320 0.680
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.321 0.679
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.321 0.679
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.324 0.675
E11.6 With other specified complications
0.000 0.326 0.674
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.327 0.673
M79.7 Fibromyalgia
0.000 0.327 0.673
M65.4 Radial styloid tenosynovitis [de Quervain]
0.000 0.328 0.672
M79.6 Pain in limb
0.000 0.330 0.670
K77 Liver disorders in diseases classified elsewhere
0.000 0.331 0.669
K71 Toxic liver disease
0.000 0.331 0.669
H35.1 Retinopathy of prematurity
0.000 0.332 0.668
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.332 0.668
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.333 0.667
M75.8 Other shoulder lesions
0.000 0.333 0.667
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.333 0.667
M05.8 Other seropositive rheumatoid arthritis
0.000 0.334 0.666
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.334 0.666
M05.2 Rheumatoid vasculitis
0.000 0.334 0.666
M05.1 Rheumatoid lung disease
0.000 0.334 0.666
M05.0 Felty's syndrome
0.000 0.334 0.666
H60.8 Other otitis externa
0.000 0.336 0.664
H61.3 Acquired stenosis of external ear canal
0.000 0.336 0.664
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.336 0.663
K74.4 Secondary biliary cirrhosis
0.000 0.337 0.663
K74.2 Hepatic fibrosis with hepatic sclerosis
0.000 0.337 0.663
K74.1 Hepatic sclerosis
0.000 0.337 0.663
M79.65 Pain in limb (Pelvic region and thigh)
0.000 0.339 0.661
E07.1 Dyshormogenetic goitre
0.000 0.339 0.661
E07.0 Hypersecretion of calcitonin
0.000 0.339 0.661
E07.8 Other specified disorders of thyroid
0.000 0.339 0.661
K90.8 Other intestinal malabsorption
0.000 0.339 0.660
K55.8 Other vascular disorders of intestine
0.000 0.343 0.657
M75.9 Shoulder lesion, unspecified
0.000 0.344 0.656
M07.6 Other enteropathic arthropathies
0.000 0.348 0.652
M07.5 Arthropathy in ulcerative colitis
0.000 0.348 0.652
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.348 0.652
M07.2 Psoriatic spondylitis
0.000 0.348 0.652
M07.1 Arthritis mutilans
0.000 0.348 0.652
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.348 0.652
I47.9 Paroxysmal tachycardia, unspecified
0.000 0.349 0.651
L10-L14 Bullous disorders
0.000 0.349 0.651
H60.5 Acute otitis externa, non-infective
0.000 0.349 0.651
E05.5 Thyroid crisis or storm
0.000 0.349 0.651
E05.4 Thyrotoxicosis factitia
0.000 0.349 0.651
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.349 0.651
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.349 0.651
H35.7 Separation of retinal layers
0.000 0.350 0.650
I05-I09 Chronic rheumatic heart diseases
0.000 0.351 0.649
M77.0 Medial epicondylitis
0.000 0.352 0.648
M11 Other crystal arthropathies
0.000 0.353 0.647
I11 Hypertensive heart disease
0.000 0.353 0.646
E06.3 Autoimmune thyroiditis
0.000 0.354 0.646
M12 Other specific arthropathies
0.000 0.355 0.645
I25.4 Coronary artery aneurysm
0.000 0.356 0.644
M77.8 Other enthesopathies, not elsewhere classified
0.000 0.357 0.643
M77.3 Calcaneal spur
0.000 0.357 0.643
M77.2 Periarthritis of wrist
0.000 0.357 0.643
K60.4 Rectal fistula
0.000 0.358 0.642
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.000 0.358 0.642
E13.8 With unspecified complications
0.000 0.359 0.641
E13.7 With multiple complications
0.000 0.359 0.641
E13.6 With other specified complications
0.000 0.359 0.641
E13.5 With peripheral circulatory complications
0.000 0.359 0.641
E13.4 With neurological complications
0.000 0.359 0.641
E13.3 With ophthalmic complications
0.000 0.359 0.641
E13.2 With renal complications
0.000 0.359 0.641
E13.1 With ketoacidosis
0.000 0.359 0.641
E13.0 With coma
0.000 0.359 0.641
E84 Cystic fibrosis
0.001 0.362 0.638
M79.79 Fibromyalgia (Site unspecified)
0.000 0.363 0.637
K75 Other inflammatory liver diseases
0.000 0.365 0.635
H62 Disorders of external ear in diseases classified elsewhere
0.000 0.366 0.634
E14.4 With neurological complications
0.000 0.366 0.633
M46 Other inflammatory spondylopathies
0.000 0.367 0.633
I15.9 Seconday hypertension, unspecified
0.000 0.367 0.633
I15.8 Other secondary hypertension
0.000 0.367 0.633
I15.2 Hypertension secondary to endocrine disorders
0.000 0.367 0.633
I15.0 Renovascular hypertension
0.000 0.367 0.633
L40.3 Pustulosis palmaris et plantaris
0.000 0.368 0.632
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.371 0.629
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.371 0.629
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.371 0.629
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.371 0.629
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.371 0.629
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.371 0.629
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.371 0.629
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.371 0.629
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.372 0.628
G00-G09 Inflammatory diseases of the central nervous system
0.628 0.372 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.376 0.624
G46 Vascular syndromes of brain in cerebrovascular diseases
0.619 0.381 0.000
K73.2 Chronic active hepatitis, not elsewhere classified
0.000 0.382 0.618
H74 Other disorders of middle ear and mastoid
0.000 0.383 0.617
H60.4 Cholesteatoma of external ear
0.000 0.384 0.616
M77.19 Lateral epicondylitis (Site unspecified)
0.000 0.385 0.615
M77.18 Lateral epicondylitis-Other
0.000 0.385 0.615
M77.17 Lateral epicondylitis-Ankle/Foot
0.000 0.385 0.615
M77.16 Lateral epicondylitis (Lower leg)
0.000 0.385 0.615
M77.15 Lateral epicondylitis (Pelvic region and thigh)
0.000 0.385 0.615
M77.14 Lateral epicondylitis-Hand
0.000 0.385 0.615
M77.13 Lateral epicondylitis-Forearm
0.000 0.385 0.615
M77.11 Lateral epicondylitis-Shldr region
0.000 0.385 0.615
M77.10 Lateral epicondylitis (Multiple sites)
0.000 0.385 0.615
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.387 0.613
M91-M94 Chondropathies
0.000 0.387 0.612
I47.0 Reentry ventricular arrhythmia
0.000 0.389 0.611
M77.4 Metatarsalgia
0.000 0.390 0.610
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.390 0.610
M06.38 Rheumatoid nodule (Other)
0.000 0.390 0.610
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.390 0.610
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.390 0.610
M06.33 Rheumatoid nodule (Forearm)
0.000 0.390 0.610
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.390 0.610
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.390 0.610
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.390 0.610
K90.9 Intestinal malabsorption, unspecified
0.000 0.391 0.609
H60.2 Malignant otitis externa
0.000 0.392 0.608
E46 Unspecified protein-energy malnutrition
0.000 0.392 0.608
M07.38 Other psoriatic arthropathies (Other)
0.000 0.395 0.605
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.395 0.605
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.395 0.605
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.395 0.605
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.395 0.605
M70.2 Olecranon bursitis
0.000 0.395 0.605
M96.0 Pseudarthrosis after fusion or arthrodesis
0.000 0.395 0.605
G23 Other degenerative diseases of basal ganglia
0.604 0.396 0.000
G21 Secondary Parkinsonism
0.604 0.396 0.000
G26 Extrapyramidal and movement disorders in diseases classified elsewhere
0.604 0.396 0.000
G22 Parkinsonism in diseases classified elsewhere
0.604 0.396 0.000
K72.1 Chronic hepatic failure
0.000 0.397 0.603
M70.9 Unspecified soft tissue disorder related to use, overuse and pressure
0.000 0.398 0.602
M70.8 Other soft tissue disorders related to use, overuse and pressure
0.000 0.398 0.602
M70.1 Bursitis of hand
0.000 0.398 0.602
M70.0 Chronic crepitant synovitis of hand and wrist
0.000 0.398 0.602
K64 Haemorrhoids and perianal venous thrombosis
0.000 0.399 0.601
H60.0 Abscess of external ear
0.000 0.399 0.601
G41 Status epilepticus
0.600 0.400 0.000
M65.43 Radial styloid tenosynovitis [de Quervain] (Forearm)
0.000 0.401 0.599
I24.1 Dressler's syndrome
0.000 0.402 0.598
M65.44 Radial styloid tenosynovitis [de Quervain] (Hand)
0.000 0.403 0.597
G30 Alzheimer's disease
0.595 0.405 0.000
M70.5 Other bursitis of knee
0.000 0.410 0.590
M00-M03 Infectious arthropathies
0.000 0.411 0.588
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.412 0.588
M70.7 Other bursitis of hip
0.000 0.412 0.588
E05.8 Other thyrotoxicosis
0.000 0.413 0.587
G40 Epilepsy
0.586 0.414 0.000
I22.8 Subsequent myocardial infarction of other sites
0.000 0.414 0.586
G44 Other headache syndromes
0.584 0.416 0.000
K55.1 Chronic vascular disorders of intestine
0.000 0.416 0.584
H66.1 Chronic tubotympanic suppurative otitis media
0.000 0.417 0.582
K73.9 Chronic hepatitis, unspecified
0.000 0.418 0.582
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.419 0.581
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.000 0.424 0.576
H68 Eustachian salpingitis and obstruction
0.000 0.424 0.576
H67 Otitis media in diseases classified elsewhere
0.000 0.424 0.576
E88 Other metabolic disorders
0.000 0.425 0.574
H66.4 Suppurative otitis media, unspecified
0.000 0.427 0.573
M71.2 Synovial cyst of popliteal space [Baker]
0.000 0.428 0.571
K75.4 Autoimmune hepatitis
0.000 0.429 0.571
I12.0 Hypertensive renal disease with renal failure
0.000 0.430 0.570
E73 Lactose intolerance
0.001 0.431 0.569
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.566 0.433 0.001
K74.0 Hepatic fibrosis
0.000 0.434 0.566
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.001 0.434 0.565
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.435 0.565
I21.4 Acute subendocardial myocardial infarction
0.000 0.436 0.564
M70.3 Other bursitis of elbow
0.000 0.436 0.564
E85 Amyloidosis
0.001 0.437 0.563
M65.8 Other synovitis and tenosynovitis
0.000 0.437 0.563
E83.3 Disorders of phosphorus metabolism
0.532 0.438 0.029
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.000 0.439 0.561
H61.8 Other specified disorders of external ear
0.000 0.439 0.561
H31.0 Chorioretinal scars
0.000 0.440 0.560
M79.64 Pain in limb (Hand)
0.000 0.443 0.557
M70.6 Trochanteric bursitis
0.000 0.443 0.556
M70.49 Prepatellar bursitis-Site unspec
0.000 0.444 0.556
M70.48 Prepatellar bursitis-Other
0.000 0.444 0.556
M70.47 Prepatellar bursitis-Ankle/Foot
0.000 0.444 0.556
M70.45 Prepatellar bursitis-Pelvic/Thigh
0.000 0.444 0.556
M70.44 Prepatellar bursitis-Hand
0.000 0.444 0.556
M70.43 Prepatellar bursitis-Forearm
0.000 0.444 0.556
M70.42 Prepatellar bursitis-Upper arm
0.000 0.444 0.556
M70.41 Prepatellar bursitis-Shldr region
0.000 0.444 0.556
M70.40 Prepatellar bursitis-Mult sites
0.000 0.444 0.556
M79.2 Neuralgia and neuritis, unspecified
0.000 0.445 0.555
I23.8 Other current complications following acute myocardial infarction
0.000 0.446 0.554
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.447 0.553
E45 Retarded development following protein-energy malnutrition
0.000 0.447 0.553
E43 Unspecified severe protein-energy malnutrition
0.000 0.447 0.553
E42 Marasmic kwashiorkor
0.000 0.447 0.553
E41 Nutritional marasmus
0.000 0.447 0.553
E40 Kwashiorkor
0.000 0.447 0.553
M77.57 Other enthesopathy of foot-Ankle/Foot
0.000 0.448 0.552
M79.63 Pain in limb (Forearm)
0.000 0.448 0.552
M76 Enthesopathies of lower limb, excluding foot
0.000 0.449 0.550
I51.0 Cardiac septal defect, acquired
0.000 0.451 0.549
G80-G83 Cerebral palsy and other paralytic syndromes
0.549 0.451 0.000
E89.3 Postprocedural hypopituitarism
0.000 0.456 0.544
E06.5 Other chronic thyroiditis
0.000 0.458 0.542
E06.4 Drug-induced thyroiditis
0.000 0.458 0.542
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.458 0.542
E06.1 Subacute thyroiditis
0.000 0.458 0.542
E06.0 Acute thyroiditis
0.000 0.458 0.542
M79.67 Pain in limb (Ankle and foot)
0.000 0.459 0.541
K73.1 Chronic lobular hepatitis, not elsewhere classified
0.000 0.459 0.541

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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