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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3131283
log Bayes Factor = 148.813
Chromosome 6   position 32,119,898  (GRCh37) Explore rs3131283 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
I10 Essential (primary) hypertension
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
Chapter IX Diseases of the circulatory system
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
# Top node
0.000 0.000 1.000
L40 Psoriasis
0.000 0.000 1.000
I10-I15 Hypertensive diseases
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
Chapter XI Diseases of the digestive system
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
L40-L45 Papulosquamous disorders
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.001 0.999
M05-M14 Inflammatory polyarthropathies
0.000 0.001 0.999
E83.1 Disorders of iron metabolism
0.999 0.001 0.000
E16 Other disorders of pancreatic internal secretion
0.000 0.001 0.999
L40.9 Psoriasis, unspecified
0.000 0.001 0.999
G35-G37 Demyelinating diseases of the central nervous system
0.999 0.001 0.000
E16.2 Hypoglycaemia, unspecified
0.000 0.001 0.999
H36 Retinal disorders in diseases classified elsewhere
0.000 0.001 0.999
I20 Angina pectoris
0.000 0.002 0.998
K90 Intestinal malabsorption
0.000 0.002 0.998
K90-K93 Other diseases of the digestive system
0.000 0.002 0.998
G37 Other demyelinating diseases of central nervous system
0.998 0.002 0.000
H30-H36 Disorders of choroid and retina
0.000 0.002 0.998
L43 Lichen planus
0.000 0.002 0.998
Chapter VII Diseases of the eye and adnexa
0.000 0.003 0.997
E10.4 With neurological complications
0.000 0.003 0.997
L43.9 Lichen planus, unspecified
0.000 0.004 0.996
G37.9 Demyelinating disease of central nervous system, unspecified
0.995 0.005 0.000
E14.9 Without complications
0.000 0.005 0.995
I22 Subsequent myocardial infarction
0.000 0.006 0.994
M05 Seropositive rheumatoid arthritis
0.000 0.008 0.992
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.008 0.992
I20.0 Unstable angina
0.000 0.010 0.990
I30-I52 Other forms of heart disease
0.000 0.010 0.990
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.011 0.989
E14.3 With ophthalmic complications
0.000 0.012 0.988
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.013 0.987
K51.9 Ulcerative colitis, unspecified
0.987 0.013 0.000
E70-E90 Metabolic disorders
0.000 0.013 0.987
K51 Ulcerative colitis
0.987 0.013 0.000
I47 Paroxysmal tachycardia
0.000 0.014 0.986
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.014 0.986
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.015 0.985
J45.9 Asthma, unspecified
0.000 0.015 0.985
H43-H45 Disorders of vitreous body and globe
0.000 0.015 0.985
K70-K77 Diseases of liver
0.000 0.019 0.981
H43 Disorders of vitreous body
0.000 0.019 0.981
I25.1 Atherosclerotic heart disease
0.000 0.020 0.980
I35 Nonrheumatic aortic valve disorders
0.000 0.022 0.978
K80-K87 Disorders of gallbladder, biliary tract and pancreas
0.000 0.022 0.978
I35.0 Aortic (valve) stenosis
0.000 0.023 0.977
I47.1 Supraventricular tachycardia
0.000 0.024 0.976
K51.3 Ulcerative (chronic) rectosigmoiditis
0.976 0.024 0.000
I24 Other acute ischaemic heart diseases
0.000 0.027 0.973
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.029 0.971
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.031 0.969
I20.9 Angina pectoris, unspecified
0.000 0.032 0.968
K74 Fibrosis and cirrhosis of liver
0.000 0.038 0.962
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.039 0.961
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.040 0.960
E10.5 With peripheral circulatory complications
0.000 0.040 0.960
E11.3 With ophthalmic complications
0.000 0.041 0.959
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.049 0.951
