TreeWAS – Variant ID: rs28667337

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Click here to show this figure without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
I30-I52 Other forms of heart disease	1.000	0.000	0.000
Chapter IX Diseases of the circulatory system	1.000	0.000	0.000
# Top node	1.000	0.000	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	1.000	0.000	0.000
I20-I25 Ischaemic heart diseases	1.000	0.000	0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.999	0.001	0.000
T81 Complications of procedures, not elsewhere classified	0.998	0.002	0.000
Chapter II Neoplasms	0.995	0.005	0.000
I20 Angina pectoris	0.994	0.006	0.000
I51 Complications and ill-defined descriptions of heart disease	0.994	0.006	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.993	0.007	0.000
I25 Chronic ischaemic heart disease	0.993	0.007	0.000
I51.7 Cardiomegaly	0.990	0.010	0.000
E70-E90 Metabolic disorders	0.988	0.012	0.000
I10-I15 Hypertensive diseases	0.988	0.012	0.000
T81.4 Infection following a procedure, not elsewhere classified	0.985	0.015	0.000
C43-C44 Melanoma and other malignant neoplasms of skin	0.983	0.017	0.000
Chapter XV Pregnancy, childbirth and the puerperium	0.962	0.038	0.000
I20.9 Angina pectoris, unspecified	0.962	0.038	0.000
D10-D36 Benign neoplasms	0.961	0.039	0.000
C44 Other malignant neoplasms of skin	0.956	0.044	0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.954	0.046	0.000
T81.0 Haemorrhage and haematoma complicating a procedure, not elsewhere classified	0.951	0.049	0.000
I60-I69 Cerebrovascular diseases	0.949	0.051	0.000
I44 Atrioventricular and left bundle-branch block	0.947	0.053	0.000
C44.5 Skin of trunk	0.942	0.058	0.000
I12 Hypertensive renal disease	0.941	0.059	0.000
E78.0 Pure hypercholesterolaemia	0.939	0.061	0.000
I20.0 Unstable angina	0.939	0.061	0.000
I42 Cardiomyopathy	0.932	0.068	0.000
I10 Essential (primary) hypertension	0.924	0.076	0.000
I25.8 Other forms of chronic ischaemic heart disease	0.923	0.077	0.000
I44.7 Left bundle-branch block, unspecified	0.923	0.077	0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts	0.915	0.085	0.000
D23 Other benign neoplasms of skin	0.908	0.092	0.000
T88 Other complications of surgical and medical care, not elsewhere classified	0.905	0.095	0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.901	0.099	0.000
Chapter I Certain infectious and parasitic diseases	0.901	0.099	0.000
I05-I09 Chronic rheumatic heart diseases	0.897	0.103	0.000
I45 Other conduction disorders	0.896	0.104	0.000
I25.2 Old myocardial infarction	0.895	0.105	0.000
C43 Malignant melanoma of skin	0.894	0.106	0.000
T81.3 Disruption of operation wound, not elsewhere classified	0.889	0.111	0.000
E20-E35 Disorders of other endocrine glands	0.883	0.117	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.880	0.120	0.000
Chapter X Diseases of the respiratory system	0.879	0.121	0.000
E87 Other disorders of fluid, electrolyte and acid-base balance	0.878	0.122	0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction	0.873	0.127	0.000
I12.0 Hypertensive renal disease with renal failure	0.867	0.133	0.000
K80-K87 Disorders of gallbladder, biliary tract and pancreas	0.867	0.133	0.000
S80-S89 Injuries to the knee and lower leg	0.867	0.133	0.000
Chapter XI Diseases of the digestive system	0.866	0.134	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.865	0.135	0.000
D23.7 Skin of lower limb, including hip	0.862	0.138	0.000
S50-S59 Injuries to the elbow and forearm	0.862	0.138	0.000
I25.1 Atherosclerotic heart disease	0.859	0.141	0.000
I38 Endocarditis, valve unspecified	0.856	0.144	0.000
D37-D48 Neoplasms of uncertain or unknown behaviour	0.855	0.145	0.000
I49 Other cardiac arrhythmias	0.854	0.145	0.000
D00-D09 In situ neoplasms	0.853	0.147	0.000
I64 Stroke, not specified as haemorrhage or infarction	0.852	0.148	0.000
O60-O75 Complications of labour and delivery	0.850	0.150	0.000
J30-J39 Other diseases of upper respiratory tract	0.849	0.151	0.000
D35 Benign neoplasm of other and unspecified endocrine glands	0.849	0.151	0.000
I25.9 Chronic ischaemic heart disease, unspecified	0.849	0.151	0.000
C44.7 Skin of lower limb, including hip	0.844	0.156	0.000
K80 Cholelithiasis	0.840	0.160	0.000
I46 Cardiac arrest	0.833	0.167	0.000
E83 Disorders of mineral metabolism	0.833	0.167	0.000
D27 Benign neoplasm of ovary	0.832	0.168	0.000
O00-O08 Pregnancy with abortive outcome	0.830	0.170	0.000
I20.8 Other forms of angina pectoris	0.828	0.172	0.000
I61 Intracerebral haemorrhage	0.827	0.173	0.000
I12.9 Hypertensive renal disease without renal failure	0.823	0.177	0.000
C15-C26 Malignant neoplasms of digestive organs	0.822	0.178	0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts	0.821	0.179	0.000
B95-B98 Bacterial, viral and other infectious agents	0.820	0.180	0.000
D14 Benign neoplasm of middle ear and respiratory system	0.819	0.181	0.000
I35 Nonrheumatic aortic valve disorders	0.818	0.182	0.000
I65.2 Occlusion and stenosis of carotid artery	0.818	0.182	0.000
C43.5 Malignant melanoma of trunk	0.815	0.185	0.000
I50 Heart failure	0.808	0.192	0.000
E87.2 Acidosis	0.806	0.194	0.000
M50-M54 Other dorsopathies	0.801	0.199	0.000
O34 Maternal care for known or suspected abnormality of pelvic organs	0.799	0.201	0.000
E78.2 Mixed hyperlipidaemia	0.798	0.202	0.000
I95-I99 Other and unspecified disorders of the circulatory system	0.798	0.202	0.000
K80.0 Calculus of gallbladder with acute cholecystitis	0.795	0.205	0.000
Chapter XII Diseases of the skin and subcutaneous tissue	0.795	0.205	0.000
T15-T19 Effects of foreign body entering through natural orifice	0.794	0.206	0.000
Chapter VIII Diseases of the ear and mastoid process	0.793	0.207	0.000
I47 Paroxysmal tachycardia	0.792	0.208	0.000
T88.4 Failed or difficult intubation	0.791	0.209	0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.790	0.210	0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.789	0.211	0.000
Chapter XX External causes of morbidity and mortality	0.789	0.211	0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified	0.788	0.212	0.000
I45.1 Other and unspecified right bundle-branch block	0.787	0.213	0.000
O36 Maternal care for other known or suspected foetal problems	0.782	0.217	0.000
Chapter XIV Diseases of the genitourinary system	0.781	0.219	0.001
I34 Nonrheumatic mitral valve disorders	0.780	0.220	0.000
K83 Other diseases of biliary tract	0.780	0.220	0.000
T66-T78 Other and unspecified effects of external causes	0.779	0.221	0.000
K80.2 Calculus of gallbladder without cholecystitis	0.777	0.223	0.000
E89.0 Postprocedural hypothyroidism	0.777	0.223	0.000
I60 Subarachnoid haemorrhage	0.776	0.224	0.000
M65-M68 Disorders of synovium and tendon	0.776	0.224	0.000
I24 Other acute ischaemic heart diseases	0.774	0.226	0.000
I08 Multiple valve diseases	0.774	0.226	0.000
I42.0 Dilated cardiomyopathy	0.774	0.226	0.000
S20-S29 Injuries to the thorax	0.772	0.228	0.000
D10 Benign neoplasm of mouth and pharynx	0.770	0.230	0.000
K81 Cholecystitis	0.770	0.230	0.000
T79-T79 Certain early complications of trauma	0.769	0.231	0.000
I49.0 Ventricular fibrillation and flutter	0.767	0.233	0.000
S60-S69 Injuries to the wrist and hand	0.767	0.233	0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands	0.765	0.235	0.000
N17-N19 Renal failure	0.758	0.242	0.000
I11 Hypertensive heart disease	0.757	0.243	0.000
D11 Benign neoplasm of major salivary glands	0.756	0.244	0.000
I42.2 Other hypertrophic cardiomyopathy	0.755	0.245	0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts	0.755	0.245	0.000
I42.1 Obstructive hypertrophic cardiomyopathy	0.755	0.245	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.755	0.245	0.000
N10-N16 Renal tubulo-interstitial diseases	0.754	0.246	0.000
I42.9 Cardiomyopathy, unspecified	0.753	0.247	0.000
T81.8 Other complications of procedures, not elsewhere classified	0.753	0.247	0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters	0.751	0.249	0.000
S70-S79 Injuries to the hip and thigh	0.750	0.250	0.000
I25.5 Ischaemic cardiomyopathy	0.750	0.250	0.000
L80-L99 Other disorders of the skin and subcutaneous tissue	0.749	0.251	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.748	0.252	0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts	0.746	0.254	0.000
D26 Other benign neoplasms of uterus	0.746	0.254	0.000
M54 Dorsalgia	0.744	0.256	0.000
T88.6 Anaphylactic shock due to adverse effect of correct drug or medicament properly administered	0.744	0.256	0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.743	0.257	0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.743	0.257	0.000
I07 Rheumatic tricuspid valve diseases	0.743	0.257	0.000
E50-E64 Other nutritional deficiencies	0.741	0.259	0.000
I50.0 Congestive heart failure	0.741	0.259	0.000
D32 Benign neoplasm of meninges	0.739	0.261	0.000
I61.9 Intracerebral haemorrhage, unspecified	0.739	0.261	0.000
O02 Other abnormal products of conception	0.737	0.263	0.000
E87.7 Fluid overload	0.736	0.264	0.000
L82 Seborrhoeic keratosis	0.735	0.265	0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.733	0.267	0.000
S40-S49 Injuries to the shoulder and upper arm	0.732	0.268	0.000
M40-M43 Deforming dorsopathies	0.731	0.269	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.731	0.269	0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee	0.731	0.269	0.000
J90-J94 Other diseases of pleura	0.730	0.270	0.000
D23.5 Skin of trunk	0.729	0.271	0.000
C43.6 Malignant melanoma of upper limb, including shoulder	0.729	0.271	0.000
J34 Other disorders of nose and nasal sinuses	0.728	0.272	0.000
E83.1 Disorders of iron metabolism	0.728	0.272	0.000
N13 Obstructive and reflux uropathy	0.728	0.272	0.000
E80 Disorders of porphyrin and bilirubin metabolism	0.727	0.273	0.000
N17 Acute renal failure	0.727	0.273	0.000
O34.2 Maternal care due to uterine scar from previous surgery	0.726	0.274	0.000
I44.1 Atrioventricular block, second degree	0.726	0.274	0.000
I45.9 Conduction disorder, unspecified	0.724	0.275	0.000
D33 Benign neoplasm of brain and other parts of central nervous system	0.724	0.275	0.000
D36 Benign neoplasm of other and unspecified sites	0.723	0.277	0.000
K85 Acute pancreatitis	0.722	0.278	0.000
C20 Malignant neoplasm of rectum	0.722	0.278	0.000
D35.1 Parathyroid gland	0.721	0.279	0.000
Chapter XXII Codes for special purposes	0.721	0.279	0.000
I51.8 Other ill-defined heart diseases	0.719	0.281	0.000
D14.0 Middle ear, nasal cavity and accessory sinuses	0.718	0.282	0.000
D13 Benign neoplasm of other and ill-defined parts of digestive system	0.718	0.282	0.000
I52 Other heart disorders in diseases classified elsewhere	0.717	0.283	0.000
I48 Atrial fibrillation and flutter	0.717	0.283	0.000
I43 Cardiomyopathy in diseases classified elsewhere	0.717	0.283	0.000
I41 Myocarditis in diseases classified elsewhere	0.717	0.283	0.000
I40 Acute myocarditis	0.717	0.283	0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.717	0.283	0.000
I37 Pulmonary valve disorders	0.717	0.283	0.000
I36 Nonrheumatic tricuspid valve disorders	0.717	0.283	0.000
I33 Acute and subacute endocarditis	0.717	0.283	0.000
I32 Pericarditis in diseases classified elsewhere	0.717	0.283	0.000
I30 Acute pericarditis	0.717	0.283	0.000
I00-I02 Acute rheumatic fever	0.717	0.283	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283	0.000
T33-T35 Frostbite	0.717	0.283	0.000
T26-T28 Burns and corrosions confined to eye and internal organs	0.717	0.283	0.000
T20-T25 Burns and corrosions of external body surface, specified by site	0.717	0.283	0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.717	0.283	0.000
T00-T07 Injuries involving multiple body regions	0.717	0.283	0.000
S10-S19 Injuries to the neck	0.717	0.283	0.000
I23 Certain current complications following acute myocardial infarction	0.717	0.283	0.000
T87 Complications peculiar to reattachment and amputation	0.717	0.283	0.000
T86 Failure and rejection of transplanted organs and tissues	0.717	0.283	0.000
T80 Complications following infusion, transfusion and therapeutic injection	0.717	0.283	0.000
C44.0 Skin of lip	0.716	0.284	0.000
T81.9 Unspecified complication of procedure	0.716	0.284	0.000
T81.7 Vascular complications following a procedure, not elsewhere classified	0.716	0.284	0.000
T81.6 Acute reaction to foreign substance accidentally left during a procedure	0.716	0.284	0.000
T81.5 Foreign body accidentally left in body cavity or operation wound following a procedure	0.716	0.284	0.000
T81.1 Shock during or resulting from a procedure, not elsewhere classified	0.716	0.284	0.000
E28 Ovarian dysfunction	0.714	0.286	0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites	0.714	0.286	0.000
C40-C41 Malignant neoplasms of bone and articular cartilage	0.714	0.286	0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.714	0.286	0.000
I20.1 Angina pectoris with documented spasm	0.713	0.287	0.000
I47.2 Ventricular tachycardia	0.713	0.287	0.000
I51.6 Cardiovascular disease, unspecified	0.713	0.287	0.000
I51.5 Myocardial degeneration	0.713	0.287	0.000
I51.4 Myocarditis, unspecified	0.713	0.287	0.000
I51.3 Intracardiac thrombosis, not elsewhere classified	0.713	0.287	0.000
I51.2 Rupture of papillary muscle, not elsewhere classified	0.713	0.287	0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified	0.713	0.287	0.000
I51.0 Cardiac septal defect, acquired	0.713	0.287	0.000
E40-E46 Malnutrition	0.712	0.288	0.000
I25.6 Silent myocardial ischaemia	0.712	0.288	0.000
I25.4 Coronary artery aneurysm	0.712	0.288	0.000
I25.3 Aneurysm of heart	0.712	0.288	0.000
I25.0 Atherosclerotic cardiovascular disease, so described	0.712	0.288	0.000
D21 Other benign neoplasms of connective and other soft tissue	0.712	0.288	0.000
D23.3 Skin of other and unspecified parts of face	0.711	0.288	0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.710	0.290	0.000
E88 Other metabolic disorders	0.709	0.291	0.000
E85 Amyloidosis	0.709	0.291	0.000
E84 Cystic fibrosis	0.709	0.291	0.000
E79 Disorders of purine and pyrimidine metabolism	0.709	0.291	0.000
E77 Disorders of glycoprotein metabolism	0.709	0.291	0.000
E76 Disorders of glycosaminoglycan metabolism	0.709	0.291	0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.709	0.291	0.000
E74 Other disorders of carbohydrate metabolism	0.709	0.291	0.000
E73 Lactose intolerance	0.709	0.291	0.000
E72 Other disorders of amino-acid metabolism	0.709	0.291	0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.709	0.291	0.000
E70 Disorders of aromatic amino-acid metabolism	0.709	0.291	0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.709	0.291	0.000
I15 Secondary hypertension	0.708	0.292	0.000
I13 Hypertensive heart and renal disease	0.708	0.292	0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs	0.708	0.292	0.000
S51 Open wound of forearm	0.708	0.292	0.000
A00-A09 Intestinal infectious diseases	0.706	0.294	0.000
J38.7 Other diseases of larynx	0.705	0.295	0.000
N17.9 Acute renal failure, unspecified	0.705	0.295	0.000
S52 Fracture of forearm	0.705	0.295	0.000
S90-S99 Injuries to the ankle and foot	0.704	0.296	0.000
J60-J70 Lung diseases due to external agents	0.702	0.298	0.000
T81.2 Accidental puncture and laceration during a procedure, not elsewhere classified	0.702	0.298	0.000
D35.0 Adrenal gland	0.698	0.302	0.000
O46 Antepartum haemorrhage, not elsewhere classified	0.694	0.306	0.000
B25-B34 Other viral diseases	0.694	0.306	0.000
D09 Carcinoma in situ of other and unspecified sites	0.693	0.306	0.000
K83.8 Other specified diseases of biliary tract	0.693	0.307	0.000
O94-O99 Other obstetric conditions, not elsewhere classified	0.693	0.307	0.000
C43.3 Malignant melanoma of other and unspecified parts of face	0.691	0.309	0.000
O41 Other disorders of amniotic fluid and membranes	0.690	0.310	0.000
O85-O92 Complications predominantly related to the puerperium	0.690	0.310	0.000
I08.0 Disorders of both mitral and aortic valves	0.690	0.310	0.000
D31 Benign neoplasm of eye and adnexa	0.689	0.311	0.000
D30 Benign neoplasm of urinary organs	0.689	0.311	0.000
D29 Benign neoplasm of male genital organs	0.689	0.311	0.000
D28 Benign neoplasm of other and unspecified female genital organs	0.689	0.311	0.000
D20 Benign neoplasm of soft tissue of retroperitoneum and peritoneum	0.689	0.311	0.000
D19 Benign neoplasm of mesothelial tissue	0.689	0.311	0.000
D16 Benign neoplasm of bone and articular cartilage	0.689	0.311	0.000
D15 Benign neoplasm of other and unspecified intrathoracic organs	0.689	0.311	0.000
E65-E68 Obesity and other hyperalimentation	0.688	0.312	0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.688	0.312	0.000
C44.9 Malignant neoplasm of skin, unspecified	0.686	0.314	0.000
C44.8 Overlapping lesion of skin	0.686	0.314	0.000
E86 Volume depletion	0.685	0.315	0.000
E78.9 Disorder of lipoprotein metabolism, unspecified	0.684	0.316	0.000
E78.8 Other disorders of lipoprotein metabolism	0.684	0.316	0.000
E78.6 Lipoprotein deficiency	0.684	0.316	0.000
E78.4 Other hyperlipidaemia	0.684	0.316	0.000
E78.3 Hyperchylomicronaemia	0.684	0.316	0.000
E78.1 Pure hyperglyceridaemia	0.684	0.316	0.000
I46.9 Cardiac arrest, unspecified	0.683	0.317	0.000
D34 Benign neoplasm of thyroid gland	0.681	0.319	0.000
I68 Cerebrovascular disorders in diseases classified elsewhere	0.681	0.319	0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction	0.681	0.319	0.000
N18 Chronic renal failure	0.680	0.320	0.000
O47 False labour	0.680	0.320	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.679	0.320	0.000
K82 Other diseases of gallbladder	0.679	0.321	0.000
I44.6 Other and unspecified fascicular block	0.679	0.321	0.000
I44.5 Left posterior fascicular block	0.679	0.321	0.000
I44.4 Left anterior fascicular block	0.679	0.321	0.000
I44.3 Other and unspecified atrioventricular block	0.679	0.321	0.000
I22 Subsequent myocardial infarction	0.678	0.322	0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract	0.678	0.322	0.000
I51.9 Heart disease, unspecified	0.677	0.323	0.000
J30 Vasomotor and allergic rhinitis	0.676	0.324	0.000
C64-C68 Malignant neoplasms of urinary tract	0.675	0.325	0.000
A80-A89 Viral infections of the central nervous system	0.674	0.326	0.000
O63 Long labour	0.674	0.326	0.000
E27 Other disorders of adrenal gland	0.673	0.327	0.000
B95.7 Other staphylococcus as the cause of diseases classified to other chapters	0.672	0.328	0.000
K80.5 Calculus of bile duct without cholangitis or cholecystitis	0.672	0.328	0.000
O02.1 Missed abortion	0.671	0.329	0.000
K81.0 Acute cholecystitis	0.669	0.330	0.000
M45-M49 Spondylopathies	0.669	0.331	0.000
M80-M85 Disorders of bone density and structure	0.668	0.332	0.000
I42.8 Other cardiomyopathies	0.668	0.332	0.000
I42.7 Cardiomyopathy due to drugs and other external agents	0.668	0.332	0.000
I42.6 Alcoholic cardiomyopathy	0.668	0.332	0.000
I42.5 Other restrictive cardiomyopathy	0.668	0.332	0.000
I42.4 Endocardial fibroelastosis	0.668	0.332	0.000
I42.3 Endomyocardial (eosinophilic) disease	0.668	0.332	0.000
B15-B19 Viral hepatitis	0.667	0.332	0.000
K70-K77 Diseases of liver	0.667	0.332	0.000
M65 Synovitis and tenosynovitis	0.667	0.333	0.000
D03 Melanoma in situ	0.667	0.333	0.000
I35.8 Other aortic valve disorders	0.667	0.333	0.000
N13.3 Other and unspecified hydronephrosis	0.667	0.333	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.665	0.335	0.000
T88.7 Unspecified adverse effect of drug or medicament	0.665	0.335	0.000
O36.0 Maternal care for rhesus isoimmunisation	0.664	0.336	0.000
I49.3 Ventricular premature depolarisation	0.664	0.336	0.000
I62 Other nontraumatic intracranial haemorrhage	0.661	0.339	0.000
D06 Carcinoma in situ of cervix uteri	0.661	0.339	0.000
O66 Other obstructed labour	0.659	0.341	0.000
I44.0 Atrioventricular block, first degree	0.659	0.341	0.000
C19 Malignant neoplasm of rectosigmoid junction	0.658	0.342	0.000
I34.0 Mitral (valve) insufficiency	0.658	0.342	0.000
C16 Malignant neoplasm of stomach	0.658	0.342	0.000
I35.2 Aortic (valve) stenosis with insufficiency	0.656	0.344	0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue	0.656	0.344	0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites	0.656	0.344	0.000
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft	0.656	0.344	0.000
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis	0.656	0.344	0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants	0.656	0.344	0.000
T82.4 Mechanical complication of vascular dialysis catheter	0.656	0.344	0.000
T82.3 Mechanical complication of other vascular grafts	0.656	0.344	0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts	0.656	0.344	0.000
T82.1 Mechanical complication of cardiac electronic device	0.656	0.344	0.000
T82.0 Mechanical complication of heart valve prosthesis	0.656	0.344	0.000
O62 Abnormalities of forces of labour	0.656	0.344	0.000
D41 Neoplasm of uncertain or unknown behaviour of urinary organs	0.656	0.344	0.000
O64 Obstructed labour due to malposition and malpresentation of foetus	0.655	0.345	0.000
O30 Multiple gestation	0.655	0.345	0.000
D07 Carcinoma in situ of other and unspecified genital organs	0.655	0.345	0.000
A50-A64 Infections with a predominantly sexual mode of transmission	0.653	0.347	0.000
I95 Hypotension	0.652	0.347	0.000
I60.9 Subarachnoid haemorrhage, unspecified	0.652	0.348	0.000
O73 Retained placenta and membranes, without haemorrhage	0.652	0.348	0.000
O68 Labour and delivery complicated by foetal stress [distress]	0.652	0.348	0.000
D23.9 Skin, unspecified	0.651	0.349	0.000
D23.2 Skin of ear and external auricular canal	0.651	0.349	0.000
D23.0 Skin of lip	0.651	0.349	0.000
O36.5 Maternal care for poor foetal growth	0.651	0.349	0.000
S32 Fracture of lumbar spine and pelvis	0.651	0.349	0.000
M91-M94 Chondropathies	0.650	0.350	0.000
K86 Other diseases of pancreas	0.650	0.350	0.000
T88.9 Complication of surgical and medical care, unspecified	0.649	0.351	0.000
T88.8 Other specified complications of surgical and medical care, not elsewhere classified	0.649	0.351	0.000
T88.5 Other complications of anaesthesia	0.649	0.351	0.000
T88.3 Malignant hyperthermia due to anaesthesis	0.649	0.351	0.000
T88.2 Shock due to anaesthesia	0.649	0.351	0.000
T88.1 Other complications following immunisation, not elsewhere classified	0.649	0.351	0.000
T88.0 Infection following immunisation	0.649	0.351	0.000
J33 Nasal polyp	0.648	0.352	0.000
C21 Malignant neoplasm of anus and anal canal	0.647	0.352	0.000
H80-H83 Diseases of inner ear	0.647	0.353	0.000
I24.8 Other forms of acute ischaemic heart disease	0.647	0.353	0.000
O45 Premature separation of placenta [abruptio placentae]	0.646	0.354	0.000
O44 Placenta praevia	0.646	0.354	0.000
O43 Placental disorders	0.646	0.354	0.000
O35 Maternal care for known or suspected foetal abnormality and damage	0.646	0.354	0.000
O33 Maternal care for known or suspected disproportion	0.646	0.354	0.000
O31 Complications specific to multiple gestation	0.646	0.354	0.000
O40 Polyhydramnios	0.646	0.354	0.000
E87.5 Hyperkalaemia	0.646	0.354	0.000
B99-B99 Other infectious diseases	0.646	0.354	0.000
B90-B94 Sequelae of infectious and parasitic diseases	0.646	0.354	0.000
B85-B89 Pediculosis, acariasis and other infestations	0.646	0.354	0.000
B65-B83 Helminthiases	0.646	0.354	0.000
B50-B64 Protozoal diseases	0.646	0.354	0.000
B20-B24 Human immunodeficiency virus [HIV] disease	0.646	0.354	0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers	0.646	0.354	0.000
A75-A79 Rickettsioses	0.646	0.354	0.000
A70-A74 Other diseases caused by chlamydiae	0.646	0.354	0.000
A65-A69 Other spirochaetal diseases	0.646	0.354	0.000
A20-A28 Certain zoonotic bacterial diseases	0.646	0.354	0.000
A15-A19 Tuberculosis	0.646	0.354	0.000
D17 Benign lipomatous neoplasm	0.646	0.354	0.000
J38.1 Polyp of vocal cord and larynx	0.646	0.354	0.000
M86-M90 Other osteopathies	0.645	0.355	0.000
I46.0 Cardiac arrest with successful resuscitation	0.645	0.355	0.000
S80 Superficial injury of lower leg	0.645	0.355	0.000
S81 Open wound of lower leg	0.644	0.356	0.000
S82 Fracture of lower leg, including ankle	0.644	0.356	0.000
K65-K67 Diseases of peritoneum	0.643	0.356	0.000
C71 Malignant neoplasm of brain	0.643	0.357	0.000
I09 Other rheumatic heart diseases	0.643	0.357	0.000
I06 Rheumatic aortic valve diseases	0.643	0.357	0.000
I05 Rheumatic mitral valve diseases	0.643	0.357	0.000
I45.8 Other specified conduction disorders	0.643	0.357	0.000
I45.6 Preexcitation syndrome	0.643	0.357	0.000
I45.5 Other specified heart block	0.643	0.357	0.000
I45.4 Nonspecific intraventricular block	0.643	0.357	0.000
I45.3 Trifascicular block	0.643	0.357	0.000
I45.2 Bifascicular block	0.643	0.357	0.000
I45.0 Right fascicular block	0.643	0.357	0.000
D18 Haemangioma and lymphangioma, any site	0.642	0.358	0.000
C43.9 Malignant melanoma of skin, unspecified	0.641	0.359	0.000
C43.8 Overlapping malignant melanoma of skin	0.641	0.359	0.000
C43.4 Malignant melanoma of scalp and neck	0.641	0.359	0.000
C43.2 Malignant melanoma of ear and external auricular canal	0.641	0.359	0.000
C43.1 Malignant melanoma of eyelid, including canthus	0.641	0.359	0.000
C43.0 Malignant melanoma of lip	0.641	0.359	0.000
L60-L75 Disorders of skin appendages	0.641	0.359	0.000
O75 Other complications of labour and delivery, not elsewhere classified	0.639	0.361	0.000
O03 Spontaneous abortion	0.639	0.361	0.000
I21 Acute myocardial infarction	0.639	0.361	0.000
T83.3 Mechanical complication of intra-uterine contraceptive device	0.638	0.361	0.000
S89 Other and unspecified injuries of lower leg	0.637	0.363	0.000
M41 Scoliosis	0.636	0.364	0.000
O36.6 Maternal care for excessive foetal growth	0.636	0.364	0.000
D23.1 Skin of eyelid, including canthus	0.636	0.364	0.000
B95.5 Unspecified streptococcus as the cause of diseases classified to other chapters	0.635	0.365	0.000
J80-J84 Other respiratory diseases principally affecting the interstitium	0.635	0.365	0.000
J35 Chronic diseases of tonsils and adenoids	0.635	0.365	0.000
J90 Pleural effusion, not elsewhere classified	0.635	0.365	0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters	0.635	0.365	0.000
I31 Other diseases of pericardium	0.634	0.365	0.000
K50-K52 Noninfective enteritis and colitis	0.634	0.366	0.000
V40-V49 Car occupant injured in transport accident	0.634	0.366	0.000
D10.1 Tongue	0.634	0.366	0.000
I07.1 Tricuspid insufficiency	0.633	0.367	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.633	0.367	0.000
E34 Other endocrine disorders	0.633	0.367	0.000
E32 Diseases of thymus	0.633	0.367	0.000
E31 Polyglandular dysfunction	0.633	0.367	0.000
E30 Disorders of puberty, not elsewhere classified	0.633	0.367	0.000
E29 Testicular dysfunction	0.633	0.367	0.000
E26 Hyperaldosteronism	0.633	0.367	0.000
E25 Adrenogenital disorders	0.633	0.367	0.000
E24 Cushing's syndrome	0.633	0.367	0.000
E22 Hyperfunction of pituitary gland	0.633	0.367	0.000
E20 Hypoparathyroidism	0.633	0.367	0.000
E23 Hypofunction and other disorders of pituitary gland	0.632	0.368	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.631	0.369	0.000
M60-M63 Disorders of muscles	0.631	0.369	0.000
M00-M03 Infectious arthropathies	0.631	0.369	0.000
C44.1 Skin of eyelid, including canthus	0.629	0.370	0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified	0.629	0.371	0.000
E87.4 Mixed disorder of acid-base balance	0.629	0.371	0.000
E87.3 Alkalosis	0.629	0.371	0.000
E87.0 Hyperosmolality and hypernatraemia	0.629	0.371	0.000
E21.3 Hyperparathyroidism, unspecified	0.629	0.371	0.000
M54.5 Low back pain	0.629	0.371	0.000
C44.2 Skin of ear and external auricular canal	0.627	0.373	0.000
M67 Other disorders of synovium and tendon	0.626	0.374	0.000
I65.9 Occlusion and stenosis of unspecified precerebral artery	0.626	0.374	0.000
I65.8 Occlusion and stenosis of other precerebral artery	0.626	0.374	0.000
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries	0.626	0.374	0.000
I65.1 Occlusion and stenosis of basilar artery	0.626	0.374	0.000
I65.0 Occlusion and stenosis of vertebral artery	0.626	0.374	0.000
S83.2 Tear of meniscus, current	0.624	0.375	0.000
S67 Crushing injury of wrist and hand	0.624	0.376	0.000
I74 Arterial embolism and thrombosis	0.623	0.377	0.000
K87 Disorders of gallbladder, biliary tract and pancreas in diseases classified elsewhere	0.621	0.378	0.000
S88 Traumatic amputation of lower leg	0.621	0.378	0.000
S87 Crushing injury of lower leg	0.621	0.378	0.000
S86 Injury of muscle and tendon at lower leg level	0.621	0.378	0.000
S85 Injury of blood vessels at lower leg level	0.621	0.378	0.000
S84 Injury of nerves at lower leg level	0.621	0.378	0.000
K81.1 Chronic cholecystitis	0.621	0.379	0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.620	0.380	0.000
E89.8 Other postprocedural endocrine and metabolic disorders	0.620	0.380	0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.620	0.380	0.000
E89.5 Postprocedural testicular hypofunction	0.620	0.380	0.000
E89.4 Postprocedural ovarian failure	0.620	0.380	0.000
E89.3 Postprocedural hypopituitarism	0.620	0.380	0.000
E89.2 Postprocedural hypoparathyroidism	0.620	0.380	0.000
E89.1 Postprocedural hypoinsulinaemia	0.620	0.380	0.000
S52.5 Fracture of lower end of radius	0.620	0.380	0.000
T78 Adverse effects, not elsewhere classified	0.620	0.380	0.000
H90-H95 Other disorders of ear	0.620	0.380	0.000
T17 Foreign body in respiratory tract	0.620	0.380	0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions	0.620	0.380	0.000
V10-V19 Pedal cyclist injured in transport accident	0.618	0.381	0.000
S59 Other and unspecified injuries of forearm	0.618	0.382	0.000
S58 Traumatic amputation of forearm	0.618	0.382	0.000
S57 Crushing injury of forearm	0.618	0.382	0.000
S56 Injury of muscle and tendon at forearm level	0.618	0.382	0.000
S55 Injury of blood vessels at forearm level	0.618	0.382	0.000
S54 Injury of nerves at forearm level	0.618	0.382	0.000
S53 Dislocation, sprain and strain of joints and ligaments of elbow	0.618	0.382	0.000
S50 Superficial injury of forearm	0.618	0.382	0.000
O00 Ectopic pregnancy	0.616	0.384	0.000
J32 Chronic sinusitis	0.616	0.384	0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts	0.615	0.384	0.000
C44.4 Skin of scalp and neck	0.614	0.386	0.000
N00-N08 Glomerular diseases	0.613	0.386	0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands	0.613	0.387	0.000
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system	0.613	0.387	0.000
D42 Neoplasm of uncertain or unknown behaviour of meninges	0.613	0.387	0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs	0.613	0.387	0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs	0.613	0.387	0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs	0.613	0.387	0.000
I49.5 Sick sinus syndrome	0.613	0.387	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations