TreeWAS – Variant ID: rs28875200

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
# Top node	0.902	0.098	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.876	0.124	0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	0.866	0.134	0.000
Chapter XI Diseases of the digestive system	0.853	0.147	0.000
Chapter IX Diseases of the circulatory system	0.834	0.166	0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems	0.828	0.172	0.000
E10-E14 Diabetes mellitus	0.804	0.196	0.000
K20-K31 Diseases of oesophagus, stomach and duodenum	0.799	0.201	0.000
I20-I25 Ischaemic heart diseases	0.792	0.208	0.000
E70-E90 Metabolic disorders	0.789	0.211	0.000
Chapter VI Diseases of the nervous system	0.785	0.215	0.000
R07 Pain in throat and chest	0.760	0.240	0.000
Chapter XXI Factors influencing health status and contact with health services	0.755	0.245	0.000
E11 Non-insulin-dependent diabetes mellitus	0.753	0.247	0.000
K21 Gastro-oesophageal reflux disease	0.753	0.247	0.000
Chapter XIV Diseases of the genitourinary system	0.737	0.263	0.000
Chapter XV Pregnancy, childbirth and the puerperium	0.735	0.265	0.000
I20 Angina pectoris	0.727	0.273	0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.727	0.273	0.000
R07.4 Chest pain, unspecified	0.718	0.282	0.000
E65-E68 Obesity and other hyperalimentation	0.716	0.284	0.000
E11.9 Without complications	0.716	0.284	0.000
K21.9 Gastro-oesophageal reflux disease without oesophagitis	0.715	0.285	0.000
Chapter I Certain infectious and parasitic diseases	0.711	0.289	0.000
Chapter VII Diseases of the eye and adnexa	0.709	0.291	0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis	0.700	0.300	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.699	0.301	0.000
Chapter X Diseases of the respiratory system	0.695	0.305	0.000
Chapter XII Diseases of the skin and subcutaneous tissue	0.692	0.308	0.000
K30 Dyspepsia	0.689	0.311	0.000
E78.0 Pure hypercholesterolaemia	0.682	0.318	0.000
Chapter V Mental and behavioural disorders	0.680	0.320	0.000
G50-G59 Nerve, nerve root and plexus disorders	0.675	0.325	0.000
R05 Cough	0.667	0.333	0.000
R03 Abnormal blood-pressure reading, without diagnosis	0.665	0.335	0.000
R30-R39 Symptoms and signs involving the urinary system	0.665	0.335	0.000
I20.0 Unstable angina	0.663	0.337	0.000
K50-K52 Noninfective enteritis and colitis	0.663	0.337	0.000
I25 Chronic ischaemic heart disease	0.662	0.337	0.000
N40-N51 Diseases of male genital organs	0.662	0.338	0.000
R50-R69 General symptoms and signs	0.661	0.339	0.000
Chapter VIII Diseases of the ear and mastoid process	0.651	0.349	0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws	0.647	0.353	0.000
Chapter XXII Codes for special purposes	0.646	0.353	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.646	0.353	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.646	0.353	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.638	0.362	0.000
K55-K64 Other diseases of intestines	0.638	0.362	0.000
R00 Abnormalities of heart beat	0.636	0.364	0.000
E50-E64 Other nutritional deficiencies	0.628	0.372	0.000
E40-E46 Malnutrition	0.628	0.372	0.000
E20-E35 Disorders of other endocrine glands	0.628	0.372	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.628	0.372	0.000
K65-K67 Diseases of peritoneum	0.627	0.373	0.000
I95-I99 Other and unspecified disorders of the circulatory system	0.625	0.375	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.624	0.376	0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis	0.623	0.376	0.000
K90-K93 Other diseases of the digestive system	0.623	0.377	0.000
I30-I52 Other forms of heart disease	0.622	0.378	0.000
R95-R99 Ill-defined and unknown causes of mortality	0.621	0.379	0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis	0.621	0.379	0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis	0.621	0.379	0.000
