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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2857709
log Bayes Factor = 104.056
Chromosome 6   position 31,532,814  (GRCh37) Explore rs2857709 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
I10 Essential (primary) hypertension
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
I10-I15 Hypertensive diseases
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
Chapter IX Diseases of the circulatory system
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
I20 Angina pectoris
0.000 0.000 1.000
E14.9 Without complications
0.000 0.000 1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.000 1.000
I20.9 Angina pectoris, unspecified
0.000 0.001 0.999
J45.9 Asthma, unspecified
0.000 0.001 0.999
L40.5 Arthropathic psoriasis
0.000 0.002 0.998
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.002 0.998
M06 Other rheumatoid arthritis
0.000 0.003 0.997
L40-L45 Papulosquamous disorders
0.000 0.003 0.997
E70-E90 Metabolic disorders
0.000 0.004 0.996
E10.1 With ketoacidosis
0.000 0.004 0.996
I22 Subsequent myocardial infarction
0.000 0.005 0.995
M05-M14 Inflammatory polyarthropathies
0.000 0.006 0.994
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.006 0.994
E14.3 With ophthalmic complications
0.000 0.006 0.994
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.007 0.993
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.007 0.993
# Top node
0.000 0.008 0.992
M45 Ankylosing spondylitis
0.000 0.008 0.992
G35-G37 Demyelinating diseases of the central nervous system
0.990 0.010 0.000
M45-M49 Spondylopathies
0.000 0.010 0.990
I25.2 Old myocardial infarction
0.000 0.011 0.989
M70-M79 Other soft tissue disorders
0.000 0.012 0.988
I25.5 Ischaemic cardiomyopathy
0.000 0.014 0.986
G37 Other demyelinating diseases of central nervous system
0.986 0.014 0.000
M75 Shoulder lesions
0.000 0.017 0.983
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.018 0.982
E10.4 With neurological complications
0.000 0.019 0.981
L43 Lichen planus
0.000 0.023 0.977
G37.9 Demyelinating disease of central nervous system, unspecified
0.976 0.024 0.000
M75.0 Adhesive capsulitis of shoulder
0.000 0.024 0.976
I21 Acute myocardial infarction
0.000 0.028 0.972
M75.4 Impingement syndrome of shoulder
0.000 0.033 0.967
I20.0 Unstable angina
0.000 0.036 0.964
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.036 0.964
I12 Hypertensive renal disease
0.000 0.044 0.956
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.044 0.956
L43.9 Lichen planus, unspecified
0.000 0.046 0.954
I24 Other acute ischaemic heart diseases
0.000 0.053 0.947
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.053 0.947
H30-H36 Disorders of choroid and retina
0.000 0.055 0.945
Chapter VII Diseases of the eye and adnexa
0.000 0.056 0.944
H36 Retinal disorders in diseases classified elsewhere
0.000 0.057 0.943
H36.0 Diabetic retinopathy
0.000 0.058 0.942
E78.2 Mixed hyperlipidaemia
0.000 0.061 0.939
I30-I52 Other forms of heart disease
0.000 0.065 0.935
E78.8 Other disorders of lipoprotein metabolism
0.000 0.078 0.922
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.087 0.913
H35 Other retinal disorders
0.000 0.089 0.911
I51 Complications and ill-defined descriptions of heart disease
0.000 0.089 0.911
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.090 0.910
I15 Secondary hypertension
0.000 0.091 0.909
H43-H45 Disorders of vitreous body and globe
0.000 0.093 0.907
I51.8 Other ill-defined heart diseases
0.000 0.098 0.902
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.099 0.901
H35.8 Other specified retinal disorders
0.000 0.100 0.900
I12.9 Hypertensive renal disease without renal failure
0.000 0.101 0.899
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.101 0.899
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.104 0.896
I47 Paroxysmal tachycardia
0.000 0.105 0.895
E13 Other specified diabetes mellitus
0.000 0.106 0.894
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.106 0.894
H43 Disorders of vitreous body
0.000 0.109 0.891
I21.9 Acute myocardial infarction, unspecified
0.000 0.111 0.889
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.115 0.885
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.124 0.876
G37.8 Other specified demyelinating diseases of central nervous system
0.875 0.125 0.000
E10.2 With renal complications
0.000 0.126 0.874
I21.4 Acute subendocardial myocardial infarction
0.000 0.128 0.872
E10.5 With peripheral circulatory complications
0.000 0.129 0.871
E07 Other disorders of thyroid
0.000 0.130 0.870
E05.9 Thyrotoxicosis, unspecified
0.000 0.134 0.866
I35 Nonrheumatic aortic valve disorders
0.000 0.134 0.866
M05 Seropositive rheumatoid arthritis
0.000 0.135 0.865
K90 Intestinal malabsorption
0.000 0.135 0.865
I35.0 Aortic (valve) stenosis
0.000 0.151 0.849
E11.0 With coma
0.000 0.155 0.845
M06.3 Rheumatoid nodule
0.000 0.160 0.840
M07 Psoriatic and enteropathic arthropathies
0.000 0.161 0.839
I15.1 Hypertension secondary to other renal disorders
0.000 0.168 0.832
E16 Other disorders of pancreatic internal secretion
0.000 0.169 0.831
H25-H28 Disorders of lens
0.000 0.170 0.830
M70 Soft tissue disorders related to use, overuse and pressure
0.000 0.171 0.829
E74 Other disorders of carbohydrate metabolism
0.000 0.171 0.829
H43.3 Other vitreous opacities
0.000 0.176 0.824
H43.8 Other disorders of vitreous body
0.000 0.180 0.820
M79 Other soft tissue disorders, not elsewhere classified
0.000 0.180 0.820
E13.9 Without complications
0.000 0.181 0.819
E11.1 With ketoacidosis
0.000 0.184 0.816
L40.8 Other psoriasis
0.000 0.184 0.816
E10.6 With other specified complications
0.000 0.186 0.814
L43.8 Other lichen planus
0.000 0.188 0.812
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.188 0.812
I47.9 Paroxysmal tachycardia, unspecified
0.000 0.192 0.808
I12.0 Hypertensive renal disease with renal failure
0.000 0.193 0.807
E78.5 Hyperlipidaemia, unspecified
0.000 0.193 0.807
I47.2 Ventricular tachycardia
0.000 0.193 0.807
E83 Disorders of mineral metabolism
0.749 0.197 0.054
I25.3 Aneurysm of heart
0.000 0.203 0.797
I44 Atrioventricular and left bundle-branch block
0.000 0.208 0.792
M79.6 Pain in limb
0.000 0.211 0.789
E11.5 With peripheral circulatory complications
0.000 0.212 0.788
E10.0 With coma
0.000 0.212 0.788
E40-E46 Malnutrition
0.000 0.216 0.783
E16.2 Hypoglycaemia, unspecified
0.000 0.222 0.778
E07.9 Disorder of thyroid, unspecified
0.000 0.225 0.775
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.228 0.772
I23 Certain current complications following acute myocardial infarction
0.000 0.228 0.772
K90-K93 Other diseases of the digestive system
0.000 0.230 0.770
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.237 0.763
Chapter XI Diseases of the digestive system
0.000 0.237 0.763
E11.3 With ophthalmic complications
0.000 0.241 0.759
H34 Retinal vascular occlusions
0.000 0.243 0.757
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.757 0.243 0.000
H43.9 Disorder of vitreous body, unspecified
0.000 0.246 0.754
M49 Spondylopathies in diseases classified elsewhere
0.000 0.250 0.750
M79.65 Pain in limb (Pelvic region and thigh)
0.000 0.251 0.749
E85 Amyloidosis
0.000 0.252 0.748
I46 Cardiac arrest
0.000 0.253 0.747
H27 Other disorders of lens
0.000 0.254 0.746
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.255 0.745
M75.3 Calcific tendinitis of shoulder
0.000 0.256 0.744
I51.9 Heart disease, unspecified
0.000 0.258 0.742
M06.4 Inflammatory polyarthropathy
0.000 0.259 0.741
K70-K77 Diseases of liver
0.000 0.261 0.739
L40.0 Psoriasis vulgaris
0.000 0.268 0.732
I51.0 Cardiac septal defect, acquired
0.000 0.269 0.731
E78.1 Pure hyperglyceridaemia
0.000 0.270 0.730
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.270 0.730
H25 Senile cataract
0.000 0.270 0.730
I45 Other conduction disorders
0.000 0.271 0.729
M07.3 Other psoriatic arthropathies
0.000 0.271 0.728
I24.8 Other forms of acute ischaemic heart disease
0.000 0.274 0.726
I22.8 Subsequent myocardial infarction of other sites
0.000 0.276 0.723
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.277 0.722
K74 Fibrosis and cirrhosis of liver
0.000 0.278 0.722
L42 Pityriasis rosea
0.000 0.279 0.721
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.280 0.720
M75.2 Bicipital tendinitis
0.000 0.280 0.720
M11 Other crystal arthropathies
0.000 0.282 0.718
I49 Other cardiac arrhythmias
0.000 0.282 0.718
M71 Other bursopathies
0.000 0.282 0.718
E11.2 With renal complications
0.000 0.282 0.718
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
E10.8 With unspecified complications
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.5 With peripheral circulatory complications
0.000 0.283 0.717
E14.4 With neurological complications
0.000 0.283 0.717
E14.2 Withrenal complications
0.000 0.283 0.717
E14.1 With ketoacidosis
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
I13 Hypertensive heart and renal disease
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
I00-I02 Acute rheumatic fever
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E78.6 Lipoprotein deficiency
0.000 0.283 0.717
E78.3 Hyperchylomicronaemia
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.285 0.715
M06.2 Rheumatoid bursitis
0.000 0.285 0.715
M06.1 Adult-onset Still's disease
0.000 0.285 0.715
L44 Other papulosquamous disorders
0.000 0.285 0.715
L41 Parapsoriasis
0.000 0.285 0.715
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.285 0.715
E79 Disorders of purine and pyrimidine metabolism
0.000 0.286 0.714
E77 Disorders of glycoprotein metabolism
0.000 0.286 0.714
E76 Disorders of glycosaminoglycan metabolism
0.000 0.286 0.714
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.286 0.714
E72 Other disorders of amino-acid metabolism
0.000 0.286 0.714
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.286 0.714
E70 Disorders of aromatic amino-acid metabolism
0.000 0.286 0.714
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.286 0.714
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.287 0.713
M08 Juvenile arthritis
0.000 0.287 0.713
M06.34 Rheumatoid nodule (Hand)
0.000 0.288 0.712
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.289 0.711
E83.3 Disorders of phosphorus metabolism
0.698 0.289 0.013
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.289 0.711
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.289 0.711
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.289 0.711
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.289 0.711
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.289 0.711
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.289 0.711
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.289 0.711
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.289 0.711
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.290 0.710
G36 Other acute disseminated demyelination
0.710 0.290 0.000
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.291 0.709
M73 Soft tissue disorders in diseases classified elsewhere
0.000 0.292 0.708
M77 Other enthesopathies
0.000 0.292 0.708
H35.4 Peripheral retinal degeneration
0.000 0.292 0.708
M91-M94 Chondropathies
0.000 0.293 0.707
G37.5 Concentric sclerosis [Balo]
0.707 0.293 0.000
G37.4 Subacute necrotising myelitis
0.707 0.293 0.000
G37.2 Central pontine myelinolysis
0.707 0.293 0.000
G37.1 Central demyelination of corpus callosum
0.707 0.293 0.000
G37.0 Diffuse sclerosis
0.707 0.293 0.000
M75.8 Other shoulder lesions
0.000 0.295 0.705
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.295 0.705
E14.6 With other specified complications
0.000 0.296 0.703
M79.1 Myalgia
0.000 0.298 0.702
L43.3 Subacute (active) lichen planus
0.000 0.299 0.701
L43.2 Lichenoid drug reaction
0.000 0.299 0.701
L43.1 Bullous lichen planus
0.000 0.299 0.701
L43.0 Hypertrophic lichen planus
0.000 0.299 0.701
H30 Chorioretinal inflammation
0.000 0.301 0.699
I44.0 Atrioventricular block, first degree
0.000 0.303 0.697
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.303 0.697
K74.3 Primary biliary cirrhosis
0.000 0.304 0.696
M70.4 Prepatellar bursitis
0.000 0.305 0.695
E78.4 Other hyperlipidaemia
0.000 0.305 0.694
H35.2 Other proliferative retinopathy
0.000 0.309 0.691
I15.9 Seconday hypertension, unspecified
0.000 0.309 0.691
H35.5 Hereditary retinal dystrophy
0.000 0.309 0.691
I51.6 Cardiovascular disease, unspecified
0.000 0.309 0.690
M79.7 Fibromyalgia
0.000 0.310 0.690
H35.9 Retinal disorder, unspecified
0.000 0.314 0.686
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.316 0.684
Chapter VIII Diseases of the ear and mastoid process
0.000 0.317 0.683
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.320 0.680
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.322 0.677
I44.7 Left bundle-branch block, unspecified
0.000 0.322 0.678
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.324 0.676
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.324 0.676
H35.6 Retinal haemorrhage
0.000 0.326 0.673
I49.0 Ventricular fibrillation and flutter
0.000 0.330 0.670
I52 Other heart disorders in diseases classified elsewhere
0.000 0.330 0.670
I48 Atrial fibrillation and flutter
0.000 0.330 0.670
I41 Myocarditis in diseases classified elsewhere
0.000 0.330 0.670
I40 Acute myocarditis
0.000 0.330 0.670
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.330 0.670
I32 Pericarditis in diseases classified elsewhere
0.000 0.330 0.670
M79.64 Pain in limb (Hand)
0.000 0.330 0.670
I51.3 Intracardiac thrombosis, not elsewhere classified
0.000 0.334 0.666
E84 Cystic fibrosis
0.000 0.334 0.666
H25.1 Senile nuclear cataract
0.000 0.335 0.665
M70.6 Trochanteric bursitis
0.000 0.338 0.662
E11.6 With other specified complications
0.000 0.340 0.660
M14 Arthropathies in other diseases classified elsewhere
0.000 0.340 0.660
I11 Hypertensive heart disease
0.000 0.340 0.659
K90.9 Intestinal malabsorption, unspecified
0.000 0.342 0.658
L40.3 Pustulosis palmaris et plantaris
0.000 0.343 0.657
I44.3 Other and unspecified atrioventricular block
0.000 0.343 0.657
I47.0 Reentry ventricular arrhythmia
0.000 0.344 0.656
E05.5 Thyroid crisis or storm
0.000 0.346 0.654
E05.4 Thyrotoxicosis factitia
0.000 0.346 0.654
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.346 0.654
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.346 0.654
H35.1 Retinopathy of prematurity
0.000 0.347 0.653
I51.5 Myocardial degeneration
0.000 0.347 0.653
I51.2 Rupture of papillary muscle, not elsewhere classified
0.000 0.347 0.653
K72 Hepatic failure, not elsewhere classified
0.000 0.347 0.653
I15.8 Other secondary hypertension
0.000 0.348 0.652
I15.2 Hypertension secondary to endocrine disorders
0.000 0.348 0.652
I15.0 Renovascular hypertension
0.000 0.348 0.652
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.349 0.651
H55-H59 Other disorders of eye and adnexa
0.000 0.351 0.649
I49.8 Other specified cardiac arrhythmias
0.000 0.353 0.647
I47.1 Supraventricular tachycardia
0.000 0.353 0.647
M79.62 Pain in limb (Upper arm)
0.000 0.354 0.646
E15 Nondiabetic hypoglycaemic coma
0.000 0.354 0.646
H60-H62 Diseases of external ear
0.000 0.357 0.643
I46.9 Cardiac arrest, unspecified
0.000 0.357 0.643
M70.5 Other bursitis of knee
0.000 0.358 0.642
M79.63 Pain in limb (Forearm)
0.000 0.358 0.642
M76 Enthesopathies of lower limb, excluding foot
0.000 0.358 0.642
E13.8 With unspecified complications
0.000 0.359 0.641
E13.7 With multiple complications
0.000 0.359 0.641
E13.6 With other specified complications
0.000 0.359 0.641
E13.5 With peripheral circulatory complications
0.000 0.359 0.641
E13.4 With neurological complications
0.000 0.359 0.641
E13.3 With ophthalmic complications
0.000 0.359 0.641
E13.2 With renal complications
0.000 0.359 0.641
E13.1 With ketoacidosis
0.000 0.359 0.641
E13.0 With coma
0.000 0.359 0.641
H43.2 Crystalline deposits in vitreous body
0.000 0.361 0.639
H43.0 Vitreous prolapse
0.000 0.361 0.639
H27.0 Aphakia
0.000 0.362 0.638
M79.67 Pain in limb (Ankle and foot)
0.000 0.362 0.638
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.367 0.633
K75 Other inflammatory liver diseases
0.000 0.367 0.633
H27.8 Other specified disorders of lens
0.000 0.368 0.632
M79.60 Pain in limb (Multiple sites)
0.000 0.368 0.632
E07.8 Other specified disorders of thyroid
0.000 0.370 0.630
K73 Chronic hepatitis, not elsewhere classified
0.000 0.370 0.630
I36 Nonrheumatic tricuspid valve disorders
0.000 0.371 0.629
I45.8 Other specified conduction disorders
0.000 0.371 0.629
E46 Unspecified protein-energy malnutrition
0.000 0.372 0.628
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.376 0.624
E07.1 Dyshormogenetic goitre
0.000 0.376 0.624
E07.0 Hypersecretion of calcitonin
0.000 0.376 0.624
I24.1 Dressler's syndrome
0.000 0.377 0.623
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.000 0.379 0.621
M05.8 Other seropositive rheumatoid arthritis
0.000 0.380 0.620
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.380 0.620
M05.2 Rheumatoid vasculitis
0.000 0.380 0.620
M05.1 Rheumatoid lung disease
0.000 0.380 0.620
M05.0 Felty's syndrome
0.000 0.380 0.620
K90.3 Pancreatic steatorrhoea
0.000 0.380 0.620
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.380 0.620
K90.1 Tropical sprue
0.000 0.380 0.620
M79.79 Fibromyalgia (Site unspecified)
0.000 0.380 0.620
M79.2 Neuralgia and neuritis, unspecified
0.000 0.382 0.618
E03.8 Other specified hypothyroidism
0.000 0.382 0.618
I20.1 Angina pectoris with documented spasm
0.000 0.383 0.617
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.383 0.617
M12 Other specific arthropathies
0.000 0.385 0.615
H34.8 Other retinal vascular occlusions
0.000 0.385 0.615
I30 Acute pericarditis
0.000 0.388 0.612
K74.5 Biliary cirrhosis, unspecified
0.000 0.388 0.612
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.388 0.612
I23.8 Other current complications following acute myocardial infarction
0.000 0.391 0.608
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.392 0.608
M79.18 Myalgia (Other)
0.000 0.394 0.606
E11.4 With neurological complications
0.000 0.394 0.606
E85.9 Amyloidosis, unspecified
0.000 0.395 0.605
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.395 0.604
I35.8 Other aortic valve disorders
0.000 0.397 0.603
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.397 0.603
H35.0 Background retinopathy and retinal vascular changes
0.000 0.397 0.603
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.397 0.603
M06.38 Rheumatoid nodule (Other)
0.000 0.397 0.603
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.397 0.603
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.397 0.603
M06.33 Rheumatoid nodule (Forearm)
0.000 0.397 0.603
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.397 0.603
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.397 0.603
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.397 0.603
M07.6 Other enteropathic arthropathies
0.000 0.398 0.602
M07.5 Arthropathy in ulcerative colitis
0.000 0.398 0.602
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.398 0.602
M07.2 Psoriatic spondylitis
0.000 0.398 0.602
M07.1 Arthritis mutilans
0.000 0.398 0.602
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.398 0.602
H60 Otitis externa
0.000 0.399 0.601
H35.7 Separation of retinal layers
0.000 0.399 0.600
M70.46 Prepatellar bursitis-Lower Leg
0.000 0.401 0.599
M75.9 Shoulder lesion, unspecified
0.000 0.404 0.596
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.404 0.596
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.404 0.596
E16.4 Abnormal secretion of gastrin
0.000 0.404 0.596
E16.3 Increased secretion of glucagon
0.000 0.404 0.596
E16.1 Other hypoglycaemia
0.000 0.404 0.596
E11.8 With unspecified complications
0.000 0.405 0.595
H28 Cataract and other disorders of lens in diseases classified elsewhere
0.000 0.405 0.595
M70.9 Unspecified soft tissue disorder related to use, overuse and pressure
0.000 0.405 0.595
M70.8 Other soft tissue disorders related to use, overuse and pressure
0.000 0.405 0.595
M70.3 Other bursitis of elbow
0.000 0.405 0.595
M70.1 Bursitis of hand
0.000 0.405 0.595
M70.0 Chronic crepitant synovitis of hand and wrist
0.000 0.405 0.595
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.406 0.594
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.406 0.594
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.406 0.594
E74.2 Disorders of galactose metabolism
0.000 0.406 0.594
E74.1 Disorders of fructose metabolism
0.000 0.406 0.594
E74.0 Glycogen storage disease
0.000 0.406 0.594
L10-L14 Bullous disorders
0.000 0.406 0.594
M79.69 Pain in limb (Site unspecified)
0.000 0.407 0.593
I25.4 Coronary artery aneurysm
0.000 0.408 0.592
I45.2 Bifascicular block
0.000 0.410 0.590
M71.2 Synovial cyst of popliteal space [Baker]
0.000 0.410 0.590
I45.1 Other and unspecified right bundle-branch block
0.000 0.411 0.589
M06.0 Seronegative rheumatoid arthritis
0.000 0.411 0.589
M79.3 Panniculitis, unspecified
0.000 0.412 0.588
K74.6 Other and unspecified cirrhosis of liver
0.000 0.413 0.587
H43.1 Vitreous haemorrhage
0.000 0.413 0.587
K90.8 Other intestinal malabsorption
0.000 0.413 0.586
M79.9 Soft tissue disorder, unspecified
0.000 0.416 0.584
M94 Other disorders of cartilage
0.000 0.417 0.583
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.419 0.581
H34.1 Central retinal artery occlusion
0.000 0.420 0.580
E05.8 Other thyrotoxicosis
0.000 0.421 0.579
I31 Other diseases of pericardium
0.000 0.422 0.578
I35.9 Aortic valve disorder, unspecified
0.000 0.422 0.578
M49.5 Collapsed vertebra in diseases classified elsewhere
0.000 0.422 0.577
M77.1 Lateral epicondylitis
0.000 0.423 0.577
E83.9 Disorder of mineral metabolism, unspecified
0.537 0.424 0.039
E83.8 Other disorders of mineral metabolism
0.537 0.424 0.039
E83.2 Disorders of zinc metabolism
0.537 0.424 0.039
E83.0 Disorders of copper metabolism
0.537 0.424 0.039
E06 Thyroiditis
0.000 0.424 0.576
I49.9 Cardiac arrhythmia, unspecified
0.000 0.425 0.575
I44.4 Left anterior fascicular block
0.000 0.428 0.572
H60.9 Otitis externa, unspecified
0.000 0.428 0.572
Chapter VI Diseases of the nervous system
0.565 0.431 0.003
I44.5 Left posterior fascicular block
0.000 0.432 0.567
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.433 0.566
E89.3 Postprocedural hypopituitarism
0.000 0.435 0.565
I44.1 Atrioventricular block, second degree
0.000 0.436 0.564
E88 Other metabolic disorders
0.000 0.438 0.562
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.438 0.562
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.438 0.562
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.438 0.562
E45 Retarded development following protein-energy malnutrition
0.000 0.438 0.562
E43 Unspecified severe protein-energy malnutrition
0.000 0.438 0.562
E42 Marasmic kwashiorkor
0.000 0.438 0.562
E41 Nutritional marasmus
0.000 0.438 0.562
E40 Kwashiorkor
0.000 0.438 0.562
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.441 0.559
I37 Pulmonary valve disorders
0.000 0.442 0.557
M46 Other inflammatory spondylopathies
0.000 0.444 0.556
M11.2 Other chondrocalcinosis
0.000 0.445 0.555
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.446 0.554
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.446 0.554
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.446 0.554
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.446 0.554
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.446 0.554
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.446 0.554
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.446 0.554
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.446 0.554
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.446 0.553
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.446 0.553
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.446 0.553
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.446 0.553
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.446 0.553
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.446 0.553
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.446 0.553
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.447 0.553
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.447 0.553
M79.19 Myalgia (Site unspecified)
0.000 0.447 0.553
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.448 0.552
H55 Nystagmus and other irregular eye movements
0.000 0.449 0.551
K72.0 Acute and subacute hepatic failure
0.000 0.450 0.550
M65-M68 Disorders of synovium and tendon
0.000 0.450 0.550
I45.5 Other specified heart block
0.000 0.451 0.549
E73 Lactose intolerance
0.001 0.456 0.544
H34.2 Other retinal artery occlusions
0.000 0.456 0.544
M70.7 Other bursitis of hip
0.000 0.457 0.543
G20-G26 Extrapyramidal and movement disorders
0.543 0.457 0.001
H34.0 Transient retinal artery occlusion
0.000 0.457 0.543
J45 Asthma
0.000 0.457 0.543
M70.2 Olecranon bursitis
0.000 0.457 0.542
I45.3 Trifascicular block
0.000 0.458 0.542
M70.65 Trochanteric bursitis-Pelvic/Thigh
0.000 0.458 0.542
M77.5 Other enthesopathy of foot
0.000 0.459 0.541
K72.9 Hepatic failure, unspecified
0.000 0.459 0.541
I45.4 Nonspecific intraventricular block
0.000 0.461 0.539
M86-M90 Other osteopathies
0.000 0.462 0.538
M49.8 Spondylopathy in other diseases classified elsewhere
0.000 0.462 0.537
M49.4 Neuropathic spondylopathy
0.000 0.462 0.537
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere
0.000 0.462 0.537
M49.2 Enterobacterial spondylitis
0.000 0.462 0.537
M49.1 Brucella spondylitis
0.000 0.462 0.537
M49.0 Tuberculosis of spine
0.000 0.462 0.537
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.463 0.537
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.000 0.463 0.537
H31 Other disorders of choroid
0.000 0.463 0.537
M79.15 Myalgia (Pelvic region and thigh)
0.000 0.464 0.536
E85.8 Other amyloidosis
0.000 0.464 0.536
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.464 0.536
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.464 0.536
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.464 0.536
I46.1 Sudden cardiac death, so described
0.000 0.464 0.535
H27.9 Disorder of lens, unspecified
0.000 0.465 0.535
K75.4 Autoimmune hepatitis
0.000 0.465 0.535
G20 Parkinson's disease
0.534 0.466 0.000
I44.6 Other and unspecified fascicular block
0.000 0.468 0.532
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.468 0.532
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.468 0.532
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.468 0.532
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.468 0.532
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.468 0.532
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.468 0.532

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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