K82 Other diseases of gallbladder
0.000 0.049 0.951
K74.3 Primary biliary cirrhosis
0.000 0.053 0.947
H43.3 Other vitreous opacities
0.000 0.053 0.947
H43.8 Other disorders of vitreous body
0.000 0.054 0.946
K55-K64 Other diseases of intestines
0.000 0.058 0.942
K50-K52 Noninfective enteritis and colitis
0.014 0.060 0.926
I25.5 Ischaemic cardiomyopathy
0.000 0.063 0.937
H34 Retinal vascular occlusions
0.000 0.064 0.936
I12 Hypertensive renal disease
0.000 0.066 0.934
K60 Fissure and fistula of anal and rectal regions
0.000 0.066 0.934
M07 Psoriatic and enteropathic arthropathies
0.000 0.066 0.933
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.067 0.933
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.074 0.926
K82.8 Other specified diseases of gallbladder
0.000 0.074 0.926
K80.2 Calculus of gallbladder without cholecystitis
0.000 0.078 0.922
K81 Cholecystitis
0.000 0.079 0.921
K60.2 Anal fissure, unspecified
0.000 0.079 0.921
K80 Cholelithiasis
0.000 0.079 0.921
E11.1 With ketoacidosis
0.000 0.087 0.913
K51.8 Other ulcerative colitis
0.911 0.089 0.000
E07 Other disorders of thyroid
0.000 0.091 0.909
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.092 0.908
I31 Other diseases of pericardium
0.000 0.092 0.908
I21 Acute myocardial infarction
0.000 0.097 0.903
I15 Secondary hypertension
0.000 0.100 0.900
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.105 0.895
H40-H42 Glaucoma
0.000 0.106 0.894
G37.8 Other specified demyelinating diseases of central nervous system
0.893 0.107 0.000
E11.5 With peripheral circulatory complications
0.000 0.107 0.893
E13 Other specified diabetes mellitus
0.000 0.109 0.891
E11.2 With renal complications
0.000 0.111 0.889
I25.2 Old myocardial infarction
0.000 0.112 0.888
M07.3 Other psoriatic arthropathies
0.000 0.114 0.886
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.115 0.885
E10.2 With renal complications
0.000 0.115 0.885
K72 Hepatic failure, not elsewhere classified
0.000 0.115 0.885
J45 Asthma
0.000 0.117 0.883
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.120 0.880
K50 Crohn's disease [regional enteritis]
0.001 0.121 0.879
I20.1 Angina pectoris with documented spasm
0.000 0.123 0.877
K55 Vascular disorders of intestine
0.000 0.123 0.877
K81.9 Cholecystitis, unspecified
0.000 0.124 0.876
E05.9 Thyrotoxicosis, unspecified
0.000 0.124 0.876
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.125 0.875
K60.0 Acute anal fissure
0.000 0.132 0.868
K81.1 Chronic cholecystitis
0.000 0.133 0.867
I47.2 Ventricular tachycardia
0.000 0.134 0.866
H34.2 Other retinal artery occlusions
0.000 0.137 0.863
I12.9 Hypertensive renal disease without renal failure
0.000 0.137 0.863
E07.9 Disorder of thyroid, unspecified
0.000 0.141 0.859
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.143 0.857
J40-J47 Chronic lower respiratory diseases
0.000 0.144 0.856
K63 Other diseases of intestine
0.000 0.146 0.854
E03.8 Other specified hypothyroidism
0.000 0.148 0.852
Chapter X Diseases of the respiratory system
0.000 0.149 0.851
M06.3 Rheumatoid nodule
0.000 0.150 0.849
I31.3 Pericardial effusion (noninflammatory)
0.000 0.155 0.845
K82.1 Hydrops of gallbladder
0.000 0.155 0.845
I46 Cardiac arrest
0.000 0.158 0.842
M06.4 Inflammatory polyarthropathy
0.000 0.159 0.841
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.164 0.836
K58 Irritable bowel syndrome
0.000 0.169 0.831
K51.2 Ulcerative (chronic) proctitis
0.825 0.175 0.000
K55.2 Angiodysplasia of colon
0.000 0.176 0.824
Chapter VI Diseases of the nervous system
0.821 0.176 0.003
H40 Glaucoma
0.000 0.181 0.819
H40.9 Glaucoma, unspecified
0.000 0.182 0.818
K73 Chronic hepatitis, not elsewhere classified
0.000 0.182 0.818
I21.9 Acute myocardial infarction, unspecified
0.000 0.182 0.818
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.183 0.817
K51.5 Mucosal proctocolitis
0.816 0.184 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.185 0.815
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.185 0.815
E13.9 Without complications
0.000 0.187 0.813
K75 Other inflammatory liver diseases
0.000 0.188 0.812
K63.9 Disease of intestine, unspecified
0.000 0.193 0.807
I15.1 Hypertension secondary to other renal disorders
0.000 0.193 0.807
M65-M68 Disorders of synovium and tendon
0.000 0.193 0.807
G80-G83 Cerebral palsy and other paralytic syndromes
0.806 0.194 0.001
E16.1 Other hypoglycaemia
0.000 0.199 0.801
K60.5 Anorectal fistula
0.000 0.199 0.801
I44 Atrioventricular and left bundle-branch block
0.000 0.200 0.800
E06 Thyroiditis
0.000 0.200 0.799
I25.3 Aneurysm of heart
0.000 0.201 0.799
E11.0 With coma
0.000 0.202 0.798
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.202 0.798
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.000 0.207 0.793
E40-E46 Malnutrition
0.000 0.208 0.792
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.209 0.791
L43.8 Other lichen planus
0.000 0.210 0.790
K58.0 Irritable bowel syndrome with diarrhoea
0.000 0.211 0.789
E74 Other disorders of carbohydrate metabolism
0.000 0.214 0.786
M45-M49 Spondylopathies
0.000 0.216 0.784
K72.9 Hepatic failure, unspecified
0.000 0.217 0.783
K55.8 Other vascular disorders of intestine
0.000 0.218 0.782
G81 Hemiplegia
0.780 0.220 0.000
I47.9 Paroxysmal tachycardia, unspecified
0.000 0.220 0.780
L40.8 Other psoriasis
0.000 0.222 0.778
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.778 0.222 0.000
I21.4 Acute subendocardial myocardial infarction
0.000 0.223 0.777
I46.9 Cardiac arrest, unspecified
0.000 0.224 0.776
E83 Disorders of mineral metabolism
0.706 0.224 0.070
I47.0 Reentry ventricular arrhythmia
0.000 0.227 0.773
K50.9 Crohn's disease, unspecified
0.000 0.229 0.771
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.229 0.771
H43.9 Disorder of vitreous body, unspecified
0.000 0.231 0.769
E11.6 With other specified complications
0.000 0.231 0.769
I51 Complications and ill-defined descriptions of heart disease
0.000 0.232 0.768
Chapter VIII Diseases of the ear and mastoid process
0.000 0.232 0.767
M45 Ankylosing spondylitis
0.000 0.233 0.766
K51.4 Pseudopolyposis of colon
0.766 0.234 0.000
K50.8 Other Crohn's disease
0.000 0.235 0.765
G81.9 Hemiplegia, unspecified
0.764 0.236 0.000
M70-M79 Other soft tissue disorders
0.000 0.239 0.761
I23 Certain current complications following acute myocardial infarction
0.000 0.240 0.760
I12.0 Hypertensive renal disease with renal failure
0.000 0.240 0.760
K63.3 Ulcer of intestine
0.000 0.241 0.759
G30-G32 Other degenerative diseases of the nervous system
0.757 0.242 0.001
J95-J99 Other diseases of the respiratory system
0.000 0.243 0.757
H34.8 Other retinal vascular occlusions
0.000 0.246 0.754
J46 Status asthmaticus
0.000 0.248 0.752
M11 Other crystal arthropathies
0.000 0.249 0.751
K74.5 Biliary cirrhosis, unspecified
0.000 0.249 0.751
L40.0 Psoriasis vulgaris
0.000 0.250 0.750
K74.6 Other and unspecified cirrhosis of liver
0.000 0.251 0.749
K51.0 Ulcerative (chronic) enterocolitis
0.744 0.256 0.000
I25.4 Coronary artery aneurysm
0.000 0.256 0.744
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.258 0.742
M65 Synovitis and tenosynovitis
0.000 0.259 0.741
J86 Pyothorax
0.000 0.260 0.739
E78.2 Mixed hyperlipidaemia
0.000 0.261 0.739
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.261 0.739
E11.4 With neurological complications
0.000 0.261 0.739
I51.8 Other ill-defined heart diseases
0.000 0.262 0.738
I44.3 Other and unspecified atrioventricular block
0.000 0.265 0.735
I30 Acute pericarditis
0.000 0.266 0.734
H30 Chorioretinal inflammation
0.000 0.271 0.729
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.272 0.728
E78.1 Pure hyperglyceridaemia
0.000 0.275 0.725
K80.8 Other cholelithiasis
0.000 0.275 0.725
K82.9 Disease of gallbladder, unspecified
0.000 0.276 0.724
K50.0 Crohn's disease of small intestine
0.000 0.278 0.722
G83 Other paralytic syndromes
0.721 0.279 0.000
H43.1 Vitreous haemorrhage
0.000 0.279 0.721
G20-G26 Extrapyramidal and movement disorders
0.720 0.279 0.001
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.000 0.280 0.720
M06.34 Rheumatoid nodule (Hand)
0.000 0.282 0.718
E10.8 With unspecified complications
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E10.6 With other specified complications
0.000 0.283 0.717
E10.0 With coma
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.3 Pustulosis palmaris et plantaris
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
I13 Hypertensive heart and renal disease
0.000 0.283 0.717
I00-I02 Acute rheumatic fever
0.000 0.283 0.717
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.6 With other specified complications
0.000 0.283 0.717
E14.5 With peripheral circulatory complications
0.000 0.283 0.717
E14.4 With neurological complications
0.000 0.283 0.717
E14.2 Withrenal complications
0.000 0.283 0.717
E14.1 With ketoacidosis
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
L44 Other papulosquamous disorders
0.000 0.283 0.717
L41 Parapsoriasis
0.000 0.283 0.717
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.283 0.717
E15 Nondiabetic hypoglycaemic coma
0.000 0.283 0.716
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.716
M08 Juvenile arthritis
0.000 0.283 0.716
G30 Alzheimer's disease
0.716 0.284 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.284 0.716
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.284 0.716
E16.4 Abnormal secretion of gastrin
0.000 0.284 0.716
E16.3 Increased secretion of glucagon
0.000 0.284 0.716
I31.9 Disease of pericardium, unspecified
0.000 0.284 0.716
G36 Other acute disseminated demyelination
0.716 0.284 0.000
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.284 0.716
K90.3 Pancreatic steatorrhoea
0.000 0.284 0.716
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.284 0.716
K90.1 Tropical sprue
0.000 0.284 0.716
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.284 0.715
G37.5 Concentric sclerosis [Balo]
0.715 0.284 0.000
G37.4 Subacute necrotising myelitis
0.715 0.284 0.000
G37.2 Central pontine myelinolysis
0.715 0.284 0.000
G37.1 Central demyelination of corpus callosum
0.715 0.284 0.000
G37.0 Diffuse sclerosis
0.715 0.284 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.285 0.715
L43.3 Subacute (active) lichen planus
0.000 0.285 0.715
L43.2 Lichenoid drug reaction
0.000 0.285 0.715
L43.1 Bullous lichen planus
0.000 0.285 0.715
L43.0 Hypertrophic lichen planus
0.000 0.285 0.715
K72.0 Acute and subacute hepatic failure
0.000 0.285 0.715
M05.8 Other seropositive rheumatoid arthritis
0.000 0.288 0.711
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.288 0.711
M05.2 Rheumatoid vasculitis
0.000 0.288 0.711
M05.1 Rheumatoid lung disease
0.000 0.288 0.711
M05.0 Felty's syndrome
0.000 0.288 0.711
E88 Other metabolic disorders
0.000 0.289 0.711
I52 Other heart disorders in diseases classified elsewhere
0.000 0.290 0.710
I48 Atrial fibrillation and flutter
0.000 0.290 0.710
I41 Myocarditis in diseases classified elsewhere
0.000 0.290 0.710
I40 Acute myocarditis
0.000 0.290 0.710
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.290 0.710
I32 Pericarditis in diseases classified elsewhere
0.000 0.290 0.710
E78.6 Lipoprotein deficiency
0.000 0.291 0.709
E78.3 Hyperchylomicronaemia
0.000 0.291 0.709
I35.8 Other aortic valve disorders
0.000 0.291 0.708
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.292 0.708
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.292 0.708
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.292 0.708
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.292 0.708
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.292 0.708
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.292 0.708
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.292 0.708
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.292 0.708
E77 Disorders of glycoprotein metabolism
0.000 0.292 0.708
E76 Disorders of glycosaminoglycan metabolism
0.000 0.292 0.708
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.292 0.708
E72 Other disorders of amino-acid metabolism
0.000 0.292 0.708
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.292 0.708
E70 Disorders of aromatic amino-acid metabolism
0.000 0.292 0.708
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.292 0.708
M75 Shoulder lesions
0.000 0.294 0.706
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.294 0.706
I05-I09 Chronic rheumatic heart diseases
0.000 0.295 0.705
K77 Liver disorders in diseases classified elsewhere
0.000 0.296 0.703
K71 Toxic liver disease
0.000 0.296 0.703
I15.9 Seconday hypertension, unspecified
0.000 0.297 0.703
H43.2 Crystalline deposits in vitreous body
0.000 0.297 0.703
H43.0 Vitreous prolapse
0.000 0.297 0.703
H34.1 Central retinal artery occlusion
0.000 0.297 0.703
M65.4 Radial styloid tenosynovitis [de Quervain]
0.000 0.297 0.703
H65-H75 Diseases of middle ear and mastoid
0.000 0.299 0.701
K87 Disorders of gallbladder, biliary tract and pancreas in diseases classified elsewhere
0.000 0.299 0.701
K51.1 Ulcerative (chronic) ileocolitis
0.700 0.300 0.000
K52 Other non-infective gastro-enteritis and colitis
0.002 0.300 0.698
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.300 0.700
M75.0 Adhesive capsulitis of shoulder
0.000 0.302 0.698
H60-H62 Diseases of external ear
0.000 0.303 0.697
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.000 0.306 0.693
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.309 0.691
E11.8 With unspecified complications
0.000 0.309 0.691
K74.4 Secondary biliary cirrhosis
0.000 0.310 0.690
K74.2 Hepatic fibrosis with hepatic sclerosis
0.000 0.310 0.690
K74.1 Hepatic sclerosis
0.000 0.310 0.690
E79 Disorders of purine and pyrimidine metabolism
0.000 0.310 0.690
E78.8 Other disorders of lipoprotein metabolism
0.000 0.311 0.689
K82.3 Fistula of gallbladder
0.000 0.311 0.689
K63.4 Enteroptosis
0.000 0.313 0.687
K82.2 Perforation of gallbladder
0.000 0.314 0.686
G20 Parkinson's disease
0.684 0.316 0.000
J44 Other chronic obstructive pulmonary disease
0.000 0.318 0.682
E06.3 Autoimmune thyroiditis
0.000 0.318 0.682
E78.4 Other hyperlipidaemia
0.000 0.318 0.682
K75.4 Autoimmune hepatitis
0.000 0.318 0.682
G30.9 Alzheimer's disease, unspecified
0.680 0.320 0.000
L42 Pityriasis rosea
0.000 0.322 0.677
J43 Emphysema
0.000 0.322 0.678
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.324 0.676
K64 Haemorrhoids and perianal venous thrombosis
0.000 0.325 0.675
H34.9 Retinal vascular occlusion, unspecified
0.000 0.329 0.671
H34.0 Transient retinal artery occlusion
0.000 0.329 0.671
Q60-Q64 Congenital malformations of the urinary system
0.000 0.330 0.670
M07.6 Other enteropathic arthropathies
0.000 0.331 0.669
M07.5 Arthropathy in ulcerative colitis
0.000 0.331 0.669
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.331 0.669
M07.2 Psoriatic spondylitis
0.000 0.331 0.669
M07.1 Arthritis mutilans
0.000 0.331 0.669
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.331 0.669
I11 Hypertensive heart disease
0.000 0.331 0.669
M06.0 Seronegative rheumatoid arthritis
0.000 0.331 0.669
J98 Other respiratory disorders
0.000 0.331 0.669
E83.3 Disorders of phosphorus metabolism
0.648 0.332 0.019
I24.8 Other forms of acute ischaemic heart disease
0.000 0.333 0.667
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.000 0.333 0.667
K73.9 Chronic hepatitis, unspecified
0.000 0.334 0.666
H71 Cholesteatoma of middle ear
0.000 0.335 0.665
M86-M90 Other osteopathies
0.000 0.336 0.664
M14 Arthropathies in other diseases classified elsewhere
0.000 0.338 0.662
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.339 0.661
K63.2 Fistula of intestine
0.000 0.339 0.661
K80.3 Calculus of bile duct with cholangitis
0.000 0.340 0.660
J86.9 Pyothorax without fistula
0.000 0.341 0.659
K90.9 Intestinal malabsorption, unspecified
0.000 0.343 0.657
E84 Cystic fibrosis
0.000 0.344 0.656
K55.1 Chronic vascular disorders of intestine
0.000 0.344 0.656
Q61 Cystic kidney disease
0.000 0.344 0.656
I44.7 Left bundle-branch block, unspecified
0.000 0.344 0.656
I44.0 Atrioventricular block, first degree
0.000 0.346 0.654
E07.1 Dyshormogenetic goitre
0.000 0.348 0.652
E07.0 Hypersecretion of calcitonin
0.000 0.348 0.652
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.348 0.652
E05.5 Thyroid crisis or storm
0.000 0.349 0.651
E05.4 Thyrotoxicosis factitia
0.000 0.349 0.651
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.349 0.651
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.349 0.651
I31.8 Other specified diseases of pericardium
0.000 0.349 0.651
I31.2 Haemopericardium, not elsewhere classified
0.000 0.349 0.651
I31.0 Chronic adhesive pericarditis
0.000 0.349 0.651
G83.4 Cauda equina syndrome
0.651 0.349 0.000
I36 Nonrheumatic tricuspid valve disorders
0.000 0.350 0.650
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.350 0.650
K75.0 Abscess of liver
0.000 0.351 0.649
M77 Other enthesopathies
0.000 0.353 0.647
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.353 0.647
I15.8 Other secondary hypertension
0.000 0.355 0.645
I15.2 Hypertension secondary to endocrine disorders
0.000 0.355 0.645
I15.0 Renovascular hypertension
0.000 0.355 0.645
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.355 0.645
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.356 0.644
E89.3 Postprocedural hypopituitarism
0.000 0.356 0.644
E46 Unspecified protein-energy malnutrition
0.000 0.356 0.644
K82.0 Obstruction of gallbladder
0.000 0.358 0.642
M12 Other specific arthropathies
0.000 0.358 0.641
K73.2 Chronic active hepatitis, not elsewhere classified
0.000 0.359 0.641
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.359 0.641
H42 Glaucoma in diseases classified elsewhere
0.000 0.359 0.641
J86.0 Pyothorax with fistula
0.000 0.360 0.640
E13.8 With unspecified complications
0.000 0.361 0.639
E13.7 With multiple complications
0.000 0.361 0.639
E13.6 With other specified complications
0.000 0.361 0.639
E13.5 With peripheral circulatory complications
0.000 0.361 0.639
E13.4 With neurological complications
0.000 0.361 0.639
E13.3 With ophthalmic complications
0.000 0.361 0.639
E13.2 With renal complications
0.000 0.361 0.639
E13.1 With ketoacidosis
0.000 0.361 0.639
E13.0 With coma
0.000 0.361 0.639
I22.8 Subsequent myocardial infarction of other sites
0.000 0.362 0.638
H66 Suppurative and unspecified otitis media
0.000 0.363 0.637
M07.38 Other psoriatic arthropathies (Other)
0.000 0.364 0.635
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.364 0.635
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.364 0.635
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.364 0.635
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.364 0.635
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.364 0.635
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.364 0.635
M65.44 Radial styloid tenosynovitis [de Quervain] (Hand)
0.000 0.365 0.635
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.365 0.634
K90.8 Other intestinal malabsorption
0.000 0.365 0.634
K72.1 Chronic hepatic failure
0.000 0.366 0.634
Q50-Q56 Congenital malformations of genital organs
0.000 0.366 0.634
J45.8 Mixed asthma
0.000 0.367 0.633
J45.1 Nonallergic asthma
0.000 0.367 0.633
E89.2 Postprocedural hypoparathyroidism
0.000 0.367 0.633
M75.2 Bicipital tendinitis
0.000 0.371 0.629
I24.1 Dressler's syndrome
0.000 0.371 0.629
M65.9 Synovitis and tenosynovitis, unspecified
0.000 0.374 0.626
H66.3 Other chronic suppurative otitis media
0.000 0.374 0.626
M65.43 Radial styloid tenosynovitis [de Quervain] (Forearm)
0.000 0.379 0.621
M00-M03 Infectious arthropathies
0.000 0.380 0.620
K60.4 Rectal fistula
0.000 0.382 0.618
I37 Pulmonary valve disorders
0.000 0.382 0.617
I51.0 Cardiac septal defect, acquired
0.000 0.384 0.616
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.385 0.614
J85 Abscess of lung and mediastinum
0.000 0.385 0.615
J98.0 Diseases of bronchus, not elsewhere classified
0.000 0.386 0.614
J41 Simple and mucopurulent chronic bronchitis
0.000 0.386 0.614
M77.1 Lateral epicondylitis
0.000 0.390 0.610
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.391 0.609
M06.38 Rheumatoid nodule (Other)
0.000 0.391 0.609
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.391 0.609
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.391 0.609
M06.33 Rheumatoid nodule (Forearm)
0.000 0.391 0.609
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.391 0.609
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.391 0.609
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.391 0.609
M70 Soft tissue disorders related to use, overuse and pressure
0.000 0.391 0.609
E83.9 Disorder of mineral metabolism, unspecified
0.566 0.392 0.043
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.392 0.608
H53-H54 Visual disturbances and blindness
0.000 0.394 0.606
K50.1 Crohn's disease of large intestine
0.000 0.396 0.604
I46.1 Sudden cardiac death, so described
0.000 0.396 0.604
J95 Postprocedural respiratory disorders, not elsewhere classified
0.000 0.396 0.604
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.397 0.603
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.397 0.603
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.397 0.603
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.397 0.603
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.397 0.603
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.397 0.603
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.397 0.603
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.397 0.603
H60 Otitis externa
0.000 0.398 0.602
M88 Paget's disease of bone [osteitis deformans]
0.000 0.398 0.602
J98.4 Other disorders of lung
0.000 0.399 0.601
M10 Gout
0.000 0.399 0.600
K52.1 Toxic gastro-enteritis and colitis
0.001 0.400 0.599
E73 Lactose intolerance
0.000 0.404 0.596
Q61.3 Polycystic kidney, unspecified
0.000 0.406 0.594
G83.1 Monoplegia of lower limb
0.592 0.407 0.000
H61 Other disorders of external ear
0.000 0.409 0.591
H35 Other retinal disorders
0.000 0.410 0.590
I31.1 Chronic constrictive pericarditis
0.000 0.410 0.590
K52.9 Non-infective gastro-enteritis and colitis, unspecified
0.000 0.410 0.590
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.000 0.411 0.589
I23.8 Other current complications following acute myocardial infarction
0.000 0.412 0.588
Q61.0 Congenital single renal cyst
0.000 0.412 0.587
H40.6 Glaucoma secondary to drugs
0.000 0.413 0.587
H40.4 Glaucoma secondary to eye inflammation
0.000 0.413 0.587
H40.3 Glaucoma secondary to eye trauma
0.000 0.413 0.587
K60.1 Chronic anal fissure
0.000 0.413 0.587
K73.8 Other chronic hepatitis, not elsewhere classified
0.000 0.413 0.587

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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