R47-R49 Symptoms and signs involving speech and voice	0.621	0.379	0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour	0.621	0.379	0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems	0.621	0.379	0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue	0.621	0.379	0.000
G40-G47 Episodic and paroxysmal disorders	0.615	0.385	0.000
R04 Haemorrhage from respiratory passages	0.615	0.385	0.000
I21 Acute myocardial infarction	0.614	0.386	0.000
K70-K77 Diseases of liver	0.612	0.388	0.000
K35-K38 Diseases of appendix	0.612	0.388	0.000
O80-O84 Delivery	0.605	0.394	0.000
K25 Gastric ulcer	0.604	0.396	0.000
E66 Obesity	0.602	0.398	0.000
E00-E07 Disorders of thyroid gland	0.599	0.401	0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status	0.598	0.402	0.000
I60-I69 Cerebrovascular diseases	0.598	0.402	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.598	0.402	0.000
I05-I09 Chronic rheumatic heart diseases	0.598	0.402	0.000
I00-I02 Acute rheumatic fever	0.598	0.402	0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction	0.596	0.404	0.000
Chapter XX External causes of morbidity and mortality	0.595	0.405	0.000
K40-K46 Hernia	0.595	0.405	0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems	0.594	0.406	0.000
R01 Cardiac murmurs and other cardiac sounds	0.594	0.406	0.000
R02 Gangrene, not elsewhere classified	0.594	0.406	0.000
Z00-Z13 Persons encountering health services for examination and investigation	0.593	0.407	0.000
K22 Other diseases of oesophagus	0.587	0.413	0.000
A30-A49 Other bacterial diseases	0.586	0.413	0.000
K80-K87 Disorders of gallbladder, biliary tract and pancreas	0.586	0.414	0.000
R79 Other abnormal findings of blood chemistry	0.581	0.419	0.000
I20.9 Angina pectoris, unspecified	0.579	0.421	0.000
G56 Mononeuropathies of upper limb	0.579	0.421	0.000
E14 Unspecified diabetes mellitus	0.577	0.423	0.000
E13 Other specified diabetes mellitus	0.577	0.423	0.000
E12 Malnutrition-related diabetes mellitus	0.577	0.423	0.000
E10 Insulin-dependent diabetes mellitus	0.577	0.423	0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit	0.577	0.423	0.000
K28 Gastrojejunal ulcer	0.573	0.427	0.000
K27 Peptic ulcer, site unspecified	0.573	0.427	0.000
K26 Duodenal ulcer	0.573	0.427	0.000
K23 Disorders of oesophagus in diseases classified elsewhere	0.573	0.427	0.000
I24 Other acute ischaemic heart diseases	0.568	0.432	0.000
I23 Certain current complications following acute myocardial infarction	0.568	0.432	0.000
I22 Subsequent myocardial infarction	0.568	0.432	0.000
K21.0 Gastro-oesophageal reflux disease with oesophagitis	0.566	0.434	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.566	0.434	0.000
E88 Other metabolic disorders	0.566	0.434	0.000
E87 Other disorders of fluid, electrolyte and acid-base balance	0.566	0.434	0.000
E85 Amyloidosis	0.566	0.434	0.000
E84 Cystic fibrosis	0.566	0.434	0.000
E83 Disorders of mineral metabolism	0.566	0.434	0.000
E80 Disorders of porphyrin and bilirubin metabolism	0.566	0.434	0.000
E79 Disorders of purine and pyrimidine metabolism	0.566	0.434	0.000
E77 Disorders of glycoprotein metabolism	0.566	0.434	0.000
E76 Disorders of glycosaminoglycan metabolism	0.566	0.434	0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.566	0.434	0.000
E74 Other disorders of carbohydrate metabolism	0.566	0.434	0.000
E73 Lactose intolerance	0.566	0.434	0.000
E72 Other disorders of amino-acid metabolism	0.566	0.434	0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.566	0.434	0.000
E70 Disorders of aromatic amino-acid metabolism	0.566	0.434	0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.566	0.434	0.000
E86 Volume depletion	0.566	0.434	0.000
R06 Abnormalities of breathing	0.565	0.434	0.000
K20 Oesophagitis	0.565	0.434	0.000
G90-G99 Other disorders of the nervous system	0.563	0.437	0.000
G80-G83 Cerebral palsy and other paralytic syndromes	0.563	0.437	0.000
G70-G73 Diseases of myoneural junction and muscle	0.563	0.437	0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.563	0.437	0.000
G35-G37 Demyelinating diseases of the central nervous system	0.563	0.437	0.000
G30-G32 Other degenerative diseases of the nervous system	0.563	0.437	0.000
G20-G26 Extrapyramidal and movement disorders	0.563	0.437	0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.563	0.437	0.000
G00-G09 Inflammatory diseases of the central nervous system	0.563	0.437	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.558	0.442	0.000
N40 Hyperplasia of prostate	0.555	0.445	0.000
Z70-Z76 Persons encountering health services in other circumstances	0.554	0.446	0.000
D70-D77 Other diseases of blood and blood-forming organs	0.553	0.447	0.000
K57 Diverticular disease of intestine	0.550	0.450	0.000
R03.0 Elevated blood-pressure reading, without diagnosis of hypertension	0.548	0.452	0.000
R07.1 Chest pain on breathing	0.545	0.455	0.000
R07.0 Pain in throat	0.545	0.455	0.000
R07.2 Precordial pain	0.545	0.455	0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.544	0.456	0.000
J40-J47 Chronic lower respiratory diseases	0.544	0.456	0.000
O60-O75 Complications of labour and delivery	0.542	0.458	0.000
Z95 Presence of cardiac and vascular implants and grafts	0.542	0.458	0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances	0.542	0.458	0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases	0.542	0.458	0.000
E11.8 With unspecified complications	0.540	0.460	0.000
E11.7 With multiple complications	0.540	0.460	0.000
E11.6 With other specified complications	0.540	0.460	0.000
E11.5 With peripheral circulatory complications	0.540	0.460	0.000
E11.4 With neurological complications	0.540	0.460	0.000
E11.3 With ophthalmic complications	0.540	0.460	0.000
E11.2 With renal complications	0.540	0.460	0.000
E11.1 With ketoacidosis	0.540	0.460	0.000
E11.0 With coma	0.540	0.460	0.000
I25.1 Atherosclerotic heart disease	0.539	0.461	0.000
D60-D64 Aplastic and other anaemias	0.534	0.465	0.000
L60-L75 Disorders of skin appendages	0.534	0.466	0.000
N47 Redundant prepuce, phimosis and paraphimosis	0.531	0.469	0.000
K31 Other diseases of stomach and duodenum	0.530	0.470	0.000
N99-N99 Other disorders of the genitourinary system	0.529	0.471	0.000
N70-N77 Inflammatory diseases of female pelvic organs	0.529	0.471	0.000
N60-N64 Disorders of breast	0.529	0.471	0.000
N25-N29 Other disorders of kidney and ureter	0.529	0.471	0.000
N20-N23 Urolithiasis	0.529	0.471	0.000
N10-N16 Renal tubulo-interstitial diseases	0.529	0.471	0.000
N00-N08 Glomerular diseases	0.529	0.471	0.000
N50 Other disorders of male genital organs	0.528	0.471	0.000
O94-O99 Other obstetric conditions, not elsewhere classified	0.527	0.473	0.000
O85-O92 Complications predominantly related to the puerperium	0.527	0.473	0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.527	0.473	0.000
O20-O29 Other maternal disorders predominantly related to pregnancy	0.527	0.473	0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.527	0.473	0.000
O00-O08 Pregnancy with abortive outcome	0.527	0.473	0.000
K51 Ulcerative colitis	0.525	0.475	0.000
I20.8 Other forms of angina pectoris	0.522	0.478	0.000
I20.1 Angina pectoris with documented spasm	0.522	0.478	0.000
E78.9 Disorder of lipoprotein metabolism, unspecified	0.521	0.479	0.000
E78.8 Other disorders of lipoprotein metabolism	0.521	0.479	0.000
E78.6 Lipoprotein deficiency	0.521	0.479	0.000
E78.5 Hyperlipidaemia, unspecified	0.521	0.479	0.000
E78.4 Other hyperlipidaemia	0.521	0.479	0.000
E78.3 Hyperchylomicronaemia	0.521	0.479	0.000
E78.2 Mixed hyperlipidaemia	0.521	0.479	0.000
E78.1 Pure hyperglyceridaemia	0.521	0.479	0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use	0.520	0.479	0.000
N17-N19 Renal failure	0.520	0.480	0.000
E66.9 Obesity, unspecified	0.520	0.480	0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere	0.519	0.481	0.000
R31 Unspecified haematuria	0.517	0.483	0.000
R39 Other symptoms and signs involving the urinary system	0.515	0.485	0.000
K59 Other functional intestinal disorders	0.515	0.485	0.000
E67 Other hyperalimentation	0.514	0.486	0.000
E68 Sequelae of hyperalimentation	0.514	0.486	0.000
E65 Localised adiposity	0.514	0.486	0.000
R10-R19 Symptoms and signs involving the digestive system and abdomen	0.513	0.487	0.000
O80 Single spontaneous delivery	0.513	0.487	0.000
L80-L99 Other disorders of the skin and subcutaneous tissue	0.511	0.489	0.000
G56.0 Carpal tunnel syndrome	0.510	0.490	0.000
B99-B99 Other infectious diseases	0.510	0.490	0.000
B90-B94 Sequelae of infectious and parasitic diseases	0.510	0.490	0.000
B85-B89 Pediculosis, acariasis and other infestations	0.510	0.490	0.000
B65-B83 Helminthiases	0.510	0.490	0.000
B50-B64 Protozoal diseases	0.510	0.490	0.000
B35-B49 Mycoses	0.510	0.490	0.000
B25-B34 Other viral diseases	0.510	0.490	0.000
B20-B24 Human immunodeficiency virus [HIV] disease	0.510	0.490	0.000
B15-B19 Viral hepatitis	0.510	0.490	0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions	0.510	0.490	0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers	0.510	0.490	0.000
A80-A89 Viral infections of the central nervous system	0.510	0.490	0.000
A75-A79 Rickettsioses	0.510	0.490	0.000
A70-A74 Other diseases caused by chlamydiae	0.510	0.490	0.000
A65-A69 Other spirochaetal diseases	0.510	0.490	0.000
A50-A64 Infections with a predominantly sexual mode of transmission	0.510	0.490	0.000
A20-A28 Certain zoonotic bacterial diseases	0.510	0.490	0.000
A15-A19 Tuberculosis	0.510	0.490	0.000
N80-N98 Noninflammatory disorders of female genital tract	0.509	0.490	0.000
H55-H59 Other disorders of eye and adnexa	0.508	0.492	0.000
H53-H54 Visual disturbances and blindness	0.508	0.492	0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction	0.508	0.492	0.000
H46-H48 Disorders of optic nerve and visual pathways	0.508	0.492	0.000
H43-H45 Disorders of vitreous body and globe	0.508	0.492	0.000
H40-H42 Glaucoma	0.508	0.492	0.000
H30-H36 Disorders of choroid and retina	0.508	0.492	0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.508	0.492	0.000
H10-H13 Disorders of conjunctiva	0.508	0.492	0.000
F30-F39 Mood [affective] disorders	0.507	0.492	0.000
R69 Unknown and unspecified causes of morbidity	0.505	0.495	0.000
R07.3 Other chest pain	0.504	0.495	0.000
Z88 Personal history of allergy to drugs, medicaments and biologocal substances	0.504	0.496	0.000
Chapter II Neoplasms	0.503	0.496	0.001
R35 Polyuria	0.503	0.497	0.000
J09-J18 Influenza and pneumonia	0.503	0.497	0.000
I25.9 Chronic ischaemic heart disease, unspecified	0.503	0.497	0.000
J20-J22 Other acute lower respiratory infections	0.503	0.497	0.000
R78 Findings of drugs and other substances, not normally found in blood	0.502	0.498	0.000
R77 Other abnormalities of plasma proteins	0.502	0.498	0.000
R76 Other abnormal immunological findings in serum	0.502	0.498	0.000
R74 Abnormal serum enzyme levels	0.502	0.498	0.000
R73 Elevated blood glucose level	0.502	0.498	0.000
R70 Elevated erythrocyte sedimentation rate and abnormality of plasma viscosity	0.502	0.498	0.000
R75 Laboratory evidence of human immunodeficiency virus [HIV]	0.502	0.498	0.000
R72 Abnormality of white blood cells, not elsewhere classified	0.502	0.498	0.000
R71 Abnormality of red blood cells	0.502	0.498	0.000
R63 Symptoms and signs concerning food and fluid intake	0.502	0.498	0.000
D80-D89 Certain disorders involving the immune mechanism	0.501	0.499	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.501	0.499	0.000
D55-D59 Haemolytic anaemias	0.501	0.499	0.000
A00-A09 Intestinal infectious diseases	0.500	0.499	0.000
H25-H28 Disorders of lens	0.500	0.500	0.000
B95-B98 Bacterial, viral and other infectious agents	0.499	0.500	0.000
R53 Malaise and fatigue	0.499	0.501	0.000
K01 Embedded and impacted teeth	0.499	0.501	0.000
J95-J99 Other diseases of the respiratory system	0.499	0.501	0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract	0.499	0.501	0.000
J80-J84 Other respiratory diseases principally affecting the interstitium	0.499	0.501	0.000
J60-J70 Lung diseases due to external agents	0.499	0.501	0.000
J30-J39 Other diseases of upper respiratory tract	0.499	0.501	0.000
J00-J06 Acute upper respiratory infections	0.499	0.501	0.000
I73 Other peripheral vascular diseases	0.498	0.502	0.000
R00.2 Palpitations	0.498	0.502	0.000
Z08 Follow-up examination after treatment for malignant neoplasm	0.498	0.502	0.000
A41 Other septicaemia	0.497	0.503	0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.496	0.504	0.000
L50-L54 Urticaria and erythema	0.496	0.504	0.000
L40-L45 Papulosquamous disorders	0.496	0.504	0.000
L20-L30 Dermatitis and eczema	0.496	0.504	0.000
L10-L14 Bullous disorders	0.496	0.504	0.000
R79.8 Other specified abnormal findings of blood chemistry	0.496	0.504	0.000
J90-J94 Other diseases of pleura	0.495	0.504	0.000
I10-I15 Hypertensive diseases	0.492	0.508	0.000
I25.8 Other forms of chronic ischaemic heart disease	0.492	0.508	0.000
L00-L08 Infections of the skin and subcutaneous tissue	0.490	0.510	0.000
Z40-Z54 Persons encountering health services for specific procedures and health care	0.489	0.511	0.000
F99-F99 Unspecified mental disorder	0.488	0.512	0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.488	0.512	0.000
F80-F89 Disorders of psychological development	0.488	0.512	0.000
F70-F79 Mental retardation	0.488	0.512	0.000
F60-F69 Disorders of adult personality and behaviour	0.488	0.512	0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.488	0.512	0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.488	0.512	0.000
F00-F09 Organic, including symptomatic, mental disorders	0.488	0.512	0.000
I21.9 Acute myocardial infarction, unspecified	0.486	0.513	0.000
G59 Mononeuropathy in diseases classified elsewhere	0.484	0.516	0.000
G58 Other mononeuropathies	0.484	0.516	0.000
G57 Mononeuropathies of lower limb	0.484	0.516	0.000
G54 Nerve root and plexus disorders	0.484	0.516	0.000
G53 Cranial nerve disorders in diseases classified elsewhere	0.484	0.516	0.000
G52 Disorders of other cranial nerves	0.484	0.516	0.000
G51 Facial nerve disorders	0.484	0.516	0.000
G50 Disorders of trigeminal nerve	0.484	0.516	0.000
H00 Hordeolum and chalazion	0.482	0.518	0.000
I25.2 Old myocardial infarction	0.481	0.519	0.000
R55 Syncope and collapse	0.478	0.522	0.000
R03.1 Nonspecific low blood-pressure reading	0.477	0.523	0.000
R30 Pain associated with micturition	0.476	0.523	0.000
R36 Urethral discharge	0.476	0.523	0.000
R34 Anuria and oliguria	0.476	0.523	0.000
R32 Unspecified urinary incontinence	0.476	0.523	0.000
K52 Other non-infective gastro-enteritis and colitis	0.476	0.524	0.000
I95 Hypotension	0.476	0.524	0.000
K50 Crohn's disease [regional enteritis]	0.475	0.525	0.000
I25.6 Silent myocardial ischaemia	0.475	0.525	0.000
I25.5 Ischaemic cardiomyopathy	0.475	0.525	0.000
I25.4 Coronary artery aneurysm	0.475	0.525	0.000
I25.3 Aneurysm of heart	0.475	0.525	0.000
I25.0 Atherosclerotic cardiovascular disease, so described	0.475	0.525	0.000
N51 Disorders of male genital organs in diseases classified elsewhere	0.475	0.525	0.000
N49 Inflammatory disorders of male genital organs, not elsewhere classified	0.475	0.525	0.000
N48 Other disorders of penis	0.475	0.525	0.000
N45 Orchitis and epididymitis	0.475	0.525	0.000
N43 Hydrocele and spermatocele	0.475	0.525	0.000
N42 Other disorders of prostate	0.475	0.525	0.000
N41 Inflammatory diseases of prostate	0.475	0.525	0.000
N46 Male infertility	0.475	0.525	0.000
N44 Torsion of testis	0.475	0.525	0.000
G47 Sleep disorders	0.474	0.526	0.000
R68 Other general symptoms and signs	0.474	0.526	0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]	0.474	0.526	0.000
R62 Lack of expected normal physiological development	0.474	0.526	0.000
R61 Hyperhidrosis	0.474	0.526	0.000
R60 Oedema, not elsewhere classified	0.474	0.526	0.000
R59 Enlarged lymph nodes	0.474	0.526	0.000
R57 Shock, not elsewhere classified	0.474	0.526	0.000
R56 Convulsions, not elsewhere classified	0.474	0.526	0.000
R52 Pain, not elsewhere classified	0.474	0.526	0.000
R64 Cachexia	0.474	0.526	0.000
R58 Haemorrhage, not elsewhere classified	0.474	0.526	0.000
R54 Senility	0.474	0.526	0.000
R50 Fever of unknown origin	0.471	0.528	0.000
H90-H95 Other disorders of ear	0.471	0.529	0.000
I34 Nonrheumatic mitral valve disorders	0.470	0.530	0.000
Z37 Outcome of delivery	0.468	0.532	0.000
F40-F48 Neurotic, stress-related and somatoform disorders	0.467	0.533	0.000
H80-H83 Diseases of inner ear	0.467	0.533	0.000
H65-H75 Diseases of middle ear and mastoid	0.467	0.533	0.000
H60-H62 Diseases of external ear	0.467	0.533	0.000
G43 Migraine	0.466	0.534	0.000
K66 Other disorders of peritoneum	0.465	0.534	0.000
K25.9 Unspecified as acute or chronic, without haemorrhage or perforation	0.464	0.536	0.000
K14 Diseases of tongue	0.464	0.536	0.000
K13 Other diseases of lip and oral mucosa	0.464	0.536	0.000
K12 Stomatitis and related lesions	0.464	0.536	0.000
K11 Diseases of salivary glands	0.464	0.536	0.000
K10 Other diseases of jaws	0.464	0.536	0.000
K09 Cysts of oral region, not elsewhere classified	0.464	0.536	0.000
K08 Other disorders of teeth and supporting structures	0.464	0.536	0.000
K07 Dentofacial anomalies [including malocclusion]	0.464	0.536	0.000
K06 Other disorders of gingiva and edentulous alveolar ridge	0.464	0.536	0.000
K05 Gingivitis and periodontal diseases	0.464	0.536	0.000
K04 Diseases of pulp and periapical tissues	0.464	0.536	0.000
K03 Other diseases of hard tissues of teeth	0.464	0.536	0.000
K02 Dental caries	0.464	0.536	0.000
K00 Disorders of tooth development and eruption	0.464	0.536	0.000
Z92 Personal history of medical treatment	0.464	0.536	0.000
P90-P96 Other disorders originating in the perinatal period	0.463	0.536	0.000
P80-P83 Conditions involving the integument and temperature regulation of fetus and newborn	0.463	0.536	0.000
P75-P78 Digestive system disorders of fetus and newborn	0.463	0.536	0.000
P70-P74 Transitory endocrine and metabolic disorders specific to fetus and newborn	0.463	0.536	0.000
P50-P61 Haemorrhagic and haematological disorders of fetus and newborn	0.463	0.536	0.000
P35-P39 Infections specific to the perinatal period	0.463	0.536	0.000
P20-P29 Respiratory and cardiovascular disorders specific to the perinatal period	0.463	0.536	0.000
P10-P15 Birth trauma	0.463	0.536	0.000
P05-P08 Disorders related to length of gestation and fetal growth	0.463	0.536	0.000
P00-P04 Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery	0.463	0.536	0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.463	0.536	0.000
Q80-Q89 Other congenital malformations	0.463	0.536	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.463	0.536	0.000
Q60-Q64 Congenital malformations of the urinary system	0.463	0.536	0.000
Q50-Q56 Congenital malformations of genital organs	0.463	0.536	0.000
Q38-Q45 Other congenital malformations of the digestive system	0.463	0.536	0.000
Q35-Q37 Cleft lip and cleft palate	0.463	0.536	0.000
Q30-Q34 Congenital malformations of the respiratory system	0.463	0.536	0.000
Q20-Q28 Congenital malformations of the circulatory system	0.463	0.536	0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.463	0.536	0.000
Q00-Q07 Congenital malformations of the nervous system	0.463	0.536	0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs	0.463	0.536	0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use	0.463	0.536	0.000
D50-D53 Nutritional anaemias	0.463	0.536	0.000
R04.0 Epistaxis	0.462	0.537	0.000
K57.3 Diverticular disease of large intestine without perforation or abscess	0.461	0.539	0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.458	0.542	0.000
I78 Diseases of capillaries	0.458	0.542	0.000
I77 Other disorders of arteries and arterioles	0.458	0.542	0.000
I74 Arterial embolism and thrombosis	0.458	0.542	0.000
I72 Other aneurysm	0.458	0.542	0.000
I71 Aortic aneurysm and dissection	0.458	0.542	0.000
I70 Atherosclerosis	0.458	0.542	0.000
K92 Other diseases of digestive system	0.458	0.542	0.000
K64 Haemorrhoids and perianal venous thrombosis	0.457	0.542	0.000
K61 Abscess of anal and rectal regions	0.457	0.542	0.000
K60 Fissure and fistula of anal and rectal regions	0.457	0.542	0.000
K56 Paralytic ileus and intestinal obstruction without hernia	0.457	0.542	0.000
K55 Vascular disorders of intestine	0.457	0.542	0.000
Z82 Family history of certain disabilities and chronic diseases leading to disablement	0.457	0.542	0.000
R00.8 Other and unspecified abnormalities of heart beat	0.456	0.544	0.000
R00.1 Bradycardia, unspecified	0.456	0.544	0.000
R00.0 Tachycardia, unspecified	0.456	0.544	0.000
Z91 Personal history of risk-factors, not elsewhere classified	0.455	0.545	0.000
Z95.5 Presence of coronary angioplasty implant and graft	0.454	0.546	0.000
Z98 Other postsurgical states	0.452	0.548	0.000
E16 Other disorders of pancreatic internal secretion	0.450	0.549	0.000
E15 Nondiabetic hypoglycaemic coma	0.450	0.549	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.450	0.549	0.000
E34 Other endocrine disorders	0.450	0.549	0.000
E32 Diseases of thymus	0.450	0.549	0.000
E31 Polyglandular dysfunction	0.450	0.549	0.000
E30 Disorders of puberty, not elsewhere classified	0.450	0.549	0.000
E29 Testicular dysfunction	0.450	0.549	0.000
E28 Ovarian dysfunction	0.450	0.549	0.000
E27 Other disorders of adrenal gland	0.450	0.549	0.000
E26 Hyperaldosteronism	0.450	0.549	0.000
E25 Adrenogenital disorders	0.450	0.549	0.000
E24 Cushing's syndrome	0.450	0.549	0.000
E23 Hypofunction and other disorders of pituitary gland	0.450	0.549	0.000
E22 Hyperfunction of pituitary gland	0.450	0.549	0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.450	0.549	0.000
E20 Hypoparathyroidism	0.450	0.549	0.000
E44 Protein-energy malnutrition of moderate and mild degree	0.450	0.549	0.000
E46 Unspecified protein-energy malnutrition	0.450	0.549	0.000
E45 Retarded development following protein-energy malnutrition	0.450	0.549	0.000
E43 Unspecified severe protein-energy malnutrition	0.450	0.549	0.000
E42 Marasmic kwashiorkor	0.450	0.549	0.000
E41 Nutritional marasmus	0.450	0.549	0.000
E40 Kwashiorkor	0.450	0.549	0.000
E64 Sequelae of malnutrition and other nutritional deficiencies	0.450	0.549	0.000
E63 Other nutritional deficiencies	0.450	0.549	0.000
E61 Deficiency of other nutrient elements	0.450	0.549	0.000
E56 Other vitamin deficiencies	0.450	0.549	0.000
E55 Vitamin D deficiency	0.450	0.549	0.000
E53 Deficiency of other B group vitamins	0.450	0.549	0.000
E51 Thiamine deficiency	0.450	0.549	0.000
E50 Vitamin A deficiency	0.450	0.549	0.000
E60 Dietary zinc deficiency	0.450	0.549	0.000
E59 Dietary selenium deficiency	0.450	0.549	0.000
E58 Dietary calcium deficiency	0.450	0.549	0.000
E54 Ascorbic acid deficiency	0.450	0.549	0.000
E52 Niacin deficiency [pellagra]	0.450	0.549	0.000
Z95.8 Presence of other cardiac and vascular implants and grafts	0.450	0.550	0.000
K67 Disorders of peritoneum in infectious diseases classified elsewhere	0.450	0.550	0.000
K65 Peritonitis	0.450	0.550	0.000
R94 Abnormal results of function studies	0.449	0.550	0.000
N30-N39 Other diseases of urinary system	0.449	0.551	0.000
I98 Other disorders of circulatory system in diseases classified elsewhere	0.448	0.551	0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified	0.448	0.551	0.000
I99 Other and unspecified disorders of circulatory system	0.448	0.551	0.000
D70 Agranulocytosis	0.448	0.552	0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.447	0.552	0.000
T79-T79 Certain early complications of trauma	0.447	0.552	0.000
T66-T78 Other and unspecified effects of external causes	0.447	0.552	0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.447	0.552	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.447	0.552	0.000
T33-T35 Frostbite	0.447	0.552	0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.447	0.552	0.000
T26-T28 Burns and corrosions confined to eye and internal organs	0.447	0.552	0.000
T20-T25 Burns and corrosions of external body surface, specified by site	0.447	0.552	0.000
T15-T19 Effects of foreign body entering through natural orifice	0.447	0.552	0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.447	0.552	0.000
T00-T07 Injuries involving multiple body regions	0.447	0.552	0.000
S90-S99 Injuries to the ankle and foot	0.447	0.552	0.000
S80-S89 Injuries to the knee and lower leg	0.447	0.552	0.000
S70-S79 Injuries to the hip and thigh	0.447	0.552	0.000
S60-S69 Injuries to the wrist and hand	0.447	0.552	0.000
S50-S59 Injuries to the elbow and forearm	0.447	0.552	0.000
S40-S49 Injuries to the shoulder and upper arm	0.447	0.552	0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.447	0.552	0.000
S20-S29 Injuries to the thorax	0.447	0.552	0.000
S10-S19 Injuries to the neck	0.447	0.552	0.000
S00-S09 Injuries to the head	0.447	0.552	0.000
R93 Abnormal findings on diagnostic imaging of other body structures	0.447	0.553	0.000
R90 Abnormal findings on diagnostic imaging of central nervous system	0.447	0.553	0.000
R92 Abnormal findings on diagnostic imaging of breast	0.447	0.553	0.000
R91 Abnormal findings on diagnostic imaging of lung	0.447	0.553	0.000
K93 Disorders of other digestive organs in diseases classified elsewhere	0.447	0.553	0.000
K91 Postprocedural disorders of digestive system, not elsewhere classified	0.447	0.553	0.000
K90 Intestinal malabsorption	0.447	0.553	0.000
O80.0 Spontaneous vertex delivery	0.447	0.553	0.000
I52 Other heart disorders in diseases classified elsewhere	0.446	0.554	0.000
I51 Complications and ill-defined descriptions of heart disease	0.446	0.554	0.000
I50 Heart failure	0.446	0.554	0.000
I49 Other cardiac arrhythmias	0.446	0.554	0.000
I48 Atrial fibrillation and flutter	0.446	0.554	0.000
I47 Paroxysmal tachycardia	0.446	0.554	0.000
I46 Cardiac arrest	0.446	0.554	0.000
I45 Other conduction disorders	0.446	0.554	0.000
I44 Atrioventricular and left bundle-branch block	0.446	0.554	0.000
I43 Cardiomyopathy in diseases classified elsewhere	0.446	0.554	0.000
I42 Cardiomyopathy	0.446	0.554	0.000
I41 Myocarditis in diseases classified elsewhere	0.446	0.554	0.000
I40 Acute myocarditis	0.446	0.554	0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.446	0.554	0.000
I37 Pulmonary valve disorders	0.446	0.554	0.000
I36 Nonrheumatic tricuspid valve disorders	0.446	0.554	0.000
I35 Nonrheumatic aortic valve disorders	0.446	0.554	0.000
I33 Acute and subacute endocarditis	0.446	0.554	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations